cerebrospinal fluid proteins

Summary

Summary: Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister's Clinical Neurology, 7th ed, p221)

Top Publications

  1. ncbi Cerebrospinal fluid analysis
    Dean A Seehusen
    Department of Family Practice and Emergency Medical Services, Tripler Army Medical Center, Honolulu, Hawaii, USA
    Am Fam Physician 68:1103-8. 2003
  2. pmc Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methods
    Alfred N Fonteh
    Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA 91101, USA
    Dis Markers 22:39-64. 2006
  3. pmc Cerebrospinal fluid proteomics reveals potential pathogenic changes in the brains of SIV-infected monkeys
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5800, USA
    J Proteome Res 8:2253-60. 2009
  4. pmc 8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease
    Leila Choe
    School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA
    Proteomics 7:3651-60. 2007
  5. ncbi FGF2 plays a key role in embryonic cerebrospinal fluid trophic properties over chick embryo neuroepithelial stem cells
    C Martin
    Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, C Ramón y Cajal 7, 47005 Valladolid, Spain
    Dev Biol 297:402-16. 2006
  6. pmc Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 6:e17287. 2011
  7. ncbi Embryonic cerebrospinal fluid regulates neuroepithelial survival, proliferation, and neurogenesis in chick embryos
    Angel Gato
    Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, Valladolid, Spain
    Anat Rec A Discov Mol Cell Evol Biol 284:475-84. 2005
  8. ncbi Multiplexed proteomic analysis of oxidation and concentrations of cerebrospinal fluid proteins in Alzheimer disease
    Minna A Korolainen
    Department of Neurology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Clin Chem 53:657-65. 2007
  9. pmc Protein analysis in human cerebrospinal fluid: Physiological aspects, current progress and future challenges
    Andreas F Huhmer
    Proteomics, Finnigan Mass Spectrometry, Thermo Electron, San Jose, CA 95134, USA
    Dis Markers 22:3-26. 2006
  10. pmc Alterations in cerebrospinal fluid proteins in a presymptomatic primary glioma model
    John C Whitin
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e49724. 2012

Detail Information

Publications175 found, 100 shown here

  1. ncbi Cerebrospinal fluid analysis
    Dean A Seehusen
    Department of Family Practice and Emergency Medical Services, Tripler Army Medical Center, Honolulu, Hawaii, USA
    Am Fam Physician 68:1103-8. 2003
    ..To prove herpetic, cryptococcal, or tubercular infection, special staining techniques or collection methods may be required...
  2. pmc Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methods
    Alfred N Fonteh
    Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA 91101, USA
    Dis Markers 22:39-64. 2006
    ..Combining lipidomics and proteomics will enhance existing knowledge of disease pathology and increase the likelihood of discovering specific markers and biochemical mechanisms of brain diseases...
  3. pmc Cerebrospinal fluid proteomics reveals potential pathogenic changes in the brains of SIV-infected monkeys
    Gurudutt Pendyala
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5800, USA
    J Proteome Res 8:2253-60. 2009
    ..Finally, we find that the increase in cerebrospinal fluid proteins is linked to increased expression of their genes in the brain parenchyma, revealing that the ..
  4. pmc 8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease
    Leila Choe
    School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA
    Proteomics 7:3651-60. 2007
    ..One conclusion aided by the visualization tool is that there are differences in considering peptide-based observations versus protein-based observations from quantitative shotgun proteomics studies...
  5. ncbi FGF2 plays a key role in embryonic cerebrospinal fluid trophic properties over chick embryo neuroepithelial stem cells
    C Martin
    Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, C Ramón y Cajal 7, 47005 Valladolid, Spain
    Dev Biol 297:402-16. 2006
    ....
  6. pmc Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome
    Steven E Schutzer
    Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
    PLoS ONE 6:e17287. 2011
    ..They share features of fatigue and cognitive dysfunction, making it difficult to differentiate them. Unresolved is whether nPTLS is a subset of CFS...
  7. ncbi Embryonic cerebrospinal fluid regulates neuroepithelial survival, proliferation, and neurogenesis in chick embryos
    Angel Gato
    Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, Valladolid, Spain
    Anat Rec A Discov Mol Cell Evol Biol 284:475-84. 2005
    ..These data strongly suggest that E-CSF is involved in the regulation of neuroepithelial cells behavior, supporting the hypothesis that this fluid plays a key role during the early development of the central nervous system...
  8. ncbi Multiplexed proteomic analysis of oxidation and concentrations of cerebrospinal fluid proteins in Alzheimer disease
    Minna A Korolainen
    Department of Neurology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
    Clin Chem 53:657-65. 2007
    ..Several oxidized carbonylated proteins have been identified in plasma and brain of AD patients by use of 2-dimensional oxyblotting...
  9. pmc Protein analysis in human cerebrospinal fluid: Physiological aspects, current progress and future challenges
    Andreas F Huhmer
    Proteomics, Finnigan Mass Spectrometry, Thermo Electron, San Jose, CA 95134, USA
    Dis Markers 22:3-26. 2006
    ..We also discuss necessary development in methodology in order to have the highest impact on the study of the molecular composition of CSF proteins...
  10. pmc Alterations in cerebrospinal fluid proteins in a presymptomatic primary glioma model
    John C Whitin
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e49724. 2012
    ..We now report an assessment of the CSF proteome to determine the changes in protein composition that occur during this period...
  11. ncbi Proteins in cerebrospinal fluid and blood: barriers, CSF flow rate and source-related dynamics
    Hansotto Reiber
    Neurochemisches Labor der Neurologischen Klinik, Robert Koch Str 40, Universitat Gottingen, D 37075 Gottingen, Germany
    Restor Neurol Neurosci 21:79-96. 2003
    ....
