myogenic regulatory factors

Summary

Summary: A family of muscle-specific transcription factors which bind to DNA in control regions and thus regulate myogenesis. All members of this family contain a conserved helix-loop-helix motif which is homologous to the myc family proteins. These factors are only found in skeletal muscle. Members include the myoD protein (MYOD PROTEIN); MYOGENIN; myf-5, and myf-6 (also called MRF4 or herculin).

Top Publications

  1. ncbi Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 75390 9148, USA
    Nature 408:106-11. 2000
  2. ncbi Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
    Chun Li Zhang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas 75390, USA
    Cell 110:479-88. 2002
  3. pmc Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection
    Steven W Flavell
    FM Kirby Neurobiology Center, Children s Hospital, and Department of Neurology and Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 60:1022-38. 2008
  4. ncbi Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases
    J Lu
    Department of Molecular Biology, University of Texas, Southwestern Medical Center at Dallas, 75235, USA
    Mol Cell 6:233-44. 2000
  5. ncbi MEF2: a calcium-dependent regulator of cell division, differentiation and death
    Timothy A McKinsey
    Dept of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Trends Biochem Sci 27:40-7. 2002
  6. ncbi A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development
    Thomas Sandmann
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Dev Cell 10:797-807. 2006
  7. pmc Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 97:14400-5. 2000
  8. ncbi Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins
    B L Black
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
    Annu Rev Cell Dev Biol 14:167-96. 1998
  9. pmc Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2
    Serge Gregoire
    Molecular Oncology Group, Royal Victoria Hospital, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Mol Cell Biol 27:1280-95. 2007
  10. ncbi Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C
    Q Lin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9148, USA
    Science 276:1404-7. 1997

Research Grants

Detail Information

Publications277 found, 100 shown here

  1. ncbi Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 75390 9148, USA
    Nature 408:106-11. 2000
    ....
  2. ncbi Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
    Chun Li Zhang
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas 75390, USA
    Cell 110:479-88. 2002
    ..Thus, class II HDACs act as signal-responsive suppressors of the transcriptional program governing cardiac hypertrophy and heart failure...
  3. pmc Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection
    Steven W Flavell
    FM Kirby Neurobiology Center, Children s Hospital, and Department of Neurology and Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 60:1022-38. 2008
    ..Taken together, these analyses suggest that the ubiquitously expressed transcription factor MEF2 regulates an intricate transcriptional program in neurons that controls synapse development...
  4. ncbi Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases
    J Lu
    Department of Molecular Biology, University of Texas, Southwestern Medical Center at Dallas, 75235, USA
    Mol Cell 6:233-44. 2000
    ..These findings reveal central roles for HDACs in chromatin remodeling during myogenesis and as intranuclear targets for signaling pathways controlled by IGF and CaM kinase...
  5. ncbi MEF2: a calcium-dependent regulator of cell division, differentiation and death
    Timothy A McKinsey
    Dept of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Trends Biochem Sci 27:40-7. 2002
    ..This article describes the post-translational mechanisms that confer calcium-sensitivity to MEF2 and its downstream target genes, and considers how this transcription factor can control diverse and mutually exclusive cellular decisions...
  6. ncbi A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development
    Thomas Sandmann
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Dev Cell 10:797-807. 2006
    ..The number and diversity of new direct target genes indicates a much broader role for Mef2, at all stages of myogenesis, than previously anticipated...
  7. pmc Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 97:14400-5. 2000
    ..Our studies suggest that 14-3-3 binding to HDAC5 is required for CaMK-dependent disruption of MEF2-HDAC complexes and nuclear export of HDAC5, and implicate 14-3-3 as a signal-dependent regulator of muscle cell differentiation...
  8. ncbi Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins
    B L Black
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, Dallas 75235 9148, USA
    Annu Rev Cell Dev Biol 14:167-96. 1998
    ..We discuss the diverse functions of this family of transcription factors, the ways in which they are regulated, and their mechanisms of action...
  9. pmc Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2
    Serge Gregoire
    Molecular Oncology Group, Royal Victoria Hospital, McGill University Health Center, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Mol Cell Biol 27:1280-95. 2007
    ..These results reveal an unexpected role for HDAC3 and suggest a novel pathway through which MEF2 activity is controlled in vivo...
  10. ncbi Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C
    Q Lin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235 9148, USA
    Science 276:1404-7. 1997
    ..Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development...
  11. ncbi Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis
    D G Edmondson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Development 120:1251-63. 1994
    ....
  12. ncbi Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins
    J D Molkentin
    Department of Biochemistry and Molecular Biology University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cell 83:1125-36. 1995
    ....
  13. pmc Cocaine regulates MEF2 to control synaptic and behavioral plasticity
    Suprabha Pulipparacharuvil
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9127, USA
    Neuron 59:621-33. 2008
    ....
  14. pmc Beta-catenin interacts with MyoD and regulates its transcription activity
    Chang Hoon Kim
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th St, CB2803, Augusta, GA 30912, USA
    Mol Cell Biol 28:2941-51. 2008
    ..These results demonstrate that beta-catenin is necessary for MyoD function, identifying MyoD as an effector in the Wnt canonical pathway...
  15. pmc HDAC4 deacetylase associates with and represses the MEF2 transcription factor
    E A Miska
    Wellcome CRC Institute, Department of Pathology, Cambridge, UK
    EMBO J 18:5099-107. 1999
    ..These results identify MEF2A as a nuclear target for HDAC4-mediated repression and suggests that compartmentalization may be a novel mechanism for controlling the nuclear activity of this new family of deacetylases...
