calcium binding proteins

Summary

Summary: Proteins to which calcium ions are bound. They can act as transport proteins, regulator proteins, or activator proteins. They typically contain EF HAND MOTIFS.

Top Publications

  1. ncbi Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 430:213-8. 2004
  2. ncbi Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Immunol 7:576-82. 2006
  3. ncbi Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
    G Luo
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 386:78-81. 1997
  4. pmc Calreticulin: one protein, one gene, many functions
    M Michalak
    MRC Group in Molecular Biology of Membranes, Department of Biochemistry, University of Alberta, 3 56 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7
    Biochem J 344:281-92. 1999
  5. ncbi Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding
    Robert D Fisher
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Cell 128:841-52. 2007
  6. ncbi Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf
    Amal Amer
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:35217-23. 2006
  7. pmc Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis
    Eiji Morita
    Department of Biochemistry, University of Utah, Salt Lake City, UT 84132 3201, USA
    EMBO J 26:4215-27. 2007
  8. ncbi Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis
    H Chen
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 394:793-7. 1998
  9. ncbi The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint
    Anna De Antoni
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Curr Biol 15:214-25. 2005
  10. ncbi Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains
    M Yamabhai
    Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
    J Biol Chem 273:31401-7. 1998

Detail Information

Publications387 found, 100 shown here

  1. ncbi Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    Sanjeev Mariathasan
    Molecular Oncology Department, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 430:213-8. 2004
    ..Notably, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways...
  2. ncbi Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
    Luigi Franchi
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Immunol 7:576-82. 2006
    ..Thus, detection of flagellin through Ipaf induces caspase-1 activation independently of Toll-like receptor 5 in salmonella-infected and lipopolysaccharide-tolerized macrophages...
  3. ncbi Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
    G Luo
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 386:78-81. 1997
    ..These results indicate that ECM calcification must be actively inhibited in soft tissues. To our knowledge, Mgp is the first inhibitor of calcification of arteries and cartilage to be characterized in vivo...
  4. pmc Calreticulin: one protein, one gene, many functions
    M Michalak
    MRC Group in Molecular Biology of Membranes, Department of Biochemistry, University of Alberta, 3 56 Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7
    Biochem J 344:281-92. 1999
    ..Studies on the cell biology of calreticulin revealed that the ER membrane is a very dynamic intracellular compartment affecting many aspects of cell physiology...
  5. ncbi Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding
    Robert D Fisher
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Cell 128:841-52. 2007
    ..ALIX therefore serves as a flexible, extended scaffold that connects retroviral Gag proteins to ESCRT-III and other cellular-budding machinery...
  6. ncbi Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf
    Amal Amer
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:35217-23. 2006
    ..These results reveal that Ipaf restricts Legionella replication through the regulation of phagosome maturation, providing a novel function for NLR proteins in host defense against an intracellular bacterium...
  7. pmc Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis
    Eiji Morita
    Department of Biochemistry, University of Utah, Salt Lake City, UT 84132 3201, USA
    EMBO J 26:4215-27. 2007
    ..These experiments suggest that the ESCRT pathway may be recruited to facilitate analogous membrane fission events during HIV budding, MVB vesicle formation, and the abscission stage of cytokinesis...
  8. ncbi Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis
    H Chen
    Howard Hughes Medical Institute and Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 394:793-7. 1998
    ..We propose that epsin may participate, together with Eps15, in the molecular rearrangement of the clathrin coats that are required for coated-pit invagination and vesicle fission...
  9. ncbi The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint
    Anna De Antoni
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Curr Biol 15:214-25. 2005
    ..These events are linked to the existence of two distinct conformers of Mad2: a closed conformer bound to its kinetochore receptor Mad1 or its target in the checkpoint Cdc20 and an open conformer unbound to these ligands...
  10. ncbi Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains
    M Yamabhai
    Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706 1532, USA
    J Biol Chem 273:31401-7. 1998
    ..We propose that Intersectin is a component of the endocytic machinery...
  11. pmc Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint
    Daniela A Brito
    Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, New York 12222, USA
    Curr Biol 16:1194-200. 2006
    ..Thus, vertebrate cells do not adapt to the SAC. Rather, our data suggest that in normal cells, the SAC cannot prevent a slow but continuous degradation of cyclin B that ultimately drives the cell out of mitosis...
  12. ncbi Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
    Y Xue
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Hum Mol Genet 8:723-30. 1999
    ..These results establish the phenotype of Cm /+ mice as a contiguous gene deletion syndrome and demonstrate that Jag1 is essential for remodeling of the embryonic vasculature...
  13. pmc Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
    Claire Ditchfield
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Rd, Manchester M13 9PT, UK
    J Cell Biol 161:267-80. 2003
    ..Together, these results suggest that by targeting checkpoint proteins to kinetochores, Aurora B couples chromosome alignment with anaphase onset...
  14. ncbi High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    Michael Reedijk
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer Res 65:8530-7. 2005
    ....
  15. ncbi Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
    Derk Amsen
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 117:515-26. 2004
    ..Notch directs Th2 differentiation by inducing GATA3 and by directly regulating il4 gene transcription through RBPJkappa sites in a 3' enhancer...
  16. pmc The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15
    A S Sengar
    Programs of Cancer and Blood Research, and Developmental Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    EMBO J 18:1159-71. 1999
    ..The Ese1-Eps15 scaffold therefore links dynamin, epsin and other endocytic pathway components...
  17. ncbi Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection
    Regine Gläser
    Clinical Research Unit of the Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Nat Immunol 6:57-64. 2005
    ..Zn(2+)-saturated psoriasin showed diminished antimicrobial activity, suggesting that Zn(2+) sequestration could be a possible antimicrobial mechanism. Thus, psoriasin may be key to the resistance of skin against E. coli...
  18. ncbi Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
    Qinghua Zeng
    Laboratory of Molecular Signaling and Apoptosis, Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 8:13-23. 2005
    ..Our results elucidate a novel mechanism by which the direct interplay between tumor cells and ECs promotes angiogenesis through MAPK and Notch signaling pathways...
