Genomes and Genes
l type calcium channels
Summary: Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
Publications301 found, 100 shown here
- Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPasesBrian S Finlin
Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
Proc Natl Acad Sci U S A 100:14469-74. 2003..Thus, the RGK GTPase family may provide a mechanism for achieving cross talk between Ras-related GTPases and electrical signaling pathways...
- Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autismIgor Splawski
Department of Cardiology, Children s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
Cell 119:19-31. 2004..These discoveries establish the importance of Ca(V)1.2 in human physiology and development and implicate Ca(2+) signaling in autism...
- 'Rejuvenation' protects neurons in mouse models of Parkinson's diseaseC Savio Chan
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Nature 447:1081-6. 2007..Such blocking ('rejuvenation') protects these neurons in both in vitro and in vivo models of Parkinson's disease, pointing to a new strategy that could slow or stop the progression of the disease...
- Preassociation of calmodulin with voltage-gated Ca(2+) channels revealed by FRET in single living cellsM G Erickson
Department of Biomedical Engineering, Calcium Signals Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Neuron 31:973-85. 2001..These results now definitively demonstrate channel-CaM preassociation in resting cells and underscore the potential of three-cube FRET for probing protein-protein interactions...
- Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathwayR E Dolmetsch
Division of Neuroscience, Children's Hospital and Department of Neurobiology, Harvard Medical School, Enders Pediatric Research Laboratories, Room 260, 300 Longwood Avenue, Boston, MA 02115, USA
Science 294:333-9. 2001..CaM functions as a local Ca2+ sensor at the mouth of the LTC that activates the MAPK pathway and leads to the stimulation of genes that are essential for neuronal survival and plasticity...
- The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factorNatalia Gomez-Ospina
Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, USA
Cell 127:591-606. 2006..These findings provide evidence that voltage-gated calcium channels can directly activate transcription and suggest a mechanism linking voltage-gated channels to the function and differentiation of excitable cells...
- Neuronal Ca(V)1.3alpha(1) L-type channels activate at relatively hyperpolarized membrane potentials and are incompletely inhibited by dihydropyridinesW Xu
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA
J Neurosci 21:5944-51. 2001..Our results suggest that functional and pharmacological criteria used commonly to distinguish among different Ca currents greatly underestimate the biological importance of L-type channels in cells expressing Ca(v)1.3alpha(1)...
- Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channelsG S Pitt
Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, California 94305, USA
J Biol Chem 276:30794-802. 2001..When the C-terminal lobe of CaM binds to the nearby CaM effector sequence (IQ motif), the braking effect is relieved, and CDI is accelerated...
- Unified mechanisms of Ca2+ regulation across the Ca2+ channel familyHaoya Liang
Ca2 Signals Laboratory, Departments of Biomedical Engineering and Neuroscience, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Neuron 39:951-60. 2003....
- Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channelsJ Platzer
Institut fur Biochemische Pharmakologie, Innsbruck, Austria
Cell 102:89-97. 2000..We conclude that alpha1D can form LTCCs with negative activation thresholds essential for normal auditory function and control of cardiac pacemaker activity...
- A CACNA1F mutation identified in an X-linked retinal disorder shifts the voltage dependence of Cav1.4 channel activationAriana Hemara-Wahanui
Biochemistry Department, University of Otago, P O Box 56, Dunedin, Aotearoa New Zealand
Proc Natl Acad Sci U S A 102:7553-8. 2005..Collectively, these findings suggest that a gain-of-function mechanism involving increased Ca(v)1.4 channel activity is likely to cause the unusual phenotype...
- An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindnessT M Strom
Abteilung Medizinische Genetik der Ludwig Maximilians Universität, Munchen, Germany
Nat Genet 19:260-3. 1998..These data indicate that aberrations in a voltage-gated calcium channel, presumably causing a decrease in neurotransmitter release from photoreceptor presynaptic terminals, are a frequent cause of CSNB2...
- CaV1.3 channels are essential for development and presynaptic activity of cochlear inner hair cellsAndreas Brandt
Department of Otolaryngology, Goettingen University Medical School, 37075 Goettingen, Germany
J Neurosci 23:10832-40. 2003..We conclude that CaV1.3 channels are essential for normal hair cell development and synaptic transmission...
- Loss-of-function mutations in a calcium-channel alpha1-subunit gene in Xp11.23 cause incomplete X-linked congenital stationary night blindnessN T Bech-Hansen
Department of Medical Genetics, University of Calgary, Alberta, Canada
Nat Genet 19:264-7. 1998..These findings establish that loss-of-function mutations in CACNA1F cause incomplete CSNB, making this disorder an example of a human channelopathy of the retina...
- Ionic mechanisms of electrical remodeling in human atrial fibrillationR F Bosch
Department of Cardiology, University of Tubingen, Germany
Cardiovasc Res 44:121-31. 1999..The cellular changes in repolarization and the underlying ionic mechanisms in human AF are only poorly understood...
- Functional properties of Cav1.3 (alpha1D) L-type Ca2+ channel splice variants expressed by rat brain and neuroendocrine GH3 cellsP Safa
Department of Pharmacology, The George Washington University, Washington, DC 20037, USA
J Biol Chem 276:38727-37. 2001..Furthermore, the QXXER motif, located on the C terminus of alpha(1D-S) subunit, is not sufficient to confer sensitivity to inhibitory G proteins...
- Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localizationJason D Foell
Department of Medicine, University of Wisconsin, Madison 53792, USA
Physiol Genomics 17:183-200. 2004..These results demonstrate a previously unappreciated heterogeneity of Ca(v)beta subunit isoforms in ventricular myocytes and suggest the presence of different subcellular populations of Ca2+ channels with distinct functional properties...
- Analysis of the complex between Ca2+ channel beta-subunit and the Rem GTPaseBrian S Finlin
Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
J Biol Chem 281:23557-66. 2006....
- Structure of calmodulin bound to the hydrophobic IQ domain of the cardiac Ca(v)1.2 calcium channelJennifer L Fallon
Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Structure 13:1881-6. 2005..These findings suggest that this structure could represent the conformation that calmodulin assumes in CDF...
- Autoinhibitory control of the CaV1.2 channel by its proteolytically processed distal C-terminal domainJoanne T Hulme
Department of Pharmacology, Mailstop 357280, University of Washington, Seattle, 98195 7280, USA
J Physiol 576:87-102. 2006..2 channel function...
