sex hormone binding globulin

Summary

Summary: A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.

Top Publications

  1. ncbi Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 27:1036-41. 2004
  2. ncbi Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men
    Nelly Pitteloud
    Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:2636-41. 2005
  3. ncbi Plasma sex hormone concentrations and subsequent risk of breast cancer among women using postmenopausal hormones
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 97:595-602. 2005
  4. ncbi Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis
    Eric L Ding
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    JAMA 295:1288-99. 2006
  5. ncbi Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans
    Sabine Rohrmann
    Division of Cancer Epidemiology, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 92:2519-25. 2007
  6. ncbi Endogenous sex hormones and metabolic syndrome in aging men
    Majon Muller
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, Room D 01 335, 3508 GA Utrecht, The Netherlands
    J Clin Endocrinol Metab 90:2618-23. 2005
  7. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
  8. ncbi The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromsø Study
    Johan Svartberg
    Department of Medicine, University Hospital of North Norway, N 9038, Tromsø, Norway
    Eur J Endocrinol 149:145-52. 2003
  9. ncbi Aging, androgens, and the metabolic syndrome in a longitudinal study of aging
    Annabelle Rodriguez
    Department of Medicine, Division of Endocrinology, Johns Hopkins Bayview Medical Center, B Building, Suite 114, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 92:3568-72. 2007
  10. ncbi Exposure to CB-153 and p,p'-DDE and male reproductive function
    A Rignell-Hydbom
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Hum Reprod 19:2066-75. 2004

Detail Information

Publications229 found, 100 shown here

  1. ncbi Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 27:1036-41. 2004
    ..We assessed the association of low levels of testosterone and sex hormone-binding globulin (SHBG) with the development of the metabolic syndrome and diabetes in men...
  2. ncbi Increasing insulin resistance is associated with a decrease in Leydig cell testosterone secretion in men
    Nelly Pitteloud
    Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:2636-41. 2005
    ..05). From these data we conclude that insulin resistance is associated with a decrease in Leydig cell T secretion in men. Additional studies are required to determine the mechanism of this effect...
  3. ncbi Plasma sex hormone concentrations and subsequent risk of breast cancer among women using postmenopausal hormones
    Shelley S Tworoger
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 97:595-602. 2005
    ....
  4. ncbi Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis
    Eric L Ding
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    JAMA 295:1288-99. 2006
    ..Inconsistent data suggest that endogenous sex hormones may have a role in sex-dependent etiologies of type 2 diabetes, such that hyperandrogenism may increase risk in women while decreasing risk in men...
  5. ncbi Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans
    Sabine Rohrmann
    Division of Cancer Epidemiology, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Clin Endocrinol Metab 92:2519-25. 2007
    ..Previous studies comparing hormone levels by race might have been limited by size, restricted age variation, or lack of representation of the general population...
  6. ncbi Endogenous sex hormones and metabolic syndrome in aging men
    Majon Muller
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, Room D 01 335, 3508 GA Utrecht, The Netherlands
    J Clin Endocrinol Metab 90:2618-23. 2005
    ..Sex hormone levels in men change during aging. These changes may be associated with insulin sensitivity and the metabolic syndrome...
  7. ncbi Polymorphisms associated with circulating sex hormone levels in postmenopausal women
    Alison M Dunning
    Cancer Research UK, Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
    J Natl Cancer Inst 96:936-45. 2004
    ..We investigated the association between levels of sex hormones and single nucleotide polymorphisms (SNPs) in genes coding for the enzymes that regulate them...
  8. ncbi The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromsø Study
    Johan Svartberg
    Department of Medicine, University Hospital of North Norway, N 9038, Tromsø, Norway
    Eur J Endocrinol 149:145-52. 2003
    ....
  9. ncbi Aging, androgens, and the metabolic syndrome in a longitudinal study of aging
    Annabelle Rodriguez
    Department of Medicine, Division of Endocrinology, Johns Hopkins Bayview Medical Center, B Building, Suite 114, 4940 Eastern Avenue, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 92:3568-72. 2007
    ..The aim of this study was to evaluate the relationship between the MS and circulating androgen levels in a cohort of men in the Baltimore Longitudinal Study of Aging...
  10. ncbi Exposure to CB-153 and p,p'-DDE and male reproductive function
    A Rignell-Hydbom
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Hum Reprod 19:2066-75. 2004
    ....
  11. ncbi Age-related changes in serum testosterone and sex hormone binding globulin in Australian men: longitudinal analyses of two geographically separate regional cohorts
    Peter Y Liu
    Department of Andrology, Concord Hospital and ANZAC Research Institute, University of Sydney, Sydney, New South Wales 2139, Australia
    J Clin Endocrinol Metab 92:3599-603. 2007
    ..Cross-sectional studies from different populations show a variable decline in blood testosterone concentrations as men age. Few population representative cohorts have been followed up over time...
  12. pmc The effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men
    Erin S LeBlanc
    Bone and Mineral Unit, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    J Clin Endocrinol Metab 94:3337-46. 2009
    ..The relationship between sex steroids and fracture is poorly understood...
  13. ncbi Association of bioavailable, free, and total testosterone with insulin resistance: influence of sex hormone-binding globulin and body fat
    Elaine C Tsai
    Veterans Affairs Puget Sound Health Care System and the University of Washington, Seattle, Washington 98108, USA
    Diabetes Care 27:861-8. 2004
    ....
  14. pmc Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups
    Varant Kupelian
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 93:3403-10. 2008
    ..Low sex hormone levels have been associated with the metabolic syndrome (MetS)...
  15. ncbi Estradiol induction of cAMP in breast cancer cells is mediated by foetal calf serum (FCS) and sex hormone-binding globulin (SHBG)
    N Fortunati
    Laboratorio di Endocrinologia, II UO ADU Medicina Generale, Azienda Ospedaliera S Giovanni B ta and Dip Fisiopatologia Clinica, Universita di Torino, Italy
    J Steroid Biochem Mol Biol 70:73-80. 1999
    ..SHBG is one of the serum factors mediating estradiol action. Lastly, it was proven that SHBG triggers the cAMP pathway in MCF-7 cells in a physiologic culture condition and at physiologic concentrations...
  16. ncbi A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density
    G Rannevik
    Department of Obstetrics and Gynecology, University of Lund, , Sweden
    Maturitas 21:103-13. 1995
    ..The impact of this will influence the severity of symptoms, the degree of bone loss and the need for supplementary therapy...
  17. ncbi Associations between reproductive and menstrual factors and postmenopausal sex hormone concentrations
    Jessica Chubak
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, P O Box 19024, M4 B402, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 13:1296-301. 2004
    ..menstrual/reproductive factors and serum concentrations of free estradiol, total estradiol, estrone, sex hormone binding globulin (SHBG), and follicle stimulating hormone (FSH)...