  19. ncbi Synaptotagmin I functions as a calcium regulator of release probability
    R Fernandez-Chacon
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas 75390 9111, USA
    Nature 410:41-9. 2001
    ..Therefore, Ca2+ binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse...
  20. ncbi The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
    B Conradt
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 93:519-29. 1998
    ..We propose that EGL-1 activates programmed cell death by binding to and directly inhibiting the activity of CED-9, perhaps by releasing the cell death activator CED-4 from a CED-9/CED-4-containing protein complex...
  21. ncbi Notch signalling pathway mediates hair cell development in mammalian cochlea
    P J Lanford
    Department of Cell Biology, Georgetown University School of Medicine, Washington, DC 20007, USA
    Nat Genet 21:289-92. 1999
    ..These results provide direct evidence for Notch-mediated lateral inhibition in a mammalian system and support a role for Notch in the development of the cochlear mosaic...
  22. ncbi Switching of Ca2+-dependent inactivation of Ca(v)1.3 channels by calcium binding proteins of auditory hair cells
    Philemon S Yang
    Ca2 Signals Laboratory, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 26:10677-89. 2006
    ..In particular, the rare subtype CaBP4 is specific to IHCs, and CaBP4 proves capable of eliminating even the potent baseline CDI of Ca(V)1.3. CaBP4 thereby represents a plausible candidate for moderating CDI within IHCs...
  23. pmc Potent rescue of human immunodeficiency virus type 1 late domain mutants by ALIX/AIP1 depends on its CHMP4 binding site
    Yoshiko Usami
    Program in Gene Function and Expression, University of Massachusetts Medical School, LRB 526, 364 Plantation Street, Worcester, MA 01605, USA
    J Virol 81:6614-22. 2007
    ..Our data establish that ALIX can have a dramatic effect on HIV-1 release and suggest that the ability to use ALIX may allow HIV-1 to replicate in cells that express only low levels of Tsg101...
  24. ncbi Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 124:3241-51. 1997
    ..Thus the combined effects of Notch and its target genes cut and wingless regulate the expression of Notch ligands which restrict Notch activity to the dorsoventral boundary...
  25. pmc The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint
    E Weiss
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder 80309 0347, USA
    J Cell Biol 132:111-23. 1996
    ..We propose that the essential MPS1 protein kinase functions both in SPB duplication and in a mitotic checkpoint monitoring spindle integrity...
  26. pmc Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint
    Lucia Sironi
    Structural Biology Unit, Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    EMBO J 21:2496-506. 2002
    ..We also show that unlocking the Mad2 C-terminal tail is required for ligand release from Mad2, and that the 'safety belt' mechanism may prolong the lifetime of Mad2-ligand complexes...
  27. pmc Calreticulin
    M Michalak
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Biochem J 285:681-92. 1992
  28. pmc Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release
    Jez G Carlton
    Department of Infectious Diseases, King s College London School of Medicine, London SE1 9RT, United Kingdom
    Proc Natl Acad Sci U S A 105:10541-6. 2008
    ..Last, we demonstrate that overexpression of Chmp4b and Chmp4c differentially inhibits HIV-1 release and cytokinesis, suggesting possible reasons for gene expansion within the mammalian Class E VPS pathway...
  29. ncbi Mutations in the human Jagged1 gene are responsible for Alagille syndrome
    T Oda
    Laboratory of Gene Transfer, National Human Genome Research Institutes of Health, Bethesda, Maryland 20892 4442, USA
    Nat Genet 16:235-42. 1997
    ..We conclude that AGS is caused by haploinsufficiency of JAG1...
  30. ncbi Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves
    P A Price
    Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
    Arterioscler Thromb Vasc Biol 18:1400-7. 1998
    ..The results indicate that the improved warfarin plus vitamin K treatment protocol developed in this study should provide a useful model to investigate the role of MGP in preventing calcification of arteries and heart valves...
  31. pmc Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins
    Juan Martin-Serrano
    Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:12414-9. 2003
    ....
  32. pmc Structural basis for viral late-domain binding to Alix
    Sangho Lee
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health NIH, US Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Struct Mol Biol 14:194-9. 2007
    ..Overexpression of the V domain inhibits HIV-1 release from cells. This inhibition of release is reversed by mutations that block binding of the Alix V domain to p6...
  33. pmc Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression
    Michela Noseda
    Department of Medical Biophysics, Vancouver, British Columbia, Canada V5Z 1L3
    Mol Cell Biol 24:8813-22. 2004
    ..We suggest that Notch activation contributes to contact inhibition of endothelial cells, in part through repression of p21Cip1 expression...
  34. ncbi EH and UIM: endocytosis and more
    Simona Polo
    Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milan, Italy
    Sci STKE 2003:re17. 2003
    ..The focus of this review is to integrate available knowledge of the EH- and mUb networks with predictions of genetic and physical interactions stemming from functional genomics approaches...
  35. pmc Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction
    Jörg van den Boom
    Department of Neuropathology, Heinrich Heine University, Moorenstrasse 5, D 40225 Dusseldorf, Germany
    Am J Pathol 163:1033-43. 2003
    ..Thus, we identified and validated a set of interesting candidate genes whose differential expression likely plays a role in astrocytoma progression...
  36. pmc Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication
    Sam Li
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, England, UK
    J Cell Biol 173:867-77. 2006
    ..This suggests a model for SPB duplication where the half-bridge doubles in length by association of the Sfi1p C termini, thereby providing a new Sfi1p N terminus to initiate SPB assembly...
  37. ncbi Low concentrations of taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy
    Amy E Ikui
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cell Cycle 4:1385-8. 2005
    ..The induction of apoptosis and aneuploidy by low concentrations of Taxol may result from chromosome missegregation caused by spindle checkpoint defects...
  38. ncbi Membrane fusion
    Reinhard Jahn
    Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Cell 112:519-33. 2003
    ..Cellular fusion machines are adapted to fit the needs of different reactions but operate by similar principles in order to achieve merging of the bilayers...
  39. ncbi S100A7, S100A10, and S100A11 are transglutaminase substrates
    M Ruse
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, Ohio 44106 4970, USA
    Biochemistry 40:3167-73. 2001
    S100 proteins are a family of 10-14 kDa EF-hand-containing calcium binding proteins that function to transmit calcium-dependent cell regulatory signals...