  12. ncbi Pre-analytical factors influencing the stability of cerebrospinal fluid proteins
    Anja H Simonsen
    Memory Disorders Research Group, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Denmark
    J Neurosci Methods 215:234-40. 2013
    ..Standardised CSF sampling, handling and storage for biomarker research are essential for accurately comparing the results obtained by different studies and institutions...
  13. ncbi Multiple sclerosis-related proteins identified in cerebrospinal fluid by advanced mass spectrometry
    Marcel P Stoop
    Laboratories of Neuro Oncology Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Proteomics 8:1576-85. 2008
    ..CSF chromogranin A levels were confirmed to be significantly elevated in the MScl group using an ELISA...
  14. ncbi The impact of blood contamination on the proteome of cerebrospinal fluid
    Jin Sam You
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Proteomics 5:290-6. 2005
    ..This analysis was aimed at identification of proteins found primarily in CSF, those found primarily in blood and assessment of the impact of blood contamination on those proteins found in both fluids...
  15. ncbi Studies of potential cerebrospinal fluid molecular markers for Alzheimer's disease
    Leila H Choe
    120 Olin Hall, School of Chemical and Biomolecular Engineering, Ithaca, NY 14583 5201, USA
    Electrophoresis 23:2247-51. 2002
    ..The use of panels of molecular markers derived from proteomic analysis may offer the best prospect for developing molecular diagnostic tests for complex neurodegenerative disorders such as AD...
  16. ncbi Identification of potential CSF biomarkers in ALS
    G M Pasinetti
    Geriatric Research, Education, and Clinical Center, Bronx Veterans Affairs Medical Center, Bronx, NY, USA
    Neurology 66:1218-22. 2006
    ..The clinical diagnosis of ALS is based entirely on clinical features. Identification of biomarkers for ALS would be important for diagnosis and might also provide clues to pathogenesis...
  17. ncbi Integrated analysis of the cerebrospinal fluid peptidome and proteome
    Alexandre Zougman
    Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    J Proteome Res 7:386-99. 2008
    ..The CSF proteome has only partial overlap with the plasma proteome, thus it is produced locally rather than deriving from plasma. Our work offers insights into CSF composition and origin...
  18. ncbi Identification of proteins from human cerebrospinal fluid, separated by two-dimensional polyacrylamide gel electrophoresis
    A Sickmann
    Institut fur Physiologische Chemie, Ruhr Universitat Bochum, Germany
    Electrophoresis 21:2721-8. 2000
    ..To date we have been able to identify more than 65 spots from 2-D gels using matrix assisted laser desorption/ionization-mass spectrometry and electrospray ionization-mass spectrometry...
  19. ncbi Differentiating acute bacterial meningitis from acute viral meningitis among children with cerebrospinal fluid pleocytosis: a multivariable regression model
    Bema K Bonsu
    Department of Pediatrics and Division of Emergency Medicine, Children s Hospital, Columbus, OH, USA
    Pediatr Infect Dis J 23:511-7. 2004
    ..In this study, we estimate the accuracy of a simple new model with potentially broader applicability...
  20. ncbi Human cerebrospinal fluid peptidomics
    Xianglin Yuan
    Charles B Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, 847 Monroe Avenue, Memphis, Tennessee 38163, USA
    J Mass Spectrom 40:176-81. 2005
    ..This analytical method is effective for the analysis of the human lumbar CSF peptidome...
  21. ncbi Identification of post-mortem cerebrospinal fluid proteins as potential biomarkers of ischemia and neurodegeneration
    Pierre Lescuyer
    Biomedical Proteomics Research Group, Clinical Chemistry Laboratory, Geneva University Hospital, Switzerland
    Proteomics 4:2234-41. 2004
    ..We recently showed that H-FABP, a protein highly homologous to E-FABP and A-FABP identified in this study, is a potential marker of Creutzfeldt-Jakob disease and stroke...
  22. ncbi Apolipoprotein E and other cerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt-Jakob disease
    Leila H Choe
    120 Olin Hall, School of Chemical and Biomolecular Engineering, Ithaca, NY, USA
    Electrophoresis 23:2242-6. 2002
    ..Analysis of ante mortem CSF may help to differentiate patients with vCJD from those patients with spCJD...
  23. pmc Meningeal derived cerebrospinal fluid proteins in different forms of dementia: is a meningopathy involved in normal pressure hydrocephalus?
    J Brettschneider
    Department of Neurology, University of Ulm, Germany
    J Neurol Neurosurg Psychiatry 75:1614-6. 2004
    ..Because dementia is associated with neuronal loss, we investigated whether leptomeningeal dysfunction may be involved in the pathogenesis of dementia disorders...
  24. ncbi Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era
    Lise E Nigrovic
    Department of Medicine, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 110:712-9. 2002
    ..Children with meningitis are routinely admitted to the hospital and administered broad-spectrum antibiotics pending culture results because distinguishing bacterial meningitis from aseptic meningitis is often difficult...
  25. ncbi The role of cerebrospinal fluid proteins as early diagnostic markers for sporadic Creutzfeldt-Jakob disease
    Catherine Pennington
    The National CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Neurosci Lett 455:56-9. 2009
    ..Our findings indicate that CSF protein markers are effective tests in the early stages of sCJD...
