retinoic acid receptors

Summary

Summary: Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.

Top Publications

  1. ncbi The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
  2. ncbi Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:639-46. 2007
  3. ncbi Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
    A J Hörlein
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 377:397-404. 1995
  4. ncbi An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
  5. pmc T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:29-39. 2008
  6. ncbi Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
    Masayuki Tsuji
    Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Immunity 29:261-71. 2008
  7. ncbi Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:942-9. 2007
  8. ncbi Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    Roza Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 448:480-3. 2007
  9. ncbi The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
    Anne Brüstle
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, 35043 Marburg, Germany
    Nat Immunol 8:958-66. 2007
  10. ncbi International Union of Pharmacology. LX. Retinoic acid receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:712-25. 2006

Detail Information

Publications352 found, 100 shown here

  1. ncbi The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
    ..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases...
  2. ncbi Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:639-46. 2007
    ..Our results demonstrate that human T(H)-17 cells have distinct migratory capacity and antigenic specificities and establish a link between microbial products, T helper cell differentiation and homing in response to fungal antigens...
  3. ncbi Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
    A J Hörlein
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 377:397-404. 1995
    ....
  4. ncbi An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
    ..This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues...
  5. pmc T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:29-39. 2008
    ..Therefore, Th17 differentiation is directed by two lineage-specific nuclear receptors, ROR alpha and ROR gamma...
  6. ncbi Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
    Masayuki Tsuji
    Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Immunity 29:261-71. 2008
    ..These findings provide insight into the crosstalk between bacteria, ROR gamma t(+)LTi cells, SCs, DCs, and B cells required for ILF formation and establish a critical role of ILFs in T cell-independent IgA synthesis in gut...
  7. ncbi Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:942-9. 2007
    ....
  8. ncbi Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    Roza Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 448:480-3. 2007
    ..IL-21 is therefore an autocrine cytokine that is sufficient and necessary for T(H)17 differentiation, and serves as a target for treating inflammatory diseases...
  9. ncbi The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
    Anne Brüstle
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, 35043 Marburg, Germany
    Nat Immunol 8:958-66. 2007
    ..Our data position IRF4 at the center of T helper cell development, influencing not only T helper type 2 but also T(H)-17 differentiation...
  10. ncbi International Union of Pharmacology. LX. Retinoic acid receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:712-25. 2006
    Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARalpha, RARbeta, and RARgamma), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid is all-trans-retinoic acid...
  11. ncbi Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
    H Chen
    Howard Hughes Medical Institute, School of Medicine, University of California at San Diego, La Jolla 92037, USA
    Cell 90:569-80. 1997
    ....
  12. pmc Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells
    Jonathan A Hill
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Immunity 29:758-70. 2008
    ..Thus, cytokine-producing CD44(hi) cells actively restrain TGF-beta-mediated Foxp3 expression in naive T cells, and this balance can be shifted or fine-tuned by RA...
  13. ncbi A decade of molecular biology of retinoic acid receptors
    P Chambon
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERUM ULP, College de France, Strasbourg, France
    FASEB J 10:940-54. 1996
    ..This review focuses on recent developments, particularly in the area of structure-function relationships...
  14. ncbi Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants
    C Mendelsohn
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    Development 120:2749-71. 1994
    ..We discuss several possibilities that may account for the apparent functional redundancy observed amongst retinoic acid receptors during embryogenesis.
  15. ncbi Role of the histone deacetylase complex in acute promyelocytic leukaemia
    R J Lin
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 391:811-4. 1998
    Non-liganded retinoic acid receptors (RARs) repress transcription of target genes by recruiting the histone deacetylase complex through a class of silencing mediators termed SMRT or N-CoR...
  16. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
    ..Therefore, the decision of antigen-stimulated cells to differentiate into either T(H)17 or T(reg) cells depends on the cytokine-regulated balance of RORgammat and Foxp3...
  17. pmc Cell-specific interaction of retinoic acid receptors with target genes in mouse embryonic fibroblasts and embryonic stem cells
    Laurence Delacroix
    Immunologie et Maladies Infectieuses, GIGA 2, Bat B34, 1 ave de l Hôpital, 4000 Liege, Belgium
    Mol Cell Biol 30:231-44. 2010
    ....
  18. pmc Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis
    S Kurebayashi
    Cell Biology Section, Laboratory of Pulmonary Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 97:10132-7. 2000
    ..Our observations indicate that RORgamma is essential for lymphoid organogenesis and plays an important regulatory role in thymopoiesis. Our findings support a model in which RORgamma negatively controls apoptosis in thymocytes...
  19. ncbi Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Science 305:248-51. 2004
    ..Our results suggest that intestinal RORgammat+ cells are local organizers of mucosal lymphoid tissue...
  20. ncbi IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
    ..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
  21. ncbi 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor
    R A Heyman
    Ligand Pharmaceuticals, Inc, San Diego, California 92121
    Cell 68:397-406. 1992
    ..The discovery of this novel hormone points to the key role retinoid metabolism may have in generating new signaling pathways...
  22. ncbi PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator
    Rushad Pavri
    Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, New Jersey 08854, USA
    Mol Cell 18:83-96. 2005
    ..PARP-1 appears to function as a specificity factor regulating the RA-induced switch of Mediator from the inactive (Cdk8+) to the active (Cdk8-) state in RAR-dependent transcription...
  23. ncbi The role of retinoids and retinoic acid receptors in normal hematopoiesis
    S J Collins
    Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Leukemia 16:1896-905. 2002
    ..acute promyelocytic leukemia (APL) has led to numerous studies assessing the role of retinoids and the retinoic acid receptors (RARs) in the regulation of normal hematopoiesis...
  24. ncbi Retinoids in cancer therapy and chemoprevention: promise meets resistance
    Sarah J Freemantle
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    Oncogene 22:7305-15. 2003
    ..In this regard, the retinoids are useful pharmacological tools to reveal important pathways targeted in cancer therapy and chemoprevention...
