gtp binding proteins

Summary

Summary: Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.

Top Publications

  1. ncbi The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:389-99. 1992
  2. ncbi Rho GTPases and the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Science 279:509-14. 1998
  3. ncbi Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
    K Kimura
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630 01, Japan
    Science 273:245-8. 1996
  4. ncbi G proteins: transducers of receptor-generated signals
    A G Gilman
    Annu Rev Biochem 56:615-49. 1987
  5. ncbi The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:401-10. 1992
  6. ncbi Inositol trisphosphate and calcium signalling
    M J Berridge
    AFRC Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Nature 361:315-25. 1993
  7. ncbi G protein signaling events are activated at the leading edge of chemotactic cells
    C A Parent
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 95:81-91. 1998
  8. ncbi Exportin 1 (Crm1p) is an essential nuclear export factor
    K Stade
    Department of Biochemistry and Biophysics, University of California at San Francisco, 94143 0414, USA
    Cell 90:1041-50. 1997
  9. pmc RanGAP1 induces GTPase activity of nuclear Ras-related Ran
    F R Bischoff
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 91:2587-91. 1994
  10. pmc Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    Miles Parkes
    Inflammatory Bowel Disease Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Genet 39:830-2. 2007

Detail Information

Publications307 found, 100 shown here

  1. ncbi The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:389-99. 1992
    ..These data imply that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors...
  2. ncbi Rho GTPases and the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Science 279:509-14. 1998
    ....
  3. ncbi Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
    K Kimura
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630 01, Japan
    Science 273:245-8. 1996
    ..Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase...
  4. ncbi G proteins: transducers of receptor-generated signals
    A G Gilman
    Annu Rev Biochem 56:615-49. 1987
  5. ncbi The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:401-10. 1992
    ..We propose that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin...
  6. ncbi Inositol trisphosphate and calcium signalling
    M J Berridge
    AFRC Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, UK
    Nature 361:315-25. 1993
    ..Such a dynamic signalling pathway controls many cellular processes, including fertilization, cell growth, transformation, secretion, smooth muscle contraction, sensory perception and neuronal signalling...
  7. ncbi G protein signaling events are activated at the leading edge of chemotactic cells
    C A Parent
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 95:81-91. 1998
    ....
  8. ncbi Exportin 1 (Crm1p) is an essential nuclear export factor
    K Stade
    Department of Biochemistry and Biophysics, University of California at San Francisco, 94143 0414, USA
    Cell 90:1041-50. 1997
    ..cerevisiae. The presented data are consistent with the conclusion that Crm1p is a carrier for the NES-mediated protein export pathway. We propose CRM1 be renamed exportin 1 (XPO1)...
  9. pmc RanGAP1 induces GTPase activity of nuclear Ras-related Ran
    F R Bischoff
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 91:2587-91. 1994
    ..It was purified from HeLa cell lysates and induces GTPase activity of Ran, but not Ras, by more than 3 orders of magnitude. The Ran mutant Q69L, modeled after RasQ61L, which is unable to hydrolyze bound GTP, is insensitive to RanGAP1...
  10. pmc Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    Miles Parkes
    Inflammatory Bowel Disease Research Group, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Nat Genet 39:830-2. 2007
    ..We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13...
  11. ncbi Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
    L Luo
    Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco 94143
    Genes Dev 8:1787-802. 1994
    ..Expressions of analogous mutant Dcdc42 proteins cause qualitatively distinct morphological defects, suggesting that similar GTPases in the same subfamily have unique roles in morphogenesis...
  12. pmc Regulation of eukaryotic translation by the RACK1 protein: a platform for signalling molecules on the ribosome
    Jakob Nilsson
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    EMBO Rep 5:1137-41. 2004
    ..In addition, the fact that RACK1 associates with membrane-bound receptors indicates that it promotes the docking of ribosomes at sites where local translation is required, such as focal adhesions...
  13. pmc Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
    T Matsui
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma, Japan
    EMBO J 15:2208-16. 1996
    ..Thus it is likely that Rho-kinase is a putative target serine/threonine kinase for Rho and serves as a mediator of the Rho-dependent signaling pathway...
  14. ncbi Immune control of tuberculosis by IFN-gamma-inducible LRG-47
    John D MacMicking
    Laboratory of Infection Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 302:654-9. 2003
    ..Thus, LRG-47 may serve as a critical vacuolar trafficking component used to dispose of intracellular pathogens like Mtb...
  15. pmc A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
    Matthew R Whorton
    Department of Pharmacology, University of Michigan Medical School, MI 48109, USA
    Proc Natl Acad Sci U S A 104:7682-7. 2007
    ....
  16. ncbi Arabidopsis interdigitating cell growth requires two antagonistic pathways with opposing action on cell morphogenesis
    Ying Fu
    Center for Plant Cell Biology, Institute for Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA
    Cell 120:687-700. 2005
    ..We propose that the counteractivity of these two pathways demarcates outgrowing and indenting cortical domains, coordinating a process that gives rise to interdigitations between adjacent pavement cells...
  17. pmc The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase
    T Ishizaki
    Department of Pharmacology, Kyoto University Faculty of Medicine, Japan
    EMBO J 15:1885-93. 1996
    ..When co-expressed with RhoA in COS cells, p160 was co-precipitated with the expressed Rho and its kinase activity was activated, indicating that p160 can associate physically and functionally with Rho both in vitro and in vivo...
  18. pmc Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin
    S S Akimov
    Department of Biochemistry, American Red Cross, Rockville, Maryland 20855, USA
    J Cell Biol 148:825-38. 2000
    ..Together our results demonstrate that tissue transglutaminase mediates the interaction of integrins with fibronectin, thereby acting as an integrin-associated coreceptor to promote cell adhesion and spreading...
  19. ncbi CRM1 is an export receptor for leucine-rich nuclear export signals
    M Fornerod
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 90:1051-60. 1997
    ..We conclude that CRM1 is an export receptor for leucine-rich nuclear export signals and discuss a model for the role of RanGTP in CRM1 function and in nuclear export in general...
