ion channels

Summary

Summary: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. Ion channels which are integral parts of ionotropic neurotransmitter receptors are not included.

Top Publications

  1. pmc Glutamate receptor ion channels: structure, regulation, and function
    Stephen F Traynelis
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322 3090, USA
    Pharmacol Rev 62:405-96. 2010
  2. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
  3. ncbi Functional brown adipose tissue in healthy adults
    Kirsi A Virtanen
    Turku PET Center, University of Turku, Finland
    N Engl J Med 360:1518-25. 2009
  4. ncbi Molecular physiology of P2X receptors
    R Alan North
    Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield, United Kingdom
    Physiol Rev 82:1013-67. 2002
  5. ncbi Mitochondrial dysfunction and type 2 diabetes
    Bradford B Lowell
    Department of Medicine, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Harvard Medical School, Boston, MA 02215, USA
    Science 307:384-7. 2005
  6. pmc Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocyt
    Natasa Petrovic
    Wenner Gren Institute, The Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 285:7153-64. 2010
  7. pmc Transcriptional control of brown fat determination by PRDM16
    Patrick Seale
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Cell Metab 6:38-54. 2007
  8. pmc UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
    Zane B Andrews
    Section of Comparative Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Howard Hughes Medical Institute, New York, New York 10021, USA
    Nature 454:846-51. 2008
  9. pmc Functional agonism of insect odorant receptor ion channels
    Patrick L Jones
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Proc Natl Acad Sci U S A 108:8821-5. 2011
  10. pmc Mechanosensitive channels: what can they do and how do they do it?
    Elizabeth S Haswell
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Structure 19:1356-69. 2011

Detail Information

Publications299 found, 100 shown here

  1. pmc Glutamate receptor ion channels: structure, regulation, and function
    Stephen F Traynelis
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322 3090, USA
    Pharmacol Rev 62:405-96. 2010
    The mammalian ionotropic glutamate receptor family encodes 18 gene products that coassemble to form ligand-gated ion channels containing an agonist recognition site, a transmembrane ion permeation pathway, and gating elements that couple ..
  2. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
    ..This receptor is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting ..
  3. ncbi Functional brown adipose tissue in healthy adults
    Kirsi A Virtanen
    Turku PET Center, University of Turku, Finland
    N Engl J Med 360:1518-25. 2009
    ....
  4. ncbi Molecular physiology of P2X receptors
    R Alan North
    Institute of Molecular Physiology, University of Sheffield, Western Bank, Sheffield, United Kingdom
    Physiol Rev 82:1013-67. 2002
    P2X receptors are membrane ion channels that open in response to the binding of extracellular ATP. Seven genes in vertebrates encode P2X receptor subunits, which are 40-50% identical in amino acid sequence...
  5. ncbi Mitochondrial dysfunction and type 2 diabetes
    Bradford B Lowell
    Department of Medicine, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Harvard Medical School, Boston, MA 02215, USA
    Science 307:384-7. 2005
    ..Emerging evidence supports the potentially unifying hypothesis that both of these prominent features of type 2 diabetes are caused by mitochondrial dysfunction...
  6. pmc Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocyt
    Natasa Petrovic
    Wenner Gren Institute, The Arrhenius Laboratories, Stockholm University, SE 106 91 Stockholm, Sweden
    J Biol Chem 285:7153-64. 2010
    ....
  7. pmc Transcriptional control of brown fat determination by PRDM16
    Patrick Seale
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Cell Metab 6:38-54. 2007
    ..PRDM16 activates brown fat cell identity at least in part by simultaneously activating PGC-1alpha and PGC-1beta through direct protein binding. These data indicate that PRDM16 can control the determination of brown fat fate...
  8. pmc UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
    Zane B Andrews
    Section of Comparative Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Howard Hughes Medical Institute, New York, New York 10021, USA
    Nature 454:846-51. 2008
    ..These results reveal a signalling modality connecting mitochondria-mediated effects of G-protein-coupled receptors on neuronal function and associated behaviour...
  9. pmc Functional agonism of insect odorant receptor ion channels
    Patrick L Jones
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Proc Natl Acad Sci U S A 108:8821-5. 2011
    ..Recent reports have characterized insect ORs as ion channels, but the precise mechanism of signaling remains unclear...
  10. pmc Mechanosensitive channels: what can they do and how do they do it?
    Elizabeth S Haswell
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Structure 19:1356-69. 2011
    ....
  11. pmc Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels
    Bertrand Coste
    Department of Cell Biology, The Scripps Research Institute TSRI, La Jolla, CA 92037, USA
    Science 330:55-60. 2010
    ..Piezos are expressed in several tissues, and knockdown of Piezo2 in dorsal root ganglia neurons specifically reduced rapidly adapting MA currents. We propose that Piezos are components of MA cation channels...
  12. ncbi Effect of casein kinase 1α activator pyrvinium pamoate on erythrocyte ion channels
    Yuliya Kucherenko
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
    Cell Physiol Biochem 30:407-17. 2012
    ....
  13. pmc The role of Drosophila Piezo in mechanical nociception
    Sung Eun Kim
    Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 483:209-12. 2012
    Transduction of mechanical stimuli by receptor cells is essential for senses such as hearing, touch and pain. Ion channels have a role in neuronal mechanotransduction in invertebrates; however, functional conservation of these ion ..
  14. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004
    Six members of the mammalian transient receptor potential (TRP) ion channels respond to varied temperature thresholds...
  15. ncbi UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    Helena M Feldmann
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden
    Cell Metab 9:203-9. 2009
    ....
  16. ncbi Lighting up the senses: FM1-43 loading of sensory cells through nonselective ion channels
    Jason R Meyers
    Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 23:4054-65. 2003
    We describe a novel mechanism for vital fluorescent dye entry into sensory cells and neurons: permeation through ion channels. In addition to the slow conventional uptake of styryl dyes by endocytosis, small styryl dyes such as FM1-43 ..
  17. pmc The functional network of ion channels in T lymphocytes
    Michael D Cahalan
    Department of Physiology and Biophysics, and the Institute for Immunology, University of California, Irvine, Irvine, CA 92697 4561, USA
    Immunol Rev 231:59-87. 2009
    ..and functional studies using blockers and genetic manipulation have shown that a unique contingent of ion channels orchestrates the initiation, intensity, and duration of the Ca2+ signal...
  18. ncbi The glutamate receptor ion channels
    R Dingledine
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pharmacol Rev 51:7-61. 1999
  19. pmc Piezo proteins are pore-forming subunits of mechanically activated channels
    Bertrand Coste
    Department of Cell Biology, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 483:176-81. 2012
    ..activated cationic currents in cells; however, it is unknown whether Piezo proteins are pore-forming ion channels or modulate ion channels...
