ppar delta

Summary

Summary: A nuclear transcription factor. It is activated by PROSTACYCLIN.

Top Publications

  1. pmc Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    Kihwa Kang
    Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Metab 7:485-95. 2008
  2. pmc PPAR delta: a dagger in the heart of the metabolic syndrome
    Grant D Barish
    Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Clin Invest 116:590-7. 2006
  3. ncbi Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation
    David Bishop-Bailey
    Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Pharmacol Ther 124:141-50. 2009
  4. pmc Sorting out the functional role(s) of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in cell proliferation and cancer
    Jeffrey M Peters
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
    Biochim Biophys Acta 1796:230-41. 2009
  5. pmc Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion
    Guy Cohen
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute for Drug Research, Hebrew University, Jerusalem, Israel
    Diabetes 60:2830-42. 2011
  6. ncbi PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes
    Guoliang Ding
    Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
    J Mol Cell Cardiol 40:821-8. 2006
  7. ncbi Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Turin, Italy
    Free Radic Biol Med 50:345-53. 2011
  8. ncbi Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury
    Irene Paterniti
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    J Pharmacol Exp Ther 333:465-77. 2010
  9. pmc Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing
    Han Chung Chong
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    J Cell Biol 184:817-31. 2009
  10. ncbi Peroxisome proliferator-activated receptor (PPAR) beta/delta: a new potential therapeutic target for the treatment of metabolic syndrome
    Teresa Coll
    Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Institut de Biomedicina de la UB University of Barcelona, Diagonal 643, E 08028 Barcelona, Spain
    Curr Mol Pharmacol 2:46-55. 2009

Detail Information

Publications288 found, 100 shown here

  1. pmc Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    Kihwa Kang
    Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Metab 7:485-95. 2008
    ..These findings provide a molecular basis to modulate tissue-resident macrophage activation and insulin sensitivity...
  2. pmc PPAR delta: a dagger in the heart of the metabolic syndrome
    Grant D Barish
    Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Clin Invest 116:590-7. 2006
    ....
  3. ncbi Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation
    David Bishop-Bailey
    Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Pharmacol Ther 124:141-50. 2009
    ..In contrast, the roles of PPARbeta/delta regulating inflammation and immunity are only just emerging. This review will focus on these emerging roles of PPARbeta/delta in regulating inflammatory processes...
  4. pmc Sorting out the functional role(s) of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) in cell proliferation and cancer
    Jeffrey M Peters
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
    Biochim Biophys Acta 1796:230-41. 2009
    ..Suggestions are offered to standardize measurements associated with these studies so that interlaboratory comparisons can be accurately assessed...
  5. pmc Role of lipid peroxidation and PPAR-δ in amplifying glucose-stimulated insulin secretion
    Guy Cohen
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Institute for Drug Research, Hebrew University, Jerusalem, Israel
    Diabetes 60:2830-42. 2011
    ..We aimed at identifying PUFA-derived mediators and their cellular targets that are involved in the amplification of insulin release from β-cells preexposed to high glucose levels...
  6. ncbi PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes
    Guoliang Ding
    Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
    J Mol Cell Cardiol 40:821-8. 2006
    ..Therefore, PPARdelta is an important determinant of TNFalpha expression via the NF-kappaB signaling pathway, thus serving as therapeutic targets to attenuate inflammation that are involved in cardiac pathological progression...
  7. ncbi Peroxisome proliferator-activated receptor β/δ agonism protects the kidney against ischemia/reperfusion injury in diabetic rats
    Massimo Collino
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, Turin, Italy
    Free Radic Biol Med 50:345-53. 2011
    ..Thus, we report herein that PPARβ/δ activation protects the diabetic kidney against I/R injury by a mechanism that may involve changes in renal expression of SOCS-3 resulting in a reduced local inflammatory response...
  8. ncbi Evidence for the role of peroxisome proliferator-activated receptor-beta/delta in the development of spinal cord injury
    Irene Paterniti
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy
    J Pharmacol Exp Ther 333:465-77. 2010
    ..Our results clearly demonstrate that GW0742 treatment reduces the development of inflammation and tissue injury associated with spinal cord trauma...
  9. pmc Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing
    Han Chung Chong
    School of Biological Sciences, Nanyang Technological University, Singapore 637551
    J Cell Biol 184:817-31. 2009
    ..Given the ubiquitous expression of PPARbeta/delta, other epithelial-mesenchymal interactions may also be regulated in a similar manner...
  10. ncbi Peroxisome proliferator-activated receptor (PPAR) beta/delta: a new potential therapeutic target for the treatment of metabolic syndrome
    Teresa Coll
    Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Institut de Biomedicina de la UB University of Barcelona, Diagonal 643, E 08028 Barcelona, Spain
    Curr Mol Pharmacol 2:46-55. 2009
    ..However, clinical trials in humans assessing the efficacy and safety of these drugs should confirm these promising perspectives in the treatment of the metabolic syndrome...
  11. pmc Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2
    Ricardo Rodríguez-Calvo
    Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, Institut de Biomedicina de la UB IBUB and CIBERDEM Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain
    Diabetes 57:2149-57. 2008
    ..It is presently unknown whether peroxisome proliferator-activated receptor (PPAR) beta/delta activation prevents inflammation in adipocytes...
  12. ncbi Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta
    David Kitz Krämer
    Department of Surgical Science, Karolinska Institute, Stockholm, Sweden
    Diabetes 54:1157-63. 2005
    ..Moreover, we provide biological validation of PPARdelta as a potential target for antidiabetic therapy...
  13. ncbi Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate
    Margy L Takacs
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:108-17. 2007
    ....
  14. pmc Ligand activation of peroxisome proliferator-activated receptor-beta/delta inhibits cell proliferation in human HaCaT keratinocytes
    Michael G Borland
    Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, 312 Life Science Building, University Park, PA 16802, USA
    Mol Pharmacol 74:1429-42. 2008
    ....