  25. pmc Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation
    Marie Laure Michel
    Faculte de Medecine, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8147, Hopital Necker, Universite Paris Descartes, 161 rue de Sevres, 75743, Paris, Cedex 15, France
    Proc Natl Acad Sci U S A 105:19845-50. 2008
    ..In conclusion, our findings demonstrate an alternative thymic pathway leading to the development of iNKT17 cells that requires ROR-gammat expression...
  26. ncbi Molecular changes associated with oral dysplasia progression and acquisition of immortality: potential for its reversal by 5-azacytidine
    Fiona McGregor
    The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Glasgow G61 1BD, Scotland
    Cancer Res 62:4757-66. 2002
    ..The possibility of reversing the immortal phenotype of some dysplasias by Aza-C may be of clinical usefulness...
  27. ncbi Vitamin A deficiency and relational memory deficit in adult mice: relationships with changes in brain retinoid signalling
    Nicole Etchamendy
    CNRS UMR 5106, Lab Neurosciences Cognitives, Universite de Bordeaux 1, Avenue des Facultes, 33405 Talence Cedex, France
    Behav Brain Res 145:37-49. 2003
    ..Acting via transcription factors, retinoids can regulate gene expression via their nuclear receptors [retinoic acid receptors (RARs) and retinoid X receptors (RXRs)]...
  28. pmc Impaired retinoic acid (RA) signal leads to RARbeta2 epigenetic silencing and RA resistance
    Mingqiang Ren
    Roswell Park Cancer Institute, Elm and Carlton Streets, C and V Bldg, Rm 226, Buffalo, NY 14263
    Mol Cell Biol 25:10591-603. 2005
    ..This report provides proof of principle that RARbeta2 silencing and RA resistance are consequent to an impaired integration of RA signal at RARbeta2 chromatin...
  29. ncbi Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer
    Silvia M Sirchia
    Laboratory of Genetics and Biochemistry, San Paolo University Hospital, School of Medicine, University of Milan, 20142 Milan, Italy
    Cancer Res 62:2455-61. 2002
    ..This study may have translational implications for breast cancer and other cancers carrying an epigenetically silenced RARbeta P2 promoter...
  30. ncbi Retinoic acid receptors and tissue-transglutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells
    S Joshi
    Department of Internal Medicine, Cardiovascular Research Institute, The Texas A and M University System Health Science Center, Temple, TX 76504, USA
    Oncogene 25:240-7. 2006
    ..In addition to the long-term effects of RA that are coupled with cell differentiation, short-term effects involve migration and invasion of neuroblastoma SH-SY5Y cells...
  31. ncbi A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins
    S Zhong
    Department of Human Genetics, Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, New York, USA
    Nat Genet 23:287-95. 1999
    ..Our data define a new pathway for the control of cell growth and tumorigenesis, and provide a new model for the pathogenesis of acute promyelocytic leukaemia (APL)...
  32. ncbi GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis
    Ryoji Fujiki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Nature 459:455-9. 2009
    ..Thus, nuclear MLL5 GlcNAcylation triggers cell lineage determination of HL60 through activation of its HKMT activity...
  33. pmc Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity
    D L Misner
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, Howard Hughes Medical Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:11714-9. 2001
    ..These data suggest a major mental consequence for the hundreds of millions of adults and children who are vitamin A deficient...
  34. pmc Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid
    P Leroy
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Unite 184 de Biologie Moleculaire et de Genie Genetique de l INSERM, Faculte de Medecine, Strasbourg, France
    EMBO J 10:59-69. 1991
    ....
  35. pmc The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat
    Nicolas Manel
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 9:641-9. 2008
    ..Our studies identify RORgammat as having a central function in the differentiation of human T(H)-17 cells from naive CD4+ T cells and suggest that similar cytokine pathways are involved in this process in mice and humans...
  36. ncbi How acute promyelocytic leukaemia revived arsenic
    Jun Zhu
    CNRS UPR 9051, Laboratoire associé du comité de Paris de la ligue contre le cancer, affilié à l Université de Paris VII, Hopital St Louis, 1 avenue C Vellefaux, 75475 Paris Cedex 10, France
    Nat Rev Cancer 2:705-13. 2002
    ....
  37. ncbi Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism
    F Muscatelli
    ICRF Laboratories, John Radcliffe Hospital, Oxford, UK
    Nature 372:672-6. 1994
    ..But in four sporadic cases and a single familial case, no point mutations were found, suggesting genetic heterogeneity or differential expression of DAX-1...
  38. ncbi Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
    Carmelo Luci
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, 13288 Marseille, France
    Nat Immunol 10:75-82. 2009
    ..Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair...
  39. ncbi Diverse actions of retinoid receptors in cancer prevention and treatment
    Nigel P Mongan
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021, USA
    Differentiation 75:853-70. 2007
    ..The physiological actions of retinoids are mediated primarily by the retinoic acid receptors alpha, beta, and gamma (RARs) and rexinoid receptors alpha, beta, and gamma...
  40. ncbi Role of retinoid signalling in the adult brain
    Michelle A Lane
    Department of Human Ecology, Division of Nutritional Sciences, The University of Texas at Austin, Austin, TX 78712, USA
    Prog Neurobiol 75:275-93. 2005
    ..Overall, the data underscore the likely importance of adequate nutritional Vitamin A status for adult brain function and highlight retinoid signalling pathways as potential novel therapeutic targets for neurological diseases...
  41. ncbi RORA, a large common fragile site gene, is involved in cellular stress response
    Y Zhu
    Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, MI, USA
    Oncogene 25:2901-8. 2006
    ....
  42. pmc Opposing effects of retinoic acid on cell growth result from alternate activation of two different nuclear receptors
    Thaddeus T Schug
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA
    Cell 129:723-33. 2007
    ..Opposing effects of RA on cell growth thus emanate from alternate activation of two different nuclear receptors...
  43. ncbi The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York 10016, USA
    Immunol Rev 195:81-90. 2003
    ..We propose that RORgammat, together with the inhibitor of basic helix-loop-helix transcription factor Id2, ensures generation and survival of fetal LTi cells necessary for the development of LNs and PPs...
  44. ncbi Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors
    V Giguere
    Division of Endocrinology, Hospital for Sick Children, Toronto, Ontario, Canada
    Genes Dev 8:538-53. 1994
    Three isoforms of a novel member of the steroid hormone nuclear receptor superfamily related to the retinoic acid receptors have been identified...