  20. ncbi FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel
    J E Gale
    School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, United Kingdom
    J Neurosci 21:7013-25. 2001
    ..Calcium chelation and FM1-43 both reduce the ototoxic effects of the aminoglycoside antibiotic neomycin sulfate, suggesting that FM1-43 and aminoglycosides enter hair cells via the same pathway...
  21. ncbi The action potential in mammalian central neurons
    Bruce P Bean
    Harvard Medical School, Department of Neurobiology, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Neurosci 8:451-65. 2007
    ..yet mammalian central neurons typically express more than a dozen different types of voltage-dependent ion channels. This rich repertoire of channels allows neurons to encode information by generating action potentials with a ..
  22. ncbi X-ray structure of a prokaryotic pentameric ligand-gated ion channel
    Ricarda J C Hilf
    Department of Biochemistry, University of Zurich, Winterthurer Strasse 190, CH 8057 Zurich, Switzerland
    Nature 452:375-9. 2008
    Pentameric ligand-gated ion channels (pLGICs) are key players in the early events of electrical signal transduction at chemical synapses...
  23. ncbi Cyclic nucleotide-gated ion channels
    U Benjamin Kaupp
    Institut für Biologische Informationsverarbeitung, Forschungszentrum Julich, Julich, Germany
    Physiol Rev 82:769-824. 2002
    ..their activity shows very little voltage dependence, CNG channels belong to the superfamily of voltage-gated ion channels. Like their cousins the voltage-gated K+ channels, CNG channels form heterotetrameric complexes consisting of ..
  24. ncbi Superoxide activates mitochondrial uncoupling proteins
    Karim S Echtay
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Nature 415:96-9. 2002
    ..Our findings indicate that the interaction of superoxide with UCPs may be a mechanism for decreasing the concentrations of reactive oxygen species inside mitochondria...
  25. pmc A voltage-gated proton-selective channel lacking the pore domain
    I Scott Ramsey
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 440:1213-6. 2006
    Voltage changes across the cell membrane control the gating of many cation-selective ion channels. Conserved from bacteria to humans, the voltage-gated-ligand superfamily of ion channels are encoded as polypeptide chains of six ..
  26. ncbi Channel-mediated tonic GABA release from glia
    Soojung Lee
    Center for Neural Science, Korea Institute of Science and Technology KIST, Seoul, Korea
    Science 330:790-6. 2010
    ..Our results identify a molecular mechanism for tonic inhibition and establish a role for interactions between glia and neurons in mediating tonic inhibition...
  27. pmc Crystal structure of the ATP-gated P2X(4) ion channel in the closed state
    Toshimitsu Kawate
    Vollum Institute, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Oregon 97239, USA
    Nature 460:592-8. 2009
    P2X receptors are cation-selective ion channels gated by extracellular ATP, and are implicated in diverse physiological processes, from synaptic transmission to inflammation to the sensing of taste and pain...
  28. pmc Amyloid ion channels: a common structural link for protein-misfolding disease
    Arjan Quist
    Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 102:10427-32. 2005
    ..These ion channels would destabilize cellular ionic homeostasis and hence induce cell pathophysiology and degeneration in amyloid ..
  29. pmc Phylogenetic relationships within cation transporter families of Arabidopsis
    P Maser
    Division of Biology, Cell and Developmental Biology Section and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0116, USA
    Plant Physiol 126:1646-67. 2001
    ..To facilitate their further study, the PlantsT database (http://plantst.sdsc.edu) has been created that includes alignments of the analyzed cation transporters and their chromosomal locations...
  30. ncbi HCN2 ion channels play a central role in inflammatory and neuropathic pain
    Edward C Emery
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
    Science 333:1462-6. 2011
    ..Possible modulators of action potential firing include the HCN ion channels, which generate an inward current, I(h), after hyperpolarization of the membrane...
  31. ncbi The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
    G Barbatelli
    Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, University of Ancona Politecnica delle Marche, Ancona, Italy
    Am J Physiol Endocrinol Metab 298:E1244-53. 2010
    ..Overall, our data strongly suggest that the cold-induced emergence of brown adipocytes in WAT predominantly reflects beta(3)-adrenoceptor-mediated transdifferentiation...
  32. ncbi Ion channels and cancer
    Karl Kunzelmann
    Institut fur Physiologie, Universitat Regensburg, Universitatsstrasse 31, Regensburg, D 93053, Germany
    J Membr Biol 205:159-73. 2005
    Membrane ion channels are essential for cell proliferation and appear to have a role in the development of cancer...
  33. ncbi Pannexin membrane channels are mechanosensitive conduits for ATP
    Li Bao
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    FEBS Lett 572:65-8. 2004
    ..They have a wide expression spectrum, they are of large conductance and permeant for ATP, and they are mechanosensitive. Hence, pannexins are candidates for the release of ATP to the extracellular space upon mechanical stress...
  34. pmc Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk
    Gary R Mirams
    Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford, OX1 3PT, UK
    Cardiovasc Res 91:53-61. 2011
    ..In this study, we investigate whether a simulated evaluation of multi-channel effects could be used to improve this early prediction of TdP risk...
  35. pmc Subunit counting in membrane-bound proteins
    Maximilian H Ulbrich
    Department of Molecular and Cell Biology, University of California, Berkeley Material Science and Physical Bioscience Divisions, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nat Methods 4:319-21. 2007
    ..After testing the method with proteins of known stoichiometry expressed in Xenopus laevis oocytes, we resolved the composition of NMDA receptors composed of NR1 and NR3 subunits...
  36. ncbi Voltage-gated ion channels and gating modifier toxins
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Toxicon 49:124-41. 2007
    ..The voltage-sensor trapping mechanism may be a common mode of action for polypeptide gating modifier toxins acting on all of the voltage-gated ion channels.
  37. pmc Characterization of individual polynucleotide molecules using a membrane channel
    J J Kasianowicz
    Biotechnology Division, National Institute of Science and Technology, Gaithersburg, MD 20899, USA
    Proc Natl Acad Sci U S A 93:13770-3. 1996
    ..Channel blockades can therefore be used to measure polynucleotide length. With further improvements, the method could in principle provide direct, high-speed detection of the sequence of bases in single molecules of DNA or RNA...
  38. pmc IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels
    Anthony J Harmar
    Centres for Cardiovascular Science and Neuroscience Research, The Queen s Medical Research Institute, Institute of Evolutionary Biology, Ashworth Labs, School of Informatics, University of Edinburgh, Edinburgh, UK
    Nucleic Acids Res 37:D680-5. 2009
    ..Links to other bioinformatics resources, such as NCBI, Uniprot, HGNC and the rat and mouse genome databases are provided. IUPHAR-DB is freely available at http://www.iuphar-db.org...