  40. ncbi Adult-onset type II citrullinemia and idiopathic neonatal hepatitis caused by citrin deficiency: involvement of the aspartate glutamate carrier for urea synthesis and maintenance of the urea cycle
    Takeyori Saheki
    Department of Molecular Metabolism and Biochemical Genetics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Mol Genet Metab 81:S20-6. 2004
    ....
  41. ncbi The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20
    Xuelian Luo
    Department of Biochemistry, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 9:59-71. 2002
    ..Our data suggest that, upon checkpoint activation, Mad1 recruits Mad2 to unattached kinetochores and may promote binding of Mad2 to Cdc20...
  42. ncbi The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases
    Kunhua Song
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    Cell 125:453-66. 2006
    ..These findings reveal a transcriptional regulatory mechanism that modulates cardiac growth and gene expression by linking hypertrophic signals to the cardiac genome...
  43. ncbi Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells
    Laura S Harrington
    Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK
    Microvasc Res 75:144-54. 2008
    ..The regulation of sVEGFR1 provides a novel mechanism for Dll4 signalling to regulate cells at distance, not just in adjacent cells...
  44. ncbi Role of calcium binding proteins in the control of cerebellar granule cell neuronal excitability: experimental and modeling studies
    D Gall
    Laboratoire de Neurophysiologie CP601, Faculte de Medecine, Universite Libre de Bruxelles, Route de Lennik 808, B 1070 Brussels, Belgium
    Prog Brain Res 148:321-8. 2005
    b>Calcium binding proteins, such as calretinin, are abundantly expressed in distinctive patterns in the central nervous system but their physiological function remains poorly understood...
  45. ncbi Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic reticulum membrane
    L Zhang
    Department of Medicine and the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 272:23389-97. 1997
    ..Taken together, these results suggest that junctin, calsequestrin, triadin, and the ryanodine receptor form a quaternary complex that may be required for normal operation of Ca2+ release...
  46. ncbi Quantitative analysis of neuronal diversity in the mouse olfactory bulb
    S Parrish-Aungst
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Comp Neurol 501:825-36. 2007
    ..These data suggest that the chemospecific populations of neurons in glomeruli form distinct subpopulations and that GAD isoforms are preferentially regulated in different neurochemical cell types...
  47. ncbi Reversible translocation and activity-dependent localization of the calcium-myristoyl switch protein VILIP-1 to different membrane compartments in living hippocampal neurons
    Christina Spilker
    Neuroscience Research Center Institute for Physiology of the Charite, Humboldt University Berlin, Signal Transduction Research Group, D 10117 Berlin, Germany
    J Neurosci 22:7331-9. 2002
    ....
  48. pmc Clathrin- and caveolin-1-independent endocytosis: entry of simian virus 40 into cells devoid of caveolae
    Eva Maria Damm
    Institute of Biochemistry, Swiss Federal Institute of Technology Zurich ETHZ, CH 8093 Zurich, Switzerland
    J Cell Biol 168:477-88. 2005
    ..Our results revealed the existence of a virus-activated endocytic pathway from the plasma membrane to the ER that involves neither clathrin nor caveolae and that can be activated also in the presence of cav-1...
  49. ncbi SERRATE is a novel nuclear regulator in primary microRNA processing in Arabidopsis
    Li Yang
    National Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Plant J 47:841-50. 2006
    ..Our data strongly suggest that SE plays an important and general role in pri-miRNA processing, and it would be interesting to determine whether animal SE homologues may play similar roles in vivo...
  50. ncbi Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta regulate IgE receptor-triggered exocytosis in cultured mast cells
    Yaara Kapp-Barnea
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Immunol 171:5320-7. 2003
    ..We conclude that NCS-1 is involved in the control of regulated exocytosis in nonneural cells, where it contributes to stimulus-secretion coupling by interacting with PI4Kbeta and positive regulation of its activity...
  51. pmc The many facets of Notch ligands
    B D'Souza
    Department of Biological Chemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1737, USA
    Oncogene 27:5148-67. 2008
    ..Oncogene (2008) 27, 5148-5167; doi:10.1038/onc.2008.229...
  52. ncbi Centrin-2 is required for centriole duplication in mammalian cells
    Jeffrey L Salisbury
    Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA
    Curr Biol 12:1287-92. 2002
    ..However, aside from their role as an anchor point for pericentriolar material and as basal bodies of flagella and cilia, the functional attributes of centrioles remain enigmatic...
  53. ncbi NAIP and Ipaf control Legionella pneumophila replication in human cells
    Maya Vinzing
    Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Immunol 180:6808-15. 2008
    ..In conclusion, hNAIP and hIpaf mediate innate intracellular defense against flagellated Legionella in human cells...
  54. pmc Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II
    J R Marszalek
    Division of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA
    Proc Natl Acad Sci U S A 96:5043-8. 1999
    ....
  55. ncbi Downregulation of several fibulin genes in prostate cancer
    Agnes Wlazlinski
    Department of Urology, Heinrich Heine University, Duesseldorf, Germany
    Prostate 67:1770-80. 2007
    ..Fibulins, encoded by FBLN genes, are extracellular matrix proteins influencing cell adhesion and migration. Altered expression of fibulins is associated with progression of several cancer types, but has not been studied in prostate cancer...
  56. pmc Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5
    T M Kapoor
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 150:975-88. 2000
    ..Monastrol is thus a useful tool to study mitotic processes, detection and correction of chromosome malorientation, and contributions of Eg5 to spindle assembly and maintenance...
  57. pmc Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I
    T Voets
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 98:11680-5. 2001
    ..Alternatively, synaptotagmin I could function as calcium sensor for the readily releasable pool, leading to the destabilization of the pool in its absence...
  58. pmc Notch signalling via RBP-J promotes myeloid differentiation
    T Schroeder
    GSF, National Research Centre for Environment and Health, Institute for Clinical Molecular Biology, Marchioninistrabetae 25, D 81377 Munich, Germany
    EMBO J 19:2558-68. 2000
    ..Similar to the induction of mN1(IC), Jagged1 accelerated granulocytic differentiation of 32D cells. Taken together, our data suggest that activation of mNotch1 promotes myeloid differentiation via RBP-J transactivation...
