Genomes and Genes
amino acid transport systems
Summary: Cellular proteins and protein complexes that transport amino acids across biological membranes.
Publications301 found, 100 shown here
- A nutrient sensor mechanism controls Drosophila growthJulien Colombani
Institute for Signaling, Developmental Biology and Cancer Research, UMR6543 CNRS Parc Valrose, 06108, Cedex 2, Nice, France
Cell 114:739-49. 2003..Our results demonstrate that the fat body functions as a nutrient sensor that restricts global growth through a humoral mechanism...
- Nitrogen regulation in Saccharomyces cerevisiaeBoris Magasanik
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Gene 290:1-18. 2002..A second focus of the review is the nitrogen regulation of the general amino acid permease, Gap1p, and the proline permease, Put4p, by ubiquitin mediated intracellular protein sorting in the secretory and endosomal pathways...
- A competitive inhibitor traps LeuT in an open-to-out conformationSatinder K Singh
Vollum Institute, Oregon Health and Science University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97239, USA
Science 322:1655-61. 2008....
- The Vam6 GEF controls TORC1 by activating the EGO complexMatteo Binda
Department of Medicine, University of Fribourg, Switzerland
Mol Cell 35:563-73. 2009..Thus, in addition to its regulatory role in homotypic vacuolar fusion and vacuole protein sorting within the HOPS complex, Vam6 also controls TORC1 function by activating the Gtr1 subunit of the EGO complex...
- The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiaeMonica C V Donaton
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Belgium
Mol Microbiol 50:911-29. 2003....
- Arabidopsis AUX1 gene: a permease-like regulator of root gravitropismM J Bennett
Department of Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK
Science 273:948-50. 1996..The cloned AUX1 gene can restore the auxin-responsiveness of transgenic aux1 roots. Spatially, AUX1 is expressed in root apical tissues that regulate root gravitropic curvature...
- Structure and mechanism of an amino acid antiporterXiang Gao
State Key Laboratory of Bio membrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
Science 324:1565-8. 2009..A conserved, acidic pocket opens to the periplasm. Structural and biochemical analysis reveals the essential ligand-binding residues, defines the transport route, and suggests a conserved mechanism for the antiporter activity...
- Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signalingHarinder S Hundal
Division of Molecular Physiology, Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
Am J Physiol Endocrinol Metab 296:E603-13. 2009..We hypothesize (by extrapolation from knowledge of the yeast Ssy1 transceptor) that, at least for SNAT2, the transceptor discriminates between extracellular and intracellular amino acid stimuli when evoking a signal...
- Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptorGriet Van Zeebroeck
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B 3001 Leuven Heverlee, Flanders, Belgium
Nat Chem Biol 5:45-52. 2009..They indicate that signaling requires a ligand-induced specific conformational change that may be part of but does not require the complete transport cycle...
- A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeastMinggeng Gao
Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Nat Cell Biol 8:657-67. 2006..Together, these studies provide evidence that the GSE complex has a key role in trafficking Gap1p out of the endosome and may serve as coat proteins in this process...
- Cell surface polarization during yeast matingMichel Bagnat
Max Planck Institute for Molecular Cell Biology and Genetics, 01307 Dresden, Germany
Proc Natl Acad Sci U S A 99:14183-8. 2002..Our results show that membrane microdomain clustering at the mating projection is involved in the generation and maintenance of polarity during mating...
- Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein dietNina Jansson
Perinatal Center, Institute of Neuroscience and Physiology, Goteborg University, Sweden
J Physiol 576:935-46. 2006..Reduced maternal levels of insulin, leptin and IGF-1 may link maternal protein malnutrition to reduced fetal growth by down-regulation of key placental amino acid transporters...
- Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8K J Roberg
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Genetics 147:1569-84. 1997..The LST7 gene encodes a novel protein. Together, these data indicate that SEC13, LST4, LST7, and LST8 function in the regulated delivery of Gap1p to the cell surface, perhaps as components of a post-Golgi secretory-vesicle coat...
- Peptides induce persistent signaling from endosomes by a nutrient transceptorMarta Rubio-Texeira
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Flanders, Belgium
Nat Chem Biol 8:400-8. 2012..Hence, this work has identified specific dipeptides that cause enhanced proton influx through the Gap1 symporter, resulting in its defective vacuolar sorting, and independently transform it into a persistently signaling transceptor...
- The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permeaseA Schmidt
Department of Biochemistry, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
EMBO J 17:6924-31. 1998..Thus, the TOR nutrient signalling pathway also controls growth by inhibiting a stationary phase (G0) programme. The control of NPR1 by TOR is analogous to the control of p70 s6 kinase and 4E-BP1 by mTOR in mammalian cells...
- Adaptation of plasma membrane amino acid transport mechanisms to physiological demandsStefan Broer
School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, ACT 0200 Canberra, Australia
Pflugers Arch 444:457-66. 2002..Transport mechanisms are not conserved within families and may change with mutation of even a single amino acid residue in the transport protein. Thus transport mechanisms are easily adapted to physiological demands during evolution...
- Amino acid permeases in developing seeds of Vicia faba L.: expression precedes storage protein synthesis and is regulated by amino acid supplyM Miranda
Institut für Pflanzengenetik und Kulturpflanzenforschung IPK, Gatersleben, Germany
Plant J 28:61-71. 2001..Regulation of amino acid transport in relation to storage protein accumulation is discussed...
- Amino acid sensing and mTOR regulation: inside or out?Deborah C I Goberdhan
Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Biochem Soc Trans 37:248-52. 2009..The present review summarizes current ideas and suggests ways in which some of the models proposed might be unified to produce an amino acid detection system that can adapt to environmental change...
- GAP1, the general amino acid permease gene of Saccharomyces cerevisiae. Nucleotide sequence, protein similarity with the other bakers yeast amino acid permeases, and nitrogen catabolite repressionJ C Jauniaux
Laboratoire de Microbiologie, Faculte des Sciences, Universite Libre de Bruxelles, Belgium
Eur J Biochem 190:39-44. 1990..J. Biochem. 133, 135-139]. Northern analysis of GAP1-specific transcripts in wild-type and in mutant strains is in agreement with these views and indicates that nitrogen catabolite repression of GAP1 synthesis occurs at the RNA level...
