monosaccharide transport proteins

Summary

Summary: A large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES.

Top Publications

  1. pmc A versatile monosaccharide transporter that operates in the arbuscular mycorrhizal fungus Glomus sp is crucial for the symbiotic relationship with plants
    Nicole Helber
    Plant Microbial Interactions Group, Karlsruhe Institute of Technology, Hertzstrasse 16, D 76187 Karlsruhe, Germany
    Plant Cell 23:3812-23. 2011
  2. pmc Molecular identification and physiological characterization of a novel monosaccharide transporter from Arabidopsis involved in vacuolar sugar transport
    Alexandra Wormit
    Pflanzenphysiologie, Technische Universitat Kaiserslautern, D 67653 Kaiserslautern, Germany
    Plant Cell 18:3476-90. 2006
  3. ncbi A previously unknown maltose transporter essential for starch degradation in leaves
    Totte Niittyla
    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, UK
    Science 303:87-9. 2004
  4. ncbi CAP defines a second signalling pathway required for insulin-stimulated glucose transport
    C A Baumann
    Department of Physiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Nature 407:202-7. 2000
  5. ncbi The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin
    Mayumi Inoue
    Life Sciences Institute, Departments of Internal Medicine and Physiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Nature 422:629-33. 2003
  6. ncbi Glucose-sensing mechanisms in eukaryotic cells
    F Rolland
    Laboratorium voor Moleculaire Celbiologie, Instituut voor Plantkunde en Microbiologie, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B-3001 Leuven-Heverlee, Flanders, Belgium
    Trends Biochem Sci 26:310-7. 2001
  7. pmc Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY
    Osman Mirza
    Department of Biological Sciences, Membrane Protein Crystallography Group, Imperial College London, London, UK
    EMBO J 25:1177-83. 2006
  8. ncbi Glucose uptake kinetics and transcription of HXT genes in chemostat cultures of Saccharomyces cerevisiae
    J A Diderich
    E C Slater Institute, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
    J Biol Chem 274:15350-9. 1999
  9. ncbi Families of transmembrane sugar transport proteins
    M H Saier
    Department of Biology, University of California at San Diego, La Jolla, CA 92093 0116, USA
    Mol Microbiol 35:699-710. 2000
  10. pmc Roles of multiple glucose transporters in Saccharomyces cerevisiae
    C H Ko
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208
    Mol Cell Biol 13:638-48. 1993

Detail Information

Publications383 found, 100 shown here

  1. pmc A versatile monosaccharide transporter that operates in the arbuscular mycorrhizal fungus Glomus sp is crucial for the symbiotic relationship with plants
    Nicole Helber
    Plant Microbial Interactions Group, Karlsruhe Institute of Technology, Hertzstrasse 16, D 76187 Karlsruhe, Germany
    Plant Cell 23:3812-23. 2011
    ..These results imply that the sugar uptake system operating in this symbiosis is more complex than previously anticipated...
  2. pmc Molecular identification and physiological characterization of a novel monosaccharide transporter from Arabidopsis involved in vacuolar sugar transport
    Alexandra Wormit
    Pflanzenphysiologie, Technische Universitat Kaiserslautern, D 67653 Kaiserslautern, Germany
    Plant Cell 18:3476-90. 2006
    ..Our results indicate that TMT1 is involved in vacuolar monosaccharide transport and plays a major role during stress responses...
  3. ncbi A previously unknown maltose transporter essential for starch degradation in leaves
    Totte Niittyla
    Department of Metabolic Biology, John Innes Centre, Norwich NR4 7UH, UK
    Science 303:87-9. 2004
    ..The severe mex1 phenotype demonstrates that MEX1is the predominant route of carbohydrate export from chloroplasts at night. Homologous genes in plants including rice and potato indicate that maltose export is of widespread significance...
  4. ncbi CAP defines a second signalling pathway required for insulin-stimulated glucose transport
    C A Baumann
    Department of Physiology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109, USA
    Nature 407:202-7. 2000
    ..Thus, localization of the Cbl-CAP complex to lipid rafts generates a pathway that is crucial in the regulation of glucose uptake...
  5. ncbi The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin
    Mayumi Inoue
    Life Sciences Institute, Departments of Internal Medicine and Physiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Nature 422:629-33. 2003
    ..So, the exocyst might have a crucial role in the targeting of the Glut4 vesicle to the plasma membrane, perhaps directing the vesicle to the precise site of fusion...
  6. ncbi Glucose-sensing mechanisms in eukaryotic cells
    F Rolland
    Laboratorium voor Moleculaire Celbiologie, Instituut voor Plantkunde en Microbiologie, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B-3001 Leuven-Heverlee, Flanders, Belgium
    Trends Biochem Sci 26:310-7. 2001
    ....
  7. pmc Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY
    Osman Mirza
    Department of Biological Sciences, Membrane Protein Crystallography Group, Imperial College London, London, UK
    EMBO J 25:1177-83. 2006
    ..Thus, substrate induces formation of the sugar-binding site, as well as the initial step in H+ transduction...
  8. ncbi Glucose uptake kinetics and transcription of HXT genes in chemostat cultures of Saccharomyces cerevisiae
    J A Diderich
    E C Slater Institute, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
    J Biol Chem 274:15350-9. 1999
    ..At high dilution rates, however, the estimated glucose transport capacity was too low to account for the in situ glucose consumption rate...
  9. ncbi Families of transmembrane sugar transport proteins
    M H Saier
    Department of Biology, University of California at San Diego, La Jolla, CA 92093 0116, USA
    Mol Microbiol 35:699-710. 2000
    ..This review provides a comprehensive guide to the diversity of carriers that mediate the transport of sugar-containing molecules across cell and organellar membranes...
  10. pmc Roles of multiple glucose transporters in Saccharomyces cerevisiae
    C H Ko
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208
    Mol Cell Biol 13:638-48. 1993
    ..HXT1 and HXT3 are differentially regulated. HXT1::lacZ is maximally expressed during exponential growth whereas HXT3::lacZ is maximally expressed after entry into stationary phase...
  11. pmc Expression of high-affinity glucose transport protein Hxt2p of Saccharomyces cerevisiae is both repressed and induced by glucose and appears to be regulated posttranslationally
    D L Wendell
    Department of Viticulture and Enology, University of California, Davis 95616 8749
    J Bacteriol 176:3730-7. 1994
    ..Similarly, Hxt2p was found to be expressed under low-glucose conditions in an snf3 mutant which does not display high-affinity uptake. This finding suggests that SNF3 may be involved in the posttranslational regulation of Hxt2p...
  12. pmc Lactose permease and the alternating access mechanism
    Irina Smirnova
    Department of Physiology and Department of Microbiology, University of California, Los Angeles, California 90095, United States
    Biochemistry 50:9684-93. 2011
    ..Evidence is also presented indicating that opening of the periplasmic cavity is probably the limiting step for binding and perhaps transport...
  13. pmc High-copy suppression of glucose transport defects by HXT4 and regulatory elements in the promoters of the HXT genes in Saccharomyces cerevisiae
    G Theodoris
    Department of Viticulture and Enology, University of California, Davis 95616
    Genetics 137:957-66. 1994
    ..The promoters of SNF3 and of other glycolytic genes examined did not suppress snf3 in multicopy. Suppression of snf3 by DDSE is dependent on the presence of either HXT2 or HXT3...