  59. ncbi Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall
    H M Spronk
    Department of Biochemistry, Maastricht University, Maastricht, The Netherlands
    Biochem Biophys Res Commun 289:485-90. 2001
    ..Our data demonstrate the close association between MGP and calcification. It is suggested that undercarboxylated MGP is biologically inactive and that poor vascular vitamin K status may form a risk factor for vascular calcification...
  60. ncbi Binding of mouse and human fibulin-2 to extracellular matrix ligands
    T Sasaki
    Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    J Mol Biol 254:892-9. 1995
    ..This indicated multifunctional binding properties for fibulin-2 and several alternative routes for its integration into basement membranes and other extracellular structures...
  61. ncbi Modulation of endothelial cell adhesion by hevin, an acidic protein associated with high endothelial venules
    J P Girard
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 271:4511-7. 1996
    ..Hevin-treated cells do not form focal adhesions and exhibit a rounded morphology. Together, these results suggest that hevin is an abundant extracellular protein that modulates high endothelial cell adhesion to the basement membrane...
  62. ncbi Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome
    T Fujita
    Department of Molecular Biology, Tokyo Metropolitan Institute of Gerontology, Japan
    Biochim Biophys Acta 1263:249-52. 1995
    ..3-q11.2 segment of the X chromosome. This gene thus could be a candidate for one of the X-linked diseases mapped to this regions...
  63. pmc Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2
    V Sudakin
    Institute for Cancer Research, The Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Cell Biol 154:925-36. 2001
    ..We propose that the preformed interphase pool of MCC allows for rapid inhibition of APC/C when cells enter mitosis. Unattached kinetochores then target the APC/C for sustained inhibition by the MCC...
  64. ncbi Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans
    M Gomez
    Department of Central Nervous System, F Hoffmann La Roche, 4070, Basel, Switzerland
    Neuron 30:241-8. 2001
    ..Thus, proper calcium signaling via NCS-1 defines a novel pathway essential for associative learning and memory...
  65. ncbi The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster
    R J Fleming
    Howard Hughes Medical Institute, Department of Cell Biology, Yale University, New Haven, Connecticut 06511
    Genes Dev 4:2188-201. 1990
    ..Finally, we discuss the implications of Serrate function within the context of other cell-surface molecules known to be involved in the differentiation of ectodermally derived tissues...
  66. ncbi Calreticulin, and not calsequestrin, is the major calcium binding protein of smooth muscle sarcoplasmic reticulum and liver endoplasmic reticulum
    R E Milner
    Cardiovascular Disease Research Group, University of Alberta, Edmonton, Canada
    J Biol Chem 266:7155-65. 1991
    ..Calsequestrin and calreticulin may perform parallel functions in the lumen of the sarcoplasmic and endoplasmic reticulum...
  67. pmc Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
    Edward A Miao
    Institute for Systems Biology, Seattle, WA 98103, USA
    Proc Natl Acad Sci U S A 107:3076-80. 2010
    ..Furthermore, the specific detection of the virulence machinery permits the discrimination between pathogenic and nonpathogenic bacteria...
  68. ncbi Calreticulin
    K H Krause
    Division of Infectious Diseases, University Hospital, Geneva, Switzerland
    Cell 88:439-43. 1997
  69. ncbi Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation
    Nicolas Daudet
    Vertebrate Development Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 132:541-51. 2005
    ..Subsequently, Notch signalling within each such patch mediates lateral inhibition, restricting the proportion of cells that differentiate as hair cells so as to generate the fine-grained mixture of hair cells and supporting cells...
  70. pmc GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression
    Grazyna Rajkowska
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Neuropsychopharmacology 32:471-82. 2007
    ..A significant reduction in the density and size of GABAergic interneurons immunoreactive for calcium binding proteins was found predominantly in the dlPFC region...
  71. ncbi Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome
    P B Munroe
    Department of Paediatrics, Royal Free and University College Medical School, The Rayne Institute, London, UK
    Nat Genet 21:142-4. 1999
    ..69delG, IVS1-2A-->G and c.113T-->A. All three mutations predict a non-functional MGP. Our data indicate that mutations in MGP are responsible for KS and confirm its role in the regulation of extracellular matrix calcification...
  72. ncbi A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
    C Brou
    Unité de Biologie Moléculaire de l Expression Génique, URA 1773 CNRS, Institut Pasteur, Paris, France
    Mol Cell 5:207-16. 2000
    ..Furthermore, experiments carried out on TACE-/- bone marrow-derived monocytic precursor cells suggest that this metalloprotease plays a prominent role in the activation of the Notch pathway...
  73. ncbi The LETM1/YOL027 gene family encodes a factor of the mitochondrial K+ homeostasis with a potential role in the Wolf-Hirschhorn syndrome
    Karin Nowikovsky
    Max F Perutz Laboratories, Departments of Microbiology and Genetics, University of Vienna, Campus Vienna Biocenter, A 1030 Vienna, Austria
    J Biol Chem 279:30307-15. 2004
    ..Thus, YOL027/LETM1 are the first genes shown to encode factors involved in both K+ homeostasis and organelle volume control...
  74. ncbi Medial localization of mineralization-regulating proteins in association with Mönckeberg's sclerosis: evidence for smooth muscle cell-mediated vascular calcification
    C M Shanahan
    Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Circulation 100:2168-76. 1999
    ..Therefore, we examined gene expression in vessels with MS to determine whether there was evidence for a regulated calcification process in the vessel media...
  75. ncbi Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state
    T Tanaka
    Division of Molecular and Structural Biology, Ontario Cancer Institute, Toronto, Canada
    Nature 376:444-7. 1995
    ..The myristoyl group is sequestered in a deep hydrophobic pocket formed by many aromatic and other hydrophobic residues from five flanking helices...
  76. ncbi The stoned proteins regulate synaptic vesicle recycling in the presynaptic terminal
    T Fergestad
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Neurosci 19:5847-60. 1999
    ..These results suggest that the stoned proteins are essential for the recycling of synaptic vesicle membrane and are required for the proper sorting of synaptotagmin during endocytosis...