  18. ncbi Clinical and biochemical assessment of hypogonadism in men with type 2 diabetes: correlations with bioavailable testosterone and visceral adiposity
    Dheeraj Kapoor
    The Robert Hague Centre for Diabetes and Endocrinology, Barnsley Hospital NHS Foundation Trust, Barnsley, UK
    Diabetes Care 30:911-7. 2007
    ..The aim of our study was to assess the prevalence of clinical hypogonadism, based on both symptoms and biochemical available measures of testosterone deficiency, in men with type 2 diabetes...
  19. pmc Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    Eric L Ding
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 361:1152-63. 2009
    ..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain...
  20. ncbi Serum concentrations of sex hormone binding globulin are elevated in kwashiorkor and anorexia nervosa but not in marasmus
    Nathalie Pascal
    Laboratoire de Pathologie Cellulaire et Moleculaire en Nutrition, EMI INSERM 0014 et URM IFREMER 20, Faculte de Medecine, Vandoeuvre, France
    Am J Clin Nutr 76:239-44. 2002
    ..Customary blood protein markers for malnutrition are of limited value in the diagnosis of protein-energy malnutrition or anorexia nervosa in children and in the follow-up to refeeding in such children...
  21. pmc Sex hormone binding globulin and incident Alzheimer's disease in elderly men and women
    Majon Muller
    Department of Geriatric Medicine, University Medical Center, Utrecht, The Netherlands
    Neurobiol Aging 31:1758-65. 2010
    ..Whether SHBG is causally related to dementia or whether it is a surrogate marker for rate of biological aging and increased risk or for preclinical stage of dementia has to be elucidated...
  22. ncbi Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC)
    Rudolf Kaaks
    Nutrition and Hormones Group, International Agency for Research on Cancer IARC WHO, Lyon, France
    J Natl Cancer Inst 97:755-65. 2005
    ..We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort to examine associations among premenopausal serum concentrations of sex steroids and subsequent breast cancer risk...
  23. pmc Correlations between serum testosterone, estradiol, and sex hormone-binding globulin and bone mineral density in a diverse sample of men
    Andre B Araujo
    New England Research Institutes, 9 Galen Street, Watertown, MA 02472, USA
    J Clin Endocrinol Metab 93:2135-41. 2008
    ..However, most studies have been conducted in homogenous populations, and it is not known whether differences in hormones impact racial and ethnic differences in BMD...
  24. ncbi Variant in sex hormone-binding globulin gene and the risk of prostate cancer
    Sonja I Berndt
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7240, USA
    Cancer Epidemiol Biomarkers Prev 16:165-8. 2007
    ..34; 95% confidence interval, 1.10-1.63; P = 0.0007). This study suggests that genetic variation in SHBG may influence prostate cancer susceptibility...
  25. ncbi Validity of free testosterone and free estradiol determinations in serum samples from postmenopausal women by theoretical calculations
    Sabina Rinaldi
    IARC, Unit of Nutrition and Cancer, 69500 Lyon, France
    Cancer Epidemiol Biomarkers Prev 11:1065-71. 2002
    ....
  26. pmc Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes
    John R B Perry
    Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Magdalen Road, Exeter, UK
    Hum Mol Genet 19:535-44. 2010
    Epidemiological studies consistently show that circulating sex hormone binding globulin (SHBG) levels are lower in type 2 diabetes patients than non-diabetic individuals, but the causal nature of this association is controversial...
  27. ncbi Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies
    T Key
    Cancer Research U K Epidemiology Unit, University of Oxford, Radcliffe Infirmary, Oxford, UK
    J Natl Cancer Inst 94:606-16. 2002
    ..We reanalyzed the worldwide data from prospective studies to examine the relationship between the levels of endogenous sex hormones and breast cancer risk in postmenopausal women...
  28. ncbi Can changes in sex hormone binding globulin predict the risk of venous thromboembolism with combined oral contraceptive pills?
    Viveca Odlind
    Department of Obstetrics and Gynecology, Karolinska Hospital, Stockholm, Sweden
    Acta Obstet Gynecol Scand 81:482-90. 2002
    ..The aim of this article is to discuss sex hormone binding globulin (SHBG) as a marker of estrogenicity and as a surrogate indicator for the potential risk of VTE in users ..
  29. ncbi Relationship between BMI, total testosterone, sex hormone-binding-globulin, leptin, insulin and insulin resistance in obese men
    J A Osuna
    Unidad de Endocrinologia, Instituto Autónomo Hospital Universitario de Los Andes, Laboratorio de Andrologia, Centro de Microscopia Electronica, Escuela de Medicina, Universidad de Los Andes, Merida, Venezuela
    Arch Androl 52:355-61. 2006
    ..313; p < 0.01) and insulin resistance (= -0.266; p < 0.05). Our results shows that in a sample of men, Tt and SHBG concentrations proportionally diminished with both the increase of BMI and insulin resistance index...
  30. ncbi First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus
    Ravi Thadhani
    Departments of Medicine and Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Obstet Gynecol 189:171-6. 2003
    We sought to examine the association between early pregnancy levels of sex hormone binding globulin and subsequent gestational diabetes mellitus, an association that has not been studied previously.
  31. ncbi Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort
    Christopher A Haiman
    University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, California 90089, USA
    J Clin Endocrinol Metab 90:2198-204. 2005
    ....
  32. ncbi Testosterone and oestradiol in relation to tobacco smoking, body mass index, energy consumption and nutrient intake among adult men
    R Tamimi
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Eur J Cancer Prev 10:275-80. 2001
    ..Serologic measurements of oestradiol, testosterone and sex hormone binding globulin were also conducted...
  33. ncbi Low sex hormone binding globulin is a potential marker for the metabolic syndrome in different ethnic groups
    A H Heald
    Department of Endocrinology, University of Manchester, Salford NHS Trust, Salford, UK
    Exp Clin Endocrinol Diabetes 113:522-8. 2005
    ..As ethnic differences in SHBG level closely parallel differences in insulin resistance. Its measurement may be useful in identifying individuals at particular risk of the metabolic syndrome, for early intervention...
  34. ncbi Lower sex hormone-binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men: the Health in Men Study
    S A Paul Chubb
    PathWest, Department of Biochemistry, Fremantle Hospital, Western Australia, 6160 Australia
    Eur J Endocrinol 158:785-92. 2008
    ..As SHBG increases with age while testosterone declines, we examined the relative contributions of SHBG and testosterone to the risk of metabolic syndrome in older men...
  35. ncbi Association of endometrial cancer risk with a functional polymorphism (Asp(327)Asn) in the sex hormone-binding globulin gene
    Nobuhiko Kataoka
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
    Cancer 109:1296-302. 2007
    ....
  36. ncbi Associations of adiponectin with sex hormone-binding globulin levels in aging male and female populations
    Toshiyuki Yasui
    Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
    Clin Chim Acta 386:69-75. 2007
    ..We examined the relationships of serum adiponectin concentrations with serum concentrations of hormones and SHBG in men and women...