  16. pmc A p38 MAPK-MEF2C pathway regulates B-cell proliferation
    Dustin Khiem
    Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158 2517, USA
    Proc Natl Acad Sci U S A 105:17067-72. 2008
    ..p38 directly phosphorylates MEF2C via three residues in the C-terminal transactivation domain, establishing MEF2C as a direct transcriptional effector of BCR signaling via p38 MAPK...
  17. ncbi Neuronal activity-dependent cell survival mediated by transcription factor MEF2
    Z Mao
    Division of Neuroscience, Department of Neurology, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 286:785-90. 1999
    ....
  18. ncbi Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
    Lina Kassar-Duchossoy
    Stem Cells and Development, Department of Developmental Biology, CNRS URA 2578, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 431:466-71. 2004
    ..We revise the epistatic relationship of the MRFs, in which both Myf5 and Mrf4 act upstream of Myod to direct embryonic multipotent cells into the myogenic lineage...
  19. ncbi Drosophila MEF2, a transcription factor that is essential for myogenesis
    B A Bour
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802, USA
    Genes Dev 9:730-41. 1995
    ..These results indicate that MEF2 is required for later aspects of differentiation of the three major types of musculature, which include body wall muscles, gut musculature, and the heart, in the Drosophila embryo...
  20. ncbi Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila
    B Lilly
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Science 267:688-93. 1995
    ..These results demonstrate that different muscle cell types share a common myogenic differentiation program controlled by MEF2...
  21. ncbi SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes
    Rebecca Berdeaux
    Peptide Biology Laboratories, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nat Med 13:597-603. 2007
    ....
  22. pmc Cooperation between myogenic regulatory factors and SIX family transcription factors is important for myoblast differentiation
    Yubing Liu
    Ottawa Institute of Systems Biology and Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
    Nucleic Acids Res 38:6857-71. 2010
    ..On the basis of a bioinformatic analysis of gene regulatory sequences, we hypothesized that myogenic regulatory factors (MRFs), key regulators of skeletal myogenesis, cooperate with members of the SIX family of ..
  23. pmc A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation
    Bennett H Penn
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 18:2348-53. 2004
    ....
  24. ncbi MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    Michael A Arnold
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 12:377-89. 2007
    ..These findings reveal unexpected commonalities in the mechanisms governing muscle, cardiovascular, and bone development with respect to their regulation by MEF2 and class II HDACs...
  25. pmc Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C
    Ashraf Said Al Madhoun
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    EMBO J 30:2477-89. 2011
    ..This work identifies the first kinase that regulates MyoD and Myf5 expression in ES or satellite cells...
  26. ncbi Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development
    Evdokia Dodou
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Development 131:3931-42. 2004
    ....
  27. ncbi Control of muscle development by dueling HATs and HDACs
    T A McKinsey
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, Texas 75390 9148, USA
    Curr Opin Genet Dev 11:497-504. 2001
    ..We describe the molecules and mechanisms involved in chromatin remodeling during skeletal muscle development...
  28. ncbi Replicative aging down-regulates the myogenic regulatory factors in human myoblasts
    Anne Bigot
    INSERM, Université Pierre and Marie Curie Paris 6, UMR S 787, Institut de Myologie, Paris 75013, France
    Biol Cell 100:189-99. 2008
    ..The aim of the present study was to determine the effects of replicative senescence on the myogenic programme of human myoblasts...
  29. ncbi Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo
    Raphaelle Grifone
    département génétique et développement, Institut Cochin Paris, INSERM, U567, Paris, F 75014 France
    Dev Biol 302:602-16. 2007
    ..These results establish a new hierarchy of genes controlling early steps of hypaxial myogenic commitment in the mouse embryo...
  30. pmc Caspase-dependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis
    Gabriela Paroni
    Dipartimento di Scienze e Tecnologie Biomediche, Sezione di Biologia Universita di Udine, 33100 Udine, Italy
    Mol Biol Cell 15:2804-18. 2004
    ..Together, our data indicate that caspases could specifically modulate gene repression and apoptosis through the proteolyic processing of HDAC4...
  31. pmc MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function
    Ana C Barbosa
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 105:9391-6. 2008
    ..We conclude that MEF2C limits excessive synapse formation during activity-dependent refinement of synaptic connectivity and thus facilitates hippocampal-dependent learning and memory...
  32. ncbi The conserved transcription factor Mef2 has multiple roles in adult Drosophila musculature formation
    Cédric Soler
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK
    Development 139:1270-5. 2012
    ..These results therefore establish the importance of Mef2 in multiple roles in examples of myogenesis that have parallels in vertebrates and are distinct from that occurring in Drosophila embryogenesis...
  33. ncbi SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice
    Satoru Sasagawa
    Department of Bone and Cartilage Biology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Development 139:1153-63. 2012
    ..These results demonstrate an essential role for SIK3 in facilitating chondrocyte hypertrophy during skeletogenesis and growth plate maintenance...
  34. pmc Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c
    Matthew J Potthoff
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Mol Cell Biol 27:8143-51. 2007
    ..These results reveal a key role for Mef2c in maintenance of sarcomere integrity and postnatal maturation of skeletal muscle...