  14. pmc Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression
    S Ozcan
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 93:12428-32. 1996
    ..Thus, the Rgt2p and Snf3p glucose transporters appear to act as glucose receptors that generate an intracellular glucose signal, suggesting that glucose signaling in yeast is a receptor-mediated process...
  15. ncbi Exogenous inositol and genes responsible for inositol transport are required for mating and sporulation in Shizosaccharomyces pombe
    C Niederberger
    Institute of General Microbiology, University of Bern, Switzerland
    Curr Genet 33:255-61. 1998
    ..The itr2 gene is essential for cell growth and its mRNA level is repressed by glucose. Mutant IM49 is also complemented by a multicopy suppressor gene (itr1) which codes for a putative hexose transporter with unknown substrate specifity...
  16. ncbi A putative high affinity hexose transporter, hxtA, of Aspergillus nidulans is induced in vegetative hyphae upon starvation and in ascogenous hyphae during cleistothecium formation
    Huijun Wei
    Department of Microbiology, University of Marburg and Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, Marburg D 35043, Germany
    Fungal Genet Biol 41:148-56. 2004
    ..We found hxtA(p)::sgfp expression in developing cleistothecia specifically in ascogenous hyphae and propose that HxtA is a high affinity glucose transporter involved in sugar metabolism during sexual development...
  17. ncbi Haploid genetic screens in human cells identify host factors used by pathogens
    Jan E Carette
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 326:1231-5. 2009
    ..This approach has both conceptual and practical parallels with genetic approaches in haploid yeast...
  18. ncbi Role of Akt/protein kinase B in metabolism
    Eileen L Whiteman
    Dept Medicine and Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 415 Curie Blvd, 322 Clinical Research Building, Philadelphia, PA 19104, USA
    Trends Endocrinol Metab 13:444-51. 2002
    ....
  19. ncbi Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    K T Uysal
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 389:610-4. 1997
    ..These results indicate that TNF-alpha is an important mediator of insulin resistance in obesity through its effects on several important sites of insulin action...
  20. ncbi The alternating-access mechanism of MFS transporters arises from inverted-topology repeats
    Sebastian Radestock
    Computational Structural Biology Group, Max Planck Institute of Biophysics, Max von Laue Str 3, 60438 Frankfurtam Main, Germany
    J Mol Biol 407:698-715. 2011
    ..More fundamentally, our model demonstrates that inverted-topology repeats provide the foundation for the alternating-access mechanisms of MFS transporters...
  21. pmc Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiae
    S Ozcan
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    EMBO J 17:2566-73. 1998
    ..These results support the idea that yeast senses glucose using two modified glucose transporters that serve as glucose receptors...
  22. ncbi Glut-1 and hexokinase expression: relationship with 2-fluoro-2-deoxy-D-glucose uptake in A431 and T47D cells in culture
    L Aloj
    Nuclear Medicine Department, Clinical Center, NIH, Bethesda, Maryland 20892 1180, USA
    Cancer Res 59:4709-14. 1999
    ..Our data indicate that in these cultured cells, FDG uptake correlates better with FDG phosphorylating activity of mitochondrial preparations rather than the level of expression of the Glut-1 or hexokinase I and II genes...
  23. pmc Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose
    S Ozcan
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110
    Mol Cell Biol 15:1564-72. 1995
    ..Thus, the glucose repression and glucose induction mechanisms share some of the same components and may share the same primary signal generated from glucose...
  24. pmc Sugar binding induces an outward facing conformation of LacY
    Irina Smirnova
    Department of Physiology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:16504-9. 2007
    ..The DEER measurements in conjunction with molecular modeling based on the x-ray structure provide strong support for the alternative access model and reveal a structure for the outward-facing conformer of LacY...
  25. ncbi Structure and mechanism of the lactose permease of Escherichia coli
    Jeff Abramson
    Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK
    Science 301:610-5. 2003
    ..We propose a possible mechanism for lactose/proton symport (co-transport) consistent with both the structure and a large body of experimental data...
  26. pmc Transcriptomic and metabolite analyses of Cabernet Sauvignon grape berry development
    Laurent G Deluc
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Nevada 89557 0014, USA
    BMC Genomics 8:429. 2007
    ....
  27. ncbi GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes
    A E Stenbit
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Med 3:1096-101. 1997
    ..The male GLUT4 +/- mice represent a good model for studying the development of NIDDM without the complications associated with obesity...
  28. ncbi Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B
    Sun Sik Bae
    Howard Hughes Medical Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 278:49530-6. 2003
    ....
  29. pmc Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules
    Sabina Semiz
    Program in Molecular Medicine, 373 Plantation Street, University of Massachusetts Medical School, Worcester 01605, USA
    EMBO J 22:2387-99. 2003
    ..This insulin signaling pathway regulating KIF5B function appears to be required for GLUT4 translocation to the plasma membrane...
  30. ncbi Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix
    R Airley
    Cancer Research Campaign Experimental Radiation Oncology Group, Paterson Institute for Cancer Research
    Clin Cancer Res 7:928-34. 2001
    ..022) but did not significantly effect disease-free or recurrence-free survival. These findings suggest that Glut-1 be an intrinsic marker of hypoxia that can easily be applied in a clinical setting...
  31. ncbi Cloning and characterization of seven cDNAs for hyperosmolarity-responsive (HOR) genes of Saccharomyces cerevisiae
    T Hirayama
    Laboratory of Plant Molecular Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Mol Gen Genet 249:127-38. 1995
    ..In addition, Hog1p, one of the MAP kinases in yeast, appeared to be involved in the regulation of expression of HOR genes, although its function seemed to be insufficient for the overall regulation of expression of these genes...
  32. pmc Transport activity of rice sucrose transporters OsSUT1 and OsSUT5
    Ye Sun
    Department of Plant Biology, University of Minnesota, 250 Biological Sciences Center, St Paul, MN 55108 USA
    Plant Cell Physiol 51:114-22. 2010
    ..In conclusion, differences in transport activity between OsSUT1 and OsSUT5 indicate that type II SUTs have a range of transport activities that are tuned to their function in the plant...
  33. ncbi GLUT-1 expression in ovarian carcinoma: association with survival and response to chemotherapy
    G Cantuaria
    Department of Obstetrics and Gynecology, University of Miami, Jackson Memorial Hospital, Miami, Florida, USA
    Cancer 92:1144-50. 2001
    ..The objective of this study was to investigate the association of GLUT-1 with response to chemotherapy and outcome in patients with ovarian carcinoma...
  34. pmc Polarized distribution of glucose transporter isoforms in Caco-2 cells
    D S Harris
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110
    Proc Natl Acad Sci U S A 89:7556-60. 1992
    ..The amino acid sequence identity (57%) and structural conservation between GLUT1 and GLUT3 may make these transporters an ideal model system for examining the molecular basis for polarized sorting of membrane proteins...
  35. pmc A Golgi-localized hexose transporter is involved in heterotrimeric G protein-mediated early development in Arabidopsis
    Helen X Wang
    Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Mol Biol Cell 17:4257-69. 2006
    ..SGB1 is shown here to be a Golgi-localized hexose transporter and acts genetically with AGB1 in early seedling development...