- Regulation of amino acid transporters by glucose and growth factors in cultured primary human trophoblast cells is mediated by mTOR signalingS Roos
Perinatal Center, Dept of Physiology, Institute of Neuroscience and Physiology, Univ of Gothenburg, P O Box 432, SE 405 30 Gothenburg, Sweden
Am J Physiol Cell Physiol 297:C723-31. 2009..We conclude that the mTOR pathway represents an important intracellular regulatory link between nutrient and growth factor concentrations and amino acid transport in the human placenta...
- Adaptation to diverse nitrogen-limited environments by deletion or extrachromosomal element formation of the GAP1 locusDavid Gresham
Center for Genomics and Systems Biology and Department of Biology, New York University, New York, NY 10003, USA
Proc Natl Acad Sci U S A 107:18551-6. 2010..We propose that this genomic architecture facilitates evolvability of S. cerevisiae populations exposed to variation in levels and sources of environmental nitrogen...
- The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permeaseJ O De Craene
Laboratoire de Physiologie Cellulaire, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, 12 rue des Professeurs Jeneer et Brachet, 6041 Gosselies, Belgium
J Biol Chem 276:43939-48. 2001..Npr1 belongs to a subgroup of protein kinases, some of which are reported to exert a positive control on the activity of other permeases. We propose that these kinases also function as regulators of permease trafficking...
- Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivityH Segawa
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
J Biol Chem 274:19745-51. 1999....
- Increasing amino acid supply in pea embryos reveals specific interactions of N and C metabolism, and highlights the importance of mitochondrial metabolismKathleen Weigelt
Leibniz Institut für Pflanzengenetik und Kulturpflanzenforschung, Gatersleben, Germany
Plant J 55:909-26. 2008..These results demonstrate that legume seeds have a high capacity to regulate N:C ratios, and highlight the importance of mitochondria in the control of N-C balance and amino acid homeostasis...
- Amino acid transporters in the human placentaT Jansson
Perinatal Center, Department of Physiology and Pharmacology, , , Sweden
Pediatr Res 49:141-7. 2001..The primary objective of this review is to integrate the available functional data on placental amino acid transport systems with recent molecular information on mammalian amino acid transporters...
- Conservation of amino acid transporters in fungi, plants and animalsDaniel Wipf
ZMBP, Plant Physiology, Auf der Morgenstelle 1, Eberhard Karls Universitat Tubingen, D 72076, Tubingen, Germany
Trends Biochem Sci 27:139-47. 2002..When used in combination with phylogenetic analyses, functional comparison might aid our prediction of physiological functions for related but uncharacterized open reading frames...
- Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systemsMiguel ConstÃ¢ncia
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom
Proc Natl Acad Sci U S A 102:19219-24. 2005..Thus, crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4, Slc38a2, and Slc2a3) may be a component of the genetic control of nutrient supply and demand during mammalian development...
- Membrane chaperone Shr3 assists in folding amino acid permeases preventing precocious ERADJhansi Kota
Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
J Cell Biol 176:617-28. 2007..Consequently, in cells with impaired ERAD, AAPs are able to attain functional conformations independent of Shr3. These findings illustrate that folding and degradation are tightly coupled processes during membrane protein biogenesis...
- BAP2, a gene encoding a permease for branched-chain amino acids in Saccharomyces cerevisiaeM Grauslund
Department of Yeast Genetics, Carlsberg Laboratory, Copenhagen Valby, Denmark
Biochim Biophys Acta 1269:275-80. 1995....
- Mechanistic aspects of sodium-binding sites in LeuT-like fold symportersCamilo Perez
Max Planck Institute of Biophysics, Structural Biology Department, Max von Laue Strasse 3, D 60438 Frankfurt Main, Germany
Biol Chem 394:641-8. 2013..Moreover, we highlight their crucial roles in conformational changes of LeuT-like fold transporters and their implication on a unifying mechanism in secondary transport...
- Substrate specificity and gene expression of the amino-acid permeases in Saccharomyces cerevisiaeB Regenberg
Department of Yeast Genetics, Carlsberg Laboratory, Copenhagen Valby, Denmark
Curr Genet 36:317-28. 1999..These findings modify the prevalent view that S. cerevisiae only contains one general amino-acid permease, Gap1p, and a number of permeases that are specific for a single or a few amino acids...
- LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasisBin Liu
Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, China
Science 337:351-4. 2012..Thus, LAAT-1 is the lysosomal lysine/arginine transporter, which suggests a molecular explanation for how cysteamine alleviates a lysosomal storage disease...
- Concentrative sorting of secretory cargo proteins into COPII-coated vesiclesPer Malkus
Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
J Cell Biol 159:915-21. 2002..Mutation of a diacidic sequence present in the COOH-terminal cytosolic domain of Gap1p eliminated concentrative sorting of this protein...
- Amino acid transporters in plantsA Ortiz-Lopez
Photosynthesis Research Unit, USDA Agricultural Research Service, University of Illinois Urbana Champaign, 190 ERML, Urbana, IL, USA
Biochim Biophys Acta 1465:275-80. 2000....
- Amino acid transporters: roles in amino acid sensing and signalling in animal cellsRussell Hyde
Division of Molecular Physiology, MSI WTB complex, University of Dundee, Scotland, UK
Biochem J 373:1-18. 2003....
- Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1Madlen Dorn
Institute of Biochemistry Biotechnology, Faculty of Science I, Biozentrum, Martin Luther University Halle Wittenberg, Halle, Germany
J Biol Chem 284:22123-32. 2009..This disulfide bridge is very likely involved in forming or stabilizing the substrate binding site...
- Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)Y Kanai
Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181, Japan
J Biol Chem 273:23629-32. 1998..The cloning of LAT1 is expected to facilitate the research on the protein-protein interaction in the transporter field and to provide a clue to the search for still unidentified transporters...
- Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetesThomas Jansson
Department of Physiology and Pharmacology, The Perinatal Center, Goteborg University, Box 432, S 405 30 Goteborg, Sweden
Diabetes 51:2214-9. 2002..The increased MVM leucine uptake in the GDM/LGA group may contribute to accelerated fetal growth in these patients...
- The proton/amino acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1Isabel Rubio-Aliaga
Molecular Nutrition Unit, Technical University of Munich, Hochfeldweg 2, D 85350 Freising Weihenstephan, Germany
J Biol Chem 279:2754-60. 2004....
- Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell linesO Yanagida
Second Department of Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
Biochim Biophys Acta 1514:291-302. 2001..The properties of the hLAT1/h4F2hc complex would support the roles of this transporter in providing cells with essential amino acids for cell growth and cellular responses, and in distributing amino acid-related compounds...
- Ssy1p and Ptr3p are plasma membrane components of a yeast system that senses extracellular amino acidsH Klasson
Ludwig Institute for Cancer Research, S 171 77 Stockholm, Sweden
Mol Cell Biol 19:5405-16. 1999..These findings suggest that Ssy1p and Ptr3p function in the PM as components of a sensor of extracellular amino acids...
- Activity-dependent reversible inactivation of the general amino acid permeaseApril L Risinger
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Biol Cell 17:4411-9. 2006....
- LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathwayEsther J Chen
Dept of Biology, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
J Cell Biol 161:333-47. 2003..Finally, the different effects of lst8 alleles on the activation of either the Rtg1/3p or Gln3p transcription factors reveal that these two pathways constitute distinct, genetically separable outputs of the Tor-Lst8 regulatory complex...
- Molecular and functional characterization of a family of amino acid transporters from ArabidopsisYan Hua Su
Zentrum fÃ¼r Molekularbiologie der Pflanzen, Pflanzenphysiologie, UniversitÃ¤t TÃ¼bingen, 72076 TÃ¼bingen, Germany
Plant Physiol 136:3104-13. 2004..CAT2 is localized to the tonoplast in transformed Arabidopsis protoplasts and thus may encode the long-sought vacuolar amino acid transporter...
- Novel motifs in amino acid permease genes from LeishmaniaMartin Akerman
Department of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel
Biochem Biophys Res Commun 325:353-66. 2004..Furthermore, the identification of genus-specific motifs in these proteins might be useful to better understand parasite physiology within its hosts...
- PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acidsDeborah C I Goberdhan
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Development 132:2365-75. 2005..As PATH is likely to be saturated in vivo, we propose that one specialised function of high-affinity PAT-related molecules is to maintain growth as local nutrient levels fluctuate during development...
- Arginine-agmatine antiporter in extreme acid resistance in Escherichia coliRam Iyer
Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, USA
J Bacteriol 185:6556-61. 2003..Evidence for a lysine-dependent XAR system in E. coli is also presented. The protection by lysine, however, is milder than that by arginine...
- Subcellular localization and adaptive up-regulation of the System A (SAT2) amino acid transporter in skeletal-muscle cells and adipocytesR Hyde
Division of Molecular Physiology, School of Life Sciences, Medical Sciences Institute Wellcome Trust Biocentre Complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 355:563-8. 2001....
- Amino acid transport across mammalian intestinal and renal epitheliaStefan Broer
School of Biochemistry and Molecular Biology, Australian National University, Canberra, Australian Capital Territory, Australia
Physiol Rev 88:249-86. 2008..With very few exceptions, individual amino acids are transported by more than one transporter, providing backup capacity for absorption in the case of mutational inactivation of a transport system...
- Curing of the [URE3] prion by Btn2p, a Batten disease-related proteinDmitry S Kryndushkin
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0830, USA
EMBO J 27:2725-35. 2008..Btn2p curing requires cell division, and our results suggest that Btn2p is part of a system, reminiscent of the mammalian aggresome, that collects aggregates preventing their efficient distribution to progeny cells...
- ARAMEMNON, a novel database for Arabidopsis integral membrane proteinsRainer Schwacke
Universitat zu Koln, Botanisches Institut, Gyrhofstrasse 15, 50931 Koln, Germany
Plant Physiol 131:16-26. 2003..and incorporated in the ARAMEMNON DB. The ARAMEMNON DB is accessible at the URL http://aramemnon.botanik.uni-koeln.de...
- Function and structure of heterodimeric amino acid transportersC A Wagner
Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
Am J Physiol Cell Physiol 281:C1077-93. 2001....
- Carbon catabolite repression regulates amino acid permeases in Saccharomyces cerevisiae via the TOR signaling pathwayGeorge J Peter
Institute of Urology and Nephrology, University College London, 67 Riding House Street, London W1W 7EY, United Kingdom
J Biol Chem 281:5546-52. 2006..Our results provide novel insights into the regulation of yeast amino acid permeases and signaling mechanisms involved in this regulation...
- Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptakeA Schmidt
Department of Biochemistry, Biozentrum, University of Basel, Switzerland
Mol Cell Biol 14:6597-606. 1994..TAT2 is the tryptophan high-affinity transporter. FK506 does not reduce the levels of TAT1 and TAT2 transcripts, indicating that the inhibition of amino acid transport by the drug is posttranscriptional...
- The amino acid permease AAP8 is important for early seed development in Arabidopsis thalianaRoberto Schmidt
Plant Physiology, Zentrum für Molekularbiologie der Pflanzen, Auf der Morgenstelle 1, 72076 Tubingen, Germany
Planta 226:805-13. 2007..AAP8 plays a crucial role for the uptake of amino acids into the endosperm and supplying the developing embryo with amino acids during early embryogenesis...
- Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiaeTakeshi Uemura
Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
J Biol Chem 282:7733-41. 2007..It was found that DUR3 (but not SAM3) was activated by phosphorylation of Thr(250), Ser(251), and Thr(684) by polyamine transport protein kinase 2...