  20. ncbi The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation
    K Barrett
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown 02129, USA
    Cell 91:905-15. 1997
    ..Together, these results establish a Rho-mediated signaling pathway that is essential for the major morphogenetic events in Drosophila gastrulation...
  21. pmc Identification of different roles for RanGDP and RanGTP in nuclear protein import
    D Gorlich
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Germany
    EMBO J 15:5584-94. 1996
    ..Thus, binding of nucleoplasmic RanGTP to importin-beta probably triggers termination, i.e. the dissociation of importin-alpha from importin-beta and the subsequent release of the import substrate into the nucleoplasm...
  22. pmc Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection
    C M Collazo
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 194:181-8. 2001
    ..In addition, both strains displayed normal clearance of MCMV. Thus, LRG-47 and IRG-47 have vital, but distinct roles in immune defense against protozoan and bacterial infections...
  23. ncbi Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
    P J Keely
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599 7365, USA
    Nature 390:632-6. 1997
    ..PI(3)K inhibition also disrupts actin structures, suggesting that activation of PI(3)K by Cdc42 and Rac1 alters actin organization, leading to increased motility and invasiveness...
  24. ncbi A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
    T Yokomizo
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Japan
    Nature 387:620-4. 1997
    ..Our findings, together with previous reports, show that LTB4 is a unique lipid mediator that interacts with both cell-surface and nuclear receptors...
  25. ncbi GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits
    D M Berman
    Department of Pharmacology University of Texas Southwestern Medical Center Dallas 75235, USA
    Cell 86:445-52. 1996
    ..RGS4 activates the GTPase activity of certain Gi alpha 1 mutants (e.g., R178C), but not others (e.g., Q204L). The GAP activity of RGS proteins is consistent with their proposed role as negative regulators of G protein-mediated signaling...
  26. ncbi The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
    Robert Fredriksson
    Department of Neuroscience, Biomedical Center, Box 593, 75 124 Uppsala, Sweden
    Mol Pharmacol 63:1256-72. 2003
    ..Our novel approach of analyzing such large and diverse sequence sets may be useful for studies on GPCRs in other genomes and divergent protein families...
  27. ncbi Human IRGM induces autophagy to eliminate intracellular mycobacteria
    Sudha B Singh
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Science 313:1438-41. 2006
    ..We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load...
  28. ncbi The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
    C S Hill
    Transcription Laboratory, Imperial Cancer Research Fund Laboratories, London, England
    Cell 81:1159-70. 1995
    ..Functional Rho is required for regulated activity of the c-fos promoter. These results establish SRF as a nuclear target of a novel Rho-mediated signaling pathway...
  29. ncbi Processing of Mgm1 by the rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA
    Mark Herlan
    Adolf Butenandt Institut für Physiologische Chemie, Ludwig Maximilians Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
    J Biol Chem 278:27781-8. 2003
    ..Therefore, processing of l-Mgm1 by Pcp1 and the presence of both isoforms of Mgm1 appear crucial for wild type mitochondrial morphology and maintenance of mitochondrial DNA...
  30. ncbi A role for Rac in Tiam1-induced membrane ruffling and invasion
    F Michiels
    The Netherlands Cancer Institute, Division of Cell Biology, Amsterdam
    Nature 375:338-40. 1995
    ..Moreover, T-lymphoma cells expressing V12Rac1 become invasive, indicating that the Tiam1-Rac signalling pathway could be operating in the invasion and metastasis of tumour cells...
  31. ncbi Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis
    M Evangelista
    Institute of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Science 276:118-22. 1997
    ..Both Bni1p and Bud6p (like Cdc42p and actin) localized to the tips of mating projections. Bni1p may function as a Cdc42p target that links the pheromone response pathway to the actin cytoskeleton...
  32. ncbi Microtubule minus-end anchorage at centrosomal and non-centrosomal sites: the role of ninein
    M M Mogensen
    Department of Anatomy and Physiology, MSI WTB complex, Dow Street, University of Dundee, Dundee, DD1 5EH, UK
    J Cell Sci 113:3013-23. 2000
    ..We propose that ninein is a non-nucleating microtubule minus-end associated protein which may have a dual role as a minus-end capping and anchoring protein...
  33. ncbi Transglutaminase 2: an enigmatic enzyme with diverse functions
    Laszlo Fesus
    Dept of Biochemistry and Molecular Biology, Faculty of Medicine, Medical and Health Science Center, University of Debrecen, H 4012, Debrecen, Hungary
    Trends Biochem Sci 27:534-9. 2002
    ..An important role for the enzyme in the pathogenesis of coeliac disease, fibrosis and neurodegenerative disorders has also been demonstrated, making TG2 an important therapeutic target...
  34. pmc Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii
    Julia P Hunn
    Department of Cell Genetics, Institute for Genetics, University of Cologne, Cologne, Germany
    EMBO J 27:2495-509. 2008
    ..Accumulation of IRG proteins at the PVM has previously been shown to be associated with a block in pathogen replication: our results relate for the first time the enzymatic properties of IRG proteins to their role in pathogen resistance...
  35. ncbi Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system
    M Schaefer
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Cell 107:183-94. 2001
    ..Thus, asymmetric activation of heterotrimeric G proteins by a receptor-independent mechanism may orient asymmetric cell divisions in different cell types...
  36. pmc The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
    T Leung
    Glaxo IMCB Group, Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Mol Cell Biol 16:5313-27. 1996
    ....
  37. ncbi EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins
    M R Koelle
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 84:115-25. 1996
    ..Two previously known and 13 newly identified mammalian genes have similarity to egl-10 and SST2, and we propose that members of this family regulate many G protein signaling pathways...
