Genomes and Genes
cerebrospinal fluid proteins
Summary: Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister's Clinical Neurology, 7th ed, p221)
Publications175 found, 100 shown here
- Cerebrospinal fluid analysisDean A Seehusen
Department of Family Practice and Emergency Medical Services, Tripler Army Medical Center, Honolulu, Hawaii, USA
Am Fam Physician 68:1103-8. 2003..To prove herpetic, cryptococcal, or tubercular infection, special staining techniques or collection methods may be required...
- Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methodsAlfred N Fonteh
Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA 91101, USA
Dis Markers 22:39-64. 2006..Combining lipidomics and proteomics will enhance existing knowledge of disease pathology and increase the likelihood of discovering specific markers and biochemical mechanisms of brain diseases...
- Cerebrospinal fluid proteomics reveals potential pathogenic changes in the brains of SIV-infected monkeysGurudutt Pendyala
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5800, USA
J Proteome Res 8:2253-60. 2009..Finally, we find that the increase in cerebrospinal fluid proteins is linked to increased expression of their genes in the brain parenchyma, revealing that the ..
- 8-plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's diseaseLeila Choe
School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA
Proteomics 7:3651-60. 2007..One conclusion aided by the visualization tool is that there are differences in considering peptide-based observations versus protein-based observations from quantitative shotgun proteomics studies...
- FGF2 plays a key role in embryonic cerebrospinal fluid trophic properties over chick embryo neuroepithelial stem cellsC Martin
Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, C Ramón y Cajal 7, 47005 Valladolid, Spain
Dev Biol 297:402-16. 2006....
- Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndromeSteven E Schutzer
Department of Medicine, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, United States of America
PLoS ONE 6:e17287. 2011..They share features of fatigue and cognitive dysfunction, making it difficult to differentiate them. Unresolved is whether nPTLS is a subset of CFS...
- Embryonic cerebrospinal fluid regulates neuroepithelial survival, proliferation, and neurogenesis in chick embryosAngel Gato
Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, Valladolid, Spain
Anat Rec A Discov Mol Cell Evol Biol 284:475-84. 2005..These data strongly suggest that E-CSF is involved in the regulation of neuroepithelial cells behavior, supporting the hypothesis that this fluid plays a key role during the early development of the central nervous system...
- Multiplexed proteomic analysis of oxidation and concentrations of cerebrospinal fluid proteins in Alzheimer diseaseMinna A Korolainen
Department of Neurology, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
Clin Chem 53:657-65. 2007..Several oxidized carbonylated proteins have been identified in plasma and brain of AD patients by use of 2-dimensional oxyblotting...
- Protein analysis in human cerebrospinal fluid: Physiological aspects, current progress and future challengesAndreas F Huhmer
Proteomics, Finnigan Mass Spectrometry, Thermo Electron, San Jose, CA 95134, USA
Dis Markers 22:3-26. 2006..We also discuss necessary development in methodology in order to have the highest impact on the study of the molecular composition of CSF proteins...
- Alterations in cerebrospinal fluid proteins in a presymptomatic primary glioma modelJohn C Whitin
Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States of America
PLoS ONE 7:e49724. 2012..We now report an assessment of the CSF proteome to determine the changes in protein composition that occur during this period...
- Proteins in cerebrospinal fluid and blood: barriers, CSF flow rate and source-related dynamicsHansotto Reiber
Neurochemisches Labor der Neurologischen Klinik, Robert Koch Str 40, Universitat Gottingen, D 37075 Gottingen, Germany
Restor Neurol Neurosci 21:79-96. 2003....
- Pre-analytical factors influencing the stability of cerebrospinal fluid proteinsAnja H Simonsen
Memory Disorders Research Group, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Denmark
J Neurosci Methods 215:234-40. 2013..Standardised CSF sampling, handling and storage for biomarker research are essential for accurately comparing the results obtained by different studies and institutions...
- Multiple sclerosis-related proteins identified in cerebrospinal fluid by advanced mass spectrometryMarcel P Stoop
Laboratories of Neuro Oncology Clinical and Cancer Proteomics, Department of Neurology, Erasmus University Medical Centre, Rotterdam, The Netherlands
Proteomics 8:1576-85. 2008..CSF chromogranin A levels were confirmed to be significantly elevated in the MScl group using an ELISA...
- The impact of blood contamination on the proteome of cerebrospinal fluidJin Sam You
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA
Proteomics 5:290-6. 2005..This analysis was aimed at identification of proteins found primarily in CSF, those found primarily in blood and assessment of the impact of blood contamination on those proteins found in both fluids...
- Studies of potential cerebrospinal fluid molecular markers for Alzheimer's diseaseLeila H Choe
120 Olin Hall, School of Chemical and Biomolecular Engineering, Ithaca, NY 14583 5201, USA
Electrophoresis 23:2247-51. 2002..The use of panels of molecular markers derived from proteomic analysis may offer the best prospect for developing molecular diagnostic tests for complex neurodegenerative disorders such as AD...
- Identification of potential CSF biomarkers in ALSG M Pasinetti
Geriatric Research, Education, and Clinical Center, Bronx Veterans Affairs Medical Center, Bronx, NY, USA
Neurology 66:1218-22. 2006..The clinical diagnosis of ALS is based entirely on clinical features. Identification of biomarkers for ALS would be important for diagnosis and might also provide clues to pathogenesis...