  45. ncbi A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase
    Michael T Sturniolo
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Biol Chem 278:48066-73. 2003
    ..Our studies suggest that TIG3 facilitates the terminal stages in keratinocyte differentiation via activation of type I transglutaminase...
  46. pmc Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells
    Yongpeng Gu
    Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA
    Eur J Immunol 38:1807-13. 2008
    ..These data demonstrate that Th17 cytokines and RORgammat are also expressed in macrophages and that IL-10 negatively regulates the expression of Th17 cytokines and RORgammat by both macrophages and T cells...
  47. ncbi Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH
    R A Schneider
    Department of Orthopaedic Surgery, 533 Parnassus Avenue, Suite U-453, University of California at San Francisco, San Francisco, CA 94143-0514, USA
    Development 128:2755-67. 2001
    ..We propose that the local source of retinoic acid in the rostral head initiates a regulatory cascade that coordinates forebrain and frontonasal process morphogenesis...
  48. ncbi Aberrant methylation during cervical carcinogenesis
    A K Virmani
    Hamon Center for Therapeutic Oncology Research, and Department of Pathology, University of Texas Southwestern Medical Center, Dallas 85930, USA
    Clin Cancer Res 7:584-9. 2001
    ....
  49. ncbi Unique response pathways are established by allosteric interactions among nuclear hormone receptors
    B M Forman
    Salk Institute for Biological Studies, San Diego, California, USA
    Cell 81:541-50. 1995
    ..These findings suggest that allosteric interactions among heterodimers create complexes with unique properties. We suggest that allostery is a critical feature underlying the generation of diversity in hormone response networks...
  50. ncbi Mechanism of fenretinide (4-HPR)-induced cell death
    J M Wu
    Department of Biochemistry and Molecular Biology, New York Medical College, NY 10595, USA
    Apoptosis 6:377-88. 2001
    ..Fenretinide also induces apoptosis by elevating reactive oxygen species (ROS), unrelated to changes in ceramide-caspases. Thus multiple, distinct pathways contribute to the induction of apoptosis by fenretinide...
  51. pmc Function of retinoic acid receptors during embryonic development
    Manuel Mark
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Département de Biologie Cellulaire and Développement, Strasbourg, France
    Nucl Recept Signal 7:e002. 2009
    ..Spatio-temporally-controlled somatic mutations generated in given cell types/tissues and at chosen times during postnatal life, will be required to reveal all the functions of RAR and RXR throughout the lifetime of the mouse...
  52. ncbi Nuclear receptors and lipid physiology: opening the X-files
    A Chawla
    Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, Post Office Box 85800, San Diego, CA 92186 5800, USA
    Science 294:1866-70. 2001
    ....
  53. ncbi The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
    Nicolas Preitner
    Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 4, Geneva, Switzerland
    Cell 110:251-60. 2002
    ..While REV-ERBalpha influences the period length and affects the phase-shifting properties of the clock, it is not required for circadian rhythm generation...
  54. pmc Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity
    Jason Aoto
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720 3200, USA
    Neuron 60:308-20. 2008
    ..Together, our data suggest that RA functions in homeostatic plasticity as a signaling molecule that increases synaptic strength by a protein synthesis-dependent mechanism...
  55. pmc Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity
    Bita Maghsoodi
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Proc Natl Acad Sci U S A 105:16015-20. 2008
    ..Taken together, our results provide a direct link between dendritically localized RARalpha and local GluR1 synthesis in RNA granules during RA-mediated synaptic signaling in homeostatic synaptic plasticity...
  56. ncbi A transcriptional co-repressor that interacts with nuclear hormone receptors
    J D Chen
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 377:454-7. 1995
    ..Together, our results identify a new class of cofactors which may be important mediators of hormone action...
  57. pmc 5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
    Andreas Schmidt
    Division of Clinical Pharmacology, Department of Medicine, Ludwig Maximilian University Munich, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 106:12067-72. 2009
    ..Together, our findings accurately define a minimal molecular pattern sufficient to activate RIG-I that can be found in viral genomes or transcripts...
  58. ncbi Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons
    A Cimini
    Department of Basic and Applied Biology, University of L Aquila, via Vetoio n 10, 67010 Coppito AQ, Italy
    Neuroscience 130:325-37. 2005
    ..In particular, we point toward the PPARbeta/delta isotype as a key factor in neuronal differentiation...
  59. ncbi Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2/neu antagonist in breast cancer cells. Evidence for a role in apoptosis
    Olubunmi Afonja
    Department of Pediatrics, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Oncogene 23:8135-45. 2004
    ..b>Retinoic acid receptors (RARs), members of the steroid/thyroid hormone receptor gene family, are ligand-dependent transcription ..
  60. ncbi Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis
    Manuel Mark
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut Clinique de la Souris, Centre National de la Recherche Scientifique INSERM, Universite Louis Pasteur de Strasbourg, College de France, 67404 Illkirch Cedex, CU de Strasbourg, France
    Annu Rev Pharmacol Toxicol 46:451-80. 2006
    ..Additional cell type-restricted and temporally controlled somatic mutagenesis is required to determine the functions of RARs and RXRs during postnatal life...
  61. ncbi The RXR heterodimers and orphan receptors
    D J Mangelsdorf
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050, USA
    Cell 83:841-50. 1995
  62. ncbi Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia
    S Thameem Dheen
    Department of Anatomy, Molecular Neurobiology Laboratory, Faculty of Medicine, National University of Singapore, Singapore
    Glia 50:21-31. 2005
    ..These results suggest that RA may inhibit the neurotoxic effect of activated microglia by suppressing the production of inflammatory cytokines and cytotoxic molecules...
  63. ncbi Characterization of three RXR genes that mediate the action of 9-cis retinoic acid
    D J Mangelsdorf
    Salk Institute for Biological Studies, La Jolla, California
    Genes Dev 6:329-44. 1992
    ..This study suggests that the RXR family plays critical roles in diverse aspects of development, from embryo implantation to organogenesis and central nervous system differentiation, as well as in adult physiology...