  39. ncbi Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    David D McKemy
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
    Nature 416:52-8. 2002
    ..This cold- and menthol-sensitive receptor, CMR1, is a member of the TRP family of excitatory ion channels, and we propose that it functions as a transducer of cold stimuli in the somatosensory system...
  40. ncbi The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
    Maria Cristina Zingaretti
    Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, Ospedali Riuniti Ancona, University of Ancona Politecnica delle Marche, Ancona, Italy
    FASEB J 23:3113-20. 2009
    ....
  41. pmc Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing
    Gary R Mirams
    Computational Biology, Department of Computer Science, University of Oxford, Oxford, UK
    Br J Pharmacol 167:932-45. 2012
    ..With the advent of high-throughput screening of multiple ion channels in the wet-lab, and improvements in computational modelling of their effects on cardiac cell activity, more ..
  42. ncbi Targeting ion channels in cancer: a novel frontier in antineoplastic therapy
    A Arcangeli
    Department of Experimental Pathology and Oncology, University of Firenze, Italy
    Curr Med Chem 16:66-93. 2009
    ..In this picture, ion channels represent an unexpected, but very promising, player...
  43. pmc Estimating the voltage-dependent free energy change of ion channels using the median voltage for activation
    Sandipan Chowdhury
    Graduate Program in Biophysics, University of Wisconsin Madison, Madison, WI 53706, USA
    J Gen Physiol 139:3-17. 2012
    Voltage-gated ion channels are crucial for electrical activity and chemical signaling in a variety of cell types...
  44. ncbi Uncoupling proteins and the control of mitochondrial reactive oxygen species production
    Ryan J Mailloux
    Department of Biochemistry, Microbiology, and Immunology, University of Ottawa Faculty of Medicine, Ottawa, ON, Canada K1G8M5
    Free Radic Biol Med 51:1106-15. 2011
    ....
  45. ncbi Towards a molecular understanding of adaptive thermogenesis
    B B Lowell
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 404:652-60. 2000
    ..Here we explore these developments in relation to classical physiological views of adaptive thermogenesis...
  46. ncbi Ischemia opens neuronal gap junction hemichannels
    Roger J Thompson
    Department of Psychiatry and Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Science 312:924-7. 2006
    ..Both the current and dye flux were blocked by inhibitors of hemichannels. Therefore, hemichannel opening contributes to the profound ionic dysregulation during stroke and may be a ubiquitous component of ischemic neuronal death...
  47. pmc Ion channels and transporters [corrected] in cancer. 2. Ion channels and the control of cancer cell migration
    Vishnu Anand Cuddapah
    Department of Neurobiology and Center for Glial Biology in Medicine, University of Alabama at Birmingham, USA
    Am J Physiol Cell Physiol 301:C541-9. 2011
    ..A growing body of work suggests that cell migration/invasion is facilitated by ion channels and transporters...
  48. ncbi painless, a Drosophila gene essential for nociception
    W Daniel Tracey
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 113:261-73. 2003
    ..An antibody to Painless binds to localized dendritic structures that we hypothesize are involved in nociceptive signaling...
  49. pmc Localization and targeting of voltage-dependent ion channels in mammalian central neurons
    Helene Vacher
    Department of Neurobiology, Physiology, and Behavior, College of Biological Sciences, University of California, Davis, California 95616 8519, USA
    Physiol Rev 88:1407-47. 2008
    ..and the synaptic input-output relationships of neurons are governed by the action of voltage-dependent ion channels. The localization of specific populations of ion channels with distinct functional properties at discrete sites ..
  50. pmc Pannexin 1 in erythrocytes: function without a gap
    Silviu Locovei
    Department of Physiology and Biophysics, University of Miami Miller School of Medicine, P O Box 016430, Miami, FL 33101, USA
    Proc Natl Acad Sci U S A 103:7655-9. 2006
    ..Furthermore, under conditions of ATP release, erythrocytes took up fluorescent tracer molecules permeant to gap junction channels...
  51. ncbi Structural basis for modulation and agonist specificity of HCN pacemaker channels
    William N Zagotta
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, Box 357290, University of Washington School of Medicine, Seattle, Washington 98195 7290, USA
    Nature 425:200-5. 2003
    ..On the basis of amino acid sequence similarity to HCN channels, the cyclic nucleotide-gated, and eag- and KAT1-related families of channels are probably related to HCN channels in structure and mechanism...
  52. ncbi Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS
    B Santoro
    Center for Neurobiology and Behavior, Departments of Pharmacology and Anesthesiology, and Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    J Neurosci 20:5264-75. 2000
    ..Moreover, in some neurons, specific functional roles can be proposed for I(h) channels with defined subunit composition...
  53. ncbi Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3
    Martin D Brand
    MRC Dunn Human Nutrition Unit, Hills Road, Cambridge, United Kingdom
    Cell Metab 2:85-93. 2005
    ..Evidence that they export fatty acids physiologically is weak. UCP2 and UCP3 are important potential targets for treatment of aging, degenerative diseases, diabetes, and perhaps obesity...
  54. ncbi HOLE: a program for the analysis of the pore dimensions of ion channel structural models
    O S Smart
    Department of Crystallography, Birkbeck College, London, England
    J Mol Graph 14:354-60, 376. 1996
    ..As an example the program is applied to the cholera toxin B-subunit pentamer. The compatibility of the crystal structure and conductance data is established...
  55. pmc NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
    Xuming Zhang
    Department of Pharmacology, University of Cambridge, Cambridge, UK
    EMBO J 24:4211-23. 2005
    ..Phosphorylation of TRPV1 at a single tyrosine residue, Y200, followed by insertion of TRPV1 channels into the surface membrane, explains most of the rapid sensitizing actions of NGF...
  56. ncbi LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability
    M J Nadler
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 411:590-5. 2001
    ..1), a new member of the LTRPC family of putative ion channels. Targeted deletion of LTRPC7 in DT-40 B cells was lethal, indicating that LTRPC7 has a fundamental and ..
  57. ncbi Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel
    Ricarda J C Hilf
    Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nature 457:115-8. 2009
    ..ion channel from Erwinia chrysanthemi (ELIC) has recently provided structural insight into this family of ion channels at high resolution...
  58. pmc Uncoupling proteins 2 and 3 are fundamental for mitochondrial Ca2+ uniport
    Michael Trenker
    Institute of Molecular Biology and Biochemistry, Centre of Molecular Medicine, Medical University of Graz, Harrachgasse 21 III, 8010 Graz, Austria
    Nat Cell Biol 9:445-52. 2007
    ..Moreover, the identification of proteins fundemental for mitochondrial Ca(2+) uptake expands our knowledge of the physiological role for mitochondrial Ca(2+) sequestration...
