cell cycle proteins

Summary

Summary: Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and phosphoprotein phosphatases (PHOSPHOPROTEIN PHOSPHATASE) as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.

Top Publications

  1. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
  2. ncbi Mechanism of eukaryotic homologous recombination
    Joseph San Filippo
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
    Annu Rev Biochem 77:229-57. 2008
  3. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010
  4. ncbi DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    Christopher J Bakkenist
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Nature 421:499-506. 2003
  5. ncbi A DNA damage checkpoint response in telomere-initiated senescence
    Fabrizio d'Adda di Fagagna
    1 The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK 2 Present address IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nature 426:194-8. 2003
  6. pmc A quantitative atlas of mitotic phosphorylation
    Noah Dephoure
    Department of Cell Biology, Harvard University Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:10762-7. 2008
  7. ncbi Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    Lee Zou
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 300:1542-8. 2003
  8. pmc Human CtIP promotes DNA end resection
    Alessandro A Sartori
    The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 450:509-14. 2007
  9. ncbi Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    M Serrano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 88:593-602. 1997
  10. ncbi Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Nature 444:633-7. 2006

Research Grants

  1. ARGINASE AND ARTERIAL INJURY
    William Durante; Fiscal Year: 2009
  2. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
  3. Cell Cycle Pathways and Spinal Cord Injury
    ALAN IRA FADEN; Fiscal Year: 2011
  4. Molecular mechanisms of C/EBP alpha mediated growth arrest
    Nikolai A Timchenko; Fiscal Year: 2013
  5. Receptor/Ligand Signals for Ovarian Follicular Angiogenesis
    Leon J Spicer; Fiscal Year: 2010
  6. Role of Cyclins in Brain Construction and Interneuron Genesis
    KRISTIN GIAMANCO; Fiscal Year: 2013
  7. Genetics and Biology of CIZ1 in Cervical Dystonia
    Mark S Ledoux; Fiscal Year: 2013
  8. B-RAF Regulation of the Cell Cycle in Melanoma
    Andrew E Aplin; Fiscal Year: 2013
  9. Mechanistic regulation of tumor specific forms of cyclin E in breast cancer
    NIKKI A DELK; Fiscal Year: 2010
  10. Cell Cycle and Podocytes
    STUART JAMES SHANKLAND; Fiscal Year: 2013

Detail Information

Publications290 found, 100 shown here

  1. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
    ..This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals...
  2. ncbi Mechanism of eukaryotic homologous recombination
    Joseph San Filippo
    Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
    Annu Rev Biochem 77:229-57. 2008
    ..Recent progress on elucidating the mechanisms of action of Rad51 and Dmc1 and their cohorts of ancillary factors is reviewed here...
  3. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell...
  4. ncbi DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    Christopher J Bakkenist
    Department of Hematology Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA
    Nature 421:499-506. 2003
    ....
  5. ncbi A DNA damage checkpoint response in telomere-initiated senescence
    Fabrizio d'Adda di Fagagna
    1 The Wellcome Trust Cancer Research UK Institute of Cancer and Developmental Biology, University of Cambridge, Cambridge CB2 1QR, UK 2 Present address IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Nature 426:194-8. 2003
    ..Thus, we propose that telomere-initiated senescence reflects a DNA damage checkpoint response that is activated with a direct contribution from dysfunctional telomeres...
  6. pmc A quantitative atlas of mitotic phosphorylation
    Noah Dephoure
    Department of Cell Biology, Harvard University Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:10762-7. 2008
    ..Analysis of non-proline site-containing phosphopeptides identified two unique motifs that suggest there are at least two undiscovered mitotic kinases...
  7. ncbi Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    Lee Zou
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 300:1542-8. 2003
    ..Our data suggest that RPA-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling...
  8. pmc Human CtIP promotes DNA end resection
    Alessandro A Sartori
    The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 450:509-14. 2007
    ..These findings establish evolutionarily conserved roles for CtIP-like proteins in controlling DSB resection, checkpoint signalling and homologous recombination...
  9. ncbi Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    M Serrano
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 88:593-602. 1997
    ..Negation of ras-induced senescence may be relevant during multistep tumorigenesis...
  10. ncbi Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, DK 2100 Copenhagen, Denmark
    Nature 444:633-7. 2006
    ..Thus, senescence in human preneoplastic lesions is a manifestation of oncogene-induced DNA replication stress and, together with apoptosis, provides a barrier to malignant progression...
  11. ncbi DNA double-strand breaks: signaling, repair and the cancer connection
    K K Khanna
    The Queensland Institute of Medical Research, and Department of Pathology, University of Queensland, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Nat Genet 27:247-54. 2001
    ..Moreover, we discuss how tumor suppressor proteins such as p53, ATM, Brca1 and Brca2 have been linked to such pathways, and how accumulating evidence is connecting deficiencies in cellular responses to DNA DSBs with tumorigenesis...
  12. ncbi DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    Jirina Bartkova
    Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen, Denmark
    Nature 434:864-70. 2005
    ..Mutations compromising this checkpoint, including defects in the ATM-Chk2-p53 pathway, might allow cell proliferation, survival, increased genomic instability and tumour progression...
  13. pmc Exome sequencing reveals VCP mutations as a cause of familial ALS
    Janel O Johnson
    Neuromuscular Diseases Research Group, Laboratory of Neurogenetics, Porter Neuroscience Building, NIA, NIH, Bethesda, MD 20892, USA
    Neuron 68:857-64. 2010
    ....
  14. pmc A global protein kinase and phosphatase interaction network in yeast
    Ashton Breitkreutz
    Centre for Systems Biology, Samuel Lunenfeld Research Institute, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Science 328:1043-6. 2010
    ..An extensive backbone of kinase-kinase interactions cross-connects the proteome and may serve to coordinate diverse cellular responses...
  15. ncbi Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    Masashi Narita
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Cell 113:703-16. 2003
    ..These results provide a molecular explanation for the stability of the senescent state, as well as new insights into the action of Rb as a tumor suppressor...
