muscle proteins

Summary

Summary: The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.

Top Publications

  1. ncbi Defective membrane repair in dysferlin-deficient muscular dystrophy
    Dimple Bansal
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Nature 423:168-72. 2003
  2. ncbi Identification of ubiquitin ligases required for skeletal muscle atrophy
    S C Bodine
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
    Science 294:1704-8. 2001
  3. pmc Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 117:399-412. 2004
  4. ncbi FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
    Jinghui Zhao
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 6:472-83. 2007
  5. ncbi Expression of a single transfected cDNA converts fibroblasts to myoblasts
    R L Davis
    Department of Genetics, Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 51:987-1000. 1987
  6. pmc Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
    M D Gomes
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:14440-5. 2001
  7. ncbi The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
    Trevor N Stitt
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Mol Cell 14:395-403. 2004
  8. pmc During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation
    Shenhav Cohen
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 185:1083-95. 2009
  9. ncbi Regulation of contraction in striated muscle
    A M Gordon
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195 7290, USA
    Physiol Rev 80:853-924. 2000
  10. ncbi The molecular basis of muscular dystrophy in the mdx mouse: a point mutation
    P Sicinski
    Medical Research Unit, MRC Centre, Cambridge, United Kingdom
    Science 244:1578-80. 1989

Detail Information

Publications320 found, 100 shown here

  1. ncbi Defective membrane repair in dysferlin-deficient muscular dystrophy
    Dimple Bansal
    Howard Hughes Medical Institute, Department of Physiology and Biophysics, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa 52242, USA
    Nature 423:168-72. 2003
    ..Our findings show that disruption of the muscle membrane repair machinery is responsible for dysferlin-deficient muscle degeneration, and highlight the importance of this basic cellular mechanism of membrane resealing in human disease...
  2. ncbi Identification of ubiquitin ligases required for skeletal muscle atrophy
    S C Bodine
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591 6707, USA
    Science 294:1704-8. 2001
    ..Overexpression of MAFbx in myotubes produced atrophy, whereas mice deficient in either MAFbx or MuRF1 were found to be resistant to atrophy. These proteins are potential drug targets for the treatment of muscle atrophy...
  3. pmc Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
    Marco Sandri
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 117:399-412. 2004
    ..Thus, forkhead factor(s) play a critical role in the development of muscle atrophy, and inhibition of Foxo factors is an attractive approach to combat muscle wasting...
  4. ncbi FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells
    Jinghui Zhao
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 6:472-83. 2007
    ..These studies indicate that decreased IGF-1-PI3K-Akt signaling activates autophagy not only through mTOR but also more slowly by a transcription-dependent mechanism involving FoxO3...
  5. ncbi Expression of a single transfected cDNA converts fibroblasts to myoblasts
    R L Davis
    Department of Genetics, Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 51:987-1000. 1987
    ..The major open reading frame encoded by this cDNA contains a short protein segment similar to a sequence present in the myc protein family...
  6. pmc Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy
    M D Gomes
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:14440-5. 2001
    ..Atrogin-1 is one of the few examples of an F-box protein or Ub-protein ligase (E3) expressed in a tissue-specific manner and appears to be a critical component in the enhanced proteolysis leading to muscle atrophy in diverse diseases...
  7. ncbi The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
    Trevor N Stitt
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Mol Cell 14:395-403. 2004
    ....
  8. pmc During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation
    Shenhav Cohen
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 185:1083-95. 2009
    ..Because these proteins stabilize the thick filament, their selective ubiquitylation may facilitate thick filament disassembly. However, the thin filament components decreased by a mechanism not requiring MuRF1...
  9. ncbi Regulation of contraction in striated muscle
    A M Gordon
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195 7290, USA
    Physiol Rev 80:853-924. 2000
    ..9) Different Tn subunit isoforms can modulate the cross-bridge detachment rate as shown by studies with mutant regulatory proteins in myotubes and in in vitro motility assays. (ABSTRACT TRUNCATED)..
  10. ncbi The molecular basis of muscular dystrophy in the mdx mouse: a point mutation
    P Sicinski
    Medical Research Unit, MRC Centre, Cambridge, United Kingdom
    Science 244:1578-80. 1989
    ..Sequence analysis of the amplification products showed that the mdx mouse has a single base substitution within an exon, which causes premature termination of the polypeptide chain...
  11. ncbi Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling
    Xiaonan Wang
    Renal Division, WMB 338, Emory University School of Medicine, M S 1930 001 1AG, 1639 Pierce Drive, Atlanta, Georgia 30322, USA
    Endocrinology 147:4160-8. 2006
    ..Thus, insulin resistance causes muscle wasting by mechanisms that involve suppression of PI3K/Akt signaling leading to activation of caspase-3 and the ubiquitin-proteasome proteolytic pathway causing muscle protein degradation...
  12. ncbi Protein degradation by the ubiquitin-proteasome pathway in normal and disease states
    Stewart H Lecker
    Nephrology Division, Beth Isreal Deaconess, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 17:1807-19. 2006
  13. ncbi Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells
    D D Cornelison
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 191:270-83. 1997
    ..From the individual satellite cell expression types observed, a model of the satellite cell population at rest and during the time course of activation was generated...
  14. ncbi Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size
    Anne Ulrike Trendelenburg
    Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, Basel, Switzerland
    Am J Physiol Cell Physiol 296:C1258-70. 2009
    ..In vivo, inhibition of myostatin increases muscle creatine kinase activity, coincident with an increase in muscle size, demonstrating that this in vitro differentiation measure is also upregulated in vivo...
  15. ncbi Function and genetics of dystrophin and dystrophin-related proteins in muscle
    Derek J Blake
    Medical Research Council, Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    Physiol Rev 82:291-329. 2002
    ..This review discusses the role of the dystrophin complex and protein family in muscle and describes the physiological processes that are affected in Duchenne muscular dystrophy...
  16. ncbi The multifunctional roles of the four-and-a-half-LIM only protein FHL2
    M Johannessen
    Department of Microbiology and Virology, University of Tromsø, 9037 Tromsø, Norway
    Cell Mol Life Sci 63:268-84. 2006
    ..We describe the transcription regulation, the expression profile, the interaction partners, the subcellular localization, the biological functions and discuss the possible involvement of FHL2 in human diseases...
  17. ncbi Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
    Daniel Cuthbertson
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, Scotland
    FASEB J 19:422-4. 2005
    ..Countermeasures to maximize muscle maintenance should target these deficits...
