Genomes and Genes
monosaccharide transport proteins
Summary: A large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES.
Publications383 found, 100 shown here
- A versatile monosaccharide transporter that operates in the arbuscular mycorrhizal fungus Glomus sp is crucial for the symbiotic relationship with plantsNicole Helber
Plant Microbial Interactions Group, Karlsruhe Institute of Technology, Hertzstrasse 16, D 76187 Karlsruhe, Germany
Plant Cell 23:3812-23. 2011..These results imply that the sugar uptake system operating in this symbiosis is more complex than previously anticipated...
- Molecular identification and physiological characterization of a novel monosaccharide transporter from Arabidopsis involved in vacuolar sugar transportAlexandra Wormit
Pflanzenphysiologie, Technische Universitat Kaiserslautern, D 67653 Kaiserslautern, Germany
Plant Cell 18:3476-90. 2006..Our results indicate that TMT1 is involved in vacuolar monosaccharide transport and plays a major role during stress responses...
- A previously unknown maltose transporter essential for starch degradation in leavesTotte Niittyla
Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, UK
Science 303:87-9. 2004..The severe mex1 phenotype demonstrates that MEX1is the predominant route of carbohydrate export from chloroplasts at night. Homologous genes in plants including rice and potato indicate that maltose export is of widespread significance...
- CAP defines a second signalling pathway required for insulin-stimulated glucose transportC A Baumann
Department of Physiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
Nature 407:202-7. 2000..Thus, localization of the Cbl-CAP complex to lipid rafts generates a pathway that is crucial in the regulation of glucose uptake...
- The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulinMayumi Inoue
Life Sciences Institute, Departments of Internal Medicine and Physiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Nature 422:629-33. 2003..So, the exocyst might have a crucial role in the targeting of the Glut4 vesicle to the plasma membrane, perhaps directing the vesicle to the precise site of fusion...
- Glucose-sensing mechanisms in eukaryotic cellsF Rolland
Laboratorium voor Moleculaire Celbiologie, Instituut voor Plantkunde en Microbiologie, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B-3001 Leuven-Heverlee, Flanders, Belgium
Trends Biochem Sci 26:310-7. 2001....
- Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacYOsman Mirza
Department of Biological Sciences, Membrane Protein Crystallography Group, Imperial College London, London, UK
EMBO J 25:1177-83. 2006..Thus, substrate induces formation of the sugar-binding site, as well as the initial step in H+ transduction...
- Glucose uptake kinetics and transcription of HXT genes in chemostat cultures of Saccharomyces cerevisiaeJ A Diderich
E C Slater Institute, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
J Biol Chem 274:15350-9. 1999..At high dilution rates, however, the estimated glucose transport capacity was too low to account for the in situ glucose consumption rate...
- Families of transmembrane sugar transport proteinsM H Saier
Department of Biology, University of California at San Diego, La Jolla, CA 92093 0116, USA
Mol Microbiol 35:699-710. 2000..This review provides a comprehensive guide to the diversity of carriers that mediate the transport of sugar-containing molecules across cell and organellar membranes...
- Roles of multiple glucose transporters in Saccharomyces cerevisiaeC H Ko
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208
Mol Cell Biol 13:638-48. 1993..HXT1 and HXT3 are differentially regulated. HXT1::lacZ is maximally expressed during exponential growth whereas HXT3::lacZ is maximally expressed after entry into stationary phase...
- Expression of high-affinity glucose transport protein Hxt2p of Saccharomyces cerevisiae is both repressed and induced by glucose and appears to be regulated posttranslationallyD L Wendell
Department of Viticulture and Enology, University of California, Davis 95616 8749
J Bacteriol 176:3730-7. 1994..Similarly, Hxt2p was found to be expressed under low-glucose conditions in an snf3 mutant which does not display high-affinity uptake. This finding suggests that SNF3 may be involved in the posttranslational regulation of Hxt2p...
- Lactose permease and the alternating access mechanismIrina Smirnova
Department of Physiology and Department of Microbiology, University of California, Los Angeles, California 90095, United States
Biochemistry 50:9684-93. 2011..Evidence is also presented indicating that opening of the periplasmic cavity is probably the limiting step for binding and perhaps transport...
- High-copy suppression of glucose transport defects by HXT4 and regulatory elements in the promoters of the HXT genes in Saccharomyces cerevisiaeG Theodoris
Department of Viticulture and Enology, University of California, Davis 95616
Genetics 137:957-66. 1994..The promoters of SNF3 and of other glycolytic genes examined did not suppress snf3 in multicopy. Suppression of snf3 by DDSE is dependent on the presence of either HXT2 or HXT3...
- Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expressionS Ozcan
Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 93:12428-32. 1996..Thus, the Rgt2p and Snf3p glucose transporters appear to act as glucose receptors that generate an intracellular glucose signal, suggesting that glucose signaling in yeast is a receptor-mediated process...
- Exogenous inositol and genes responsible for inositol transport are required for mating and sporulation in Shizosaccharomyces pombeC Niederberger
Institute of General Microbiology, University of Bern, Switzerland
Curr Genet 33:255-61. 1998..The itr2 gene is essential for cell growth and its mRNA level is repressed by glucose. Mutant IM49 is also complemented by a multicopy suppressor gene (itr1) which codes for a putative hexose transporter with unknown substrate specifity...
- A putative high affinity hexose transporter, hxtA, of Aspergillus nidulans is induced in vegetative hyphae upon starvation and in ascogenous hyphae during cleistothecium formationHuijun Wei
Department of Microbiology, University of Marburg and Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, Marburg D 35043, Germany
Fungal Genet Biol 41:148-56. 2004..We found hxtA(p)::sgfp expression in developing cleistothecia specifically in ascogenous hyphae and propose that HxtA is a high affinity glucose transporter involved in sugar metabolism during sexual development...
- Haploid genetic screens in human cells identify host factors used by pathogensJan E Carette
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 326:1231-5. 2009..This approach has both conceptual and practical parallels with genetic approaches in haploid yeast...
- Role of Akt/protein kinase B in metabolismEileen L Whiteman
Dept Medicine and Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 415 Curie Blvd, 322 Clinical Research Building, Philadelphia, PA 19104, USA
Trends Endocrinol Metab 13:444-51. 2002....
- Protection from obesity-induced insulin resistance in mice lacking TNF-alpha functionK T Uysal
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Nature 389:610-4. 1997..These results indicate that TNF-alpha is an important mediator of insulin resistance in obesity through its effects on several important sites of insulin action...