  36. ncbi The osmotolerant fructophilic yeast Zygosaccharomyces rouxii employs two plasma-membrane fructose uptake systems belonging to a new family of yeast sugar transporters
    Maria José Leandro
    CBAA, Instituto Superior de Agromonia, TUL, 1349 017 Lisboa, Portugal
    Microbiology 157:601-8. 2011
    ....
  37. ncbi Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis
    Ilse A Hoppenbrouwers
    Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands
    J Hum Genet 54:676-80. 2009
    ..Several of these risk genes, including CD58 and CLEC16A, are shared by different autoimmune diseases. Fine mapping studies will be needed to determine the functional contributions to distinct autoimmune phenotypes...
  38. ncbi Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human
    Shuichi Hiraoka
    Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Nat Med 13:1363-7. 2007
    ..Our findings highlight the crucial role of NSTs in proteoglycan function and cartilage metabolism, thus revealing a new paradigm for skeletal disease and glycobiology...
  39. pmc Glucose uptake in Trichoderma harzianum: role of gtt1
    Jesús Delgado-Jarana
    Departamento de Genetica, Facultad de Biologia, 41012 Seville, Spain
    Eukaryot Cell 2:708-17. 2003
    ..The cloning of the first filamentous ascomycete glucose transporter is the first step in elucidating the mechanisms of glucose uptake and carbon repression in aerobic fungi...
  40. pmc Manipulating phospholipids for crystallization of a membrane transport protein
    Lan Guan
    Department of Physiology, University of California, Los Angeles, CA 90095 1662, USA
    Proc Natl Acad Sci U S A 103:1723-6. 2006
    ..Thus, it is likely that manipulation of PL is a good strategy for predominantly hydrophobic membrane proteins like LacY...
  41. ncbi Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae
    J Nikawa
    Department of Biochemistry, Gunma University School of Medicine, Maebashi, Japan
    J Biol Chem 266:11184-91. 1991
    ..Northern blot analysis showed that ITR1 mRNA was much more abundant than ITR2 mRNA. The previously isolated myo-inositol transport mutant was determined to be defective in ITR1...
  42. pmc Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry
    Adam B Weinglass
    Department of Physiology, Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095 1662, USA
    EMBO J 22:1467-77. 2003
    ..The approach demonstrates that mass spectrometry can provide a powerful means of analyzing ligand interactions with integral membrane proteins...
  43. pmc How the Rgt1 transcription factor of Saccharomyces cerevisiae is regulated by glucose
    Jeffrey A Polish
    Department of Genetics, Washington University, Saint Louis, Missouri 63110, USA
    Genetics 169:583-94. 2005
    ..Glucose induces HXT1 gene expression by causing Mth1 degradation, allowing Rgt1 phosphorylation, and leading to the intramolecular interaction that inhibits DNA binding of Rgt1...
  44. ncbi Fsy1, the sole hexose-proton transporter characterized in Saccharomyces yeasts, exhibits a variable fructose:H(+) stoichiometry
    Jorge Anjos
    Centro de Recursos Microbiológicos, Departamento de Ciências da Vida, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829 516 Caparica, Portugal
    Biochim Biophys Acta 1828:201-7. 2013
    ....
  45. ncbi Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cells
    L J Foster
    Cell Biology Programme, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Am J Physiol Cell Physiol 279:C877-90. 2000
    ..Potential modes of regulation of this process are discussed, including SNARE phosphorylation and interaction with the cytoskeleton...
  46. ncbi Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic flux
    E Reifenberger
    Institut für Milrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Mol Microbiol 16:157-67. 1995
    ..These results demonstrate that individual HXT proteins can function independently as hexose transporters, and that most of the metabolically relevant HXT transporters from S. cerevisiae have been identified...
  47. pmc A heritable switch in carbon source utilization driven by an unusual yeast prion
    Jessica C S Brown
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Genes Dev 23:2320-32. 2009
    ....
  48. pmc A glucose transport protein expressed predominately in insulin-responsive tissues
    M J Charron
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142
    Proc Natl Acad Sci U S A 86:2535-9. 1989
    ..This GT-like cDNA is the fourth member of the mammalian GT-related gene family identified to date. We propose that it encodes an insulin-sensitive GT...
  49. ncbi Glut 1 expression in transitional cell carcinoma of the urinary bladder is associated with poor patient survival
    M Younes
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Anticancer Res 21:575-8. 2001
    ..0109), but showed no significant difference in the incidence of nodal metastasis (p = 0.4258). Our results suggest that Glut1 expression in TCCB is a marker of aggressive biologic potential in patients undergoing cystectomy...
  50. pmc Functional expression and characterization of the Trypanosoma brucei procyclic glucose transporter, THT2
    M P Barrett
    Universite de Bordeaux II, France
    Biochem J 312:687-91. 1995
    ..THT2 expressed in CHO cells behaved as a facilitated transporter, and was unaffected by FCCP or KCN over the whole substrate concentration range tested...
  51. pmc Combinatorial control of gene expression by the three yeast repressors Mig1, Mig2 and Mig3
    Jakub Orzechowski Westholm
    The Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, SE 751 24 Uppsala, Sweden
    BMC Genomics 9:601. 2008
    ..We have used microarrays to study global gene expression in all possible combinations of mig1, mig2 and mig3 deletion mutants...
  52. pmc Residues gating the periplasmic pathway of LacY
    Yonggang Zhou
    Department of Physiology, University of California, Los Angeles, CA 90095 7327, USA
    J Mol Biol 394:219-25. 2009
    ..The data indicate that residues Ile40 and Asn245 play a primary role in gating the periplasmic cavity and provide further support for the alternating-access model...
  53. ncbi The glucose-6-phosphate transporter is a phosphate-linked antiporter deficient in glycogen storage disease type Ib and Ic
    Shih Yin Chen
    Section on Cellular Differentiation, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1830, USA
    FASEB J 22:2206-13. 2008
    ..Taken together, our results suggest that G6PT has a dual role as a G6P and a P(i) transporter and that GSD-Ib and GSD-Ic are deficient in the same G6PT gene...
  54. pmc A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs
    Martin Blume
    Department of Molecular Parasitology, Humboldt University, Berlin, Germany
    FASEB J 25:1218-29. 2011
    ..This work provides a platform to facilitate the development of drugs against malaria, and it suggests a disease-control aspect by reducing parasite transmission...
  55. pmc Mutational analysis of the SNF3 glucose transporter of Saccharomyces cerevisiae
    L Marshall-Carlson
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Mol Cell Biol 10:1105-15. 1990
    ..We also report the genetic mapping of the SNF3 locus on the left arm of chromosome IV...
  56. pmc Structural determination of wild-type lactose permease
    Lan Guan
    Department of Physiology, University of California, Los Angeles, CA 90095 1662, USA
    Proc Natl Acad Sci U S A 104:15294-8. 2007
    ..Because the inward-facing conformation represents the lowest free-energy state, the rate-limiting step for transport may be the conformational change leading to the outward-facing conformation...
  57. ncbi Genotype/phenotype correlation in glycogen storage disease type 1b: a multicentre study and review of the literature
    Daniela Melis
    Dipartimento di Pediatria, Universita Federico II, Via Sergio Pansini 5, 80131 Napoli, Italy
    Eur J Pediatr 164:501-8. 2005
    ..In three patients no mutations were detected...
  58. ncbi Inactivation of the glucose 6-phosphate transporter causes glycogen storage disease type 1b
    H Hiraiwa
    Heritable Disorders Branch, NICHD, National Institutes of Health, Bethesda, Maryland, 20892, USA
    J Biol Chem 274:5532-6. 1999
    ....