  38. ncbi Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells
    M A Sells
    Fox Chase Cancer Centre, 7701 Burholme Avenue, Philadelphia, Pennsylvania 19111, USA
    Curr Biol 7:202-10. 1997
    ..This kinase is therefore a candidate effector for the changes in cell shape induced by growth factors...
  39. pmc The G protein beta subunit is essential for multiple responses to chemoattractants in Dictyostelium
    L Wu
    Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 129:1667-75. 1995
    ..Interestingly, the g beta- cells grow at the same rate as wild-type cells in axenic medium but grow more slowly on bacterial lawns and, therefore, may be defective in phagocytosis...
  40. pmc Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
    Steven A McCarroll
    Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Nat Genet 40:1107-12. 2008
    ..These results suggest that the CD association at IRGM arises from an alteration in IRGM regulation that affects the efficacy of autophagy and identify a common deletion polymorphism as a likely causal variant...
  41. ncbi Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis
    Andrea Hutterer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Dev Cell 6:845-54. 2004
    ..On the basolateral side, Lgl is active and excludes Par-6 from the cell cortex, suggesting that complementary cortical domains are maintained by mutual inhibition of aPKC and Lgl on opposite sides of an epithelial cell...
  42. pmc Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
    E Manser
    Glaxo IMCB Group, Institute of Molecular and Cell Biology, National University of Singapore, Kent Ridge
    Mol Cell Biol 17:1129-43. 1997
    ..These data support our previous suggestions of a role for PAK downstream of both Cdc42 and Rac1 and indicate that PAK functions include the dissolution of stress fibers and reorganization of focal complexes...
  43. ncbi RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone
    Susanne Schoch
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    Nature 415:321-6. 2002
    ..These data indicate that RIM1alpha has a central function in integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitter release...
  44. ncbi EEA1 links PI(3)K function to Rab5 regulation of endosome fusion
    A Simonsen
    Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Oslo
    Nature 394:494-8. 1998
    ....
  45. ncbi G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival
    Julie Radeff-Huang
    Department of Pharmacology, University of California San Diego, La Jolla, California 92093, USA
    J Cell Biochem 92:949-66. 2004
    ....
  46. ncbi Interferon-induced mx proteins: dynamin-like GTPases with antiviral activity
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Traffic 3:710-7. 2002
    ..As a consequence, these viral components are trapped and sorted to locations where they become unavailable for the generation of new virus particles...
  47. pmc Transglutaminase 2 undergoes a large conformational change upon activation
    Daniel M Pinkas
    Department of Chemical Engineering, Stanford University, Stanford, California, United States of America
    PLoS Biol 5:e327. 2007
    ....
  48. pmc The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses
    Terrence M Tumpey
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 81:10818-21. 2007
    ..Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses...
  49. ncbi The GTPase superfamily: conserved structure and molecular mechanism
    H R Bourne
    Department of Pharmacology, University of California, San Francisco 94143 0450
    Nature 349:117-27. 1991
    ....
  50. pmc Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis
    J Lippincott
    Department of Cell Biology, Harvard Medical School, Boston, Massachussetts 02115, USA
    J Cell Biol 140:355-66. 1998
    ....
  51. pmc The PCH family protein, Cdc15p, recruits two F-actin nucleation pathways to coordinate cytokinetic actin ring formation in Schizosaccharomyces pombe
    Robert H Carnahan
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Biol 162:851-62. 2003
    ..We propose a model in which Cdc15p plays a critical role in recruiting and coordinating the pathways essential for the assembly of medially located F-actin filaments and construction of the CAR...
  52. ncbi The GTPase superfamily: a conserved switch for diverse cell functions
    H R Bourne
    Department of Pharmacology, University of California, San Francisco 94143
    Nature 348:125-32. 1990
    ....
  53. ncbi Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion
    H Stenmark
    European Molecular Biology Laboratory, Heidelberg Federal Republic of Germany
    Cell 83:423-32. 1995
    ..Immunodepletion of rabaptin-5 from cytosol strongly inhibits Rab5-dependent early endosome fusion. Rabaptin-5 is thus a Rab effector required for membrane docking and fusion...
  54. ncbi In vivo functional characterization of the Saccharomyces cerevisiae 60S biogenesis GTPase Nog1
    Jennifer L Fuentes
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, 830 North University Avenue, Ann Arbor, MI 48109, USA
    Mol Genet Genomics 278:105-23. 2007
    ..Several conserved charge-to-alanine substitutions outside the GTPase domain display modest growth phenotypes indicating that these residues are not critical for function...
  55. pmc A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways
    Y Horii
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    EMBO J 13:4776-86. 1994
    ..Of the tissues examined, expression of ost was the highest in brain and could be localized to neurons and alpha-tanycytes, suggesting that Ost may participate in axonal transport in these specialized cells...
  56. pmc Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization
    Joseph N McLaughlin
    Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 104:5662-7. 2007
    ..Because PAR3 is a critical determinant of PAR1 function, targeting of PAR3 may mitigate the effects of PAR1 in activating endothelial responses such as vascular inflammation...
  57. pmc Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene
    Daniel Grimm
    Department of Virology, University of Freiburg, Hermann Herder Strasse 11, 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 104:6806-11. 2007
    ..These results reveal a surprisingly simple concept of how influenza viruses may gain virulence and illustrate that high speed of virus growth can outcompete the antiviral response of the infected host...
  58. ncbi Transglutaminase overexpression sensitizes neuronal cell lines to apoptosis by increasing mitochondrial membrane potential and cellular oxidative stress
    Mauro Piacentini
    Department of Biology, University of Rome Tor Vergata Rome, Italy
    J Neurochem 81:1061-72. 2002
    ..These results could also be of pathogenetic relevance for those diseases that are characterized by increased tTG and apoptotic rate together with impaired mitochondrial function, e.g. in some neurodegenerative disease...
  59. ncbi Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast
    D W Pruyne
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 143:1931-45. 1998
    ..Therefore, actin cables respond to polarity cues independently of the overall distribution of cortical patches and are able to directly target the Myo2p-dependent delivery of secretory vesicles and polarization of growth...