  15. pmc Regulation of muscle fiber type and running endurance by PPARdelta
    Yong Xu Wang
    Gene Expression Laboratory, Salk Institute, La Jolla, California, USA
    PLoS Biol 2:e294. 2004
    ..These results demonstrate that complex physiologic properties such as fatigue, endurance, and running capacity can be molecularly analyzed and manipulated...
  16. ncbi Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist
    Barry G Shearer
    Department of Metabolic Chemistry, Metabolic Diseases Centre of Excellence for Drug Discovery, GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, North Carolina 27709, USA
    J Med Chem 53:1857-61. 2010
    ..Compound 3 is a PPARdelta antagonist with utility as a tool to elucidate PPARdelta cell biology and pharmacology...
  17. pmc Characterization of the mechanisms of the increase in PPARδ expression induced by digoxin in the heart using the H9c2 cell line
    Zhih Cherng Chen
    Department of Cardiology, Chi Mei Medical Center, Yong Kang City, Tainan County, Taiwan
    Br J Pharmacol 163:390-8. 2011
    ..The aim of the present study was to investigate possible mechanisms for this effect of digoxin using the H9c2 cell line cultured in high glucose (HG) conditions...
  18. pmc The nuclear hormone receptor peroxisome proliferator-activated receptor beta/delta potentiates cell chemotactism, polarization, and migration
    Nguan Soon Tan
    Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 27:7161-75. 2007
    ..The implications of our findings may be far-reaching, considering that the mechanisms described here are important in many physiological and pathological situations...
  19. pmc Reverse crosstalk of TGFβ and PPARβ/δ signaling identified by transcriptional profiling
    Josefine Stockert
    Institute of Molecular Biology and Tumor Research IMT, Philipps University, Marburg, Germany
    Nucleic Acids Res 39:119-31. 2011
    ..These observations indicate that PPARβ/δ is able to influence the expression of distinct sets of both TGFβ-repressed and TGFβ-activated genes in both directions...
  20. pmc Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans
    Harald Staiger
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology, and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany
    Diabetes 58:579-89. 2009
    ..Long-chain fatty acids (LCFAs) contribute to metabolic homeostasis in part via gene regulation. This study's objective was to identify novel LCFA target genes in human skeletal muscle cells (myotubes)...
  21. pmc Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism
    Dongning Pan
    Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 137:73-86. 2009
    ..These findings reveal an unexpected physiological role for twist-1 in the maintenance of energy homeostasis and have important implications for understanding metabolic control and metabolic diseases...
  22. pmc Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes
    Andrew D Burdick
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Huck Institute of Life Sciences, The Pennsylvania State University, University Park 16802, United States
    Cell Signal 19:1163-71. 2007
    ....
  23. ncbi Activation of peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) prevents endothelial dysfunction in type 1 diabetic rats
    Ana María Quintela
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Free Radic Biol Med 53:730-41. 2012
    ..This effect seems to be related to an increase in nitric oxide bioavailability as a result of reduced NADPH oxidase-driven superoxide production and downregulation of prepro endothelin-1...
  24. ncbi High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties
    Simone Naruhn
    Institute of Molecular Biology and Tumor Research IMT, Philipps University, Marburg, Germany
    Mol Pharmacol 80:828-38. 2011
    ..The possibility to differentially modulate specific functions of PPARβ/δ makes these novel compounds invaluable tools to advance our understanding of PPARβ/δ biology...
  25. pmc Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes
    Michael G Borland
    Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
    Cell Signal 23:2039-50. 2011
    ....
  26. ncbi Identification and characterization of a selective peroxisome proliferator-activated receptor beta/delta (NR1C2) antagonist
    Barry G Shearer
    Research and Development, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
    Mol Endocrinol 22:523-9. 2008
    ..Here we describe the first report of a PPARbeta/delta small molecule antagonist ligand. This antagonist ligand will be a useful tool for elucidating the biological roles of PPARbeta/delta...
  27. pmc Peroxisome proliferator-activated receptor β/δ induces myogenesis by modulating myostatin activity
    Sabeera Bonala
    School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
    J Biol Chem 287:12935-51. 2012
    ..Taken together these data revealed that PPARβ/δ is a positive regulator of skeletal muscle myogenesis, which functions through negatively modulating myostatin activity via a mechanism involving Gasp-1...
  28. pmc Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARalpha and PPARdelta
    Pascal J H Smeets
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    J Biol Chem 283:29109-18. 2008
    ..It was shown that both PPARalpha and PPARdelta are able to mitigate cardiomyocyte hypertrophy in vitro by inhibiting NF-kappaB activation...
  29. pmc VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses
    Jonathan D Brown
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e21209. 2011
    ..Previous work has revealed that lipolytic pathways can activate PPARs. Whether hepatic lipase (HL), an enzyme that regulates VLDL and HDL catabolism, participates in PPAR responses is unknown...
  30. ncbi Pharmacological activation of peroxisome proliferator-activated receptor δ improves insulin resistance and hepatic steatosis in high fat diet-induced diabetic mice
    H T Wu
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, ROC
    Horm Metab Res 43:631-5. 2011
    ..Thus, we suggest that pharmacological activation of PPARδ may be a new strategy for the treatment of diabetic patients with hepatic steatosis...
  31. ncbi PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells
    David Alvarez-Guardia
    Department of Pharmacology and Therapeutic Chemistry, Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1811:59-67. 2011
    ..This is relevant, especially taking into account that PPARβ/δ has been postulated as a potential target in the treatment of obesity and the insulin resistance state...