  59. pmc The small hydrophobic protein of the human respiratory syncytial virus forms pentameric ion channels
    Siok Wan Gan
    School of Biological Sciences, Nanyang Technological University, 637551 Singapore
    J Biol Chem 287:24671-89. 2012
    ..are short (∼100 amino acids) viral membrane proteins that form oligomers of a defined size, act as proton or ion channels, and in general enhance membrane permeability in the host...
  60. pmc Ion channels and transporters in lymphocyte function and immunity
    Stefan Feske
    Department of Pathology, New York University Langone Medical Center, New York, New York 10016, USA
    Nat Rev Immunol 12:532-47. 2012
    Lymphocyte function is regulated by a network of ion channels and transporters in the plasma membrane of B and T cells...
  61. pmc Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching
    Marcelo J Berardi
    Jack and Eileen Connors Structural Biology Laboratory, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 476:109-13. 2011
    ....
  62. pmc Pannexin1 is part of the pore forming unit of the P2X(7) receptor death complex
    Silviu Locovei
    Department of Physiology and Biophysics, University of Miami School of Medicine, 1600 NW 10th Ave, Miami, FL 33136, USA
    FEBS Lett 581:483-8. 2007
    ..Thus, pannexin1 appears to be the molecular substrate for the permeabilization pore (or death receptor channel) recruited into the P2X(7)R signaling complex...
  63. ncbi Ion channels and the hallmarks of cancer
    Natalia Prevarskaya
    INSERM, U800, Laboratoire de Physiologie Cellulaire, Equipe Labellisee par la Ligue Contre le Cancer, Villeneuve d Ascq, F 59650 France
    Trends Mol Med 16:107-21. 2010
    Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and are also involved in the malignant phenotype of cancer cells...
  64. ncbi Hyperpolarization-activated cation currents: from molecules to physiological function
    Richard B Robinson
    Department of Pharmacology, Center for Molecular Therapeutics, Columbia University, New York, NY 10032, USA
    Annu Rev Physiol 65:453-80. 2003
    ..Moreover, we consider selected examples of the expanding physiological functions of Ih with a view toward understanding how the properties of HCN channels contribute to these diverse functional roles...
  65. pmc Ion channels: functional expression and therapeutic potential in cancer. Colloquium on Ion Channels and Cancer
    Scott P Fraser
    Neuroscience Solutions to Cancer Research Group, Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, UK
    EMBO Rep 9:512-5. 2008
  66. ncbi Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology
    H Lin
    Neuroscience Research Institute, University of California, Santa Barbara, California 93016, USA
    FASEB J 15:2433-44. 2001
    ..Thus, AbetaP channels may provide a direct pathway for calcium-dependent AbetaP toxicity in AD...
  67. ncbi Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation
    Stanley Nattel
    Department of Medicine and Research Center, Montreal Heart Institute and Universite de Montreal, Quebec, Canada
    Physiol Rev 87:425-56. 2007
    ..Cardiac disease modifies the operation of ion channels and transporters in a way that promotes the occurrence of cardiac rhythm disturbances, a process called "..
  68. ncbi Ion channels and bacterial infection: the case of beta-barrel pore-forming protein toxins of Staphylococcus aureus
    G Menestrina
    CNR ITC Istituto di Biofisica, Sezione di Trento, Via Sommarive 18, I 38050 Povo, Italy
    FEBS Lett 552:54-60. 2003
    ..gamma-Hemolysin pores seem to be organized as alpha-hemolysin, but should contain an even number of each component, alternating in a 1:1 stoichiometry...
  69. pmc Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice
    Katrine Almind
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:2366-71. 2007
    ..Thus, ectopic deposits of brown adipose tissue in intermuscular depots with regulatable expression of UCP1 provide a genetically based mechanism of protection from weight gain and metabolic syndrome between strains of mice...
  70. ncbi The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus
    Letícia de Almeida Brondani
    Endocrinology Division, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, RS, Brazil
    Arq Bras Endocrinol Metabol 56:215-25. 2012
    ..However, results are still controversial in different populations. Thus, the aim of this study was to review the role of UCP1 in the development of these metabolic diseases...
  71. ncbi Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism
    Sabrina Diano
    Program in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Mol Med 18:52-8. 2012
    ..The goal is to provide a framework for discussion of future therapeutic strategies for metabolism-related chronic diseases...
  72. pmc Integrated allosteric model of voltage gating of HCN channels
    C Altomare
    Dipartimento di Fisiologia e Biochimica Generali, Via Celoria 26, , Via Celoria 16, 20133 Milano, Italy
    J Gen Physiol 117:519-32. 2001
    ..HCN voltage gating thus involves two processes: voltage sensor gating and allosteric opening/closing...
  73. ncbi Ion channels in glial cells
    A Verkhratsky
    School of Biological Sciences, The University of Manchester, Oxford Road, Manchester, UK
    Brain Res Brain Res Rev 32:380-412. 2000
    Functional and molecular analysis of glial voltage- and ligand-gated ion channels underwent tremendous boost over the last 15 years...
  74. ncbi Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels
    Benjamin D Matthews
    Vascular Biology Program, Departments of Pathology and Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Cell Sci 119:508-18. 2006
    ..to the case of the immediate and early responses, but it was also prevented by blocking mechanosensitive ion channels or by inhibiting Src tyrosine kinases...
  75. pmc Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway
    D Della-Morte
    Cerebral Vascular Disease Research Center, Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Neuroscience 159:993-1002. 2009
    ..In conclusion, in vivo resveratrol pretreatment confers neuroprotection similar to IPC via the SIRT1-UCP2 pathway...
  76. ncbi Human brown adipose tissue
    Sven Enerback
    Department of Medical and Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Medicinaregatan 9A, P O Box 440, SE 40530 Goteborg, Sweden
    Cell Metab 11:248-52. 2010
    ..The BAT organ is unique in that it has evolved to safely dissipate large amounts of chemical energy--a quality that might be harnessed to help humans deal with a dangerously hypercaloric environment and still remain in good health...
  77. ncbi Eukaryotic mechanosensitive channels
    Johanna Arnadottir
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Annu Rev Biophys 39:111-37. 2010
    Mechanosensitive ion channels are gated directly by physical stimuli and transduce these stimuli into electrical signals. Several criteria must apply for a channel to be considered mechanically gated...
  78. ncbi MOLE: a Voronoi diagram-based explorer of molecular channels, pores, and tunnels
    Martin Petrek
    National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno Bohunice, Czech Republic
    Structure 15:1357-63. 2007
    ..MOLE is thus a powerful tool for exploring large molecular channels, complex networks of channels, and molecular dynamics trajectories in which analysis of a large number of snapshots is required...