  60. ncbi Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction
    Yan Xu
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Biochim Biophys Acta 1582:81-8. 2002
    ..The signaling and ligand-binding properties of these receptors are reviewed here. These discoveries provide an intriguing opportunity and a novel approach in studying the pathophysiological roles of SPC and LPC and their receptors...
  61. ncbi Association of the Rho family small GTP-binding proteins with Rho GDP dissociation inhibitor (Rho GDI) in Saccharomyces cerevisiae
    G Koch
    Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita, Japan
    Oncogene 15:417-22. 1997
    ..These results indicate that yeast Rho GDI possesses properties similar to those of mammalian Rho GDI, and that there is a cytosolic factor which functionally substitutes for Rho GDI in yeast...
  62. ncbi Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
    H Miki
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, Japan
    Nature 391:93-6. 1998
    ..This activation seems to be caused by exposure of N-WASP's actin-depolymerizing region induced by Cdc42 binding...
  63. ncbi The Drosophila gastrulation gene concertina encodes a G alpha-like protein
    S Parks
    Department of Molecular Biology, Princeton University, New Jersey 08540
    Cell 64:447-58. 1991
    ..The phenotype of embryos from homozygous cta mothers suggests that the cta gene plays a role in a signal transduction pathway used during gastrulation...
  64. ncbi The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
    C Bucci
    European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 70:715-28. 1992
    ..We conclude that rab5 is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway...
  65. ncbi The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors
    Pierfrancesco Vargiu
    Instituto de Investigaciones Biomédicas Alberto Sols Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, 28029 Madrid, Spain
    Oncogene 23:559-68. 2004
    ..Overall, our results provide the initial insights into the role in signal transduction of this novel Ras family member...
  66. pmc Dynamics of receptor/G protein coupling in living cells
    Peter Hein
    Department of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    EMBO J 24:4106-14. 2005
    ..Our data suggest that alpha(2A)-adrenergic receptors and G proteins interact by rapid collision coupling and indicate that there is no significant precoupling between these receptors and G proteins...
  67. ncbi It takes two to tango: regulation of G proteins by dimerization
    Raphael Gasper
    Max Planck Institut fur molekulare Physiologie, Abteilung Strukturelle Biologie, Dortmund, Germany
    Nat Rev Mol Cell Biol 10:423-9. 2009
    ..We propose that the juxtaposition of the G domains of two monomers across the GTP-binding sites activates the biological function of these proteins and the GTPase reaction...
  68. pmc Rhes is involved in striatal function
    Daniela Spano
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Mol Cell Biol 24:5788-96. 2004
    ..These results suggest that Rhes disruption affects selected behavioral competencies...
  69. ncbi IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression
    Stephan Brand
    Department of Medicine II, University Hospital Munich Grosshadern, University of Munich, D 81377 Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 289:G960-8. 2005
    ....
  70. pmc Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids
    G Kochs
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Proc Natl Acad Sci U S A 96:2082-6. 1999
    ..Our results reveal an antiviral mechanism whereby an interferon-induced protein traps the incoming virus and interferes with proper transport of the viral genome to its ultimate target compartment within the infected cell...
  71. ncbi Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
    K Takahashi
    Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita 565, Japan
    J Biol Chem 272:23371-5. 1997
    ..These results suggest that ERM as well as Rho GDI and the Rho GDP/GTP exchange factor are involved in the activation of the Rho subfamily members, which then regulate reorganization of actin filaments through the ERM system...
  72. pmc RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth
    Weizhou Zhang
    Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Mol Cell Biol 26:413-24. 2006
    ..We conclude that RACK1 mediates recruitment of STAT3 to IR and IGF-1R specifically for activation, suggesting a general paradigm for the need of an adaptor in mediating activation of STATs by receptor protein tyrosine kinases...
  73. ncbi Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors
    Roland Seifert
    Department of Pharmacology and Toxicology, The University of Kansas, Malott Hall, Room 5064, 1251 Wescoe Hall Drive, 5064 Malott Hall, Lawrence, KS 66045 7582, USA
    Naunyn Schmiedebergs Arch Pharmacol 366:381-416. 2002
    ..Inverse agonists may be useful in the treatment of neuropsychiatric and cardiovascular diseases and of diseases caused by constitutively active GPCR mutants...
  74. pmc ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae
    E Bi
    Department of Biology, University of North Carolina, Chapel Hill 27599, USA
    Mol Cell Biol 16:5264-75. 1996
    ..As ZDS1 and ZDS2 have recently been identified also by numerous other groups studying a wide range of biological phenomena, the roles of Cdc42p in intracellular signaling may be more diverse than has previously been appreciated...
  75. pmc Small G proteins in islet beta-cell function
    Anjaneyulu Kowluru
    Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48202 3489, USA
    Endocr Rev 31:52-78. 2010
    ..Potential significance of these experimental observations from multiple laboratories and possible avenues for future research in this area of islet research are highlighted...
  76. ncbi A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose
    L Kraakman
    Laboratorium voor Moleculaire Celbiologie, Katholieke Universiteit Leuven, Institute of Botany and Microbiology
    Mol Microbiol 32:1002-12. 1999
    ..This appears to be the first example of a GPCR system activated by a nutrient in eukaryotic cells. Hence, a subfamily of GPCRs might be involved in nutrient sensing...
  77. ncbi Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach
    R J Palomino-Morales
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada, Spain
    Genes Immun 10:356-64. 2009
    ..014, pooled OR=1.13). In conclusion, our results confirm the ATG16L1 rs2241880 and IRGM rs13361189 and rs4958847 polymorphisms as important markers for CD susceptibility and indicate that these variants are also associated with UC...