  64. ncbi Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin
    Frank Tippmann
    Institute of Biochemistry, University of Mainz, Becherweg 30, D 55099 Mainz, Germany
    FASEB J 23:1643-54. 2009
    ..The results of this study may have clinical relevance because acitretin has been approved for the treatment of psoriasis since 1997 and found generally safe for long-term use in humans...
  65. ncbi Promoter hypermethylation profile of ovarian epithelial neoplasms
    Prakash B Makarla
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Clin Cancer Res 11:5365-9. 2005
    ..The aim of this study was to compare the promoter hypermethylation profiles of ovarian epithelial neoplasms to better understand the role of epigenetic silencing in carcinogenesis...
  66. ncbi Role of CBP/P300 in nuclear receptor signalling
    D Chakravarti
    The Gene Expression Laboratory, The Howard Hughes Medical Institute, La Jolla, California 92037, USA
    Nature 383:99-103. 1996
    ....
  67. ncbi Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
    T P Yao
    Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 93:361-72. 1998
    ..Our results provide genetic evidence that a coactivator endowed with histone acetyltransferase activity is essential for mammalian cell proliferation and development...
  68. ncbi Rapid, nongenomic actions of retinoic acid on phosphatidylinositol-3-kinase signaling pathway mediated by the retinoic acid receptor
    Susana Masiá
    Biology of Hormone Action Unit, Department of Molecular and Cellular Pathology and Therapy, Instituto de Biomedicina de Valencia Consejo Superior de Investigaciones Cientificas, E 46010 Valencia, Spain
    Mol Endocrinol 21:2391-402. 2007
    ..Our results support a mechanism in which ligand binding to RAR would play a major role in the assembly and intracellular location of a signaling complex involving RAR and the subunits of PI3K...
  69. ncbi Retinoids: potential in cancer prevention and therapy
    Nicole Clarke
    Department of Cell Biology and Signal Transduction, Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC CNRS INSERM ULP, BP 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Expert Rev Mol Med 6:1-23. 2004
    ..Retinoids act through two types of receptors - retinoic acid receptors (RAR alpha, RAR beta and RAR gamma) and retinoid X receptors (RXR alpha, RXR beta and RXR gamma) - which ..
  70. pmc Disruption of retinoid-related orphan receptor beta changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice
    E Andre
    Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development S A, 14, Chemin des Aulx, CH 1228 Plan les Ouates, Switzerland
    EMBO J 17:3867-77. 1998
    ..The overall behavioral phenotype of RORbeta-/- mice, together with the chromosomal localization of the RORbeta gene, suggests a close relationship to the spontaneous mouse mutation vacillans described >40 years ago...
  71. ncbi Retinoic acid receptor-beta: an endogenous inhibitor of the perinatal formation of pulmonary alveoli
    G D Massaro
    Lung Biology Laboratory, Department of Pediatrics, Georgetown University School of Medicine, Washington District of Columbia 20007 2197, USA
    Physiol Genomics 4:51-7. 2000
    ..Suppressing perinatal RARbeta signaling by RARbeta antagonists may offer a novel, nonsurgical, means of preventing, or remediating, failed septation in prematurely born children...
  72. ncbi Hypermethylation of the retinoic acid receptor-beta(2) gene in head and neck carcinogenesis
    Emile M Youssef
    Departments of Thoracic Head and Neck Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77345, USA
    Clin Cancer Res 10:1733-42. 2004
    ..This study was conducted to determine whether RAR-beta(2) gene expression in such lesions can be silenced by promoter methylation...
  73. ncbi An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression
    M Y Chiang
    Gene Expression Laboratory, The Salk Institute for Biological Studies, Howard Hughes Medical Institute, La Jolla, California 92037, USA
    Neuron 21:1353-61. 1998
    ..These findings not only genetically uncouple LTP and LTD but also reveal a novel and unexpected role for vitamin A in higher cognitive functions...
  74. pmc All-trans retinoic acid induces COX-2 and prostaglandin E2 synthesis in SH-SY5Y human neuroblastoma cells: involvement of retinoic acid receptors and extracellular-regulated kinase 1/2
    Matilde Alique
    Facultad de Medicina, Departamento de Fisiologia, Campus Universitario, Universidad de Alcala, Madrid, Spain
    J Neuroinflammation 4:1. 2007
    ..This effect was mediated by retinoic acid receptors (RARs) and was associated with increased COX-2 expression in the spinal cord...
  75. pmc Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis
    Felix A Mic
    OncoDevelopmental Biology Program, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:7135-40. 2003
    ..Because 9-cis-RA is undetectable and unnecessary for Raldh2-/- rescue, and others have shown that 4-oxo-RA is unnecessary for mouse development, all-trans-RA emerges as the only ligand clearly necessary for retinoid receptor signaling...
  76. ncbi Involvement of all-trans-retinoic acid in the breakdown of retinoic acid receptors alpha and gamma through proteasomes in MCF-7 human breast cancer cells
    T Tanaka
    National Cancer Institute, National Institutes of Health, Building 37, Room 3A-17, 37 Convent Drive, Bethesda, MD 20892-4255, USA
    Biochem Pharmacol 61:1347-55. 2001
    ..These data suggest that RA induces the breakdown of RARs through a process involving ubiquitination and that this phenomenon causes a reduction in the formation of DNA-receptor complexes...
  77. ncbi All-trans-retinoic acid stimulates translation and induces spine formation in hippocampal neurons through a membrane-associated RARalpha
    Na Chen
    Nutritional Science and Toxicology, University of California, Berkeley, California 94720, USA
    FASEB J 22:236-45. 2008
    ..These data provide mechanistic insight into atRA function in the hippocampus and identify a unique membrane-associated RARalpha that mediates rapid induction of neuronal translation by atRA...
  78. pmc CSK controls retinoic acid receptor (RAR) signaling: a RAR-c-SRC signaling axis is required for neuritogenic differentiation
    Nandini Dey
    Section of Pediatric Hematology Oncology, Department of Pediatrics, AFLAC Cancer Center and Blood Disorders Services, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA 30022, USA
    Mol Cell Biol 27:4179-97. 2007
    ..We have elucidated a nongenomic extranuclear signal mediated by the RAR-SRC interaction that is negatively regulated by CSK and is required for RA-induced neuronal differentiation...