  32. pmc Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) inhibits chemically induced skin tumorigenesis
    Moses T Bility
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, PA 16802, USA
    Carcinogenesis 29:2406-14. 2008
    ..These studies suggest that topical administration of PPARbeta/delta ligands may be useful as both a chemopreventive and/or a chemotherapeutic approach to inhibit skin cancer...
  33. ncbi The expression of both peroxisome proliferator-activated receptor delta and cyclooxygenase-2 in tissues is associated with poor prognosis in colorectal cancer patients
    Masahiro Yoshinaga
    Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, Beppu, Oita, 874 0011, Japan
    Dig Dis Sci 56:1194-200. 2011
    ..The role of peroxisome proliferator-activated receptor delta (PPAR δ) in the development and progression of colorectal cancer (CRC) remains controversial...
  34. ncbi Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress
    Anastasia Georgiadi
    Nutrition, Metabolism and Genomics Group, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Circ Res 106:1712-21. 2010
    ..Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact heart...
  35. pmc Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Am J Pathol 177:1834-47. 2010
    ..These data suggest that PPARδ is a crucial anti-inflammatory regulator, providing a basis for novel sepsis therapies...
  36. ncbi Regulation of skeletal muscle physiology and metabolism by peroxisome proliferator-activated receptor delta
    Ewa Ehrenborg
    Atherosclerosis Research Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Pharmacol Rev 61:373-93. 2009
    ..In this review we summarize the current status regarding the regulation, and the metabolic effects, of PPARdelta in skeletal muscle...
  37. ncbi Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle
    David Kitz Krämer
    Department of Molecular Medicine, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Biol Chem 282:19313-20. 2007
    ..In conclusion, the PPARdelta agonist GW501516 promotes changes in lipid/glucose metabolism and gene expression in human skeletal muscle cells by PPARdelta- and AMPK-dependent and -independent mechanisms...
  38. ncbi PPARdelta enhances keratinocyte proliferation in psoriasis and induces heparin-binding EGF-like growth factor
    Malgorzata Romanowska
    Department of Biology, Free University of Berlin, Berlin, Germany
    J Invest Dermatol 128:110-24. 2008
    ..The present data suggest that activation of PPARdelta is a major event in psoriasis, contributing to the hyperproliferative phenotype by induction of HB-EGF...
  39. ncbi Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) acts as regulator of metabolism linked to multiple cellular functions
    Kay Dietrich Wagner
    INSERM U907, 06107 Nice, France
    Pharmacol Ther 125:423-35. 2010
    ..We will focus here on functions of PPARbeta in adipose tissue, skeletal muscle, heart, angiogenesis and cancer related to modifications in metabolism and the identified underlying molecular mechanisms...
  40. ncbi A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease
    Sergey Kalinin
    Department of Anethesiology, University of Illinois, and Jesse Brown Veterans Affairs Hospital, Chicago, IL 60612, USA
    Curr Alzheimer Res 6:431-7. 2009
    ..These results suggest that, as found for some PPARgamma agonists, PPARdelta agonists can also reduce amyloid burden likely to be mediated by effects on amyloid clearance...
  41. ncbi 15-hydroxyeicosatetraenoic acid is a preferential peroxisome proliferator-activated receptor beta/delta agonist
    Simone Naruhn
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, 35032 Marburg, Germany
    Mol Pharmacol 77:171-84. 2010
    ..Both 15R-HETE and 15S-HETE are similarly potent at inducing PPARbeta/delta coactivator binding and transcriptional activation, indicating that 15-HETE enantiomers generated by different pathways function as PPARbeta/delta agonists...
  42. pmc Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity
    Shannon E Dunn
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    J Exp Med 207:1599-608. 2010
    ..Collectively, these findings suggest that PPAR-delta serves as an important molecular brake for the control of autoimmune inflammation...
  43. ncbi Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity
    Alejandro Gallardo-Soler
    Departamento de Bioquimica y Biologia Molecular y Genetica, Universidad de Extremadura Avenida de la Universidad s n, 10071 Caceres, Spain
    Mol Endocrinol 22:1394-402. 2008
    ..Collectively, our results strongly suggest that ArgI is a key marker of the alternative program triggered by PPAR in macrophages...
  44. ncbi Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes
    Serge Luquet
    Inserm U636, Centre de Biochimie, UFR Sciences, Universite de Nice Sophia Antipolis, Parc Valrose, 06108 Nice, France
    Biochim Biophys Acta 1740:313-7. 2005
    ..Given the results obtained with animal models, PPARdelta agonists may have therapeutic usefulness in metabolic syndrome by increasing fatty acid consumption in skeletal muscle and adipose tissue...
  45. ncbi Peroxisome proliferator-activated receptor {delta} regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta}1/Smad3
    Hyo Jung Kim
    Department of Pharmacology, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Chilam Dong, Jinju, Korea
    Circ Res 105:16-24. 2009
    ..Specific ligands of PPARdelta may aid in the therapeutic intervention of atherosclerosis by improving plaque stability and patient prognosis...
  46. ncbi The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice
    Tracey L Graham
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Atherosclerosis 181:29-37. 2005
    ..Changes in gene expression were reflected in decreased plasma levels of MCP-1. These observations support an atheroprotective effect of PPARdelta agonists in vivo...
  47. pmc Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis
    Jeffrey M Peters
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
    Cancer Metastasis Rev 30:619-40. 2011
    ..This review examines studies reporting the role of PPARβ/δ in colon, breast, and lung cancers. The prevailing evidence would suggest that targeting PPARβ/δ is not only safe but could have anti-carcinogenic protective effects...
  48. ncbi Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Biol Chem 282:37770-82. 2007
    ..This study is clinically relevant because deferral of on time implantation leads to spontaneous pregnancy loss, and defective trophoblast invasion is one cause of preeclampsia in humans...