  37. pmc Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene
    David M Selva
    Department of Obstetrics and Gynecology, University of British Columbia, Child and Family Research Institute, Vancouver, British Columbia, Canada
    J Clin Invest 117:3979-87. 2007
    ..This provides a biological explanation for why SHBG is a sensitive biomarker of the metabolic syndrome and the metabolic disturbances associated with increased fructose consumption...
  38. ncbi Changes in BMI modulate age-associated changes in sex hormone binding globulin and total testosterone, but not bioavailable testosterone in young adult men: the CARDIA Male Hormone Study
    S M Gapstur
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Int J Obes (Lond) 31:685-91. 2007
    To compare age-associated 8-year changes in total testosterone, calculated bioavailable testosterone and sex hormone binding globulin (SHBG) across five groups of men stratified according to change in body mass index (BMI) (i.e...
  39. ncbi Determination of bioavailable testosterone [non sex hormone binding globulin (SHBG)-bound testosterone] in a population of healthy French men: influence of androstenediol on testosterone binding to SHBG
    Frank Giton
    Assistance Publique Hopitaux de Paris AP HP, Biological Center of Investigations, University Hospital Group, Sud Henri Mondor, Faculte de Medecine, Creteil, France
    Clin Chem 53:2160-8. 2007
    ..The cBT depends, however, on the values of the association constants of total testosterone (TT) for sex hormone-binding globulin (SHBG; K(s)) and albumin (K(a)), and its use therefore remains controversial...
  40. ncbi Osteoporosis in men: a potential role for the sex hormone binding globulin
    E Legrand
    Service de Rhumatologie, Centre Hospitalier Universitaire, Angers, France
    Bone 29:90-5. 2001
    ..It has been suggested that estrogen and sex hormone binding globulin (SHBG) play a role in regulating bone turnover and bone mass in healthy men > 65 years of age...
  41. pmc Genetic polymorphisms are associated with serum levels of sex hormone binding globulin in postmenopausal women
    Jose A Riancho
    Department of Internal Medicine, Hospital UM Valdecilla IFIMAV, University of Cantabria, Santander, Spain
    BMC Med Genet 9:112. 2008
    Estrogen activity plays a critical role in bone homeostasis. The serum levels of sex hormone binding globulin (SHBG) influence free estrogen levels and activity on target tissues...
  42. pmc Sex hormone binding globulin levels across the adult lifespan in women--the role of body mass index and fasting insulin
    M Maggio
    Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, School of Endocrinology, University of Parma, Parma, Italy
    J Endocrinol Invest 31:597-601. 2008
    ..00039 to 0.00028). SHBG levels show an age-related U-shaped trajectory. These changes mirror the age-related changes in BMI and fasting insulin, suggesting that BMI and insulin negatively influence SHBG concentration...
  43. ncbi Alcohol and endogenous sex steroid levels in postmenopausal women: a cross-sectional study
    N Charlotte Onland-Moret
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Room Str 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Clin Endocrinol Metab 90:1414-9. 2005
    ..This finding supports the hypothesis that alcohol use may increase breast cancer risk at least partially through an effect on sex steroid levels...
  44. ncbi Steroid conjugates of dichloro(6-aminomethylnicotinate)platinum(II): effects on DNA, sex hormone binding globulin, the estrogen receptor, and various breast cancer cell lines
    Rainer Schobert
    Organisch chemisches Laboratorium der Universität, 95447 Bayreuth, Germany
    ChemMedChem 2:333-42. 2007
    ..Their affinities towards sex hormone binding globulin (SHBG) and towards the nuclear estrogen receptor ER(alpha) were assessed by competitive displacement ..
  45. ncbi Identification and measurement of sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) in human saliva
    G L Hammond
    Acta Endocrinol (Copenh) 112:603-8. 1986
    b>Sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) were detected by specific immunoassays in mixed-saliva taken from normal men and women...
  46. ncbi Estetrol does not bind sex hormone binding globulin or increase its production by human HepG2 cells
    G L Hammond
    Department of Obstetrics and Gynecology, University of British Columbia, and Child and Family Research Institute, Vancouver, Canada
    Climacteric 11:41-6. 2008
    To determine whether human sex hormone binding globulin (SHBG) binds estetrol (E4), and to assess whether E4 stimulates the production of SHBG by human hepatocytes.
  47. ncbi Sea bass (Dicentrarchus labrax) sex hormone binding globulin: molecular and biochemical properties and phylogenetic comparison of its orthologues in multiple fish species
    Solange Miguel-Queralt
    Department of Obstetrics and Gynaecology, University of British Columbia, BC, Canada
    Mol Cell Endocrinol 229:21-9. 2005
    b>Sex hormone binding globulin (SHBG) binds and transports androgens and estrogens in the blood of vertebrate species including fish...
  48. ncbi Identification of sex hormone binding globulin-interacting proteins in the brain using phage display screening
    M Gnanasekar
    Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, IL 61107, USA
    Int J Mol Med 24:421-6. 2009
    The present study reports the identification of human sex hormone binding globulin (SHBG)-interacting proteins in the brain using a phage display-based screening technology...
  49. ncbi Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men
    Nelly Pitteloud
    Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes Care 28:1636-42. 2005
    ..The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men...
  50. ncbi Sex-hormone-binding globulin and the free androgen index are related to cardiovascular risk factors in multiethnic premenopausal and perimenopausal women enrolled in the Study of Women Across the Nation (SWAN)
    Kim Sutton-Tyrrell
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 127 Parran Hall 130 DeSoto St, Pittsburgh, PA 15261, USA
    Circulation 111:1242-9. 2005
    ..Recent clinical trials have shifted attention away from estrogens and toward androgens and sex hormone-binding globulin (SHBG) as potential mediators of increasing cardiovascular (CV) risk in women at midlife...
  51. ncbi Androgens and diabetes in men: results from the Third National Health and Nutrition Examination Survey (NHANES III)
    Elizabeth Selvin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Diabetes Care 30:234-8. 2007
    ..The objective of this study is to test the hypothesis that low normal levels of total, free, and bioavailable testosterone are associated with prevalent diabetes in men...
  52. ncbi A mathematical comparison of techniques to predict biologically available testosterone in a cohort of 1072 men
    Paul D Morris
    Department of Cardiology, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Eur J Endocrinol 151:241-9. 2004
    ..We compared the efficacy of calculated markers of androgen status in predicting serum BioT and hypogonadism...
  53. ncbi Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men
    Varant Kupelian
    New England Research Institutes, 9 Galen Street, Watertown, Massachusetts 02472, USA
    J Clin Endocrinol Metab 91:843-50. 2006
    ..The purpose of this analysis was to determine whether low serum sex hormone levels or clinical androgen deficiency (AD) predict the development of MetS...