  18. pmc An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice
    Farah Sheikh
    Department of Medicine, UCSD, La Jolla, California 92093, USA
    J Clin Invest 118:3870-80. 2008
    ..These studies shed light on the physiological regulation of the sarcomere in response to hypertrophic stress...
  19. ncbi The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle
    Brian A Clarke
    Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, USA
    Cell Metab 6:376-85. 2007
    ..These data identify the mechanism by which MYH is depleted under atrophy conditions and demonstrate that inhibition of a single E3 ligase, MuRF1, is sufficient to maintain this important sarcomeric protein...
  20. pmc Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts
    Diana Whitaker-Menezes
    Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1772-83. 2011
    ..Most importantly, our current findings provide a new rationale and novel strategy for anti-cancer therapies, by employing MCT inhibitors...
  21. pmc The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
    K S Dimmer
    Physiologisches Institut der Universitat, Gmelinstr 5, D 72076 Tubingen, Germany
    Biochem J 350:219-27. 2000
    ..Similar to MCT1, monocarboxylate transport via MCT4 was sensitive to inhibition by the thiol reagent p-chloromercuribenzoesulphonic acid...
  22. ncbi IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1
    Jennifer M Sacheck
    Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 287:E591-601. 2004
    ..Thus an important component of growth stimulation by IGF-I, through the PI3K-Akt pathway, is its ability to rapidly suppress transcription of the atrophy-related E3 atrogin-1 and other atrogenes and degradation of myofibrillar proteins...
  23. pmc The initiation factor eIF3-f is a major target for atrogin1/MAFbx function in skeletal muscle atrophy
    Julie Lagirand-Cantaloube
    Laboratoire de Génomique Fonctionnelle et Myogenèse, UMR866 Différenciation Cellulaire et Croissance, INRA UM II, Campus INRA SupAgro, Montpellier, France
    EMBO J 27:1266-76. 2008
    ..We conclude that eIF3-f is a key target that accounts for MAFbx function during muscle atrophy and has a major role in skeletal muscle hypertrophy. Thus, eIF3-f seems to be an attractive therapeutic target...
  24. pmc The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins
    Rosanna Piccirillo
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 31:3334-50. 2012
    ..Thus, p97 restrains post-natal muscle growth, and during atrophy, is essential for the accelerated degradation of most muscle proteins.
  25. ncbi Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression
    Hongmin Chen
    Department of Gynecologic Oncology, Henan Cancer Hospital, Zhengzhou, China
    Clin Exp Metastasis 27:557-69. 2010
    ....
  26. pmc Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis
    Marcus M Seldin
    Department of Physiology and Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 287:11968-80. 2012
    ..Collectively, these results suggest that myonectin links skeletal muscle to lipid homeostasis in liver and adipose tissue in response to alterations in energy state, revealing a novel myonectin-mediated metabolic circuit...
  27. ncbi Prevalence of long-QT syndrome gene variants in sudden infant death syndrome
    Marianne Arnestad
    Institute of Forensic Medicine, University of Oslo, Oslo, Norway
    Circulation 115:361-7. 2007
    ..Given the importance and potential implications of these observations, we performed a study to more accurately quantify the contribution to SIDS of LQTS gene mutations and rare variants...
  28. pmc Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases
    Viviana Moresi
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 143:35-45. 2010
    ..Thus, myogenin plays a dual role as both a regulator of muscle development and an inducer of neurogenic atrophy. These findings reveal a specific pathway for muscle wasting and potential therapeutic targets for this disorder...
  29. ncbi Trefoil factors: initiators of mucosal healing
    Douglas Taupin
    The Canberra Hospital, Canberra, Australian Capital Territory, Australia
    Nat Rev Mol Cell Biol 4:721-32. 2003
    ..TFFs protect mucous epithelia from a range of insults and contribute to mucosal repair, although the signalling events that mediate these responses are only partially understood...
  30. ncbi Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD
    S Tajbakhsh
    Department of Molecular Biology, Centre National de la Recherche Scientifique, Unité de Recherche Associe 1947, Pasteur Institute, Paris, France
    Cell 89:127-38. 1997
    ..Therefore, Pax-3 and Myf-5 define two distinct myogenic pathways, and MyoD acts genetically downstream of these genes for myogenesis in the body. This genetic hierarchy does not appear to operate for head muscle formation...
  31. ncbi Baf60c is essential for function of BAF chromatin remodelling complexes in heart development
    Heiko Lickert
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Nature 432:107-12. 2004
    ....
  32. ncbi SCN5A channelopathies--an update on mutations and mechanisms
    Thomas Zimmer
    Institute of Physiology II, Friedrich Schiller University Jena, Kollegiengasse 9, 07743 Jena, Germany
    Prog Biophys Mol Biol 98:120-36. 2008
    ..Possible reasons for less convincing genotype-phenotype correlations are suggested...
  33. ncbi A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
    Christos S Katsanos
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Am J Physiol Endocrinol Metab 291:E381-7. 2006
    ..We conclude that increasing the proportion of leucine in a mixture of EAA can reverse an attenuated response of muscle protein synthesis in elderly but does not result in further stimulation of muscle protein synthesis in young subjects...
  34. ncbi Myofibrillar protein turnover: the proteasome and the calpains
    D E Goll
    Muscle Biology Group, University of Arizona, Tucson, AZ 85721, USA
    J Anim Sci 86:E19-35. 2008
    ..It seems that both the calpains and the proteasome are responsible for myofibrillar protein turnover, but the mechanism is still unknown...
  35. ncbi A gene related to Caenorhabditis elegans spermatogenesis factor fer-1 is mutated in limb-girdle muscular dystrophy type 2B
    R Bashir
    Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Nat Genet 20:37-42. 1998
    ..The proposed name 'dysferlin' combines the role of the gene in producing muscular dystrophy with its C. elegans homology...
  36. ncbi The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    Mohammed S Ullah
    Department of Biochemistry, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, United Kingdom
    J Biol Chem 281:9030-7. 2006
    ..We conclude that MCT4, like other glycolytic enzymes, is up-regulated by hypoxia through a HIF-1alpha-mediated mechanism. This adaptive response allows the increased lactic acid produced during hypoxia to be rapidly lost from the cell...