  16. ncbi ATM activation by oxidative stress
    Zhi Guo
    Howard Hughes Medical Institute, Department of Molecular Genetics and Microbiology, and Institute for Cellular and Molecular Biology ICMB, University of Texas at Austin, Austin, TX 78712, USA
    Science 330:517-21. 2010
    ..Identification of this pathway explains observations of ATM activation under conditions of oxidative stress and shows that ATM is an important sensor of reactive oxygen species in human cells...
  17. ncbi Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    Robbie Loewith
    Division of Biochemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Mol Cell 10:457-68. 2002
    ..Thus, the distinct TOR complexes account for the diversity, specificity, and selective rapamycin inhibition of TOR signaling. TORC1 and possibly TORC2 are conserved from yeast to man...
  18. ncbi Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
    A J Bannister
    Wellcome CRC Institute and Department of Pathology, University of Cambridge, UK
    Nature 410:120-4. 2001
    ..This model may also explain the stable inheritance of the heterochromatic state...
  19. ncbi Cohesin: its roles and mechanisms
    Kim Nasmyth
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    Annu Rev Genet 43:525-58. 2009
    ..Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits...
  20. ncbi Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
    Hemmo Meyer
    Centre for Medical Biotechnology, Faculty of Biology, University of Duisburg Essen, 45117 Essen, Germany
    Nat Cell Biol 14:117-23. 2012
    ..These findings extend the functional relevance of p97 to lysosomal degradation and reveal a surprising dual role in protecting cells from protein stress and ensuring genome stability during proliferation...
  21. ncbi FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
    Markus Welcker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Rev Cancer 8:83-93. 2008
    ..This Review focuses on structural and functional aspects of FBW7 and its role in the development of cancer...
  22. ncbi Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)
    Utz Herbig
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
    Mol Cell 14:501-13. 2004
    ..Distinct senescence programs can thus progress in parallel, resulting in mosaic cultures as well as individual cells responding to multiple signals...
  23. pmc Cohesin, condensin, and the intramolecular centromere loop together generate the mitotic chromatin spring
    Andrew D Stephens
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 193:1167-80. 2011
    ..Together with the intramolecular centromere loop, these SMC complexes constitute a molecular spring that balances spindle microtubule force in metaphase...
  24. ncbi Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
    Martin F Lavin
    Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia
    Nat Rev Mol Cell Biol 9:759-69. 2008
    ....
  25. ncbi The spindle-assembly checkpoint in space and time
    Andrea Musacchio
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Nat Rev Mol Cell Biol 8:379-93. 2007
    ..These studies are finally starting to reveal the mechanisms of checkpoint activation and silencing during mitotic progression...
  26. ncbi Cohesins: chromosomal proteins that prevent premature separation of sister chromatids
    C Michaelis
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 91:35-45. 1997
    ..Proteins homologous to Scc1p exist in a variety of eukaryotic organisms including humans. A common cohesion apparatus might be used by all eukaryotic cells during both mitosis and meiosis...
  27. ncbi Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
    Ning Zheng
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Nature 416:703-9. 2002
    ..The structure suggests that Cul1 may contribute to catalysis through the positioning of the substrate and the ubiquitin-conjugating enzyme, and this model is supported by Cul1 mutations designed to eliminate the rigidity of the scaffold...
  28. ncbi Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    Eros Lazzerini Denchi
    Laboratory for Cell Biology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 448:1068-71. 2007
    ..The results reveal how mammalian telomeres use multiple mechanisms to avoid DNA damage surveillance and provide an explanation for the induction of replicative senescence and genome instability by shortened telomeres...
  29. ncbi Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy
    Klaus Strebhardt
    Department of Obstetrics and Gynaecology, School of Medicine, J W Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Nat Rev Drug Discov 9:643-60. 2010
    ..In this article, recent insights into the biology of PLKs will be reviewed, with an emphasis on their role in malignant transformation, and progress in the development of small-molecule PLK1 inhibitors will be examined...
  30. pmc TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
    Nobumichi Ohoka
    Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya, Japan
    EMBO J 24:1243-55. 2005
    ..These results indicate that TRB3 is a novel target of CHOP/ATF4 and downregulates its own induction by repression of CHOP/ATF4 functions, and that it is involved in CHOP-dependent cell death during ER stress...
  31. ncbi Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
    Ingrid E Wertz
    Department of Early Discovery Biochemistry, Genentech, South San Francisco, California 94080, USA
    Nature 471:110-4. 2011
    ..Our findings suggest that profiling the FBW7 and MCL1 status of tumours, in terms of protein levels, messenger RNA levels and genetic status, could be useful to predict the response of patients to antitubulin chemotherapeutics...
  32. ncbi ATM and related protein kinases: safeguarding genome integrity
    Yosef Shiloh
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Rev Cancer 3:155-68. 2003
    ..Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers...
  33. ncbi Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms
    A Satyanarayana
    Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    Oncogene 28:2925-39. 2009
    ..Nevertheless, cell-cycle-independent functions of Cdks and cyclins such as in DNA damage repair are still under investigation. Here we review the compensatory mechanisms among major cyclins and Cdks in mammalian cell-cycle regulation...
  34. pmc Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
    Q Liu
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 14:1448-59. 2000
    ..Taken together, these data indicate that Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression, and that Atr regulates Chk1...
  35. ncbi hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts
    Shian Wu
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 114:445-56. 2003
    ..A human homolog of hpo completely rescues the overgrowth phenotype of Drosophila hpo mutants, suggesting that hpo might play a conserved role for growth control in mammals...
  36. pmc HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle
    Matthew A Deardorff
    Division of Human Genetics and Molecular Biology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Nature 489:313-7. 2012
    ....
  37. ncbi DMC1: a meiosis-specific yeast homolog of E. coli recA required for recombination, synaptonemal complex formation, and cell cycle progression
    D K Bishop
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Cell 69:439-56. 1992
    ..DMC1 is homologous to yeast's RAD51 gene, supporting the view that mitotic DSB repair has been recruited for use in meiotic chromosome metabolism...