- The alternating-access mechanism of MFS transporters arises from inverted-topology repeatsSebastian Radestock
Computational Structural Biology Group, Max Planck Institute of Biophysics, Max von Laue Str 3, 60438 Frankfurtam Main, Germany
J Mol Biol 407:698-715. 2011..More fundamentally, our model demonstrates that inverted-topology repeats provide the foundation for the alternating-access mechanisms of MFS transporters...
- Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiaeS Ozcan
Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
EMBO J 17:2566-73. 1998..These results support the idea that yeast senses glucose using two modified glucose transporters that serve as glucose receptors...
- Glut-1 and hexokinase expression: relationship with 2-fluoro-2-deoxy-D-glucose uptake in A431 and T47D cells in cultureL Aloj
Nuclear Medicine Department, Clinical Center, NIH, Bethesda, Maryland 20892 1180, USA
Cancer Res 59:4709-14. 1999..Our data indicate that in these cultured cells, FDG uptake correlates better with FDG phosphorylating activity of mitochondrial preparations rather than the level of expression of the Glut-1 or hexokinase I and II genes...
- Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucoseS Ozcan
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110
Mol Cell Biol 15:1564-72. 1995..Thus, the glucose repression and glucose induction mechanisms share some of the same components and may share the same primary signal generated from glucose...
- Sugar binding induces an outward facing conformation of LacYIrina Smirnova
Department of Physiology, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:16504-9. 2007..The DEER measurements in conjunction with molecular modeling based on the x-ray structure provide strong support for the alternative access model and reveal a structure for the outward-facing conformer of LacY...
- Structure and mechanism of the lactose permease of Escherichia coliJeff Abramson
Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK
Science 301:610-5. 2003..We propose a possible mechanism for lactose/proton symport (co-transport) consistent with both the structure and a large body of experimental data...
- Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry developmentLaurent G Deluc
Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Nevada 89557 0014, USA
BMC Genomics 8:429. 2007....
- GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetesA E Stenbit
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Nat Med 3:1096-101. 1997..The male GLUT4 +/- mice represent a good model for studying the development of NIDDM without the complications associated with obesity...
- Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase BSun Sik Bae
Howard Hughes Medical Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 278:49530-6. 2003....
- Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubulesSabina Semiz
Program in Molecular Medicine, 373 Plantation Street, University of Massachusetts Medical School, Worcester 01605, USA
EMBO J 22:2387-99. 2003..This insulin signaling pathway regulating KIF5B function appears to be required for GLUT4 translocation to the plasma membrane...
- Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervixR Airley
Cancer Research Campaign Experimental Radiation Oncology Group, Paterson Institute for Cancer Research
Clin Cancer Res 7:928-34. 2001..022) but did not significantly effect disease-free or recurrence-free survival. These findings suggest that Glut-1 be an intrinsic marker of hypoxia that can easily be applied in a clinical setting...
- Cloning and characterization of seven cDNAs for hyperosmolarity-responsive (HOR) genes of Saccharomyces cerevisiaeT Hirayama
Laboratory of Plant Molecular Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
Mol Gen Genet 249:127-38. 1995..In addition, Hog1p, one of the MAP kinases in yeast, appeared to be involved in the regulation of expression of HOR genes, although its function seemed to be insufficient for the overall regulation of expression of these genes...
- Transport activity of rice sucrose transporters OsSUT1 and OsSUT5Ye Sun
Department of Plant Biology, University of Minnesota, 250 Biological Sciences Center, St Paul, MN 55108 USA
Plant Cell Physiol 51:114-22. 2010..In conclusion, differences in transport activity between OsSUT1 and OsSUT5 indicate that type II SUTs have a range of transport activities that are tuned to their function in the plant...
- GLUT-1 expression in ovarian carcinoma: association with survival and response to chemotherapyG Cantuaria
Department of Obstetrics and Gynecology, University of Miami, Jackson Memorial Hospital, Miami, Florida, USA
Cancer 92:1144-50. 2001..The objective of this study was to investigate the association of GLUT-1 with response to chemotherapy and outcome in patients with ovarian carcinoma...
- Polarized distribution of glucose transporter isoforms in Caco-2 cellsD S Harris
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110
Proc Natl Acad Sci U S A 89:7556-60. 1992..The amino acid sequence identity (57%) and structural conservation between GLUT1 and GLUT3 may make these transporters an ideal model system for examining the molecular basis for polarized sorting of membrane proteins...
- A Golgi-localized hexose transporter is involved in heterotrimeric G protein-mediated early development in ArabidopsisHelen X Wang
Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
Mol Biol Cell 17:4257-69. 2006..SGB1 is shown here to be a Golgi-localized hexose transporter and acts genetically with AGB1 in early seedling development...
- The osmotolerant fructophilic yeast Zygosaccharomyces rouxii employs two plasma-membrane fructose uptake systems belonging to a new family of yeast sugar transportersMaria José Leandro
CBAA, Instituto Superior de Agromonia, TUL, 1349 017 Lisboa, Portugal
Microbiology 157:601-8. 2011....
- Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosisIlse A Hoppenbrouwers
Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands
J Hum Genet 54:676-80. 2009..Several of these risk genes, including CD58 and CLEC16A, are shared by different autoimmune diseases. Fine mapping studies will be needed to determine the functional contributions to distinct autoimmune phenotypes...
- Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and humanShuichi Hiraoka
Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Nat Med 13:1363-7. 2007..Our findings highlight the crucial role of NSTs in proteoglycan function and cartilage metabolism, thus revealing a new paradigm for skeletal disease and glycobiology...
- Glucose uptake in Trichoderma harzianum: role of gtt1Jesús Delgado-Jarana
Departamento de Genetica, Facultad de Biologia, 41012 Seville, Spain
Eukaryot Cell 2:708-17. 2003..The cloning of the first filamentous ascomycete glucose transporter is the first step in elucidating the mechanisms of glucose uptake and carbon repression in aerobic fungi...
- Manipulating phospholipids for crystallization of a membrane transport proteinLan Guan
Department of Physiology, University of California, Los Angeles, CA 90095 1662, USA
Proc Natl Acad Sci U S A 103:1723-6. 2006..Thus, it is likely that manipulation of PL is a good strategy for predominantly hydrophobic membrane proteins like LacY...
- Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiaeJ Nikawa
Department of Biochemistry, Gunma University School of Medicine, Maebashi, Japan
J Biol Chem 266:11184-91. 1991..Northern blot analysis showed that ITR1 mRNA was much more abundant than ITR2 mRNA. The previously isolated myo-inositol transport mutant was determined to be defective in ITR1...
- Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometryAdam B Weinglass
Department of Physiology, Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095 1662, USA
EMBO J 22:1467-77. 2003..The approach demonstrates that mass spectrometry can provide a powerful means of analyzing ligand interactions with integral membrane proteins...
- How the Rgt1 transcription factor of Saccharomyces cerevisiae is regulated by glucoseJeffrey A Polish
Department of Genetics, Washington University, Saint Louis, Missouri 63110, USA
Genetics 169:583-94. 2005..Glucose induces HXT1 gene expression by causing Mth1 degradation, allowing Rgt1 phosphorylation, and leading to the intramolecular interaction that inhibits DNA binding of Rgt1...
- Fsy1, the sole hexose-proton transporter characterized in Saccharomyces yeasts, exhibits a variable fructose:H(+) stoichiometryJorge Anjos
Centro de Recursos Microbiológicos, Departamento de Ciências da Vida, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829 516 Caparica, Portugal
Biochim Biophys Acta 1828:201-7. 2013....
- Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cellsL J Foster
Cell Biology Programme, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
Am J Physiol Cell Physiol 279:C877-90. 2000..Potential modes of regulation of this process are discussed, including SNARE phosphorylation and interaction with the cytoskeleton...
- Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic fluxE Reifenberger
Institut für Milrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
Mol Microbiol 16:157-67. 1995..These results demonstrate that individual HXT proteins can function independently as hexose transporters, and that most of the metabolically relevant HXT transporters from S. cerevisiae have been identified...
- A heritable switch in carbon source utilization driven by an unusual yeast prionJessica C S Brown
Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
Genes Dev 23:2320-32. 2009....
- A glucose transport protein expressed predominately in insulin-responsive tissuesM J Charron
Whitehead Institute for Biomedical Research, Cambridge, MA 02142
Proc Natl Acad Sci U S A 86:2535-9. 1989..This GT-like cDNA is the fourth member of the mammalian GT-related gene family identified to date. We propose that it encodes an insulin-sensitive GT...
- Glut 1 expression in transitional cell carcinoma of the urinary bladder is associated with poor patient survivalM Younes
Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Anticancer Res 21:575-8. 2001..0109), but showed no significant difference in the incidence of nodal metastasis (p = 0.4258). Our results suggest that Glut1 expression in TCCB is a marker of aggressive biologic potential in patients undergoing cystectomy...
- Functional expression and characterization of the Trypanosoma brucei procyclic glucose transporter, THT2M P Barrett
Universite de Bordeaux II, France
Biochem J 312:687-91. 1995..THT2 expressed in CHO cells behaved as a facilitated transporter, and was unaffected by FCCP or KCN over the whole substrate concentration range tested...
- Combinatorial control of gene expression by the three yeast repressors Mig1, Mig2 and Mig3Jakub Orzechowski Westholm
The Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, SE 751 24 Uppsala, Sweden
BMC Genomics 9:601. 2008..We have used microarrays to study global gene expression in all possible combinations of mig1, mig2 and mig3 deletion mutants...
- Residues gating the periplasmic pathway of LacYYonggang Zhou
Department of Physiology, University of California, Los Angeles, CA 90095 7327, USA
J Mol Biol 394:219-25. 2009..The data indicate that residues Ile40 and Asn245 play a primary role in gating the periplasmic cavity and provide further support for the alternating-access model...
- The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and IcShih Yin Chen
Section on Cellular Differentiation, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, USA
FASEB J 22:2206-13. 2008..Taken together, our results suggest that G6PT has a dual role as a G6P and a P(i) transporter and that GSD-Ib and GSD-Ic are deficient in the same G6PT gene...
- A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogsMartin Blume
Department of Molecular Parasitology, Humboldt University, Berlin, Germany
FASEB J 25:1218-29. 2011..This work provides a platform to facilitate the development of drugs against malaria, and it suggests a disease-control aspect by reducing parasite transmission...
- Mutational analysis of the SNF3 glucose transporter of Saccharomyces cerevisiaeL Marshall-Carlson
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Mol Cell Biol 10:1105-15. 1990..We also report the genetic mapping of the SNF3 locus on the left arm of chromosome IV...
- Structural determination of wild-type lactose permeaseLan Guan
Department of Physiology, University of California, Los Angeles, CA 90095 1662, USA
Proc Natl Acad Sci U S A 104:15294-8. 2007..Because the inward-facing conformation represents the lowest free-energy state, the rate-limiting step for transport may be the conformational change leading to the outward-facing conformation...
- Genotype/phenotype correlation in glycogen storage disease type 1b: a multicentre study and review of the literatureDaniela Melis
Dipartimento di Pediatria, Universita Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy
Eur J Pediatr 164:501-8. 2005..In three patients no mutations were detected...
- Inactivation of the glucose 6-phosphate transporter causes glycogen storage disease type 1bH Hiraiwa
Heritable Disorders Branch, NICHD, National Institutes of Health, Bethesda, Maryland, 20892, USA
J Biol Chem 274:5532-6. 1999....
- Mth1 receives the signal given by the glucose sensors Snf3 and Rgt2 in Saccharomyces cerevisiaeM J Lafuente
Instituto de Investigaciones Biom edicas Alberto Sols, CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
Mol Microbiol 35:161-72. 2000..A double mutant, snf3 rgt2, recovered sensitivity to glucose when MTH1 was deleted, thus showing that glucose signalling may occur independently of Snf3 and Rgt2. A model for the possible mode of action of Snf3 and Rgt2 is presented...
- Cloning and functional characterization of the mouse fructose transporter, GLUT5Christopher P Corpe
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Biochim Biophys Acta 1576:191-7. 2002....
- Structure-function analysis of the glucose-6-phosphate transporter deficient in glycogen storage disease type IbLi Yuan Chen
Section on Cellular Differentiation, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892, USA
Hum Mol Genet 11:3199-207. 2002..Finally, we show that degradation of both wild-type and mutant G6PT is inhibited by a potent proteasome inhibitor, lactacystin, demonstrating that G6PT is a substrate for proteasome-mediated degradation...
- The putative glucose 6-phosphate translocase gene is mutated in essentially all cases of glycogen storage disease type I non-aM Veiga-da-Cunha
Laboratory of Physiological Chemistry, Brussels, Belgium
Eur J Hum Genet 7:717-23. 1999..Isolated defects in microsomal Pi transporter or in microsomal glucose transporter must be very rare or have phenotypes that are not recognised as GSD I, so that in practice there are only two subtypes of GSD I (GSD Ia and GSD Ib)...
- Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentialityKsenija Slavic
Centre for Infection, Cellular and Molecular Medicine, St George s University of London, London, UK
Mol Microbiol 75:1402-13. 2010....
- Involvement of abscisic acid in the coordinated regulation of a stress-inducible hexose transporter (VvHT5) and a cell wall invertase in grapevine in response to biotrophic fungal infectionMatthew A Hayes
Commonwealth Scientific and Industrial Research Organization Plant Industry, Glen Osmond, South Australia 5064, Australia
Plant Physiol 153:211-21. 2010..Our data suggest a central role for ABA in the regulation of VvcwINV and VvHT5 expression during the transition from source to sink in response to infection by biotrophic pathogens...
- Aspergillus niger mstA encodes a high-affinity sugar/H+ symporter which is regulated in response to extracellular pHPatricia A vanKuyk
Molecular Genetics of Industrial Microorganisms Wageningen University, Dreijenlaan 2, 6703 HA Wageningen, The Netherlands
Biochem J 379:375-83. 2004..1-60 mM D-glucose, D-mannose, D-fructose or D-xylose. This indicates that A. niger possesses other transporters capable of compensating for the absence of MSTA...
- Insulin-regulated trafficking of dual-labeled glucose transporter 4 in primary rat adipose cellsK Dawson
Experimental Diabetes, Metabolism, and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, Maryland 20892-0842, USA
Biochem Biophys Res Commun 287:445-54. 2001..Thus, HA-GLUT4-GFP will be useful to study GLUT4 trafficking in vivo while GFP on the N-terminus interferes with intracellular retention...
- The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporterK Luhn
Institut fur Zellbiologie, ZMBE, Universitat Munster, Munster, and Max Planck Institut für Klinische and Physiologische Forschung, Bad Nauheim, Germany
Nat Genet 28:69-72. 2001..Thus, we have identified the first putative GDP-fucose transporter, which has been highly conserved throughout evolution. A point mutation in its gene is responsible for the disease in this patient with LAD II...
- Molecular and functional characterization of a fructose specific transporter from the gray mold fungus Botrytis cinereaGunther Doehlemann
University of Kaiserslautern, Department of Biology, P O Box 3049, 67653 Kaiserslautern, Germany
Fungal Genet Biol 42:601-10. 2005..Thus, we propose that the specific effect of fructose on germination is not due to transport but rather to an as yet unknown intracellular sensing...
- Hexose transporters of a hemibiotrophic plant pathogen: functional variations and regulatory differences at different stages of infectionUlrike Lingner
Friedrich Alexander University Erlangen Nuremberg, Staudtstrasse 5, D 91058 Erlangen, Germany
J Biol Chem 286:20913-22. 2011..Phylogenetic studies revealed hexose transporters closely related to the five CgHXT proteins also in other pathogenic fungi suggesting conserved functions of these proteins during fungal pathogenesis...
- The CD28 signaling pathway regulates glucose metabolismKenneth A Frauwirth
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Immunity 16:769-77. 2002..These data suggest that CD28 costimulation functions to increase glycolytic flux, allowing T cells to anticipate energetic and biosynthetic needs associated with a sustained response...
- Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiencyT Lubke
Georg August Universitat Gottingen, Abteilung Biochemie II, Heinrich Düker Weg 12, Gottingen, Germany
Nat Genet 28:73-6. 2001..Following the recent recommendations for the nomenclature for CDG, this new type is classified as CDG-IIc (formerly LAD II)...
- An expression-driven approach to the prediction of carbohydrate transport and utilization regulons in the hyperthermophilic bacterium Thermotoga maritimaShannon B Conners
Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695 7905, USA
J Bacteriol 187:7267-82. 2005..maritima, the present study illustrates how expression-based strategies can be used for improving genome annotation in other microorganisms, especially those for which genetic systems are unavailable...
- Identification of the mstE gene encoding a glucose-inducible, low affinity glucose transporter in Aspergillus nidulansJosep V Forment
Instituto de Agroquimica y Tecnologia de Alimentos, Consejo Superior de Investigaciones Cientificas, Apartado de Correos 73, Burjassot, 46100 Valencia, Spain
J Biol Chem 281:8339-46. 2006..Deletion of mstE has no morphological phenotype but results in the absence of low affinity glucose uptake kinetics, the latter being substituted by a high affinity system...
- SUT2, a putative sucrose sensor in sieve elementsL Barker
Plant Physiology, Zentrum für Molekularbiologie der Pflanzen ZMBP, Universitat Tubingen, Germany
Plant Cell 12:1153-64. 2000....
- Sensors of extracellular nutrients in Saccharomyces cerevisiaeH Forsberg
Ludwig Institute for Cancer Research, Stockholm, Sweden
Curr Genet 40:91-109. 2001..The fact that yeast plasma membrane nutrient sensors have only recently been discovered reveals how little is understood regarding the molecular signals that enable eukaryotic cells to adapt to changing environments...
- Identification, purification, and molecular cloning of a putative plastidic glucose translocatorA Weber
Universitat zu Koln, Lehrstuhl Botanik II, Gyrhofstrasse 15, D 50931 Cologne, Germany
Plant Cell 12:787-802. 2000..This transporter, initially characterized more than 20 years ago, is closely related to the mammalian glucose transporter GLUT family and differs from all other plant hexose transporters that have been characterized to date...
- Asymmetric signal transduction through paralogs that comprise a genetic switch for sugar sensing in Saccharomyces cerevisiaeJeffrey Sabina
Department of Genetics, Washington University in Saint Louis, St Louis, Missouri 63108, USA
J Biol Chem 284:29635-43. 2009....
- Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathwaysLidia Tomas-Cobos
Instituto de Biomedicina de Valencia, Jaime Roig 11, 46010 Valencia, Spain
J Biol Chem 279:22010-9. 2004..Coordinated regulation of the two signaling pathways is required for expression of HXT1 by glucose and in response to osmostress...
- Validation of the hexose transporter of Plasmodium falciparum as a novel drug targetThierry Joet
Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, United Kingdom
Proc Natl Acad Sci U S A 100:7476-9. 2003..Our robust expression system conclusively validates PfHT as a novel drug target and is an important step in the development of novel antimalarials directed against membrane transport proteins...
- The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiaeKristy M Hawkins
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
J Biol Chem 281:13485-92. 2006..This result indicates that Gal1p may play a previously undescribed role in the stability of the GAL network response...