  79. pmc Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells
    Robert F Gillespie
    Molecular Biology Program of Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA
    J Mol Biol 372:298-316. 2007
    ..These studies provide insight into the dynamics of association of co-regulators with RAREs and demonstrate a novel link between RA signaling and PcG repression...
  80. pmc Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily
    U Dressel
    Genetisches Institut der Justus Liebig Universitat, D 35392 Giessen, Germany
    Mol Cell Biol 19:3383-94. 1999
    ..These properties, taken together, show that Alien has the characteristics of a corepressor. Thus, Alien represents a member of a novel class of corepressors specific for selected members of the nuclear hormone receptor superfamily...
  81. ncbi Requirement for RORgamma in thymocyte survival and lymphoid organ development
    Z Sun
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
    Science 288:2369-73. 2000
    ..Hence, RORgamma has critical functions in T cell repertoire selection and lymphoid organogenesis...
  82. pmc MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
    Hye Kyung Lee
    Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Seoul, Korea
    EMBO J 26:3545-57. 2007
    ..Our data suggest that MED25, in cooperation with CBP and Mediators through its distinct domains, imposes a selective advantage on RAR/RXR activation...
  83. pmc RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells
    Y W He
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    Immunity 9:797-806. 1998
    ..We propose that the role of RORgamma t expression in immature thymocytes is to inhibit Fas ligand expression and cytokine secretion following engagement of their TCR during positive or negative selection...
  84. ncbi Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway
    Charles B Stephensen
    U S Department of Agriculture Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA 95616, USA
    J Immunol 168:4495-503. 2002
    ..These data show that stimulation of the RXR pathway enhances Th2 development, perhaps by affecting the relative expression of pertinent transcription factors, cytokines, and cytokine receptors...
  85. pmc Down-regulation of retinoic acid receptor alpha signaling is required for sacculation and type I cell formation in the developing lung
    Cherry Wongtrakool
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA
    J Biol Chem 278:46911-8. 2003
    ..Down-regulation of RA signaling, however, is required to allow completion of later steps of this differentiation program that ultimately form mature type I and II cells...
  86. ncbi Transcriptional activators stimulate DNA repair
    Philippe Frit
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, B P 163, 67404 Cedex, Illkirch, France
    Mol Cell 10:1391-401. 2002
    ....
  87. ncbi Retinoic acid receptor beta 2 (RAR beta 2) null mutant mice appear normal
    C Mendelsohn
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Institut de Chimie Biologique, Faculte de Medecine, Strasbourg, France
    Dev Biol 166:246-58. 1994
    ..By challenging RAR beta 2 null embryos with teratogenic doses of RA, we have also directly addressed the question of whether RAR beta 2 is required for mediating RA-induced malformations...
  88. ncbi Retinoic acid stimulates the cell cycle machinery in normal T cells: involvement of retinoic acid receptor-mediated IL-2 secretion
    Aase Ertesvag
    Department of Medical Biochemistry, Institute Group of Basic Medical Sciences, Faculty of Medicine, University of Oslo, N 0317 Oslo, Norway
    J Immunol 169:5555-63. 2002
    ..Taken together, these results suggest that atRA stimulates the cell cycle machinery and proliferation of normal human T cells by increasing IL-2 secretion through mechanisms involving RARs...
  89. ncbi Distinct promoter hypermethylation of p16INK4a, CDH1, and RAR-beta in intestinal, diffuse-adherent, and diffuse-scattered type gastric carcinomas
    Naohide Oue
    Department of Molecular Pathology, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    J Pathol 198:55-9. 2002
    ....
  90. ncbi Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells
    E Sonneveld
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
    Cell Growth Differ 9:629-37. 1998
    ..This substrate specificity is promising for finding retinoids that are not recognized by this enzyme and, therefore, could be more effective in growth inhibition of susceptible cancer cells...
  91. ncbi Transcriptional regulation in acute promyelocytic leukemia
    R J Lin
    Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California, CA 92037, USA
    Oncogene 20:7204-15. 2001
    ..These studies have been instrumental in our understanding of the process of leukemogenesis in general and have laid the scientific foundation for the novel concept of transcription therapy in the treatment of human cancer...
  92. pmc Antagonists of retinoic acid receptors (RARs) are potent growth inhibitors of prostate carcinoma cells
    L A Hammond
    Division of Cancer Studies, University of Birmingham Medical School, Edgbaston, Birmingham, B15 2TT, UK
    Br J Cancer 85:453-62. 2001
    Novel synthetic antagonists of retinoic acid receptors (RARs) have been developed...
  93. ncbi The theory of APL
    F Piazza
    Molecular Biology Program, Department of Pathology, Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, 1275 York Avenue, New York, New York, NY 10021, USA
    Oncogene 20:7216-22. 2001
    ..Here we will review the relevant conclusions and the open questions that stem from a decade of in vivo analysis of APL pathogenesis in the mouse in transgenic and knock-out models...
  94. ncbi Identification of a second human retinoic acid receptor
    N Brand
    Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS, Faculte de Medecine, Strasbourg, France
    Nature 332:850-3. 1988
    ..This demonstrates the existence of two human retinoic acid receptors designated RAR-alpha and RAR-beta.
  95. ncbi Dominant-negative retinoic acid receptors elicit epidermal defects through a non-canonical pathway
    Chang Feng Chen
    Division of Experimental Medicine, Department of Medicine, McGill University, Montreal K1H 8M5, Canada
    J Biol Chem 280:3012-21. 2005
    ..These findings suggest that dnRARs may impact on epidermal development through one or more non-canonical pathways, which are independent of receptor-DNA interaction...
  96. ncbi Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer
    M Widschwendter
    Department of Obstetrics and Gynecology, University of Innsbruck, Austria
    J Natl Cancer Inst 92:826-32. 2000
    ..RAR-beta2 expression is reduced in many malignant tumors, and we examined whether methylation of RAR-beta2 could be responsible for this silencing...