  54. ncbi Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women
    A Heather Eliassen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    J Natl Cancer Inst 98:1406-15. 2006
    ..We prospectively evaluated associations between plasma sex hormone levels and breast cancer risk among premenopausal women in a case-control study nested within the Nurses' Health Study II...
  55. ncbi Endogenous sex hormones, sex hormone-binding globulin, and the risk of incident vertebral fractures in elderly men and women: the Rotterdam Study
    Hermien W Goderie-Plomp
    Department of Internal Medicine, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:3261-9. 2004
    ..For men, no clear association was found, possibly due to insufficient power. No clear association between testosterone and incident vertebral fractures was observed in either men or women...
  56. ncbi A human sex hormone-binding globulin isoform accumulates in the acrosome during spermatogenesis
    David M Selva
    Department of Obstetrics and Gynecology, Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, University of Western Ontario, London, Ontario N6A 4L6, Canada
    J Biol Chem 277:45291-8. 2002
    ..This is the first demonstration that human SHBG transcripts encode an SHBG isoform that remains within a cellular compartment...
  57. ncbi Associations of alcohol, height, and reproductive factors with serum hormone concentrations in postmenopausal Japanese women. Steroid hormones in Japanese postmenopausal women
    C Nagata
    Department of Public Health, Gifu University School of Medicine, Japan
    Breast Cancer Res Treat 44:235-41. 1997
    ..01). Reproductive factors as well as physical activity were not related to any of the hormone levels...
  58. ncbi Associations between sex hormone binding globulin and metabolic syndrome parameters in premenopausal obese women
    Fulya Akin
    Department of Endocrinology and Metabolism, Pamukkale Universitesi Endokrinoloji ve Metabolizma Hastaliklari, Kinikli Kampusu 20070 Denizli, Turkey
    Indian J Med Sci 62:407-15. 2008
    The aim of this study was to determine sex hormone binding globulin (SHBG) concentrations in premenopausal obese women and to evaluate the relationships between sex hormones and features of the metabolic syndrome (MetS).
  59. pmc Associations between the CYP17, CYPIB1, COMT and SHBG polymorphisms and serum sex hormones in post-menopausal breast cancer survivors
    Page E Abrahamson
    Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M4 B402, Seattle, WA, 98109 1024, USA
    Breast Cancer Res Treat 105:45-54. 2007
    ..These results provide little evidence that the CYP17, CYP1B1, and COMT polymorphisms are associated with different sex hormone levels in post-menopausal breast cancer survivors...
  60. ncbi Sex hormone-binding globulin is synthesized in target cells
    S M Kahn
    Department of Medicine, St Luke s Roosevelt Hospital Center, and College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA
    J Endocrinol 175:113-20. 2002
    ..We have reviewed the current state of knowledge on the SHBG gene and the role of SHBG in steroid signaling (we shall not address its function as a plasma-binding protein)...
  61. ncbi Role of endocytosis in cellular uptake of sex steroids
    Annette Hammes
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    Cell 122:751-62. 2005
    Androgens and estrogens are transported bound to the sex hormone binding globulin (SHBG). SHBG is believed to keep sex steroids inactive and to control the amount of free hormones that enter cells by passive diffusion...
  62. ncbi Emerging roles of steroid-binding globulins
    J D Caldwell
    Dept of Biomedical Sciences, University of Illinois College of Medicine, Rockford, 61107, USA
    Horm Metab Res 38:206-18. 2006
  63. ncbi Circulating sex steroids, sex hormone-binding globulin, and longitudinal changes in forearm bone mineral density in postmenopausal women and men: the Tromsø study
    Ashild Bjørnerem
    Institute of Community Medicine, University of Tromsø, N 9037, Tromsø, Norway
    Calcif Tissue Int 81:65-72. 2007
    ..We therefore conclude that the relations between sex steroids and bone loss are weak and measurements of sex steroids are unlikely to assist in clinical decision making...
  64. pmc Postmenopausal levels of oestrogen, androgen, and SHBG and breast cancer: long-term results of a prospective study
    A Zeleniuch-Jacquotte
    Department of Environmental Medicine, New York University School of Medicine, 650 First Avenue, New York, NY 10016, USA
    Br J Cancer 90:153-9. 2004
    ..They also suggest that the contribution of androgens to risk is largely through their role as substrates for oestrogen production...
  65. ncbi Immunohistochemical localization of sex hormone-binding globulin in normal and neoplastic breast tissue
    G Sinnecker
    , , Germany
    Horm Metab Res 22:47-50. 1990
    ..The apparent loss of this specific cell function in infiltrating carcinomas may result from dedifferentiation and change of cell membrane properties occurring during the process of neoplastic progression...
  66. ncbi The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs
    G L Hammond
    Department of Obstetrics and Gynecology, University of Western Ontario, Victoria Hospital, London, Canada
    Mol Endocrinol 3:1869-76. 1989
    ..Although the relative abundance of the various SHBG-related mRNAs in the testis has not been established, Northern blot analysis indicates that they are similar in size (1.6 kb) to that of hepatic SHBG mRNA...
  67. ncbi Localization of the human sex hormone-binding globulin gene (SHBG) to the short arm of chromosome 17 (17p12----p13)
    D Berube
    Department of Molecular Genetics, Laval University Medical Centre, Quebec, Canada
    Cytogenet Cell Genet 54:65-7. 1990
    ..In this way, the SHBG gene has been localized to the p12----p13 bands of chromosome 17...
  68. ncbi Sex hormone levels and risk of cardiovascular events in postmenopausal women
    Kathryn M Rexrode
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Ave E, Boston, Mass 02215, USA
    Circulation 108:1688-93. 2003
    ..Despite diffuse effects of sex hormones on the cardiovascular system, few prospective studies have examined the relationship of plasma androgens and estrogens with risk of cardiovascular disease (CVD) in postmenopausal women...
  69. pmc Sex hormone binding globulin and risk factors for breast cancer in a population of normal women who had never used exogenous sex hormones
    J W Moore
    Clinical Endocrinology Laboratory, Imperial Cancer Research Fund, London, UK
    Br J Cancer 56:661-6. 1987
    b>Sex hormone binding globulin (SHBG) concentrations were measured by immunoradiometric assay in serum samples from 1,221 healthy female volunteers aged 34-79 who had never used oral contraceptives or hormone replacement therapy, had no ..
  70. ncbi Circulating levels of sex hormones and their relation to risk factors for breast cancer: a cross-sectional study in 1092 pre- and postmenopausal women (United Kingdom)
    P K Verkasalo
    Imperial Cancer Research Fund Cancer Epidemiology Unit, University of Oxford, UK
    Cancer Causes Control 12:47-59. 2001
    ..To investigate the relationships between plasma concentrations of sex hormones and risk factors for breast cancer...