  59. ncbi Mth1 receives the signal given by the glucose sensors Snf3 and Rgt2 in Saccharomyces cerevisiae
    M J Lafuente
    Instituto de Investigaciones Biom edicas Alberto Sols, CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Mol Microbiol 35:161-72. 2000
    ..A double mutant, snf3 rgt2, recovered sensitivity to glucose when MTH1 was deleted, thus showing that glucose signalling may occur independently of Snf3 and Rgt2. A model for the possible mode of action of Snf3 and Rgt2 is presented...
  60. ncbi Cloning and functional characterization of the mouse fructose transporter, GLUT5
    Christopher P Corpe
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1576:191-7. 2002
    ....
  61. ncbi Structure-function analysis of the glucose-6-phosphate transporter deficient in glycogen storage disease type Ib
    Li Yuan Chen
    Section on Cellular Differentiation, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Hum Mol Genet 11:3199-207. 2002
    ..Finally, we show that degradation of both wild-type and mutant G6PT is inhibited by a potent proteasome inhibitor, lactacystin, demonstrating that G6PT is a substrate for proteasome-mediated degradation...
  62. ncbi The putative glucose 6-phosphate translocase gene is mutated in essentially all cases of glycogen storage disease type I non-a
    M Veiga-da-Cunha
    Laboratory of Physiological Chemistry, Brussels, Belgium
    Eur J Hum Genet 7:717-23. 1999
    ..Isolated defects in microsomal Pi transporter or in microsomal glucose transporter must be very rare or have phenotypes that are not recognised as GSD I, so that in practice there are only two subtypes of GSD I (GSD Ia and GSD Ib)...
  63. pmc Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality
    Ksenija Slavic
    Centre for Infection, Cellular and Molecular Medicine, St George s University of London, London, UK
    Mol Microbiol 75:1402-13. 2010
    ....
  64. pmc Involvement of abscisic acid in the coordinated regulation of a stress-inducible hexose transporter (VvHT5) and a cell wall invertase in grapevine in response to biotrophic fungal infection
    Matthew A Hayes
    Commonwealth Scientific and Industrial Research Organization Plant Industry, Glen Osmond, South Australia 5064, Australia
    Plant Physiol 153:211-21. 2010
    ..Our data suggest a central role for ABA in the regulation of VvcwINV and VvHT5 expression during the transition from source to sink in response to infection by biotrophic pathogens...
  65. pmc Aspergillus niger mstA encodes a high-affinity sugar/H+ symporter which is regulated in response to extracellular pH
    Patricia A vanKuyk
    Molecular Genetics of Industrial Microorganisms Wageningen University, Dreijenlaan 2, 6703 HA Wageningen, The Netherlands
    Biochem J 379:375-83. 2004
    ..1-60 mM D-glucose, D-mannose, D-fructose or D-xylose. This indicates that A. niger possesses other transporters capable of compensating for the absence of MSTA...
  66. ncbi Insulin-regulated trafficking of dual-labeled glucose transporter 4 in primary rat adipose cells
    K Dawson
    Experimental Diabetes, Metabolism, and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, Maryland 20892-0842, USA
    Biochem Biophys Res Commun 287:445-54. 2001
    ..Thus, HA-GLUT4-GFP will be useful to study GLUT4 trafficking in vivo while GFP on the N-terminus interferes with intracellular retention...
  67. ncbi The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter
    K Luhn
    Institut fur Zellbiologie, ZMBE, Universitat Munster, Munster, and Max Planck Institut für Klinische and Physiologische Forschung, Bad Nauheim, Germany
    Nat Genet 28:69-72. 2001
    ..Thus, we have identified the first putative GDP-fucose transporter, which has been highly conserved throughout evolution. A point mutation in its gene is responsible for the disease in this patient with LAD II...
  68. ncbi Molecular and functional characterization of a fructose specific transporter from the gray mold fungus Botrytis cinerea
    Gunther Doehlemann
    University of Kaiserslautern, Department of Biology, P O Box 3049, 67653 Kaiserslautern, Germany
    Fungal Genet Biol 42:601-10. 2005
    ..Thus, we propose that the specific effect of fructose on germination is not due to transport but rather to an as yet unknown intracellular sensing...
  69. pmc Hexose transporters of a hemibiotrophic plant pathogen: functional variations and regulatory differences at different stages of infection
    Ulrike Lingner
    Friedrich Alexander University Erlangen Nuremberg, Staudtstrasse 5, D 91058 Erlangen, Germany
    J Biol Chem 286:20913-22. 2011
    ..Phylogenetic studies revealed hexose transporters closely related to the five CgHXT proteins also in other pathogenic fungi suggesting conserved functions of these proteins during fungal pathogenesis...
  70. ncbi The CD28 signaling pathway regulates glucose metabolism
    Kenneth A Frauwirth
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 16:769-77. 2002
    ..These data suggest that CD28 costimulation functions to increase glycolytic flux, allowing T cells to anticipate energetic and biosynthetic needs associated with a sustained response...
  71. ncbi Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency
    T Lubke
    Georg August Universitat Gottingen, Abteilung Biochemie II, Heinrich Düker Weg 12, Gottingen, Germany
    Nat Genet 28:73-6. 2001
    ..Following the recent recommendations for the nomenclature for CDG, this new type is classified as CDG-IIc (formerly LAD II)...
  72. pmc An expression-driven approach to the prediction of carbohydrate transport and utilization regulons in the hyperthermophilic bacterium Thermotoga maritima
    Shannon B Conners
    Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695 7905, USA
    J Bacteriol 187:7267-82. 2005
    ..maritima, the present study illustrates how expression-based strategies can be used for improving genome annotation in other microorganisms, especially those for which genetic systems are unavailable...
  73. ncbi Identification of the mstE gene encoding a glucose-inducible, low affinity glucose transporter in Aspergillus nidulans
    Josep V Forment
    Instituto de Agroquimica y Tecnologia de Alimentos, Consejo Superior de Investigaciones Cientificas, Apartado de Correos 73, Burjassot, 46100 Valencia, Spain
    J Biol Chem 281:8339-46. 2006
    ..Deletion of mstE has no morphological phenotype but results in the absence of low affinity glucose uptake kinetics, the latter being substituted by a high affinity system...
  74. pmc SUT2, a putative sucrose sensor in sieve elements
    L Barker
    Plant Physiology, Zentrum für Molekularbiologie der Pflanzen ZMBP, Universitat Tubingen, Germany
    Plant Cell 12:1153-64. 2000
    ....
  75. ncbi Sensors of extracellular nutrients in Saccharomyces cerevisiae
    H Forsberg
    Ludwig Institute for Cancer Research, Stockholm, Sweden
    Curr Genet 40:91-109. 2001
    ..The fact that yeast plasma membrane nutrient sensors have only recently been discovered reveals how little is understood regarding the molecular signals that enable eukaryotic cells to adapt to changing environments...
  76. pmc Identification, purification, and molecular cloning of a putative plastidic glucose translocator
    A Weber
    Universitat zu Koln, Lehrstuhl Botanik II, Gyrhofstrasse 15, D 50931 Cologne, Germany
    Plant Cell 12:787-802. 2000
    ..This transporter, initially characterized more than 20 years ago, is closely related to the mammalian glucose transporter GLUT family and differs from all other plant hexose transporters that have been characterized to date...