  79. ncbi Genesis and regulation of the heart automaticity
    Matteo E Mangoni
    Institute of Functional Genomics, Department of Physiology, Centre National de la Recherche Scientifique UMR5203, INSERM U661, University of Montpellier I and II, Montpellier, France
    Physiol Rev 88:919-82. 2008
    ..Nevertheless, ion channels and intracellular Ca(2+) signaling are necessary for the proper setting of the pacemaker mechanism...
  80. pmc Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide
    S Chen
    Department of Pharmacology, ColumbiaUniversity, New York, New York 10032, USA
    J Gen Physiol 117:491-504. 2001
    ..Finally, differences in Ih channel properties recorded in cell-free patches versus intact oocytes are shown to be due, in part, to modulation of Ih by basal levels of cAMP in intact cells...
  81. ncbi Mitochondria and Ca(2+) signaling: old guests, new functions
    Wolfgang F Graier
    Molecular and Cellular Physiology Research Unit, MCPRU, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria
    Pflugers Arch 455:375-96. 2007
    ....
  82. pmc Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism
    Zane B Andrews
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 29:14057-65. 2009
    ..Finally, we discuss the potential implications of these studies on the link between obesity and neurodegeneration...
  83. pmc ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
    Jingbo Pi
    Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA
    Toxicol Appl Pharmacol 244:77-83. 2010
    ..In addition, we summarized our recent findings that persistent oxidative stress due to absence of uncoupling protein 2 activates cellular adaptive response which is associated with impaired pancreatic beta-cell function...
  84. ncbi Interdependence of receptor activation and ligand binding in HCN2 pacemaker channels
    Jana Kusch
    Institut fur Physiologie II, Universitatsklinikum Jena, Jena, Germany
    Neuron 67:75-85. 2010
    ....
  85. ncbi Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma
    Gustav Mattiasson
    Wallenberg Neuroscience Center, BMC A13, 221 84 Lund, Sweden
    Nat Med 9:1062-8. 2003
    ..We propose that UCP-2 is an inducible protein that is neuroprotective by activating cellular redox signaling or by inducing mild mitochondrial uncoupling that prevents the release of apoptogenic proteins...
  86. pmc The S4-S5 linker couples voltage sensing and activation of pacemaker channels
    J Chen
    Department of Medicine, Division of Cardiology, Eccles Program in Human Molecular Biology and Genetics, University of Utah, Eccles Institute of Human Genetics, 15 N 2030 E, Room 4220, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 98:11277-82. 2001
    ..Our findings also suggest that opening of HCN and related channels corresponds to activation of a gate located near the inner pore, rather than recovery of channels from a C-type inactivated state...
  87. ncbi Mechanosensitive ion channels: molecules of mechanotransduction
    Boris Martinac
    School of Medicine and Pharmacology, QEII Medical Centre, University of Western Australia, Crawley, WA 6009, Australia
    J Cell Sci 117:2449-60. 2004
    ..presents a major target of the external mechanical forces that act upon a cell, and mechanosensitive (MS) ion channels play a crucial role in the physiology of mechanotransduction...
  88. ncbi Molecular identification of a hyperpolarization-activated channel in sea urchin sperm
    R Gauss
    Institut für Biologische Informationsverarbeitung, Forschungszentrum Julich, Germany
    Nature 393:583-7. 1998
    ..Because of their sequence and functional properties, Ih channels form a class of their own within the superfamily of voltage-gated and cyclic-nucleotide-gated channels...
  89. ncbi Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease
    Zane B Andrews
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 25:184-91. 2005
    ..The present results expose the critical importance of UCP2 in normal nigral dopamine cell metabolism and offer a novel therapeutic target, UCP2, for the prevention/treatment of Parkinson's disease...
  90. ncbi The changed metabolic world with human brown adipose tissue: therapeutic visions
    Jan Nedergaard
    The Wenner Gren Institute, The Arrhenius Laboratories, Stockholm University, SE 10691 Stockholm, Sweden
    Cell Metab 11:268-72. 2010
    ..Adaptive adrenergic thermogenesis in humans represents brown adipose tissue activity, the absence of which may contribute to middle-age obesity...
  91. pmc Uncoupling protein 2 gene polymorphisms are associated with obesity
    Sukma Oktavianthi
    Eijkman Institute for Molecular Biology, Jl, Diponegoro 69, Jakarta, Indonesia
    Cardiovasc Diabetol 11:41. 2012
    ..We examined the association of commonly observed UCP2 G(-866)A (rs659366) and Ala55Val (C > T) (rs660339) single nucleotide polymorphisms (SNPs) with obesity, high fasting plasma glucose, and serum lipids in a Balinese population...
  92. pmc Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels
    Tobias B Huber
    Renal Division, University Hospital Freiburg, 79106 Freiburg, Germany
    Proc Natl Acad Sci U S A 103:17079-86. 2006
    ..Thus, MEC-2, Podocin, and probably many other PHB-domain proteins by binding to themselves, cholesterol, and target proteins regulate the formation and function of large protein-cholesterol supercomplexes in the plasma membrane...
  93. pmc The control of male fertility by spermatozoan ion channels
    Polina V Lishko
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 74:453-75. 2012
    b>Ion channels control the sperm ability to fertilize the egg by regulating sperm maturation in the female reproductive tract and by triggering key sperm physiological responses required for successful fertilization such as hyperactivated ..
  94. ncbi Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    Z Wu
    Dana Farber Cancer Institute, and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 98:115-24. 1999
    ..These data elucidate a pathway that directly links external physiological stimuli to the regulation of mitochondrial biogenesis and function...
  95. pmc Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species
    Charles Affourtit
    Mitochondrial Biology Unit, Medical Research Council, Cambridge CB2 0XY
    Free Radic Biol Med 50:609-16. 2011
    ..Our findings thus provide a mechanistic explanation for the apparently discrepant findings in the field...
  96. ncbi The motor infrastructure: from ion channels to neuronal networks
    Sten Grillner
    Nobel Institute for Neurophysiology, Department of Neuroscience, The Retzius Laboratory, Karolinska Institute, SE 17177 Stockholm, Sweden
    Nat Rev Neurosci 4:573-86. 2003
  97. pmc IUPHAR-DB: new receptors and tools for easy searching and visualization of pharmacological data
    Joanna L Sharman
    University BHF Centre for Cardiovascular Science, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Nucleic Acids Res 39:D534-8. 2011
    ..integrates information on the chemical, genetic, functional and pathophysiological properties of receptors and ion channels, curated and peer-reviewed from the biomedical literature by a network of experts...
  98. pmc Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons
    Christopher J Benson
    Department of Internal Medicine and Psychiatry, and Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 99:2338-43. 2002
    ..These data indicate that combinations of two or more DEG/ENaC subunits coassemble as heteromultimers to generate transient H(+)-gated currents in mouse DRG neurons...