  71. ncbi Anthropometric measures, endogenous sex steroids and breast cancer risk in postmenopausal women: a study within the EPIC cohort
    Sabina Rinaldi
    International Agency for Research on Cancer IARC WHO, Lyon, France
    Int J Cancer 118:2832-9. 2006
    ..Our data indicate that the relationship of adiposity with breast cancer in postmenopausal women could be partially explained by the increases in endogenous estrogens, and by a decrease in levels of SHBG...
  72. ncbi Endogenous levels of serum estradiol and sex hormone binding globulin determine bone mineral density, bone remodeling, the rate of bone loss, and response to treatment with estrogen in elderly women
    Prema B Rapuri
    Bone Metabolism Unit, Creighton University, School of Medicine, 601 North 30th Street, Room 6718, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 89:4954-62. 2004
    ..Women with a serum estradiol level of less than 9 pg/ml (33 pmol/liter) are optimal candidates for estrogen therapy for osteoporosis prevention...
  73. ncbi Sex hormone binding globulin and aging
    J D Caldwell
    Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USA
    Horm Metab Res 41:173-82. 2009
    ..This review will discuss the possibility that sex hormone binding globulin (SHBG) plays an active role in the aging process...
  74. ncbi The biological variation of sex hormone-binding globulin in type 2 diabetes: implications for sex hormone-binding globulin as a surrogate marker of insulin resistance
    Vijay Jayagopal
    Diabetes Care 27:278-80. 2004
  75. ncbi Sex hormone-binding globulin, its membrane receptor, and breast cancer: a new approach to the modulation of estradiol action in neoplastic cells
    N Fortunati
    II U O A D U Medicina Generale, Azienda Ospedaliera S Giovanni Battista, and Dipartimento di Fisiopatologia Clinica, Universita di Torino, Italy
    J Steroid Biochem Mol Biol 69:473-9. 1999
    ..Thus, the local production of SHBG obtained with transfection could be a useful tool to control cell growth in estrogen-dependent breast cancer...
  76. ncbi Expression of rabbit sex hormone-binding globulin during pregnancy and prenatal development and identification of a novel isoform
    Kwong Man Ng
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong, China
    Endocrinology 146:1965-72. 2005
    ..Because the SHBG isoform it encodes lacks appreciable steroid-binding activity, it may function beyond that of the widely accepted role of SHBG as a steroid-transport protein...
  77. ncbi Expression of sex hormone-binding globulin (SHBG) in human granulosa-lutein cells
    T Forges
    Centre d assistance médicale à la procréation, maternité régionale et universitaire, Nancy, France
    Mol Cell Endocrinol 219:61-8. 2004
    ..These results demonstrate a local synthesis of SHBG in GLC and raise the question of the physiological significance of these findings in follicular physiology...
  78. ncbi Sex steroids and the free hormone hypothesis
    William Rosner
    Cell 124:455-6; author reply 456-7. 2006
  79. ncbi Sex hormone-binding globulin, estradiol, and bone turnover markers in male osteoporosis
    C Lormeau
    Department of Rheumatology, Lille University Hospital, 59037 Lille Cedex, France
    Bone 34:933-9. 2004
    ..Finally, our findings are in agreement with previous studies which suggest that serum SHBG is a new biological marker of fracture risk in men...
  80. ncbi Control of the membrane sex hormone-binding globulin-receptor (SHBG-R) in MCF-7 cells: effect of locally produced SHBG
    N Fortunati
    Laboratorio di Endocrinologia, Azienda Ospedaliera S Giovanni B ta, Torino, Italy
    Steroids 63:282-4. 1998
    ....
  81. ncbi Effects of seven low-dose combined oral contraceptives on sex hormone binding globulin, corticosteroid binding globulin, total and free testosterone
    N van der Vange
    Department of Gynaecology, University Hospital of Utrecht, The Netherlands
    Contraception 41:345-52. 1990
    The effect of seven low-dose oral contraceptive preparations on sex hormone binding globulin (SHBG), cortisol binding globulin (CBG), total and absolute free testosterone were investigated in groups of 10 healthy volunteers...
  82. pmc Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis
    S Gershagen
    Department of Clinical Chemistry, University of Lund, Malmo General Hospital, Sweden
    Nucleic Acids Res 17:9245-58. 1989
    A genomic cosmid clone for human sex hormone binding globulin (SHBG), a liver-secreted plasma glycoprotein that binds sex steroids, was isolated with a previously characterized liver cDNA as probe...
  83. ncbi Conjugated estrogen/progestagen versus tibolone hormone replacement therapy in postmenopausal women: Effects on carbohydrate metabolism and serum sex hormone-binding globulin
    Inga Stina Odmark
    Department of Clinical Science, Obstetrics and Gynecology, University of Umea, Umea, Sweden
    Maturitas 53:89-96. 2006
    ..To study the effects of different types of continuous hormone replacement therapy on carbohydrate metabolism...
  84. ncbi The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain
    G L Hammond
    FEBS Lett 215:100-4. 1987
    ..The results suggest that a portion of the steroid-binding domain of SHBG is located between residue 296 and the 35 predominantly hydrophilic residues at the C-terminus of the protein...
  85. ncbi Serum concentrations of estrogens, sex hormone binding globulin, and androgens and risk of breast hyperplasia in postmenopausal women
    Catherine Schairer
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS, Room 8020 MSC 7234, Rockville, MD 20852 7234, USA
    Cancer Epidemiol Biomarkers Prev 14:1660-5. 2005
    We sought to determine whether serum concentrations of estrogens, androgens, and sex hormone binding globulin in postmenopausal women were related to the presence of mammary hyperplasia, an established breast cancer risk factor.
  86. pmc Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3)
    Jiyoung Ahn
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Hum Mol Genet 18:3749-57. 2009
    ..8%, P = 1.82 x 10(-6)). Genetic variation in genes in the sex steroid hormone pathway is associated with differences in circulating SHBG and sex steroid hormones...
  87. pmc The association of breast mitogens with mammographic densities
    N F Boyd
    Division of Epidemiology and Statistics, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada M5G 1K9
    Br J Cancer 87:876-82. 2002
    ..information, anthropometric measures, and blood samples were obtained, and oestradiol, progesterone, sex hormone binding globulin, growth hormone, insulin-like growth factor-I and its principal binding protein, and prolactin measured...
  88. ncbi Identification of sex hormone-binding globulin in the human hypothalamus
    Zsofia Herbert
    Ludwig Maximilian Universitat Munchen, Department of Biology 2, Munich, Germany
    Neuroendocrinology 81:287-93. 2005
    ..The multiple localizations of SHBG suggest neurohypophyseal and neuroendocrine functions. The biochemical data suggest that CSF SHBG is of brain rather than blood origin...
  89. ncbi The association of endogenous sex steroids and sex steroid binding proteins with mammographic density: results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density Study
    Gail A Greendale
    Division of Geriatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095 1687, USA
    Am J Epidemiol 162:826-34. 2005
    ..These results suggest that some sex steroids may increase the risk of breast cancer by stimulating breast epithelial or stromal proliferation, which appears on a mammogram as higher density...