  38. pmc Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis
    Veronica Cloud
    Committee on Genetics, University of Chicago, Cummings Life Science Center, 920 East 58th Street, Chicago, IL 60637, USA
    Science 337:1222-5. 2012
    ..We further provide biochemical evidence that Rad51 acts with Mei5-Sae3 as a Dmc1 accessory factor. Thus, Rad51 is a multifunctional protein that catalyzes recombination directly in mitosis and indirectly, via Dmc1, during meiosis...
  39. ncbi Cohesin: a catenase with separate entry and exit gates?
    Kim Nasmyth
    University of Oxford, Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, UK
    Nat Cell Biol 13:1170-7. 2011
    ....
  40. ncbi Systematic genetic analysis with ordered arrays of yeast deletion mutants
    A H Tong
    Banting and Best Department of Medical Research, University of Toronto, Toronto ON, Canada M5G 1L6
    Science 294:2364-8. 2001
    ..Systematic application of this approach should produce a global map of gene function...
  41. ncbi The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
    Y Ye
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 414:652-6. 2001
    ..We propose that the Cdc48/p97-Ufd1-Npl4 complex extracts proteins from the ER membrane for cytosolic degradation...
  42. pmc Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptor
    Paula C A da Fonseca
    Section of Structural Biology, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
    Nature 470:274-8. 2011
    ..Our results rationalize the contribution of both co-activator and core APC/C subunits to D-box recognition and provide a structural framework for understanding mechanisms of substrate recognition and catalysis by the APC/C...
  43. pmc BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
    Amitabh V Nimonkar
    Department of Microbiology, University of California at Davis, Davis, California 95616, USA
    Genes Dev 25:350-62. 2011
    ..BLM increases the affinity of EXO1 for ends, and MRN recruits and enhances the processivity of EXO1. Our results establish two of the core machineries that initiate recombinational DNA repair in human cells...
  44. pmc Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer
    David Frescas
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    Nat Rev Cancer 8:438-49. 2008
    ....
  45. pmc BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
    Y Wang
    Verna and Mars McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 14:927-39. 2000
    ..Collectively, these results suggest that BRCA1 may function as a coordinator of multiple activities required for maintenance of genomic integrity during the process of DNA replication and point to a central role for BRCA1 in DNA repair...
  46. ncbi A system for stable expression of short interfering RNAs in mammalian cells
    Thijn R Brummelkamp
    Division of Molecular Carcinogenesis, Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, Netherlands
    Science 296:550-3. 2002
    ..Therefore, the pSUPER vector constitutes a new and powerful system to analyze gene function in a variety of mammalian cell types...
  47. ncbi ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    S Burma
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    J Biol Chem 276:42462-7. 2001
    ..Our results clearly establish ATM as the major kinase involved in the phosphorylation of H2AX and suggest that ATM is one of the earliest kinases to be activated in the cellular response to double-strand breaks...
  48. ncbi SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
    A C Carrano
    Department of Pathology, New York University Medical Center, New York 10016, USA
    Nat Cell Biol 1:193-9. 1999
    ..Thus, p27 degradation is subject to dual control by the accumulation of both SKP2 and cyclins following mitogenic stimulation...
  49. pmc RNAi-mediated targeting of heterochromatin by the RITS complex
    Andre Verdel
    Department of Cell Biology, Harvard Medical School, Boston, MA02115, USA
    Science 303:672-6. 2004
    ..The results suggest a mechanism for the role of the RNAi machinery and small RNAs in targeting of heterochromatin complexes and epigenetic gene silencing at specific chromosomal loci...
  50. ncbi Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    W Gu
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Cell 90:595-606. 1997
    ..These results have significant implications regarding the molecular mechanisms of various acetyltransferase-containing transcriptional coactivators whose primary targets have been presumed to be histones...
  51. ncbi TOR, a central controller of cell growth
    T Schmelzle
    Department of Biochemistry, Biozentrum, University of Basel, Switzerland
    Cell 103:253-62. 2000
    ....
  52. ncbi Cell death by mitotic catastrophe: a molecular definition
    Maria Castedo
    CNRS UMR 8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille Desmoulins, Villejuif F 94805, France
    Oncogene 23:2825-37. 2004
    ....
  53. ncbi Posttranslational mechanisms regulate the mammalian circadian clock
    C Lee
    Department of Neurobiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Cell 107:855-67. 2001
    ..We also provide in vivo evidence that casein kinase I delta is a second clock relevant kinase...
  54. pmc ATM controls meiotic double-strand-break formation
    Julian Lange
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA
    Nature 479:237-40. 2011
    ..Our findings explain previously puzzling phenotypes of Atm-null mice and provide a molecular basis for the gonadal dysgenesis observed in ataxia telangiectasia, the human syndrome caused by ATM deficiency...
  55. pmc The ancient and evolving roles of cohesin in gene expression and DNA repair
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA
    Curr Biol 22:R240-50. 2012
    ..Here we survey the roles of cohesin in gene regulation and DNA repair, and how these functions vary from yeast to man...
  56. ncbi Enhanced phosphorylation of p53 by ATM in response to DNA damage
    S Banin
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Science 281:1674-7. 1998
    ..Various damage-induced responses may be activated by enhancement of the protein kinase activity of ATM...
  57. ncbi ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    Aaron A Goodarzi
    Genome Damage and Stability Centre, University of Sussex, East Sussex BN1 9RQ, UK
    Mol Cell 31:167-77. 2008
    ..These data suggest that the importance of ATM signaling for DSB repair increases as the heterochromatic component of a genome expands...
  58. ncbi Ubiquitin ligases: cell-cycle control and cancer
    Keiichi I Nakayama
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Fukuoka 812 8582, Japan
    Nat Rev Cancer 6:369-81. 2006
    ..A better understanding of the ubiquitylation machinery will provide new insights into the regulatory biology of cell-cycle transitions and the development of anti-cancer drugs...
  59. ncbi Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    C E Canman
    The Johns Hopkins School of Medicine, Oncology Center, Baltimore, MD 21205, USA
    Science 281:1677-9. 1998
    ..These observations, along with the fact that phosphorylation of p53 on serine-15 in response to ionizing radiation is reduced in ataxia telangiectasia cells, suggest that ATM is a protein kinase that phosphorylates p53 in vivo...