  26. ncbi Characterization of proteome of human cerebrospinal fluid
    Jing Xu
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Int Rev Neurobiol 73:29-98. 2006
  27. ncbi Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's disease
    Maja Puchades
    Unit of Experimental Neuroscience, Department of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital Molndal, S 431 80 Molndal, Goteborg, Sweden
    Brain Res Mol Brain Res 118:140-6. 2003
    ..The levels of 37 proteins spots were altered in AD patients. One of the identified proteins, alpha-2-HS glycoprotein, has not previously been linked to AD. Our study shows that several glycoproteins are altered in AD...
  28. ncbi High sensitivity and specificity of serum procalcitonin levels in adults with bacterial meningitis
    A Viallon
    Emergency and Intensive Care Units and the Immunology Laboratory, Bellevue Hospital, France
    Clin Infect Dis 28:1313-6. 1999
    ..2 ng/mL had a sensitivity and specificity of up to 100% in the diagnosis of bacterial meningitis. Serum procalcitonin levels seem to be the best marker in differentiating between bacterial and viral meningitis in adults...
  29. ncbi Comparative proteomics analysis of cerebrospinal fluid of patients with Guillain-Barré syndrome
    Yin Rong Yang
    Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong, P R China
    Cell Mol Neurobiol 28:737-44. 2008
    ..These identified proteins may be involved in the pathophysiological process of GBS and call for further studying the role of these proteins in the pathogenesis of the disease...
  30. ncbi The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathies
    G Hsich
    Laboratory of Central Nervous System Studies, National Institutes of Health, Bethesda, MD 20892 4122, USA
    N Engl J Med 335:924-30. 1996
    ..Attempts to identify these proteins, however, have been unsuccessful. We hypothesized that they may be present in the normal brain...
  31. ncbi Creutzfeldt-Jakob disease: diagnostic utility of 14-3-3 protein immunodetection in cerebrospinal fluid
    S Collins
    The Australian Creutzfeldt Jakob Disease Registry, Department of Pathology, The University of Melbourne, Victoria, Australia 3010
    J Clin Neurosci 7:203-8. 2000
    ....
  32. ncbi Proteome study of human cerebrospinal fluid following traumatic brain injury indicates fibrin(ogen) degradation products as trauma-associated markers
    Antonio Conti
    Proteomics Unit, San Raffaele Scientific Institute, Milan, Italy
    J Neurotrauma 21:854-63. 2004
    ..The presence of these markers could correlate with a post-traumatic local increase in fibrinolysis as well as to an inflammatory event following CNS tissue injury...
  33. ncbi Quantitative proteomic analysis of the cerebrospinal fluid of patients with multiple sclerosis
    Shilian Liu
    Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong, China
    J Cell Mol Med 13:1586-603. 2009
    ....
  34. ncbi CSF proteome analysis in multiple sclerosis patients by two-dimensional electrophoresis
    D Chiasserini
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy
    Eur J Neurol 15:998-1001. 2008
    ..In this study, we compare CSF proteome of 10 relapsing-remitting MS (RR-MS) patients, 11 patients with clinically isolated syndrome (CIS), and 10 control subjects without neurological or systemic diseases...
  35. ncbi The quest for brain disorder biomarkers
    Christoph W Turck
    Max Planck Institute of Psychiatry, Molecular, Cellular, Clinical Proteomics, Munich, Germany
    J Med Invest 52:231-5. 2005
    ..Our biomarker identification efforts range from classical proteomics approaches such as two dimensional gel electrophoresis and mass spectrometry to phage display screens with cerebrospinal fluid antibodies...
  36. ncbi Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid
    Jing Zhang
    Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
    Neurobiol Aging 26:207-27. 2005
    ..These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases...
  37. ncbi Differential protein expression in male and female human lumbar cerebrospinal fluid using iTRAQ reagents after abundant protein depletion
    Yuko Ogata
    Seattle Biomedical Research Institute, Seattle, WA, USA
    Proteomics 7:3726-34. 2007
    ..We also examined the levels of ceruloplasmin in each individual patient sample which constituted the pooled CSF using Western blot analysis which confirmed the lower expression levels of ceruloplasmin in male CSF...
  38. ncbi Application of targeted quantitative proteomics analysis in human cerebrospinal fluid using a liquid chromatography matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (LC MALDI TOF/TOF) platform
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Proteome Res 7:720-30. 2008
    ....
  39. ncbi CSF proteome analysis in clinically isolated syndrome (CIS): candidate markers for conversion to definite multiple sclerosis
    H Tumani
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Neurosci Lett 452:214-7. 2009
    ..CIS-CIS. For Fetuin-A, our findings could be confirmed by ELISA. The pathophysiological role as well as clinical relevance of these candidate proteins in CIS remains to be further clarified by future studies...
  40. ncbi Accuracy of the cerebrospinal fluid results to differentiate bacterial from non bacterial meningitis, in case of negative gram-stained smear
    Patrick Ray
    Department of Emergency Medicine and Surgery, Centre Hospitalo Universitaire CHU Pitié Salpêtrière, Assistance Publique Hopitaux de Paris AP HP, Universite Pierre et Marie Curie Paris 6, Paris, France
    Am J Emerg Med 25:179-84. 2007
    ..The aim of this study was to evaluate the usefulness of various laboratory results for differential diagnosis of bacterial (BM) and nonbacterial meningitis (NBM) with negative initial Gram stain...
  41. ncbi Cerebrospinal fluid proteome profile in multiple sclerosis
    V Lehmensiek
    Department of Neurology, University of Ulm, 89081, Ulm, Germany
    Mult Scler 13:840-9. 2007
    ..Though the pathophysiological role of these proteins still remains to be elucidated in detail and further validation is needed, these findings may have a relevant impact on the identification of disease-specific markers...