- Systematic mutational analysis of the intracellular regions of yeast Gap1 permeaseAhmad Merhi
Physiologie Moléculaire de la Cellule, Universite Libre de Bruxelles, Gosselies, Belgium
PLoS ONE 6:e18457. 2011..The NT of Gap1 contains the acceptor lysines for ubiquitylation and its CT includes a sequence essential to exit from the endoplasmic reticulum (ER)...
- Regulation of placental amino acid transporter activity by mammalian target of rapamycinS Roos
Perinatal Center, Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, PO Box 432, Gothenburg SE 405 30, Sweden
Am J Physiol Cell Physiol 296:C142-50. 2009..These data suggest that mTOR regulates placental amino acid transporters by posttranslational modifications or by affecting transporter translocation to the plasma membrane...
- Amino acid transporters are localized to transfer cells of developing pea seedsM Tegeder
Plant Physiology, Zentrum für Molekularbiologie der Pflanzen, Universitat Tubingen, D 72076 Tubingen, Germany
Plant Physiol 122:319-26. 2000..Overall, our observations suggest that this transporter, which is localized in transfer cells of cotyledons, might play a role in the uptake of the full spectrum of amino acids released from seed coats...
- A mutation in amino acid permease AAP6 reduces the amino acid content of the Arabidopsis sieve elements but leaves aphid herbivores unaffectedEmma Hunt
CABI Europe Switzerland, Delémont, CH 2800, Switzerland
J Exp Bot 61:55-64. 2010..The data are discussed in relation to the regulation of phloem composition and the role of phloem amino acids in regulating aphid performance...
- Regulatory mechanisms of SNAT2, an amino acid transporter, in L6 rat skeletal muscle cells by insulin, osmotic shock and amino acid deprivationHitoshi Kashiwagi
Department of Pharmacy, Hokkaido University Hospital, Sapporo, Hokkaido, Japan
Amino Acids 36:219-30. 2009..Western blot and RT-PCR analysis showed an increase in system A at the protein and mRNA levels with each stimulation...
- Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activationS Heublein
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Oncogene 29:4068-79. 2010..Therefore our data are consistent with a model in which PATs modulate the activity of mTORC1 not by transporting amino acids into the cell but by modulating the intracellular response to amino acids...
- Ubiquitin is required for sorting to the vacuole of the yeast general amino acid permease, Gap1O Soetens
Laboratoire de Physiologie Cellulaire, , , 12 rue des Professeurs Jeneer et Brachet, 6041 Gosselies, Belgium
J Biol Chem 276:43949-57. 2001..This result reinforces the growing evidence that ubiquitin plays an important role not only in internalization of plasma membrane proteins but also in their sorting in the endosomes and/or trans-Golgi...
- Ancestry and progeny of nutrient amino acid transportersDmitri Y Boudko
The Whitney Laboratory for Marine Bioscience, University of Florida, 9505 Ocean Shore Boulevard, St Augustine, FL 32080, USA
Proc Natl Acad Sci U S A 102:1360-5. 2005....
- Origins of amino acid transporter loci in trypanosomatid parasitesAndrew P Jackson
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
BMC Evol Biol 7:26. 2007..This study provides a comprehensive phylogenetic account of the origins of these genes, redefining each locus according to a positional criterion, through the integration of phyletic identity with comparative gene order information...
- Aromatic amino acid transporter AAT-9 of Caenorhabditis elegans localizes to neurons and muscle cellsEmilija Veljkovic
Institutes of Physiology and Zoology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
J Biol Chem 279:49268-73. 2004..Taken together, the results show that AAT-9 is expressed in excitable cells of the nematode head and pharynx in which it may provide a pathway for aromatic amino acid transport...
- TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growthKrista M Hennig
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
J Cell Biol 173:963-74. 2006..Our data indicate that endocytosis acts both as an effector function downstream of TOR and as a physiologically relevant regulator of TOR signaling...
- Transport activity-dependent intracellular sorting of the yeast general amino acid permeaseNatalie E Cain
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Biol Cell 22:1919-29. 2011..These results indicate a parsimonious regulatory mechanism by which Gap1p senses its transport substrates to set an appropriate level of transporter activity at the cell surface...
- Anticancer agent E7070 inhibits amino acid and uracil transport in fission yeastK Tsukahara
Tsukuba Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
Mol Pharmacol 60:1254-9. 2001..Thus, some of the molecular targets for E7070 action in S. pombe are likely to be leucine and uracil transporters...
- Renal amino acid transport systems and essential hypertensionVanda Pinto
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, 4200 319 Porto, Portugal
FASEB J 27:2927-38. 2013..The study of the regulation of renal amino acid transporters may help to define the underlying mechanisms predisposing individuals to an increased risk for development of hypertension...
- Role of the sRNA GcvB in regulation of cycA in Escherichia coliSarah C Pulvermacher
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
Microbiology 155:106-14. 2009..However, mutations predicted to disrupt base-pairing between cycA mRNA and GcvB did not alter expression of cycA : : lacZ. A model for GcvB function in cell physiology is discussed...
- Transport of amino acids through the placenta and their roleM A Grillo
Dipartimento di Medicina e Oncologia Sperimentale, Sezione di Biochimica, Universita di Torino, Via Michelangelo 27, 10126 Torino, Italy
Amino Acids 34:517-23. 2008..This occurs for instance for arginine, which gives rise to polyamines and to NO. Interconversion occurs among few other amino acids Transport is altered in pregnancy complications, such as restricted fetal growth...
- The SLC36 family of proton-coupled amino acid transporters and their potential role in drug transportDavid T Thwaites
Epithelial Research Group, Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Br J Pharmacol 164:1802-16. 2011....
- Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: essential role in transport activity and normal control by ubiquitinationElsa Lauwers
Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, B 6041 Gosselies, Belgium
Mol Biol Cell 18:3068-80. 2007..We propose that coupled biogenesis of Gap1 and SLs would create an SL microenvironment essential to the normal conformation, function, and control of ubiquitination of the permease...