  77. pmc Asymmetric signal transduction through paralogs that comprise a genetic switch for sugar sensing in Saccharomyces cerevisiae
    Jeffrey Sabina
    Department of Genetics, Washington University in Saint Louis, St Louis, Missouri 63108, USA
    J Biol Chem 284:29635-43. 2009
    ....
  78. ncbi Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways
    Lidia Tomas-Cobos
    Instituto de Biomedicina de Valencia, Jaime Roig 11, 46010 Valencia, Spain
    J Biol Chem 279:22010-9. 2004
    ..Coordinated regulation of the two signaling pathways is required for expression of HXT1 by glucose and in response to osmostress...
  79. pmc Validation of the hexose transporter of Plasmodium falciparum as a novel drug target
    Thierry Joet
    Department of Cellular and Molecular Medicine, Infectious Diseases, St George s Hospital Medical School, Cranmer Terrace, London SW17 ORE, United Kingdom
    Proc Natl Acad Sci U S A 100:7476-9. 2003
    ..Our robust expression system conclusively validates PfHT as a novel drug target and is an important step in the development of novel antimalarials directed against membrane transport proteins...
  80. ncbi The regulatory roles of the galactose permease and kinase in the induction response of the GAL network in Saccharomyces cerevisiae
    Kristy M Hawkins
    Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    J Biol Chem 281:13485-92. 2006
    ..This result indicates that Gal1p may play a previously undescribed role in the stability of the GAL network response...
  81. ncbi Functional characterization of the alpha-glucoside transporter Sut1p from Schizosaccharomyces pombe, the first fungal homologue of plant sucrose transporters
    A Reinders
    Plant Physiology, Zentrum für Molekularbiologie der Pflanzen ZMBP, Universitat Tubingen, Auf der Morgenstelle 1, D 72076 Tubingen, Germany
    Mol Microbiol 39:445-54. 2001
    ..These results indicate that, unlike S. cerevisiae, S. pombe utilizes maltose transporters derived from a common ancestor with the plant SUTs...
  82. pmc Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake
    Aimee L Edinger
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Biol Cell 13:2276-88. 2002
    ..These results suggest that growth factors control cellular growth and survival by regulating cellular access to extracellular nutrients in part by modulating the activity of Akt and mTOR...
  83. ncbi Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells
    B Thorens
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 55:281-90. 1988
    ..Insulinoma cells express, inappropriately, the erythrocyte glucose transporter, and we suggest that this may be related to their inability to secrete insulin in response to elevations in glucose...
  84. pmc Amplification of an alternate transporter gene suppresses the avirulent phenotype of glucose transporter null mutants in Leishmania mexicana
    Xiuhong Feng
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    Mol Microbiol 71:369-81. 2009
    ..These results underscore the importance of hexose transporters for the infectious stage of the parasite life cycle...
  85. ncbi Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib
    I Gerin
    Laboratory of Physiological Chemistry, Institute of Cellular Pathology and University of Louvain, Brussels, Belgium
    FEBS Lett 419:235-8. 1997
    ..The encoded protein is therefore most likely the glucose 6-phosphate translocase that is functionally associated with glucose-6-phosphatase...
  86. ncbi Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator
    N Miura
    Department of Physiological Chemistry, Tokyo Metropolitan Institute of Medical Science Rinshoken
    J Biochem 120:236-41. 1996
    ..To our knowledge, this is the first mammalian nucleotide-sugar translocator whose cDNA sequence has been described...
  87. ncbi Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking
    Jonathan S Bogan
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 425:727-33. 2003
    ..Our data suggest that TUG traps endocytosed GLUT4 and tethers it intracellularly, and that insulin mobilizes this pool of retained GLUT4 by releasing this tether...
  88. ncbi A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
    Hakon Hakonarson
    Center for Applied Genomics, Abramson Research Center, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Nature 448:591-4. 2007
    ..These results indicate that KIAA0350 might be involved in the pathogenesis of T1D and demonstrate the utility of the genome-wide association approach in the identification of previously unsuspected genetic determinants of complex traits...
  89. ncbi VvHT1 encodes a monosaccharide transporter expressed in the conducting complex of the grape berry phloem
    Céline Vignault
    Unité Mixte de Recherches Centre National de la Recherche Scientifique 6161, Transport des Assimilats, Laboratoire de Physiologie, Biochimie et Biologie Moléculaire Végétales, Bâtiment Botanique, Universite de Poitiers, Poitiers, France
    J Exp Bot 56:1409-18. 2005
    ..The expression and functional properties of VvHT1 suggests that it retrieves the monosaccharides needed to provide the energy necessary for cell division and cell growth at an early stage of berry development...
  90. pmc Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes
    Pablo Strobel
    Molecular Nutrition Laboratory, Faculty of Biological Sciences, Universidad Catolica de Chile, Casilla 114 D, Santiago, Chile
    Biochem J 386:471-8. 2005
    ..Furthermore, the results suggest that GLUT transporters are involved in flavonoid incorporation into cells...
  91. ncbi Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: potential new anticancer target for curcumin
    Anissa Belkaid
    Laboratoire d Oncologie Moleculaire, Departement de Chimie, Centre BIOMED, Universite du Quebec a Montreal, C P 8888, Succ Centre Ville, Montreal, Que, Canada H3C 3P8
    FEBS Lett 580:3746-52. 2006
    ..Targeting G6PT expression may provide a new mechanistic rationale for the action of chemopreventive drugs and lead to the development of new anti-cancer strategies...
  92. pmc Site-directed alkylation of cysteine to test solvent accessibility of membrane proteins
    Lan Guan
    Department of Physiology, University of California Los Angeles, Los Angeles, California, USA
    Nat Protoc 2:2012-7. 2007
    ..Gels are dried and exposed to a PhosphoImager screen for 1-5 d, and incorporation of radioactivity is visualized. Initial results can be obtained in 24 h...
  93. ncbi TOR kinase pathway and 14-3-3 proteins regulate glucose-induced expression of HXT1, a yeast low-affinity glucose transporter
    Lidia Tomas-Cobos
    Instituto de Biomedicina de Valencia CSIC, Jaime Roig 11, 46010 Valencia, Spain
    Yeast 22:471-9. 2005
    ..Inhibition of the TOR kinase pathway by rapamycin treatment abolishes HXT1 glucose induction. A possible involvement of PP2A protein phosphatase complex, through the Cdc55 B-subunit, in the glucose induction of HXT1 is also discussed...
  94. ncbi Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity
    M Muraoka
    Department of Physiological Chemistry, The Tokyo Metropolitan Institute of Medical Science Rinshoken, 18 22 Honkomagome 3 chome, Bunkyo ku, 113 8613, Tokyo, Japan
    FEBS Lett 495:87-93. 2001
    ..The possibility that this transporter participates in glucuronidation and/or chondroitin sulfate biosynthesis is discussed...
  95. pmc Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle
    Ksenija Slavic
    Centre for Infection and Immunity, Division of Clinical Sciences, St George s, University of London, London SW170RE, United Kingdom
    Antimicrob Agents Chemother 55:2824-30. 2011
    ..These data indicate that novel chemotherapeutic interventions that target PfHT may be active against liver and, to a lesser extent, transmission stages, in addition to blood stages...