  42. ncbi A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectrometry
    Sheng Pan
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Proteomics 7:469-73. 2007
    ..In total, 2594 proteins were identified in well-characterized pooled human CSF samples using stringent proteomics criteria. This report summarizes our efforts to comprehensively characterize the human CSF proteome to date...
  43. ncbi Cathepsins B and L are markers for clinically invasive types of meningiomas
    T Strojnik
    Department of Neurosurgery, Maribor Teaching Hospital, Ljubljanska, Slovenia
    Neurosurgery 48:598-605. 2001
    ..The aim of this study was to evaluate cathepsins B and L and their inhibitors as new prognostic factors that could distinguish malignant from benign forms of meningiomas...
  44. ncbi Cytotoxicity of ventricular cerebrospinal fluid from Parkinson patients: correlation with clinical profiles and neurochemistry
    George T Mandybur
    Department of Neurosurgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216 4505, USA
    Neurol Res 25:104-11. 2003
    ..The cytotoxic effect of PD-vCSF did not directly correlate with any clinical profiles studied or energy metabolism of PD brain...
  45. ncbi Cerebrospinal fluid from L-dopa-treated Parkinson's disease patients is dystrophic for various neural cell types ex vivo: effects of astroglia
    J A Colombo
    Programa Unidad de Neurobiología Aplicada, PRUNA, CEMIC CONICET, Avenue Galván 4102, Buenos Aires, 1431, Argentina
    Exp Neurol 154:452-63. 1998
    ..The suggestion is made that CSF testing prior to transplantation may aid in anticipating its possible outcome. Cotransplantation of neuronal cells with subcultured astroglia may foster survival and growth of the former cells...
  46. ncbi Separation of human cerebrospinal fluid proteins by capillary isoelectric focusing in the absence of denaturing agents
    T Manabe
    Department of Chemistry, Faculty of Science, Ehime University, Matsuyama, Japan
    Electrophoresis 20:3677-83. 1999
    ..The results of CIEF analysis of CSF samples suggested that the technique will be useful as a survey method to detect specific proteins in CSF, which might relate to disorders in the central nervous system...
  47. ncbi [Electrophoresis of cerebrospinal fluid proteins in patients with ischemic cerebrovascular disease]
    R A Fernández-Carriera
    Instituto de Neurologia y Neurocirugia, La Habana, Cuba
    Rev Neurol 35:908-12. 2002
    ..AIMS. To compare the electrophoretograms of patients with ischemic cerebrovascular disease (ICVD) with those of controls and to link the alterations in the proteinogram with the ICVD subtypes...
  48. ncbi Alterations of the cerebrospinal fluid proteins and subcommissural organ secretion in the arterial hypertension and ventricular dilatation. A study in SHR rats
    I Martinez-Pena y Valenzuela
    Department of Anatomy, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Spain
    Histol Histopathol 21:179-85. 2006
    ..Our results demonstrate that hydrocephalus and hypertension are interconnected in this kind of rat which produce alterations in SCO secretions and some proteins of the CSF...
  49. ncbi Proteomics analysis of prefractionated human lumbar cerebrospinal fluid
    Xianglin Yuan
    Charles B Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, 847 Monroe Avenue, Memphis, TN 38163, USA
    Proteomics 5:541-50. 2005
    ..The prefractionation of CSF proteins with SPE, followed by proteomics analysis, provides a new method to explore low-abundance, disease-specific CSF proteins...
  50. ncbi Brain injury and proteomics/peptidomics: is it relevant? an overview
    M U Schuhmann
    Department of Neurosurgery, University of Leipzig, Leipzig, Germany
    Acta Neurochir Suppl 95:465-70. 2005
    ..Newly "discovered" peptide targets have to be validated with different methodology to establish a real diagnostic or therapeutic value...
  51. ncbi Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters?
    Harmony P Garges
    Pediatrics, Duke University, Durham, North Carolina, USA
    Pediatrics 117:1094-100. 2006
    ..Abnormal cerebrospinal fluid (CSF) parameters are often used to predict neonatal meningitis and determine length and type of antibiotic therapy in neonates with a positive blood culture and negative CSF culture...
  52. ncbi Angiostrongylus cantonensis: efficacy of albendazole-dexamethasone co-therapy against infection-induced plasminogen activators and eosinophilic meningitis
    Wu Chun Tu
    Department of Entomology, National Chung Hsing University, Taichung 402, Taiwan
    Exp Parasitol 113:8-15. 2006
    ..At the same dosage and days post-infection, the earlier administration shows better results. This study showed that albendazole-dexamethasone co-therapy is an effective approach for the treatment of parasitic meningitis...
  53. doi 10 most commonly asked questions about cerebrospinal fluid characteristics in demyelinating disorders of the central nervous system
    Matthias Mehling
    Department of Neurology, University Hospital, Basel, Switzerland
    Neurologist 14:60-5. 2008
  54. ncbi Analysis of the experimental detection of central nervous system-related genes in human brain and cerebrospinal fluid datasets
    Michael Mueller
    EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Proteomics 8:1138-48. 2008
    ..We also evaluate the empirically observed peptides of interest against predictions of their proteotypic character...
  55. ncbi Cerebrospinal fluid proteomics and human immunodeficiency virus dementia: preliminary observations
    Joseph R Berger
    Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0284, USA
    J Neurovirol 11:557-62. 2005
    ..In both serum and CSF samples, differences in protein intensity appeared to correlate with degree of dementia. This preliminary study suggests that protein markers of HIV dementia may be detected by MALDI mass spectrometry...
  56. ncbi [A 26-year-old woman of interval form of acute carbon monoxide intoxication with cerebrospinal fluid abnormalities]
    Yu Kono
    Department of Neurology, Yokohama Rosai Hospital
    No To Shinkei 57:611-5. 2005
    ..So we believe this case is very important for telling us suspected the mechanism and some indications about the treatment of an interval form...