  49. ncbi Quantitative analysis of PPARdelta mRNA by real-time RT-PCR in 86 rectal cancer tissues
    L Yang
    Department of General Surgery and Division of Digestive Surgery and Organ Microcirculation, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    Eur J Surg Oncol 32:181-5. 2006
    ..The purpose of this study is to clarify the expression change of PPARdelta gene in human colorectal cancer tissues...
  50. ncbi PPARβ/δ governs Wnt signaling and bone turnover
    Carina Scholtysek
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nurnberg, Erlangen, Germany
    Nat Med 19:608-13. 2013
    ..Our findings identify PPARβ/δ as a promising target for an alternative approach in the treatment of osteoporosis and related diseases...
  51. pmc Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage
    Chih Hao Lee
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:2434-9. 2006
    ....
  52. ncbi Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids
    Stewart A Fyffe
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Mol Biol 356:1005-13. 2006
    ....
  53. ncbi Oral administration of a PPAR-delta agonist to rodents worsens, not improves, maximal insulin-stimulated glucose transport in skeletal muscle of different fibers
    Justin Cresser
    Dept of Human Health and Nutritional Sciences, Univ of Guelph, Ontario, Canada, N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 299:R470-9. 2010
    ..However, an accumulation of diacylglycerol and ceramide, while associated with diet-induced insulin resistance, does not appear to be responsible for the agonist-induced reduction in insulin-stimulated glucose transport...
  54. ncbi Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferator-activated receptor-delta -87T>C polymorphism and dietary fat in French-Canadians
    J Robitaille
    Lipid Research Center, CHUQ CHUL Pavilion, Ste Foy, Quebec, Canada
    Int J Obes (Lond) 31:411-7. 2007
    ..We verified whether genetic variants in this gene are associated with the MS and whether dietary fatty acids interact with the -87T>C polymorphism...
  55. ncbi The peroxisome proliferator-activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1
    Emma Barroso
    Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, Institut de Biomedicina de la UB IBUB, Spain
    Biochem Pharmacol 81:534-43. 2011
    ....
  56. ncbi Decrease of peroxisome proliferator-activated receptor delta expression in cardiomyopathy of streptozotocin-induced diabetic rats
    Bu Chin Yu
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, ROC
    Cardiovasc Res 80:78-87. 2008
    ..Thus, we investigated the effect of hyperglycaemia-induced oxidative stress on the expression of cardiac PPARdelta both in vivo and in vitro...
  57. pmc Quantitative expression patterns of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) protein in mice
    Elizabeth E Girroir
    Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, 312 Life Sciences Building, University Park, PA 16802, USA
    Biochem Biophys Res Commun 371:456-61. 2008
    ..Results from these studies demonstrate that PPARbeta/delta expression is highest in intestinal epithelium, liver, and keratinocytes, consistent with significant biological roles in these tissues...
  58. ncbi Short-term activation of peroxysome proliferator-activated receptor beta/delta increases fatty acid oxidation but does not restore insulin action in muscle cells from type 2 diabetic patients
    Cyrille Debard
    INSERM U 449, INRA U 1235, R Laennec Faculty of Medicine, Human Nutrition Research Center, Claude Bernard Lyon 1 University, Rue G Paradin, 69372, Lyon, Cedex 08, France
    J Mol Med (Berl) 84:747-52. 2006
    ..This suggests that additional studies are needed to better characterize the link between fatty acid oxidation and insulin sensitivity in humans...
  59. ncbi Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells
    Anke Gutgesell
    Institute of Agricultural and Nutritional Sciences, Martin Luther Universitat Halle Wittenberg, Von Danckelmann Platz 2, 06120 Halle, Saale, Germany
    Biochim Biophys Acta 1790:1206-16. 2009
    ....
  60. pmc GW501516, a PPARδ agonist, ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice
    Xu Yang
    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan
    PLoS ONE 6:e25271. 2011
    ..In conclusion, we demonstrate that GW501516 has an anti-inflammatory effect in renal tubular cells and may serve as a therapeutic candidate to attenuate tubulointerstitial lesions in proteinuric kidney diseases...
  61. pmc Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes
    Lucía Serrano-Marco
    Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, University of Barcelona, Institut de Biomedicina de la UB IBUB, Barcelona, Spain
    Diabetes 60:1990-9. 2011
    ..We evaluated whether peroxisome proliferator-activated receptor (PPAR)-β/-δ prevented activation of the IL-6-STAT3-SOCS3 pathway and insulin resistance in adipocytes...
  62. pmc Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)
    Till Adhikary
    Institute of Molecular Biology and Tumor Research, Philipps University, Marburg, Germany
    PLoS ONE 6:e16344. 2011
    ..These observations have important implications for understanding the regulatory PPAR network and PPARβ/δ ligand-based drugs...
  63. ncbi Variation in the peroxisome proliferator-activated receptor delta gene in relation to common metabolic traits in 7,495 middle-aged white people
    N Grarup
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 14, 2820 Gentofte, Copenhagen, Denmark
    Diabetologia 50:1201-8. 2007
    ..Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Thus, we hypothesised that common variation in the PPARD gene is associated with insulin resistance and metabolic traits...
  64. pmc Peroxisome proliferator-activated receptor delta +294T > C polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations
    Lin Miao
    Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, People s Republic of China
    Lipids Health Dis 9:145. 2010
    ..The present study was undertaken to detect the association of PPARD +294T > C (rs2016520) polymorphism and several environmental factors with serum lipid levels in the Guangxi Bai Ku Yao and Han populations...
  65. ncbi Comparison of PPARδ and PPARγ in inhibiting the pro-inflammatory effects of C-reactive protein in endothelial cells
    Yao Jen Liang
    Department and Institute of Life Science, Fu Jen Catholic University, and Department of Medical Education and Research, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    Int J Cardiol 143:361-7. 2010
    ..Recently, PPARδ has revealed benefits for dealing with inflammation. The relationship between CRP-induced inflammation and PPARδ agonist remains unclear...