  60. pmc SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
    Hiroyuki Inuzuka
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 471:104-9. 2011
    ..Therefore, our work provides insight into the molecular mechanism of direct tumour suppression by FBW7 and has implications for the targeted treatment of patients with FBW7-deficient T-ALL...
  61. pmc The ATM protein kinase and cellular redox signaling: beyond the DNA damage response
    Scott Ditch
    The Howard Hughes Medical Institute, The Department of Molecular Genetics and Microbiology, The University of Texas at Austin, Austin, TX 78712, USA
    Trends Biochem Sci 37:15-22. 2012
    ....
  62. ncbi AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    R H Medema
    Department of Hematology, University Medical Center, Utrecht, The Netherlands
    Nature 404:782-7. 2000
    ..We conclude that AFX-like proteins are involved in cell-cycle regulation and that inactivation of these proteins is an important step in oncogenic transformation...
  63. pmc Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells
    Eran Meshorer
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Cell 10:105-16. 2006
    ....
  64. pmc A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
    Ji Luo
    Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cell 137:835-48. 2009
    ..Our results suggest a previously underappreciated role for Ras in mitotic progression and demonstrate a pharmacologically tractable pathway for the potential treatment of cancers harboring Ras mutations...
  65. pmc ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
    Claudia Cosentino
    Genome Stability Unit, Clare Laboratories, London Research Institute, Cancer Research UK, South Mimms, UK
    EMBO J 30:546-55. 2011
    ..These data suggest that ATM protects cells from ROS accumulation by stimulating NADPH production and promoting the synthesis of nucleotides required for the repair of DSBs...
  66. ncbi The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo
    Loning Fu
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell 111:41-50. 2002
    ..Our studies suggest that the mPer2 gene functions in tumor suppression by regulating DNA damage-responsive pathways...
  67. pmc A CTCF-independent role for cohesin in tissue-specific transcription
    Dominic Schmidt
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom
    Genome Res 20:578-88. 2010
    ....
  68. pmc ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
    Angela Alexander
    Department of Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    Proc Natl Acad Sci U S A 107:4153-8. 2010
    ....
  69. ncbi Resetting of circadian time in peripheral tissues by glucocorticoid signaling
    A Balsalobre
    , Sciences II, , 30 Quai Ernest Ansermet, , Switzerland
    Science 289:2344-7. 2000
    ..In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day...
  70. ncbi PCNA, the maestro of the replication fork
    George Lucian Moldovan
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18 82152 Martinsried, Germany
    Cell 129:665-79. 2007
    ..Switching of PCNA partners may be triggered by affinity-driven competition, phosphorylation, proteolysis, and modification of PCNA by ubiquitin and SUMO...
  71. ncbi Regulation of DNA double-strand break repair pathway choice
    Meena Shrivastav
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine and Cancer Center, Albuquerque, NM 87131, USA
    Cell Res 18:134-47. 2008
    ....
  72. ncbi Surviving the breakup: the DNA damage checkpoint
    Jacob C Harrison
    Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02445, USA
    Annu Rev Genet 40:209-35. 2006
    ..Following DNA repair, the checkpoint pathway is inactivated in a process termed recovery. A related but genetically distinct process, adaptation, controls cell cycle re-entry in the face of unrepairable damage...
  73. ncbi Shared and separate functions of polo-like kinases and aurora kinases in cancer
    Susanne M A Lens
    Department of Medical Oncology and Cancer Genomics Centre, UMC Utrecht, Universiteitsweg 100, Stratenum 2 118, Utrecht 3584 CG, The Netherlands
    Nat Rev Cancer 10:825-41. 2010
    ..In this Review we discuss the implications of these novel insights on the clinical applicability of polo-like kinase and aurora kinase inhibitors...
  74. ncbi Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
    J Gyuris
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Cell 75:791-803. 1993
    ..These experiments identify Cdi1 as a novel type of protein phosphatase that forms complexes with cyclin-dependent kinases...
  75. pmc Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    Tony S Byun
    Department of Molecular Pharmacology, Stanford University, Stanford, CA 94305, USA
    Genes Dev 19:1040-52. 2005
    ....
  76. pmc The life and miracles of kinetochores
    Stefano Santaguida
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    EMBO J 28:2511-31. 2009
    ..In this review, we discuss how the molecular organization of the four modules allows a dynamic integration of kinetochore-microtubule attachment with the prevention of chromosome segregation errors and cell-cycle progression...
  77. ncbi Polo-like kinases: conservation and divergence in their functions and regulation
    Vincent Archambault
    Cancer Research UK, Cell Cycle Genetics Research Group, University of Cambridge, Department of Genetics, Downing Street, Cambridge, CB2 3EH, UK
    Nat Rev Mol Cell Biol 10:265-75. 2009
    ..Plks are now recognized to link cell division to developmental processes and to function in differentiated cells. A comparison of Plk function and regulation between organisms offers insight into the rich variations of cell division...
  78. ncbi Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion
    Tom Rolef Ben-Shahar
    Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln sInn Fields, London WC2A 3PX, UK
    Science 321:563-6. 2008
    ..Our results indicate that Eco1 modifies cohesin to stabilize sister chromatid cohesion in parallel with a cohesion establishment reaction that is in principle Eco1-independent...
  79. ncbi Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
    Giles D J Watts
    Division of Genetics, Children s Hospital Boston, 300 Longwood Avenue, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 36:377-81. 2004
    ..Identification of VCP as causing IBMPFD has important implications for other inclusion-body diseases, including myopathies, dementias and Paget disease of bone (PDB), as it may define a new common pathological ubiquitin-based pathway...
  80. ncbi A serum shock induces circadian gene expression in mammalian tissue culture cells
    A Balsalobre
    Departement de Biologie Moleculaire, Sciences II, Universite de Geneve, Switzerland
    Cell 93:929-37. 1998
    ..The serum shock of rat-1 fibroblasts also results in a transient stimulation of c-fos and rper expression and thus mimics light-induced immediate-early gene expression in the suprachiasmatic nucleus...