  37. pmc Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2
    Christian C Witt
    Institute of Anesthesiology and Intensive Care, Universitatsklinikum Mannheim, Mannheim, Germany
    EMBO J 27:350-60. 2008
    ..Thus, combined inhibition of MuRF1/MuRF2 could provide a potent strategy to stimulate striated muscles anabolically and to protect muscles from sarcopenia during ageing...
  38. pmc Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation
    Baron Chanda
    Department of Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Gen Physiol 120:629-45. 2002
    ..These experiments allow us to map structural features onto the kinetic landscape of a sodium channel during activation...
  39. ncbi Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231
    Shannon M Gallagher
    Department of Pathology, Anatomy and Cell Biology and Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 67:4182-9. 2007
    ..These data provide a molecular link between two hallmarks of metastatic cancer: the glycolytic switch and increased expression of CD147...
  40. pmc Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle
    P L Greenhaff
    Centre for Integrated Systems Biology and Medicine, Univ of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Am J Physiol Endocrinol Metab 295:E595-604. 2008
    ..Thus increasing AA and insulin availability causes changes in anabolic signaling and amounts of enzymes of the ubiquitin-proteasome pathway, which cannot be easily reconciled with observed effects on MPS or LPB...
  41. pmc A Foxo/Notch pathway controls myogenic differentiation and fiber type specification
    Tadahiro Kitamura
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:2477-85. 2007
    ..Notch/Foxo1 cooperation may integrate environmental cues through Notch with metabolic cues through Foxo1 to regulate progenitor cell maintenance and differentiation...
  42. ncbi Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men
    Daniel R Moore
    Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Canada
    Am J Clin Nutr 89:161-8. 2009
    ..The anabolic effect of resistance exercise is enhanced by the provision of dietary protein...
  43. pmc Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease
    Monte S Willis
    Division of Cardiology, McAllister Heart Institute, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, NC 27599 7126, USA
    Circ Res 106:463-78. 2010
    ..In summary, the crosstalk between the UPS and autophagy highlight the pivotal and diverse roles the UPS plays in maintaining protein quality control and regulating cardiovascular development and disease...
  44. ncbi Smad2 and 3 transcription factors control muscle mass in adulthood
    Roberta Sartori
    Venetian Institute of Molecular Medicine, 35129 Padova, Italy
    Am J Physiol Cell Physiol 296:C1248-57. 2009
    ..Thus myostatin and Akt pathways cross-talk at different levels. These findings point to myostatin inhibitors as good drugs to promote muscle growth during rehabilitation, especially when they are combined with IGF-1-Akt activators...
  45. pmc Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo
    Monte S Willis
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
    Circ Res 100:456-9. 2007
    ..These studies describe for the first time distinct and nonoverlapping functional characteristics of MuRF1 and MuRF2 in response to cardiac stress in vivo...
  46. pmc Cytoskeletal protein kinases: titin and its relations in mechanosensing
    Mathias Gautel
    King s College London BHF Centre of Research Excellence, Cardiovascular Division, London, SE1 1UL, UK
    Pflugers Arch 462:119-34. 2011
    ..Similar to other MLCK-like kinases like DRAK2 and DAPK1, TK is linked to protein turnover regulation via the autophagy/lysosomal system, suggesting the MLCK-like kinases have common functions beyond contraction regulation...
  47. pmc Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice
    Pradyut K Paul
    Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Cell Biol 191:1395-411. 2010
    ..This study unveils a novel mechanism of skeletal muscle atrophy and suggests that TRAF6 is an important therapeutic target to prevent skeletal muscle wasting...
  48. ncbi Hypertrophy of the heart: a new therapeutic target?
    Norbert Frey
    Department of Cardiology, University of Heidelberg N F, H A K, Heidelberg, Germany
    Circulation 109:1580-9. 2004
    ..We also summarize observations from animal models and clinical trials that suggest benefit from an antihypertrophic strategy...
  49. ncbi Gαi2 signaling promotes skeletal muscle hypertrophy, myoblast differentiation, and muscle regeneration
    Giulia C Minetti
    Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, 4056 Basel, Switzerland
    Sci Signal 4:ra80. 2011
    ....
  50. pmc Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1
    Maimon E Hubbi
    Graduate Training Program in Cellular and Molecular Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 287:6139-49. 2012
    ..These results identify FHL proteins as negative regulators of HIF-1 activity, which may provide a mechanism by which they suppress tumor growth...
  51. ncbi Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling
    Philip J Atherton
    School of Graduate Entry Medicine and Health, Division of Clinical Physiology, University of Nottingham, Royal Derby Hospital, Derby, United Kingdom
    Am J Clin Nutr 92:1080-8. 2010
    ..We previously showed that human muscle protein synthesis (MPS) increased during infusion of amino acids (AAs) and peaked at ≈120 min before returning to baseline rates, despite elevated plasma AA concentrations...
  52. ncbi The underappreciated role of muscle in health and disease
    Robert R Wolfe
    University of Texas Medical Branch, Department of Surgery and Shriners Burns Hospital, Metabolism Unit, Galveston, TX 77550, USA
    Am J Clin Nutr 84:475-82. 2006
    ....
  53. pmc Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein
    Shanon L Casperson
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA
    Clin Nutr 31:512-9. 2012
    ..Protein-energy supplementation is routinely employed to combat muscle loss. However, success is often compromised by increased satiety, poor palatability, high costs and low compliance...
  54. ncbi Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients
    E D Siew
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    Kidney Int 71:146-52. 2007
    ..This study demonstrates that insulin resistance is evident in non-diabetic dialysis patients, is associated with skeletal muscle protein breakdown, and represents a novel target for intervention in uremic wasting...
  55. pmc RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
    Wei Guo
    Muscle Biology Laboratory, University of Wisconsin Madison, USA
    Nat Med 18:766-73. 2012
    ..Our studies emphasize the key role of post-transcriptional regulation in cardiac function and provide mechanistic insights into the pathogenesis of human heart failure...
  56. ncbi Transgelin promotes migration and invasion of cancer stem cells
    Eun Kyung Lee
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    J Proteome Res 9:5108-17. 2010
    ..Taken together, these results indicate that the metastatic potential of CSCs arises from highly expressed Transgelin...
  57. pmc Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy
    Koichi Ojima
    Calpain Project, The Tokyo Metropolitan Institute of Medical Science Rinshoken, Tokyo, Japan
    J Clin Invest 120:2672-83. 2010
    ..Furthermore, our data provide direct evidence that loss of p94 protease activity can result in LGMD2A and molecular insight into how this could occur...