- Integrated analysis of the cerebrospinal fluid peptidome and proteomeAlexandre Zougman
Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
J Proteome Res 7:386-99. 2008..The CSF proteome has only partial overlap with the plasma proteome, thus it is produced locally rather than deriving from plasma. Our work offers insights into CSF composition and origin...
- Identification of proteins from human cerebrospinal fluid, separated by two-dimensional polyacrylamide gel electrophoresisA Sickmann
Institut fur Physiologische Chemie, Ruhr Universitat Bochum, Germany
Electrophoresis 21:2721-8. 2000..To date we have been able to identify more than 65 spots from 2-D gels using matrix assisted laser desorption/ionization-mass spectrometry and electrospray ionization-mass spectrometry...
- Differentiating acute bacterial meningitis from acute viral meningitis among children with cerebrospinal fluid pleocytosis: a multivariable regression modelBema K Bonsu
Department of Pediatrics and Division of Emergency Medicine, Children s Hospital, Columbus, OH, USA
Pediatr Infect Dis J 23:511-7. 2004..In this study, we estimate the accuracy of a simple new model with potentially broader applicability...
- Human cerebrospinal fluid peptidomicsXianglin Yuan
Charles B Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, 847 Monroe Avenue, Memphis, Tennessee 38163, USA
J Mass Spectrom 40:176-81. 2005..This analytical method is effective for the analysis of the human lumbar CSF peptidome...
- Identification of post-mortem cerebrospinal fluid proteins as potential biomarkers of ischemia and neurodegenerationPierre Lescuyer
Biomedical Proteomics Research Group, Clinical Chemistry Laboratory, Geneva University Hospital, Switzerland
Proteomics 4:2234-41. 2004..We recently showed that H-FABP, a protein highly homologous to E-FABP and A-FABP identified in this study, is a potential marker of Creutzfeldt-Jakob disease and stroke...
- Apolipoprotein E and other cerebrospinal fluid proteins differentiate ante mortem variant Creutzfeldt-Jakob disease from ante mortem sporadic Creutzfeldt-Jakob diseaseLeila H Choe
120 Olin Hall, School of Chemical and Biomolecular Engineering, Ithaca, NY, USA
Electrophoresis 23:2242-6. 2002..Analysis of ante mortem CSF may help to differentiate patients with vCJD from those patients with spCJD...
- Meningeal derived cerebrospinal fluid proteins in different forms of dementia: is a meningopathy involved in normal pressure hydrocephalus?J Brettschneider
Department of Neurology, University of Ulm, Germany
J Neurol Neurosurg Psychiatry 75:1614-6. 2004..Because dementia is associated with neuronal loss, we investigated whether leptomeningeal dysfunction may be involved in the pathogenesis of dementia disorders...
- Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae eraLise E Nigrovic
Department of Medicine, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatrics 110:712-9. 2002..Children with meningitis are routinely admitted to the hospital and administered broad-spectrum antibiotics pending culture results because distinguishing bacterial meningitis from aseptic meningitis is often difficult...
- The role of cerebrospinal fluid proteins as early diagnostic markers for sporadic Creutzfeldt-Jakob diseaseCatherine Pennington
The National CJD Surveillance Unit, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
Neurosci Lett 455:56-9. 2009..Our findings indicate that CSF protein markers are effective tests in the early stages of sCJD...
- Characterization of proteome of human cerebrospinal fluidJing Xu
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA
Int Rev Neurobiol 73:29-98. 2006
- Proteomic studies of potential cerebrospinal fluid protein markers for Alzheimer's diseaseMaja Puchades
Unit of Experimental Neuroscience, Department of Clinical Neuroscience, Goteborg University, Sahlgrenska University Hospital Molndal, S 431 80 Molndal, Goteborg, Sweden
Brain Res Mol Brain Res 118:140-6. 2003..The levels of 37 proteins spots were altered in AD patients. One of the identified proteins, alpha-2-HS glycoprotein, has not previously been linked to AD. Our study shows that several glycoproteins are altered in AD...
- High sensitivity and specificity of serum procalcitonin levels in adults with bacterial meningitisA Viallon
Emergency and Intensive Care Units and the Immunology Laboratory, Bellevue Hospital, France
Clin Infect Dis 28:1313-6. 1999..2 ng/mL had a sensitivity and specificity of up to 100% in the diagnosis of bacterial meningitis. Serum procalcitonin levels seem to be the best marker in differentiating between bacterial and viral meningitis in adults...
- Comparative proteomics analysis of cerebrospinal fluid of patients with Guillain-Barré syndromeYin Rong Yang
Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong, P R China
Cell Mol Neurobiol 28:737-44. 2008..These identified proteins may be involved in the pathophysiological process of GBS and call for further studying the role of these proteins in the pathogenesis of the disease...
- The 14-3-3 brain protein in cerebrospinal fluid as a marker for transmissible spongiform encephalopathiesG Hsich
Laboratory of Central Nervous System Studies, National Institutes of Health, Bethesda, MD 20892 4122, USA
N Engl J Med 335:924-30. 1996..Attempts to identify these proteins, however, have been unsuccessful. We hypothesized that they may be present in the normal brain...