  35. ncbi Nkx2-5 activity is essential for cardiomyogenesis
    M Jamali
    Department of Biochemistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Biol Chem 276:42252-8. 2001
    ..Therefore, Nkx2-5 function is essential for commitment of mesoderm into the cardiac muscle lineage, and the N-terminal region, together with the homeodomain, is sufficient for cardiomyogenesis in P19 cells...
  36. pmc Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation
    Peter R Wilker
    Department of Pathology and Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Immunol 9:603-12. 2008
    ..Mef2c-dependent targets included the genes encoding cyclin D2 and the prosurvival factor Bcl-x(L). Our results emphasize an unrecognized but critical function for Mef2c in BCR signaling...
  37. ncbi The expression of MEF2 genes is implicated in CNS neuronal differentiation
    X Lin
    Department of Pharmacology, University of Maryland School of Medicine, Baltimore 21201, USA
    Brain Res Mol Brain Res 42:307-16. 1996
    ..These observations suggest that MEF2 molecules may be an important factor involved in CNS neuron differentiation similar to their role in muscle differentiation...
  38. pmc Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95
    Nien Pei Tsai
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 151:1581-94. 2012
    ..Together, our findings reveal roles for multiple autism-linked genes in activity-dependent synapse elimination...
  39. ncbi A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells
    Stephanie Protze
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, 01307 Dresden, Germany
    J Mol Cell Cardiol 53:323-32. 2012
    ..Furthermore, our results point to the importance of verifying multiple lineage specific genes when assessing reprogramming...
  40. pmc Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5
    Jenny X Chen
    Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, USA
    Circ Res 111:50-5. 2012
    ..Direct reprogramming of fibroblasts into cardiomyocytes is a novel strategy for cardiac regeneration. However, the key determinants involved in this process are unknown...
  41. ncbi miR-223 suppresses differentiation of tumor-induced CD11b⁺ Gr1⁺ myeloid-derived suppressor cells from bone marrow cells
    Qiaofei Liu
    Key Laboratory of Bioactive Materials, Department of Immunology, Ministry of Education, Nankai University School of Medicine, Nankai University, Tianjin, China
    Int J Cancer 129:2662-73. 2011
    ....
  42. ncbi The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development
    D Z Wang
    Department of Molecular Biology, Department of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Development 128:4623-33. 2001
    ..Our findings reveal the existence of a regulatory circuit between these two classes of transcription factors that induces, amplifies and maintains their expression during skeletal muscle development...
  43. pmc Transcription factor MEF2A mutations in patients with coronary artery disease
    M R Krishna Bhagavatula
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Mol Genet 13:3181-8. 2004
    ..93%) may carry mutations in MEF2A, although further definition of the prevalence of MEF2A mutations is warranted...
  44. ncbi Defining the regulatory networks for muscle development
    J D Molkentin
    Hamon Center for Basic Research in Cancer, University of Texas, Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, 75235 9148, USA
    Curr Opin Genet Dev 6:445-53. 1996
    ..Elucidation of these aspects of the myogenic program is leading to a detailed understanding of the regulatory circuits controlling muscle development...
  45. pmc Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis
    Christos Gekas
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Blood 113:3461-71. 2009
    ..In summary, this work identifies Mef2C as an integral member of hematopoietic transcription factors with distinct upstream regulatory mechanisms and functional requirements in megakaryocyte and B-lymphoid lineages...
  46. pmc p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps
    Z Wu
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, La Jolla, California 92093 0322, USA
    Mol Cell Biol 20:3951-64. 2000
    ..Importantly, activation of ERK is inhibitory toward myogenic transcription in myoblasts but contributes to the activation of myogenic transcription and regulates postmitotic responses (i.e., hypertrophic growth) in myotubes...
  47. pmc Pax3 induces differentiation of juvenile skeletal muscle stem cells without transcriptional upregulation of canonical myogenic regulatory factors
    Arthur P Young
    Section on Developmental and Stem Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02115, USA
    J Cell Sci 123:2632-9. 2010
    ..Although Pax3 controls embryonic myogenesis through regulation of the canonical myogenic regulatory factors (MRFs) Myf-5, MyoD, myogenin and Mrf4, we find that in postnatal muscle stem cells, ectopic Pax3 ..
  48. pmc Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases
    J Lu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75235 9148, USA
    Proc Natl Acad Sci U S A 97:4070-5. 2000
    ....
  49. ncbi CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses
    Tong Zhang
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0636, USA
    J Biol Chem 282:35078-87. 2007
    ....
  50. ncbi Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4
    H D Youn
    Center for Cancer Research, Department of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Biol Chem 275:22563-7. 2000
    ..Together, HDAC4, MITR, and Cabin1 constitute a family of calcium-sensitive transcriptional repressors of MEF2...
  51. ncbi A role for the myogenic determination gene Myf5 in adult regenerative myogenesis
    Barbara Gayraud-Morel
    Stem Cells and Development, Dept of Developmental Biology, Pasteur Institute, CNRS URA 2578, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Biol 312:13-28. 2007
    ..Therefore, we show that Myf5 is a regulator of regenerative myogenesis and homeostasis, with functions distinct from those of Myod and Mrf4...