  66. ncbi The role of PPARβ/δ in the management of metabolic syndrome and its associated cardiovascular complications
    Elisa Benetti
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, via P Giuria 9, 10125 Torino, Italy
    Endocr Metab Immune Disord Drug Targets 11:273-84. 2011
    ..This paper reviews the evidence and recent developments relating to the potential therapeutic effects of PPARβ/δ agonists in the treatment of metabolic syndrome and its associated cardiovascular risk factors...
  67. ncbi Reevaluation of the PPAR-beta/delta ligand binding domain model reveals why it exhibits the activated form
    Stewart A Fyffe
    Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell 21:1-2. 2006
  68. pmc Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin
    Tongrong He
    Mayo Clinic, Joseph Building 4 184, 200 First St SW, Rochester, MN 55905, USA
    Hypertension 58:287-94. 2011
    ..Thus, in human EPCs, activation of PPARδ stimulates expression and activity of GTPCH I and biosynthesis of tetrahydrobiopterin via PTEN-AKT signaling pathway. This effect enhances the regenerative function of EPCs...
  69. pmc CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress
    Zaher Nahle
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 283:14317-26. 2008
    ..The findings could have implications in the chronic abnormalities of fatty acid metabolism associated with obesity and diabetes...
  70. pmc PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance
    Lata Mukundan
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Nat Med 15:1266-72. 2009
    ..Thus, PPAR-delta has a pivotal role in orchestrating the timely disposal of apoptotic cells by macrophages, ensuring that tolerance to self is maintained...
  71. pmc The natural protective mechanism against hyperglycemia in vascular endothelial cells: roles of the lipid peroxidation product 4-hydroxydodecadienal and peroxisome proliferator-activated receptor delta
    Yael Riahi
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
    Diabetes 59:808-18. 2010
    ..The hypothesis that 4-hydroxydodeca-(2E,6Z)-dienal (4-HDDE), the peroxidation product of 12-lipoxygenase, mediates this downregulatory mechanism by activating peroxisome proliferator-activated receptor (PPAR) delta was investigated...
  72. pmc Shear stress induces synthetic-to-contractile phenotypic modulation in smooth muscle cells via peroxisome proliferator-activated receptor alpha/delta activations by prostacyclin released by sheared endothelial cells
    Min Chien Tsai
    Division of Medical Engineering Research, National Health Research Institutes, Miaoli 350, Taiwan
    Circ Res 105:471-80. 2009
    ..The role of flow-induced shear stress in the modulation of SMC phenotype has not been well defined...
  73. ncbi Activation of PPARdelta up-regulates fatty acid oxidation and energy uncoupling genes of mitochondria and reduces palmitate-induced apoptosis in pancreatic beta-cells
    Jun Wan
    Department of Endocrinology, West China Hospital of Sichuan University, 37 Guoxue Lane, Chengdu, Sichuan 610041, China
    Biochem Biophys Res Commun 391:1567-72. 2010
    ..These results suggest that activation of PPARdelta plays an important role in protecting pancreatic beta-cells against aberrations caused by lipotoxicity in metabolic syndrome and diabetes...
  74. ncbi WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Cell Cycle 3:1512-5. 2004
    ..By contrast, antagonists of PPARdelta may provide a novel approach for prevention and treatment of colorectal cancer...
  75. pmc Association study of Wnt signaling pathway genes in bipolar disorder
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Hampton House, Room 857, 624 N Broadway, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 65:785-93. 2008
    ..The Wnt signaling pathways promote cell growth and are best known for their role in embryogenesis and cancer. Several lines of evidence suggest that these pathways might also be involved in bipolar disorder...
  76. ncbi PPAR agonists: multimodal drugs for the treatment of type-2 diabetes
    Barbara Gross
    Institut Pasteur de Lille, 1 rue du Prof Calmette, Lille, F 59019, France
    Best Pract Res Clin Endocrinol Metab 21:687-710. 2007
    ..This chapter focuses on the PPAR agonists currently used in the clinic, as well as on the discovery and development of the next generation of PPAR agonists...
  77. ncbi Association of the CYBA, PPARGC1A, PPARG3, and PPARD gene variants with coronary artery disease and metabolic risk factors of coronary atherosclerosis in a Russian population
    Alexey G Nikitin
    Department of Molecular Diagnostics, National Research Center GosNIIgenetika, 1st Dorozhny Proezd 1, 117545 Moscow, Russia
    Heart Vessels 25:229-36. 2010
    ..In conclusion, the CYBA +242C/T and PPARD +294T/C variants modulate risk of CAD through their associations with atherogenic serum lipid profiles...
  78. ncbi BCL-6: a possible missing link for anti-inflammatory PPAR-delta signalling in pancreatic beta cells
    I Kharroubi
    Laboratory of Experimental Medicine, Universite Libre de Bruxelles, CP 618, 808 Route de Lennik, Brussels, 1070, Belgium
    Diabetologia 49:2350-8. 2006
    ..PPAR-delta controls cellular lipid metabolism and is a major regulator of inflammatory responses. We therefore examined the role of PPAR-delta in cytokine-treated beta cells...
  79. pmc Transcriptional profiling identifies functional interactions of TGF β and PPAR β/δ signaling: synergistic induction of ANGPTL4 transcription
    Kerstin Kaddatz
    Institute of Molecular Biology and Tumor Research, Philipps University, Emil Mannkopff Strasse 2, 35032 Marburg, Germany
    J Biol Chem 285:29469-79. 2010
    ..Although the PPAR-E is not regulated by TGFβ, it interacts with SMAD3, ETS1, RUNX2, and AP-1 in vivo, providing a possible mechanistic explanation for the observed synergism...