- Characterization of anionic amino acid transport systems in mouse mammary glandV K Kansal
Division of Animal Biochemistry, National Dairy Research Institute, Karnal 132 001, India
Indian J Exp Biol 38:1097-103. 2000..Culturing pregnant mouse mammary tissue explants in vitro in the presence of lactogenic hormones (insulin plus cortisol plus prolactin) did not affect appreciably the uptake of L-glutamate...
- SHR3: a novel component of the secretory pathway specifically required for localization of amino acid permeases in yeastP O Ljungdahl
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
Cell 71:463-78. 1992..shr3 mutants constitutively express elevated levels of GCN4, and mutant shr3/shr3 diploids undergo dimorphic transitions that result in filamentous growth at enhanced frequencies...
- Substrate specificity and expression profile of amino acid transporters (AAPs) in ArabidopsisW N Fischer
Institut fur Genbiologische Forschung, Berlin, Germany
J Biol Chem 270:16315-20. 1995..The specific distribution in the plant and the different substrate specificities of AAP transporters may indicate that tissues differ both qualitatively and quantitatively regarding import or export of amino acids...
- Siliques are Red1 from Arabidopsis acts as a bidirectional amino acid transporter that is crucial for the amino acid homeostasis of siliquesFriederike Ladwig
Zentrum für Molekularbiologie der Pflanzen, Plant Physiology, D 72076 Tuebingen, Germany
Plant Physiol 158:1643-55. 2012..Our data demonstrate that the SIAR1-mediated export of amino acids plays an important role in organic nitrogen allocation and particularly in amino acid homeostasis in developing siliques...
- The amino acid permeases AAP3 and AAP6 are involved in root-knot nematode parasitism of ArabidopsisHeather H Marella
Donald Danforth Plant Science Center, St Louis, MO, USA
Mol Plant Microbe Interact 26:44-54. 2013..The transport of amino acids by AAP3 and AAP6 is important for nematode infection and success of the progeny...
- A cryptic role of a glycolytic-gluconeogenic enzyme (aldolase) in amino acid transporter turnover in Aspergillus nidulansKaterina Roumelioti
Institute of Biology, National Center for Scientific Research, Demokritos, Athens, Greece
Fungal Genet Biol 47:254-67. 2010..Our results support a novel role of the FbaA protein that is, involvement in the regulation of amino acids transporters...
- Salt-dependent expression of a nitrate transporter and two amino acid transporter genes in Mesembryanthemum crystallinumOlga V Popova
Department of Physiology and Biochemistry of Plants, Faculty of Biology, University of Bielefeld, 33615 Bielefeld, Germany
Plant Mol Biol 52:569-78. 2003....
- Salt stress-induced proline transporters and salt stress-repressed broad specificity amino acid permeases identified by suppression of a yeast amino acid permease-targeting mutantD Rentsch
Institut fur Genbiologische Forschung, Berlin, Germany
Plant Cell 8:1437-46. 1996..These results corroborate the general finding that under water stress, amino acid export is impaired whereas proline export is increased...
- Ectopic expression of an amino acid transporter (VfAAP1) in seeds of Vicia narbonensis and pea increases storage proteinsHardy Rolletschek
Institut fur Pflanzengenetik und Kulturpflanzenforschung, D 06466 Gatersleben, Germany
Plant Physiol 137:1236-49. 2005..We conclude that seed protein synthesis is nitrogen limited and that seed uptake activity for nitrogen is rate limiting for storage protein synthesis...
- Intracellular trafficking and ubiquitination of the Schizosaccharomyces pombe amino acid permease Aat1pMai Nakase
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki, Fukuoka, Japan
Microbiology 158:659-73. 2012..These results indicate that ubiquitination is an important determinant for localization and regulation of the Aat1p permease in S. pombe...
- Structure of a prokaryotic virtual proton pump at 3.2 A resolutionYiling Fang
Department of Biochemistry, Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02454, USA
Nature 460:1040-3. 2009..2 A resolution. The protein is captured in an outward-open, substrate-free conformation with transmembrane architecture remarkably similar to that seen in four other families of apparently unrelated transport proteins...
- The product of the SHR3 orthologue of Aspergillus nidulans has restricted range of amino acid transporter targetsZ Erpapazoglou
Institute of Biology, National Center for Scientific Research, Demokritos NCSR D, Aghia Paraskevi, 153 10 Athens, Greece
Fungal Genet Biol 43:222-33. 2006..Strongly reduced membrane levels of a PrnB-sGFP fusion in a shrAdelta background clearly suggest a direct role of ShrA in the topogenesis of the proline specific transporter...
- PtAAP11, a high affinity amino acid transporter specifically expressed in differentiating xylem cells of poplarJeremy Couturier
UMR INRA UHP 1136 Interactions Arbres Microorganismes, IFR 110 Ecosystèmes Forestiers, Agroressources, Bioprocédés et Alimentation, Nancy University, Faculte des Sciences et Techniques, BP 70239, F 54506 Vandoeuvre les Nancy Cedex, France
J Exp Bot 61:1671-82. 2010..The present study provides important information highlighting the role of a specific amino acid transporter in xylogenesis in poplar...
- Brief hyperglycaemia in the early pregnant rat increases fetal weight at term by stimulating placental growth and affecting placental nutrient transportAnette Ericsson
Perinatal Center, Institute of Neuroscience and Physiology, Gothenburg University, Box 432, S 405 30 Gothenburg, Sweden
J Physiol 581:1323-32. 2007..We speculate that maternal metabolism in early pregnancy represents a key environmental cue to which the placenta responds in order to match fetal growth rate with the available resources of the mother...
- Modelling and mutational evidence identify the substrate binding site and functional elements in APC amino acid transportersIoannis Vangelatos
Institute of Biology, National Center for Scientific Research Demokritos, Aghia Paraskevi 153 10, Athens, Greece
Mol Membr Biol 26:356-70. 2009....
- Isoforms of amino acid transporters in placental syncytiotrophoblast: plasma membrane localization and potential role in maternal/fetal transportR Cariappa
Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, Box 8116 One Children s Place, St Louis, MO 63110, USA
Placenta 24:713-26. 2003..We hope that this review will stimulate investigation of the properties of trophoblast transporter isoforms, their membrane localization and their contribution to the cellular mechanism of maternal-fetal nutrient transport...
- SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytesSamyuktha Muralidharan Pillai
School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP, United Kingdom
J Biol Chem 286:2455-60. 2011....
- Identification and characterization of a lysosomal transporter for small neutral amino acidsC Sagne
Institut National de la Santé et de la Recherche Médicale U 513, CHU Henri Mondor, 8 rue du General Sarrail, 94010 Creteil Cedex, France
Proc Natl Acad Sci U S A 98:7206-11. 2001..Homology searching in eukaryotic genomes suggests that LYAAT-1 defines a subgroup of lysosomal transporters in the amino acid/auxin permease family...
- Amino acid transport through the Saccharomyces cerevisiae Gap1 permease is controlled by the Ras/cAMP pathwayJinnie M Garrett
Department of Biology, Hamilton College, 198 College Hill Road, Clinton, NY 13323, USA
Int J Biochem Cell Biol 40:496-502. 2008..A mechanism by which the Ras2/cAMP/PKA pathway controls the ubiquitin-dependent degradation of Gap1p is most consistent with the data...
- Amino acid transporters and nutrient-sensing mechanisms: new targets for treating insulin-linked disorders?B Reynolds
Department of Physiology, Anatomy and Genetics, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX, U K
Biochem Soc Trans 35:1215-7. 2007..As our understanding of how nutrient sensing has an impact on IIS/TOR increases, novel targets to modulate aberrant IIS in disease are likely to emerge, which could complement current strategies designed to block kinases in this pathway...
- Leucine induces phosphorylation and activation of p70S6K in cortical neurons via the system L amino acid transporterYuta Ishizuka
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan
J Neurochem 106:934-42. 2008..We propose that leucine plays important roles in regulating signaling by p70S6 kinase by acting as an intercellular communicator in the CNS...
- Seed and vascular expression of a high-affinity transporter for cationic amino acids in ArabidopsisW B Frommer
Institut fur Genbiologische Forschung, Berlin, Germany
Proc Natl Acad Sci U S A 92:12036-40. 1995..AAT1 is specifically expressed in major veins of leaves and roots and in various floral tissues--i.e., and developing seeds...
- Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transportersFredrick J Rosario
Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio, Mail Code 7836, 7703 Floyd Curl Drive, San Antonio, Texas 78229 3900, USA
Endocrinology 152:1119-29. 2011..We speculate that maternal endocrine and metabolic control of placental nutrient transport reduces fetal growth in response to protein restriction...
- K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathwayElsa Lauwers
Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Gosselies, Belgium
J Cell Biol 185:493-502. 2009..Our data reveal that K63-linked Ub chains act as a specific signal for MVB sorting, providing further insight into the Ub code of membrane protein trafficking...
- COPII-cargo interactions direct protein sorting into ER-derived transport vesiclesM J Kuehn
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA
Nature 391:187-90. 1998..Our results indicate that cargo packaging signals and soluble cargo adaptors are recognized by a recruitment complex comprising Sar1-GTP and Sec23/24...
- Transporters for uptake and allocation of organic nitrogen compounds in plantsDoris Rentsch
University of Bern, Institute of Plant Sciences, Altenbergrain 21, 3011 Bern, Switzerland
FEBS Lett 581:2281-9. 2007..The review summarizes our current understanding of the molecular mechanisms of organic nitrogen transport processes, with a focus on amino acid, ureide and peptide transporters...
- Inhibition of cystine uptake disrupts the growth of primary brain tumorsWook Joon Chung
Department of Neurobiology, Civitan International Research Center, The University of Alabama, Birmingham, Alabama 35294 0021, USA
J Neurosci 25:7101-10. 2005..These data suggest that inhibition of cystine uptake into glioma cells through the pharmacological inhibition of system xc- may be a viable therapeutic strategy with a Food and Drug Administration-approved drug already in hand...
- Arginine Availability and Metabolism in the Immune Evasion of H. pyloriKeith T Wilson; Fiscal Year: 2013..These studies will have a major impact on our understanding of H. pylori immunopathogenesis and gastric carcinogenesis, and will lead to new approaches for risk assessment and treatment. ..
- EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUSRichard C Deth; Fiscal Year: 2012..The results will provide an entirely new way of thinking about how drugs of abuse affect the brain and could lead to improved ways to treatment to treat drug addiction. ..
- Development of a mouse model of obesity in pregnancyThomas Jansson; Fiscal Year: 2009....
- Catalytic inactivation of miRNA function by customized RNase P-based ribozymesDANIEL R contact SCHOENBERG; Fiscal Year: 2010..This proposal describes a new approach to inactivating miR-122 using a catalytic RNA enzyme. The long term goal is to apply this strategy to the treatment of HCV infection. ..
- Immunomodulatory effects of arginine supplementation in colitis and colon cancerKeith T Wilson; Fiscal Year: 2013..Through investigation of epithelial and immune function, these studies seek to provide new macronutrient- based strategies for treatment of IBD and prevention of colitis-associated dysplasia and carcinoma. ..
- NITRIC OXIDE AND OXYGENATION IN DIABETIC KIDNEYSNILS AXEL FREDRIK PALM; Fiscal Year: 2010..abstract_text> ..
- Identification of novel system xc- inhibitorsBARBARA STAUCH SLUSHER; Fiscal Year: 2012....
- smFRET Investigation of Gating in a Neurotransmitter Transporter HomologRACHEL ANN KOLSTER; Fiscal Year: 2013..Furthermore, the single-molecule methods developed in this proposal will aid in the establishment of a platform for single-molecule imaging of other membrane proteins, including the human NSS, in situ on the cell membrane. ..
- Alcohol Abuse and HIV-1: Mechanisms of Combined CNS Injury and InterventionsYuri Persidsky; Fiscal Year: 2012..Current proposal aims to understand mechanisms of combined effects of HIV-1 and alcohol abuse in the brain and to propose neuroprotective therapies. ..