  52. pmc Protein kinase A represses skeletal myogenesis by targeting myocyte enhancer factor 2D
    Min Du
    Department of Biology, York University, 4700 Keele Street, Toronto M3J 1P3, Ontario, Canada
    Mol Cell Biol 28:2952-70. 2008
    ..Previously, an indirect modulation of the myogenic regulatory factors (MRFs) was implicated as the mechanism...
  53. ncbi Myostatin regulates fiber-type composition of skeletal muscle by regulating MEF2 and MyoD gene expression
    Alex Hennebry
    AgResearch, Functional Muscle Genomics, Hamilton, New Zealand
    Am J Physiol Cell Physiol 296:C525-34. 2009
    ..We propose that Mstn could regulate fiber-type composition by regulating the expression of MEF2C and MyoD during myogenesis...
  54. pmc MASTR directs MyoD-dependent satellite cell differentiation during skeletal muscle regeneration
    Mayssa H Mokalled
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    Genes Dev 26:190-202. 2012
    ..Our results provide new insights into the genetic circuitry of muscle regeneration and identify MASTR as a central regulator of this process...
  55. ncbi Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation
    G E Lyons
    Department of Anatomy, University of Wisconsin Medical School, Madison 53706, USA
    J Neurosci 15:5727-38. 1995
    ..Since the molecular mechanisms that regulate neuron differentiation are unknown, we propose that the MEF2 factors are likely to play an important role in this process...
  56. ncbi HDAC activity regulates entry of mesoderm cells into the cardiac muscle lineage
    Christina Karamboulas
    Department of Biochemistry, Medical Sciences Building, University of Western Ontario, London, Ontario, N6A 5C1, Canada
    J Cell Sci 119:4305-14. 2006
    ..Our results suggest that HDAC activity regulates the specification of mesoderm cells into cardiomyoblasts by inhibiting the expression of GATA4 and Nkx2-5 in a stem cell model system...
  57. ncbi Alpha-actinin 4 potentiates myocyte enhancer factor-2 transcription activity by antagonizing histone deacetylase 7
    Sharmistha Chakraborty
    Department of Biochemistry, School of Medicine, Case Western Reserve University, and the Research Institute of University Hospitals of Cleveland, OH 44106, USA
    J Biol Chem 281:35070-80. 2006
    ..MEF2A association and enhancement of MEF2-mediated transcription. Taken together, we have identified a novel mechanism by which HDAC7 activity is negatively regulated and uncovered a previously unknown function of alpha-actinin 4...
  58. pmc Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes
    Jeffrey S Martini
    George Zallie and Family Laboratory for Cardiovascular Gene Therapy, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 105:12457-62. 2008
    ..Moreover, significant HDAC activity can be found with GRK5 in the heart. Our data show that GRK5 is a nuclear HDAC kinase that plays a key role in maladaptive cardiac hypertrophy apparently independent of any action directly on GPCRs...
  59. ncbi Human SRF-related proteins: DNA-binding properties and potential regulatory targets
    R Pollock
    Transcription Laboratory, Imperial Cancer Research Fund Laboratories, London, UK
    Genes Dev 5:2327-41. 1991
    ..We discuss the potential role of RSRF proteins in the regulation of these genes...
  60. pmc Antiapoptotic role of the p38 mitogen-activated protein kinase-myocyte enhancer factor 2 transcription factor pathway during neuronal differentiation
    S Okamoto
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:7561-6. 2000
    ..These findings suggest that the p38alpha/MEF2 pathway prevents cell death during neuronal differentiation...
  61. pmc The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis
    Huangxuan Shen
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 20:675-88. 2006
    ..Mechanistically, MAML1 appears to mediate cross-talk between Notch and MEF2 to influence myogenic differentiation...
  62. pmc Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers
    Y Liu
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Cell Biol 155:27-39. 2001
    ..1-s trains at 50 Hz every 50 s. The stimulation pattern-dependent nuclear translocation of NFATc demonstrated here could thus contribute to fast-twitch to slow-twitch fiber type transformation...
  63. pmc mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish
    Craig T Miller
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Dev Biol 308:144-57. 2007
    ..Together our results support a model in which CNC cells require mef2ca downstream of edn1 signaling for proper craniofacial development...
  64. ncbi Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology
    J Han
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA
    Trends Cardiovasc Med 10:19-22. 2000
    ..This review weighs the accumulating evidence for a p38 MAPK-MEF2 signal transduction cascade and discusses its role in cardiac myocyte biology...
  65. pmc Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic, cranial and fin muscle fibre populations
    Yaniv Hinits
    Randall Division for Cell and Molecular Biophysics and MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Campus, King s College London, SE1 1UL, UK
    Development 136:403-14. 2009
    b>Myogenic regulatory factors of the Myod family (MRFs) are transcription factors essential for mammalian skeletal myogenesis...
  66. ncbi pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation
    B G Novitch
    Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School 240 Longwood Avenue, Boston, Massachusetts, 02115, USA
    Curr Biol 9:449-59. 1999
    ....
  67. pmc Regulation of histone deacetylase 4 by binding of 14-3-3 proteins
    A H Wang
    Molecular Oncology Group, Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada
    Mol Cell Biol 20:6904-12. 2000
    ..These results indicate that 14-3-3 proteins negatively regulate HDAC4 by preventing its nuclear localization and thereby uncover a novel regulatory mechanism for HDACs...
