fibronectins

Summary

Summary: Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.

Top Publications

  1. ncbi Taking cell-matrix adhesions to the third dimension
    E Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Science 294:1708-12. 2001
  2. pmc Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases
    Jeffrey L Barnes
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Kidney Int 79:944-56. 2011
  3. pmc FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
    Joo Young Huh
    Division of Endocrinology, Diabetes, and Metabolism, BethIsrael Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 61:1725-38. 2012
  4. ncbi Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
    Tony Yeung
    Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA
    Cell Motil Cytoskeleton 60:24-34. 2005
  5. pmc TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    Hidenori Kasai
    Teijin Biomedical Laboratory, Medical Research Council Technology, 1 3 Burtonhole Lane, London, NW7 1AD, UK
    Respir Res 6:56. 2005
  6. pmc The relationship between force and focal complex development
    Catherine G Galbraith
    Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 159:695-705. 2002
  7. ncbi Activation of integrin function by nanopatterned adhesive interfaces
    Marco Arnold
    University of Heidelberg, Institute for Physical Chemistry, Biophysical Chemistry, INF 253, 69120 Heidelberg, Germany
    Chemphyschem 5:383-8. 2004
  8. pmc Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators
    Karl E Kadler
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Curr Opin Cell Biol 20:495-501. 2008
  9. pmc Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion
    X N Meng
    Laboratory of Medical Genetics, Department of Biology, Harbin Medical University, Harbin 150086, China
    Br J Cancer 101:327-34. 2009
  10. pmc The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin
    Hilary A Kenny
    Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 118:1367-79. 2008

Research Grants

  1. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
  2. Balakuntalam S Kasinath; Fiscal Year: 2016
  3. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
  4. Howard B Lieberman; Fiscal Year: 2016
  5. Karen Block; Fiscal Year: 2015
  6. RSK-2 regulates integrin-mediated adhesion and migration
    JOE WILLIAM RAMOS; Fiscal Year: 2013
  7. IGFBP-5 and Hsp70 in Extracellular Matrix Homeostasis and Fibrosis
    Kristen L Veraldi; Fiscal Year: 2013
  8. YVES CLAUDE GORIN; Fiscal Year: 2014
  9. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
  10. Regulation of Fibronectin Matrix Assembly by uPAR
    PAULA J MC KEOWN-LONGO; Fiscal Year: 2012