- Maternal pro-inflammatory status in obesity regulates placental functionTheresa L Powell; Fiscal Year: 2013..This is highly relevant to public health since this new information may lead to novel intervention strategies to alleviate fetal overgrowth, which could lessen the epidemic of obesity and diabetes in the next generation. ..
- Extracellular pH modulation by Candida albicans in vitro and in vivoMichael C Lorenz; Fiscal Year: 2013..Finally, we will use live cell imaging to dissect the intracellular trafficking of C. albicans in the macrophage and determine the role of alkalinization and ammonia release in modulating endocytic maturation. ..
- Mechanisms and Interventions for Methamphetamine and HIV-1 Induced CNS InjuryYuri Persidsky; Fiscal Year: 2013..abstract_text> ..
- Initiation and Regulation of Chronic Autoimmune Prostate InflammationTimothy L Ratliff; Fiscal Year: 2013....
- Role of System xc in Asbestos Induced Autoimmune ResponsesJEAN COOPER PFAU; Fiscal Year: 2010..Because asbestos causes oxidative stress, this project will test the hypothesis that System xc- plays a major role in the altered immune responses that lead to autoantibody production. ..
- Altered transport and epigenomic changes in maneb-potentiated neurotoxicityJAMES R ROEDE; Fiscal Year: 2012..This project is designed to test this hypothesis. ..
- Altered transport and epigenomic changes in maneb-potentiated neurotoxicityJAMES R ROEDE; Fiscal Year: 2013..The proposed research will meet these goals and foster the development of my independent research career. ..
- Olivocerebellar Circuitry in AutismGene J Blatt; Fiscal Year: 2010..abstract_text> ..
- mechanisms of HIV and drug abuse pathogenesis in CNSLena Al-Harthi; Fiscal Year: 2013....
- Molecular Pathogenesis of Skeletal Muscle AtrophyChristopher M Adams; Fiscal Year: 2013..abstract_text> ..
- Ethanol Dependence, Drinking &Mechanisms Regulating Accumbal Glutamate ActivityVorani Ramachandra; Fiscal Year: 2013..abstract_text> ..
- ROLE OF CD98 IN INTESTINAL PERMEABILITYDidier Merlin; Fiscal Year: 2012..S, suffer from inflammatory bowel disease. New therapeutic strategies based on a better understanding of the pathogenesis of IBD will improve the clinical care of patient with this disorder. ..
- Molecular Mechanisms Regulating Placental Nutrient TransportersThomas Jansson; Fiscal Year: 2013..Furthermore, we propose a novel model for the regulation of amino acid transporters in the human placenta. ..
- Control of nuclear thyroid hormone signaling by cell surface proteinsDANIEL RICHARD BUCHHOLZ; Fiscal Year: 2010..Thus, knowledge of developmental roles of LAT1 is important when considering use of drugs targeting LAT1 to evaluate potential benefits and side-effects. ..
- Translational Control by NutrientsMaria Hatzoglou; Fiscal Year: 2010..The proposed studies aim to identify these proteins and characterize how they activate the IRES. This is the first report on the regulation of the activity of the IRES by nutrients. ..
- Novel Chemotherapeutics for Brain TumorsBernd Jandeleit; Fiscal Year: 2013..In projected Phase 2 studies, successful compounds will be tested in vivo in validated xenograft models for various brain tumors. ..
- Molecular Genetics of Regulated Protein Delivery of the Plasma MembraneCHRIS ALAN KAISER; Fiscal Year: 2010..A final aim of the project is (iv) to understand how ubiquitination is regulated and to identify the cellular components required for recognition of the ubiquitin tag. ..
- Regulation of System xc- by Interleukin-1 betaNICOLE ALYSE JACKMAN; Fiscal Year: 2010..Successful completion of this proposal will advance and refine our knowledge about an important new therapeutic target (system xc-) that complements other ongoing efforts to reduce injury associated with oxidative stress. ..
- Nutrient regulation of amino acid transporters in aging human skeletal muscleMicah J Drummond; Fiscal Year: 2013..The pilot data collected will be used for future R01 submissions to identify mechanisms and novel targets for interventions to improve muscle function and preserve physical independence in older adults. ..
- Development of Novel Fluorinated Amino AcidsMark Goodman; Fiscal Year: 2004..carrier-mediated facilitated transport involving either the "L" large-neutral amino acid or "A" alanine amino acid transport systems. Preliminary evaluation of amino acids labeled with positron emitters and which are substrates for the "..
- Emory Molecular and Translational Imaging CenterCarolyn C Meltzer; Fiscal Year: 2012..abstract_text> ..
- Regulation of System xc- by Interleukin-1BetaNicole Jackman; Fiscal Year: 2009..Successful completion of this proposal will advance and refine our knowledge about an important new therapeutic target (system xc-) that complements other ongoing efforts to reduce neurological injury associated with oxidative stress. ..
- Characterization of amino acid transport- and signaling in the mosquito fat bodyImmo Alex Hansen; Fiscal Year: 2013..In addition, this study will expand our knowledge of the functional mechanism of cationic amino acid transporter in insects with implications for understanding essential amino acid transporters in humans and other model systems. ..
- A Controlled Trial of NAC for Cocaine DependenceRobert Malcolm; Fiscal Year: 2009..placebo;and 3) to study cocaine craving/cue reactivity and withdrawal symptoms in subjects taking NAC or placebo. ..
- Regulation of GABAergic Neuron DifferentiationBrian Condie; Fiscal Year: 2005..The proposed experiments will lead to new insights into the co-ordinate regulation of GABAergic neuron differentiation during fetal development. ..
- GLUTAMATE TRANSPORT IN EXCITOTOXIC CELL DEATHMargaret Sutherland; Fiscal Year: 1999..Primary cortical cultures from wild type (+/+) and EAAT2 transgenic mice will be used to quantitate changes in neuronal survival under normal and hypoxic conditions (Specific Aim 2). ..
- NEW RETROVIRAL RECEPTORS/HOST RESISTANCESDavid Kabat; Fiscal Year: 2004..These investigations build on a technological breakthrough and will substantially expand our understanding of human and animal retroviral diseases and of host resistance mechanisms. ..