  96. ncbi Sugar transporters from bacteria, parasites and mammals: structure-activity relationships
    A R Walmsley
    Division of Infection and Immunity, University of Glasgow, UK
    Trends Biochem Sci 23:476-81. 1998
    ..Subtle distinctions in the function of these proteins can be related to particular amino acid residue substitutions...
  97. pmc Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
    Jeffrey C Rathmell
    Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 23:7315-28. 2003
    ..The prevention of Bax activation by posttranscriptional regulation of glucose metabolism may, therefore, be a required aspect of the ability of Akt to maintain long-term cell survival in the absence of growth factors...
  98. pmc Glucose uptake and catabolite repression in dominant HTR1 mutants of Saccharomyces cerevisiae
    S Ozcan
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    J Bacteriol 175:5520-8. 1993
    ..Alternatively, some unidentified regulatory components of the glucose transport system may be involved in the generation or transmission of signals for glucose repression...
  99. ncbi Molecular basis for glucose-galactose malabsorption
    Ernest M Wright
    Department of Physiology, UCLA School of Medicine, Los Angeles, CA 90095 1751, USA
    Cell Biochem Biophys 36:115-21. 2002
    ..We conclude that mutations in the SGLT1 gene are the cause of glucose-galactose malabsorption, and sugar transport is impaired mainly because the mutant proteins are either truncated or are not targeted properly to the cell membrane...
  100. ncbi The hexose transporters of Saccharomyces cerevisiae play different roles during enological fermentation
    Kattie Luyten
    UMR Sciences Pour 1 CEnologie, INRA ENSAM UMI, 2 place Viala, F 34060 Montpellier, France
    Yeast 19:713-26. 2002
    ..This work shows that the successful alcoholic fermentation of wine involves at least four or five hexose carriers, playing different roles at various stages in the fermentation cycle...
  101. pmc Hxt-carrier-mediated glucose efflux upon exposure of Saccharomyces cerevisiae to excess maltose
    Mickel L A Jansen
    Kluyver Laboratory of Biotechnology, Delft University of Technology, 2628 BC Delft, The Netherlands
    Appl Environ Microbiol 68:4259-65. 2002
    ..This is a relevant phenomenon for selection of maltose-constitutive strains for baking and brewing...

Research Grants77

  1. Membrane Proteins of S. mansoni as Vaccine Candidates
    Donald Harn; Fiscal Year: 2002
    ..Data provided by these experiments will provide information about the mechanism of parasite killing and suggest whch formulations of SGTP4 will boost protective immunity...
  2. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  3. Biology of IGFs in Bone
    Thomas L Clemens; Fiscal Year: 2013
    ..An understanding of this pathway should ultimately enable better management of diabetic veterans and conceivably lead to the design a single therapy, which can simultaneously target both osteoporosis and type 2 diabetes. ..
  4. Targeting GRK2 (BARK1) in Heart Failure
    Walter J Koch; Fiscal Year: 2013
    ..abstract_text> ..
  5. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
    ..This research will help us better understand how such environmental exposures may affect the male reproductive tract. ..
  6. The Role of Substrate Metabolism and Macrophage Activation in Obesity
    Amy Johnson; Fiscal Year: 2013
    ....
  7. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ....
  8. CELLULAR REGULATION OF CLATHRIN ASSEMBLY AND FUNCTION
    Frances M Brodsky; Fiscal Year: 2013
    ....
  9. Effect of exposure to organochlorine compounds on the development of obesity and
    GEORGE E HOWELL; Fiscal Year: 2011
    ..This research will determine if exposure to these compounds is a risk factor for development of T2D and if so will provide mechanisms through which these compounds precipitate this disease. ..
  10. Development of a mouse model of obesity in pregnancy
    Thomas Jansson; Fiscal Year: 2009
    ....
  11. Paternal Environmental Exposures and Reproductive Outcomes: A Comparison of in Vi
    DEBORAH ANN HANSEN; Fiscal Year: 2013
    ..In vivo and in vitro parameters include: a) 14.5 dpc placental and fetal weights, and crown to rump lengths;b) full term litter size, birth weights, and 5 week growth rates;and c) gross and microscopic structure. ..
  12. Phosphoprotein CDP138 regulates glucose metabolism
    ZHEN YUE JIANG; Fiscal Year: 2013
    ..Together, this project will provide valuable and novel insight into the molecular mechanisms by which CDP138 acts as a point of convergence between kinase activation and glucose transport. ..
  13. Biochemistry and Cell Biology of CHC22 Clathrin
    Frances M Brodsky; Fiscal Year: 2013
    ..The proposed research will characterize the molecular mechanism of CHC22 function, its cellular regulation and its relationship to membrane traffic pathways that malfunction in diabetes. ..
  14. Role of Rab GAPs AS160 and Tbc1d1 in GLUT4 translocation and glucose homeostasis
    Susanna R Keller; Fiscal Year: 2013
    ....
  15. Adiponectin regulates nutrient transport in the placenta
    Theresa L Powell; Fiscal Year: 2009
    ..This research may lead to the development of intervention strategies to reduce birth weight in pregnancies of obese women, which will reduce the susceptibility to obesity in the next generation. ..
  16. Mechanisms of Membrane-Based Insulin Resistance &Therapeutic Reversal Strategies
    Jeffrey S Elmendorf; Fiscal Year: 2012
    ..We have also identified means to protect against this derangement, and further investigation of the mechanisms involved will hopefully lead to new therapeutic strategies to curtail the accelerated expansion of the T2D population. ..
  17. The Role of Myosin in Vesicle Trafficking
    Yashomati M Patel; Fiscal Year: 2010
    ..The proposed research will provide critical information for understanding the molecular mechanism(s) involved in the development of in type 2 diabetes. ..
  18. Steroid regulation of glucose utilization during early pregnancy.
    ANTONINA I FROLOVA; Fiscal Year: 2010
    ....
  19. Mechanisms of glucosensation mediating food choice behavior in Drosophila
    Monica Dus; Fiscal Year: 2013
    ..They will also provide mammalian researchers with conserved genes to use as molecular and neurochemical markers in future studies of glucosensation, feeding, and disease. ..
  20. Pioglitazone & Exercise Effects on Older Aldults with MCI and Metabolic Syndrome
    Robert S Schwartz; Fiscal Year: 2010
    ..This study will assess novel metabolic treatments for patients with both MCI and MS, with the aim of delaying the progression of these patients to dementia. ..
  21. The role of exposure to bioaccumulative organochlorine compounds on the occurrenc
    GEORGE E HOWELL; Fiscal Year: 2010
    ..If so, the present study will provide mechanisms through which these compounds promote this disease and will establish exposure to certain organochlorine compounds as a risk factor for the development of type 2 diabetes. ..
  22. Sweet taste receptors and glucose metabolism in healthy and T2DM humans
    Karen L Teff; Fiscal Year: 2012
    ..Our overall hypothesis is that in healthy subjects, the STR receptor is involved in the regulation of post-prandial glucose metabolism and GLP levels but in T2DM, the STR receptor is unresponsive to activation or inhibition ..
  23. Engineering an in vitro model of adipose tissue formation and metabolism
    Kyongbum Lee; Fiscal Year: 2010
    ..Prospectively, these insights could lead to novel metabolic targets or nutritional strategies to control diseases and disorders resulting from or related to excessive AT expansion, including obesity and type 2 diabetes. ..