  57. ncbi CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitis
    K L Tyler
    Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Neurology 66:361-5. 2006
    ..To provide a large, comprehensive evaluation of the CSF findings in patients with serologically confirmed West Nile virus (WNV), CNS disease, and their correlation with outcome...
  58. ncbi CSF proteome: a protein repository for potential biomarker identification
    Martin J Romeo
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Expert Rev Proteomics 2:57-70. 2005
    ..b>Cerebrospinal fluid proteins are generally less abundant than their corresponding serum counterparts, necessitating the development ..
  59. pmc The use of proteomics in biomarker discovery in neurodegenerative diseases
    Pia Davidsson
    Discovery Medicine Molecular Sciences, AstraZeneca R and D, Molndal, Sweden
    Dis Markers 21:81-92. 2005
    ....
  60. ncbi Results of cerebrospinal fluid analysis, neurologic examination findings, and age at the onset of seizures as predictors for results of magnetic resonance imaging of the brain in dogs examined because of seizures: 115 cases (1992-2000)
    William W Bush
    Department of Neurology, Veterinary Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    J Am Vet Med Assoc 220:781-4. 2002
    ..To determine whether neurologic examination findings, results of CSF analysis, or age at the onset of seizures could be used to predict whether results of magnetic resonance imaging (MRI) would be normal or abnormal in dogs with seizures...
  61. ncbi Biomarkers for Alzheimer's disease
    Malcolm Ward
    Proteome Sciences plc, South Wing Laboratory PO 045, Institute of Psychiatry, London, SE5 8AF, UK
    Expert Rev Mol Diagn 7:635-46. 2007
    ..This review aims to cover the important field of biomarker research in association with AD...
  62. ncbi High resolution protein electrophoresis of 100 paired canine cerebrospinal fluid and serum
    Sebastien Behr
    Frégis Veterinary Clinique, Arcueil, France
    J Vet Intern Med 20:657-62. 2006
    ..In conclusion, this study did not confirm high resolution electrophoresis of paired CSF and serum samples to be a valuable ancillary diagnostic tool for canine neurological diseases...
  63. ncbi CSF biomarker discovery using label-free nano-LC-MS based proteomic profiling: technical aspects
    Jeffrey T J Huang
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    J Sep Sci 30:214-25. 2007
    ..Our strategy provides a simple and controlled method for CSF biomarker discovery...
  64. pmc Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification
    Hidenaga Yamamori
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
    Neurosci Lett 418:186-9. 2007
    ..A highly significant correlation was found between this assay and a commonly used kit, INNOTEST hTAU Antigen...
  65. ncbi [Differential diagnosis of bacterial and viral meningitis in childhood acute meningitis: a statistical model]
    Neşat Celik
    Dr Sami Ulus Cocuk Sağliği ve Hastaliklari Eğitim ve Araştirma Merkezi, Cocuk Sagligi ve Hastaliklari, Ankara
    Mikrobiyol Bul 41:63-9. 2007
    ..Based on CSF protein and neutrophil ratio which were found as independent variables, the regression model could predict the patients having BM with 95% and viral meningitis with 93.2% accuracy...
  66. ncbi Biomarkers and diagnosis; protein biomarkers in serum of pediatric patients with severe traumatic brain injury identified by ICAT-LC-MS/MS
    Arsalan S Haqqani
    Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada
    J Neurotrauma 24:54-74. 2007
    ..Several proteins with pattern similarity to S100beta identified by hierarchical clustering could be considered for evaluation in a larger patient sample as potential peripheral markers of TBI...
  67. ncbi Identifying pharmacodynamic protein markers of centrally active drugs in humans: a pilot study in a novel clinical model
    Sandeep T Patil
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Proteome Res 6:955-66. 2007
    ..These studies suggest that identification of changes in the CSF proteome associated with the administration of centrally active drugs is feasible, and may be of value in the development of new drugs, as well as broader clinical research...
  68. ncbi Method of intracranial pressure monitoring and cerebrospinal fluid sampling in swine
    Gernot M Kaiser
    Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Germany
    Lab Anim 41:80-5. 2007
    ..At autopsy, no iatrogenic lesions were found and monitoring catheters were still in place. For several types of research requiring ICP monitoring and sampling of CSF, this method can be used successfully...
  69. ncbi Cerebrospinal fluid biomarkers showing neurodegeneration in dogs with GM1 gangliosidosis: possible use for assessment of a therapeutic regimen
    Hiroyuki Satoh
    Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita ku, Sapporo 060 0818, Japan
    Brain Res 1133:200-8. 2007
    ..However, this treatment did not change either the clinical course or the CSF biomarkers of the affected dog, suggesting that glucocorticoid therapy would not be effective for treating GM1 gangliosidosis...
  70. ncbi CSF flow cytometry greatly improves diagnostic accuracy in CNS hematologic malignancies
    J E C Bromberg
    Department of Neuro Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Neurology 68:1674-9. 2007
    ....
  71. ncbi Critical evaluation of the biological role of IgM in cerebrospinal fluid in inflammatory and other diseases of the nervous system
    J Svatonova
    Department of Clinical Biochemistry, Laboratory of Reference for CSF and Neuroimmunology, Homolka Hospital, 150 30 Prague, Czechia
    Folia Microbiol (Praha) 51:485-91. 2006
    ....