  99. ncbi Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins
    Martin D Brand
    MRC Dunn Human Nutrition Unit, Cambridge CB2 2XY, UK
    Free Radic Biol Med 37:755-67. 2004
    ..More recently evolved roles of uncoupling proteins are in adaptive thermogenesis (UCP1) and perhaps as part of a signaling pathway to regulate insulin secretion in pancreatic beta cells (UCP2)...
  100. ncbi Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons
    J Garcia-Anoveros
    Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 21:2678-86. 2001
    ..Certain BNaC isoforms are expressed exclusively in dorsal root ganglia (DRG) and have been proposed to form the ion channels mediating tissue acidosis-induced pain...
  101. ncbi Uncoupling proteins: the issues from a biochemist point of view
    M Klingenberg
    Institut für Physiologische Chemie der Universität München, Schillerstrasse 44, D 80336 Munich, Germany
    Biochim Biophys Acta 1504:128-43. 2001
    ..In both expression system UCP 2 and 3 are not in or cannot be converted to a functionally native state and thus also for these UCPs a nucleotide regulated H (+) transport is postulated...

Research Grants75

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..of Islet1 in developing sensory neurons can rescue nociceptor survival, but the expression of receptors and ion channels mediating pain pathways have an ongoing requirement for Islet1...
  3. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ....
  4. Roles of Nitric Oxide and Superoxide in Cystitis
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..Hypothesis: Irradiation produces EFAD that activate TRPA1 and TRPV1 ion channels resulting in UC damage and afferent sensitization...
  5. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2013
    ..is to be an independent scientist, and to investigate structural, functional and trafficking aspects of drug-ion channels interactions...
  6. Structural and molecular basis of drug-induced IKACh reduction
    SAMI FOUAD NOUJAIM; Fiscal Year: 2012
    ..is to be an independent scientist, and to investigate structural, functional and trafficking aspects of drug-ion channels interactions...
  7. Ethanol Regulation of Serum Glucocorticoid Kinase I
    BLAIR N COSTIN; Fiscal Year: 2012
    ..The work proposed here could shed light on molecular mechanisms underlying alcoholism and eventually have implications in the development of novel pharmacological agents for alcoholism or alcohol-related neurological disorders. ..
  8. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..abstract_text> ..
  9. Model of Timothy Syndrome to Screen Drugs with Induced Pluripotent Stem Cells
    Masayuki Yazawa; Fiscal Year: 2013
    ..The proposed systems to screen a library of compounds to rescue TS phenotypes will provide a platform to find novel lead compounds that would be clinically useful for the treatment of not only TS but also other cardiac arrhythmias. ..
  10. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..Dramatic changes occur in the expression of neurotransmitter receptors, voltage gated ion channels, inflammatory cytokines, and a variety of other proteins in response to seizure activity...
  11. Antiarrhythmic Mechanisms in the Hearts of Hibernating Mammals
    Lai Hua Xie; Fiscal Year: 2013
    ..Although adaptive alternations in membrane ion channels, Ca handling, connexin expression, and signaling molecules have been reported in hibernating animals, the ..
  12. Conference on Autonomic Regulation of Cardiovascular Function in Health and Disea
    Martin Frank; Fiscal Year: 2012
    ..At least 1 symposium and several talks will be dedicated to sympathetic regulation in humans. These talks will include heart failure, hypertension, POTS, panic disorder and obesity/metabolic syndrome. ..
  13. Interdisciplinary Research Training in Reproduction for Indian Fellows
    John C Herr; Fiscal Year: 2010
    ..and the acrosome reaction, protein transcription, nuclear transcription factors, molecular physiology of ion channels, neuroendocrine control of mechanisms in reproduction, molecular control of spermatogenesis and oogenesis, ..
  14. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ..Although ion channels of the transient receptor potential (TRP) family are known to promote inflammation and pain in somatic models, ..
  15. Protection of Brain Injury from Cyanide Poisoning by Carnosic Acid
    Stuart A Lipton; Fiscal Year: 2013
    ..which were originally discovered in our laboratory, and result in additional activation of NMDAR-operated ion channels, Ca2+ influx, and consequent neuronal damage;these mechanistic considerations account for the fact that anti- ..
  16. Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
    David E Clapham; Fiscal Year: 2013
    ..We hypothesize that hippocampal function is modulated by receptors that activate or potentiate these excitatory ion channels. We have generated mice lacking the TRPC4, TRPC5, both TRPC4 and TRPC5 genes, obtained the TRPC1 knockout mouse,..
  17. Interaction between RNA interference and RNA editing pathways
    Kazuko Nishikura; Fiscal Year: 2013
    ..not directly encoded by the genome can result, as demonstrated with transcripts of glutamate receptor (GluR) ion channels and 5-HT2C serotonin receptors...
  18. Local Calcium Signaling in Pulmonary Arteries
    JAMES SK SHAM; Fiscal Year: 2012
    ..This suggests unique interactions with membrane ion channels. RyRs are modulated by multiple mechanisms...
  19. The Mucolipin TRP Ion Channels
    Haoxing Xu; Fiscal Year: 2013
    The mucolipin family of Transient Receptor Potential (TRPML) proteins is predicted to encode ion channels of intracellular endosomes and lysosomes...
  20. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..or interstitial cystitis (IC/PBS), they participate in both somatic and visceral sensation, express key ion channels that are implicated in somatic and visceral pain (TrpV1, TrpA1), and GFLs can produce analgesia and ..
  21. Targeting thermoreceptors for therapeutic hypothermia
    Sean P Marrelli; Fiscal Year: 2012
    ..These thermoreceptors are believed to include temperature sensitive ion channels of the transient receptor potential (TRP) channel family...
  22. Beta Cell Adaptation to Stress in Baboon Pancreas After Partial Pancreatectomy
    FRANCO BATTISTA FOLLI; Fiscal Year: 2010
    ..microscopy, but rather from intracellular fibril aggregates and soluble oligomers that act as non-selective ion channels. Toxic IAPP fibrils and oligomers share a common structure with Alzheimer Disease (AD)-related [unreadable]-..
  23. Membrane Ion-channels in Helminth Parasites: Anthelmintic Resistance and Sites of
    RICHARD JOHN MARTIN; Fiscal Year: 2011
    ..four aims at our conference: Aim #1: To review recent progress in understanding the actions of anthelmintics at ion channels, and how resistance to those drugs can emerge...
  24. Ionic currents in gastrointestinal smooth muscle
    Hamid I Akbarali; Fiscal Year: 2013
    ..The overall hypothesis is that inflammation induces specific changes in expression, regulation and kinetics of ion channels in smooth muscle cells...
  25. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ..and molecular mechanisms by which cell-surface receptors regulate the function, trafficking, and expression of ion channels. We are particularly interested in receptor regulation of ion channels in pain transduction, as sensitization ..