- Phosphorylation of serine 1928 in the distal C-terminal domain of cardiac CaV1.2 channels during beta1-adrenergic regulationJoanne T Hulme
Department of Pharmacology, University of Washington, Mailstop 357280, Seattle, WA 98195 7280, USA
Proc Natl Acad Sci U S A 103:16574-9. 2006..Our results correlate phosphorylation of S1928 with beta1-adrenergic functional up-regulation of cardiac calcium channels in the presence of BAPTA in intact ventricular myocytes...
- Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activityMatteo E Mangoni
Unité Propre de Recherche 1142, Centre National de la Recherche Scientifique, Institut de Genetique Humaine, 141 rue de la Cardonille, Montpellier Cedex 5, France
Proc Natl Acad Sci U S A 100:5543-8. 2003..Taken together, our data demonstrate that Ca(v)1.3 channels play a major role in the generation of cardiac pacemaker activity by contributing to diastolic depolarization in SAN pacemaker cells...
- Loss of Cav1.3 channels reveals the critical role of L-type and BK channel coupling in pacemaking mouse adrenal chromaffin cellsAndrea Marcantoni
Department of Neuroscience, Nanostructured Interfaces and Surfaces Centre of Excellence, Consorzio Nazionale Interuniversitario per le Scienze Fisiche della Materia, 10125 Torino, Italy
J Neurosci 30:491-504. 2010..2, as subthreshold pacemaker channels in MCCs and open new interesting features about their role in the control of firing and catecholamine secretion at rest and during sustained stimulations matching acute stress...
- Functional stoichiometry and local enrichment of calmodulin interacting with Ca2+ channelsMasayuki X Mori
Ca2 Signals Laboratory, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Science 304:432-5. 2004..This estimate indicates marked enrichment of local CaM, as if a "school" of nearby CaMs were poised to enhance the transduction of local Ca2+ entry into diverse signaling pathways...
- The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entryRoger A Bannister
Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
J Gen Physiol 133:79-91. 2009..Collectively, these results indicate that the skeletal muscle L-type channel is a major contributor to the Ca(2+) entry attributed to ECCE...
- The CACNA1F gene encodes an L-type calcium channel with unique biophysical properties and tissue distributionJohn E McRory
Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
J Neurosci 24:1707-18. 2004..Immunohistochemical analyses show that, in contrast with previous reports, Ca(v)1.4 is widely distributed outside the retina, including in the immune system, thus suggesting a broader role in human physiology...
- Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase CT J Kamp
Department of Medicine, University of Wisconsin, Madison, WI 53792 3248, USA
Circ Res 87:1095-102. 2000..Crosstalk between PKA and PKC pathways occurs in the modulation of I:(Ca). Ultimately, precise regulation of I:(Ca) is needed for normal cardiac function, and alterations in these regulatory pathways may prove important in heart disease...
- Atrial L-type Ca2+ currents and human atrial fibrillationD R Van Wagoner
Department of Cardiology and Kaufman Center for Heart Failure, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Circ Res 85:428-36. 1999..The reduction in functional I(Ca) density in myocytes from the atria of chronic AF patients may thus be an adaptive response to the arrhythmia-induced calcium overload...
- Congenital stationary night blindness type 2 mutations S229P, G369D, L1068P, and W1440X alter channel gating or functional expression of Ca(v)1.4 L-type Ca2+ channelsJean Charles Hoda
Abteilung Pharmakologie und Toxikologie, Institut fur Pharmazie, Universitat Innsbruck, A 6020 Innsbruck, Austria
J Neurosci 25:252-9. 2005..The lower activation range of G369D can explain the reduced dynamic range of photoreceptor signaling. Moreover, we demonstrate that loss of channel function of one (L1068P) CSNB2 mutation can be rescued by a Ca2+ channel activator...
- alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltagesA Koschak
Institut fur Biochemische Pharmakologie, Peter Mayr Strasse 1, A 6020 Innsbruck, Austria
J Biol Chem 276:22100-6. 2001..These properties should allow D-LTCCs to control physiological processes, such as diastolic depolarization in sinoatrial node cells, neurotransmitter release in IHCs and neuronal excitability...
- Structural and functional abnormalities of retinal ribbon synapses due to Cacna2d4 mutationKatharina A Wycisk
Division of Medical Molecular Genetics and Gene Diagnostics, Institute of Medical Genetics, University of Zurich, Schwerzenbach, Switzerland
Invest Ophthalmol Vis Sci 47:3523-30. 2006..Rod photoreceptor responses were maintained with reduced amplitude, whereas cone activities were absent. This study was conducted to identify the genetic defect underlying this hitherto unknown autosomal recessive cone-rod dysfunction...
- Tuning of synapse number, structure and function in the cochleaAlexander C Meyer
InnerEarLab, Department of Otolaryngology and Center for Molecular Physiology of the Brain, University of Gottingen, Gottingen, Germany
Nat Neurosci 12:444-53. 2009..However, we observed substantial variability for presynaptic Ca(2+) signals, even within individual IHCs, providing a candidate presynaptic mechanism for the divergent dynamics of spiral ganglion neuron spiking...
- L-type calcium channels: the low downDiane Lipscombe
Department of Neuroscience, Brown University, 190 Thayer Street, Providence, RI 02912, USA
J Neurophysiol 92:2633-41. 2004..A more accurate view of neuronal L-type calcium channels encompasses a broad range of activation thresholds and recognizes their potential contribution to signaling cascades triggered by subthreshold depolarizations...
- Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failureHiroyuki Nakayama
Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA
J Clin Invest 117:2431-44. 2007....
- Selective elimination of glutamatergic synapses on striatopallidal neurons in Parkinson disease modelsMichelle Day
Department of Physiology, 303 East Chicago Avenue, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Nat Neurosci 9:251-9. 2006..3 L-type Ca(2+) channels. The disconnection of striatopallidal neurons from motor command structures is likely to be a key step in the emergence of pathological activity that is responsible for symptoms in Parkinson disease...
- Constitutively active L-type Ca2+ channelsManuel F Navedo
Department of Physiology and Biophysics, University of Washington, Box 357290, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 102:11112-7. 2005..We propose that Ca(2+) influx via persistent LTCCs may be an important mechanism regulating steady-state local and global Ca(2+) signals...