- Creutzfeldt-Jakob disease: diagnostic utility of 14-3-3 protein immunodetection in cerebrospinal fluidS Collins
The Australian Creutzfeldt Jakob Disease Registry, Department of Pathology, The University of Melbourne, Victoria, Australia 3010
J Clin Neurosci 7:203-8. 2000....
- Proteome study of human cerebrospinal fluid following traumatic brain injury indicates fibrin(ogen) degradation products as trauma-associated markersAntonio Conti
Proteomics Unit, San Raffaele Scientific Institute, Milan, Italy
J Neurotrauma 21:854-63. 2004..The presence of these markers could correlate with a post-traumatic local increase in fibrinolysis as well as to an inflammatory event following CNS tissue injury...
- Quantitative proteomic analysis of the cerebrospinal fluid of patients with multiple sclerosisShilian Liu
Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong, China
J Cell Mol Med 13:1586-603. 2009....
- CSF proteome analysis in multiple sclerosis patients by two-dimensional electrophoresisD Chiasserini
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy
Eur J Neurol 15:998-1001. 2008..In this study, we compare CSF proteome of 10 relapsing-remitting MS (RR-MS) patients, 11 patients with clinically isolated syndrome (CIS), and 10 control subjects without neurological or systemic diseases...
- The quest for brain disorder biomarkersChristoph W Turck
Max Planck Institute of Psychiatry, Molecular, Cellular, Clinical Proteomics, Munich, Germany
J Med Invest 52:231-5. 2005..Our biomarker identification efforts range from classical proteomics approaches such as two dimensional gel electrophoresis and mass spectrometry to phage display screens with cerebrospinal fluid antibodies...
- Quantitative proteomic analysis of age-related changes in human cerebrospinal fluidJing Zhang
Division of Neuropathology, University of Washington School of Medicine, Box 359635, Harborview Medical Center, Seattle, WA 98104, USA
Neurobiol Aging 26:207-27. 2005..These data not only expand substantially our current knowledge regarding human CSF proteins, but also supply the necessary information to appropriately interpret protein biomarkers of age-related neurodegenerative diseases...
- Differential protein expression in male and female human lumbar cerebrospinal fluid using iTRAQ reagents after abundant protein depletionYuko Ogata
Seattle Biomedical Research Institute, Seattle, WA, USA
Proteomics 7:3726-34. 2007..We also examined the levels of ceruloplasmin in each individual patient sample which constituted the pooled CSF using Western blot analysis which confirmed the lower expression levels of ceruloplasmin in male CSF...
- Application of targeted quantitative proteomics analysis in human cerebrospinal fluid using a liquid chromatography matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometer (LC MALDI TOF/TOF) platformSheng Pan
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
J Proteome Res 7:720-30. 2008....
- CSF proteome analysis in clinically isolated syndrome (CIS): candidate markers for conversion to definite multiple sclerosisH Tumani
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
Neurosci Lett 452:214-7. 2009..CIS-CIS. For Fetuin-A, our findings could be confirmed by ELISA. The pathophysiological role as well as clinical relevance of these candidate proteins in CIS remains to be further clarified by future studies...
- Accuracy of the cerebrospinal fluid results to differentiate bacterial from non bacterial meningitis, in case of negative gram-stained smearPatrick Ray
Department of Emergency Medicine and Surgery, Centre Hospitalo Universitaire CHU Pitié Salpêtrière, Assistance Publique Hopitaux de Paris AP HP, Universite Pierre et Marie Curie Paris 6, Paris, France
Am J Emerg Med 25:179-84. 2007..The aim of this study was to evaluate the usefulness of various laboratory results for differential diagnosis of bacterial (BM) and nonbacterial meningitis (NBM) with negative initial Gram stain...
- Cerebrospinal fluid proteome profile in multiple sclerosisV Lehmensiek
Department of Neurology, University of Ulm, 89081, Ulm, Germany
Mult Scler 13:840-9. 2007..Though the pathophysiological role of these proteins still remains to be elucidated in detail and further validation is needed, these findings may have a relevant impact on the identification of disease-specific markers...
- A combined dataset of human cerebrospinal fluid proteins identified by multi-dimensional chromatography and tandem mass spectrometrySheng Pan
Department of Pathology, University of Washington, Seattle, WA 98104, USA
Proteomics 7:469-73. 2007..In total, 2594 proteins were identified in well-characterized pooled human CSF samples using stringent proteomics criteria. This report summarizes our efforts to comprehensively characterize the human CSF proteome to date...
- Cathepsins B and L are markers for clinically invasive types of meningiomasT Strojnik
Department of Neurosurgery, Maribor Teaching Hospital, Ljubljanska, Slovenia
Neurosurgery 48:598-605. 2001..The aim of this study was to evaluate cathepsins B and L and their inhibitors as new prognostic factors that could distinguish malignant from benign forms of meningiomas...
- Cytotoxicity of ventricular cerebrospinal fluid from Parkinson patients: correlation with clinical profiles and neurochemistryGeorge T Mandybur
Department of Neurosurgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216 4505, USA
Neurol Res 25:104-11. 2003..The cytotoxic effect of PD-vCSF did not directly correlate with any clinical profiles studied or energy metabolism of PD brain...