  80. ncbi In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats
    Tian Li Yue
    Department of Cardiac Biology, GlaxoSmithKline, 709 Swedeland Rd, King of Prussia, PA 19406, USA
    J Pharmacol Exp Ther 325:466-74. 2008
    ....
  81. ncbi Ligand-mediated regulation of peroxisome proliferator-activated receptor (PPAR) beta/delta: a comparative analysis of PPAR-selective agonists and all-trans retinoic acid
    Markus Rieck
    Institute of Molecular Biology and Tumor Research, Philipps University, 35032 Marburg, Germany
    Mol Pharmacol 74:1269-77. 2008
    ....
  82. pmc Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis
    Saravanan Kanakasabai
    Neuroscience Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Immunology 130:572-88. 2010
    ..These findings indicate that PPARdelta agonists modulate Th1 and Th17 responses in EAE and suggest their use in the treatment of MS and other autoimmune diseases...
  83. ncbi [PPARdelta + 294T/C gene polymorphism related to plasma lipid, obesity and left ventricular hypertrophy in subjects with metabolic syndrome]
    Zhen Cheng Yan
    Department of Hypertension and Endocrinology, Chongqing Institute of Hypertension, Daping Hospital, Third Military Medical University, Chongqing 400042, China
    Zhonghua Xin Xue Guan Bing Za Zhi 33:529-33. 2005
    ..To investigate the relationship between PPARdelta + 294T/C gene polymorphism and lipid profile, obesity and left ventricular hypertrophy (LVH) in patients with metabolic syndrome (MS)...
  84. ncbi Activation of PPAR-delta in isolated rat skeletal muscle switches fuel preference from glucose to fatty acids
    B Brunmair
    Department of Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Diabetologia 49:2713-22. 2006
    ..We explored such actions further in isolated rat skeletal muscle...
  85. pmc Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Cell Metab 7:496-507. 2008
    ..Taken together, these data suggest an unexpected beneficial role for alternatively activated Kupffer cells in metabolic syndrome and type 2 diabetes...
  86. pmc Alternative splicing of human peroxisome proliferator-activated receptor delta (PPAR delta): effects on translation efficiency and trans-activation ability
    Kerstin Lundell
    The Atherosclerosis Research Unit, King Gustaf V Research Institute, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    BMC Mol Biol 8:70. 2007
    Peroxisome proliferator-activated receptor delta (PPAR delta) is a member of the nuclear receptor superfamily...
  87. ncbi Unlike PPARgamma, PPARalpha or PPARbeta/delta activation does not promote human monocyte differentiation toward alternative macrophages
    Mohamed Amine Bouhlel
    Univ Lille Nord de France, F 59000 Lille, France
    Biochem Biophys Res Commun 386:459-62. 2009
    ..Thus, PPARalpha and PPARbeta/delta do not appear to modulate the alternative differentiation of human macrophages...
  88. pmc Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons
    Alexander Tenenbaum
    Cardiac Rehabilitation Institute, Sheba Medical Center, 52621 Tel Hashomer, Israel
    Cardiovasc Diabetol 4:14. 2005
    ..However, treatment of obese animals by specific PPAR delta agonists results in normalization of metabolic parameters and reduction of adiposity...
  89. pmc PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction
    Kim Ravnskjaer
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark
    J Lipid Res 51:1370-9. 2010
    ..As maintenance of mitochondrial metabolism is essential to preserve beta-cell function, these data indicate that dietary or pharmacological activation of PPARdelta and RXR may be beneficial in the prevention of beta-cell dysfunction...
  90. pmc High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes
    Yuquan Li
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd, Birmingham, AL 35294 3360, USA
    J Mol Cell Cardiol 47:536-43. 2009
    ..Increased lipid intake activates cardiac expression of FAO genes via PPARalpha/PGC-1alpha pathway, albeit it is not sufficient to improve cardiac pathology due to PPARdelta deficiency...
  91. ncbi PPARdelta and PGC1alpha act cooperatively to induce haem oxygenase-1 and enhance vascular endothelial cell resistance to stress
    Faisal Ali
    Bywaters Center for Vascular Inflammation, Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Cardiovasc Res 85:701-10. 2010
    ..We investigated the role of PPARdelta and its co-activator, PPARgamma co-activator 1alpha (PGC1alpha), in vasculoprotection against oxidant-induced injury via induction of haem oxygenase-1...
  92. pmc Peroxisome proliferator-activated receptor β/δ cross talks with E2F and attenuates mitosis in HRAS-expressing cells
    Bokai Zhu
    Department of Veterinary and Biomedical Sciences and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania, USA
    Mol Cell Biol 32:2065-82. 2012
    ....
  93. pmc Ligand modulated antagonism of PPARgamma by genomic and non-genomic actions of PPARdelta
    Mattias C U Gustafsson
    Biomedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, United Kingdom
    PLoS ONE 4:e7046. 2009
    ..Non-agonist bound PPARdelta has been shown to repress PPAR Response Element, PPRE, signalling and several lines of evidence point to the importance of PPARdelta repressive actions in both cardiovascular and cancer biology...
  94. ncbi Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne?
    M Schuster
    Department of Dermatology, Venereology and Allergology, University Hospital, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt Main 60590, Germany
    Br J Dermatol 164:182-6. 2011
    ..As peroxisome proliferator-activated receptors (PPARs) are known to control lipid metabolism in several human tissues they have been considered to be involved in the pathogenesis of acne vulgaris...