  58. pmc Redox homeostasis, oxidative stress and disuse muscle atrophy
    Maria Antonietta Pellegrino
    Department of Physiology, University of Pavia, Pavia, Italy
    J Physiol 589:2147-60. 2011
    ..A precise approach to determine the levels of ROS in living cells in various conditions appears to be of paramount importance to define and support such hypotheses...
  59. pmc Disruption of SM22 promotes inflammation after artery injury via nuclear factor kappaB activation
    Jianbin Shen
    Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA
    Circ Res 106:1351-62. 2010
    ..Abolishing SM22 in apolipoprotein E knockout mice accelerates atherogenesis. However, it is unclear whether SM22 disruption independently promotes arterial inflammation...
  60. ncbi Monocarboxylate transporter 1 is up-regulated in basal-like breast carcinoma
    Celine Pinheiro
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus of Gualtar, Braga, Portugal
    Histopathology 56:860-7. 2010
    ..However, their role in solid tumours is still poorly understood. Thus, the present work aimed to contribute to understanding the involvement of MCT1 and MCT4 in breast cancer progression as well as MCT regulation by CD147...
  61. pmc Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers
    Agnieszka K Witkiewicz
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:1108-17. 2012
    ....
  62. pmc Kindlin-2 controls bidirectional signaling of integrins
    Eloi Montanez
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Genes Dev 22:1325-30. 2008
    ..Our findings provide evidence that Kindlin-2 is a novel and essential element of bidirectional integrin signaling...
  63. ncbi The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules
    Melanie K Miller
    Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    J Mol Biol 333:951-64. 2003
    ..We speculate that the myofibrillar MARPs are regulated by stretch, and that this links titin-N2A-based myofibrillar stress/strain signals to a MARP-based regulation of muscle gene expression...
  64. ncbi Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing
    Britta Strehl
    Institut fur Biochemie, Charite, Berlin University Berlin, Germany
    Immunol Rev 207:19-30. 2005
    ....
  65. ncbi MyoD or Myf-5 is required for the formation of skeletal muscle
    M A Rudnicki
    Institute for Molecular Biology and Biotechnology, McMaster University, Hamilton, Ontario, Canada
    Cell 75:1351-9. 1993
    ....
  66. pmc Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion
    Elisa I Glover
    Department of Kinesiology Exercise Metabolism Research Group, McMaster University, 1280 Main St West, Hamilton, ON L8S 4K1, Canada
    J Physiol 586:6049-61. 2008
    ..The immobilization-induced decline in post-absorptive MPS with the 'anabolic resistance' to amino acids can account for much of immobilization-induced muscle atrophy...
  67. ncbi Temporal alterations in protein signaling cascades during recovery from muscle atrophy
    Thomas E Childs
    Department of Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA
    Am J Physiol Cell Physiol 285:C391-8. 2003
    ..Thus the time course of increase in molecules of signaling pathways differed as the young rat soleus muscle regrew from an atrophied state...
  68. ncbi Nebulin and N-WASP cooperate to cause IGF-1-induced sarcomeric actin filament formation
    Kazunori Takano
    Department of Biology, Graduate School of Science, Chiba University, 1 33 Yayoicho, Inageku, Chiba 263 8522, Japan
    Science 330:1536-40. 2010
    ..These findings present the mechanisms of IGF-1-induced actin filament formation in myofibrillogenesis required for muscle maturation and hypertrophy and a mechanism of actin nucleation...
  69. ncbi Signaling pathways perturbing muscle mass
    David J Glass
    Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
    Curr Opin Clin Nutr Metab Care 13:225-9. 2010
    ..To discuss the mechanisms of muscle loss during cachexia...
  70. pmc The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line
    D O Fürst
    Max Planck Institute for Biophysical Chemistry, Gottingen, Federal Republic of Germany
    J Cell Biol 106:1563-72. 1988
    ..We discuss the results in relation to titin molecules having half-sarcomere lengths. The three nebulin antibodies so far characterized again give rise to distinct pairs of stripes. These locate close to the N2 line...
  71. ncbi Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome
    Claire Niro
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Dev Biol 338:168-82. 2010
    ..This in vivo wide transcriptomal analysis of the function of the master myogenic determinants, Six, identifies them as novel markers for the differential activation of a specific muscle program during mammalian somitic myogenesis...
  72. pmc Myogenic specification of side population cells in skeletal muscle
    Atsushi Asakura
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, K1H 8L6 Canada
    J Cell Biol 159:123-34. 2002
    ....
  73. ncbi Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction
    Matteo Vatta
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, Texas, USA
    J Am Coll Cardiol 42:2014-27. 2003
    ..We evaluated the role of Cypher/ZASP in the pathogenesis of dilated cardiomyopathy (DCM) with or without isolated non-compaction of the left ventricular myocardium (INLVM)...
  74. pmc Mechanoenzymatics of titin kinase
    Elias M Puchner
    Chair for Applied Physics, Center for Integrated Protein Science Munich and Center for Nanoscience, Ludwig Maximilians Universitat Munchen, 80799 Munich, Germany
    Proc Natl Acad Sci U S A 105:13385-90. 2008
    ..Furthermore, we identify the steps in which the autoinhibition of TK is mechanically relieved at low forces, leading to binding of the cosubstrate ATP and priming the enzyme for subsequent autophosphorylation and substrate turnover...
  75. pmc Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle
    Hans C Dreyer
    Department of Physical Therapy, Division of Rehabilitation Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1144, USA
    Am J Physiol Endocrinol Metab 294:E392-400. 2008
    ..05). Our data suggest that enhanced activation of the mTOR signaling pathway is playing a role in the greater synthesis of muscle proteins when resistance exercise is followed by EAA+CHO ingestion.
  76. ncbi Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing
    Niall J Lennon
    Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 278:50466-73. 2003
    ..We propose a model of muscle membrane healing mediated by dysferlin that is relevant to both normal and dystrophic muscle and defines the annexins as potential muscular dystrophy genes...
  77. pmc The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9
    Amber L Bowman
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 19:3782-92. 2008
    ..Our results suggest that the Rho-GEF domain interacts with RanBP9 and that both can interact with the N-terminal region of titin to influence the formation of the Z-disk and A/I junction...
  78. pmc Hereditary ovarian cancer and two-compartment tumor metabolism: epithelial loss of BRCA1 induces hydrogen peroxide production, driving oxidative stress and NFκB activation in the tumor stroma
    Ubaldo E Martinez-Outschoorn
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 11:4152-66. 2012
    ..Our results suggest that new cancer prevention trials with antioxidants are clearly warranted in patients that harbor hereditary/familial BRCA1 mutations...