- Regulation of L-type Ca2+ channel activity and insulin secretion by the Rem2 GTPaseBrian S Finlin
Department of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, Lexington, Kentucky 40536, USA
J Biol Chem 280:41864-71. 2005....
- A summary of 20 CACNA1F mutations identified in 36 families with incomplete X-linked congenital stationary night blindness, and characterization of splice variantsK M Boycott
Department of Medical Genetics, University of Calgary, AB, Canada
Hum Genet 108:91-7. 2001..In characterizing transcripts of CACNA1F we have identified several splice variants and defined a prototypical sequence based on the location of mutations in splice variants and comparison with the mouse orthologue, Cacnalf...
- 17Beta-estradiol induced Ca2+ influx via L-type calcium channels activates the Src/ERK/cyclic-AMP response element binding protein signal pathway and BCL-2 expression in rat hippocampal neurons: a potential initiation mechanism for estrogen-induced neuropT W Wu
Neuroscience Program, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089 9121, USA
Neuroscience 135:59-72. 2005..Implications of these data for understanding estrogen action in brain and use of estrogen therapy for prevention of neurodegenerative disease are discussed...
- A single CaVbeta can reconstitute both trafficking and macroscopic conductance of voltage-dependent calcium channelsStanislava Dalton
Calcium Signals Laboratory, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Physiol 567:757-69. 2005....
- Expression of bestrophin-1, the product of the VMD2 gene, modulates voltage-dependent Ca2+ channels in retinal pigment epithelial cellsRita Rosenthal
Augenklinik, Charite Universitaetsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
FASEB J 20:178-80. 2006....
- Severe arrhythmia disorder caused by cardiac L-type calcium channel mutationsIgor Splawski
Howard Hughes Medical Institute, Department of Cardiology, and Genomics Program and Division of Genetics, Children s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:8089-96; discussion 8086-8. 2005..These data indicate that gain-of-function mutations of CaV1.2 exons 8 and 8A cause distinct forms of TS...
- Clinical variability among patients with incomplete X-linked congenital stationary night blindness and a founder mutation in CACNA1FK M Boycott
Department of Medical Genetics, Faculty of Medicine, University of Calgary, Alta
Can J Ophthalmol 35:204-13. 2000..We assessed the clinical variability in the expression of the incomplete CSNB phenotype in a subgroup of patients of Mennonite ancestry with the same founder mutation...
- Neurophysiology: stressful pacemakingBruce P Bean
Nature 447:1059-60. 2007
- Meiosis reinitiation in Ruditapes philippinarum (Mollusca): involvement of L-calcium channels in the release of metaphase I blockM Moreau
Universite Paul Sabatier, Toulouse, France
Zygote 4:151-7. 1996..Taken together these data suggest that the absence of L-type calcium channels in the membrane of prophase-arrested oocytes of Ruditapes may account for their inability to be fertilised...
- The voltage-dependent calcium channel beta subunit contains two stable interacting domainsYarden Opatowsky
Department of Biochemistry, Faculty of Life Sciences, Tel Aviv University, Sherman Bldg, Rm 621, Ramat Aviv 69978, Israel
J Biol Chem 278:52323-32. 2003..Domain II is responsible for this binding, but domain I enhances it...
- Syntaxin 1A modulates the voltage-gated L-type calcium channel (Ca(v)1.2) in a cooperative mannerHadar Arien
Institute of Life Sciences, Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
J Biol Chem 278:29231-9. 2003..As shown herein, the supralinear relationship between Sx1A and the voltage-gated Ca2+ channel within the cluster could convey the cooperativity that distinguishes the process of neurotransmitter release...
- Computer model of action potential of mouse ventricular myocytesVladimir E Bondarenko
Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214 3078, USA
Am J Physiol Heart Circ Physiol 287:H1378-403. 2004..The attribution of putative molecular bases for several of the component currents enables our mouse model to be used to simulate the behavior of genetically modified transgenic mice...
- Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cellsGuiying Cui
Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
J Physiol 585:791-803. 2007..3 Ca(2+) currents required for auditory transmission...
- Protein phosphatase 1 and an opposing protein kinase regulate steady-state L-type Ca2+ current in mouse cardiac myocytesWilliam H duBell
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Physiol 556:79-93. 2004....
- Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the storeOlivier Thibault
Department of Molecular and Biomedical Pharmacology, University of Kentucky, University of Kentucky Medical Center, Lexington, KY 40536, USA
Aging Cell 6:307-17. 2007..In turn, the increased transients result in dysregulation of multiple Ca2+-dependent processes and, through somewhat different pathways, in accelerated functional decline during aging and AD...
- L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of currentShawn M Crump
Dept of Physiology, MS 508, Univ of Kentucky College of Medicine, 800 Rose St Lexington, KY 40536 0298, USA
Am J Physiol Heart Circ Physiol 291:H1959-71. 2006..We conclude that Rem is capable of regulating L-type current, that release of Rem block is modulated by cellular kinase pathways, and that the Ca(V)1.2 COOH terminus contributes to Rem-dependent channel inhibition...
- Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channelsMartina J Sinnegger-Brauns
Abteilung Pharmakologie und Toxikologie, Institut fur Pharmazie, Universitat Innsbruck, Austria
J Clin Invest 113:1430-9. 2004..This animal model provides a useful tool to elucidate whether Ca(v)1.3-selective channel modulation represents a novel pharmacological approach to modify CNS function without major peripheral effects...
- Transcript scanning reveals novel and extensive splice variations in human l-type voltage-gated calcium channel, Cav1.2 alpha1 subunitZhen Zhi Tang
Department of Physiology, National University of Singapore, Singapore 117597
J Biol Chem 279:44335-43. 2004..This systematic portrait of splice variation furnishes a reference library for comprehending combinatorial arrangements of Cav1.2 splice exons, especially as they impact development, physiology, and disease...
- Functional analysis of congenital stationary night blindness type-2 CACNA1F mutations F742C, G1007R, and R1049WJ B Peloquin
Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary, HMRB 172b, 3330 Hospital Drive Northwest, Calgary, Alberta, Canada T2N 4N1
Neuroscience 150:335-45. 2007..These findings suggest that the pathology of CSNB-2 in patients with these missense mutations in the Ca(v)1.4 calcium channel is the result in either a gain of function (F742C) or a loss of function (G1007R, R1049W)...
- Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79Christophe Altier
Physiopathologie des Canaux Ioniques, Institut de Génétique Humaine CNRS UPR1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
J Biol Chem 277:33598-603. 2002....