  81. pmc CBP/p300-mediated acetylation of histone H3 on lysine 56
    Chandrima Das
    Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, PO Box 6511, Aurora Colorado 80045, USA
    Nature 459:113-7. 2009
    ....
  82. pmc A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Genet 41:891-8. 2009
    ....
  83. ncbi Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast
    Jinglan Zhang
    Center for Molecular Discovery, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell 31:143-51. 2008
    ..Our study thus identified a molecular target for the acetyltransferase Eco1 and revealed that Smc3 acetylation is a conserved mechanism in regulating sister chromatid cohesion...
  84. pmc Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis
    Aya Sato
    Howard Hughes Medical Institute, Chevy Chase, MD 20815 USA
    Cell 139:907-19. 2009
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
  85. pmc Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine
    Stefano Santaguida
    Department of Experimental Oncology, European Institute of Oncology, I 20139 Milan, Italy
    J Cell Biol 190:73-87. 2010
    ..They also shed light on the relationship between the error correction pathway and the spindle checkpoint and suggest that these processes are coregulated and are likely to share at least a subset of their catalytic machinery...
  86. ncbi Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
    Yi Tang
    Institute for Cancer Genetics, Surgeons, Columbia University, 1150 St Nicholas Ave, New York, New York 10032, USA
    Mol Cell 24:827-39. 2006
    ....
  87. pmc Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks
    Gareth J Williams
    Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    DNA Repair (Amst) 9:1299-306. 2010
    ....
  88. ncbi A molecular determinant for the establishment of sister chromatid cohesion
    Elcin Unal
    Howard Hughes Medical Institute and Department of Embryology, Carnegie Institution, 3520 San Martin Drive, Baltimore, MD 21218, USA
    Science 321:566-9. 2008
    ..Smc3 head acetylation and its cell cycle regulation provide important insights into the biology and mechanism of cohesion establishment...
  89. ncbi Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery
    Jez G Carlton
    Department of Infectious Diseases, King s College London School of Medicine, London, UK
    Science 316:1908-12. 2007
    ..Thus, HIV-1 budding and cytokinesis use a similar subset of cellular components to carry out topologically similar membrane fission events...
  90. pmc Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
    Masayoshi Yada
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka, Fukuoka, Japan
    EMBO J 23:2116-25. 2004
    ..Accumulation of c-Myc was also apparent in mouse Fbw7-/- embryonic stem cells. These observations suggest that two F-box proteins, Fbw7 and Skp2, differentially regulate c-Myc stability by targeting MB1 and MB2, respectively...
  91. pmc Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
    Kaixin Zhou
    Biomedical Research Institute, University of Dundee, Dundee, UK
    Nat Genet 43:117-20. 2011
    ..We conclude that ATM, a gene known to be involved in DNA repair and cell cycle control, plays a role in the effect of metformin upstream of AMP-activated protein kinase, and variation in this gene alters glycemic response to metformin...
  92. pmc Cohesin: genomic insights into controlling gene transcription and development
    Dale Dorsett
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, United States
    Curr Opin Genet Dev 21:199-206. 2011
    ..These mechanisms are poorly understood, but involve both partial gene repression in concert with Polycomb group proteins, and facilitating long-range looping, both between enhancers and promoters, and between CTCF protein binding sites...
  93. ncbi Sororin mediates sister chromatid cohesion by antagonizing Wapl
    Tomoko Nishiyama
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 143:737-49. 2010
    ..The mechanism we describe here may therefore be widely conserved among different species...
  94. ncbi Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1
    Mark Petronczki
    Cell Division and Aneuploidy Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, United Kingdom
    Dev Cell 14:646-59. 2008
    ..In particular, we highlight new work on the role of Plk1 in cytokinesis in human cells. Finally, we describe how better understanding of Plk1 functions allows critical evaluation of Plk1 as a potential drug target for cancer therapy...
  95. ncbi Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I
    Kirsten P Rabitsch
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Dev Cell 4:535-48. 2003
    ..Csm1 and Pcs1 might clamp together microtubule binding sites on the same (Pcs1) or sister (Csm1) kinetochores...
  96. ncbi Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis
    Hideaki Tagami
    Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cell 116:51-61. 2004
    ..This finding provides new insights into possible mechanisms for maintenance of epigenetic information after chromatin duplication...
  97. pmc Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis
    Fangwei Wang
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Smith Building, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Science 330:231-5. 2010
    ..Therefore, H3T3ph generated by Haspin positions the CPC at centromeres to regulate selected targets of Aurora B during mitosis...
  98. pmc Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
    Sophie E Polo
    Department of Biochemistry, The Gurdon Institute, University of Cambridge, Cambridge, UK
    EMBO J 29:3130-9. 2010
    ..These results provide new insights into how the chromatin remodelling complex NuRD contributes to maintaining genome stability...
  99. ncbi Two histone marks establish the inner centromere and chromosome bi-orientation
    Yuya Yamagishi
    Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113 0032, Japan
    Science 330:239-43. 2010
    ..Haspin colocalizes with cohesin by associating with Pds5, whereas Bub1 localizes at kinetochores. Thus, the inner centromere is defined by intersection of two histone kinases...
  100. pmc p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
    H Christian Reinhardt
    Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E18 580, Cambridge, MA 02139, USA
    Cancer Cell 11:175-89. 2007
    ..We show that the Chk1 inhibitor UCN-01 also potently inhibits MK2, suggesting that its clinical efficacy results from the simultaneous disruption of two critical checkpoint pathways in p53-defective cells...
  101. ncbi Visualizing spatiotemporal dynamics of multicellular cell-cycle progression
    Asako Sakaue-Sawano
    Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    Cell 132:487-98. 2008
    ..These mice and cell lines will serve as model systems permitting unprecedented spatial and temporal resolution to help us better understand how the cell cycle is coordinated with various biological events...