- Cerebrospinal fluid from L-dopa-treated Parkinson's disease patients is dystrophic for various neural cell types ex vivo: effects of astrogliaJ A Colombo
Programa Unidad de Neurobiología Aplicada, PRUNA, CEMIC CONICET, Avenue Galván 4102, Buenos Aires, 1431, Argentina
Exp Neurol 154:452-63. 1998..The suggestion is made that CSF testing prior to transplantation may aid in anticipating its possible outcome. Cotransplantation of neuronal cells with subcultured astroglia may foster survival and growth of the former cells...
- Separation of human cerebrospinal fluid proteins by capillary isoelectric focusing in the absence of denaturing agentsT Manabe
Department of Chemistry, Faculty of Science, Ehime University, Matsuyama, Japan
Electrophoresis 20:3677-83. 1999..The results of CIEF analysis of CSF samples suggested that the technique will be useful as a survey method to detect specific proteins in CSF, which might relate to disorders in the central nervous system...
- [Electrophoresis of cerebrospinal fluid proteins in patients with ischemic cerebrovascular disease]R A Fernández-Carriera
Instituto de Neurologia y Neurocirugia, La Habana, Cuba
Rev Neurol 35:908-12. 2002..AIMS. To compare the electrophoretograms of patients with ischemic cerebrovascular disease (ICVD) with those of controls and to link the alterations in the proteinogram with the ICVD subtypes...
- Alterations of the cerebrospinal fluid proteins and subcommissural organ secretion in the arterial hypertension and ventricular dilatation. A study in SHR ratsI Martinez-Pena y Valenzuela
Department of Anatomy, Faculty of Medicine, University of La Laguna, La Laguna, Tenerife, Spain
Histol Histopathol 21:179-85. 2006..Our results demonstrate that hydrocephalus and hypertension are interconnected in this kind of rat which produce alterations in SCO secretions and some proteins of the CSF...
- Proteomics analysis of prefractionated human lumbar cerebrospinal fluidXianglin Yuan
Charles B Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, 847 Monroe Avenue, Memphis, TN 38163, USA
Proteomics 5:541-50. 2005..The prefractionation of CSF proteins with SPE, followed by proteomics analysis, provides a new method to explore low-abundance, disease-specific CSF proteins...
- Brain injury and proteomics/peptidomics: is it relevant? an overviewM U Schuhmann
Department of Neurosurgery, University of Leipzig, Leipzig, Germany
Acta Neurochir Suppl 95:465-70. 2005..Newly "discovered" peptide targets have to be validated with different methodology to establish a real diagnostic or therapeutic value...
- Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters?Harmony P Garges
Pediatrics, Duke University, Durham, North Carolina, USA
Pediatrics 117:1094-100. 2006..Abnormal cerebrospinal fluid (CSF) parameters are often used to predict neonatal meningitis and determine length and type of antibiotic therapy in neonates with a positive blood culture and negative CSF culture...
- Angiostrongylus cantonensis: efficacy of albendazole-dexamethasone co-therapy against infection-induced plasminogen activators and eosinophilic meningitisWu Chun Tu
Department of Entomology, National Chung Hsing University, Taichung 402, Taiwan
Exp Parasitol 113:8-15. 2006..At the same dosage and days post-infection, the earlier administration shows better results. This study showed that albendazole-dexamethasone co-therapy is an effective approach for the treatment of parasitic meningitis...
- 10 most commonly asked questions about cerebrospinal fluid characteristics in demyelinating disorders of the central nervous systemMatthias Mehling
Department of Neurology, University Hospital, Basel, Switzerland
Neurologist 14:60-5. 2008
- Analysis of the experimental detection of central nervous system-related genes in human brain and cerebrospinal fluid datasetsMichael Mueller
EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Proteomics 8:1138-48. 2008..We also evaluate the empirically observed peptides of interest against predictions of their proteotypic character...
- Cerebrospinal fluid proteomics and human immunodeficiency virus dementia: preliminary observationsJoseph R Berger
Department of Neurology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0284, USA
J Neurovirol 11:557-62. 2005..In both serum and CSF samples, differences in protein intensity appeared to correlate with degree of dementia. This preliminary study suggests that protein markers of HIV dementia may be detected by MALDI mass spectrometry...
- [A 26-year-old woman of interval form of acute carbon monoxide intoxication with cerebrospinal fluid abnormalities]Yu Kono
Department of Neurology, Yokohama Rosai Hospital
No To Shinkei 57:611-5. 2005..So we believe this case is very important for telling us suspected the mechanism and some indications about the treatment of an interval form...
- CSF findings in 250 patients with serologically confirmed West Nile virus meningitis and encephalitisK L Tyler
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Neurology 66:361-5. 2006..To provide a large, comprehensive evaluation of the CSF findings in patients with serologically confirmed West Nile virus (WNV), CNS disease, and their correlation with outcome...
- CSF proteome: a protein repository for potential biomarker identificationMartin J Romeo
Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Expert Rev Proteomics 2:57-70. 2005..b>Cerebrospinal fluid proteins are generally less abundant than their corresponding serum counterparts, necessitating the development ..