  72. pmc Human body fluid proteome analysis
    Shen Hu
    School of Dentistry, Division of Oral Biology and Medicine, Dental Research Institute, University of California, Los Angeles, CA 90095, USA
    Proteomics 6:6326-53. 2006
    ..With the advances made in proteomics technologies, the impact of HBFP analysis in the search for clinically relevant disease biomarkers would be realized in the future...
  73. ncbi Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markers
    Fatima W Khwaja
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proteomics 6:6277-87. 2006
    ..3-13.7 kDa peak range in non-neoplastic CSF and was most prominent in inflammatory conditions. Our approach provides a rational basis for identifying biomarkers that could be used for detection, diagnosis, and monitoring of CNS diseases...
  74. ncbi Intrathecal immunoglobulin G synthesis and brain injury by quantitative MRI in multiple sclerosis
    Carlos O Brandão
    Department of Microbiology and Immunology, Medical School, University of Campinas, Campinas, Brazil
    Neuroimmunomodulation 13:89-95. 2006
    ....
  75. ncbi Plasma and cerebrospinal fluid-based protein biomarkers for motor neuron disease
    Christi Kolarcik
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Mol Diagn Ther 10:281-92. 2006
    ..It is hoped that proteomic technologies will soon integrate the basic biology of ALS with mechanistic disease information to achieve success in the clinical setting...
  76. ncbi Ventricular cerebrospinal fluid neurofilament protein levels decrease in parallel with white matter pathology after shunt surgery in normal pressure hydrocephalus
    M Tullberg
    Institute of Clinical Neuroscience, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Eur J Neurol 14:248-54. 2007
    ..Other biochemical effects of shunting may include increased monoaminergic and peptidergic neurotransmission, breakdown of blood brain barrier function, and gliosis...
  77. ncbi Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's disease
    François Torreilles
    CNRS UMR 5094, Institut de Biotechnologie et Pharmacologie, UFR Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
    Prog Neurobiol 66:191-203. 2002
    ..The present review analyzes the main results of intrathecal content analyses in light of pathogenic theories proposed to explain the damage associated with AD and observed in the brain of patients by postmortem examination...
  78. ncbi Proteomic analysis of the cerebrospinal fluid of patients with schizophrenia
    L Jiang
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
    Amino Acids 25:49-57. 2003
    ..The levels of certain other proteins, like haptoglobin, fibrinogen, complement component 3, and Gc-globulin, were altered in the disease group as well, however, the changes did not reach a statistical significance...
  79. ncbi Findings in cerebrospinal fluids of horses infected with West Nile virus: 30 cases (2001)
    Heather L Wamsley
    Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    J Am Vet Med Assoc 221:1303-5. 2002
    ..To evaluate CSF in horses with confirmed West Nile virus encephalomyelitis...
  80. ncbi CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration
    Kenichi Yasui
    Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    J Neurol Sci 250:120-3. 2006
    ..These findings suggest that loss of orexin neurons or impaired orexin neurotransmission might exist as a part of the neurodegeneration associated with advanced PSP with long duration of morbidity...
  81. ncbi High-throughput proteomics and protein biomarker discovery in an experimental model of inflammatory hyperalgesia: effects of nimesulide
    C Gineste
    Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Drugs 63:23-9. 2003
    ....
  82. ncbi [Reference values in the cerebrospinal fluid of calves between four and eight weeks of age]
    H Stocker
    Departement für Fortpflanzungskunde, Universitat Zurich
    Schweiz Arch Tierheilkd 144:283-8. 2002
    ..The reference range for creatin kinase activity was increased whereas the one for sodium was only slightly increased compared to earlier investigations in calves and in adult bovines...
  83. pmc Early diagnosis of external ventricular drainage infection: results of a prospective study
    W Pfisterer
    Department of Neurosurgery, Donauspital SMZ Ost, Vienna, Austria
    J Neurol Neurosurg Psychiatry 74:929-32. 2003
    ....
  84. ncbi Vasculitis of the spinal cord
    Allan H Ropper
    Neurology Service, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Arch Neurol 60:1791-4. 2003
    ..Vasculitis of the central nervous system is rare but well described. It affects the cerebral hemispheres predominantly and only exceptionally involves the spinal cord...
  85. ncbi [Diagnosis of sleeping sickness stage: towards a new approach]
    V Lejon
    institut de médecine tropicale, Departement de Parasitologie, Nationalestraat 155, B 2000 Antwerpen, Belgique
    Bull Soc Pathol Exot 95:338-40. 2002
    ..Based on our observations on the intrathecal immune response and with LATEX/IgM, we propose a new approach for stage determination in sleeping sickness...
  86. ncbi Composition of cerebrospinal fluid in clinically normal adult ferrets
    Simon R Platt
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    Am J Vet Res 65:758-60. 2004
    ..To determine the protein and cellular composition of CSF in healthy adult ferrets...
  87. ncbi Elevation of CRABP-I in the cerebrospinal fluid of patients with Moyamoya disease
    Seung Ki Kim
    Division of Pediatric Neurosurgery and Laboratory for Fetal Medicine Research in Clinical Research Institute, Seoul National University Hospital, and Neuroscience Research Institute, Seoul National University Medical Research Center, Korea
    Stroke 34:2835-41. 2003
    ..The etiology of moyamoya disease (MMD) remains obscure. This study was undertaken to identify specific proteins associated with the pathogenesis of MMD...
  88. ncbi Serum transthyretin monomer as a possible marker of blood-to-CSF barrier disruption
    Nicola Marchi
    Division of Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, Ohio 44196, USA
    J Neurosci 23:1949-55. 2003
    ..Because TTR is localized primarily in choroid plexus and, as a soluble monomer, in CSF, we concluded that although S-100beta is a marker of BBB integrity, TTR instead may be a peripheral tracer of blood-to-cerebrospinal barrier...