Research Grants62

  1. ARGINASE AND ARTERIAL INJURY
    William Durante; Fiscal Year: 2009
    ..In addition, the effect of arginase I on cell cycle proteins will be explored...
  2. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    ..After cerebral ischemia, expressions of cell cycle proteins are altered...
  3. Cell Cycle Pathways and Spinal Cord Injury
    ALAN IRA FADEN; Fiscal Year: 2011
    ..Upregulation of cell cycle proteins occurs after central nervous system (CMS) trauma, and appears to contribute to apoptotic cell death of post-..
  4. Molecular mechanisms of C/EBP alpha mediated growth arrest
    Nikolai A Timchenko; Fiscal Year: 2013
    ..ability of C/EBP1 to inhibit cell proliferation mainly depends on the direct interactions of C/EBP1 with cell cycle proteins and these interactions are controlled by certain signal transduction pathways such as cyclin D3-cdk4/6 and ..
  5. Receptor/Ligand Signals for Ovarian Follicular Angiogenesis
    Leon J Spicer; Fiscal Year: 2010
    ....
  6. Role of Cyclins in Brain Construction and Interneuron Genesis
    KRISTIN GIAMANCO; Fiscal Year: 2013
    ..construction we will compare and contrast the actions of G1-phase cyclin D2 (cD2) versus cyclin D1 (cD1), cell cycle proteins that regulate passage through mid-G1 toward S-phase...
  7. Genetics and Biology of CIZ1 in Cervical Dystonia
    Mark S Ledoux; Fiscal Year: 2013
    ....
  8. B-RAF Regulation of the Cell Cycle in Melanoma
    Andrew E Aplin; Fiscal Year: 2013
    ..signaling in human melanoma cells elevates activation of the MEK-ERK1/2 pathway and regulates two key G1 cell cycle proteins: cyclin D1 and p27Kip1...
  9. Mechanistic regulation of tumor specific forms of cyclin E in breast cancer
    NIKKI A DELK; Fiscal Year: 2010
    ..Therefore, understanding the mechanisms that govern the regulation of cell cycle proteins is integral to developing treatment strategies that specifically target tumor cells...
  10. Cell Cycle and Podocytes
    STUART JAMES SHANKLAND; Fiscal Year: 2013
    ..The focus will remain on how specific cell cycle proteins regulate glomerular cells in health, and in disease...
  11. Understanding the Biological Function of MCM 10
    Anja Katrin Bielinsky; Fiscal Year: 2013
    ..Lessons learnt from simple organisms will be applied to the human system to understand the molecular pathways of cancer. ..
  12. CELLULAR AND MOLECULAR MECHANISMS OF GASTROINTESTINAL CANCERS
    Lopa Mishra; Fiscal Year: 2013
    ..L. Mishra, utilizing a mouse model system, plans to find out how cross talk between TGF-beta signaling and cell cycle proteins (CDK4) and the E3 ligase PRAJA modulate foregut tumor suppression and to determine the potential role of ..
  13. Hepatitis B Virus X protein and Alcohol Regulation of Cell Cycle Progression
    TRICIA LEIGH GEARHART; Fiscal Year: 2010
    ..effects of HBx, HBV and ethanol on cell cycle progression by examining cell proliferation and regulation of cell cycle proteins, (2) we will assay the effect of ethanol exposure and cell cycle progression on HBV replication and explore ..
  14. Thyroid regulation of cardiomyocyte maturation
    KENT L R THORNBURG; Fiscal Year: 2013
    ..of T3 will be evaluated by measuring the activation levels of ERK, AKT, mTOR and p70S6K, as well as key cell cycle proteins. "Non-genomic" pathways will also be evaluated...
  15. ROLE OF CELL CYCLE PROTEINS IN HIV ENCEPHALITIS
    KELLY L JORDANSCIUTTO; Fiscal Year: 2013
    ..Given its potentially unique function and regulation in post-mitotic neurons, we believe E2F1 may serve as a target to prevent neuronal loss in HIV associated dementia. ..
  16. Role of Cell Cycle in Neurodegeneration
    Hyoung gon Lee; Fiscal Year: 2012
    ..mechanism may play an important role in disease pathogenesis is highlighted by the earlier occurrence of cell cycle proteins compared to abnormal tau in AD and by their appearance at the very earliest prodrominal phase of disease (i...
  17. The Role of MicroRNAs in Controlling Fibroblast Proliferation and Tumor Promotion
    Aster Legesse-Miller; Fiscal Year: 2013
    ..Low let-7 levels may result in high levels of Cdc34, leading to more rapid proteolysis of cell cycle proteins and ultimately making cells prone to chromosomal instability, with resultant cancerous growth...
  18. Structure and Function of the Exocyst Complex
    Mary Munson; Fiscal Year: 2013
    ..of exocytosis;physical tethering of secretory vesicles to these sites;communicating with cytoskeletal and cell cycle proteins;and regulating the specificity and assembly of the SNARE proteins...
  19. Novel regulatory mechanisms of Drosophila Pumilio and Nanos
    AARON CHARLES GOLDSTROHM; Fiscal Year: 2013
    ..Pum binds an extensive group of messenger RNAs including those that encode cell cycle proteins and key developmental morphogens. Upon binding to an mRNA, Pum represses expression of the encoded protein...
  20. Regulation of Cellular Growth and Division by Ubiquitin-Mediated Proteolysis
    Jennifer A Benanti; Fiscal Year: 2012
    ..In the experiments proposed here, we will determine the mechanism of turnover of these cell cycle proteins by specific E3s, and examine the importance of these turnover events for nonnal cell cycle progression...
  21. Role of LIN-9 in Mammalian Cell Cycle Regulation
    Raudel Sandoval; Fiscal Year: 2011
    ..stability of this complex temporally along the cell cycle and examine the potential interaction with other cell cycle proteins. Changes of this complex along different phases of the cell cycle will help us to better understand the ..
  22. Breast cancer prognostic factors/pathobiology
    Kathleen Malone; Fiscal Year: 2009
    ..factors and tumor markers, including both well characterized prognostic markers and less well-characterized cell cycle proteins, with the risk of dying from breast cancer, (4) to build tissue microarrays that will allow rapid ..