- The use of proteomics in biomarker discovery in neurodegenerative diseasesPia Davidsson
Discovery Medicine Molecular Sciences, AstraZeneca R and D, Molndal, Sweden
Dis Markers 21:81-92. 2005....
- Results of cerebrospinal fluid analysis, neurologic examination findings, and age at the onset of seizures as predictors for results of magnetic resonance imaging of the brain in dogs examined because of seizures: 115 cases (1992-2000)William W Bush
Department of Neurology, Veterinary Hospital of the University of Pennsylvania, Philadelphia 19104, USA
J Am Vet Med Assoc 220:781-4. 2002..To determine whether neurologic examination findings, results of CSF analysis, or age at the onset of seizures could be used to predict whether results of magnetic resonance imaging (MRI) would be normal or abnormal in dogs with seizures...
- Biomarkers for Alzheimer's diseaseMalcolm Ward
Proteome Sciences plc, South Wing Laboratory PO 045, Institute of Psychiatry, London, SE5 8AF, UK
Expert Rev Mol Diagn 7:635-46. 2007..This review aims to cover the important field of biomarker research in association with AD...
- High resolution protein electrophoresis of 100 paired canine cerebrospinal fluid and serumSebastien Behr
Frégis Veterinary Clinique, Arcueil, France
J Vet Intern Med 20:657-62. 2006..In conclusion, this study did not confirm high resolution electrophoresis of paired CSF and serum samples to be a valuable ancillary diagnostic tool for canine neurological diseases...
- CSF biomarker discovery using label-free nano-LC-MS based proteomic profiling: technical aspectsJeffrey T J Huang
Institute of Biotechnology, University of Cambridge, Cambridge, UK
J Sep Sci 30:214-25. 2007..Our strategy provides a simple and controlled method for CSF biomarker discovery...
- Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplificationHidenaga Yamamori
Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA
Neurosci Lett 418:186-9. 2007..A highly significant correlation was found between this assay and a commonly used kit, INNOTEST hTAU Antigen...
- [Differential diagnosis of bacterial and viral meningitis in childhood acute meningitis: a statistical model]Neşat Celik
Dr Sami Ulus Cocuk Sağliği ve Hastaliklari Eğitim ve Araştirma Merkezi, Cocuk Sagligi ve Hastaliklari, Ankara
Mikrobiyol Bul 41:63-9. 2007..Based on CSF protein and neutrophil ratio which were found as independent variables, the regression model could predict the patients having BM with 95% and viral meningitis with 93.2% accuracy...
- Biomarkers and diagnosis; protein biomarkers in serum of pediatric patients with severe traumatic brain injury identified by ICAT-LC-MS/MSArsalan S Haqqani
Institute for Biological Sciences, National Research Council of Canada, Ottawa, Canada
J Neurotrauma 24:54-74. 2007..Several proteins with pattern similarity to S100beta identified by hierarchical clustering could be considered for evaluation in a larger patient sample as potential peripheral markers of TBI...
- Identifying pharmacodynamic protein markers of centrally active drugs in humans: a pilot study in a novel clinical modelSandeep T Patil
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
J Proteome Res 6:955-66. 2007..These studies suggest that identification of changes in the CSF proteome associated with the administration of centrally active drugs is feasible, and may be of value in the development of new drugs, as well as broader clinical research...
- Method of intracranial pressure monitoring and cerebrospinal fluid sampling in swineGernot M Kaiser
Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Germany
Lab Anim 41:80-5. 2007..At autopsy, no iatrogenic lesions were found and monitoring catheters were still in place. For several types of research requiring ICP monitoring and sampling of CSF, this method can be used successfully...
- Cerebrospinal fluid biomarkers showing neurodegeneration in dogs with GM1 gangliosidosis: possible use for assessment of a therapeutic regimenHiroyuki Satoh
Laboratory of Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita ku, Sapporo 060 0818, Japan
Brain Res 1133:200-8. 2007..However, this treatment did not change either the clinical course or the CSF biomarkers of the affected dog, suggesting that glucocorticoid therapy would not be effective for treating GM1 gangliosidosis...
- CSF flow cytometry greatly improves diagnostic accuracy in CNS hematologic malignanciesJ E C Bromberg
Department of Neuro Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
Neurology 68:1674-9. 2007....
- Critical evaluation of the biological role of IgM in cerebrospinal fluid in inflammatory and other diseases of the nervous systemJ Svatonova
Department of Clinical Biochemistry, Laboratory of Reference for CSF and Neuroimmunology, Homolka Hospital, 150 30 Prague, Czechia
Folia Microbiol (Praha) 51:485-91. 2006....
- Human body fluid proteome analysisShen Hu
School of Dentistry, Division of Oral Biology and Medicine, Dental Research Institute, University of California, Los Angeles, CA 90095, USA
Proteomics 6:6326-53. 2006..With the advances made in proteomics technologies, the impact of HBFP analysis in the search for clinically relevant disease biomarkers would be realized in the future...
- Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markersFatima W Khwaja
Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
Proteomics 6:6277-87. 2006..3-13.7 kDa peak range in non-neoplastic CSF and was most prominent in inflammatory conditions. Our approach provides a rational basis for identifying biomarkers that could be used for detection, diagnosis, and monitoring of CNS diseases...