  90. pmc Identification, characterization and expression of novel Sex Hormone Binding Globulin alternative first exons in the human prostate
    Tomàs Pinós
    Institut de Recerca Hospital Universitari Vall d Hebron, Barcelona, Spain
    BMC Mol Biol 10:59. 2009
    The human Sex Hormone Binding Globulin (SHBG) gene, located at 17p13.1, comprises, at least, two different transcription units regulated by two different promoters...
  91. ncbi The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap
    D R Joseph
    Applied Genetics Laboratories, Biotechnology Development Institute, University of Florida, Alachua 32615, USA
    Steroids 63:2-4. 1998
    ..It will be of particular interest to determine if triplet instability affects ABP/SHBG gene expression. A triplet instability in the X-linked androgen receptor gene causes spinal and bulbar muscular atrophy...
  92. ncbi Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels
    Nectaria Xita
    Division of Endocrinology, University of Ioannina, Ioannina 45110, Greece
    J Clin Endocrinol Metab 88:5976-80. 2003
    ....
  93. ncbi Evidence that fibulin family members contribute to the steroid-dependent extravascular sequestration of sex hormone-binding globulin
    Kwong Man Ng
    Department of Obstetrics and Gynecology, University of British Columbia, and Child and Family Research Institute, Vancouver V5Z 4H4, Canada
    J Biol Chem 281:15853-61. 2006
    ..Given the interplay between fibulins and numerous proteins within the basal lamina, interactions between SHBG and matrix proteins may exert novel biological effects...
  94. ncbi Relationship between testosterone, sex hormone binding globulin and plasma amyloid beta peptide 40 in older men with subjective memory loss or dementia
    M J Gillett
    Department of Endocrinology and Diabetes, Fremantle Hospital, Western Australia, Australia
    J Alzheimers Dis 5:267-9. 2003
    In a group of 28 older men with either subjective memory loss or dementia, serum total testosterone and sex hormone binding globulin (SHBG) correlated inversely with plasma levels of amyloid beta peptide 40 (Abeta40, r=-0.5, P=0...
  95. ncbi Associations among mammographic density, circulating sex hormones, and polymorphisms in sex hormone metabolism genes in postmenopausal women
    Ruth Warren
    Department of Radiology, University of Cambridge, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:1502-8. 2006
    ....
  96. ncbi Sex steroid hormones, upper body obesity, and insulin resistance
    Nicola Abate
    Center for Human Nutrition, Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 87:4522-7. 2002
    ..Low plasma levels of bioavailable testosterone do not independently predict excessive insulin resistance, beta-cell dysfunction, or hepatic glucose output in normogonadal men...
  97. ncbi Visceral and subcutaneous adipose tissue assessed by magnetic resonance imaging in relation to circulating androgens, sex hormone-binding globulin, and luteinizing hormone in young men
    Torben Leo Nielsen
    Department of Endocrinology, Odense University Hospital, 5250 Odense SV, Denmark
    J Clin Endocrinol Metab 92:2696-705. 2007
    ..No large studies of young men have examined circulating sex hormones in relation to visceral and sc adipose tissues...
  98. ncbi Serum sex hormone-binding globulin, a determinant of cardiometabolic disorders independent of abdominal obesity and insulin resistance in elderly men and women
    Altan Onat
    Turkish Society of Cardiology, Istanbul University, 34384 Istanbul, Turkey
    Metabolism 56:1356-62. 2007
    ..Low SHBG may be an important independent factor for cardiometabolic risk, particularly in women...
  99. ncbi The relationship between endogenous testosterone, preandrogens, and sex hormone binding globulin and knee joint structure in women at midlife
    F S Hanna
    Women s Health Program, Department of Medicine, Central and Eastern Clinical School, Monash University, Alfred Hospital, Prahran, Victoria, Australia
    Semin Arthritis Rheum 37:56-62. 2007
    To evaluate the relationship between serum testosterone (T), preandrogens and sex hormone binding globulin (SHBG), and the knee structure in middle-aged women without knee pain.
  100. ncbi Sex hormone-binding globulin in the human prostate is locally synthesized and may act as an autocrine/paracrine effector
    Daniel J Hryb
    Department of Medicine, St Luke s Roosevelt Hospital Center, and College of Physicians and Surgeons, Columbia University, New York, New York 10019, USA
    J Biol Chem 277:26618-22. 2002
    ..These observations are consistent with the hypothesis that SHBG, destined to participate in signaling at the cell membrane, is locally regulated and produced...
  101. ncbi The effects of metformin and diet on plasma testosterone and leptin levels in obese men
    M Ozata
    Department of Endocrinology and Metabolism, Gulhane School of Medicine, Etlik Ankara, Turkey
    Obes Res 9:662-7. 2001
    ..The aim of this study was to investigate the effects of combined hypocaloric diet and metformin on circulating testosterone and leptin levels in obese men with or without type 2 diabetes...

Research Grants62

  1. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    ..data collection and 2 years after randomization, we propose to examine ESH (testosterone, estradiol, sex hormone binding globulin) and follicle stimulating hormone (FSH) in a subset of DPP women without exogenous hormone use (n=865) ..
  2. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..insulin-like growth factor 1 (IGF-1), IGF binding protein 3, estrone, estradiol, androstenedione and sex hormone binding globulin. Our secondary aims are to determine the effects of PPE on the following proposed biomarkers of breast ..
  3. Non-Hodgkin lymphoma in women: reproductive, hormonal and genetic factors
    Paige M Bracci; Fiscal Year: 2011
    ....
  4. Role of the Sex Hormones and Insulin/IGF-Axes in Endometrial Cancer Recurrence
    Howard D Strickler; Fiscal Year: 2012
    ..levels of insulin, total and free IGF-I, IGF-II, IGFBP-1 and -3, estradiol, estrone, progesterone and sex hormone binding globulin (SHBG);(ii) tumor expression of IGF-I, IGF-II, IGFBP-1 and -3 mRNA (based on RT-PCR), and of the ..
  5. Risk Factors for Ischemic Stroke in Women
    Kathryn M Rexrode; Fiscal Year: 2012
    ..Specifically, we will test whether testosterone, estradiol, dehydroepiandrosterone sulfate (DHEAS), and sex hormone binding globulin (SHBG) might mediate hormonal risk of ischemic stroke...
  6. Study of Women's Health Across the Nation V: Endocrinology/CLASS Laboratory
    Daniel S McConnell; Fiscal Year: 2013
    ..Through SWAN I, II and III we have shown, both cross-sectionally and longitudinally: 1) sex hormone binding globulin (SHBG) to be most strongly associated with cardiovascular risk factors, metabolic syndrome, body ..