  68. ncbi Association and functional analyses of MEF2A as a susceptibility gene for premature myocardial infarction and coronary artery disease
    Ilaria Guella
    Department of Biology and Genetics for Medical Sciences, University of Milan, via Viotti 3 5, Milan, Italy
    Circ Cardiovasc Genet 2:165-72. 2009
    ..However, the association of MEF2A with coronary artery disease/MI was not confirmed in other studies. We analyzed the role of MEF2A in the pathogenesis of MI in 2008 Italian patients with premature MI and in 2008 controls...
  69. ncbi Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells
    Gillian H Little
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 282:7219-31. 2007
    ..These findings identify HDAC4 as a specific downstream substrate of CaMKIIdeltaB in cardiac cells and have broad applications for the signaling pathways leading to cardiac hypertrophy and heart failure...
  70. ncbi Dietary lipid levels have a remarkable impact on the expression of growth-related genes in Senegalese sole (Solea senegalensis Kaup)
    C Campos
    Faculty of Biosciences and Aquaculture, Bodø University College, NO 8049 Bodø, Norway
    J Exp Biol 213:200-9. 2010
    ..In addition to its practical implications, this work provides a valuable contribution towards our understanding of the genetic networks controlling growth in teleosts...
  71. ncbi Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development
    Jun K Takeuchi
    Cardiovascular Research, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada
    Development 132:2463-74. 2005
    ..We conclude that Tbx20 is positioned at a critical node in transcription factor networks required for heart and motoneuron development where it dose-dependently regulates gene expression...
  72. ncbi Mighty is a novel promyogenic factor in skeletal myogenesis
    Amy Marshall
    Functional Muscle Genomics, AgResearch, Hamilton, New Zealand
    Exp Cell Res 314:1013-29. 2008
    ..Given its role in myogenesis, we propose that Mighty is a critical promyogenic factor which plays a key role in the signalling pathway downstream of Myostatin...
  73. ncbi Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors
    Y T Yu
    Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts
    Genes Dev 6:1783-98. 1992
    ..Moreover, MEF2 is induced in nonmuscle cells by MyoD; however, MEF2 alone is insufficient to produce the full muscle phenotype. Implications for the molecular mechanisms of myogenesis are considered...
  74. ncbi Embryonic myogenesis pathways in muscle regeneration
    Po Zhao
    Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Dev Dyn 229:380-92. 2004
    Embryonic myogenesis involves the staged induction of myogenic regulatory factors and positional cues that dictate cell determination, proliferation, and differentiation into adult muscle...
  75. pmc Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A
    John B Knight
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P O Box 26901, Room 853 BMSB, Oklahoma City, OK 73190, USA
    Proc Natl Acad Sci U S A 100:14725-30. 2003
    ..Finally, GEF and MEF2A coimmunoprecipitated in vivo, strongly supporting a mechanism of GLUT4 transcription activation that depends on this protein-protein interaction...
  76. ncbi Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number
    Steven W Flavell
    Neurobiology Program, Children s Hospital, and Departments of Neurology and Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 311:1008-12. 2006
    ..These findings define an activity-dependent transcriptional program that may control synapse number during development...
  77. ncbi A series of mutations in the D-MEF2 transcription factor reveal multiple functions in larval and adult myogenesis in Drosophila
    G Ranganayakulu
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 171:169-81. 1995
    ..These results demonstrate that the D-mef2 gene has multiple functions in myogenesis and tissue morphogenesis during Drosophila development...
  78. ncbi Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatory factors
    Paula F Martinez
    Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University, UNESP Universidad Estadual Paulista, Sao Paulo, Brazil
    Med Sci Monit 16:BR374-83. 2010
    ..In this study we evaluated the expression of myogenic regulatory factors (MRF), myosin heavy chain (MyHC) isoforms, and fiber trophism in the soleus muscle of rats with ..
  79. pmc Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting
    Angie M Y Shum
    Inflammation and Infection Research Centre, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia
    Aging (Albany NY) 4:133-43. 2012
    ..Together, these effects may limit sarcomeric contractile ability and also predispose skeletal muscle to structural instability; associated with muscle wasting and fatigue in cachexia...
  80. pmc A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing
    J F Martin
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Mol Cell Biol 14:1647-56. 1994
    ..The complexity of the MEF2 family of regulatory proteins provides the potential for fine-tuning of transcriptional responses as a consequence of combinatorial interactions among multiple MEF2 isoforms encoded by the four Mef2 genes...
  81. pmc Two cell lineages, myf5 and myf5-independent, participate in mouse skeletal myogenesis
    Malay Haldar
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA Howard Hughes Medical Institute, University of Utah, Salt Lake City, UT 84112, USA
    Dev Cell 14:437-45. 2008
    In skeletal muscle development, the myogenic regulatory factors myf5 and myoD play redundant roles in the specification and maintenance of myoblasts, whereas myf6 has a downstream role in differentiating myocytes and myofibers...
  82. ncbi MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium
    S M Kolodziejczyk
    Ottawa Hospital Research Institute, Ottawa Hospital General Campus, Centre for Molecular Medicine, Ottawa, Ontario, Canada K1H 8L6
    Curr Biol 9:1203-6. 1999
    ..These results provide the first evidence for a single pathway regulating both normal and pathologic cardiomyocyte hypertrophy...
  83. ncbi SOX15 and SOX7 differentially regulate the myogenic program in P19 cells
    Josee Savage
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    Stem Cells 27:1231-43. 2009
    ..Taken together, these results show that both Sox7 and Sox15 are able to induce the early stages of myogenesis, but only Sox7 is sufficient to initiate the formation of fully differentiated skeletal myocytes...