  77. ncbi Solution structure of the Reps1 EH domain and characterization of its binding to NPF target sequences
    S Kim
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Biochemistry 40:6776-85. 2001
    ..In addition, we characterized binding to a peptide containing a DPF sequence (Kd = 0.5 +/- 0.2 mM). The characterization of binding between the Reps1 EH domain and its target proteins provides information about their role in endocytosis...
  78. ncbi Patterns of expression of calcium binding proteins and neuronal nitric oxide synthase in different populations of hippocampal GABAergic neurons in mice
    Shozo Jinno
    Kyushu University, Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, 3 1 1 Maidashi, Migashi ku, 812 8582 Fukuoka, Japan
    J Comp Neurol 449:1-25. 2002
    We examined the expression of calcium binding proteins parvalbumin (PV), calretinin (CR), and calbindin D28K (CB), and neuronal nitric oxide synthase (nNOS) in gamma-aminobutyric acid (GABA)ergic neurons of the mouse hippocampus, with ..
  79. pmc Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex
    Mirko H H Schmidt
    William and Karen Davidson Laboratory of Brain Tumor Biology, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Mol Cell Biol 24:8981-93. 2004
    ..We propose that Alix inhibits EGFR internalization by attenuating the interaction between Cbl and SETA/CIN85 and by inhibiting Cbl-mediated ubiquitination of the EGFR...
  80. ncbi Overexpression of a putative maize calcineurin B-like protein in Arabidopsis confers salt tolerance
    Maoyan Wang
    State Key Laboratory of Agrobiotechnology and National Center for Plant Gene Research Beijing, China Agricultural University, Beijing 100094, China
    Plant Mol Biol 65:733-46. 2007
    ..This study has identified a putative maize CBL gene which functions in the salt stress-elicited calcium signaling and thus in the tolerance to salinity...
  81. pmc Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin
    Lenka Ivings
    The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool, L69 3BX, U K
    Biochem J 363:599-608. 2002
    ..These data suggest the possibility that neurocalcin delta functions in the control of clathrin-coated vesicle traffic...
  82. ncbi Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery
    Jez G Carlton
    Department of Infectious Diseases, King s College London School of Medicine, London, UK
    Science 316:1908-12. 2007
    ..Thus, HIV-1 budding and cytokinesis use a similar subset of cellular components to carry out topologically similar membrane fission events...
  83. ncbi Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function
    Robert D Burgoyne
    The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Trends Neurosci 27:203-9. 2004
    ..Recent work has established several physiological roles of these proteins, including diverse actions on gene expression, ion channel function, membrane traffic of ion channels and receptors, and the control of apoptosis...
  84. ncbi Neuronal Ca2+ signaling via caldendrin and calneurons
    Marina Mikhaylova
    AG Molecular Mechanisms of Plasticity, Department of Neurochemistry Molecular Biology, Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118 Magdeburg, Germany
    Biochim Biophys Acta 1763:1229-37. 2006
    ..Despite some significant structural differences it is conceivable that they are involved in similar Ca2+ regulated processes like caldendrin and neuronal calcium sensor proteins...
  85. ncbi Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples
    Yasuhide Yamada
    Medical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Cancer Sci 99:2193-9. 2008
    ..Our PCR-based single gene prediction strategy successfully predicted the overall survival and may lead to a better understanding of this disease subgroup...
  86. pmc Nedd4 regulates egress of Ebola virus-like particles from host cells
    Jiro Yasuda
    Division of Molecular Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita ku, Sapporo 060 0815, Japan
    J Virol 77:9987-92. 2003
    ..As expected, Tsg101 enhanced VP40-induced VLP release, and TsgDeltaC, which lacks its C-terminal half, inhibited VLP release. These results indicate that Nedd4, together with Tsg101, plays an important role in Ebola virus budding...
  87. pmc The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear
    Amy E Kiernan
    The Jackson Laboratory, Bar Harbor, Maine, USA
    PLoS Genet 2:e4. 2006
    ..These data demonstrate that JAG1-mediated Notch signaling is essential during early development for establishing the prosensory regions of the inner ear...
  88. ncbi Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke
    Pär Thored
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center A11, University Hospital, Lund, Sweden
    Glia 57:835-49. 2009
    ..The long-term accumulation of microglia with proneurogenic phenotype in the SVZ implies a supportive role of these cells for the continuous neurogenesis after stroke...
  89. ncbi Target selectivity in EF-hand calcium binding proteins
    Shibani Bhattacharya
    Department of Biochemistry, Center for Structural Biology, 5140 BIOSCI MRBIII, Vanderbilt University, Nashville, TN 37232 8725, USA
    Biochim Biophys Acta 1742:69-79. 2004
    EF-hand calcium binding proteins have remarkable sequence homology and structural similarity, yet their response to binding of calcium is diverse and they function in a wide range of biological processes...
  90. ncbi Inflammation regulates functional integration of neurons born in adult brain
    Katherine Jakubs
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    J Neurosci 28:12477-88. 2008
    ....
  91. pmc A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
    Jemima Cordle
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nat Struct Mol Biol 15:849-57. 2008
    ..Our data imply that cis- and trans-regulation may occur through the formation of structurally distinct complexes that, unexpectedly, involve the same surfaces on both ligand and receptor...
  92. pmc Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases
    Marina Tiemi Shio
    Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000559. 2009
    ..These findings not only identify one way by which the immune system is alerted to malarial infection but also are one of the first to suggest a role for tyrosine kinase signaling pathways in regulation of the NLRP3 inflammasome...
  93. ncbi Chlamydia infection of epithelial cells expressing dynamin and Eps15 mutants: clathrin-independent entry into cells and dynamin-dependent productive growth
    H Boleti
    Unite de Biologie des Interactions Cellulaires, Institut Pasteur, URA CNRS 1960, rue du Dr Roux, France
    J Cell Sci 112:1487-96. 1999
    ..Finally, dynamin is apparently not involved in the formation of phagocytic vesicles containing Chlamydia...