  24. GLUT8 Overexpression in Cardioprotection
    Maureen J Charron; Fiscal Year: 2010
    ..Preliminary studies in this proposal show that hearts overexpressing the GLUT8 glucose transporter are resistant to ischemic injury. The therapeutic potential of GLUT8 overexpression in diabetic models will be assessed in this proposal. ..
  25. Candida albicans Epithelial Cell Interactions and Oropharyngeal Disease
    Scott G Filler; Fiscal Year: 2013
    ..albicans Cht2 and Hgt12 govern epithelial cell invasion, damage, and virulence;and 3) use overexpression-rescue and null mutant analysis to identify additional target genes of Tpk2 that mediate epithelial cell invasion and damage. ..
  26. Insulin Action on GLUT4 and FOXO1 in the Brain
    Garrett Heinrich; Fiscal Year: 2012
    ..This project studies the function of neurons in the brain that express the glucose transporter GLUT4 and gene transcription factor FOXO1 and how insulin action in those neurons maintains peripheral glucose homeostasis. ..
  27. Refined Fructose Promotes Pancreatic Cancer Growth
    Anthony P Heaney; Fiscal Year: 2011
    ..Our identification of GLUT-5 as a key in the molecular mechanism by which pancreatic cancer cells preferentially utilize fructose may pave the way to novel therapeutic approaches targeting GLUT-5 action in pancreatic cancer. ..
  28. GLUTS AND GLUCOSE TRANSPORT IN THE MOUSE BLASTOCYST
    Kelle H Moley; Fiscal Year: 2012
    ..By modulating the rate of autophagy during the preimplantation period in these models and then transferring these embryos into surrogate mice, the outcomes of these manipulations are determined. ..
  29. Mechanisms of glucose mediated cardiac mitochondrial dysfunction
    ADAM RAYMOND WENDE; Fiscal Year: 2013
    ..Collectively, the completion of these studies will provide fundamental insights into the mechanistic basis for glucose in the development of diabetic cardiomyopathy and mitochondrial dysfunction. ..
  30. Mechanisms of glucose mediated cardiac mitochondrial dysfunction
    ADAM RAYMOND WENDE; Fiscal Year: 2013
    ..Collectively, the completion of these studies will provide fundamental insights into the mechanistic basis for glucose in the development of diabetic cardiomyopathy and mitochondrial dysfunction. ..
  31. Cytoskeletal Regulation of Erythrocyte Glucose Transporter-1
    Athar H Chishti; Fiscal Year: 2012
    ..abstract_text> ..
  32. Genetics of Obesity in Yup'ik Eskimos
    BERT BRANDON BOYER; Fiscal Year: 2011
    ..abstract_text> ..
  33. Connecting metabolic stress and cell physiology in Escherichia coli
    GREGORY ROSS RICHARDS; Fiscal Year: 2012
    ....
  34. GLUCOSE TRANSPORTER REGULATION IN OBESITY AND DIABETES
    Barbara B Kahn; Fiscal Year: 2013
    ..These studies will elucidate novel mechanisms underlying the inter-tissue communication that plays an important role in the pathogenesis of type 2 diabetes. ..
  35. Functional mapping of SNARE-dependent trafficking and fusion
    Jeffrey E Pessin; Fiscal Year: 2013
    ..Thus, understanding the mechanism for this translocation process and the ability of insulin to increase glucose uptake are essentially process for the maintenance of normal glucose homeostasis. 1 ..
  36. PGC-1alpha and GABAergic Dysfunction in Huntington Disease
    Rita Marie Cowell; Fiscal Year: 2013
    ..These studies will test whether transcriptional pathways that control mitochondrial function and calcium homeostasis in interneurons have potential as targets for treatment of patients with HD. ..
  37. Role of SGLT3 in diabetes-mediated increased renal sodium reabsorption
    Niloofar M Tabatabai; Fiscal Year: 2013
    ..The proposed in vitro and in vivo studies are designed to investigate the role of SGLT3 as a novel glucose-stimulated Na+ transporter that may play role in the enhanced Na+ reabsorption in diabetes. ..
  38. CHC22 CLATHRIN FUNCTION IN HUMAN GLUCOSE METABOLISM
    FRANCES BRODSKY; Fiscal Year: 2009
    ..The research proposed here will establish novel characteristics of human glucose homeostasis and will enable development of better animal models for studying its dysfunction in diabetes. ..
  39. Functional Characterization of Leishmania Transporters
    Scott M Landfear; Fiscal Year: 2010
    ..Overall, this proposal will provide a detailed biochemical and genetic dissection of glucose transporter function and the essential role of these permeases in the parasite life cycle. ..
  40. Adipose Tissue Branched-Chain Amino Acid Metabolism and Glucose Homeostasis
    Mark A Herman; Fiscal Year: 2010
    ..The ultimate goal is for the applicant to become an independent investigator. ..
  41. Molecular motors in cell biology
    Yale E Goldman; Fiscal Year: 2013
    ..We anticipate that the proposed work will take us significantly further toward our goal of understanding motility in the normal and pathological function of cells. ..
  42. Gene and environment interaction and insulin resistance
    Raquel Villegas; Fiscal Year: 2013
    ..Findings from this study can be used to aid in the prevention of T2D, since insulin resistance is a reversible condition. ..
  43. Development of Assay for High Throughput Screen of Parasite Glucose Transporter
    Scott M Landfear; Fiscal Year: 2010
    ..Since glucose is an essential nutrient for these parasites, such compounds would kill the parasite and could act as novel drugs for treatment of the diseases they cause. ..
  44. Evaluation of BRAF-inhibitor induced alterations in glucose metabolism
    Nicholas Theodosakis; Fiscal Year: 2013
    ..New discoveries in the mechanisms underpinning metabolic changes may also suggest new metabolically-based combination therapies aimed at overcoming vemurafenib resistance. ..
  45. INSULIN REGULATED MEMBRANE TRAFFICKING
    Timothy E McGraw; Fiscal Year: 2013
    ..The results of this ambitious and comprehensive study will significantly advance our understanding of the molecular mechanisms controlling the trafficking of Glut4 between the plasma membrane and endomembrane compartments of adipocytes. ..
  46. How glucose transporter structure affects its function
    Anthony Carruthers; Fiscal Year: 2013
    ..abstract_text> ..
  47. Selective Inhibitors of the Hexose Transporter from African Trypansomes
    Scott Landfear; Fiscal Year: 2013
    ..Kip Guy, who operates an internationally renowned compound screening and pharmaceutical chemistry facility at St. Jude and who has a strong track record of screening for anti-parasitic compounds. ..
  48. Is GLUT1 required for tumor growth and the Warburg Effect?
    Steven M Anderson; Fiscal Year: 2013
    ....
  49. Flagellar targeting and sensory function of a glucose transporter in L. mexicana.
    KHOA DANG TRAN; Fiscal Year: 2013
    ..These studies aim to elucidate a flagellar targeting pathway that likely operates for multiple membrane proteins in Leishmania and related trypanosomes, as well as identify a flagellar specific sensory role for this glucose transporter. ..
  50. SUBCELLULAR LOCALIZATION OF PI 3-KINASE SIGNALING
    Michael P Czech; Fiscal Year: 2011
    ..With Project 3, we will also define the membrane topographies and structures of molecular complexes that act on GLUT4-containing vesicles in the TIRF zone, and elucidate the mechanisms involved in their actions. ..