  79. ncbi Mighty is a novel promyogenic factor in skeletal myogenesis
    Amy Marshall
    Functional Muscle Genomics, AgResearch, Hamilton, New Zealand
    Exp Cell Res 314:1013-29. 2008
    ..Given its role in myogenesis, we propose that Mighty is a critical promyogenic factor which plays a key role in the signalling pathway downstream of Myostatin...
  80. ncbi Transgelin: an actin-binding protein and tumour suppressor
    Stephen J Assinder
    Discipline of Physiology, School of Medical Sciences and Bosch Institute, University of Sydney, NSW 2006, Australia
    Int J Biochem Cell Biol 41:482-6. 2009
    ..Its expression is lost in prostate, breast and colon cancers. This is consistent with suppression of the metallo matrix protease-9 (MMP-9) by transgelin, where MMP-9 is upregulated in these common cancers...
  81. ncbi Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas
    Celine Pinheiro
    Life and Health Sciences Research Institute, University of Minho, Campus de Gualtar, 4710 057, Braga, Portugal
    Virchows Arch 452:139-46. 2008
    ..The increased expression of these transporters suggests an important role in CRC, which might justify their use, especially MCT1 and MCT4, as targets in CRC drug therapy...
  82. ncbi New aspects of obscurin in human striated muscles
    Lena Carlsson
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, Umea, Sweden
    Histochem Cell Biol 130:91-103. 2008
    ..As myosin was absent in such areas but later reincorporated in the newly formed sarcomeres, our results support that obscurin also might play an important role in the formation and maintenance of A-bands...
  83. ncbi Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin
    E S Moreira
    1 Centro de Estudos do Genoma Humano, Universidade de Sao Paulo, Sao Paulo, Brazil
    Nat Genet 24:163-6. 2000
    ..2 Mb. The gene encoding telethonin, a sarcomeric protein, lies within this candidate region. We have found that mutations in the telethonin gene cause LGMD 2G, identifying a new molecular mechanism for AR LGMD...
  84. pmc The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization
    Elisa Bergamin
    Structural Biology Program, Kimmel Center for Biology and Medicine of the Skirball Institute and Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell 39:100-9. 2010
    ..neuromuscular junction requires, among others proteins, Agrin, a neuronally derived ligand, and the following muscle proteins: LRP4, the receptor for Agrin; MuSK, a receptor tyrosine kinase (RTK); and Dok7 (or Dok-7), a cytoplasmic ..
  85. ncbi Inhibition of atrogin-1/MAFbx expression by adenovirus-delivered small hairpin RNAs attenuates muscle atrophy in fasting mice
    Haolong Cong
    Center for Molecular Virology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Hum Gene Ther 22:313-24. 2011
    ..Taken together, the present study showed that MAFbx could be a potential molecular target for treating muscle atrophy...
  86. ncbi Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C
    Yimingjiang Maiweilidan
    INSERM, UMR S 665, Paris, F 75015, France
    Exp Cell Res 317:724-36. 2011
    ..Here we searched for muscle proteins binding to ankyrin-G OTBD by yeast two hybrid assay, and we found plectin and filamin C, two organizing ..
  87. pmc The FSHD atrophic myotube phenotype is caused by DUX4 expression
    Céline Vanderplanck
    Laboratory of Molecular Biology, University of Mons, Mons, Belgium
    PLoS ONE 6:e26820. 2011
    ..The DUX4 protein initiates a large transcription deregulation cascade leading to muscle atrophy and oxidative stress, which are FSHD key features...
  88. pmc Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover
    Stephan Lange
    School of Medicine, University of California, San Diego, La Jolla, CA 92093 0613, USA
    Mol Biol Cell 23:2490-504. 2012
    ..The interaction of KCTD6 with ankyrin-1 may have implications beyond muscle for hereditary spherocytosis, as KCTD6 is also present in erythrocytes, and erythrocyte ankyrin isoforms contain its mapped minimal binding site...
  89. pmc Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II
    J R Marszalek
    Division of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA
    Proc Natl Acad Sci U S A 96:5043-8. 1999
    ....
  90. pmc Muscle giants: molecular scaffolds in sarcomerogenesis
    Aikaterini Kontrogianni-Konstantopoulos
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Physiol Rev 89:1217-67. 2009
    ....
  91. ncbi The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy
    Victoria C Foletta
    Centre for Physical Activity and Nutrition Research, School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, 3125, Burwood, Australia
    Pflugers Arch 461:325-35. 2011
    ..Finally, we will comment on new approaches that may expand our knowledge of these two molecules in their control of skeletal muscle function...
  92. ncbi Redefining dysferlinopathy phenotypes based on clinical findings and muscle imaging studies
    C Paradas
    Department of Neurology, Hospital de la Santa Creu i Sant Pau, C Pare Claret 167, 08025 Barcelona, Spain
    Neurology 75:316-23. 2010
    ..Our objective was to find clinical or MRI markers to differentiate phenotypes of dysferlin myopathy regardless of initial symptoms...
  93. pmc Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin
    Chuanxi Cai
    Departments of Physiology and Biophysics, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Biol Chem 284:15894-902. 2009
    ....
  94. ncbi Distal anterior compartment myopathy: a dysferlin mutation causing a new muscular dystrophy phenotype
    I Illa
    Department of Neurology, Hospital Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Ann Neurol 49:130-4. 2001
    ..Dysferlin immunostaining was negative. Gene analysis revealed a frameshift mutation in the exon 50 (delG5966) of the DYSF gene. This phenotype further demonstrates the clinical heterogeneity of the dysferlinopathies...
  95. ncbi Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy
    J Liu
    Day Neuromuscular Research Laboratory, Charlestown, Massachusetts 02129, USA
    Nat Genet 20:31-6. 1998
    ..Identical mutations in the dysferlin gene can produce more than one myopathy phenotype (MM, limb girdle dystrophy, distal myopathy with anterior tibial onset)...
  96. pmc Myocyte remodeling in response to hypertrophic stimuli requires nucleocytoplasmic shuttling of muscle LIM protein
    Samuel Y Boateng
    Department of Physiology and Biophysics M C 901, University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, IL 60612 7342, USA
    J Mol Cell Cardiol 47:426-35. 2009
    ..These findings suggest that nucleocytoplasmic shuttling MLP plays an important role in the regulation of the myocyte remodeling and hypertrophy and is required for adaptation to hypertrophic stimuli...