  94. ncbi Golgi duplication in Trypanosoma brucei requires Centrin2
    Cynthia Y He
    Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Science 310:1196-8. 2005
    ..Thus, a Centrin2-containing structure distinct from the basal body appears to mark the site for new Golgi assembly...
  95. ncbi Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse
    M Geppert
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 79:717-27. 1994
    ..We propose that synaptotagmin I is the major low affinity Ca2+ sensor mediating Ca2+ regulation of synchronous neurotransmitter release in hippocampal neurons...
  96. pmc Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p
    Sue L Jaspersen
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    J Cell Biol 159:945-56. 2002
    ....
  97. pmc TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent
    Douglas A Johnston
    Department of Molecular Biology and Biochemistry, University of California Irvine, 92697, USA
    Gene 435:36-44. 2009
    ..Full promoter activity also depends on an AP-1 site at -2.0 kb. These results indicate that canonical NFkappaB signaling is required for TNF induction of the notch ligand jagged-1 in EC...
  98. ncbi Calcium binding protein 1 of the protozoan parasite Entamoeba histolytica interacts with actin and is involved in cytoskeleton dynamics
    Nivedita Sahoo
    School of Life Sciences, Jawaharlal Nehru University, Aruna Asaf Ali Marg, New Delhi, 110067 India
    J Cell Sci 117:3625-34. 2004
    ....
  99. pmc Psoriasin (S100A7) expression and invasive breast cancer
    S Al-Haddad
    Department of Pathology University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Am J Pathol 155:2057-66. 1999
    ..0022). These results suggest that psoriasin may be a marker of aggressive behavior in invasive tumors and are consistent with a function as a chemotactic factor...
  100. pmc Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human
    Kobra Haghighi
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, Cincinnati, Ohio 45267, USA
    J Clin Invest 111:869-76. 2003
    ..These findings describe a naturally-occurring loss-of-function human PLN mutation (PLN null). In contrast to reported benefits of PLN ablation in mouse heart failure, humans lacking PLN develop lethal dilated cardiomyopathy...
  101. ncbi Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation
    B McCright
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 128:491-502. 2001
    ..These data identify novel developmental roles for Notch2 in kidney, heart and eye development...

Research Grants63

  1. Extracellular Zinc Buffering and A-beta Oligomerization
    GUIDO FAAS; Fiscal Year: 2012
    ..We have devised an ultra-fast in vitro kinetic measurement technique of Ca2+- binding to calcium binding proteins following flash photolysis of caged Ca2+ and created a compartmental kinetic model that resolved for the ..
  2. Stimulus processing in mammalian vestibular organs
    Ruth Anne Eatock; Fiscal Year: 2012
    ..generated in primary vestibular afferents, focusing on the contributions of intrinsic ion channels and calcium binding proteins. We will examine the origins of specific patterns of activity (firing patterns of action potentials, also ..
  3. Mechanisms of Calcium-Calmodulin Mediated Ion Channel Gating
    Richard Aldrich; Fiscal Year: 2013
    ..can be applied to any molecular system containing paired EF-hand binding sites, the largest category of calcium binding proteins in biology...
  4. Invivo role of S100A4 in OA pathophysiology
    Raghunatha R Yammani; Fiscal Year: 2013
    ....
  5. NMR Studies of Protein Side-Chain Dynamics
    MARK A RANCE; Fiscal Year: 2012
    ..abstract_text> ..
  6. Role of Synaptotagmins in Synaptic Plasticity in the Hippocampus
    Di Wu; Fiscal Year: 2013
    ..The proposed study will test the hypothesis that calcium binding proteins known as synaptotagmins regulate the trafficking of AMPA receptors to the postsynaptic membrane...
  7. Structure and Function of the Trypanosome Flagellar Membrane
    David M Engman; Fiscal Year: 2013
    ..2) To examine the interaction between intraflagellar transport and flagellar membrane trafficking. (3) To determine the lipid composition of the flagellar membrane and its contribution to protein targeting. ..
  8. Mouse fMRI and Calcium Dynamics in Alzheimer's Pathophysiology
    Herman Moreno; Fiscal Year: 2010
    ..It is also important to emphasize that advances in mouse fMRI can be easily applied to humans, e.g. evaluation of the response to a given treatment by brain fMRI parameters. ..
  9. STUDIES IN COCHLEAR HAIR CELL TRANSDUCTION
    Mary Ann Cheatham; Fiscal Year: 2013
    ..abstract_text> ..
  10. BILIRUBIN TOXICITY IN THE AUDITORY SYSTEM
    Steven Shapiro; Fiscal Year: 2005
    ..and markers, we have identified changes in expression of calcium/calmodulin-dependent kinase II and calcium binding proteins that seem to bear a consistent relationship with the pathophysiology and anatomy...
  11. EXPERIMENTAL AND CLINICAL STUDIES IN COLORECTAL CANCER
    Thomas McGarrity; Fiscal Year: 1993
    ..Parallel observations of changes in calcium binding proteins, mucus glycoproteins and cellular proliferation will be made in dimethylhydrazine-induced colon carcinoma ..
  12. HAIR CELL REGENERATION IN THE VESTIBULAR OTOLITH ORGANS
    Richard Baird; Fiscal Year: 2001
    ....
  13. RAT PAROTID EXOCYTOSIS
    David Quissell; Fiscal Year: 1992
    ..The studies should provide important new scientific information regarding the regulation of exocytosis...
  14. PROTEINS OF PHYSIOLOGICAL INTEREST: STRUCTURE-FUNCTION
    John Moffat; Fiscal Year: 1990
    ..chicken intestinal calcium binding protein; of human growth hormone; and of bovine or porcine intestinal calcium binding proteins depleted in calcium. If crystallizations prove successful, structure determination will be initiated...
  15. CALCIUM & CALCIUM BINDING PROTEINS IN THE EPIDERMIS
    JANET FAIRLEY; Fiscal Year: 1990
    ..Results of these studies and the technology employed will be applied to disease states such as psoriasis and skin neoplasms...