- Functional characterization of the alpha-glucoside transporter Sut1p from Schizosaccharomyces pombe, the first fungal homologue of plant sucrose transportersA Reinders
Plant Physiology, Zentrum für Molekularbiologie der Pflanzen ZMBP, Universitat Tubingen, Auf der Morgenstelle 1, D 72076 Tubingen, Germany
Mol Microbiol 39:445-54. 2001..These results indicate that, unlike S. cerevisiae, S. pombe utilizes maltose transporters derived from a common ancestor with the plant SUTs...
- Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptakeAimee L Edinger
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Mol Biol Cell 13:2276-88. 2002..These results suggest that growth factors control cellular growth and survival by regulating cellular access to extracellular nutrients in part by modulating the activity of Akt and mTOR...
- Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cellsB Thorens
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
Cell 55:281-90. 1988..Insulinoma cells express, inappropriately, the erythrocyte glucose transporter, and we suggest that this may be related to their inability to secrete insulin in response to elevations in glucose...
- Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicanaXiuhong Feng
Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
Mol Microbiol 71:369-81. 2009..These results underscore the importance of hexose transporters for the infectious stage of the parasite life cycle...
- Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type IbI Gerin
Laboratory of Physiological Chemistry, Institute of Cellular Pathology and University of Louvain, Brussels, Belgium
FEBS Lett 419:235-8. 1997..The encoded protein is therefore most likely the glucose 6-phosphate translocase that is functionally associated with glucose-6-phosphatase...
- Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocatorN Miura
Department of Physiological Chemistry, Tokyo Metropolitan Institute of Medical Science Rinshoken
J Biochem 120:236-41. 1996..To our knowledge, this is the first mammalian nucleotide-sugar translocator whose cDNA sequence has been described...
- Functional cloning of TUG as a regulator of GLUT4 glucose transporter traffickingJonathan S Bogan
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Nature 425:727-33. 2003..Our data suggest that TUG traps endocytosed GLUT4 and tethers it intracellularly, and that insulin mobilizes this pool of retained GLUT4 by releasing this tether...
- A genome-wide association study identifies KIAA0350 as a type 1 diabetes geneHakon Hakonarson
Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Nature 448:591-4. 2007..These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits...
- VvHT1 encodes a monosaccharide transporter expressed in the conducting complex of the grape berry phloemCéline Vignault
Unité Mixte de Recherches Centre National de la Recherche Scientifique 6161, Transport des Assimilats, Laboratoire de Physiologie, Biochimie et Biologie Moléculaire Végétales, Bâtiment Botanique, Universite de Poitiers, Poitiers, France
J Exp Bot 56:1409-18. 2005..The expression and functional properties of VvHT1 suggests that it retrieves the monosaccharides needed to provide the energy necessary for cell division and cell growth at an early stage of berry development...
- Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytesPablo Strobel
Molecular Nutrition Laboratory, Faculty of Biological Sciences, Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
Biochem J 386:471-8. 2005..Furthermore, the results suggest that GLUT transporters are involved in flavonoid incorporation into cells...
- Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: potential new anticancer target for curcuminAnissa Belkaid
Laboratoire d Oncologie Moleculaire, Departement de Chimie, Centre BIOMED, Universite du Quebec a Montreal, C P 8888, Succ Centre Ville, Montreal, Que, Canada H3C 3P8
FEBS Lett 580:3746-52. 2006..Targeting G6PT expression may provide a new mechanistic rationale for the action of chemopreventive drugs and lead to the development of new anti-cancer strategies...
- Site-directed alkylation of cysteine to test solvent accessibility of membrane proteinsLan Guan
Department of Physiology, University of California Los Angeles, Los Angeles, California, USA
Nat Protoc 2:2012-7. 2007..Gels are dried and exposed to a PhosphoImager screen for 1-5 d, and incorporation of radioactivity is visualized. Initial results can be obtained in 24 h...
- TOR kinase pathway and 14-3-3 proteins regulate glucose-induced expression of HXT1, a yeast low-affinity glucose transporterLidia Tomas-Cobos
Instituto de Biomedicina de Valencia CSIC, Jaime Roig 11, 46010 Valencia, Spain
Yeast 22:471-9. 2005..Inhibition of the TOR kinase pathway by rapamycin treatment abolishes HXT1 glucose induction. A possible involvement of PP2A protein phosphatase complex, through the Cdc55 B-subunit, in the glucose induction of HXT1 is also discussed...
- Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificityM Muraoka
Department of Physiological Chemistry, The Tokyo Metropolitan Institute of Medical Science Rinshoken, 18 22 Honkomagome 3 chome, Bunkyo ku, 113 8613, Tokyo, Japan
FEBS Lett 495:87-93. 2001..The possibility that this transporter participates in glucuronidation and/or chondroitin sulfate biosynthesis is discussed...
- Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycleKsenija Slavic
Centre for Infection and Immunity, Division of Clinical Sciences, St George s, University of London, London SW170RE, United Kingdom
Antimicrob Agents Chemother 55:2824-30. 2011..These data indicate that novel chemotherapeutic interventions that target PfHT may be active against liver and, to a lesser extent, transmission stages, in addition to blood stages...
- Sugar transporters from bacteria, parasites and mammals: structure-activity relationshipsA R Walmsley
Division of Infection and Immunity, University of Glasgow, UK
Trends Biochem Sci 23:476-81. 1998..Subtle distinctions in the function of these proteins can be related to particular amino acid residue substitutions...
- Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survivalJeffrey C Rathmell
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Mol Cell Biol 23:7315-28. 2003..The prevention of Bax activation by posttranscriptional regulation of glucose metabolism may, therefore, be a required aspect of the ability of Akt to maintain long-term cell survival in the absence of growth factors...
- Glucose uptake and catabolite repression in dominant HTR1 mutants of Saccharomyces cerevisiaeS Ozcan
Institut fur Mikrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
J Bacteriol 175:5520-8. 1993..Alternatively, some unidentified regulatory components of the glucose transport system may be involved in the generation or transmission of signals for glucose repression...
- Molecular basis for glucose-galactose malabsorptionErnest M Wright
Department of Physiology, UCLA School of Medicine, Los Angeles, CA 90095 1751, USA
Cell Biochem Biophys 36:115-21. 2002..We conclude that mutations in the SGLT1 gene are the cause of glucose-galactose malabsorption, and sugar transport is impaired mainly because the mutant proteins are either truncated or are not targeted properly to the cell membrane...