  78. ncbi Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration
    Patrick A Kiely
    Department of Biochemistry, Biosciences Institute, University College Cork, Ireland
    J Biol Chem 283:22952-61. 2008
    ..Taken together, the data demonstrate that Tyr-302 in RACK1 is required for interaction with PP2A and beta1 integrin, for regulation of PP2A activity, and for IGF-I-mediated cell migration and proliferation...
  79. ncbi Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles
    A Mayer
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire, 03755 3844 USA
    Cell 85:83-94. 1996
    ..Sec17p and Sec18p thus may function in a predocking stage of the reaction, rather than in bilayer fusion per se...
  80. ncbi Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling
    S S Ferguson
    The John P Robarts Research Institute and Department of Physiology, University of Western Ontario, London, Ontario, Canada
    Pharmacol Rev 53:1-24. 2001
    ..Similar to what is observed for GPCR desensitization and resensitization, beta-arrestin-dependent GPCR internalization is involved in the intracellular compartmentalization of these protein complexes...
  81. pmc Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway
    P M Pryciak
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, Worcester Foundation Campus, Shrewsbury, Massachusetts 01545, USA
    Genes Dev 12:2684-97. 1998
    ..Moreover, our results suggest that this event promotes kinase cascade activation by delivering the Ste5-associated kinases to the cell surface kinase Ste20, whose function may depend on Cdc42 and Cdc24...
  82. ncbi Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product
    M J Hart
    Department of Biochemistry, Cornell University, Ithaca, New York 14853
    Nature 354:311-4. 1991
    ....
  83. ncbi G proteins in development
    Craig C Malbon
    Department of Pharmacology, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794 8651, USA
    Nat Rev Mol Cell Biol 6:689-701. 2005
    ..The convergence of developmental biology with cell signalling has now revealed overlaps in which G proteins mediate complex pathways in embryonic development...
  84. pmc A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells
    S B Su
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702 1201, USA
    J Exp Med 189:395-402. 1999
    ..In contrast, SAA was not a ligand or agonist for FPR, the high affinity fMLP receptor. Thus, SAA is the first chemotactic ligand identified for FPRL1. Our results suggest that FPRL1 mediates phagocyte migration in response to SAA...
  85. ncbi Small GTP-binding proteins and the regulation of the actin cytoskeleton
    A Hall
    MRC Laboratory for Molecular Cell Biology, University College London, England
    Annu Rev Cell Biol 10:31-54. 1994
  86. pmc Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein Cdc42p and its activator CDC24
    Z S Zhao
    Institute of Molecular and Cell Biology, National University of Singapore, Kent Ridge
    Mol Cell Biol 15:5246-57. 1995
    ..The two-hybrid system revealed that Ste4p interacts with Cdc24p. We propose that Cdc42p plays a pivotal role both in polarization of the cytoskeleton and in pheromone signalling...
  87. ncbi Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1
    S Kuroda
    Division of Signal Transduction, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma 630 01, Japan
    J Biol Chem 271:23363-7. 1996
    ..Moreover, IQGAP was accumulated at the cell-cell junction in MDCK cells, where alpha-catenin and ZO-1 were localized. These results suggest that IQGAP is a novel target molecule for Cdc42 and Rac1...
  88. ncbi Six GTP-binding proteins of the Era/Obg family are essential for cell growth in Bacillus subtilis
    Takuya Morimoto
    Department of Microbial Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0101, Japan
    Microbiology 148:3539-52. 2002
    ..Collectively, these results suggest that members of the GTP-binding Era/Obg family are important proteins with precise, yet still not fully understood, roles in bacterial growth and viability...
  89. ncbi Secretion of protease nexin-1 by C6 glioma cells is under the control of a heterotrimeric G protein, Go1
    A Lagriffoul
    CNRS UPR 9023, Centre CNRS INSERM de Pharmacologie et Endocrinologie, 141 rue de la Cardonille, F 34094 Montpellier Cedex 5, France
    J Biol Chem 271:31508-16. 1996
    ..These results indicate, that in C6 glioma cells, PN-1 secretion could be regulated by both Go1alpha expression and activation...
  90. pmc Balance of Irgm protein activities determines IFN-gamma-induced host defense
    Stanley C Henry
    Geriatric Research, Education, and Clinical Center, VA Medical Center, Durham, NC 27705, USA
    J Leukoc Biol 85:877-85. 2009
    ....
  91. pmc Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein
    J Pavlovic
    Institut für Immunologie und Virologie, Universitat Zurich, Switzerland
    J Virol 64:3370-5. 1990
    ....
  92. ncbi Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor
    J F Maddox
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:6972-8. 1997
    ..Moreover, they provide additional evidence that the LXA4 stable analogs retain selective bioactivity in monocytes and are valuable instruments for examining the functions and modes of action of LXA4...
  93. ncbi Cloning and characterization of a novel cDNA that is IFN-gamma-induced in mouse peritoneal macrophages and encodes a putative GTP-binding protein
    W P Lafuse
    Department of Medical Microbiology and Immunology, Ohio State University, Columbus 43210
    J Leukoc Biol 57:477-83. 1995
    ..IRG-47 encodes an intracellular protein that contains three conserved protein motifs present in GTP-binding proteins. Analysis of the protein sequence of Mg21 showed that these three conserved protein motifs are also present in Mg21...
  94. ncbi Transglutaminase 2 in the balance of cell death and survival
    Laszlo Fesus
    Department of Biochemistry and Molecular Biology, Faculty of Medicine and Signaling and Apoptosis Research Group of the Hungarian Academy of Sciences, Research Center for Molecular Medicine, University of Debrecen, Debrecen, Hungary
    FEBS Lett 579:3297-302. 2005
    ..This function of TG2 is partially achieved by being expressed and activated also in macrophages digesting apoptotic cells and mediating a crosstalk between dying and phagocytic cells...
  95. ncbi Interferon-induced Mx proteins in antiviral host defense
    Otto Haller
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    Biochimie 89:812-8. 2007
    ..As a consequence, these viral components are trapped and sorted to locations where they become unavailable for the generation of new virus particles...