  97. pmc Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis
    Micah J Drummond
    Departments of Physical Therapy, University of Texas Medical Branch, Galveston, 77555 1144, USA
    J Physiol 587:1535-46. 2009
    ....
  98. ncbi AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration
    Yanchao Huang
    Center for Human and Clinical Genetics, Leiden Univesity Medical Center, Leiden, The Netherlands
    FASEB J 21:732-42. 2007
    ..It may also have significant implications for understanding the biology of AHNAK-containing exocytotic vesicles, "enlargosomes," in plasma membrane remodeling and repair...
  99. ncbi Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein
    Véronique Pizon
    European Molecular Biology Laboratory, Cell Biology Division, Heidelberg, Germany
    J Cell Sci 115:4469-82. 2002
    ..A C-terminal isoform is generated by alternative reading frame use, a novelty in muscle proteins. In mature cardiac sarcomeres, endogenous MURF2 can associate with the M-band, and is translocated to the ..
  100. pmc The Nebulin family: an actin support group
    Christopher T Pappas
    Department of Cell Biology, and Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ, USA
    Trends Cell Biol 21:29-37. 2011
    ..In this review, we discuss the current evolutionary, biochemical, and functional data for the nebulin family of proteins - a family whose members, both large and small, function as cytoskeletal scaffolds and stabilizers...
  101. ncbi Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids
    Christos S Katsanos
    Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA
    Am J Clin Nutr 82:1065-73. 2005
    Previous evidence suggests that aging in healthy persons does not result in decreased incorporation of muscle proteins after a bolus ingestion of 15 g essential amino acids (EAAs).

Research Grants68

  1. Amino Acids and Muscle Protein Synthesis
    Robert Wolfe; Fiscal Year: 2006
    ..abstract_text> ..
  2. Effects of Albuterol on Muscle Protein Synthesis
    Charles Lambert; Fiscal Year: 2007
    ..By finding the precise target(s) of albuterol action alternative strategies can be developed to attenuate the incidence of sarcopenia. [unreadable] [unreadable] [unreadable]..
  3. Nutrition and Anabolic Interventions in Cancer Cachexia
    Melinda Sheffield-Moore; Fiscal Year: 2013
    ..Results from this study may lead to better ways of preventing cancer-related weight loss, and improve the quality of life and survival of those affected by cervical cancer. ..
  4. Identification of key tumor cell-released factors that induce cachexia
    Yi Ping Li; Fiscal Year: 2013
    ....
  5. Eicosapentaenoic acid and protein modulation to induce anabolism in COPD
    MARIELLE PKJ ENGELEN; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The results of this study should provide the basis for a new nutritional formulation to support protein anabolism and improve overall outcome in cachectic patients with Chronic Obstructive Pulmonary Disease. ..
  6. Gene Networks Regulating Muscle Protein Degradation
    Nathaniel J Szewczyk; Fiscal Year: 2010
    ....
  7. CONTROL OF MUSCLE PROTEIN SYNTHESIS DURING MYOGENESIS
    Charles P Emerson; Fiscal Year: 2013
    ....
  8. Cullin mediated protein turnover in skeletal and cardiac muscles
    Stephan Lange; Fiscal Year: 2012
    ..Intriguingly, several components involved in the ubiquitylation of muscle proteins are localized along myofibrils, like the muscle specific E3-ligases of the MuRF protein family...
  9. Nutrition, Inflammation and Insulin Resistance in End-Stage Renal Disease
    Talat Alp Ikizler; Fiscal Year: 2013
    ..abstract_text> ..
  10. Surveillance and Epidemiologic Research of Duchenne and Becker Muscular Dystrophy
    CHARLOTTE MARIE DRUSCHEL; Fiscal Year: 2010
    ....
  11. Omega-3 Fatty Acid Administration In Dialysis Patients
    Talat Alp Ikizler; Fiscal Year: 2010
    ..We propose to test if reducing inflammation with an anti-inflammatory treatment (Omega-3 fatty acids in this case) will reduce inflammation and muscle loss in dialysis patients. ..
  12. Regulation of Muscle ATP Synthase Beta Subunit Metabolism in Obesity
    Christos S Katsanos; Fiscal Year: 2013
    ..Further, they will provide scientific knowledge to base lifestyle interventions to improve muscle ATP turnover in obese individuals. ..
  13. COX Inhibition & Musculoskeletal Responses to Exercise
    Wendy M Kohrt; Fiscal Year: 2010
    ..Therefore, knowledge of whether a drug as widely used as ibuprofen impairs the beneficial adaptations to exercise is deemed to be of high clinical significance. ..
  14. Cullin mediated protein turnover in skeletal and cardiac muscles
    Stephan Lange; Fiscal Year: 2013
    ..Intriguingly, several components involved in the ubiquitylation of muscle proteins are localized along myofibrils, like the muscle specific E3-ligases of the MuRF protein family...
  15. Structual and Calcium Regulatory Proteins in Sarcopenia
    LaDora V Thompson; Fiscal Year: 2012
    ..We hypothesize that age-dependent damage of specific amino acid residues in key skeletal muscle proteins impacts skeletal muscle performance by altering protein structure and function...
  16. PGC1alpha and Irisin in the Control of Diabetes and Obesity
    Bruce M Spiegelman; Fiscal Year: 2013
    ..Together these studies should lend important insights into the basic science of muscle and exercise as well as open new avenues for the rapid development of new therapeutics. ..
  17. Site-Directed Oxidative Modification of Muscle Protein Structural Dynamics
    David D Thomas; Fiscal Year: 2013
    ..of this research is to understand the functional and structural consequences of site-specific oxidation in muscle proteins, in order to illuminate the mechanisms by which oxidative stress affects human health and aging...
  18. Atrogin-1 and Muscle Protein Balance
    Stewart H Lecker; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Atrogin-1 is part of a complex that triggers the destruction of muscle proteins, and its activation leads to muscle wasting...
  19. CONTROL OF MUSCLE PROTEIN SYNTHESIS DURING MYOGENESIS
    Charles P Emerson; Fiscal Year: 2010
    ..abstract_text> ..
  20. Structural and functional effects of oxidative modification of myosin
    REBECCA J MOEN; Fiscal Year: 2013
    ..program in the Thomas lab is to understand the structural and functional basis of oxidative modification of muscle proteins, in order to determine the molecular basis of decline in muscle strength due to aging and degenerative ..