  26. EFFECT OF LIPIDS ON VASCULAR GRAFT HEALING
    Linda M Graham; Fiscal Year: 2013
    ..and lysoPC increase cellular production of reactive oxygen species, increase cell membrane fluidity, and open ion channels. These effects can inhibit EC migration...
  27. MOUSE MODEL FOR DISEASES OF PROTEIN MISFOLDING
    P Michael Conn; Fiscal Year: 2012
    ..Many mutants retain or regain their fundamental properties as ion channels, enzymes or receptors when re-routed correctly...
  28. Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human Neurons
    JEN PAN; Fiscal Year: 2013
    ..Calcium ion channels are expressed in all excitable and many non-excitable cells to transduce electric signals at the cell membrane ..
  29. Modulation of Colonic Epithelial Permeability by Sex Hormones
    Muriel Larauche; Fiscal Year: 2013
    ..pain and constipation is related to sex-specific alterations of the immune (mast cells) and epithelial (ion channels and secretion, tight junctions and permeability) systems related to sex hormones...
  30. Development of Bioactive Chemical Probes for Calcium-activated Chloride Channel
    Min Li; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Ion channels are membrane proteins, found in both excitable cells and non-excitable cells...
  31. TRP channels in regulation of vascular tone
    David X Zhang; Fiscal Year: 2013
    ....
  32. Mapping Orofacial Nociceptive Pathways and Alterations Due to Inflammation
    JOSHUA EMRICK; Fiscal Year: 2013
    ..Nociceptors are a heterogeneous group;the differential expression of molecules (e.g., ion channels) serves to delineate nociceptor subgroups (e.g...
  33. Function and regulation of elemental Ca2+ signaling in urethral smooth muscle
    Ronghua Zhuge; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ca2+ signals and ion channels are essential in controlling the contraction of smooth muscle in several tissue types and organs...
  34. Effects of nerve demyelination on auditory synaptic functions
    Jun Hee Kim; Fiscal Year: 2012
    ..My main hypothesis is that axons that lose myelin have a disrupted distribution of ion channels, action potentials timing, and an altered handling of Ca2+ and Na+ ion influx...
  35. C. Elegans and Mitochondrial K+ Channels
    KEITH W NEHRKE; Fiscal Year: 2013
    ..In particular, ion channels in the inner mitochondrial membrane that transport potassium (KATP and KCa channels) are believed to attenuate ..
  36. ClC-3 Chloride Ion Channels in Vascular Smooth Muscle
    Fred Lamb; Fiscal Year: 2009
    ..abstract_text> ..
  37. Molecular Mechanisms of Ion Channels in T Lymphocytes
    Michael D Cahalan; Fiscal Year: 2013
    ..Orai channels in the plasma membrane are unrelated to other known ion channels and have unusual characteristics that distinguish them, including a very high degree of selectivity for Ca2+, ..
  38. SIGNAL TRANSDUCTION MECHANISMS OF ERYTHROPOIETIN
    Barbara A Miller; Fiscal Year: 2011
    ..signaling plays an important role in cell proliferation and apoptosis, yet little is known about regulation of ion channels by hematopoietic growth factors...
  39. Mechanisms of Ventricular Tachycardia in Lipotoxic Cardiomyopathy
    JOHN PEARCE MORROW; Fiscal Year: 2013
    ..Dr. Marx is a leader in the field of cardiovascular ion channels. The project will be performed in collaboration with Dr...
  40. Role of Integrins in Bladder Urothelium
    Warren G Hill; Fiscal Year: 2013
    ..Specific aim 2 will investigate how integrins interact with and regulate mechanosensory ion channels within the urothelium using selective inhibitors and ion substitution protocols to determine which ion channels ..
  41. Mechanical and Osmotic Signaling in Chondrocytes
    Farshid Guilak; Fiscal Year: 2013
    ..into articular chondrocytes in response to osmotic or mechanical stimuli is critically dependent on TRPV4 ion channels and is significantly modulated by inflammatory, in particular proteolytic signaling...
  42. Disruption of Autonomic Pathways in Left Atrium by Inhibition of G Proteins
    Alan H Kadish; Fiscal Year: 2010
    ..We propose to use a new method to treat AF, by inhibiting the function of the nerves that are critical to the genesis of this arrhythmia. By using a new inhibitory protein, we will selectively block these nerves in the left atrium. ..
  43. Molecular Physiology of the Epitrachael Endocrine System
    Michael E Adams; Fiscal Year: 2012
    ..cell-specific ablation, RNA gene silencing and cell-specific activation with light or temperature-activated ion channels. We will use several strategies for hypothesis-testing of the roles of specific peptidergic ensembles in ETH-..
  44. Structure and function of Helicobacter pylori VacA
    Timothy L Cover; Fiscal Year: 2013
    ..abstract_text> ..
  45. Role of spectrin/ankyrin-G complex in myocyte signaling and cardiac excitability
    Peter J Mohler; Fiscal Year: 2013
    Project Summary Ion channels and transporters control the movement of charged ions across cell membranes...
  46. Regulation of ENaC in salt-sensitive hypertension via inflammation-induced ROS pr
    TENGIS SANALOVICH PAVLOV; Fiscal Year: 2013
    ..My long-term professional goal is to continue my academic career in the field of biomedical research to study ion channels involved in regulation of salt and water balance at the cellular, organ and systemic levels...
  47. Development and Regulation of Cholinergic Synapses
    Andres Villu Maricq; Fiscal Year: 2013
    ....
  48. Optimization of KCa2 Channel Activators as Neuroscience Tools and Potential Drugs
    Heike Wulff; Fiscal Year: 2012
    ..The best new KCa2 activators will then be evaluated for selectivity over a panel of cloned ion channels and characterized for activity on native KCa2 channels using hippocampal slices...
  49. Transcriptional Networks Regulating Luminal Environment in the Epididymis
    Ann Harris; Fiscal Year: 2013
    ..epididymis the luminal environment is established and maintained through the functional cooperation of multiple ion channels, ion exchangers, solute carriers and transporters, though the mechanisms that coordinate the expression of ..
  50. New Peptides for the Treatment of Multiple Sclerosis
    Christine Beeton; Fiscal Year: 2013
    ..These analogs show enhanced specificity for Kv1.3 over other ion channels while retaining picomolar potency, and they selectively suppress cytokine production and proliferation of human ..
  51. 2011 Mechanisms of Membrane Transport Gordon Research Conference
    Nancy Carrasco; Fiscal Year: 2011
    ..Some transport proteins, called ion channels, exist primarily to send electrical signals by moving ions like K+, Ca2+, or Cl- across the membrane, whereas ..