- Intrathecal immunoglobulin G synthesis and brain injury by quantitative MRI in multiple sclerosisCarlos O Brandão
Department of Microbiology and Immunology, Medical School, University of Campinas, Campinas, Brazil
Neuroimmunomodulation 13:89-95. 2006....
- Plasma and cerebrospinal fluid-based protein biomarkers for motor neuron diseaseChristi Kolarcik
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Mol Diagn Ther 10:281-92. 2006..It is hoped that proteomic technologies will soon integrate the basic biology of ALS with mechanistic disease information to achieve success in the clinical setting...
- Ventricular cerebrospinal fluid neurofilament protein levels decrease in parallel with white matter pathology after shunt surgery in normal pressure hydrocephalusM Tullberg
Institute of Clinical Neuroscience, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
Eur J Neurol 14:248-54. 2007..Other biochemical effects of shunting may include increased monoaminergic and peptidergic neurotransmission, breakdown of blood brain barrier function, and gliosis...
- Pathogenic theories and intrathecal analysis of the sporadic form of Alzheimer's diseaseFrançois Torreilles
CNRS UMR 5094, Institut de Biotechnologie et Pharmacologie, UFR Pharmacie, 15 Avenue Charles Flahault, 34093 Montpellier Cedex 5, France
Prog Neurobiol 66:191-203. 2002..The present review analyzes the main results of intrathecal content analyses in light of pathogenic theories proposed to explain the damage associated with AD and observed in the brain of patients by postmortem examination...
- Proteomic analysis of the cerebrospinal fluid of patients with schizophreniaL Jiang
Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China
Amino Acids 25:49-57. 2003..The levels of certain other proteins, like haptoglobin, fibrinogen, complement component 3, and Gc-globulin, were altered in the disease group as well, however, the changes did not reach a statistical significance...
- Findings in cerebrospinal fluids of horses infected with West Nile virus: 30 cases (2001)Heather L Wamsley
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
J Am Vet Med Assoc 221:1303-5. 2002..To evaluate CSF in horses with confirmed West Nile virus encephalomyelitis...
- CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degenerationKenichi Yasui
Department of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
J Neurol Sci 250:120-3. 2006..These findings suggest that loss of orexin neurons or impaired orexin neurotransmission might exist as a part of the neurodegeneration associated with advanced PSP with long duration of morbidity...
- High-throughput proteomics and protein biomarker discovery in an experimental model of inflammatory hyperalgesia: effects of nimesulideC Gineste
Neuroinflammation Research Laboratories, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Drugs 63:23-9. 2003....
- [Reference values in the cerebrospinal fluid of calves between four and eight weeks of age]H Stocker
Departement für Fortpflanzungskunde, Universitat Zurich
Schweiz Arch Tierheilkd 144:283-8. 2002..The reference range for creatin kinase activity was increased whereas the one for sodium was only slightly increased compared to earlier investigations in calves and in adult bovines...
- Early diagnosis of external ventricular drainage infection: results of a prospective studyW Pfisterer
Department of Neurosurgery, Donauspital SMZ Ost, Vienna, Austria
J Neurol Neurosurg Psychiatry 74:929-32. 2003....
- Vasculitis of the spinal cordAllan H Ropper
Neurology Service, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
Arch Neurol 60:1791-4. 2003..Vasculitis of the central nervous system is rare but well described. It affects the cerebral hemispheres predominantly and only exceptionally involves the spinal cord...
- [Diagnosis of sleeping sickness stage: towards a new approach]V Lejon
institut de médecine tropicale, Departement de Parasitologie, Nationalestraat 155, B 2000 Antwerpen, Belgique
Bull Soc Pathol Exot 95:338-40. 2002..Based on our observations on the intrathecal immune response and with LATEX/IgM, we propose a new approach for stage determination in sleeping sickness...
- Composition of cerebrospinal fluid in clinically normal adult ferretsSimon R Platt
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
Am J Vet Res 65:758-60. 2004..To determine the protein and cellular composition of CSF in healthy adult ferrets...
- Elevation of CRABP-I in the cerebrospinal fluid of patients with Moyamoya diseaseSeung Ki Kim
Division of Pediatric Neurosurgery and Laboratory for Fetal Medicine Research in Clinical Research Institute, Seoul National University Hospital, and Neuroscience Research Institute, Seoul National University Medical Research Center, Korea
Stroke 34:2835-41. 2003..The etiology of moyamoya disease (MMD) remains obscure. This study was undertaken to identify specific proteins associated with the pathogenesis of MMD...
- Serum transthyretin monomer as a possible marker of blood-to-CSF barrier disruptionNicola Marchi
Division of Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, Ohio 44196, USA
J Neurosci 23:1949-55. 2003..Because TTR is localized primarily in choroid plexus and, as a soluble monomer, in CSF, we concluded that although S-100beta is a marker of BBB integrity, TTR instead may be a peripheral tracer of blood-to-cerebrospinal barrier...
- Diagnosis, treatment, and prognosis of Mycoplasma pneumoniae childhood encephalitis: systematic review of 58 casesFlorian Daxboeck
Division of Hospital Hygiene, Clinical Institute for Hygiene and Medical Microbiology, University of Vienna, University Hospital Vienna, Vienna, Austria
J Child Neurol 19:865-71. 2004..A high cerebrospinal fluid cell count, cerebrospinal fluid protein elevation, and higher age were associated with an unfavorable outcome...