- The hexose transporters of Saccharomyces cerevisiae play different roles during enological fermentationKattie Luyten
UMR Sciences Pour 1 CEnologie, INRA ENSAM UMI, 2 place Viala, F 34060 Montpellier, France
Yeast 19:713-26. 2002..This work shows that the successful alcoholic fermentation of wine involves at least four or five hexose carriers, playing different roles at various stages in the fermentation cycle...
- Hxt-carrier-mediated glucose efflux upon exposure of Saccharomyces cerevisiae to excess maltoseMickel L A Jansen
Kluyver Laboratory of Biotechnology, Delft University of Technology, 2628 BC Delft, The Netherlands
Appl Environ Microbiol 68:4259-65. 2002..This is a relevant phenomenon for selection of maltose-constitutive strains for baking and brewing...
- Membrane Proteins of S. mansoni as Vaccine CandidatesDonald Harn; Fiscal Year: 2002..Data provided by these experiments will provide information about the mechanism of parasite killing and suggest whch formulations of SGTP4 will boost protective immunity...
- Novel TIRF microscopy analyzing trafficking & signaling at the cell cortexDerek Toomre; Fiscal Year: 2009..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
- Biology of IGFs in BoneThomas L Clemens; Fiscal Year: 2013..An understanding of this pathway should ultimately enable better management of diabetic veterans and conceivably lead to the design a single therapy, which can simultaneously target both osteoporosis and type 2 diabetes. ..
- Targeting GRK2 (BARK1) in Heart FailureWalter J Koch; Fiscal Year: 2013..abstract_text> ..
- THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTESKENAN RIFAT OMURTAG; Fiscal Year: 2013..This research will help us better understand how such environmental exposures may affect the male reproductive tract. ..
- The Role of Substrate Metabolism and Macrophage Activation in ObesityAmy Johnson; Fiscal Year: 2013....
- Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the corneaSharona E Gordon; Fiscal Year: 2013....
- CELLULAR REGULATION OF CLATHRIN ASSEMBLY AND FUNCTIONFrances M Brodsky; Fiscal Year: 2013....
- Effect of exposure to organochlorine compounds on the development of obesity andGEORGE E HOWELL; Fiscal Year: 2011..This research will determine if exposure to these compounds is a risk factor for development of T2D and if so will provide mechanisms through which these compounds precipitate this disease. ..
- Development of a mouse model of obesity in pregnancyThomas Jansson; Fiscal Year: 2009....
- Paternal Environmental Exposures and Reproductive Outcomes: A Comparison of in ViDEBORAH ANN HANSEN; Fiscal Year: 2013..In vivo and in vitro parameters include: a) 14.5 dpc placental and fetal weights, and crown to rump lengths;b) full term litter size, birth weights, and 5 week growth rates;and c) gross and microscopic structure. ..
- Phosphoprotein CDP138 regulates glucose metabolismZHEN YUE JIANG; Fiscal Year: 2013..Together, this project will provide valuable and novel insight into the molecular mechanisms by which CDP138 acts as a point of convergence between kinase activation and glucose transport. ..
- Biochemistry and Cell Biology of CHC22 ClathrinFrances M Brodsky; Fiscal Year: 2013..The proposed research will characterize the molecular mechanism of CHC22 function, its cellular regulation and its relationship to membrane traffic pathways that malfunction in diabetes. ..
- Role of Rab GAPs AS160 and Tbc1d1 in GLUT4 translocation and glucose homeostasisSusanna R Keller; Fiscal Year: 2013....
- Adiponectin regulates nutrient transport in the placentaTheresa L Powell; Fiscal Year: 2009..This research may lead to the development of intervention strategies to reduce birth weight in pregnancies of obese women, which will reduce the susceptibility to obesity in the next generation. ..
- Mechanisms of Membrane-Based Insulin Resistance &Therapeutic Reversal StrategiesJeffrey S Elmendorf; Fiscal Year: 2012..We have also identified means to protect against this derangement, and further investigation of the mechanisms involved will hopefully lead to new therapeutic strategies to curtail the accelerated expansion of the T2D population. ..
- The Role of Myosin in Vesicle TraffickingYashomati M Patel; Fiscal Year: 2010..The proposed research will provide critical information for understanding the molecular mechanism(s) involved in the development of in type 2 diabetes. ..
- Steroid regulation of glucose utilization during early pregnancy.ANTONINA I FROLOVA; Fiscal Year: 2010....
- Mechanisms of glucosensation mediating food choice behavior in DrosophilaMonica Dus; Fiscal Year: 2013..They will also provide mammalian researchers with conserved genes to use as molecular and neurochemical markers in future studies of glucosensation, feeding, and disease. ..
- Pioglitazone & Exercise Effects on Older Aldults with MCI and Metabolic SyndromeRobert S Schwartz; Fiscal Year: 2010..This study will assess novel metabolic treatments for patients with both MCI and MS, with the aim of delaying the progression of these patients to dementia. ..
- The role of exposure to bioaccumulative organochlorine compounds on the occurrencGEORGE E HOWELL; Fiscal Year: 2010..If so, the present study will provide mechanisms through which these compounds promote this disease and will establish exposure to certain organochlorine compounds as a risk factor for the development of type 2 diabetes. ..
- Sweet taste receptors and glucose metabolism in healthy and T2DM humansKaren L Teff; Fiscal Year: 2012..Our overall hypothesis is that in healthy subjects, the STR receptor is involved in the regulation of post-prandial glucose metabolism and GLP levels but in T2DM, the STR receptor is unresponsive to activation or inhibition ..
- Engineering an in vitro model of adipose tissue formation and metabolismKyongbum Lee; Fiscal Year: 2010..Prospectively, these insights could lead to novel metabolic targets or nutritional strategies to control diseases and disorders resulting from or related to excessive AT expansion, including obesity and type 2 diabetes. ..
- GLUT8 Overexpression in CardioprotectionMaureen J Charron; Fiscal Year: 2010..Preliminary studies in this proposal show that hearts overexpressing the GLUT8 glucose transporter are resistant to ischemic injury. The therapeutic potential of GLUT8 overexpression in diabetic models will be assessed in this proposal. ..
- Candida albicans Epithelial Cell Interactions and Oropharyngeal DiseaseScott G Filler; Fiscal Year: 2013..albicans Cht2 and Hgt12 govern epithelial cell invasion, damage, and virulence;and 3) use overexpression-rescue and null mutant analysis to identify additional target genes of Tpk2 that mediate epithelial cell invasion and damage. ..