  23. Mechanisms that coordinate cell size with mitotic entry
    James B Moseley; Fiscal Year: 2013
    ..by identifying the mechanisms that coordinate cell growth and division through the activity of core cell cycle proteins. Moreover, the sizing mechanisms that we uncover will provide insights for how size controls the activity ..
  24. CELL CYCLE PROTEINS IN RENAL GROWTH, INJURY, AND REPAIR
    PATRICIA PREISIG; Fiscal Year: 2004
    ..Aim 1 will continue to characterize the role of cell cycle proteins in compensatory renal growth. Aim 2 will focus of diabetes-induced hypertrophy...
  25. PEROXISOME PROLIFERATOR INDUCED HEPATOCARCINOGENESIS
    Sambasiva Rao; Fiscal Year: 2004
    ..resulting from deficiency of dietary factors, and 5) evaluation of the role of growth factors and cell cycle proteins in hepatocarcinogenesis induced by dietary factors and ciprofibrate in rats and spontaneous tumors in AOX ..
  26. Is thyroid hormone a key regulator of fetal cardiomyocyte proliferation?
    Kent Thornburg; Fiscal Year: 2009
    ..Expression levels of deiodinases and thyroid receptors will also be measured;levels of key cell cycle proteins will be analyzed by western blot...
  27. Immunotoxicology of Cigarette Smoke
    Brian Freed; Fiscal Year: 2007
    ..Analysis of cell cycle proteins (Myc, Cdk4, Cdk6, cyclins, E2F4, p130) will be performed by flow cytometry, immunoprecipitation and western ..
  28. MOLECULAR CHARACTERIZATION OF MCLI PCNA INTERACTION
    Kenichi Fujise; Fiscal Year: 2003
    ..The MCL1-PCNA interaction may be an important molecular link between anti-apoptotic proteins and cell cycle proteins. Based on the hypothesis that MCL1 plays a role in DNA repair and replication and cell proliferation and ..
  29. ADHESION MOLECULES IN SMOOTH MUSCLE ACTIVATION & GROWTH
    AILI LAZAAR; Fiscal Year: 2003
    ..incorporation of 3H-leucine, effects on smooth muscle cell-specific gene expression, and expression of cell cycle proteins. In Aim 2, the applicant will determine whether IgSF-induced activation of PI3K and p70S6K modulates ..
  30. Role of ornithine decarboxylase in Ras transformation
    Lisa Shantz; Fiscal Year: 2006
    ..We will examine tumors from MEK/AZ mice to determine effects on cell cycle proteins, apoptosis, and proliferation...
  31. Clinical Activity of 17-AAG in Lymphoma
    Anas Younes; Fiscal Year: 2007
    ..our preliminary data demonstrated that 17-AAG decreased lymphoma cellular contents of critical survival and cell cycle proteins including AKT, ERK, and cyclin D1; and activated the intrinsic caspase pathway...
  32. Signaling Pathways in Hepatic Fibrogenesis
    Bruce Bacon; Fiscal Year: 2005
    ..Since activated HSC play a key role in hepatic fibrogenesis, these experiments will contribute to an improved understanding of the basic biochemical processes underlying hepatic fibrosis. ..
  33. E2F-mediated Control of Vascular Growth and Remodeling
    Bruce Sullenger; Fiscal Year: 2006
    ..studies have attempted to limit VSMC proliferation and intimal hyperplasia by delivering inhibitors of cell cycle proteins to by-pass grafts or sites of angioplasty...
  34. Increasing Functional Liver Mass in Health and Disease
    Leonidas Koniaris; Fiscal Year: 2005
    ..Once injured, however, many complex cascades of growth factors, signaling molecules and cell cycle proteins orchestrate the coordinated exit of hepatocytes from growth arrest (GO), into the cell cycle (G1), DNA ..
  35. Role of a novel oncogene in mesothelioma
    Alice Boylan; Fiscal Year: 2007
    ..Focus will be placed upon the role of CaSm in regulation of expression of cell cycle proteins. Actinomycin chase and mutation analysis experiments will then be performed to determine if CaSm exerts its ..
  36. Therapy of Melanoma with Bortezomib and Interferon-alpha
    William Carson; Fiscal Year: 2007
    ..leads to growth arrest and apoptotic cell death via multiple mechanisms including altered turnover of cell cycle proteins and blockade of pro-survival signals...
  37. Interaction between HIV-1 and cell cycle proteins
    Antonio Giordano; Fiscal Year: 2003
    ..In particular, we will focus our attention on the cell cycle regulatory proteins, pRb2/pl30, Cdk9 and cycT1, which seem to be involved in AIDS-related tumorigenesis. ..
  38. ROLE OF PGE2 RECEPTORS EP2 AND EP3 ON SENESCENCE
    Raymond Konger; Fiscal Year: 2004
    ..interventions, how do EP2 and EP3 intracellular signaling pathways integrate with the expression of the key cell cycle proteins, p21WAF1, telomerase, and p161NK4A? 4...
  39. Transcriptional Responses in Neurodegenerative Diseases
    Robert Bowser; Fiscal Year: 2007
    ..Specific drugs that affect cell cycle proteins will be examined for their ability to slow disease onset and increase survival in this animal model...
  40. OPTIMA XL-A ANALYTICAL ULTRACENTRIFUGE SYSTEM
    Marc Kirschner; Fiscal Year: 1992
    ..users listed on the grant are Marc Kirschner, whose project is entitled "Oligomerization of Tubulins and Cell Cycle Proteins;" Bruce Alberts ("Isolation and Characterization of Multiprotein Complexes"); Tim Mitchison ("Microtubule ..
  41. REGULATION OF CORNEAL CELL PROLIFERATION
    Ian Rawe; Fiscal Year: 2003
    ..The second objective is to determine the cell cycle proteins that are regulated by these specific protein kinase C isoforms...