Detail Information

Publications476 found, 100 shown here

  1. ncbi Taking cell-matrix adhesions to the third dimension
    E Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Science 294:1708-12. 2001
    ..These distinctive in vivo 3D-matrix adhesions differ in structure, localization, and function from classically described in vitro adhesions, and as such they may be more biologically relevant to living organisms...
  2. pmc Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases
    Jeffrey L Barnes
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Kidney Int 79:944-56. 2011
    ..Information on the role of ROS in mesangial cell and fibroblast signaling is incomplete, and further research on myofibroblast differentiation during fibrosis is warranted...
  3. pmc FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
    Joo Young Huh
    Division of Endocrinology, Diabetes, and Metabolism, BethIsrael Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 61:1725-38. 2012
    ..No prior study has reported on the physiological regulation and role of circulating irisin and FNDC5 in humans...
  4. ncbi Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
    Tony Yeung
    Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA
    Cell Motil Cytoskeleton 60:24-34. 2005
    ..These results support the hypothesis that mechanical factors impact different cell types in fundamentally different ways, and can trigger specific changes similar to those stimulated by soluble ligands...
  5. pmc TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    Hidenori Kasai
    Teijin Biomedical Laboratory, Medical Research Council Technology, 1 3 Burtonhole Lane, London, NW7 1AD, UK
    Respir Res 6:56. 2005
    ..We examined whether the potent fibrogenic cytokine TGF-beta1 could induce epithelial mesenchymal transition (EMT) in the human alveolar epithelial cell line, A549, and investigated the signaling pathway of TGF-beta1-mediated EMT...
  6. pmc The relationship between force and focal complex development
    Catherine G Galbraith
    Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 159:695-705. 2002
    ....
  7. ncbi Activation of integrin function by nanopatterned adhesive interfaces
    Marco Arnold
    University of Heidelberg, Institute for Physical Chemistry, Biophysical Chemistry, INF 253, 69120 Heidelberg, Germany
    Chemphyschem 5:383-8. 2004
    ..We propose that the range between 58-73 nm is a universal length scale for integrin clustering and activation, since these properties are shared by a variety of cultured cells...
  8. pmc Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators
    Karl E Kadler
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Curr Opin Cell Biol 20:495-501. 2008
    ..This review puts forward a working hypothesis for how fibronectin and integrins (the organizers) determine the site of fibril assembly, and collagens V and XI (the nucleators) initiate collagen fibrillogenesis...
  9. pmc Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion
    X N Meng
    Laboratory of Medical Genetics, Department of Biology, Harbin Medical University, Harbin 150086, China
    Br J Cancer 101:327-34. 2009
    ..However, the mechanism by which extracellular matrix fibronectin stimulates lung cancer cell migration and invasion through FAK remains to be investigated...
  10. pmc The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin
    Hilary A Kenny
    Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 118:1367-79. 2008
    ..These findings indicate that MMP-2 expressed by metastatic OvCa cells functionally regulates their attachment to peritoneal surfaces...
  11. pmc Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
    M Delcommenne
    British Columbia Cancer Agency, Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6 Canada
    Proc Natl Acad Sci U S A 95:11211-6. 1998
    ..ILK is thus a receptor-proximal effector for the Pi(3)K-dependent, extracellular matrix and growth factor mediated, activation of PKB/AKT, and inhibition of GSK-3...
  12. pmc Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment
    E Tzima
    Department of Vascular Biology, The Scripps Research Institute, 10550 N.Torrey Pines Road, La Jolla, CA 92037, USA
    EMBO J 20:4639-47. 2001
    ..This transient inhibition is necessary for cytoskeletal alignment in the direction of flow. The results therefore define the role of integrins and Rho in a pathway leading to endothelial cell adaptation to flow...
  13. ncbi Adult bone marrow stromal cells differentiate into neural cells in vitro
    J Sanchez-Ramos
    Department of Neurology, University of South Florida, Tampa, USA
    Exp Neurol 164:247-56. 2000
    ..When labeled human or mouse BMSC were cultured with rat fetal mesencephalic or striatal cells, a small proportion of BMSC-derived cells differentiated into neuron-like cells expressing NeuN and glial cells expressing GFAP...
  14. ncbi Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
    E L George
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Development 119:1079-91. 1993
    ..The nature of these embryonic defects leads to reevaluation of suggested roles for fibronectin during early development based on results obtained in vitro and in embryos of other species...
  15. pmc Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion
    Kris A DeMali
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Biol 159:881-91. 2002
    ..The recruitment of the Arp2/3 complex to vinculin may be one mechanism through which actin polymerization and membrane protrusion are coupled to integrin-mediated adhesion...
  16. pmc Differential regulation of cell motility and invasion by FAK
    Datsun A Hsia
    The Scripps Research Institute, Dept of Immunology, IMM26, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    J Cell Biol 160:753-67. 2003
    ..Our studies support a dual role for FAK in promoting cell motility and invasion through the activation of distinct signaling pathways...
  17. ncbi Fibronectin at a glance
    Roumen Pankov
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 115:3861-3. 2002
  18. doi Up-regulated microRNA-143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression
    Xiaoying Zhang
    Department of Medical Genetics, Second Military Medical University, Shanghai, PR China
    Hepatology 50:490-9. 2009
    ..Additionally, fibronectin type III domain containing 3B (FNDC3B), which regulates cell motility, was identified as the direct and functional target of miR-143 both in vivo and in vitro...
  19. doi Fibronectin: a multidomain host adhesin targeted by bacterial fibronectin-binding proteins
    Brian Henderson
    Department of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, UK
    FEMS Microbiol Rev 35:147-200. 2011
    ..This article provides an update on our current understanding of FnBPs from both Gram-negative and Gram-positive bacteria and their proposed roles in bacterial colonization, bacterial virulence and bacteria-host interactions...