- Insulin Action on GLUT4 and FOXO1 in the BrainGarrett Heinrich; Fiscal Year: 2012..This project studies the function of neurons in the brain that express the glucose transporter GLUT4 and gene transcription factor FOXO1 and how insulin action in those neurons maintains peripheral glucose homeostasis. ..
- Refined Fructose Promotes Pancreatic Cancer GrowthAnthony P Heaney; Fiscal Year: 2011..Our identification of GLUT-5 as a key in the molecular mechanism by which pancreatic cancer cells preferentially utilize fructose may pave the way to novel therapeutic approaches targeting GLUT-5 action in pancreatic cancer. ..
- GLUTS AND GLUCOSE TRANSPORT IN THE MOUSE BLASTOCYSTKelle H Moley; Fiscal Year: 2012..By modulating the rate of autophagy during the preimplantation period in these models and then transferring these embryos into surrogate mice, the outcomes of these manipulations are determined. ..
- Mechanisms of glucose mediated cardiac mitochondrial dysfunctionADAM RAYMOND WENDE; Fiscal Year: 2013..Collectively, the completion of these studies will provide fundamental insights into the mechanistic basis for glucose in the development of diabetic cardiomyopathy and mitochondrial dysfunction. ..
- Mechanisms of glucose mediated cardiac mitochondrial dysfunctionADAM RAYMOND WENDE; Fiscal Year: 2013..Collectively, the completion of these studies will provide fundamental insights into the mechanistic basis for glucose in the development of diabetic cardiomyopathy and mitochondrial dysfunction. ..
- Cytoskeletal Regulation of Erythrocyte Glucose Transporter-1Athar H Chishti; Fiscal Year: 2012..abstract_text> ..
- Genetics of Obesity in Yup'ik EskimosBERT BRANDON BOYER; Fiscal Year: 2011..abstract_text> ..
- Connecting metabolic stress and cell physiology in Escherichia coliGREGORY ROSS RICHARDS; Fiscal Year: 2012....
- GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETESBarbara B Kahn; Fiscal Year: 2013..These studies will elucidate novel mechanisms underlying the inter-tissue communication that plays an important role in the pathogenesis of type 2 diabetes. ..
- Functional mapping of SNARE-dependent trafficking and fusionJeffrey E Pessin; Fiscal Year: 2013..Thus, understanding the mechanism for this translocation process and the ability of insulin to increase glucose uptake are essentially process for the maintenance of normal glucose homeostasis. 1 ..
- PGC-1alpha and GABAergic Dysfunction in Huntington DiseaseRita Marie Cowell; Fiscal Year: 2013..These studies will test whether transcriptional pathways that control mitochondrial function and calcium homeostasis in interneurons have potential as targets for treatment of patients with HD. ..
- Role of SGLT3 in diabetes-mediated increased renal sodium reabsorptionNiloofar M Tabatabai; Fiscal Year: 2013..The proposed in vitro and in vivo studies are designed to investigate the role of SGLT3 as a novel glucose-stimulated Na+ transporter that may play role in the enhanced Na+ reabsorption in diabetes. ..
- CHC22 CLATHRIN FUNCTION IN HUMAN GLUCOSE METABOLISMFRANCES BRODSKY; Fiscal Year: 2009..The research proposed here will establish novel characteristics of human glucose homeostasis and will enable development of better animal models for studying its dysfunction in diabetes. ..
- Functional Characterization of Leishmania TransportersScott M Landfear; Fiscal Year: 2010..Overall, this proposal will provide a detailed biochemical and genetic dissection of glucose transporter function and the essential role of these permeases in the parasite life cycle. ..
- Adipose Tissue Branched-Chain Amino Acid Metabolism and Glucose HomeostasisMark A Herman; Fiscal Year: 2010..The ultimate goal is for the applicant to become an independent investigator. ..
- Molecular motors in cell biologyYale E Goldman; Fiscal Year: 2013..We anticipate that the proposed work will take us significantly further toward our goal of understanding motility in the normal and pathological function of cells. ..
- Gene and environment interaction and insulin resistanceRaquel Villegas; Fiscal Year: 2013..Findings from this study can be used to aid in the prevention of T2D, since insulin resistance is a reversible condition. ..
- Development of Assay for High Throughput Screen of Parasite Glucose TransporterScott M Landfear; Fiscal Year: 2010..Since glucose is an essential nutrient for these parasites, such compounds would kill the parasite and could act as novel drugs for treatment of the diseases they cause. ..
- Evaluation of BRAF-inhibitor induced alterations in glucose metabolismNicholas Theodosakis; Fiscal Year: 2013..New discoveries in the mechanisms underpinning metabolic changes may also suggest new metabolically-based combination therapies aimed at overcoming vemurafenib resistance. ..
- INSULIN REGULATED MEMBRANE TRAFFICKINGTimothy E McGraw; Fiscal Year: 2013..The results of this ambitious and comprehensive study will significantly advance our understanding of the molecular mechanisms controlling the trafficking of Glut4 between the plasma membrane and endomembrane compartments of adipocytes. ..
- How glucose transporter structure affects its functionAnthony Carruthers; Fiscal Year: 2013..abstract_text> ..
- Selective Inhibitors of the Hexose Transporter from African TrypansomesScott Landfear; Fiscal Year: 2013..Kip Guy, who operates an internationally renowned compound screening and pharmaceutical chemistry facility at St. Jude and who has a strong track record of screening for anti-parasitic compounds. ..
- Is GLUT1 required for tumor growth and the Warburg Effect?Steven M Anderson; Fiscal Year: 2013....
- Flagellar targeting and sensory function of a glucose transporter in L. mexicana.KHOA DANG TRAN; Fiscal Year: 2013..These studies aim to elucidate a flagellar targeting pathway that likely operates for multiple membrane proteins in Leishmania and related trypanosomes, as well as identify a flagellar specific sensory role for this glucose transporter. ..
- SUBCELLULAR LOCALIZATION OF PI 3-KINASE SIGNALINGMichael P Czech; Fiscal Year: 2011..With Project 3, we will also define the membrane topographies and structures of molecular complexes that act on GLUT4-containing vesicles in the TIRF zone, and elucidate the mechanisms involved in their actions. ..
- Investigating the Mechanism by which Glut4 Storage Vesicle (GSV) Fusion is RegulaMATTHEW MOLSKI; Fiscal Year: 2013..GSV fusion, the active SNAREs are syntaxin 4, SNAP-23, and VAMP2. Additional proteins are known to regulate fusion by directly interacting with the SNAREs, including Munc18c and Doc2b, but ..