- [Cerebrospinal fluid as informative source of the brain]C Ohtsuka
Juntendo University Urayasu Hospital, Chiba
No To Hattatsu 23:119-28. 1991..These results suggest that several substances in CSF are useful as markers of brain injury and dysfunction...
- Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidantsJ Turchan
Department of Neurology, Pharmaceutical Sciences, University of Kentucky, Lexington, USA
Neurology 60:307-14. 2003..To determine the role of oxidative stress in mediating HIV dementia and to identify novel therapeutic compounds that may block this oxidative stress...
- Alteration of cystatin C in cerebrospinal fluid of patients with sciatica revealed by a proteomical approachXudong Liu
Department of Orthopedic Surgery, Shanghai No 6 People s Hospital, Shanghai Jiaotong University, Yishan Road, Shanghai, Peoples Republic of China
Saudi Med J 26:1699-704. 2005....
- Shunting in hydrocephalus due to tuberculous meningitis. Cases presenting with high cerebrospinal fluid proteins in pediatric ageB F KiLincoglu
Department of Neurosurgery, Sisli Etfal Research and Training Hospital, Istanbul, Turkey
J Neurosurg Sci 53:49-53. 2009..High concentrations of cerebrospinal fluid proteins and elevated cell counts will affect ventricular shunt function...
- [Guillain-Barre syndrome. Experience in a third level hospital]J F Tellez-Zenteno
Rev Invest Clin 53:311-4. 2001..The causes of it are diverse and plentiful. The most common cause of acute paralytic peripheral neuropathy is the Guillain-Barré syndrome (GBS). As many as 85% of those affected can be expected to make an excellent recovery...
- Male patient with mild cognitive impairment and extremely high P300 and Slow-wave latencies: a case reportVasileios T Papaliagkas
Department of Experimental Physiology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Cases J 2:6157. 2009..The patient was assessed with neuropsychometric tests, auditory event-related potentials and cerebrospinal fluid proteins and was diagnosed with mild cognitive impairment...
- Frequency of normal cerebrospinal fluid protein level and leukocyte count in enterovirus meningitisMarie L Landry
J Clin Virol 32:73-4. 2005
- Multiplexed quantification of proteins adsorbed to surface-modified and non-modified microdialysis membranesAndreas P Dahlin
Department of Engineering Sciences, Uppsala University, Uppsala, Sweden
Anal Bioanal Chem 402:2057-67. 2012..The method has great potential and can be used to study much more complex protein adsorption systems than previously reported...
- Elevated immunoglobulin levels in the cerebrospinal fluid from lupus-prone miceMichelle M Sidor
McMaster University, Department of Psychiatry and Behavioural Neurosciences, 1200 Main Street West, Hamilton, Canada L8N 3Z5
J Neuroimmunol 165:104-13. 2005....
- Proteomic identification of potential protein markers in cerebrospinal fluid of GBS patientsT Jin
Department of Neurology, The First Hospital, Jilin University, Changchun, China
Eur J Neurol 14:563-8. 2007..We concluded that these six proteins may be involved in the pathogenesis of GBS and call for further studying the role of these proteins in the pathogenesis of the disease...
- CSF analysis in patients with sporadic CJD and other transmissible spongiform encephalopathiesA Green
National CJD Surveillance Unit, The University of Edinburgh, Edinburgh, UK
Eur J Neurol 14:121-4. 2007..9 g/l and one patient had detectable oligoclonal IgG. None of the patients with sporadic CJD or other TSEs had abnormalities in all three tests...
- Searching for markers of Creutzfeldt-Jakob disease in cerebrospinal fluid by two-dimensional mappingChiara Piubelli
Department of Neurological and Visual Sciences, Section of Neurology, University of Verona, Verona, Italy
Proteomics 6:S256-61. 2006....
- Pinitol a Natural Extract from Pine Cones and Alzheimer's DiseaseGiulio Pasinetti; Fiscal Year: 2006..abstract_text> ..
- New Tool to Study Neurochemical Modulation of FeedingSCOTT SHIPPY; Fiscal Year: 2005..for maximal protein recovery and the protein content will be determined for the most abundant cerebrospinal fluid proteins. Protease activity in perfusates will be measured and minimized by the use of capillary wall coatings...
- CYCLOOXYGENASE AND ANTI-INFLAMMATORY DRUGS IN ADGiulio Pasinetti; Fiscal Year: 2001..The outcome of the proposed studies will be immediately relevant to the design of human trials. ..
- Rapid seizure-induced changes in dendritic spinesMichael Wong; Fiscal Year: 2007..Washington University possesses unmatched resources in cutting-edge technology and expert researchers in cellular imaging and represents an ideal environment for the PI to complete the goals of this proposal. ..
- Elucidating the Kidney's Role in Cardiovascular RiskMichael Shlipak; Fiscal Year: 2004....
- Predictors of Alzheimers Disease in Mild Cognitive ImpairmentOscar Lopez; Fiscal Year: 2007..g., structural and perfusion MRI, plasma beta-amyloid) and the factors that modify the risk to express the clinical syndrome takes on an added importance. [unreadable] [unreadable] [unreadable] [unreadable]..