- Intramembrane charge movement and L-type calcium current in skeletal muscle fibers isolated from control and mdx miceC Collet
Laboratoire de Physiologie des Elements Excitables, Universite Claude Bernard, F69622 Villeurbanne, France
Biophys J 84:251-65. 2003..They may be speculated to result, at least in part, from remodeling of the submembranous cytoskeleton network due to the absence of dystrophin...
- A novel CACNA1F gene mutation causes Aland Island eye diseaseReetta Jalkanen
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Biomedicum Helsinki, Helsinki, Finland
Invest Ophthalmol Vis Sci 48:2498-502. 2007..The purpose of this study was to identify the mutated gene underlying the disease phenotype in the original AIED-affected family...
- Expression of voltage-dependent calcium channel subunits in the rat retinaHong Ping Xu
Institute of Neurobiology, Fudan University, Shanghai 200433, PR China
Neurosci Lett 329:297-300. 2002..Staining for alpha(1D) was also observed on Müller cells. The differential expression pattern of the alpha(1) subunits suggests that these Ca(2+) channel subtypes may be associated with different retinal functions...
- Molecular characterization of a neuronal low-voltage-activated T-type calcium channelE Perez-Reyes
Department of Physiology, and Cardiovascular Institute, Loyola University Medical Center, Maywood, Illinois 60153, USA
Nature 391:896-900. 1998..Based on the channel's distinctive voltage dependence, slow deactivation kinetics, and 7.5-pS single-channel conductance, we conclude that this channel is a low-voltage-activated T-type calcium channel...
- Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinasesK D Keef
Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
Am J Physiol Cell Physiol 281:C1743-56. 2001....
- Tottering mouse motor dysfunction is abolished on the Purkinje cell degeneration (pcd) mutant backgroundD B Campbell
Department of Neuroscience and Anatomy, Pennsylvania State University College of Medicine, Hershey 17033, USA
Exp Neurol 160:268-78. 1999..These data suggest that the cerebellar cortex, where the mutant gene is abundantly expressed, contributes to the expression of tottering mouse dystonic episodes...
- Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeuticsDobromir Dobrev
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
J Cardiovasc Pharmacol 52:293-9. 2008..This review focuses on the molecular basis of altered Ca handling in AF, with the goal of providing new insights into molecular effective antiarrhythmic therapy...
- Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approachLaura Sartiani
Centro Interuniversitario di Medicina Molecolare e Biofisica Applicata, University of Firenze, Firenze, Italy
Stem Cells 25:1136-44. 2007..In summary, human embryonic stem cell-derived cardiomyocytes mature over time during in vitro differentiation, approaching an adult phenotype. Disclosure of potential conflicts of interest is found at the end of this article...
- Structural determinants of L-type channel activation in segment IIS6 revealed by a retinal disorderAnnette Hohaus
Institute for Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A 1090 Wien
J Biol Chem 280:38471-7. 2005..2. These four residues are completely conserved in high voltage-activated calcium channels suggesting that these channels may share a common mechanism of gating...
- Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15Joanne T Hulme
Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
Proc Natl Acad Sci U S A 100:13093-8. 2003....
- Crucial role of the sarcoplasmic reticulum in the developmental regulation of Ca2+ transients and contraction in cardiomyocytes derived from embryonic stem cellsJi Dong Fu
Laboratory of Molecular Cardiology of Institute of Health Sciences, Shanghai Institutes for Biological Sciences SIBS, Chinese Academy of Sciences CAS and Shanghai Jiao Tong University School of Medicine, Shanghai, China
FASEB J 20:181-3. 2006..We conclude that functional SR and control of RyR2-mediated SR Ca2+ release directly contribute to the spontaneous and beta-adrenergic receptor-stimulated contraction of ESCMs, even at very immature stages of development...
- IP(3) receptor function and localization in myotubes: an unexplored Ca(2+) signaling pathway in skeletal muscleJ A Powell
Department of Biological Sciences, Smith College, Northampton, MA 01063, USA
J Cell Sci 114:3673-83. 2001..These results suggest a signaling system mediated by Ca(2+) and inositol trisphosphate that could regulate gene expression in muscle cells...
- Conformational activation of Ca2+ entry by depolarization of skeletal myotubesGennady Cherednichenko
Department of Molecular Biosciences and Center for Children s Environmental Health and Disease Prevention, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 101:15793-8. 2004..ECCE may provide a fundamental means to rapidly maintain Ca(2+) stores and control important aspects of Ca(2+) signaling in both muscle and nonmuscle cells...
- Growth and function of the embryonic heart depend upon the cardiac-specific L-type calcium channel alpha1 subunitW Rottbauer
Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Dev Cell 1:265-75. 2001..Thus, calcium signaling via C-LTCC can regulate heart growth independently of contraction, and plays distinctive roles in fashioning both form and function of the two developing chambers...
- Thirty distinct CACNA1F mutations in 33 families with incomplete type of XLCSNB and Cacna1f expression profiling in mouse retinaKrisztina Wutz
Abteilung Medizinische Genetik der LMU, Munchen, Germany
Eur J Hum Genet 10:449-56. 2002..Such a distribution points to the central role of calcium regulation in the interaction of retinal cells that mediate signal transmission...
- BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signalingHenrike Berkefeld
Institute of Physiology, University of Freiburg, Hermann Herder Strasse 7, 79104 Freiburg, Germany
Science 314:615-20. 2006..Complex formation with distinct Cav channels enables BKCa-mediated membrane hyperpolarization that controls neuronal firing pattern and release of hormones and transmitters in the central nervous system...
- Mechanisms of [Ca2+]i transient decrease in cardiomyopathy of db/db type 2 diabetic miceLaetitia Pereira
Institut National de la Santé et de la Recherche Médicale U 637, University of Montpellier 1, France
Diabetes 55:608-15. 2006..As less Ca2+ enters the cell through I(Ca), less Ca2+ is released through RyRs...
- Interactions with PDZ proteins are required for L-type calcium channels to activate cAMP response element-binding protein-dependent gene expressionJason P Weick
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 23:3446-56. 2003..Collectively, these data suggest that localized calcium responses, regulated by interactions with PDZ domain proteins, are necessary for L-type calcium channels to effectively activate CREB and CRE-mediated gene expression...
- Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic functionFrancoise Haeseleer
Department of Ophthalmology, University of Washington, Box 356485, Seattle, Washington 98195, USA
Nat Neurosci 7:1079-87. 2004..These observations indicate that CaBP4 is important for normal synaptic function, probably through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals...
- Genomic deletion of estrogen receptors ERalpha and ERbeta does not alter estrogen-mediated inhibition of Ca2+ influx and contraction in murine cardiomyocytesNina D Ullrich
Imperial College London, Cardiac Medicine, National Heart and Lung Institute, London, United Kingdom
Am J Physiol Heart Circ Physiol 294:H2421-7. 2008..Decreases in cell shortening occurred in parallel with these findings. Our results suggest that inhibition of ICaL and the decrease in contraction by estrogens do not depend on ERalpha or ERbeta...
- Molecular identity, synaptic localization, and physiology of calcium channels in retinal bipolar cellsAmy Berntson
John Curtin School of Medical Research, Australian National University, Canberra, Australia
J Neurosci Res 71:146-51. 2003..The L-type current may be mediated by the alpha(1F) subunit, and influx of calcium through the alpha(1F) channel may control neurotransmitter release from the bipolar cell terminal...
- Regulation of insulin secretion in islets of Langerhans by Ca(2+)channelsDavid Mears
Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, USA
J Membr Biol 200:57-66. 2004..The emerging picture is that Ca(2+) channels regulate insulin secretion at multiple sites in the stimulus-secretion coupling pathway, with the specific role of each channel determined by its biophysical and structural properties...
- Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memorySven Moosmang
Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, 80802 Munich, Germany
J Neurosci 25:9883-92. 2005..2 channel-mediated Ca2+ influx to either process...
- Coupled and independent contributions of residues in IS6 and IIS6 to activation gating of CaV1.2Michaela Kudrnac
Department of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A 1090 Wien, Austria
J Biol Chem 284:12276-84. 2009..8 +/- 1.4 mV). Mutant cycle analysis revealed energetic coupling between residues Ser-435 and Ile-781, whereas other paired mutations in segments IS6 and IIS6 had independent effects on activation gating...
- A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in miceZoita Andronache
Institute of Applied Physiology, Ulm University, D 89069 Ulm, Germany
Proc Natl Acad Sci U S A 106:4531-6. 2009....
- Inhibitory control over Ca(2+) sparks via mechanosensitive channels is disrupted in dystrophin deficient muscle but restored by mini-dystrophin expressionMartin D H Teichmann
Medical Biophysics, Department of Systems Physiology, Institute of Physiology and Pathophysiology, Ruprecht Karls University, Heidelberg, Germany
PLoS ONE 3:e3644. 2008..They may be related to mechanosensitive pathways but the mechanisms are elusive. Also, it is not known whether truncated dystrophins can correct the dystrophic disinhibition...
- The three-dimensional structure of the cardiac L-type voltage-gated calcium channel: comparison with the skeletal muscle form reveals a common architectural motifMing Chuan Wang
Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK
J Biol Chem 279:7159-68. 2004..A difference between the cardiac and skeletal muscle ion channels is apparent in the putative transmembrane region, which would be consistent with the absence of the gamma subunit in the cardiac VGCC assembly...
- Probing the architecture of an L-type calcium channel with a charged phenylalkylamine: evidence for a widely open pore and drug trappingStanislav Beyl
Institute for Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A 1090 Vienna, Austria
J Biol Chem 282:3864-70. 2007..The functional data indicating a location of a trapped (-)D888 molecule close to the central pore region are supported by a homology model illustrating that the closed Ca(v)1.2 is able to accommodate a large cation such as (-)D888...
- Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cellsPhilemon S Yang
Ca2 Signals Laboratory, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 26:10677-89. 2006..In particular, the rare subtype CaBP4 is specific to IHCs, and CaBP4 proves capable of eliminating even the potent baseline CDI of Ca(V)1.3. CaBP4 thereby represents a plausible candidate for moderating CDI within IHCs...
- Control of ion conduction in L-type Ca2+ channels by the concerted action of S5-6 regionsSusan M Cibulsky
Department of Pharmacology and Program in Neuroscience, University of Colorado Health Sciences Center, Denver 80262, USA
Biophys J 84:1709-19. 2003..Moreover, the pattern of unitary conductance values obtained for chimeras in which a single P-loop or single S5-6 region was replaced suggest a concerted action of pore-lining regions in the control of ion conduction...
- Voltage-dependent calcium channelsL Lacinova
Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences, Vlarska 5, 833 34 Bratislava 37, Slovakia
Gen Physiol Biophys 24:1-78. 2005..Transfer of 30 % of charge correlates with activation of 70 % of measurable macroscopic current. Prolonged depolarization does not immobilize charge movement of the Ca(v)3.1 channel...
- Temperature dependence of Cav1.4 calcium channel gatingJ B Peloquin
Department of Physiology and Biophysics, Hotchkiss Brain Institute, HMRB 172b, 3330 Hospital Drive Northwest, University of Calgary, Calgary, Alberta, Canada T2N4N1
Neuroscience 151:1066-83. 2008..4 channels observed at near physiological temperatures the window current is preserved and could allow for tonic glutamate release from photoreceptors in the retina during dark adapted conditions...
- G-protein-coupled receptor modulation of striatal CaV1.3 L-type Ca2+ channels is dependent on a Shank-binding domainPatricia A Olson
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Neurosci 25:1050-62. 2005..Together, these results suggest that Shank promotes the assembly of a signaling complex at corticostriatal synapses that enables key GPCRs to regulate L-type Ca2+ channels and the integration of glutamatergic synaptic events...
- Subunit expression of the cardiac L-type calcium channel is differentially regulated in diastolic heart failure of the cardiac allograftR Hullin
Department of Internal Medicine, University Hospital Grobetahadern, Munich, Germany
Circulation 100:155-63. 1999..Multimeric L-type calcium channels (alpha1-, alpha2/delta-, and beta-subunits) are essential for excitation/contraction coupling in the heart. Their gene expression was studied in allografts that developed diastolic heart failure...