  21. MicroRNA and Muscle Wasting in Uremia
    XIAONAN H WANG; Fiscal Year: 2013
    ..These results should provide new approaches for developing therapeutic strategies to correct muscle wasting in catabolic disease. ..
  22. NUTRITION &EXERCISE TO IMPROVE PROTEIN METABOLISM &PREVENT SARCOPENIA IN AGING
    Elena Volpi; Fiscal Year: 2013
    ..muscle protein synthesis, normalizes muscle perfusion, and reduces the age-related insulin resistance of muscle proteins. Thus, aerobic exercise may improve muscle protein metabolism, strength, function and even mass in older ..
  23. Effects of early exercise on muscle and cardiovascular health after stroke
    RICHARD FRANK MACKO; Fiscal Year: 2013
    ....
  24. Analysis of Z-band assembly and maintenance in living skeletal muscle cells
    JOSEPH WILLIAM SANGER; Fiscal Year: 2013
    ..of the Z-bands of myofibrils inside living skeletal muscle cells via probes encoding fluorescent chimeric GFP-muscle proteins. The first specific aim is to investigate the assembly, the dynamics and proximities of several proteins in ..
  25. Molecular Mechanisms that Cause Muscle Atrophy
    Alfred L Goldberg; Fiscal Year: 2012
    ..it will be important to learn more about MuRF1's function and cofactors in vivo and to identify the muscle proteins that MuRF1 targets for degradation during atrophy...
  26. Regulation of Neonatal Muscle Protein Synthesis
    Teresa A Davis; Fiscal Year: 2012
    ..to test the hypothesis that intermittent bolus feeding promotes greater rates of synthesis of skeletal muscle proteins than continuous feeding, and that this response is mediated by insulin and amino acids through their ..
  27. TrkB.T1 as a Genetic Disease Modifier of Muscular Dystrophy
    CHRISTOPHER WILLIAM WARD; Fiscal Year: 2010
    ..dystrophies are complex genetic diseases characterized by inherited or sporadic defects in genes that encode muscle proteins. Although Duchenne (DMD), Becker, limb girdle, congenital, facioscapulohumeral, myotonic, oculopharyngeal, ..
  28. Effect of Insulin and Propranolol on Post Burn Hypermetabolism and Inflammation
    David N Herndon; Fiscal Year: 2012
    ..abstract_text> ..
  29. Spectroscopic Probes of the Muscle Cytoskeleton
    David D Thomas; Fiscal Year: 2013
    ..between two laboratories - the Thomas laboratory, which leads the world in spectroscopic probes of muscle proteins, and the Ervasti laboratory, which leads the world in the expression and purification of the relevant ..
  30. Cytokine Regulation of Muscle Protein Synthesis During Infection
    Charles H Lang; Fiscal Year: 2013
    ....
  31. PROTEIN NUTRITION IN EXPERIMENTAL UREMIA
    WILLIAM EVANS MITCH; Fiscal Year: 2013
    ..The significance of our results is that the two-hit model could apply to many conditions because GC and decreased insulin responses are present in many catabolic illnesses, ..
  32. Mechanisms of Growth Hormone Resistance in Sepsis
    Robert N Cooney; Fiscal Year: 2010
    ..An improved understanding of how cytokines and growth factors regulate protein catabolism is important to provide better care for these patients. ..
  33. Mitigation of the Catecholamine Surge in Severely Burned Patients
    David N Herndon; Fiscal Year: 2013
    ..Further, this P50 Burn Center will translate this improved understanding and knowledge to clinical outcomes of burns in order to improve the standard of burn care. ..
  34. Mechanisms of protein-energy-wasting in chronic kidney disease
    Zhaoyong Hu; Fiscal Year: 2013
    ..The results of our study might be used to define cell biologic responses that are interrupted by CKD. The results also might yield the initial steps towards designing new therapies for this dreaded complication of CKD. . ..
  35. MYOSIN MOVEMENT IN VITRO-MOLECULAR CHARACTERIZATION
    JAMES ANTHONY SPUDICH; Fiscal Year: 2013
    ..familial cardiomyopathies affecting 1 out of 500 people result from missense mutations in various cardiac muscle proteins, with mutations in beta-cardiac myosin being one of the most common sources of this disease...
  36. PET/CT of skeletal muscle amino acid kinetics
    Thomas F Lang; Fiscal Year: 2013
    ....
  37. Characterization of the Insulin to Autophagy Pathway in Muscles
    Norbert Perrimon; Fiscal Year: 2013
    ....
  38. Mechanisms of Malnutrition in Cirrhosis with Portosystemic Shunting
    Srinivasan Dasarathy; Fiscal Year: 2013
    ..Furthermore, the results from these studies have the potential to be rapidly translated to clinical application by using pharmacological methods to lower ammonia mediated increased myostatin expression. ..
  39. Characterization of Autoreactivity to Muscle Proteins in Inclusion Body Myositis
    Mohammad Salajegheh; Fiscal Year: 2013
    ..Finally, we will compare detailed demographic and clinical data between reactive and non-reactive IBM subjects to determine if we can identify disease subgroups. ..
  40. Oxidative Stress and Myocardial Function
    Marius P Sumandea; Fiscal Year: 2010
    ..S. increases dramatically with age due of oxidative stress. We propose to study how age and oxidative stress modify the structure of heart muscle proteins and change function. We hope to prevent this by the use of antioxidants.
  41. Nutritional and Contractile Regulation of Muscle Growth
    Blake B Rasmussen; Fiscal Year: 2012
    ....
  42. Cellular Signaling and Kidney Function
    Douglas Eaton; Fiscal Year: 2009
    ..The last, Project 4, "Regulation of Urea Transporters in MDCK Cells", examines the regulation of renal urea transport proteins in a new model system. ..
  43. The Role of Protein Turnover in a Drosophila Model of Muscle Atrophy.
    ERIKA RAE GEISBRECHT; Fiscal Year: 2012
    ..A better understanding of the molecular players involved in muscular dystrophies and atrophic muscle must first be established before truly successful therapeutic strategies can be developed. ..
  44. MECHANISM OF MUSCLE WASTING IN AGING MAN
    K Sreekumaran Nair; Fiscal Year: 2013
    ..The proposed studies will apply novel and innovative methodologies developed in our laboratory to address important mechanistic questions that may reveal potential therapeutic targets to combat sarcopenia. ..