- Proteomic Studies in Parkinson's DiseaseJing Zhang; Fiscal Year: 2008....
- Biomarkers for Parkinson's Disease (PD) and PD DementiaJing Zhang; Fiscal Year: 2008..abstract_text> ..
- Mechanisms of virus-induced apoptosis in neurons and CNSKenneth L Tyler; Fiscal Year: 2010..pathways involved, as well as an easily accessible in mouse model of CNS apoptosis that allows rapid testing of results obtained in cell culture for their significance on the pathogenesis of CNS viral disease in vivo ..
- Assay to detect early neurologic Lyme diseaseSteven Schutzer; Fiscal Year: 2003..BbIC Ab and Ag will be identified. Focus will be towards on specific and in vivo expressed Bb Ags. Results will be statistically analyzed. Phase 2 will be designed for broadscale usage and refinement. ..
- MR PREDICTORS OF RESPONSE TO HAART IN HIV DEMENTIAJoseph Berger; Fiscal Year: 2004..It will also open novel avenues for exploring the differential sensitivities of these pathways to HAART, and suggest unique therapeutic options. ..
- FMRI in Pre-Symptomatic PS1-related Alzheimer's DiseaseJohn Ringman; Fiscal Year: 2005..UCI, with its strong dementia research program, growing MRI capabilities and opportunity to collaborate at the nearby UCLA Brain Imaging Center, is an excellent environment for this endeavor. ..
- Mechanisms of apoptosis in the central nervous systemKenneth Tyler; Fiscal Year: 2009..In addition, the proposed studies will evaluate the role of these genes and pathways as novel therapeutic targets for these diseases. ..
- COMPLEMENT AND NEUROPROTECTION: ALZHEIMER'S DISEASEGiulio Pasinetti; Fiscal Year: 2002..Further characterization of the complex role of complement proteins in neurodegeneration is essential especially in view of the possibility that the complement system represents a target for therapeutic interventions in AD. ..
- Proteomics of Cerebrospinal Fluid in Chronic Fatigue SyndromeJames Baraniuk; Fiscal Year: 2009..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
- DITHIOCARBAMATE PESTICIDES IN PARKINSON'S DISEASEJing Zhang; Fiscal Year: 2003..The new information will shed more light on the mechanisms by which pesticides interact with aging and genetic vulnerability thereby contributing to development and progression of PD. ..
- JCV Virus Expression in Oropharynx and HIVJoseph Berger; Fiscal Year: 2004..This line of investigation would add credence to an oropharyngeal mechanism of JCV transmission and may ultimately lead to the clinical identification of an acute illness attributable to this pathogen. ..
- NEUROSCIENCE OF HIV CONFERENCEJoseph Berger; Fiscal Year: 2002..Dr. Brian Wigdahl, international co-chair of the ISNV, is a co-investigator on this grant. ..
- Complete Proteome of Cerebrospinal FluidSteven Schutzer; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Detection of Virulent Burkholderia malleiSteven Schutzer; Fiscal Year: 2006..In Phase 2 we will also develop the immuno-based assays. ..
- Rapid and Simple CSF Tests for Neurosyphillis DiagnosisChristina Marra; Fiscal Year: 2006..The results of this study will be used to design field trials in the areas of greatest need. ..
- ASSAY TO DETECT ACUTE ACTIVE LYME DISEASESteven Schutzer; Fiscal Year: 2005..It can also detect infection early than free antibody assays. Therefore this assay can fulfill a great need in Lyme disease diagnosis and has high market potential. ..
- Cell Cycle and COX-2 in a Mouse Model of Alzheimer'sGiulio Pasinetti; Fiscal Year: 2004....
- Heart Failure Incidence and Progression in Renal DiseaseMichael Shlipak; Fiscal Year: 2008..In persons with established heart failure and CRI, the combination of proBNP, hsCRP, and troponin-T may be optimal for risk stratification and informing long-term prognosis. ..
- Nitric Oxide-Superoxide in Lipid Induced Vascular DiseasZVONIMIR KATUSIC; Fiscal Year: 2005....
- Tetrahydrobiopterin: Regulator of Endothelial FunctionZVONIMIR KATUSIC; Fiscal Year: 2009..This information may help to develop new strategies in prevention and treatment of endothelial dysfunction. . ..
- Novel Methods to Access Brain Function in HIV-1Christina Marra; Fiscal Year: 2003..abstract_text> ..
- Role of Cystatins in Oral Cancer MetastasisNadarajah Vigneswaran; Fiscal Year: 2007..Insights gained from these studies will be used to design therapeutic strategies for restoring immune competence of OSCC patients to prevent and eradicate OSCC metastasis. [unreadable] [unreadable] [unreadable]..
- HIV Neuroprotection WorkshopJoseph Berger; Fiscal Year: 2004..The proposed conference is the first of its kind to highlight neuroprotection in HIV CNS and PNS disorders. By coupling this meeting with the International Symposium on Neurovirology this synergy can be exploited. ..
- ROLE OF T PALLIDUM MSP-HOMOLOGUES IN CNS INVASIONChristina Marra; Fiscal Year: 2004..These investigations are most applicable to persons who are also infected with HIV-1, as they are at greatest risk for syphilis and neurosyphilis. ..