  7. Protein S: Neurovascular Protection in Stroke
    Berislav V Zlokovic; Fiscal Year: 2010
    ..and oxygen/glucose deprivation (OGD) injuries;(3) PS's cytoprotection requires its C-terminal sex hormone binding globulin-like (rSHBG) module, but not the N-terminal micro-PS [Gla domain, thrombin-sensitive (TSR) region, EGF1 ..
  8. Sex Differences in Vascular Markers of Stroke Risk
    Cheryl D Bushnell; Fiscal Year: 2012
    ..In addition, endogenous hormones such as estradiol and sex hormone binding globulin, as well as menopausal status impact cardiovascular risk...
  9. Determinants of breast tissue composition in young women
    Johanna M Rommens; Fiscal Year: 2013
    ..We also found that blood levels of growth hormone and sex hormone binding globulin in all subjects were associated with breast water content...
  10. Phytoestrogen and Endogenous Estrogen Exposure and Risk of Stroke
    Xianglan Zhang; Fiscal Year: 2013
    ..Study results may contribute to the development of new strategies for the primary prevention of stroke. ..
  11. Clinical Correlates of High and Low Testosterone in Women: Framingham Heart Study
    Andrea Coviello; Fiscal Year: 2012
    ..abstract_text> ..
  12. Androgen-Estrogen Balance in CVD Risk
    JENNIFER SHUWEN LEE; Fiscal Year: 2013
    ..men and women with diabetes;2) to determine if levels of circulating endogenous estrogen, androgen, and sex hormone binding globulin (SHBG) levels are associated with subsequent pre-diabetes and diabetes;and 3) across the adult lifespan ..
  13. Basic Cancer Research in Cancer Health Disparities
    Radoslav Goldman; Fiscal Year: 2013
    ..This study proposes to examine how glycosylation of sex hormone binding globulin (SHBG) affects steroid hormone signaling in prostate cancer...
  14. Rosiglitazone and Clomiphene for Ovulation Induction
    Nicholas Cataldo; Fiscal Year: 2002
    ..on oral glucose tolerance testing (OGTT), and with changes in baseline LH, total and free testosterone, sex hormone binding globulin (SHBG), and insulin-like growth factor binding protein-1 (IGFBP-1) levels...
  15. INHIBIN GENE EXPRESSION IN TESTIS AND SERTOLI CELLS
    HUGH KEEPING; Fiscal Year: 1991
    ..The study of primate inhibin may also lead to a greater understanding of fertility and infertility in the human...
  16. BIOMEDICAL (BASIC)
    MARC JAMES GUNTER; Fiscal Year: 2009
    ..to evaluate the association of incident colorectal cancer with estradiol, estrone, progesterone and sex hormone binding globulin among women enrolled in the untreated arms of the WHI-CT (women not using E or E+P)...
  17. US STUDY OF SEMEN QUALITY IN PARTNERS OF PREGNANT WOMEN
    Shanna Swan; Fiscal Year: 2001
    ..of serum hormones (testosterone, inhibin-B, luteinizing hormone, follicle stimulating hormone, sex hormone binding globulin and estradiol), as well as testicular and other physical abnormalities, and the relationships between ..
  18. MECHANISMS OF ACTION IN DPP INTERVENTIONS
    Abbas Kitabchi; Fiscal Year: 2001
    ..Other rationales for the proposed study are that: (a) hyperandrogenism and decreased sex hormone binding globulin (SHBG) are known to be additional risk factors for development of NIDDM in certain female populations, (..
  19. STRENGTH--Survivor TRaining for ENhancinG Total Health
    Wendy Demark Wahnefried; Fiscal Year: 2002
    ..e., insulin, insulin-like growth factor-i, sex hormone binding globulin and lipoprotein profiles)...
  20. Female sexuality: modulation by estrogen and androgen
    Kim Wallen; Fiscal Year: 2005
    ..estrogens and that androgens regulate the bioavailability of these estrogens through interactions with sex hormone binding globulin (SHBG)...
  21. NEW YORK UNIVERSITY WOMENS HEALTH STUDY
    Paolo Toniolo; Fiscal Year: 2002
    ..Subjects who were pre-or post-menopausal at the time of cohort enrollment (i.e., at the time of the collection of baseline samples) will be considered in separate statistical analyses. ..
  22. SPORADIC MECHANISM OF THE ANTIPHOSPHOLIPID SYNDROME
    Joan Merrill; Fiscal Year: 2001
    ..Therefore, possible modulation by sex-hormones of interactions between these proteins will be addressed in this application. ..
  23. ADIPOSE DISTRIBUTION AND ATHEROSCLEROSIS
    JOHN CROUSE; Fiscal Year: 1992
    ..HDL2 cholesterol, apo A1, Apo B, postprandial lipid response to a fat rich meal, glucose, insulin, sex hormone binding globulin, and total and free testosterone...
  24. ORGANOCHLORINE PESTICIDES AND MALE GENITAL ANOMALIES
    Rajiv Bhatia; Fiscal Year: 2002
    ..The sex steroid hormone, testosterone, and sex hormone binding globulin, possible markers for reproductive system effects of DDT, will be measured from cord blood samples in a ..
  25. Mammographic Density in a Multi-Ethnic Cohort
    Laurel Habel; Fiscal Year: 2005
    ..abstract_text> ..
  26. EXERCISE EFFECT ON SEX HORMONES IN POSTMENOPAUSAL WOMEN
    Anne McTiernan; Fiscal Year: 2000
    ..total estrone, total estradiol, free estradiol, percent bioavailable estradiol, estrone sulfate, sex hormone binding globulin, albumin, testosterone, free testosterone, androstenedione, dehydroepiandrosterone, ..
  27. ENDOGENOUS SEX HORMONES, GENETICS, AND PROSTATE CANCER
    Chu Chen; Fiscal Year: 2001
    ..the hypotheses that the risk of prostate cancer is related to: 1) serum concentrations of testosterone, sex hormone binding globulin, androstenedione, dehydroepiandrosterone sulfate, 3-alpha-androstanediol glucuronide, and estradiol; 2) ..
  28. ENDOGENOUS ESTROGENS AND ENDOMETRIAL CANCER
    Anne Zeleniuch Jacquotte; Fiscal Year: 1999
    ..Serum samples will be assayed for estrone, estradiol, percent estradiol bound to sex hormone binding globulin and percent free estradiol...
  29. DETERMINANTS OF STEROID HORMONES IN BLACK AND WHITE MEN
    Susan Gapstur; Fiscal Year: 2006
    ..concentrations of 3alpha-androstanediol glucuronide (AAG), IGF-1, IGF binding protein-3 (IGFBP-3), and sex hormone binding globulin (SHBG) were measured in serially collected serum samples over an eight-year period from 624 black and ..
  30. RANDOMIZED TRIAL OF ESTROGEN-ATHEROSCLEROSIS REGRESSION
    Thomas Clarkson; Fiscal Year: 1992
    ..with atherosclerotic lesions? and finally, d) What is the relationship between the plasma levels of sex hormone binding globulin and the degree of coronary atherosclerosis? The study represents the first effort that we are aware of ..