  95. ncbi Peroxisome proliferator-activated receptor delta agonists attenuated the C-reactive protein-induced pro-inflammation in cardiomyocytes and H9c2 cardiomyoblasts
    Yao Jen Liang
    Department and Institute of Life Science, Fu Jen Catholic University, Taipei, Taiwan
    Eur J Pharmacol 643:84-92. 2010
    ..However, PPARdelta activation attenuated CRP-induced NF-kappaB pathway may be independent of CD32. These results may provide new evidence of PPARdelta beneficial effects for inflammatory cardiomyopathy...
  96. pmc Ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase-2 enhances inhibition of skin tumorigenesis
    Moses T Bility
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Toxicol Sci 113:27-36. 2010
    ..Results from these studies support the hypothesis that combining ligand activation of PPARbeta/delta with inhibition of COX-2 activity can inhibit chemically induced skin tumor progression by modulating differentiation...
  97. ncbi Transcriptional up-regulation of antioxidant genes by PPARδ inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells
    Hyo Jung Kim
    Department of Pharmacology, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, South Korea
    Biochem Biophys Res Commun 406:564-9. 2011
    ..Taken together, the enhanced transcription of antioxidant genes is responsible for the PPARδ-mediated inhibition of premature senescence through sequestration of ROS in hVSMCs treated with Ang II...
  98. ncbi Signaling pathways in skeletal muscle remodeling
    Rhonda Bassel-Duby
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148
    Annu Rev Biochem 75:19-37. 2006
    ..Understanding the mechanisms involved in modulating skeletal muscle phenotypes can potentiate the development of new therapeutic measures to ameliorate muscular diseases...
  99. pmc Role of peroxisome-proliferator-activated receptor beta/delta (PPARbeta/delta) in gastrointestinal tract function and disease
    Jeffrey M Peters
    Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, PA 16802, USA
    Clin Sci (Lond) 115:107-27. 2008
    ..In the present review, we summarize the role of PPARbeta/delta in gastrointestinal physiology and disease with an emphasis on findings in experimental models using both high-affinity ligands and null-mouse models...
  100. pmc Regulation of Wnt/beta-catenin pathway by cPLA2alpha and PPARdelta
    Chang Han
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cell Biochem 105:534-45. 2008
    ..These results depict a novel interaction linking cPLA(2)alpha, PPARdelta and Wnt/beta-catenin signaling pathways and provide insight for further understanding the roles of these key molecules in human cells and diseases...
  101. pmc Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205 M, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 40:325-31. 2009
    ..This study unveils a novel mechanism by which GW501516 and activation of PPARbeta/delta stimulate human lung carcinoma cell proliferation, and suggests that activation of AMPKalpha may oppose this effect...

Research Grants42

  1. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert I Glazer; Fiscal Year: 2010
    ..The influence of PDK1 and PPARtf transaene expression on Sca-1 M mammary stem cells will also be evaluated. ..
  2. The PPAR-delta pathway in neural function and Hungtington's disease neuropatholog
    Albert R La Spada; Fiscal Year: 2013
    ....
  3. PPAR delta functions in liver
    Chih Hao Lee; Fiscal Year: 2013
    ..The study is expected to lead to new areas of research and to have important clinical implication, as this novel lipid signaling may serve as a marker and a therapeutic target of metabolic diseases. ..
  4. FINR: A Novel Modulator of Insulin Signaling
    Marc R Montminy; Fiscal Year: 2010
    ..in oxidative but not glycolytic fibers, focusing on the potential involvement of the nuclear hormone receptor PPAR delta and the coactivator PGC1a in this process...
  5. 15-LOX-1 effects on colitis and colon cancer
    Imad Shureiqi; Fiscal Year: 2012
    ..This improved understanding is expected to facilitate the identification of molecular targets for new strategies for colon cancer prevention. ..
  6. Nuclear receptor mechanisms controlling macrophage function in health and disease
    Ajay Chawla; Fiscal Year: 2013
    ..Our preliminary data indicate the nuclear receptors PPAR delta and gamma play a key role in orchestrating macrophage transcriptional programs necessary for debris clearance ..
  7. Molecular targeting of PPAR-delta in colon cancer
    Imad Shureiqi; Fiscal Year: 2013
    ..Confirmation of the tested hypothesis could lead to developing PPAR-d-targeted therapy to inhibit tumorigenesis. ..
  8. Modulation of the PPAR-delta Signaling Pathway in Huntingtons Disease
    Audrey S Dickey; Fiscal Year: 2013
    ..By elucidating the role of the PPAR [unreadable] signaling pathway in HD, targets for treatment may be found not only for HD, but other polyglutamine diseases and neurodegenerative diseases. ..
  9. Hepatic Lipase, PPAR-delta and Fatty Acid Metabolism
    JONATHAN DAVID BROWN; Fiscal Year: 2013
    ..abstract_text> ..
  10. Stratum Corneum Acidification in the Neonate
    Kenneth Feingold; Fiscal Year: 2007
    ..develop, and the SC ultimately acidifies, a process that can be accelerated by activation of PPAR alpha, PPAR delta, and LXR...
  11. RXR-Heterodimeric Receptors in the GI Tract
    Ellen Li; Fiscal Year: 2006
    ..We propose to study intraheterodimerization interactions between RXR and the minimal peptide by nuclear magnetic resonance techniques. ..
  12. PHASE II CLINICAL TRAIL - AN EXPLORATORY STUDY TO IDENTI
    Karen Lu; Fiscal Year: 2000
    ..Retinoids and Related Growth Regulators - RALDH2, RAR-beta, RaOH, PPAR delta 3. Oncogenes and Tumor Suppressor Genes - K-ras and PTEN 4. Microstatellite Instability 5...
  13. PPAR-delta in obesity-related vascular remodeling
    Yuqing Chen; Fiscal Year: 2007
    ..Define the essential role of PPARdelta as a "vasculopathic" determinant in obesity-related vascular disease in vivo. ..