  84. ncbi A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation
    Aryaman Shalizi
    Department of Pathology, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Science 311:1012-7. 2006
    ..Our findings define a mechanism underlying postsynaptic differentiation that may modulate activity-dependent synapse development and plasticity in the brain...
  85. ncbi Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice
    Jian Xu
    Departments of Pharmacology and Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Biol Chem 281:9152-62. 2006
    ....
  86. ncbi 6-Hydroxydopamine-induced PC12 cell death is mediated by MEF2D down-regulation
    Min Kyoung Kim
    Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University, Jeju, South Korea
    Neurochem Res 36:223-31. 2011
    ..These results suggest that PC12 cell death by 6-OHDA appears to be regulated by the down-regulation of MEF2D via some interaction between cdk5 and MAP kinase...
  87. ncbi Cell-specific activation of the atrial natriuretic factor promoter by PITX2 and MEF2A
    Rafael Toro
    Genetics Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 279:52087-94. 2004
    ..These results demonstrate a promoter- and cell-specific functional interaction between PITX2 and MEF2A and suggest the possibility of coordinate control by these factors in the oral epithelium...
  88. ncbi Nampt/visfatin/PBEF affects expression of myogenic regulatory factors and is regulated by interleukin-6 in chicken skeletal muscle cells
    Susan M Krzysik-Walker
    Department of Poultry Science, The Pennsylvania State University, University Park, PA 16802, USA
    Comp Biochem Physiol A Mol Integr Physiol 159:413-21. 2011
    ..mL(-1)) decreased Nampt mRNA abundance. Collectively, these results demonstrate that Nampt, regulated in part by IL-6, alters the expression of key myogenic transcription factors and thereby may influence postnatal myogenesis...
  89. pmc Activity-dependent and -independent nuclear fluxes of HDAC4 mediated by different kinases in adult skeletal muscle
    Yewei Liu
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Cell Biol 168:887-97. 2005
    ....
  90. ncbi Drosophila mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modules
    H T Nguyen
    Department of Medicine, Division of Cardiology, Forchheimer G42, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA
    Dev Biol 204:550-66. 1998
    ....
  91. ncbi Impact of treadmill locomotor training on skeletal muscle IGF1 and myogenic regulatory factors in spinal cord injured rats
    Min Liu
    Department of Physical Therapy, University of Florida, P O Box 100154, Rm 1142 PHHP Bldg, Gainesville, FL 32610, USA
    Eur J Appl Physiol 109:709-20. 2010
    ..of treadmill locomotor training on the expression of insulin-like growth factor I (IGF1) and changes in myogenic regulatory factors (MRFs) in rat soleus muscle following spinal cord injury (SCI)...
  92. ncbi Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5
    Kohei Inagawa
    Department of Clinical and Molecular Cardiovascular Research, Department of Cardiology, Keio University School of Medicine, Tokyo, Japan
    Circ Res 111:1147-56. 2012
    ..We recently found that a combination of 3 cardiac transcription factors, Gata4, Mef2c, and Tbx5 (GMT), reprograms fibroblasts directly into functional cardiomyocytes in vitro...
  93. pmc A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression
    Christina Pagiatakis
    Department of Biology, York University, Toronto M3J 1P3, Canada
    J Biol Chem 287:8361-70. 2012
    ..These data constitute evidence of a novel signaling cascade that links RhoA-mediated calcium sensitivity to MEF2-dependent myocardin expression in VSMCs through a mechanism involving p38 MAPK, PP1α, and CPI-17...
  94. pmc Gli2 and MEF2C activate each other's expression and function synergistically during cardiomyogenesis in vitro
    Anastassia Voronova
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada
    Nucleic Acids Res 40:3329-47. 2012
    ..This model links Shh signalling to MEF2C function during cardiomyogenesis and offers mechanistic insight into their in vivo functions...
  95. ncbi Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts
    Hiroshi Takemori
    Laboratory of Cell Signaling and Metabolism, National Institute of Biomedical Innovation, Osaka, Japan
    Endocr J 56:121-30. 2009
    ..These observations suggest that GSK-3 beta and SIK1 may play important roles in the regulation of PGC-1alpha gene expression by inactivating HDAC5 followed by activation of MEF2C...
  96. ncbi Gene expression of myogenic regulatory factors, nicotinic acetylcholine receptor subunits, and GAP-43 in skeletal muscle following denervation in a rat model
    Jianjun Ma
    Department of Orthopaedic Surgery, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Orthop Res 25:1498-505. 2007
    ..b>Myogenic Regulatory Factors (MRF's) including myoblast determination factor (MyoD), MRF-4, Myogenin, and myogenic factors-5 (myf-5),..
  97. ncbi Spatio-temporal expression of MRF4 transcripts and protein during Xenopus laevis embryogenesis
    Bruno Della Gaspera
    UMR 7060 CNRS, Equipe Biologie du Développement et de la Différenciation Neuromusculaire, Centre Universitaire des Saints Peres, Universite Rene Descartes, Paris, France
    Dev Dyn 235:524-9. 2006
    ..Whole-mount embryo immunohistochemistry revealed that XMRF4 protein accumulated in somite nuclei slightly after XMRF4 transcripts...