  16. CONFORMATION OF DENTAL SALIVARY MOLECULES
    Robert Baier; Fiscal Year: 1993
    ..The aPRP's like stathrin are known to be calcium binding proteins. The biological function common to all three of these salivary molecules is that of calcium coordination...
  17. Role of CaBP5 in retinal bipolar cells
    FRANCOISE J HAESELEER; Fiscal Year: 2010
    ....
  18. Neuronal Calcium Homeostasis and Synaptic Function
    Istvan Mody; Fiscal Year: 2006
    ..This triad is critical in severe neurological maladies including ischemia/stroke neurodegenerative disorders, and epilepsy. ..
  19. ROLE OF POLYAMINES IN CALMODULIN AND C-KINASE REGULATION
    John Walters; Fiscal Year: 1990
    ..These investigations should provide insight into the mechanism of action of polyamines, and of these key calcium-dependent regulatory proteins, in modulating cell proliferation and differentiation...
  20. STRUCTURE-FUNCTION RELATIONS IN CALCIUM BINDING PROTEIN
    Harel Weinstein; Fiscal Year: 1993
    ..g., inhibitors, drugs, other proteins) modulate the biological functions of calcium binding proteins will be identified from structural perturbations induced by calcium, by exploring the dynamical evolution ..
  21. CRYSTALLOGRAPHIC STUDIES OF TROPONIN C
    Muttaiya Sundaralingam; Fiscal Year: 1990
    ..The high resolution structural information on the troponin family of muscle proteins will help towards a better understanding of the molecular mechanism of muscular contraction and thus provide insights on various disease states...
  22. Effects of Lead on Calcium-Binding Proteins in Rats
    Jonathan Pevsner; Fiscal Year: 2007
    ..long-term objectives of the proposed research are [1] to test the hypothesis that lead interacts with calcium binding proteins of the C2 and annexin families, and [2] to identify genes and proteins of these calcium-binding families ..
  23. MOLECULAR CYTOLOGY OF A CA-BINDING CONTRACTILE PROTEIN
    JEFFREY SALISBURY; Fiscal Year: 1992
    ..In addition we will characterize calcium-binding to the protein and its proteolytic fragments and study the characteristics of flagellar root protein phosphorylation...
  24. REGULATION OF CYTOSKELETON AND MEMBRANE TRAFFIC BY P22
    Margarida Barroso; Fiscal Year: 2002
    ....
  25. BIOLOGICAL ROLE OF INTRACELLULAR CA2+ BINDING PROTEINS
    JOHN DEDMAN; Fiscal Year: 1991
    ..Our studies will provide definitive evidence for the physiological role of annexin VI in maintaining intracellular calcium homeostasis...
  26. STRESS RESPONSES AND APOPTOSIS
    Clark Distelhorst; Fiscal Year: 2003
    ....
  27. ORGANIZATION AND DEVELOPMENT OF AUDITORY NEOCORTEX
    NATHANIEL MCMULLEN; Fiscal Year: 1999
    ..fluorescent immunocytochemistry to determine the laminar projection of MGB neurons expressing different calcium binding proteins. In Aim 4, the developmental time-course for the arrival, in growth and arborization of thalamocortical ..
  28. Phenotype analysis of tyrosine hydroxylase neurons in rat and human cortices
    STEPHEN ASMUS; Fiscal Year: 2009
    ....
  29. 1,25-DIHYDROXYVITAMIN D RECEPTOR/FUNCTION IN NEW TARGETS
    MARIAN WALTERS; Fiscal Year: 1991
    ..Additional studies will extend studies of the effects of 1,25(OH)2D3 status/receptors on calcium binding proteins detected by 45CA binding to proteins transblotted to nitrocellulose membranes, on proteins modulated by ..
  30. DETERMINANTS OF CALCIUM BINDING IN NON EF HAND PROTEINS
    Lawrence Berliner; Fiscal Year: 2001
    ..2. Determine which residues of the protein are buried in membranes. 3. Determine the role of the amino acids involved in zinc binding. ..
  31. Aviv Model 215 Circular Dichroism Sepctrometer
    Lawrence Berliner; Fiscal Year: 2002
    ..The high, highly active Core Group faculty have projects covering: calcium binding proteins which fold via the molten globule; preparation and utilization of various myoglobin and carbonic ..
  32. Matrix proteins promote matrix vesicle mineralization
    Ann Rosenthal; Fiscal Year: 2007
    ..and small proteoglycans on articular cartilage matrix vesicle mineralization, and IN) the effects of the calcium binding proteins (osteopontin, SPARC, and matrix gla protein) on articular cartilage matrix vesicle mineralization...
  33. CALCIUM BINDING PROTEINS: STRUCTURE AND FUNCTION
    John Moffat; Fiscal Year: 1980
    ..d) To investigate the physical chemistry of the hormones, especially their ion binding, and evidence for domain structure. e) To investigate EXAFS spectroscopy of lanthanides and lanthanide derivates of CaBP, using CHESS. ..
  34. ALTERED CALCIUM REGULATION IN MOTONEURON VULNERABILITY
    Dennis Mosier; Fiscal Year: 1999
    ..The proposed studies will be carried out at the facilities of Baylor College of Medicine, under the sponsorship of Dr. Stanley Appel, who has a long-standing interest in ALS and other neurodegenerative diseases. ..
  35. LANTHANIDE PROBES--PROTEIN STRUCTURE/ELECTRON TRANSFER
    WILLIAM HORROCKS; Fiscal Year: 1999
    ....
  36. Serotonin Modulation of Orbital Cortex GABA Interneurons
    Heather Trantham Davidson; Fiscal Year: 2009
    ..of cells that differ in their electrophysiological properties, axonal targets and expression of calcium binding proteins and neuropeptides...
  37. IN VIVO ROLES OF A DROSOPHILA TRANSMITTER TRANSPORTER
    Michael Stern; Fiscal Year: 2000
    ..genes might encode ion channel subunits or regulatory molecules such as protein kinases, G-proteins, or calcium binding proteins. Because such genes are well conserved in evolution, human homologues of these genes will likely exist ..
  38. STRUCTURE AND FUNCTION OF THE INTESTINE BRUSH BORDER
    Paul Matsudaira; Fiscal Year: 1992
    ....