  97. ncbi Promoter of FGF8 reveals a unique regulation by unliganded RARalpha
    Vincent Brondani
    Oncology Research, Novartis Pharma AG, CH 4002 Basel, Switzerland
    J Mol Biol 319:715-28. 2002
    ....
  98. ncbi Positive and negative regulation of granulopoiesis by endogenous RARalpha
    P Kastner
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Blood 97:1314-20. 2001
    ..Thus, the block in granulopoiesis exerted by RARalpha fusion proteins expressed in APL cells may correspond to an amplification of a normal function of unliganded RARalpha...
  99. pmc Activation of retinoic acid receptors by dihydroretinoids
    Alexander R Moise
    Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
    Mol Pharmacol 76:1228-37. 2009
    ..we found that dihydroretinoids have a narrow transcriptional profile limited primarily to activation of retinoic acid receptors (RARs)...
  100. pmc Transcriptional regulation of Th17 cell differentiation
    Ivaylo I Ivanov
    The Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine and New York, NY 10016, United States
    Semin Immunol 19:409-17. 2007
    ..Here we review how the nuclear orphan receptor RORgammat functions to coordinate the diverse cytokine-induced signals and thus controls Th17 cell differentiation...
  101. ncbi MNU-induced carcinogenesis of rat mammary gland: effect of thyroid hormone on expression of retinoic acid receptors in tumours of mammary gland
    Dana Macejova
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovak Republic
    Mol Cell Endocrinol 244:47-56. 2005
    ..A different pattern of expression of retinoid or rexinoid receptors was found either in MNU-induced mammary carcinomas in both hypothyroid and hyperthyroid rats...

Research Grants64

  1. Retinoid Mediated Protection Against Reactive Oxygen Species Induced Cytotoxicity
    Serrine S Lau; Fiscal Year: 2013
    ..this therapeutic dose, aTRA induces Nrf2-responsive antioxidant HO-1 and NQO1 genes, as well as nuclear retinoic acid receptors RAR?, RAR?2, RAR?2, and retinoid X receptors RXR? in the kidney...
  2. ANALYSIS OF NEMATODE SEX DETERMINATION
    Barbara J Meyer; Fiscal Year: 2013
    ..Our protein complexes give us insight into the mechanisms underlying the genome rearrangements associated with such a cancerous state. ..
  3. Targeted epigenetic therapy of triple-negative breast cancer
    Samuel Waxman; Fiscal Year: 2013
    ..phenotype involves epigenetic reprogramming contributing to re-expression of Ecadherin, estrogen and retinoic acid receptors (ER and RARs) adds support to the hypothesis of reversion of the Epithelial/Mesenchymal Transition (EMT)...
  4. Investigating the Mechanisms Regulating RORgamma Activity
    LAURA ANN SOLT; Fiscal Year: 2013
    ....
  5. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2013
    ..2) We plan to define the domains of the specific retinoic acid receptors (RARs) 1, 2, and 3 (i.e...
  6. Development of sd-rxRNAs as Therapy for Retinoblastoma and Other Malignancies
    Pamela Pavco; Fiscal Year: 2012
    ..The focus of this grant application is to evaluate the applicability of d-rxRNA to silence genes in a retinoblastoma model in vivo. ..
  7. Inhibition in the progression of preinvasive lung cancer by pomegranate.
    Naghma Khan; Fiscal Year: 2012
    ....
  8. Vitamin D: a link to racial disparities in birth outcomes
    Lisa M Bodnar; Fiscal Year: 2012
    ..Improving vitamin D status in pregnant women may be a simple strategy for reducing the excess cases of adverse birth outcomes among black women in the United States. ..
  9. Regulation of Skeletal Growth by Nuclear Retinoid Receptors
    Maurizio Pacifici; Fiscal Year: 2013
    ..The retinoic acid receptors [unreadable], [unreadable] and [unreadable] (RAR[unreadable], RAR[unreadable] and RAR[unreadable]) are ..
  10. Vitamin A dependent events in urinary tract formation.
    Cathy Mendelsohn; Fiscal Year: 2009
    ..Site Congressional Districts: 15th Additional Project/Performance Site Location Organizational Name: DUNS: Street 1: Street 2: City: County: State: Province: Country: Zip/Postal Code: Project/Performance Site Congressional Districts:..
  11. Development of ROR ligands for treatment of metabolic diseases
    Thomas P Burris; Fiscal Year: 2010
    ..RELEVANCE: Our proposed studies to develop ROR targeted drugs may provide the basis for novel therapeutics targeting the RORs for treatment of metabolic disorders such as diabetes, atherosclerosis and obesity. ..
  12. Interplay among NKT cell subsets in alcoholic liver disease
    Vipin Kumar; Fiscal Year: 2013
    ....
  13. Phase I enzymes as part of an epigenetic switch
    Elwood Albert Linney; Fiscal Year: 2013
    ..The "OFF" position would be due to a function of retinoic acid receptors that has not received sufficient notice: in the absenc of retinoic acid, corepressor molecules bind to ..
  14. Retinoid receptor antagonists as novel male contraceptives
    Debra J Wolgemuth; Fiscal Year: 2013
    ..its function at least in part by binding to nuclear receptors of the steroid hormone superfamily, the retinoic acid receptors (RARs)...
  15. Maternal Smoking and the Developing Lung
    Kathleen J Haley; Fiscal Year: 2010
    ..Addressing these questions will provide insight into the role early developmental events have in causing adult lung disease and will suggest novel therapeutic interventions to protect the lung from the effects of maternal smoking. ..
  16. Co-factors in HIV Mucosal Infection
    Gregory A Viglianti; Fiscal Year: 2012
    ..We will test these drugs for their ability to inhibit HIV-1 transmission using purified cells and a unique laboratory-derived tissue model of the female reproductive tract. ..
  17. Postprandial Vitamin A
    WILLIAM BLANER; Fiscal Year: 2009
    ..The 3rd Specific Aim will define the role that retinoic acid signaling, as mediated by retinoic acid receptors (RARs), has in maintaining vitamin A and triglyceride storage/metabolism in liver...