  96. ncbi Tissue transglutaminase in normal and abnormal wound healing: review article
    E A M Verderio
    School of Science, Nottingham Trent University, Nottingham, United Kingdom
    Amino Acids 26:387-404. 2004
    ....
  97. ncbi What is the role of beta-adrenergic signaling in heart failure?
    Martin J Lohse
    Institute of Pharmacology, Versbacher Strasse 9, 97078 Wuerzburg, Germany
    Circ Res 93:896-906. 2003
    ..Newer experimental therapeutic strategies aim at the receptor desensitization machinery and at downstream signaling steps...
  98. pmc Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function
    T Galvez
    , CNRS-UPR9023, CCIPE, 141 rue de la Cardonille, F-34094 Montpellier, France
    EMBO J 20:2152-9. 2001
    ..These data indicate that multiple allosteric interactions between the two subunits are required for wild-type functioning of the GABA(B) receptor and highlight further the importance of the dimerization process in GPCR activation...
  99. pmc Guanylate-binding protein-1 expression is selectively induced by inflammatory cytokines and is an activation marker of endothelial cells during inflammatory diseases
    Clara Lubeseder-Martellato
    Department of Virus Induced Vasculopathy, Institute of Molecular Virology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Am J Pathol 161:1749-59. 2002
    ..These results indicate that GBP-1 is a novel cellular activation marker that characterizes the IC-activated phenotype of endothelial cells...
  100. ncbi The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B
    S Bour
    Laboratory of Molecular Microbiology, NIAID, National Institutes of Health, Bethesda, Maryland 20892 0460, USA
    J Biol Chem 276:15920-8. 2001
    ..However, in the presence of Vpu, this HIV-mediated NF-kappaB activation was markedly reduced. These results suggest that Vpu modulates both virus- and cytokine-induced activation of NF-kappaB in HIV-1-infected cells...
  101. ncbi A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains
    P Chardin
    Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, Valbonne, France
    Nature 384:481-4. 1996
    ..We propose that other proteins with a Sec7 domain regulate different members of the ARF family...

Research Grants62

  1. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    ....
  2. Human Platelet Defects in Transcription Factor RUNX1 Haplodeficiency
    ANGARA KONETI RAO; Fiscal Year: 2013
    ..They will advance our understanding of the mechanisms in normal and abnormal platelet function. ..
  3. Dissecting the role of one neuronal RhoGEF amongst many: the Kalirin-7 null mouse
    Richard E Mains; Fiscal Year: 2012
    ..Kalirin-7, an activator of small GTP binding proteins of the Rho family, is localized to dendritic spines and is one of a small number of factors known to be ..
  4. Sex Differences in Stress Receptors Underlie Female Vulnerability to Stress
    Debra A Bangasser; Fiscal Year: 2012
    ..This project will not only help us understand why women are more vulnerable to stress-related mental illnesses, but it will identify new pharmaceutical targets which can lead to treatments that are efficacious in both men and women. ..
  5. Plexin signalling in melanocyte biology and melanoma progression
    Glynis A Scott; Fiscal Year: 2013
    ..migration and dendrite formation through stimulation of intracellular signaling pathways that include the GTP binding proteins Ras, Rho, Rac, integrins and LIM kinase- cofilin pathways...
  6. Regulation of Neuronal Survival by the Rit GTPase
    DOUGLAS ALLEN ANDRES; Fiscal Year: 2012
    ..Thus, the goal of this research is to speed progress toward therapeutic exploitation of this protein in neurodegenerative disease. ..
  7. Sex Differences in Stress Receptors Underlie Female Vulnerability to Stress
    Debra A Bangasser; Fiscal Year: 2013
    ..Moreover, because CRF antagonists are being developed to treat these illnesses, considering sex differences in CRF receptors may increase the efficacy of these compounds in women. ..
  8. Regulation of Rho Signaling by S-Nitrosothiols
    A Richard Whorton; Fiscal Year: 2012
    Small GTP binding proteins of the ras superfamily are recognized to play a key role in development of cardiovascular disease. In this regard Rho proteins are particularly important...
  9. Coordinate Regulation Of Nuclear DGK-theta and PLD
    DANIEL RABEN; Fiscal Year: 2009
    ..We believe that an understanding of nuclear lipid signaling is key to our ability to intervene in events such as wound repair and tissue remodeling. ..
  10. CELL BIOLOGY OF BIOACTIVE PEPTIDE SECRETION
    Richard E Mains; Fiscal Year: 2013
    ..Our focus on PAM led to the discovery of Kalirin, a GDP/GTP exchange factor (GEF) for small GTP binding proteins of the Rho family, that interacts with the cytosolic domain of PAM...
  11. MOLECULAR STUDIES OF RETINAL DEGENERATION IN DROSOPHILA
    Nansi J Colley; Fiscal Year: 2013
    ..We anticipate that this work will greatly impact our understanding of the fundamental mechanisms of protein trafficking and also provide important insights into retinal diseases such as RP and AMD. ..
  12. Asbestosis is regulated by Rac1-mediated mitochondrial H2O2 levels
    A Brent Carter; Fiscal Year: 2013
    ....
  13. RhoH GTPase in Hematopoiesis and Cancer
    David A Williams; Fiscal Year: 2013
    ..abstract_text> ..
  14. Regulation of the mTOR Pathway By Nutrients
    David M Sabatini; Fiscal Year: 2013
    ..Furthermore, some of the signaling mechanisms we uncover may serve in the future as targets for drug development. ..
  15. SMALL GTP BINDING PROTEINS IN GASTROINTESTINAL MUCOSA
    JAMES RICHARD GOLDENRING; Fiscal Year: 2013
    ..These investigations will establish how disruption of vesicle trafficking processes that regulate the establishment and maintenance of intestinal epithelial cell polarity may lead to carcinogenesis. ! ..