- Disulfide bonds, N-glycosylation and transmembrane topology of skeletal muscle triadinH Fan
Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, Florida 33136, USA
Biochemistry 34:14902-8. 1995..The glycosidase endo F/N-glycosidase F changed the mobility of intact triadin in TC/triads and its proteolytic fragments detected by mAb GE4.90.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Location of ryanodine and dihydropyridine receptors in frog myocardiumPierre Tijskens
Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6058, USA
Biophys J 84:1079-92. 2003..Interestingly, the free SR membrane in both heart chambers shows a low but equal density of intramembrane particles representing the Ca(2+) ATPase...
- A small-molecule screen in C. elegans yields a new calcium channel antagonistTrevor C Y Kwok
Department of Medical Genetics and Microbiology, and The Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
Nature 441:91-5. 2006..Our study demonstrates that C. elegans enables rapid identification of new small-molecule tools and their targets...
- Functional properties of ryanodine receptors in hippocampal neurons change during early differentiation in cultureManana Sukhareva
Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
J Neurophysiol 88:1077-87. 2002..The mode of activation of L-type voltage-gated Ca(2+) channels with either membrane depolarization or specific pharmacological agents affects the coupled activity of RyRs differently as neurons differentiate processes and networks...
- The transmembrane domain of syntaxin 1A negatively regulates voltage-sensitive Ca(2+) channelsM Trus
Department of Biological Chemistry, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel
Neuroscience 104:599-607. 2001..Cleavage with botulinum toxin disrupts the coupling of the N- and Lc-type channels with syntaxin 1A and abolishes exocytosis, supporting the hypothesis that these channels actively participate in Ca(2+) regulated secretion...
- Temperature-sensitive intracellular Mg2+ block of L-type Ca2+ channels in cardiac myocytesKaoru Yamaoka
Department of Physiology, School of Medicine, Hiroshima University, Minami Ku, Hiroshima 734 8551, Japan
Am J Physiol Heart Circ Physiol 282:H1092-101. 2002..This effect of phosphorylation together with the inhibitory action of GTP(i) on Mg2+-dependent blocking of I(Ca) are common properties of mammalian and amphibian cardiomyocytes...
- Cytochalasin D reduces Ca2+ currents via cofilin-activated depolymerization of F-actin in guinea-pig cardiomyocytesU Rueckschloss
Department of Physiology, Faculty of Medicine, Martin Luther University, 06097 Halle, Germany
J Physiol 537:363-70. 2001..6. The data support the concept that cytD mediates dephosphorylation and activation of ADF/cofilin, leading to depolymerization of F-actin with a subsequent reduction of I(Ca)...
- A novel long N-terminal isoform of human L-type Ca2+ channel is up-regulated by protein kinase CYakov Blumenstein
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
J Biol Chem 277:3419-23. 2002..The long-NT isoform may be the Ca(2+) channel enhanced by PKC-activating transmitters in human tissues...
- The voltage-gated Ca2+ channel is the Ca2+ sensor of fast neurotransmitter releaseD Atlas
Department of Biological Chemistry, Hebrew University of Jerusalem, Israel
Cell Mol Neurobiol 21:717-31. 2001..The results imply a rapid Ca2+-dependent CAV (RRP) release, initiated by the binding of Ca2+ to the channel, upstream to intracellular Ca2+ sensor thus establishing the Ca2+ channel as the Ca2+ sensor of neurotransmitter release...
- Altered communication between L-type calcium channels and ryanodine receptors in heart failureJean Pierre Benitah
INSERM U 390, Montpellier, France
Front Biosci 7:e263-75. 2002..This theory is supported by new data showing that the T-tubule density is reduced in failing cells...
- The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type calcium channelsCurtis F Barrett
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305 5345, USA
Proc Natl Acad Sci U S A 105:2157-62. 2008..Thus, the TS mutation offers a unique perspective on mechanisms of inactivation as well as a promising starting point for exploring the underlying pathophysiology of autism...
- Molecular physiology of voltage-gated Ca2+ channelsJian Yang; Fiscal Year: 2013..By studying a novel form of activity-dependent fragmentation of VGCCs on the cell membrane, this work may lead to a better understanding of VGCC function and regulation in physiological and pathological conditions. ..
- Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human NeuronsJEN PAN; Fiscal Year: 2013....
- Mineralocorticoid Receptor-Mediated Vascular Insulin ResistanceSHAWN BRADY BENDER; Fiscal Year: 2013..IR will be induced in wild-type and VSMC MR KO mice with a high-fat, high-sucrose diet and will be assessed by glucose tolerance testing. ..
- Chronic stress-induced gene expression in colonic circular smooth muscle cells.Sushil K Sarna; Fiscal Year: 2012..The findings of this proposal are expected to identify the potential molecular therapeutic approaches that may prevent or minimize the ill effects of chronic stress on colonic motility function. ..
- Calcium Signaling, Metabolism, and EC Coupling in HeartJoshua I Goldhaber; Fiscal Year: 2013..This will lead to new therapeutic strategies for preserving heart muscle function, thereby reducing the incidence of heart failure. ..
- Caveolae and mitochondria: A structural interface functionally linking calcium anGREGORY CHARLES AMBERG; Fiscal Year: 2013..The outcome of these experiments will provide mechanistic insights into events underlying arterial dysfunction in obesity and may lead to the development of new rational therapies for managing and preventing cardiovascular disease. ..
- Roles of voltage sensor, S100A1 and calmodulin in skeletal muscle Ca2+ signalingMartin F Schneider; Fiscal Year: 2013..Thus, this project has high impact for multiple disciplines, and for problems of both locomotion and breathing common to a variety of advanced diseased states and aging. ..
- Gonadal Hormones and Depression:The Role of Mood Disorder Risk Gene CACNA1CTodd D Gould; Fiscal Year: 2012....
- VIP-induced gene expression in colonic smooth muscle cellsSushil K Sarna; Fiscal Year: 2010..abstract_text> ..
- AKAP Regulation of Neuronal L-type Calcium Channel Signaling to the NucleusMARK L DELL'ACQUA; Fiscal Year: 2013....
- Neuronal-Specific Splicing of CaV1.2 L-type Calcium ChannelsKristin Webster; Fiscal Year: 2013..I hypothesize that the e1b isoform will more efficiently induce CREB phosphorylation. These experiments will advance our understanding of how neuronal specific isoforms of CaV1.2 contribute to essential neuronal functions. ..
- GABA-B Receptor Modulation of Calcium CurrentsMichelle Mynlieff; Fiscal Year: 2010..but these compounds also cause side effects such as drowsiness, mental slowing, and double vision. By increasing our understanding of the specific effects of GABA, it will be possible to design better drugs for these types of disorders. ..