  89. ncbi Diagnosis, treatment, and prognosis of Mycoplasma pneumoniae childhood encephalitis: systematic review of 58 cases
    Florian Daxboeck
    Division of Hospital Hygiene, Clinical Institute for Hygiene and Medical Microbiology, University of Vienna, University Hospital Vienna, Vienna, Austria
    J Child Neurol 19:865-71. 2004
    ..A high cerebrospinal fluid cell count, cerebrospinal fluid protein elevation, and higher age were associated with an unfavorable outcome...
  90. ncbi [Cerebrospinal fluid as informative source of the brain]
    C Ohtsuka
    Juntendo University Urayasu Hospital, Chiba
    No To Hattatsu 23:119-28. 1991
    ..These results suggest that several substances in CSF are useful as markers of brain injury and dysfunction...
  91. ncbi Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants
    J Turchan
    Department of Neurology, Pharmaceutical Sciences, University of Kentucky, Lexington, USA
    Neurology 60:307-14. 2003
    ..To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that may block this oxidative stress...
  92. ncbi Alteration of cystatin C in cerebrospinal fluid of patients with sciatica revealed by a proteomical approach
    Xudong Liu
    Department of Orthopedic Surgery, Shanghai No 6 People s Hospital, Shanghai Jiaotong University, Yishan Road, Shanghai, Peoples Republic of China
    Saudi Med J 26:1699-704. 2005
    ....
  93. ncbi Shunting in hydrocephalus due to tuberculous meningitis. Cases presenting with high cerebrospinal fluid proteins in pediatric age
    B F KiLincoglu
    Department of Neurosurgery, Sisli Etfal Research and Training Hospital, Istanbul, Turkey
    J Neurosurg Sci 53:49-53. 2009
    ..High concentrations of cerebrospinal fluid proteins and elevated cell counts will affect ventricular shunt function...
  94. ncbi [Guillain-Barre syndrome. Experience in a third level hospital]
    J F Tellez-Zenteno
    Rev Invest Clin 53:311-4. 2001
    ..The causes of it are diverse and plentiful. The most common cause of acute paralytic peripheral neuropathy is the Guillain-Barré syndrome (GBS). As many as 85% of those affected can be expected to make an excellent recovery...
  95. pmc Male patient with mild cognitive impairment and extremely high P300 and Slow-wave latencies: a case report
    Vasileios T Papaliagkas
    Department of Experimental Physiology, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Cases J 2:6157. 2009
    ..The patient was assessed with neuropsychometric tests, auditory event-related potentials and cerebrospinal fluid proteins and was diagnosed with mild cognitive impairment...
  96. ncbi Frequency of normal cerebrospinal fluid protein level and leukocyte count in enterovirus meningitis
    Marie L Landry
    J Clin Virol 32:73-4. 2005
  97. ncbi Multiplexed quantification of proteins adsorbed to surface-modified and non-modified microdialysis membranes
    Andreas P Dahlin
    Department of Engineering Sciences, Uppsala University, Uppsala, Sweden
    Anal Bioanal Chem 402:2057-67. 2012
    ..The method has great potential and can be used to study much more complex protein adsorption systems than previously reported...
  98. pmc Elevated immunoglobulin levels in the cerebrospinal fluid from lupus-prone mice
    Michelle M Sidor
    McMaster University, Department of Psychiatry and Behavioural Neurosciences, 1200 Main Street West, Hamilton, Canada L8N 3Z5
    J Neuroimmunol 165:104-13. 2005
    ....
  99. ncbi Proteomic identification of potential protein markers in cerebrospinal fluid of GBS patients
    T Jin
    Department of Neurology, The First Hospital, Jilin University, Changchun, China
    Eur J Neurol 14:563-8. 2007
    ..We concluded that these six proteins may be involved in the pathogenesis of GBS and call for further studying the role of these proteins in the pathogenesis of the disease...
  100. ncbi CSF analysis in patients with sporadic CJD and other transmissible spongiform encephalopathies
    A Green
    National CJD Surveillance Unit, The University of Edinburgh, Edinburgh, UK
    Eur J Neurol 14:121-4. 2007
    ..9 g/l and one patient had detectable oligoclonal IgG. None of the patients with sporadic CJD or other TSEs had abnormalities in all three tests...
  101. ncbi Searching for markers of Creutzfeldt-Jakob disease in cerebrospinal fluid by two-dimensional mapping
    Chiara Piubelli
    Department of Neurological and Visual Sciences, Section of Neurology, University of Verona, Verona, Italy
    Proteomics 6:S256-61. 2006
    ....

Research Grants31

  1. Pinitol a Natural Extract from Pine Cones and Alzheimer's Disease
    Giulio Pasinetti; Fiscal Year: 2006
    ..abstract_text> ..
  2. New Tool to Study Neurochemical Modulation of Feeding
    SCOTT SHIPPY; Fiscal Year: 2005
    ..for maximal protein recovery and the protein content will be determined for the most abundant cerebrospinal fluid proteins. Protease activity in perfusates will be measured and minimized by the use of capillary wall coatings...
  3. CYCLOOXYGENASE AND ANTI-INFLAMMATORY DRUGS IN AD
    Giulio Pasinetti; Fiscal Year: 2001
    ..The outcome of the proposed studies will be immediately relevant to the design of human trials. ..
  4. Rapid seizure-induced changes in dendritic spines
    Michael Wong; Fiscal Year: 2007
    ..Washington University possesses unmatched resources in cutting-edge technology and expert researchers in cellular imaging and represents an ideal environment for the PI to complete the goals of this proposal. ..