  16. Inorganic phosphate regulated proliferation, transformation and tumorigenesis
    George R Beck; Fiscal Year: 2013
    ..This proposal will investigate the role of dietary inorganic phosphate in cancer initiation, promotion and progression. ..
  17. FASEB SRC on Regulation and Function of Small GTPases
    KAREN M CICHOWSKI; Fiscal Year: 2013
    ..While this meeting has always had an inclusive atmosphere we will also be offering 8 travel awards to minority and female applicants at various stages of their careers. This initiative will be detailed in the application. ! ..
  18. The Role of FKBP38 in tumorigenesis associated with Tsc deficiency
    Yu Jiang; Fiscal Year: 2012
    ..Successful completion of this study would allow us to identify potential therapeutic target for intervention of the tuberous sclerosis complex and cancer. ..
  19. CALCIUM AND PANCREATIC STIMULUS-SECRETION COUPLING
    John A Williams; Fiscal Year: 2013
    ..Using a proteomics discovery strategy, we have identified a number of small GTP binding proteins on the zymogen granule including RabSD, Rab6, Rab11, Rab27B and Rap1...
  20. The Role of RhoA in the Molecular Pathogenesis of Heart Disease
    MARIA IRENE KONTARIDIS; Fiscal Year: 2013
    ....
  21. Rab proteins and alpha-Synuclein toxicity in Neurodegenerative Disease
    NIKOLAUS RENZ MCFARLAND; Fiscal Year: 2013
    ..Developing these research skills, along with my continued clinical training and experience are critical to becoming a successful, independent clinician-scientist committed to translational neuroscience. ..
  22. PTSD-like phenotype of mice lacking GIT2
    Richard T Premont; Fiscal Year: 2011
    ..A deeper understanding of how GIT2 functions to regulate anxiety and the extinction of fear may provide insights into human fear and anxiety disorders such as PTSD. ..
  23. Ras and Phosphoinositide 3-kinase Signaling in Lens Development
    Lixing W Reneker; Fiscal Year: 2012
    ..This knowledge will help to develop new methods to prevent and treat posterior capsular opacification (PCO), the most common complication of cataract surgery. ..
  24. BIOPHYSICS OF RECEPTOR/G-PROTEIN INTERACTIONS
    Oleg G Kisselev; Fiscal Year: 2011
    ....
  25. Inactivation of hyperpermeability after ischemia-reperfusion induced inflammation
    Walter N Duran; Fiscal Year: 2012
    ..Our results should be of clinical relevance to revascularization in elective and emergency vascular surgery. ..
  26. Regulation of endothelial permeability in sepsis
    Michelle L Matter; Fiscal Year: 2013
    ..This study will test whether this RRas is a therapeutic target in preclinical mouse models of sepsis. .! ..
  27. Molecular Mechanisms Controlling Endocytic Recycling
    STEVEN H CAPLAN; Fiscal Year: 2013
    ..Among the key endocytic regulatory proteins are more than 50 Rab-GTP binding proteins and their effectors that control vesicle transport and fusion events...
  28. Genomic and Functional Dissection of GTPase-Mutant Melanoma
    CHELSEA SCHWARTZ PLACE; Fiscal Year: 2013
    ..In particular, the importance of GTP binding proteins that undergo oncogenic mutations has been increasingly recognized...
  29. Septin Filaments: Architecture, Assembly and Regulation
    Jeremy W Thorner; Fiscal Year: 2013
    ..Understanding how septin assembly is regulated in this model eukaryotic organism may offer new insights about how aberrant septin structures contribute to malignancy and disease. ..
  30. The role of tissue transglutaminase in cancer cell migration
    LINDSEY BOROUGHS; Fiscal Year: 2012
    ..abstract_text> ..
  31. PLATELET SUFACE ACTIVATION IN HEMOSTASIS AND THROMBOSIS
    SANFORD SHATTIL; Fiscal Year: 1993
    ..Overall, these studies should lead to a more detailed understanding of the platelet membrane events required for normal hemostasis and the role of membrane activation in hemorrhagic and thrombotic disorders...
  32. CONTROL OF MICROCIRCULATORY EXCHANGE FUNCTION
    Walter N Duran; Fiscal Year: 2012
    ..We will apply intravital microscopy in conjunction with computer-assisted image analysis and molecular biology approaches to elucidate the postulated mechanisms. ..
  33. TRANSMEMBRANE SIGNALLING IN GENETIC OBESITY
    Kathryn LaNoue; Fiscal Year: 1993
    ..Adenosine receptors or the GTP binding proteins, which act as transducers for these receptors, may be important in normal regulation of lipid storage and ..
  34. HETEROTRIMERIC G PROTEINS AND EXOCYTOSIS
    BHANU JENA; Fiscal Year: 1999
    ..Understanding the role of the secretory granule membrane-associated G-proteins in exocytosis will help us understand better this fundamental cellular process which when impaired leads to a number of diseases. ..
  35. Sympathetic Control in Heart Failure: A Role of Statins
    Irving H Zucker; Fiscal Year: 2010
    ..We will determine if a class of drugs called statins has the potential for reducing some of the deleterious consequences of compensatory mechanisms in the heart failure state. ..
  36. SIGNAL TRANSDUCTION IN T CELLS
    CONSTANTINE TSOUKAS; Fiscal Year: 1991
    The purpose of this proposal is to investigate the role of GTP binding proteins in human T cell activitation...
  37. REGULATION OF PHOSPHOLIPASE C
    JOHN E SONDEK; Fiscal Year: 2013
    ..The mechanism whereby this occurs is unknown, and the goal of Specific Aim 2 will be to determine the structure of a PLC-b isozyme bound to Gbg. ..
  38. NOVEL N-PROTEIN COUPLES TRH RECEPTOR TO PHOSPHOLIPASE C
    THOMAS COTE; Fiscal Year: 1990
    ....