  52. ELECTROPHYSIOLOGY OF NUCLEAR MEMBRANE INSP3 RECEPTOR
    J Kevin Foskett; Fiscal Year: 2013
    ....
  53. Modulation of insulin and glucagon secretion by GPCR ligands
    TARA ASHLEY SCHWETZ; Fiscal Year: 2011
    ....
  54. MOLECULAR PROPERTIES OF IONIC PERMEABILITY IN NERVE
    Bertil Hille; Fiscal Year: 2013
    ..the kinetics of membrane phosphoinositide metabolism and signaling by G protein coupled receptors to modulate ion channels. The focus includes intracellular membranes and compartments as well as the plasma membrane...
  55. Role of TRPM1 (Melastatin1) in the Biology of Human Melanocytes
    Vijayasaradhi Setaluri; Fiscal Year: 2012
    ..This proposal investigates the role of a unique calcium transporting protein in maintaining proper functioning of human skin melanocytes. Knowledge gained from these studies could help develop new therapies for pigmentary disorders. ..
  56. The bioorganic chemistry of RNA editing by ADARs
    Peter A Beal; Fiscal Year: 2013
    ..Recoding is common in the nervous system with targets including ligand-gated ion channels, voltage-gated ion channels and G-protein coupled receptors...
  57. Circadian Rhythm in Cone Photoreceptors: Cellular Mechanisms
    GLADYS Y KO; Fiscal Year: 2012
    ..of these studies will reveal new mechanisms on miRNAs and integrated Akt-related signaling in the regulation of ion channels and circadian rhythms, and how circadian regulation of photoreceptor L- VGCCs contribute to Ca2+ homeostasis, ..
  58. Spinocerebellar Ataxia Type 2 Gene and Gene Product
    Stefan M Pulst; Fiscal Year: 2012
    ..The proposed experiments address two significant questions relating to SCAs: the importance of ion channels in cerebellar dysfunction and neuronal death in the presence of mutant polyQ proteins and feasibility and ..
  59. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    Kainate receptors are glutamate-gated ion channels that mediate synaptic transmission and regulate cellular excitability in the central nervous system...
  60. Functional Assessment of the Locus for Atrial Fibrillation on Chromosome 4q25
    PATRICK THOMAS ELLINOR; Fiscal Year: 2010
    ..We propose to screen this region of susceptibility in zebrafish, cell lines, and mice for functional elements that may lead to atrial fibrillation. ..
  61. Basal Forebrain Cellular Mechanisms of Cortical Activation
    Robert W McCarley; Fiscal Year: 2013
    ..In the first series of experiments novel 'optogenetic light- activated ion channels will be inserted into specific BF subpopulations (cholinergic and GABAergic neurons containing parvalbumin) to ..
  62. Targeting Injury Pathways to Counteract Pulmonary Agent and Vesicant Toxicity
    Sven Eric Jordt; Fiscal Year: 2013
    ..release to counteract chlorine and vesicant injury, 2: Examine the role of pulmonary and cutaneous TRP ion channels in chemical injury, and 3: Investigate the effects of a p38 kinase antagonist in pulmonary and cutaneous ..
  63. Gender-Differences in Cardiac Repolarization/Arrhythmias
    Guy Salama; Fiscal Year: 2005
    ..Differences in APD diminish after menopause implicating a modulation of ion channels by estrogen and/or testosterone...
  64. Chemical Biodiversity: Investigating the Phylogeny and Functional Toxins of Venom
    MANDE N HOLFORD; Fiscal Year: 2010
    ..provided by applicant): Cellular communication and function depend on electrochemical signals mediated by ion channels and receptors...
  65. GENETIC ANALYSIS OF PAROXYSMAL DYSTONIC CHOREOATHETOSIS
    John Fink; Fiscal Year: 2000
    ..Therefore, only 3 years of funding is recommended in order to be able to evaluate progress. ..
  66. REGULATION OF THE GABA RECEPTOR-CHLORIDE ION CHANNEL
    ROCHELLE SCHWARTZ BLOOM; Fiscal Year: 1991
    ..This research should reveal the importance of these mechanisms in the actions of convulsant and anticonvulsant drugs and in the physiology of seizure activity itself...
  67. ION CHANNELS OF UTERINE MUSCLE DURING PREGNANCY
    Nicholas Sperelakis; Fiscal Year: 1992
    ..The ion channels control the cytosolic Ca2+ level, and hence the contractile sate of the myometrial cells...
  68. Development of a disposable shippable chip for high throughput ion channel screen
    JASON POULOS; Fiscal Year: 2009
    b>Ion channels are important drug targets and unintended drug interactions with ion channels are also of critical importance, requiring the screening of all drug candidates...
  69. High Throughput Assays for Ion Channel Activities of Influenza A & B Viruses
    LAWRENCE PINTO; Fiscal Year: 2006
    ..The assays are based on the high rate of proton conduction of both of these ion channels and involve measurement of either intracellular pH changes in mammalian cells that express the ion channel or ..
  70. Novel Analgesics from Australian Funnel-Web Spider Venom
    MICHAEL NATHAN NITABACH; Fiscal Year: 2010
    ..perception of pain, requires the coordinated participation of a variety of stimulus- and voltage-gated ion channels. Our long-term goal is the development of pharmaceutical agents for interfering with the functions of ion ..
  71. NEUROMODULATION BY ZINC IN THE HIPPOCAMPAL REGION
    John White; Fiscal Year: 2000
    ..Furthermore, zinc exerts effects on many ion channels, some of which may be unique to the hippocampal region...
  72. DEVELOPMENT AND MODULATION OF PRESYNAPTIC ION CHANNELS
    STEPHEN MERINEY; Fiscal Year: 2000
    ..specific areas of research developed in the laboratory over the past two years: (1) development of presynaptic ion channels and their role at cholinergic varicosities in vitro, and (2) somatostatin modulation of neuronal calcium (Ca++ )..
  73. HORMONAL REGULATION OF ION CHANNELS IN MYOMETRIAL CELLS
    Enrico Stefani; Fiscal Year: 1993
    ..This will be important in the medical sciences to determine the role of hormones in the reproductive cycle and to design or improve therapeutic treatment(s) for pathological situations such as premature labor and dysmenorrhea...
  74. STRUCTURE-FUNCTION STUDIES OF A SWITCHABLE ION CHANNEL
    FRANCOISE LEVINTHAL; Fiscal Year: 1991
    The ion channel region of the colicin El protein will be studied as a model for voltage switchable ion channels found in all organisms...
  75. ION CHANNELS AND DEVELOPMENT OF HAIR CELLS
    ALBERT HUDSPETH; Fiscal Year: 2002
    ..response is highly sensitive to the frequency of stimulation as a result of electrical tuning mediated by ion channels in the cell's membrane...