- CLASSICAL AND ALTERNATIVE PATHWAYS OF FIBRINOLYSISEDWARD FRANKLIN PLOW; Fiscal Year: 2013..Taken together, these studies will define how plasminogen and its receptors function in biologically important responses. ..
- Chemokine receptor-4 regulation of Beta adrenergic-mediated calcium channelSima T Tarzami; Fiscal Year: 2012....
- Analysis of a Novel Regulator of Excitation-Contraction Coupling in Skeletal MuscJohn Y Kuwada; Fiscal Year: 2013..This knowledge should help us better understand the biology of myopathies and could potentially lead to therapeutic agents for congenital myopathies. ..
- Cerebral artery Ca2+ signaling & subarachnoid hemorrhageGeorge Wellman; Fiscal Year: 2009..This study should significantly enhance current knowledge with respect to Ca2+signaling and constriction of cerebral arteries in health and disease and provide insight into possible new therapies for the treatment of cerebral vasospasm. ..
- Manganese-Enhanced MRI Studies of Vision Loss with AgingDAVID PHILIP BISSIG; Fiscal Year: 2013..abstract_text> ..
- Regulation of Cardiac Gene Expression by the L-type Calcium Channel, CaV1.2.ROBERT NATHAN CORRELL; Fiscal Year: 2011..This work will help reveal the role of the cardiac L-type Ca2+ channel in regulation of gene expression related to disease and may suggest new translational strategies to combat heart failure. ..
- Regulation of L-type calcium channels by CaBP4FRANCOISE J HAESELEER; Fiscal Year: 2013..These studies will fill a major void in our understanding of factors controlling photoreceptor Cav1 channels and how dysregulation of these channels may lead to CSNB2 and potentially other visual disorders. ..
- Pathophysiology of dystonia: animal modelsEllen J Hess; Fiscal Year: 2010..Public health relevance: Dystonia is the third most common movement disorder, but current therapies are largely unsatisfactory. The goal is to understand the pathophysiology of dystonia to direct novel treatments. ..
- Secretagogue induced mechanisms regulating islet electrical activityDAVID AARON JACOBSON; Fiscal Year: 2012..Understanding how secretagogues regulate islet electrical activity distinctly from KATP may help to develop new therapies that target specific elements of the excitation-secretion pathway. ..
- Improving Cardiac Regeneration Using Stem Cells with Enhanced Calcium InfluxSharven Taghavi; Fiscal Year: 2012..Once proof of concept studies has been done in mice and if efficacy is shown in the 22a infected stem cells, they will also be tested in a porcine model. ..
- Structure of Channels in Excitation-Contracting CouplingTERENCE C WAGENKNECHT; Fiscal Year: 2013..This proposal will use advanced electron microscopy technology to characterize the structural organization and interactions among these proteins. The findings will be important for understanding normal and diseased muscle function. ..
- Single nucleotide polymorphisms of neuronal CACNA1C L-type calcium channels assocDiane Lipscombe; Fiscal Year: 2011..We will use a combination of RNA, gene, and electrophysiological analyses to reveal the functional role of intron 4 in controlling L-type calcium channel activity in neurons. ..
- L-type Ca2+ Channel Modulation of Beta Cell FunctionGREGORY HOWARD HOCKERMAN; Fiscal Year: 2012..This proposal is consistent with the PI's long term goal of understanding L-type calcium channel modulation and cellular function. ..
- D1 Dopamine Receptor Signaling and Cocaine ReinstatementROBERT CHRISTOPHER PIERCE; Fiscal Year: 2012....
- Role of Calcium Channels in Aging Skeletal MuscleOsvaldo Delbono; Fiscal Year: 2012..Claudia Hereqz at the National University of La Plata, Argentina to elucidate the cellular and molecular mechanisms responsible for the decline in skeletal muscle performance with aging. ..
- Role of L-Type Calcium Channels in Hippocampal Neuronal Network ActivitySCOTT OWEN; Fiscal Year: 2010..We propose here a series of experiments to develop a deeper understanding of how one model of autism spectrum disorder might function at multiple levels from genes to molecules to neural circuits as they function in the brain. ..
- L-type Calcium Channels, Neuronal Excitability &Cognition in Aged MiceGeoffrey G Murphy; Fiscal Year: 2012....
- Fibroblast Growth Factor Homologous Factors: Modulation of L-type Calcium ChannelJESSICA AMENTA HENNESSEY; Fiscal Year: 2013..This will demonstrate that FGF13 is a prominent player in the cardiac action potential through its modulation of the LTCC and define FGF13 dysfunction as a mediator of acquired and inherited arrhythmias. ..
- Coupled Gating of L-type Calcium Channels in HeartLuis F Santana; Fiscal Year: 2013..This work will generate fundamental information on the mechanisms by which AKAP150 and Cav1.2 channels control of excitability, gene expression, and EC coupling in the heart under physiological and pathological conditions. ..
- Dopamine D2 Receptors in Prefrontal Function: An Optogenetic and Modeling StudyIAN THOMAS ELLWOOD; Fiscal Year: 2013..In addition, this model may be used to gain insight into perturbations of normal D2R function that have been hypothesized to underlie psychiatric diseases such as schizophrenia. ..
- Patterning and Formation of the Neuromuscular JunctionWeichun Lin; Fiscal Year: 2013..By identifying these regulatory signals, we may be able to provide additional targets for the development of therapeutic strategies to cure, control, or prevent neurodevelopmental disorders and neurodegenerative diseases. ..
- Analysis of the shocked zebrafish motility mutantJulia Dallman; Fiscal Year: 2009..abstract_text> ..
- L-type Calcium Channel Regulation of Neuronal DifferentiationGeorgia Panagiotakos; Fiscal Year: 2012..These studies will expand our understanding of how activity regulates brain development and will provide new insights into the underlying pathophysiology of autism and mental retardation. ..
- Calcium sparklets-induced vascular dysfunction during diabetesManuel F Navedo; Fiscal Year: 2013....
- Improving Buprenorphine Detoxification Outcomes with IsradipineAlison Oliveto; Fiscal Year: 2013..This would shift clinical practice establishing an effective adjunct regimen for BUP detoxification as well as having the potential to enhance transition to naltrexone therapy. ..