- Targeting and Function of Golgi Membrane ProteinsCarolyn E Machamer; Fiscal Year: 2011..The proposed experiments on golgin-160 will add to our understanding of cargo delivery to the cell surface and to the role of the Golgi complex in transducing stress signals to the rest of the cell. ..
- Role of TUG in the Formation of Insulin-Responsive GLUT4 VesiclesCharisse Orme; Fiscal Year: 2011..It is anticipated that the results of this work will have importance for understanding how GLUT4 glucose transporters are properly sorted from internal membranes into the insulin responsive compartment. ..
- Defining the Role of Boi1/Boi2 in the Coordination of Actin Polarity and PolarizeLEAH JOY WATSON; Fiscal Year: 2013..Understanding the basic mechanism involved in cell polarity thus can improve diagnostic and preventative approaches to human disease. ..
- Glucose Transport in Regulation of T Cell Activation and InflammationJeffrey C Rathmell; Fiscal Year: 2012....
- Noninvasive neonatal glucose monitorROSE MARIE VISCARDI; Fiscal Year: 2012..The POC device will be tested only on standard glucose solutions and the porcine skin model. Phase II will involve testing of the POC device in the neonatal intensive care unit (NICU). ..
- Epilepsy in Primary Cerebral Energy FailureLEVI BOGACZ GOOD; Fiscal Year: 2010..The principal aim of this project is to understand and to measure the dependence of brain excitability on brain energy metabolism by studying both normal and disease states. ..
- Modulation of neural function in energy failureJUAN MANUEL PASCUAL; Fiscal Year: 2013..In summary, we expect that this proposal will help define G1D as a synaptic disorder and render it amenable to excitable or metabolic target modification. ..
- Regulatory Mechanisms of GLUT4 ExocytosisJingshi Shen; Fiscal Year: 2013..The findings will also shed light upon the diseases associated with glucose imbalances such as insulin resistance and type 2 diabetes, and will facilitate the development of novel strategies for therapeutic intervention. ..
- TUG-mediated GLUT4 glucose transporter trafficking and regulation by post-translaJONATHAN PHILIP BELMAN; Fiscal Year: 2012..These are important questions for type 2 diabetes, and may also have more fundamental significance for cell biology and physiology. ..
- Regulatory Mechanisms of GLUT4 ExocytosisJingshi Shen; Fiscal Year: 2012..The findings will also shed light upon the diseases associated with glucose imbalances such as insulin resistance and type 2 diabetes, and will facilitate the development of novel strategies for therapeutic intervention. ..
- REGULATION OF PROTEIN TRAFFICKING IN ADIPOCYTESMike M Mueckler; Fiscal Year: 2013..It is directly relevant to understanding the molecular mechanisms involved in the regulation of whole body glucose homeostasis and its derangement in insulin resistant states such as diabetes, obesity, and metabolic syndrome. ..
- High content screening assay for activators of glucose transporter GLUT4ZHEN YUE JIANG; Fiscal Year: 2010..We propose to develop a high throughput screening assay to identify potential small molecules that activate glucose transport system and improve insulin sensitivity, which may promote new avenues for treatment of diabetes. ..
- Vascular smooth muscle apoptosis prevention by glucoseFrank Brosius; Fiscal Year: 2005..We will also determine the mitochondrial metabolic effects that are most critical to both hypoxia-induced apoptosis and glucose protection in VSMCs. ..
- PERINATAL METABOLIC STRESS AND BRAIN GLUCOSE TRANSPORTSUSAN VANNUCCI; Fiscal Year: 1999..The results of this study should help elucidate the mechanisms by which the immature brain responds to injury and may provide opportunities for intervention in these, and other, perinatal diseases. ..
- REGULATION OF GLUT1 GENE EXPRESSION BY HYPOXIAFaramarz Ismail Beigi; Fiscal Year: 2001....
- SURGERY OF THE PANCREAS--EFFECTS ON GLUCOSE METABOLISMDana Andersen; Fiscal Year: 1999....
- Role of Rab GAPs AS160 and Tbc1d1 in GLUT4 translocation and glucose homeostasisSUSANNA KELLER; Fiscal Year: 2009..It will further provide crucial information towards the validation of AS160 and Tbc1d1 as drug targets to improve glucose homeostasis and prevent ensuing complications of insulin resistance. ..
- Glucose Meatbolism in the Human OvaryMAUREEN CHARRON; Fiscal Year: 2004..These observations are hoped to have relevance for understanding of basic reproductive physiology and the mechanism of reproductive dysfunction in PCOS. ..
- PHOSPHORYLATION OF THE GLUCOSE TRANSPORTER BY INSULINDavid Sacks; Fiscal Year: 1991..These studies should add considerably to our knowledge of the molecular mechanism by which insulin stimulates glucose transport...
- GLUCOSE-DEPENDENT GLUT-1 EXPRESSION IN EMBRYONIC HEARTIDA WASHINGTON; Fiscal Year: 2003....
- PROTEIN ENGINEERED GLUCOSE SENSORGovind Rao; Fiscal Year: 1999..We believe that a superior reagentless glucose sensor can be made and can have a significant impact on the ability to move towards an indwelling glucose monitoring system. ..
- Insulin Signaling to GLUT4 and the Actin CytoskeletonMichael Czech; Fiscal Year: 2007..Together, these experiments will clarify the role of Myo1c and the actin cytoskeleton in GLUT4 regulation by insulin. ..
- BIOLOGY OF THE BLOOD BRAIN BARRIERWilliam Pardridge; Fiscal Year: 1999..Extensive utilization of this Core will provide a common vehicle for interaction amongst the five projects, as well as for extension of blood-brain barrier research to the biochemical and molecular biological level. ..
- GLUCOSE TRANSPORTER EXPRESSION IN TRANSGENIC MICEANN OLSON; Fiscal Year: 1999..Understanding this mechanism will provide useful insight into the mechanisms by which GLUT4 gene expression occurs in vivo. ..
- REGULATION OF MEMBRANE TRANSPORT BY THYROID HORMONERichard Haber; Fiscal Year: 1993....
- SLC2A9, A Candidate ER GLUT in Normal and Cancer CellsJeffrey Moley; Fiscal Year: 2002..Identification of SLC2A9 as the endoplasmic reticulum glucose transporter will improve understanding of GSDs, and of glucose metabolism in benign and malignant tissues. ..