  42. ION CHANNELS IN DEMYELINATING DISEASES
    Betty Soliven; Fiscal Year: 2003
    ..depending on the nature of concomitant signals; and 2) Ik is required for sequential activation of cell cycle proteins and regulation of mitogen-activated protein kinases...
  43. TERMINAL DIFFERENTIATION OF GROWTH PLATE CHONDROCYTES
    R Ballock; Fiscal Year: 2001
    ..response to thyroid hormone-induced terminal differentiation in this system; and 3) to overexpress specific cell cycle proteins in growth plate chondrocytes, by transient transfection, to determine their effect on thyroid hormone ..
  44. CELLULAR MECHANISMS OF PTLD IN TRANSPLANT RECIPIENTS
    OLIVIA MARTINEZ; Fiscal Year: 2002
    ..the mechanism by which RAPA inhibits growth of EBV-infected B cells with specific focus on apoptosis, cell cycle proteins and the JakISTAT pathway...
  45. Cell cycle regulation of pulmonary vascular remodeling
    Brian Fouty; Fiscal Year: 2007
    ..cyclin-dependent kinase inhibitor- (p21Cip1/Waf1 and p27Kip1) deficient animals we will examine: 1) how G1 cell cycle proteins are regulated in 'proliferative' compared to 'non-proliferative' PA SMC following ..
  46. PHENYLBUTYRATE BIOACTIVITY ASSESSMENT IN PROSTATE CANCER
    Michael Carducci; Fiscal Year: 2000
    ..VEGF, ET-1), changes in prostate specific membrane antigen expression (PSMA, PSA), and the induction of cell cycle proteins associated with differentiation or growth arrest (p2lwaf1/cip, cyclin D1) in patients after phenylbutyrate ..
  47. PROTEIN SEQUENCER AND HPLC
    DANIEL MARSHAK; Fiscal Year: 1992
    ..cell growth and differentiation; and 6) the identification and characterization of signal transduction and cell cycle proteins detected on high resolution, two-dimensional gels...
  48. GENE TRANSFER IN MODELS OF ARTERIAL INJURY
    Robert Simari; Fiscal Year: 2000
    ..We hypothesize that intimal cell growth and thrombosis are regulated by cell cycle proteins and prothrombotic proteins, respectively...
  49. MECHANISMS OF ID2-ENHANCED VASCULAR SMOOTH MUSCLE GROWTH
    Martin Matsumura; Fiscal Year: 2001
    ..in an Id2-/- background will be determined using histological assessment of proliferation, apoptosis, and expression of cell cycle proteins that were demonstrated to interact with or be regulated by Id2 in aims 1 and 2.
  50. RENAL RESPONSE TO INJURY
    William Couser; Fiscal Year: 2002
    ..In Project 1, Dr. Roberts will explore the role of several cell cycle proteins in regulatory cell growth, and in Project 2 Dr...
  51. Role of Cell Cycle Proteins in Apoptosis
    CHRISTINE LOGAR; Fiscal Year: 2006
    ..CDK-inhibitors bind to and inactivate CDKs. In this grant proposal we will show that cell cycle proteins have a critical role in regulating cell apoptosis, independent of proliferation...
  52. CELL CYCLE REGULATION DURING GLIAL DEVELOPMENT
    RAVINDER TIKOO; Fiscal Year: 2001
    ..This cell differentiates into an astrocyte or an oligodendrocyte, depending on the culture conditions. The cell cycle proteins,known to be important in regulating cellular proliferation, are being examined for their role in glial ..
  53. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    MARJORIE MONTANEZ WISCOVICH; Fiscal Year: 2007
    ..Further studies in our laboratory suggest that LMO4 is involved in regulation of cell cycle proteins. Prompted by these data, we hypothesize that LMO4 is necessary for ErbB2 tumor properties via a mechanism ..
  54. INITIAL STEPS IN RAAV TRANSDUCTION
    Matthew Weitzman; Fiscal Year: 2003
    ..We have linked E4orf6 to cell cycle proteins and generated a mutant that is selectively incapable to enhancing rAAV...
  55. GENETIC ALTERATIONS IN CNS TUMOR DEVELOPMENT
    Charles James; Fiscal Year: 1999
    ..Analysis of expression and biological effects of cell cycle proteins will contribute towards the development of a detailed and precise description of the fundamental mechanisms ..
  56. MOLECULAR GENETICS OF LENS AND CATARACT DEVELOPMENT
    Ronald DePinho; Fiscal Year: 2000
    ..studies will further understanding of the role of Myc family proteins as key regulators through their association with cell cycle proteins and their transactivation of target genes controlling lens proliferation and differentiation.
  57. CELL CYCLE CONTROL IN GLOMERULAR DISEASE
    Stuart Shankland; Fiscal Year: 2007
    ..cycle by positive (cyclins and cyclin-dependent kinases) and negative (cyclin-dependent kinase inhibitors) cell cycle proteins. Recent evidence shows that cell cycle proteins are in turn controlled by other events, such as DNA damage...
  58. MECHANISMS OF PODOCYTE INJURY
    Stuart Shankland; Fiscal Year: 2005
    ..aim we will test the hypothesis that cyclin I and cyclin-dependent kinase (CDK) 5, recently identified cell cycle proteins, regulate podo proliferation and differentiation...
  59. 7th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2008
    ..In summary, the only hope for our patients is by focused and concerted efforts such as the 7th International Podocyte Conference which will ultimately enhance their overall care. [unreadable] [unreadable] [unreadable]..
  60. 5TH INTERNATIONAL PODOCYTE CONFERENCE
    Stuart Shankland; Fiscal Year: 2004
    ..3. To facilitate cross-talk between clinicians and scientists with the ultimate goal of improving prognosis, treatment and care of patients with glomerular disease. ..
  61. 6th International Podocyte Conference
    Stuart Shankland; Fiscal Year: 2006
    ..Moreover, this is an exciting era in podocytes biology given the large body of literature that has been published in the past 2-5 years. [unreadable] [unreadable] [unreadable]..
  62. ATM and DNA Damage in the Nervous System
    PETER MCKINNON; Fiscal Year: 2007
    ..abstract_text> ..