- Modulators of CaV1.3 Ca2+ regulationDavid T Yue; Fiscal Year: 2013..3) To test candidate compounds for modulation of CaV1.3 Ca2+ regulation, using patch-clamp electrophysiology. Overall, this project promises lead candidates for selective modulators of CaV1.3 versus other CaV1 L-type calcium channels. ..
- Pharmacogenetics and Cardiovascular EventsBruce Psaty; Fiscal Year: 2006..The primary defense is replication: we would therefore welcome collaboration from others in the Pharmacogenetics Network in validation efforts. ..
- REGULATION OF NEURONAL CALCIUM CHANNELSJEFFRY LANSMAN; Fiscal Year: 2000..The fourth Aim involves characterizations of the Ca2+i pools mobilized by mGluR1 and muscarinic receptors in granule cells and determine the contribution of store-coupled Ca2+ influx to electrical excitability. ..
- Cardiac Channels: Targets of Drugs that Affect KineticsDorothy A Hanck; Fiscal Year: 2010..Our strategy combines mutagenesis, whole cell, single channel, and gating current electrophysiology, and molecular modeling. ..
- Lipid modulation of beta-cell calcium channelsLina Moitoso de Vargas; Fiscal Year: 2006..We will separate the effects of FFA on different L-type VDCC and determine the effects of FFA on currents through mutant channels generated in Aim 2. ..
- PHYSIOLOGY AND IMMUNOHISTOCHEMISTRY OF DENTAL PULPRobert Davidson; Fiscal Year: 1999..g., growth factors, dexamethasone, or DMSO, and patch-clamp recordings made in parallel with immunohistochemical studies using a monoclonal antibody to the sodium channel itself. ..
- BRAIN MONOAMINES AND LUTEINIZING HORMONE SECRETIONWilliam Crowley; Fiscal Year: 2003..abstract_text> ..
- IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGDonald Bers; Fiscal Year: 2004..This work will greatly increase fundamental understanding of key cardiac Ca transport systems in the intact cellular environment under physiological conditions. ..
- Fetal Coronary Vascular Responses to Long-term HypoxiaRAYMOND GILBERT; Fiscal Year: 2005..Upon completion of the studies, we will have a better understanding of the alteration in fetal coronary artery contractility brought about by exposure to long-term hypoxemia. ..
- Role of MG29 in E-C Coupling of Striated MusclesJianjie Ma; Fiscal Year: 2006..In addition, our studies with the mutant mice will provide new insights into the cellular mechanism of muscle exercise physiology and cardiovascular diseases. ..
- DEVELOPING HEART--BIOPHYSICAL ASPECTSPage Anderson; Fiscal Year: 1999....
- Neurobiology of Self-Injurious BehaviorHYDER JINNAH; Fiscal Year: 2005..These studies have direct relevance for understanding the neuroanatomical and neurochemical basis for self-injurious behavior and direct implications for a potential novel treatment strategy. ..
- Cannabinoid Receptors and Cerebrovascular FunctionCecilia Hillard; Fiscal Year: 2006..Increased understanding of the mediators that are released by activated microglia and their targets may provide new therapeutic approaches to CNS diseases with an inflammatory component. ..
- MUSCARINIC AND ADENOSINE RECEPTOR SIGNAL TRANSDUCTIONRichard Mortensen; Fiscal Year: 2001..These experiments should provide important information on the specificity of signal transduction by G proteins in heart. ..
- REGULATION OF THE CARDIAC CALCIUM CHANNELJames Marsh; Fiscal Year: 1993..Gaining further understanding of mechanisms that regulate calcium channel expression is of fundamental biological importance and will have therapeutic implications...
- L-type Channel Calcium Entry Triggered Diastolic Calcium SparksWILLIAM CECIL LESTER; Fiscal Year: 2010..e. heart failure model). If time allows or if needed, simultaneous whole patch electrophysiology and calcium imaging can be used to dissect the two populations of diastolic sparks in the adult and their voltage dependence. ..
- ALCOHOL MODULATION OF CARDIAC CALCIUM CHANNELSGary Aistrup; Fiscal Year: 2003..This novel action may have major implications, given the widespread clinical use of dihydropyridines and other calcium channel antagonists. Drug interactions of this type will be an important focus of the project. ..
- Rapid Effects of Estradiol in the BrainJill Becker; Fiscal Year: 2007..It may also be important for our understanding and treatment of a number of neurological disorders including stroke, Alzheimer's disease and Parkinson's disease where estradiol may be neuroprotective. ..
- Myocardial Properties of Timothy SyndromeRANDALL RASMUSSON; Fiscal Year: 2009..Patients with Timothy Syndrome die at an average age of 2.5 years. In order to better understand and treat this disorder we will study a mouse in which the same genetic defect has been artificially introduced. ..
- Reorganization of calcium signaling in heart failureSandor Gyorke; Fiscal Year: 2007..abstract_text> ..
- Role of Calcium in Cocaine-Induced SensitizationSTEPHANIE LICATA; Fiscal Year: 2002..Second, rats will receive either acute or repeated cocaine and relative abundance of either calmodulin or CaMKII will be measured in the VTA and substantia nigra using immunolabeling techniques. ..
- GORDON RES CONF: MUSCLE EXCITATION-CONTRACTION COUPLINGDavid MacLennan; Fiscal Year: 2000..The format encourages the exchange of ideas and unpublished data. The organizing committee, with representatives of varying ages from five continents, will strive to achieve appropriate representation of women. minorities and disabled. ..
- RELEASE CHANNEL ISOFORMS AND LOCAL CALCIUM SIGNALINGNatalia Shirokova; Fiscal Year: 2003..Proposed studies will greatly advanced our knowledge of their functioning, which in turn could improve our understanding of their role in decease. ..
- REGULATION OF DEVELOPMENTAL RENAL HEMODYNAMICSMichael Solhaug; Fiscal Year: 2005..Identifying the regulatory relationships between AII and NOS may lead to preventive or therapeutic measures to treat neonatal ARF. ..
- Mechanisms of High Flow Induced VasculopathyElizabeth Jacobs; Fiscal Year: 2007..unreadable] [unreadable]..
- ETHANOL ON CALCIUM CHANNELS AND NMDA RECEPTORSSTEVEN LESLIE; Fiscal Year: 1991..Finally, studies will be conducted to examine the effects of chronic ethanol exposure in adult rats on NMDA- receptor modulation...