  98. pmc Lack of MEF2A mutations in coronary artery disease
    Li Weng
    US Department of Energy, Joint Genome Institute, Walnut Creek, California, USA
    J Clin Invest 115:1016-20. 2005
    ..These studies support that MEF2A mutations are not a common cause of CAD in white people and argue strongly against a role for the MEF2A 21-bp deletion in autosomal dominant CAD...
  99. ncbi A study of the role of the Myocyte-specific Enhancer Factor-2A gene in coronary artery disease
    Samar Elhawari
    Genetics Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Atherosclerosis 209:152-4. 2010
    ..22(0.9-1.54); p=0.088]. Importantly, a haplotype 1A-2G-3G-4A-5C-6G-7G-8A constructed from the studied SNPs was also associated with CAD [6.39(0.93-43.75); p=0.0052]. These results identify MEF2A gene as a susceptibility gene for CAD...
  100. pmc An initial blueprint for myogenic differentiation
    Alexandre Blais
    Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 19:553-69. 2005
    ..We identified a cadre of overlapping and distinct targets of the key myogenic regulatory factors (MRFs)--MyoD and myogenin--and Myocyte Enhancer Factor 2 (MEF2)...
  101. ncbi Expression and subcellular localization of myogenic regulatory factors during the differentiation of skeletal muscle C2C12 myoblasts
    Paola Ferri
    Dipartimento di Scienze dell Uomo, dell Ambiente e della Natura, University of Urbino Carlo Bo, I 61029 Urbino, Italy
    J Cell Biochem 108:1302-17. 2009
    ....

Research Grants39

  1. MOLECULAR BASIS OF MYOGENIC RESPONSE IN DEVELOPMENT
    M Siddiqui; Fiscal Year: 2003
    ..in understanding of the skeletal myogenic regulation was brought by the discovery of the activator myogenic regulatory factors (MRFs), MyoD, myf-5, myogenin, MRF-4, it is now becoming clear that other mechanisms, wherein the ..
  2. Functional Conservation of Myogenic Regulatory Factors
    Thomas H Meedel; Fiscal Year: 2010
    ..Thus, understanding the specific functions of MRF genes has clear relevance for human health. ..
  3. MECHANISMS OF MYOGENIC INDUCTION AND PATTERN IN SOMITES
    Frank Stockdale; Fiscal Year: 1999
    ..Myogenesis is assessed by expression of fast and slow isoforms of myosin heavy chains and expression of myogenic regulatory factors. We report data showing that the neural tube and the notochord independently induce myogenesis in ..
  4. MOLECULAR MECHANISM IN TYPE III GLYCOGEN STORAGE DISEASE
    Yuan Tsong Chen; Fiscal Year: 2002
    ..the promoters and regulatory region of the debranching enzyme gene and to investigate whether myogenic regulatory factors are involved in the expression of muscle-specific debrancher isoforms...
  5. TRANSCRIPTIONAL CONTROL OF CARDIAC MUSCLE DEVELOPMENT
    Eric Olson; Fiscal Year: 2009
    ..Members of the myocyte enhancer factor-2 (MEF2) family of transcription factors are the only known myogenic regulatory factors required for myogenesis and morphogenesis of all muscle cell types...
  6. MOLECULAR AND DEVELOPMENTAL GENETICS OF DROSOPHILA
    William Gelbart; Fiscal Year: 1993
    ..focusing on the nau gene that encodes basic and helix-loop-lelix domains similar to those of vertebrate myogenic regulatory factors. (e) Study the in vitro properties and in vivo function of the products of two genes, ned and nod, ..
  7. Satellite Cells and Skeletal Muscle Growth Dynamics
    Zipora Yablonka Reuveni; Fiscal Year: 2008
    ..The proposed investigation will contribute to a better understanding of satellite cell dynamics and muscle growth, and can prove important for muscle rehabilitation strategies during disease and aging. ..
  8. Molecular Mechanisms of Anthrax-Induced Macrophage Death
    Jiahuai Han; Fiscal Year: 2007
    ..The information obtained in this study will be very valuable in developing new strategies for the treatment of anthrax infection. [unreadable] [unreadable]..
  9. Macrophage Death and Sepsis
    Jiahuai Han; Fiscal Year: 2006
    ..Our study will also lead to a better understanding of how macrophage apoptosis is controlled, which is needed to develop therapeutically useful strategies to selectively promote or inhibit macrophage death. ..
  10. MYOD AND MYOGENIN IN MUSCLE HYPERTROPHY AND SARCOPENIA
    STEPHEN ALWAY; Fiscal Year: 2001
    ....
  11. Id2 REGULATION OF MUSCLE HYPERTROPHY IN AGING
    STEPHEN ALWAY; Fiscal Year: 2007
    ..abstract_text> ..
  12. GENES FOR VASCULAR MORPHOGENESIS: A GENETIC APPROACH
    Qing Wang; Fiscal Year: 2003
    ..Moreover, understanding the genetic mechanisms underlying KTS offers possibilities for treatment of KTS as well as conditions such as cancer that depend on angiogenesis. ..
  13. Molecular Determinants of Coronary Artery Disease
    Qing Wang; Fiscal Year: 2004
    ..The accomplishment of research objectives in this proposal has the potential to have a substantial impact on the understanding of the molecular mechanism of CAD and MI, thereby facilitating better prevention, diagnosis and therapy. ..