  31. AUTOANTIBODIES AS BIOMARKERS OF BREAST CANCER
    Krystyna Frenkel; Fiscal Year: 2001
    ..Samples will be decoded and relationships established between anti-HMdU aAb and: 1) Breast CA, 2) family history of breast CA,3) HMdU levels, 4) estrogens, and 5) diet. ..
  32. NCI DIETARY GUIDELINES IN AFRICAN AMERICAN CHURCHES
    Boyd Switzer; Fiscal Year: 2000
    ..waist-hip measures, body mass index and serum cholesterol, vitamins A and E, carotenoids, sex hormone binding globulin, and hormones (estradiol and testosterone)...
  33. NIA ACADEMIC AWARD--ANDROGEN ACTION IN THE ELDERLY MALE
    JOYCE TENOVER; Fiscal Year: 1992
    ..including a moderate decrease in total serum T and a larger decline in "bioavailable T" (T not bound to sex hormone binding globulin, SHBG)...
  34. BIOSOCIAL MODELS OF WOMEN'S GENDER ROLE BEHAVIOR
    J Udry; Fiscal Year: 1991
    ..Serum will be assayed for testosterone, sex hormone binding globulin, estradiol, progesterone, androstenedione, and luteinizing hormone...
  35. COX-2 EXPRESSION AND RISK FACTORS FOR BLADDER CANCER
    Ronald Ross; Fiscal Year: 2002
    ..5 or greater for the main effects of most of the genotypes of interest. We will also have substantial power to detect interactions between these genotypes and established breast cancer risk factors. ..
  36. Serum Sex Hormonoe Levels & Subclinical Atherosclerosis
    Pamela Ouyang; Fiscal Year: 2006
    ..of total (and free) testosterone (T), dehydroepiandrosterone (DHEA), 17beta-estradiol (E2), and sex hormone binding globulin (SHBG) in stored serum samples collected at the MESA baseline exam will be assessed...
  37. Serum Sex Hormone Levels and Subclinical Atherosclerosis
    Susan Gapstur; Fiscal Year: 2006
    ..of total (and free) testosterone (T), dehydroepiandrosterone (DHEA), 17 beta-estradiol (E2), and sex hormone binding globulin (SHBG) in stored serum samples collected at the MESA baseline exam will be assessed...
  38. GENETIC HORMONAL AND BEHAVIORAL DETERMINANTS OF OBESITY
    Jennifer Hays; Fiscal Year: 2000
    ..We will also construct a comprehensive obesity risk assessment profile of the most important genetic, hormonal, and behavioral, determinants we identify. ..
  39. In Vivo Molecular Imaging of Estrogen Receptors
    Raghavan Rajagopalan; Fiscal Year: 2006
    ..uptake of estrogen like steroidal molecules is intimately related to the binding of the steroids to sex hormone binding globulin (SHBG)...
  40. SWAN Sleep Study II - Michigan Center
    MaryFran Sowers; Fiscal Year: 2008
    ..The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances. [unreadable] [unreadable] [unreadable]..
  41. Functional Status and the Menopause Transition
    MaryFran R Sowers; Fiscal Year: 2010
    ..Among the elderly, older women live longer, develop more chronic disease and experience more prolonged and severe disability than older men. ..
  42. Change in Bone, Arthritis, Function: Hormones & Obesity
    MaryFran Sowers; Fiscal Year: 2009
    ....
  43. Estrogen, Metabolism, Menopause, and Health Outcomes
    MaryFran Sowers; Fiscal Year: 2006
    ..This is a unique opportunity to prospectively integrate lifestyle elements with measures of hormone metabolism pathways into a comprehensive examination of multiple human health effects. ..
  44. MAMMOGRAPHIC PARENCHYMAL PATTERNS AND BREAST CANCER RISK
    Paolo Toniolo; Fiscal Year: 1993
    ..A three-year project is planned...
  45. STEROID CONTROL OF CENTRAL OXYTOCIN RELEASE
    Jack Caldwell; Fiscal Year: 1999
    ..studies will examine whether E-6-BSA stimulates OT release by acting on a membrane/cytoplasmic E receptor or on a novel receptor for sex hormone binding globulin. Both undergraduate and graduate students will participate in the research.
  46. INSULIN, IGF-1 & CANCERS OF BREAST, ENDOMETRIUM & OVARY
    Rudolf Kaaks; Fiscal Year: 2001
    ..All studies are based on the same underlying population, obtained by combining three prospective cohort studies that are currently ongoing in New York, Umea (Sweden) and Milan (Italy). ..
  47. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  48. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..The present proposal develops a general biomathematical framework for dissecting otherwise observed pathways that control hormone output in aging, stress and disease. [unreadable] [unreadable] [unreadable]..
  49. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  50. Characterization of Central ABP/SHBG Receptors
    Jack Caldwell; Fiscal Year: 2005
    ..Whereas the more commonly known model suggests that steroid-binding proteins such as sex hormone binding globulin (SHBG) are only made in the periphery and only deliver steroids to be passively released at the target ..
  51. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  52. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  53. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ....
  54. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  55. Lifestyle, insulin, IGF-I and colorectal cancer
    Rudolf Kaaks; Fiscal Year: 2005
    ..This study seeks to increase understanding of etiologic mechanisms relating over nutrition to colon cancer development, which will eventually allow the in formulation of more precise nutritional guidelines for efficient prevention. ..
  56. The Role of Prolactin in the Etiology of Postmenopausal Breast Cancer
    Shelley Tworoger; Fiscal Year: 2008
    ..This potentially may affect public health by increasing our understanding of how breast cancer develops, which in turn can lead to a better understanding of how to prevent this disease. [unreadable] [unreadable]..
  57. ORAL AND SKELETAL BONE LOSS IN OLDER MEN
    Eric Orwoll; Fiscal Year: 2006
    ..Since the MrOS cohort is already established through other funds, this request will provide a very cost-effective means for addressing these important oral health issues. ..
  58. Outcomes of Sleep Disorders in Older Men-Portland
    Eric Orwoll; Fiscal Year: 2007
    ..We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions. ..
  59. ADAM: Androgen Deprivation vs. Antiandrogen Monotherapy
    Matthew Smith; Fiscal Year: 2004
    ..In addition, this project will provide important insights into the relative contributions of testosterone and estrogen in bone metabolism, and maintenance of muscle size and strength in older men. ..
  60. Effect of Continuous vs. Sequential Oral Contraception
    RICHARD LEGRO; Fiscal Year: 2004
    ..Therefore, the risks and benefits of a CCOCP regimen are an important women's health issue that warrant investigation. ..
  61. Hormones During Weight Loss in Breast Cancer Survivors
    Cheryl Rock; Fiscal Year: 2004
    ....