  39. ARF PROTEINS IN CELLULAR REGULATION OF PHOSPHOLIPASE D
    Guillermo Romero; Fiscal Year: 2000
    ....
  40. GTP-BINDING PROTEIN RHO IN T CELL SIGNALING PATHWAYS
    Jonathan Moorman; Fiscal Year: 2000
    ..Advocates within the Beirne Carter Center for Immunology and the Departments of Medicine and Microbiology will insure that I receive excellent training as I make the transition to an independent investigator. ..
  41. ONCOGENIC RAS REQUIRES NFKB ANTIAPOPTOTIC FUNCTION
    MARTY MAYO; Fiscal Year: 2003
    ..These studies will elucidate the mechanisms by which NF kappa B provides protection against apoptosis in response to oncogenic Ras and will potentially provide new insight into the development of anticancer therapies. ..
  42. IL-1 AND B-ADRENERGIC SYSTEM OF HUMAN AIRWAY EPITHELIUM
    Steven Kelsen; Fiscal Year: 1999
    ..g. betaAR, GTP binding proteins, adenylyl cyclase) is poorly understood...
  43. Characterization of the Vibrio harveyi CgtA protein
    Janine Maddock; Fiscal Year: 2004
    ..Since there is a strong similarity between CgtA-like proteins in diverse organisms, including humans, we believe that studies planned by us and described is this application are of general biological significance. ..
  44. Characterization of a novel nuclear Rab protein
    Ying Huang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  45. APPLICATION OF PHOTOAFFINITY NUCLEOTIDE ANALOGS
    Boyd Haley; Fiscal Year: 1999
    ..ARF is a GTP binding protein that activates some bacterial toxins which use NAD+ to ADPribosylate other GTP binding proteins. Using [32P]8N3GTP and [32P]2N3NAD+ data has been obtained which shows that ARF alone contains both GTP and ..
  46. NMR studies of the structure of myristylated Arf6
    Dawit Gizachew; Fiscal Year: 2006
    b>GTP binding proteins (GTPases, G proteins) mediate a large number of important cellular processes...
  47. PROTEIN IMPORT INTO MITOCHONDRIA
    Debkumar Pain; Fiscal Year: 2002
    ..There is strong evidence that the constituents of mitochondrial translocases and their role in protein import are conserved between yeast and humans. ..
  48. ANALYSIS OF E COLI GTP-BINDING PROTEINS AND THEIR GENES
    PAUL MARCH; Fiscal Year: 1993
    ..In addition, mutational studies similar to those proposed above will be employed to elucidate amino acid residues required by Ribonuclease III to recognize and cleave double stranded RNA...
  49. Assay for HTS of Gi/Go-linked GPCRs: mGluR7 as Prot(RMI)
    COLLEEN NISWENDER; Fiscal Year: 2007
    Abstract Pharmacological agents targeting receptors coupled to GTP binding proteins represent promising clinical agents spanning a multitude of human diseases...
  50. GTP BINDING PROTEINS AND INSULIN RECEPTOR SINGNALING
    CHIN SUNG; Fiscal Year: 1999
    ..via its two SH2 and one SH3 domains, serves as an adaptor molecule to directly link the activated IR to GTP binding proteins. First, the investigators will study the Ras pathway...
  51. GTP BINDING PROTEINS IN MITOCHONDRIAL PROTEIN IMPORT
    RONALD PAYNE; Fiscal Year: 2001
    ..Identifying the components of this ribosome-mitochondrial interaction, and the function of these novel G-proteins, is crucial to understanding how mitochondria grow, divide, and repair themselves. ..
  52. STRUCTURE AND FUNCTIONS OF G-PROTEIN BETA-GAMMA SUBUNITS
    John Northup; Fiscal Year: 1990
    ..This set of studies should allow for the evaluation, quantitatively and qualitatively, of existing hypotheses concerning the cellular function of the beta gamma subunits of signal transducing G-proteins...
  53. BIOCHEMICAL AND GENETIC ANALYSIS OF CGTA IN CAULOBACTER
    Janine Maddock; Fiscal Year: 2002
    ..From these studies, they will be able to suggest a role for this subfamily of GTPases and will develop tools which may be helpful for the identification of regulators and downstream effector proteins in other organisms. ..
  54. Molecular Signals Against Beta-AR-Stimulated Apoptosis
    Krishna Singh; Fiscal Year: 2005
    ..These studies will advance our understanding of the signaling pathways activated by stimulation of beta-AR and Beta1 integrin, and their role in the regulation of cardiac myocyte apoptosis and myocardial remodeling. ..
  55. Role of Rac in LTP and Hippocampus-dependent Memory
    MARIA TEJADA SIMON; Fiscal Year: 2009
    ....
  56. STRUCTURE AND REGULATION OF CDC42HS
    Robert Oswald; Fiscal Year: 2001
    DESCRIPTION: A large number of key biological signaling processes are mediated and regulated via GTP binding proteins. Members of this superfamily of proteins serve as biological switches, turning biological signaling processes on or off ..
  57. MOLECULAR MECHANISMS/BETA CELL DYSFUNCTION IN DIABETES
    GRAEME BELL; Fiscal Year: 2002
    ....
  58. INSULIN SIGNALING THROUGH GTP BINDING PROTEINS
    Jeffrey Pessin; Fiscal Year: 2003
    ..abstract_text> ..
  59. FASEB CONFERENCE--RAS SUPERFAMILY OF PROTEINS
    Alan Hall; Fiscal Year: 1993
    ....
  60. MOLECULAR MECHANISMS OF NEURONAL MORPHOGENESIS
    Liqun Luo; Fiscal Year: 2004
    ....
  61. 1992 ASBMB FALL SYMPOSIA
    Philip Stahl; Fiscal Year: 1992
    ....
  62. Novel Insulin Signals Regulating GLUT4 Translocation
    Jeffrey Pessin; Fiscal Year: 2005
    ....