  14. Molecular Mechanisms of Cardiac Arrhythmias
    Qing Wang; Fiscal Year: 2005
    ..These studies may provide a new framework for the rational design of therapeutic agents. ..
  15. CELL FATE DETERMINATION IN THE MESODERM OF DROSOPHILA
    Mary Baylies; Fiscal Year: 2008
    ..Our work in Drosophila on the mechanisms and targets of these regulators' action will provide insight as to the underlying causes of these diseases and will help to reveal potential therapies. ..
  16. The effects of allelic variation in Pparg on skeletal metabolism
    Cheryl Ackert Bicknell; Fiscal Year: 2007
    ..This research will determine if Rosiglitazone affects bone and under what circumstances. [unreadable] [unreadable] [unreadable]..
  17. Activity Dependent Signaling in Muscle Fiber Plasticity
    Martin Schneider; Fiscal Year: 2007
    ..The studies proposed here should have important bearing on the effects of use and disuse on muscle fiber gene expression. [unreadable] [unreadable]..
  18. Validating microRNA Analysis in Human Postmortem Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. Genetic regulation of cell fate in the Drosophila heart
    RICHARD CRIPPS; Fiscal Year: 2009
    ..abstract_text> ..
  20. Control of Cardiac Gene Expression Through Regulated Transcriptional Coactivators
    Eric N Olson; Fiscal Year: 2010
    ..abstract_text> ..
  21. Barx2 in limb muscle and tendon development
    Robyn Meech; Fiscal Year: 2007
    ..abstract_text> ..
  22. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
    ....
  23. Signal Transduction Mechanisms in Suicide Brain
    Yogesh Dwivedi; Fiscal Year: 2008
    ..abstract_text> ..
  24. CONTROL OF CALCIUM RELEASE IN SKELETAL MUSCLE FIBERS
    Martin Schneider; Fiscal Year: 2006
    ..The results of these studies should provide further insight into muscle pathological states and to the overall wellness associated with functioning muscle. ..
  25. Genome Wide Mapping of in-vivo protein: DNA interactions
    SANDRA SHARP; Fiscal Year: 2003
    ....
  26. TRANSCRIPTIONAL CONTROL OF CARDIAC HYPERTROPHY
    Eric Olson; Fiscal Year: 2002
    ..End of Abstract) ..
  27. IMPROVING SURVIVAL OF TRANSPLANTED DOPAMINE NEURONS
    Kim Heidenreich; Fiscal Year: 2004
    ....
  28. Laser Microdissection System
    Eric Olson; Fiscal Year: 2004
    ....
  29. Conference on Muscle: Excitation-Contraction Coupling
    Martin Schneider; Fiscal Year: 2003
    ..The organizing committee and session leaders will strive to achieve appropriate representation of women, minorities and disabled. All facilities are handicapped accessible. ..
  30. Disease and Continuous Myofiber Remodeling in EOM
    Linda McLoon; Fiscal Year: 2004
    ..We have shown that the EOM continue to express cells positive for myogenic regulatory factors, such as myoD. Activated satellite cells are always present in adult EOM...
  31. REGULATORS OF MUSCLE DIFFERENTIATION
    Hanh Nguyen; Fiscal Year: 2004
    ..Some of the principles arising from studies in the muscle system may also be applicable to other developmental systems, and thus will potentially contribute to our understanding of other developmental defects in humans. ..
  32. Local Ca2+ signaling in sympathetic ganglion neurons
    Martin Schneider; Fiscal Year: 2005
    ..Our results will provide new insights regarding local Ca2+ signaling mechanisms that could be compromised in neuronal disease. ..
  33. Serial analysis of transcription factor binding sites
    Robyn Meech; Fiscal Year: 2005
    ..Such information may be particularly useful in the design of specifically targeted promoter sequences for gene therapy vectors. ..
  34. A role for p53/MyoD redundancy in myogenesis?
    SANDRA SHARP; Fiscal Year: 2005
    ..To the extent that MyoD and p53 are redundant, it will be important to consider relevant domains of MyoD for applications in cancer treatment. ..
  35. SPECIFICATION OF FAST AND SLOW MUSCLES IN ZEBRAFISH
    Shao Jun Du; Fiscal Year: 2003
    ..The long-term goal of this study is to elucidate the molecular mechanisms behind determination of muscle-specific cell fate during embryonic development. ..
  36. POSTRECEPTOR DYSREGULATION IN DEPRESSION
    Yogesh Dwivedi; Fiscal Year: 2004
    ..abstract_text> ..
  37. MOLECULAR ANALYSIS OF MYOTONIC DYSTROPHY
    SATYAKAM BHAGWATI; Fiscal Year: 2002
    ..This approach is designed to explore the function of these CTG/CUG repeat binding proteins and their possible role in the pathogenesis of DM. ..
  38. COLLABORATIVE R01
    Rhonda Bassel Duby; Fiscal Year: 2002
    ..In this iterative manner, the investigators expect to gain knowledge that ultimately will foster the development of cell transplantation strategies to promote myocardial repair in human patients afflicted with heart failure. ..
  39. Regulation of Mandibular Condylar Cartialage Growth
    Robert Hinton; Fiscal Year: 2006
    ..If the perichondrial cells in MCC share regulatory features with cells in SUT rather than in SOS, this assumption is not only erroneous but may lead to inappropriate treatment strategies. ..