  5. Elucidating the Kidney's Role in Cardiovascular Risk
    Michael Shlipak; Fiscal Year: 2004
    ....
  6. Predictors of Alzheimers Disease in Mild Cognitive Impairment
    Oscar Lopez; Fiscal Year: 2007
    ..g., structural and perfusion MRI, plasma beta-amyloid) and the factors that modify the risk to express the clinical syndrome takes on an added importance. [unreadable] [unreadable] [unreadable] [unreadable]..
  7. Proteomic Studies in Parkinson's Disease
    Jing Zhang; Fiscal Year: 2008
    ....
  8. Biomarkers for Parkinson's Disease (PD) and PD Dementia
    Jing Zhang; Fiscal Year: 2008
    ..abstract_text> ..
  9. Mechanisms of virus-induced apoptosis in neurons and CNS
    Kenneth L Tyler; Fiscal Year: 2010
    ..pathways involved, as well as an easily accessible in mouse model of CNS apoptosis that allows rapid testing of results obtained in cell culture for their significance on the pathogenesis of CNS viral disease in vivo ..
  10. Assay to detect early neurologic Lyme disease
    Steven Schutzer; Fiscal Year: 2003
    ..BbIC Ab and Ag will be identified. Focus will be towards on specific and in vivo expressed Bb Ags. Results will be statistically analyzed. Phase 2 will be designed for broadscale usage and refinement. ..
  11. MR PREDICTORS OF RESPONSE TO HAART IN HIV DEMENTIA
    Joseph Berger; Fiscal Year: 2004
    ..It will also open novel avenues for exploring the differential sensitivities of these pathways to HAART, and suggest unique therapeutic options. ..
  12. FMRI in Pre-Symptomatic PS1-related Alzheimer's Disease
    John Ringman; Fiscal Year: 2005
    ..UCI, with its strong dementia research program, growing MRI capabilities and opportunity to collaborate at the nearby UCLA Brain Imaging Center, is an excellent environment for this endeavor. ..
  13. Mechanisms of apoptosis in the central nervous system
    Kenneth Tyler; Fiscal Year: 2009
    ..In addition, the proposed studies will evaluate the role of these genes and pathways as novel therapeutic targets for these diseases. ..
  14. COMPLEMENT AND NEUROPROTECTION: ALZHEIMER'S DISEASE
    Giulio Pasinetti; Fiscal Year: 2002
    ..Further characterization of the complex role of complement proteins in neurodegeneration is essential especially in view of the possibility that the complement system represents a target for therapeutic interventions in AD. ..
  15. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2009
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  16. DITHIOCARBAMATE PESTICIDES IN PARKINSON'S DISEASE
    Jing Zhang; Fiscal Year: 2003
    ..The new information will shed more light on the mechanisms by which pesticides interact with aging and genetic vulnerability thereby contributing to development and progression of PD. ..
  17. JCV Virus Expression in Oropharynx and HIV
    Joseph Berger; Fiscal Year: 2004
    ..This line of investigation would add credence to an oropharyngeal mechanism of JCV transmission and may ultimately lead to the clinical identification of an acute illness attributable to this pathogen. ..
  18. NEUROSCIENCE OF HIV CONFERENCE
    Joseph Berger; Fiscal Year: 2002
    ..Dr. Brian Wigdahl, international co-chair of the ISNV, is a co-investigator on this grant. ..
  19. Complete Proteome of Cerebrospinal Fluid
    Steven Schutzer; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  20. Detection of Virulent Burkholderia mallei
    Steven Schutzer; Fiscal Year: 2006
    ..In Phase 2 we will also develop the immuno-based assays. ..
  21. Rapid and Simple CSF Tests for Neurosyphillis Diagnosis
    Christina Marra; Fiscal Year: 2006
    ..The results of this study will be used to design field trials in the areas of greatest need. ..
  22. ASSAY TO DETECT ACUTE ACTIVE LYME DISEASE
    Steven Schutzer; Fiscal Year: 2005
    ..It can also detect infection early than free antibody assays. Therefore this assay can fulfill a great need in Lyme disease diagnosis and has high market potential. ..
  23. Cell Cycle and COX-2 in a Mouse Model of Alzheimer's
    Giulio Pasinetti; Fiscal Year: 2004
    ....
  24. Heart Failure Incidence and Progression in Renal Disease
    Michael Shlipak; Fiscal Year: 2008
    ..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
  25. Nitric Oxide-Superoxide in Lipid Induced Vascular Diseas
    ZVONIMIR KATUSIC; Fiscal Year: 2005
    ....
  26. Tetrahydrobiopterin: Regulator of Endothelial Function
    ZVONIMIR KATUSIC; Fiscal Year: 2009
    ..This information may help to develop new strategies in prevention and treatment of endothelial dysfunction. . ..
  27. Novel Methods to Access Brain Function in HIV-1
    Christina Marra; Fiscal Year: 2003
    ..abstract_text> ..
  28. Role of Cystatins in Oral Cancer Metastasis
    Nadarajah Vigneswaran; Fiscal Year: 2007
    ..Insights gained from these studies will be used to design therapeutic strategies for restoring immune competence of OSCC patients to prevent and eradicate OSCC metastasis. [unreadable] [unreadable] [unreadable]..
  29. HIV Neuroprotection Workshop
    Joseph Berger; Fiscal Year: 2004
    ..The proposed conference is the first of its kind to highlight neuroprotection in HIV CNS and PNS disorders. By coupling this meeting with the International Symposium on Neurovirology this synergy can be exploited. ..
  30. ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASION
    Christina Marra; Fiscal Year: 2004
    ..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..