  14. Role of PPAR-delta in Duchenne Muscular Dystrophy
    Vihang Narkar; Fiscal Year: 2008
    ..The results from our study will reveal whether PPAR-delta is an appropriate target to counteract DMD as well as whether an orally active PPAR-delta agonist can decrease the pathology of DMD. [unreadable] [unreadable] [unreadable]..
  15. Modulation of AhR-dependent signaling by PPARb/d
    Jeffrey M Peters; Fiscal Year: 2010
    ..abstract_text> ..
  16. Role of the PPARb in epithelial cell proliferation
    Jeffrey Peters; Fiscal Year: 2004
    ....
  17. Role of PPARbeta in colon carcinogenesis
    Jeffrey Peters; Fiscal Year: 2007
    ..abstract_text> ..
  18. Lipolytic Mechanisms of PPAR Activation
    Jorge Plutzky; Fiscal Year: 2007
    ..Through these programmatic efforts, insight will be gained into lipolysis as a mechanism for selective endogenous PPAR activation, and its distal transcriptional effects. ..
  19. Endogenous Mechanisms of PPAR Modulation
    Jorge Plutzky; Fiscal Year: 2005
    ..Together, these studies integrate biochemical, biologic, and in vivo models to better understand how endogenous modulation of PPAR activity may determine biologic responses. ..
  20. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  21. Mechanisms linking the adipogenic phenotype of aging muscle to insulin resistance
    Deborah M Muoio; Fiscal Year: 2010
    ....
  22. Structural Biology of Class B G-Protein Coupled Receptors
    H Eric Xu; Fiscal Year: 2010
    ..PHS 398/2590 (Rev. 11/07) Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): Xu, H. Eric ..
  23. Structural and functional studies of the nuclear receptor PPARgamma
    H Eric Xu; Fiscal Year: 2010
    ....
  24. Structure and Functions of Steroid Hormone Receptors
    H Eric Xu; Fiscal Year: 2010
    ..abstract_text> ..
  25. Tetrahydrobiopterin: Regulator of Endothelial Function
    ZVONIMIR KATUSIC; Fiscal Year: 2009
    ..This information may help to develop new strategies in prevention and treatment of endothelial dysfunction. . ..
  26. Mid-Atlantic Microbial Pathogenesis Meeting(Conference)
    ROY ROOP; Fiscal Year: 2003
    ..A dedicated website (www.ecu.edu/mampm) has also been established to publicize the meeting and provide the necessary information and forms required for registration. ..
  27. BRUCELLA STATIONARY PHASE GENE EXPRESSION AND VIRULENCE
    ROY M ROOP; Fiscal Year: 2010
    ..abortus 2308. ..
  28. Brucella Iron Metabolism in Host Macrophages
    ROY M ROOP; Fiscal Year: 2010
    ..abstract_text> ..
  29. LINOLEIC ACID METABOLISM AND COLON CARCINOGENESIS
    Imad Shureiqi; Fiscal Year: 2005
    ..This work will set the stage for future animals and clinical studies of LA alternative pathway modulation as means of colon cancer chemoprevention. ..
  30. Nitric Oxide-Superoxide in Lipid Induced Vascular Diseas
    ZVONIMIR KATUSIC; Fiscal Year: 2005
    ....
  31. CEREBAL ARTERIAL ADVENTITIA AND VASOSPASM
    ZVONIMIR KATUSIC; Fiscal Year: 2001
    ..Our studies will also expand the knowledge base concerning the vascular biology of adventitia, and its role as a target for transfer and expression of therapeutically beneficial recombinant proteins. ..
  32. Ketone Dysregulation and Muscle Insulin Resistance
    DEBORAH MUOIO; Fiscal Year: 2006
    ..abstract_text> ..
  33. PPARs: Transcriptional Regulators of Metabolism
    Ronald Evans; Fiscal Year: 2003
    ..It is believed that this synergy will push this exciting field forward at an accelerated pace. ..
  34. Translational Cardiovascular Science and Medicine
    Ronald Evans; Fiscal Year: 2007
    ....
  35. Molecular Targeting of 15-Lipoxygenase-1 in Colon Cancer
    Imad Shureiqi; Fiscal Year: 2007
    ..the feasibility of tumor selective targeting of 15-LOX-1 to inhibit tumorigenesis will pave the way for future preclinical and clinical development of therapeutic strategies based on molecularly targeting 15-LOX-1 ..
  36. 5-LOX-1 and Clinical Chemoprevention of Colon Tumors
    Imad Shureiqi; Fiscal Year: 2008
    ..If our hypothesis is confirmed, efforts can be directed to develop chemopreventive interventions that specifically target the GATA-6 and 15-LOX-1 signaling pathway. ..
  37. Mitochrondrial Dysfunction: Role in Metabolic Syndrome
    Gerald Shulman; Fiscal Year: 2008
    ..The program is coordinated by frequent meetings of the program faculty and research workers bdnging together these diverse approaches to address a common goal. ..
  38. SPATIAL REGULATION OF DEVELOPMENTAL GENE EXPRESSION
    Ronald Evans; Fiscal Year: 2009
    ....
  39. ETHANOL, INSULIN/IGF SIGNALING AND NEURONAL MIGRATION
    Suzanne de la Monte; Fiscal Year: 2008
    ..abstract_text> ..
  40. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..abstract_text> ..
  41. PPARs in Atherosclerosis and Immunity
    GRANT BARISH; Fiscal Year: 2006
    ..Such insights may also be relevant to the inflammatory roles of PPARs in atherosclerosis. ..
  42. COLLABORATIVE R01
    Rhonda Bassel Duby; Fiscal Year: 2002
    ..In this iterative manner, the investigators expect to gain knowledge that ultimately will foster the development of cell transplantation strategies to promote myocardial repair in human patients afflicted with heart failure. ..