  39. CALCIUM-BINDING PROTEINS IN NERVE ENDINGS
    Joseph Bobich; Fiscal Year: 1990
    ..Because several diseases have been associated with alterations of neurotransmitter release, solution of the questions to be examined by this project should have broad implications for the improvement of mental health...
  40. REGULATION OF ICTACALCIN GENE EXPRESSION
    Angela Porta; Fiscal Year: 1999
    ..Ictacalcin belongs to the S100 family of calcium binding proteins, the members of which may play a role in mediating the effects of calcium in a variety of other tissues...
  41. SYNAPTIC ORGANIZATION OF THE BASOLATERAL AMYGDALA
    ALEXANDER MCDONALD; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  42. ALTERED CALCIUM HOMEOSTASIS TO DIAGNOSE ALZHEIMER'S
    Christine Peterson; Fiscal Year: 1992
    ..The mechanisms for the decline in cytosolic free calcium in Alzheimer's disease are unclear. The calcium binding proteins play a role in buffering intracellular calcium and studies are designed to determine whether they are ..
  43. STRUCTURE AND DYNAMICS OF CALBINDIN 9K BY 2D NMR
    Walter Chazin; Fiscal Year: 1992
    The functioning of the calcium messenger system is dependent on a series of highly homologous calcium binding proteins that are distinguished by a common helix-loop-helix structural motif in their binding sites...
  44. MOLECULAR MECHANISMS OF RENAL FIBROSIS
    ERIC NEILSON; Fiscal Year: 2007
    ..This understanding may be key to learning how we can further manipulate their participation in renal fibrosis. ..
  45. CELLULAR BASIS FOR DOPAMINE ACTIONS IN PREFRONTAL CORTEX
    SUSAN SESACK; Fiscal Year: 2002
    ..Elucidating the synaptic organization of the mesocortical DA system will improve knowledge of the cellular mechanisms of DA modulation in cognition and the pathophysiology and treatment of major psychiatric disorders. ..
  46. Rational Design and Analysis of Calcium Binding Protein
    Jenny Yang; Fiscal Year: 2005
    ..A comparison of the calcium binding sites in proteins determined by high-resolution methods with those of the originally designed target will be carried out to optimize our methods for design of calcium ..
  47. DYNAMIC ASPECTS OF AUDITORY SYNAPTIC TERMINALS
    ILSA SCHWARTZ; Fiscal Year: 1999
    ..between the different glutamate receptors (especially those which flux calcium) and the localization of calcium binding proteins. Finally, we will examine changes in receptor subunit localization at postsynaptic membrane ..
  48. Methylphenidate & gene expression in the rat brain.
    JOAN BAIZER; Fiscal Year: 2004
    ..abstract_text> ..
  49. Modulation of integrin function by cytoplasmic signals
    Ulhas Naik; Fiscal Year: 2007
    ..Further, characterization of CIB and its interactions with integrin alphaIIb-beta3 and Plk3 may help in delineating the mechanisms by which cytoplasmic signals modulate integrin function. ..
  50. INTRACELLULAR SIGNALS FOR LONG TERM SYNAPTIC DEPRESSION
    George Augustine; Fiscal Year: 2002
    ....
  51. Dynamic Imaging of Synaptic Inhibition
    George Augustine; Fiscal Year: 2002
    ..abstract_text> ..
  52. IMMUNOLOGICAL MECHANISM OF INFLAMMATION IN UVEITIS & EAE
    Grazyna Adamus; Fiscal Year: 2001
    ..3) Examine the role of cytokines and chemokines in the recruitment of cell to the eye in primary and recurrent uveitis associated with EAE after immunization of Lewis rats with MBP. ..
  53. CALCIUM IONS AND PRESYNAPTIC FUNCTION
    George Augustine; Fiscal Year: 2009
    ....
  54. Role of JAM Family in Angiogenesis
    Ulhas P Naik; Fiscal Year: 2010
    ..Further, elucidation of the role of JAM-A in endothelial cell proliferation and migration leading to angiogenesis will open up a mew line of investigation that is important in tumerigenesis and vascular biology. ..
  55. Mechanisms of Ataxin-1 Mediated Purkinje Cell Death
    PARMINDER VIG; Fiscal Year: 2007
    ..and immunohistochemical methods, focusing on the alterations in the expression of Purkinje cell markers, calcium binding proteins, and proteins involved in calcium signaling...
  56. Transmission at Synapsin-deficient Synapses
    George Augustine; Fiscal Year: 2006
    ..abstract_text> ..
  57. Recombinant T-cell Receptor Ligands for Treatment of Uveitis
    Grazyna Adamus; Fiscal Year: 2006
    ..To determine an effective treatment regimen for clinical rat AAU using RTLs. 2. To determine the abilities of RTLs to inhibit recurrent anterior and posterior uveitis in Lewis rats. [unreadable] [unreadable] [unreadable] [unreadable]..
  58. MECHANISM OF RETINAL DAMAGE IN AUTOIMMUNE RETINOPATHY
    Grazyna Adamus; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  59. Dynamic imaging of synaptic inhibition in the brain
    George Augustine; Fiscal Year: 2009
    ..abstract_text> ..
  60. Proteomics: The Next Grand Biological Challenge
    Walter Chazin; Fiscal Year: 2002
    ..A concentrated effort will be made to attract ethnic minorities, women and persons with disabilities as participants, organizers, and speakers. ..
  61. The Role of Fibulin-5 in Cardiovascular Remodeling
    Hiromi Yanagisawa; Fiscal Year: 2007
    ..abstract_text> ..
  62. Robust Methods for the Efficient Analysis and Integration of DNA Sequence Data
    Andrew S Allen; Fiscal Year: 2010
    ..abstract_text> ..
  63. Microarray Scanner and Accessories for MUSC
    WILLIAM ARGRAVES; Fiscal Year: 2006
    ..Specifically, funds are requested for purchasing an Affymetrix GeneChip Scanner 3000 Upgrade and a Fluidics Station 450 Upgrade. [unreadable] [unreadable] [unreadable]..