  18. Role of MN1-TEL and MN1 in Leukemogenesis
    Gerard C Grosveld; Fiscal Year: 2010
    ..These studies should also provide leads for the development of novel therapies for AML involving these transcription factors. ..
  19. Signaling pathways and expansion of hematopoietic stem cells in zebrafish
    JILL L DE JONG; Fiscal Year: 2010
    ....
  20. Novel Mucosal Adjuvant for an HIV DNA Vaccine
    Kenneth C Bagley; Fiscal Year: 2010
    ..These adjuvants will be based on a constructs such as a dominant-positive retinoic acid receptor and the enzyme RALDH2 that initiate retinoic acid production. ..
  21. Translational Regulation of Gene Expression in Neonatal PMNs
    Christian Con Yost; Fiscal Year: 2010
    ..Results of these experiments will provide new and important mechanistic insight into the pathogenesis of NEC, and may lead to improvements in the prevention and treatment of this common and often devastating disease of prematurity. ..
  22. FUNCTIONS OF INTRACELLULAR LIPID-BINDING PROTEINS
    Noa Noy; Fiscal Year: 2013
    ..by activating two members of the nuclear receptor family of ligand-activated transcription factors: the retinoic acid receptors (RARs) and the peroxisome proliferator activated receptor?? (PPAR?)...
  23. Hepatic Lipid Mobilization by Nuclear Hormone Receptors
    Yoon Kwang Lee; Fiscal Year: 2013
    ....
  24. Drug Discovery &Synthesis of Contraceptive Agents
    Gunda I Georg; Fiscal Year: 2013
    ..These observations have led to the hypothesis that a selective PDE3A inhibitor could be developed as a female contraceptive agent. ..
  25. Mechanisms of Synovial Joint Formation
    Maurizio Pacifici; Fiscal Year: 2013
    ..that the Wnt/?-catenin pathway does not act alone, but cooperates with the retinoid pathway and nuclear retinoic acid receptors (RARs) to sustain and regulate joint formation...
  26. Mechanism of retinoic acid receptor induced innate immune responses
    Philip T Liu; Fiscal Year: 2011
    ..By understanding the factors that regulate the immune response to this bacterium, we can design better therapies to treat this disease. ..
  27. Transcription Factor Analysis in a Congenital Diaphragmatic Hernia Model
    Kate G Ackerman; Fiscal Year: 2013
    ..mediated development, as retinoic acid plays a role in both diaphragm and lung development, and retinoic acid receptors interact with Fog2...
  28. Development of ROR ligands for treatment of circadian rhythm disorders
    Thomas P Burris; Fiscal Year: 2013
    ....
  29. Stimulation of tendon repair by retinoid nuclear receptor agonists
    Motomi Enomoto-Iwamoto; Fiscal Year: 2013
    ....
  30. Opoid and Retinoid Interactions in the HIV-1 Transgenic Rat
    Walter Royal; Fiscal Year: 2011
    ..These studies will be useful for better understanding the role of retinoid metabolism and opioids in the pathogenesis of HIV infection in general and, more specifically, in the occurrence of nervous system disease in drug users. ..
  31. MOLECULAR ANALYSIS OF TRANSCRIPTIONAL REPRESSION BY TGIF
    David Wotton; Fiscal Year: 2010
    ..RXR alpha is a partner for several nuclear receptors in addition to retinoic acid receptors, such that a specific inhibitor of RXRfunction will regulate many nuclear receptor pathways...
  32. PTEN IN ONTOGENESIS AND TUMOR SUPPRESSION
    Pier Paolo Pandolfi; Fiscal Year: 2013
    ..This investigation will ultimately lead to a deeper knowledge of the function of PTEN in normal and pathological conditions, facilitating the rational design of novel approaches to cancer prevention and therapy. ..
  33. Molecular Mechanisms of Leukemogenesis by PMLRAR alpha
    Scott C Kogan; Fiscal Year: 2013
    ..The results of the proposed studies should help us to understand acute myeloid leukemia and thereby should aid the development of new treatments for leukemias and other cancers. ..
  34. Development of a High Throughput Screening Assay for RORgamma
    THOMAS BURRIS; Fiscal Year: 2009
    ..This proposal focuses on development of screening assays to identify specific ROR? ligands. Inhibitors of ROR? may be effective for treatment of diseases involving inflammation and autoimmunity. ..
  35. PMLRARalpha and PML directly regulate Fas-mediated apoptosis in vivo
    Felipe Samaniego; Fiscal Year: 2012
    ....
  36. Molecular markers of breast cancer risk and prevention
    Victoria L Seewaldt; Fiscal Year: 2010
    ....
  37. CAROTENOID RICH DIET TRIAL TO REVERSE CIN II
    Cheryl Rock; Fiscal Year: 1999
    ..HPV E6/E7 expression; and to determine if the regression of CIN I and II is associated with expression of retinoic acid receptors (RAR) and/or retinoid X receptors (RXR)...
  38. TISSUE SPECIFIC EXPRESSION AND FUNCTION OF ME-RABP
    Marie Claire Orgebin Crist; Fiscal Year: 2002
    ..The ultimate goal is to provide the basic knowledge for the rational treatment of some forms of male infertility. ..
  39. PROMYELOCYTIC ZINC FINGER GENE
    Jennifer Morris; Fiscal Year: 1999
    ..These biochemical functions will provide the basis for the future development of sensitive diagnostic assays, novel treatments, targets for gene therapy, and assays to monitor residual disease. ..
  40. GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYS
    Gregg Duester; Fiscal Year: 2002
    ..to retinal followed by conversion of retinal to the active ligand retinoic acid which modulates nuclear retinoic acid receptors. The alcohol dehydrogenase (ADH) enzyme family may function in the metabolism of retinol, the alcohol ..
  41. RETINOIDS & RECEPTORS IN BLADDER CANCER CHEMOPREVENTION
    Changping Zou; Fiscal Year: 2003
    ..The effect of different retinoids on cell growth, differentiation, apoptosis, and expression of retinoic acid receptors (RARs) in bladder cancer cell lines and normal bladder epithelial cells in short-term cultures will be ..