  51. Investigating the Mechanism by which Glut4 Storage Vesicle (GSV) Fusion is Regula
    MATTHEW MOLSKI; Fiscal Year: 2013
    ..GSV fusion, the active SNAREs are syntaxin 4, SNAP-23, and VAMP2. Additional proteins are known to regulate fusion by directly interacting with the SNAREs, including Munc18c and Doc2b, but ..
  52. Targeting and Function of Golgi Membrane Proteins
    Carolyn E Machamer; Fiscal Year: 2011
    ..The proposed experiments on golgin-160 will add to our understanding of cargo delivery to the cell surface and to the role of the Golgi complex in transducing stress signals to the rest of the cell. ..
  53. Role of TUG in the Formation of Insulin-Responsive GLUT4 Vesicles
    Charisse Orme; Fiscal Year: 2011
    ..It is anticipated that the results of this work will have importance for understanding how GLUT4 glucose transporters are properly sorted from internal membranes into the insulin responsive compartment. ..
  54. Defining the Role of Boi1/Boi2 in the Coordination of Actin Polarity and Polarize
    LEAH JOY WATSON; Fiscal Year: 2013
    ..Understanding the basic mechanism involved in cell polarity thus can improve diagnostic and preventative approaches to human disease. ..
  55. Glucose Transport in Regulation of T Cell Activation and Inflammation
    Jeffrey C Rathmell; Fiscal Year: 2012
    ....
  56. Noninvasive neonatal glucose monitor
    ROSE MARIE VISCARDI; Fiscal Year: 2012
    ..The POC device will be tested only on standard glucose solutions and the porcine skin model. Phase II will involve testing of the POC device in the neonatal intensive care unit (NICU). ..
  57. Epilepsy in Primary Cerebral Energy Failure
    LEVI BOGACZ GOOD; Fiscal Year: 2010
    ..The principal aim of this project is to understand and to measure the dependence of brain excitability on brain energy metabolism by studying both normal and disease states. ..
  58. Modulation of neural function in energy failure
    JUAN MANUEL PASCUAL; Fiscal Year: 2013
    ..In summary, we expect that this proposal will help define G1D as a synaptic disorder and render it amenable to excitable or metabolic target modification. ..
  59. Regulatory Mechanisms of GLUT4 Exocytosis
    Jingshi Shen; Fiscal Year: 2013
    ..The findings will also shed light upon the diseases associated with glucose imbalances such as insulin resistance and type 2 diabetes, and will facilitate the development of novel strategies for therapeutic intervention. ..
  60. TUG-mediated GLUT4 glucose transporter trafficking and regulation by post-transla
    JONATHAN PHILIP BELMAN; Fiscal Year: 2012
    ..These are important questions for type 2 diabetes, and may also have more fundamental significance for cell biology and physiology. ..
  61. Regulatory Mechanisms of GLUT4 Exocytosis
    Jingshi Shen; Fiscal Year: 2012
    ..The findings will also shed light upon the diseases associated with glucose imbalances such as insulin resistance and type 2 diabetes, and will facilitate the development of novel strategies for therapeutic intervention. ..
  62. REGULATION OF PROTEIN TRAFFICKING IN ADIPOCYTES
    Mike M Mueckler; Fiscal Year: 2013
    ..It is directly relevant to understanding the molecular mechanisms involved in the regulation of whole body glucose homeostasis and its derangement in insulin resistant states such as diabetes, obesity, and metabolic syndrome. ..
  63. High content screening assay for activators of glucose transporter GLUT4
    ZHEN YUE JIANG; Fiscal Year: 2010
    ..We propose to develop a high throughput screening assay to identify potential small molecules that activate glucose transport system and improve insulin sensitivity, which may promote new avenues for treatment of diabetes. ..
  64. Vascular smooth muscle apoptosis prevention by glucose
    Frank Brosius; Fiscal Year: 2005
    ..We will also determine the mitochondrial metabolic effects that are most critical to both hypoxia-induced apoptosis and glucose protection in VSMCs. ..
  65. PERINATAL METABOLIC STRESS AND BRAIN GLUCOSE TRANSPORT
    SUSAN VANNUCCI; Fiscal Year: 1999
    ..The results of this study should help elucidate the mechanisms by which the immature brain responds to injury and may provide opportunities for intervention in these, and other, perinatal diseases. ..
  66. REGULATION OF GLUT1 GENE EXPRESSION BY HYPOXIA
    Faramarz Ismail Beigi; Fiscal Year: 2001
    ....
  67. SURGERY OF THE PANCREAS--EFFECTS ON GLUCOSE METABOLISM
    Dana Andersen; Fiscal Year: 1999
    ....
  68. Role of Rab GAPs AS160 and Tbc1d1 in GLUT4 translocation and glucose homeostasis
    SUSANNA KELLER; Fiscal Year: 2009
    ..It will further provide crucial information towards the validation of AS160 and Tbc1d1 as drug targets to improve glucose homeostasis and prevent ensuing complications of insulin resistance. ..
  69. Glucose Meatbolism in the Human Ovary
    MAUREEN CHARRON; Fiscal Year: 2004
    ..These observations are hoped to have relevance for understanding of basic reproductive physiology and the mechanism of reproductive dysfunction in PCOS. ..
  70. PHOSPHORYLATION OF THE GLUCOSE TRANSPORTER BY INSULIN
    David Sacks; Fiscal Year: 1991
    ..These studies should add considerably to our knowledge of the molecular mechanism by which insulin stimulates glucose transport...
  71. GLUCOSE-DEPENDENT GLUT-1 EXPRESSION IN EMBRYONIC HEART
    IDA WASHINGTON; Fiscal Year: 2003
    ....
  72. PROTEIN ENGINEERED GLUCOSE SENSOR
    Govind Rao; Fiscal Year: 1999
    ..We believe that a superior reagentless glucose sensor can be made and can have a significant impact on the ability to move towards an indwelling glucose monitoring system. ..
  73. Insulin Signaling to GLUT4 and the Actin Cytoskeleton
    Michael Czech; Fiscal Year: 2007
    ..Together, these experiments will clarify the role of Myo1c and the actin cytoskeleton in GLUT4 regulation by insulin. ..
  74. BIOLOGY OF THE BLOOD BRAIN BARRIER
    William Pardridge; Fiscal Year: 1999
    ..Extensive utilization of this Core will provide a common vehicle for interaction amongst the five projects, as well as for extension of blood-brain barrier research to the biochemical and molecular biological level. ..
  75. GLUCOSE TRANSPORTER EXPRESSION IN TRANSGENIC MICE
    ANN OLSON; Fiscal Year: 1999
    ..Understanding this mechanism will provide useful insight into the mechanisms by which GLUT4 gene expression occurs in vivo. ..
  76. REGULATION OF MEMBRANE TRANSPORT BY THYROID HORMONE
    Richard Haber; Fiscal Year: 1993
    ....
  77. SLC2A9, A Candidate ER GLUT in Normal and Cancer Cells
    Jeffrey Moley; Fiscal Year: 2002
    ..Identification of SLC2A9 as the endoplasmic reticulum glucose transporter will improve understanding of GSDs, and of glucose metabolism in benign and malignant tissues. ..