  45. MUSCLE STRUCTURE AND THE CONTRACTILE MECHANISM
    Carolyn Cohen; Fiscal Year: 2012
    ....
  46. Regulation of Muscle Autophagy and Mitophagy by Insulin and IGF-1 Signaling
    BRIAN TIMOTHY O'NEILL; Fiscal Year: 2013
    ..This study will elucidate the roles of insulin resistance, altered IGF-1 signaling and diabetes on muscle protein metabolism and hopefully identify therapeutic targets to both decrease muscle atrophy and enhance mitochondrial function. ..
  47. INTERDISCIPLINARY TRAINING PROGRAM IN MUSCLE BIOLOGY
    Martin F Schneider; Fiscal Year: 2013
    ..molecular biological determinants of muscle development and molecular aspects of structure and function of muscle proteins through cell biological aspects of muscle cytoskeleton and matrix, biophysical and physiological analysis of ..
  48. Cyclic compressive loading to negate atrophy and impaired regrowth in aged muscle
    Esther E Dupont-Versteegden; Fiscal Year: 2013
    ..If our results prove beneficial, massage can be directly applied clinically for the maintenance and restoration of muscle size and strength. ..
  49. Muscle Regrowth during Physical Rehabilitation and Amino Acid Supplementation
    HANS CHRISTIAN DREYER; Fiscal Year: 2012
    ..This research will help to restore physical function and independence in the rapidly growing population of older adults with knee arthritis. ..
  50. Identifying the Genetic and Molecular Basis of Clubfoot
    Anita E Beck; Fiscal Year: 2013
    ..S. children <18 years old. The goal of this project is to understand how mutations in genes that encode muscle proteins cause clubfoot in a group of contracture disorders called distal arthrogryposis and test whether variants in ..
  51. Preserving muscle mass and function in bedridden older adults
    Douglas Paddon-Jones; Fiscal Year: 2013
    ..Our novel, minimally invasive and clinically interventions have direct application for older hospitalized patients at risk of accelerated muscle loss and diminished functional capacity. ..
  52. Regulation of Human Muscle Protein Metabolism Following Burn Injury
    EDWARD KELLY MERRITT; Fiscal Year: 2012
    ..These studies will help us understand the molecular and cellular aspects that lead to this muscle loss. Understanding the mechanisms controlling muscle loss after burn will allow for the development of treatments to prevent it. ..
  53. Regulation of Nutrient Sensing and Muscle Wasting by Alcohol
    Charles H Lang; Fiscal Year: 2013
    ....
  54. REGULATION OF SKELETAL MUSCLE METABOLISM
    Leonard S Jefferson; Fiscal Year: 2013
    ..Overall, we expect the proposed research to reveal molecular targets that can likely be manipulated pharmacologically resulting in new and innovative approaches to the prevention and treatment of muscle wasting conditions. ..
  55. Molecular dynamics studies of muscle proteins
    EDWARD F PATE; Fiscal Year: 2010
    Determining the atomic level mechanism by which muscle proteins generate force and motion remains one of the fundamental questions in physiology...
  56. Spectroscopic Probes of Protein-Protein Interactions in Muscle Degeneration
    AVA YUN LIN; Fiscal Year: 2012
    ..This proposal focuses on the interactions of actin with other two other filamentous muscle proteins, dystrophin and utrophin...
  57. Leucine Supplementation to Promote Lean Growth in Early Life
    Teresa A Davis; Fiscal Year: 2013
    ....
  58. Myostatin Family Signaling in Burn-Injury Related Muscle Wasting
    Teresa A Zimmers; Fiscal Year: 2013
    ....
  59. EXERCISE INTERVENTIONS DURING VOLUNTARY WEIGHT LOSS IN OBESE OLDER ADULTS
    Dennis T Villareal; Fiscal Year: 2013
    ..abstract_text> ..
  60. Nutrient regulation of amino acid transporters in aging human skeletal muscle
    Micah J Drummond; Fiscal Year: 2013
    ..The pilot data collected will be used for future R01 submissions to identify mechanisms and novel targets for interventions to improve muscle function and preserve physical independence in older adults. ..
  61. Regulation of actin dynamics during myofibril assembly
    Shoichiro Ono; Fiscal Year: 2013
    ..elegans and humans. Powerful genetic studies on these muscle proteins advanced our knowledge on the mechanism of myofibril assembly and function...
  62. Non-invasive Assessment of Skeletal Muscle Loss in Cancer Patients
    Morteza Janghorbani; Fiscal Year: 2013
    ....
  63. Leica SP5 confocal microscope for live-cell imaging
    Colin J Barnstable; Fiscal Year: 2012
    ..This instrument will enhance a wide variety of public health projects being conducted at the Milton S. Hershey Medical Center, including those related to cancer, diabetes, heart disease, viral infection and neurodegenerative diseases. ..
  64. Refinement of Macromolecular Assembly Structure using Electron Microscopy
    Michael S Chapman; Fiscal Year: 2010
    ..A second goal is a more detailed mechanistic understanding of biomolecular complexes, going beyond domain movements to the internal conformational changes that drive them. ..
  65. Acute Nutritional Deprivation: Diaphragm Influences
    Michael Lewis; Fiscal Year: 2007
    ..of the PI3K/Akt/mTOR signal transduction pathway is an important determinant of disordered synthesis of muscle proteins and atrophy with ND. Reduced IGF-1 levels are a major signal responsible for this down-regulation...
  66. TESTOSTERONE REPLACEMENT & PHYSICAL FUNCTION IN HIV+MEN
    Shalender Bhasin; Fiscal Year: 2005
    ..This study should help identify a therapeutic intervention that might improve physical function in HIV-infected men with weight loss, and enhance our understanding of the mechanisms by which testosterone stimulates muscle accretion. ..
  67. EFFECT OF EXERCISE ON PROTEIN DEGRADATION
    GEORGE KASPEREK; Fiscal Year: 1993
    ..off exercise-induced protein degradation will be probed by measuring the initial events in the degradation of muscle proteins, determining how lysosomes are involved, and determining how the activity of muscle proteinases and their ..
  68. CATECHOLAMINE MODULATION OF THYROID HORMONE METABOLISM
    Harvey Katzeff; Fiscal Year: 1992
    ..hormones on muscle protein content, protein synthesis, DNA and RNA content, and mRNA species of specific muscle proteins during exercise will be performed in thyroidectectomized rats replaced with low, normal or increased levels ..