  42. REGULATION OF PULMONARY ELASTIN PRODUCTION BY RETINOIDS
    Stephen McGowan; Fiscal Year: 2000
    ..Elucidation of mechanisms whereby elastin synthesis is initiated in the alveoli would provide novel information that may also be applicable to idiopathic pulmonary fibrosis and bronchopulmonary dysplasia. ..
  43. RETINIODS AND INTERMEDIATE BIOMARKERS FOR CIN I AND II
    Mack Ruffin; Fiscal Year: 1999
    ..number of viral genome copies of HPV per cell and inhibits HPV E6/E7 gene expression; 2) To determine if retinoic acid receptors (RAR) and/or retinoid X receptors (RXR) isoform expression change with topical atRA therapy...
  44. THYROID/RETINOIC ACID RECEPTOR INTERACTING PROTEINS
    Mukul Mathur; Fiscal Year: 2004
    ..We will also specify the region on the DNA binding domain of these receptors where these three proteins interact. ..
  45. MECH. OF PEROXISOME PROLIFERATOR ACTION ON TESTIS DEVEL.
    Kwan Kim; Fiscal Year: 2002
    ..Understanding the molecular signaling mechanism may facilitate development of a method to screen for other chemicals that have similar properties as phthalates on the male reproductive system. ..
  46. Gene Regulation for Drug Targeting in AML
    Manohar Ratnam; Fiscal Year: 2009
    ..will continue and expand one major aspect of those studies, the regulation of the FR-beta gene through retinoic acid receptors (RARs) in acute myelogenous leukemia (AML)...
  47. Enhancing Biomedical Research at Tennessee State University
    Terrance L Johnson; Fiscal Year: 2010
    ..Research topics include retinoic acid receptors in neurogenesis in the post-natal olfactory epithelium and inhibition of human natural killer cells by ..
  48. TRANSCRIPTIONAL REGULATION OF RETINOID ACTION
    Paul Nugent; Fiscal Year: 2000
    ..RA is thought to act through specific receptors, the retinoic acid receptors (RARs) and retinoid X receptors (RXRs), that act as sequence-specific DNA-binding transcription factors...
  49. FSH and Retinoid Signaling in the Testis
    Kwan Hee Kim; Fiscal Year: 2009
    ..Three Aims are now tightly focused to provide a critical link between FSH and RAR alpha in the testis. ..
  50. CRANIOFACIAL DEVELOPMENT--ROLE OF VITAMIN A
    Devendra Kochhar; Fiscal Year: 2000
    ..It is hoped that fresh information will be elicited from this new animal model. ..
  51. AUTOANTIGENS AND THE NUCLEAR BODY
    Donald Bloch; Fiscal Year: 2000
    ..4) Determine the clinical significance of autoantibodes directed against components of the NB in patients with PBC. Serum from patients with biopsy-documented PBC will be screened for antibodies directed against the NB. ..
  52. PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA
    Edward Yeh; Fiscal Year: 2004
    ..These studies should provide novel insights into the mechanism and function of sentrinization and increase our understanding of the pathogenesis of acute promyelocytic leukemia. ..
  53. RETINOID RECEPTOR FUNCTION IN SKIN CANCER PROGRESSION
    John Clifford; Fiscal Year: 2002
    ..Retinoids exert their effects primarily through nuclear receptors, retinoic acid receptors (RARalpha, beta and gamma) and retinoid X receptors (RXRalpha, beta and gamma), members of the steroid ..
  54. Mechanism of Alcohol Induced Neurotoxicity
    Ugra Singh; Fiscal Year: 2009
    ..To test this hypothesis we will determine whether (1) ethanol exposure in vivo affects activation of retinoic acid receptors and (2) whether administration of retinoic acid receptor antagonists protect against harmful effects of ..
  55. Mechanism of Retinoid Inhibition of Oral SCC Cell Growth
    KENNETH SOPRANO; Fiscal Year: 2004
    ..be mediated for the most part via unique members of the steroid hormone receptor superfamily, the nuclear retinoic acid receptors (RARs) and the nuclear retinoid X receptors (RXRs)...
  56. BETA-CATENIN AND RAR INTERACT AT THE PKC ALPHA PROMOTER
    Frank Sinicrope; Fiscal Year: 2002
    ..abstract_text> ..
  57. RETINOIC ACID RECEPTORS AND HEMATOPOIESIS
    Steven Collins; Fiscal Year: 2000
    ....
  58. Cross Regulation of Beta-catenin and Retinoid Signaling
    Stephen Byers; Fiscal Year: 2004
    ..In general the work proposed tests the molecular mechanisms, and significance of, cross regulation of beta-catenin/TCF retinoid signaling pathways. ..
  59. ALCOHOL & RETINOID SIGNALING IN TESTIS DEVELOPMENT
    Kwan Kim; Fiscal Year: 2004
    ..is altered retinoid signaling due to alcohol's influence on retinoid metabolism and the function of retinoic acid receptors. The proposed research is designed to better understand the cellular signaling mechanisms by which ..
  60. Analysis of APL-Fusion Retinoic Acid Receptor Proteins
    Shuo Dong; Fiscal Year: 2006
    ..has suggested that these RARalpha fusion receptors cause leukemias by interfering with the function of retinoic acid receptors (RARs)...
  61. Retinoic Acid Receptors: Dynamics, Stability and Folding
    Michael Schimerlik; Fiscal Year: 2006
    Retinoid X receptors (RXR) act as homodimers or heterodimers with retinoic acid receptors (RAR) or other nuclear hormone receptors to regulate gene expression...
  62. Retinoic Acid Receptors: A Novel Therapeutic Target for Cushing's Disease
    ZACHARY BUSH; Fiscal Year: 2009
    ....
  63. HAIR CELL DIFFERENTIATION IN THE ORGAN OF CORTI
    MATTHEW KELLEY; Fiscal Year: 1999
    ..Are other members of the steroid/thyroid family of receptors which can inhibit the response of retinoic acid receptors/thyroid receptors also expressed in regions of the developing sensory epithelium? 2...
  64. PATHWAY OF VENTRICULAR MORPHOGENESIS MEDICATED BY RXRA
    Henry Sucov; Fiscal Year: 2001
    ..abstract_text> ..