- Control of Cardiac Metabolism: NADH Shuttles/HypertrophyThomas Scholz; Fiscal Year: 2006..A complete understanding of this pathway is essential to fully define the interaction between these two compartments. [unreadable] [unreadable]..
- Microvascular Regulation During Intestinal AbsorptionHAROLD G BOHLEN; Fiscal Year: 2010..A substantial fraction of the NO in blood may be from NO loading in the small arteries based on their very high wall NO concentration and represents a new form of vascular regulation. ..
- DEVELOPMENT OF AMINO ACID TRANSPORT IN EARLY EMBRYOSLON VAN WINKLE; Fiscal Year: 1993The purpose of the proposed studies is to examine the interrelationships among amino acid transport systems in mouse oocytes, ova and preimplantation conceptuses and intra-and extracellular amino acid concentrations...
- AMINO ACID TRANSPORTER B: PHARMACOLOGY & THERAPEUTIC USEMalliga Ganapathy; Fiscal Year: 2006....
- BLOOD BRAIN BARRIER LARGE NEUTRAL AMINO ACID TRANSPORTERWilliam Pardridge; Fiscal Year: 2003..These studies will provide new molecular biological information on a crucial transporter at the blood-brain barrier that regulates the supply in the brain of essential amino acids. ..
- HYPOXIA INHIBITS L-ARGININE UPTAKE BY LUNG ENDOTHELIUMEdward Block; Fiscal Year: 2007..unreadable]..
- DEVELOPMENT OF NEUROPROTECTIVE DRUGS FOR RETINAL DISEASEScott Eliasof; Fiscal Year: 2000..abstract_text> ..
- Function and High-Resolution of an APC superfamily amino acid transporterBliss Forbush; Fiscal Year: 2009....
- MECHANISMS OF INHERITED MEMBRANE TRANSPORT DISORDERSStanton Segal; Fiscal Year: 1992..Bovee and Segal, Project 5, Examination of Human Intestinal Amino Acid Transport Systems, Dr. McNamara, Project 6, Ontogeny and Regulation of Transport in Renal Membranes, Dr...
- YEAST AMINO ACID PERMEASESJANETTA GARRETT; Fiscal Year: 2000..Tryptophan uptake is of particular interest because there are many unusual phenotypes associated with low tryptophan levels in yeast. There are also interesting parallels between yeast tryptophan uptake and auxin response in plants. ..
- NITRIC OXIDE AND OXYGENATION IN DIABETIC KIDNEYSNILS PALM; Fiscal Year: 2007..unreadable] [unreadable]..
- FUNCTIONS OF RETROVIRAL RECEPTORS TRANSPORTERSDavid Kabat; Fiscal Year: 2001..5) Analyze the role of glycosylation in blocking infection of hamster cells by ecotropic and amphotropic mouse retroviruses. ..
- STRUCTURE AND FUNCTION OF MEMBRANE PROTEINSWilliam Dowhan; Fiscal Year: 2004..The proposed experiments are expected to define at the molecular level the role of PE and other lipids in the assembly, organization, and function of polytopic membrane proteins. ..
- Role of arginase in allergic airway inflammationMARC ROTHENBERG; Fiscal Year: 2007..It is anticipated that the proposed studies will shed new light on the pathogenesis of experimental asthma and provide a rationale for possible novel therapeutic and diagnostic interventions in asthma. ..
- Mechanism of Arginine Transport in Cardiac MyocytesRUBEN PELUFFO; Fiscal Year: 2009..Altogether, these studies will provide a detailed picture of the molecular events that take place during cationic amino acid transport into cells and how regulatory mechanisms may alter transport function. ..
- ABERRANT TRANSCRIPTS IN AGE RELATED NEURAL DISORDERSChien Liang Lin; Fiscal Year: 1999..abstract_text> ..
- Dynamic regulation of inhibitory synaptic transmission through GABA metabolismGREGORY MATHEWS; Fiscal Year: 2009....
- REGULATION OF AMINO ACID TRANSPORT IN ERYTHROID CELLSJAYDUTT VADGAMA; Fiscal Year: 1990..We will first identify and characterize the various amino acid transport systems which may be expressed at specific stages of development...
- RECEPTOR AND TRANSPORTER REGULATION OF NO SYNTHASESRICHARD VENEMA; Fiscal Year: 2002..Finally, we will test the hypothesis that the iNOS-CAT2 interaction facilitates NO release from vascular smooth muscle cells and will define the domains in the two proteins that are involved in the interaction. ..
- Microarray Discovery of Hepatic BiomarkersBonnie Lau; Fiscal Year: 2009..It is predicted that genes involved in oxidant and metabolic stress responses, such as LAT1, will be central in adaptation following liver injury. ..
- RAS CONTROL OF AMINO ACID TRANSPORT IN YEASTJANETTA GARRETT; Fiscal Year: 1992..These assays are designed to determine the mechanism of coordination between general signals for cell growth and the transport of nitrogen compounds into the cell. ..
- Solution NMR Studies of an ATP-Binding CassetteChunyu Wang; Fiscal Year: 2003..abstract_text> ..
- Characterization of a novel endosomal sorting complexERIC SPEAR; Fiscal Year: 2007..unreadable] [unreadable]..
- Novel, in Vivo Measures of Rat Spinal Cord GlutamateSusan Queen; Fiscal Year: 2007..It will be essential to validate the technique in rat spinal cord prior to application of the method to spinal cord injury. [unreadable] [unreadable]..
- AMINO ACID TRANSPORT SYSTEMS IN SKELETAL MUSCLEPatricia King; Fiscal Year: 1992..Further scientific data for the CRISP System are unavailable at this time...
- Excitatory Amino Acid Transporter Expression and Regulation in SchizophreniaDeborah Bauer; Fiscal Year: 2008..Defining the specific abnormalities in glutamatergic neurotransmission may be used to target more effective diagnostic and treatment strategies. [unreadable] [unreadable] [unreadable]..