  20. pmc Fibronectin growth factor-binding domains are required for fibroblast survival
    Fubao Lin
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA
    J Invest Dermatol 131:84-98. 2011
    ..The findings that fibroblast survival is dependent on FN-GFBD underscore the critical importance of pericellular matrix for cell survival and have significant implications for cutaneous wound healing and regeneration...
  21. ncbi Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1
    Teet Velling
    Institute of Medical Biochemistry and Microbiology, 75123 Uppsala, Sweden
    J Biol Chem 277:37377-81. 2002
    ..Thus, collagen deposition is regulated by the cells, both indirectly through integrin alpha(5)beta(1)-dependent polymerization of fibronectin and directly through collagen-binding integrins...
  22. ncbi Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy
    L Yuan
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, USA
    Oncogene 26:2563-73. 2007
    ....
  23. ncbi Fibronectin-binding protein acts as Staphylococcus aureus invasin via fibronectin bridging to integrin alpha5beta1
    B Sinha
    Division of Infectious Diseases, Geneva Medical School, Swizterland
    Cell Microbiol 1:101-17. 1999
    ..aureus FnBPs and host cell integrin alpha5beta1 is a conserved mechanism for S. aureus invasion of human cells. This may prove useful in developing new therapeutic and vaccine strategies for S. aureus infections...
  24. ncbi Tissue transglutaminase in normal and abnormal wound healing: review article
    E A M Verderio
    School of Science, Nottingham Trent University, Nottingham, United Kingdom
    Amino Acids 26:387-404. 2004
    ....
  25. pmc Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis
    Yok Ai Que
    Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland
    J Exp Med 201:1627-35. 2005
    ..Thus, fibrinogen and fibronectin binding could cooperate for S. aureus valve colonization and endothelial invasion in vivo...
  26. pmc Fibronectins in vascular morphogenesis
    Sophie Astrof
    Greenberg Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA
    Angiogenesis 12:165-75. 2009
    ..We review genetic studies examining functions of fibronectin and its splice variants during embryonic cardiovascular development, and discuss potential roles of fibronectin in vascular disease and tumor angiogenesis...
  27. pmc Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin
    Sophie Astrof
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Dev Biol 311:11-24. 2007
    ..Our studies indicate that the presence or absence of EIIIA and EIIIB exons alters the function of FN and demonstrate the requirement for these alternatively spliced exons in cardiovascular development...
  28. pmc Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction
    Pere Roca-Cusachs
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 106:16245-50. 2009
    ....
  29. doi Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index
    Andreas Stengel
    Charité Center for Internal Medicine and Dermatology, Division of General Internal and Psychosomatic Medicine, Charite Universitatsmedizin Berlin, Campus Mitte, Berlin, Germany
    Peptides 39:125-30. 2013
    ..The increase of irisin under conditions of obesity may indicate a physiological function to improve glucose tolerance which is often impaired in obese subjects...
  30. doi Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology, and Nutrition, Hospital of Girona Dr Josep Trueta, Girona, Spain
    J Clin Endocrinol Metab 98:E769-78. 2013
    ..Recently irisin (encoded by Fndc5 gene) has been reported to stimulate browning and uncoupling protein 1 expression in sc adipose tissue of mice...
  31. ncbi Stimulation of integrin-mediated cell contractility by fibronectin polymerization
    D C Hocking
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 275:10673-82. 2000
    ....
  32. ncbi Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin
    Guoying Jiang
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, New York 11027, USA
    Nature 424:334-7. 2003
    ....
  33. pmc Integrins control motile strategy through a Rho-cofilin pathway
    Erik H J Danen
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Cell Biol 169:515-26. 2005
    ..Thus, alterations in integrin expression profiles allow cells to modulate several critical aspects of the motile machinery through Rho GTPases...
  34. ncbi Fibronectin-dependent collagen I deposition modulates the cell response to fibronectin
    Jane Sottile
    Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 293:C1934-46. 2007
    ....
  35. pmc Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth
    Dalit Barkan
    Department of Biology, Faculty of Sciences, Haifa University, Haifa, Israel
    Eur J Cancer 46:1181-8. 2010
    ....
  36. pmc Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation
    Ssang Taek Lim
    Department of Reproductive Medicine, Moores Cancer Center, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:21526-36. 2010
    ..This work supports the use of FAK inhibitors to disrupt neovascularization...
  37. pmc The role of the p38 MAPK signaling pathway in high glucose-induced epithelial-mesenchymal transition of cultured human renal tubular epithelial cells
    Zhi Mei Lv
    Department of Nephrology, Provincial Hospital Affliated to Shandong University, Jinan, China
    PLoS ONE 6:e22806. 2011
    ..In this study, the role of p38 MAPK in AP-1 activation and in the EMT in the human proximal tubular epithelial cell line (HK-2) under high glucose concentration conditions is investigated...
  38. pmc The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling
    Margit Hagel
    Beth Israel Deaconess Medical Center Harvard Medical School, Vascular Research Division, Department of Pathology, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 22:901-15. 2002
    ....
  39. ncbi Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
    D D Schlaepfer
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    Nature 372:786-91. 1994
    ..Phosphorylation of FAK at Tyr 925 upon fibronectin stimulation creates an SH2-binding site for GRB2 which may link integrin engagement to the activation of the Ras/MAPK signal transduction pathway...
  40. pmc Tissue transglutaminase is an integrin-binding adhesion coreceptor for fibronectin
    S S Akimov
    Department of Biochemistry, American Red Cross, Rockville, Maryland 20855, USA
    J Cell Biol 148:825-38. 2000
    ..Together our results demonstrate that tissue transglutaminase mediates the interaction of integrins with fibronectin, thereby acting as an integrin-associated coreceptor to promote cell adhesion and spreading...
  41. ncbi TGF-beta signaling and the fibrotic response
    Andrew Leask
    Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill St, London, UK NW3 2PF
    FASEB J 18:816-27. 2004
    ....
  42. doi The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domain
    Mikael M Martino
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    FASEB J 24:4711-21. 2010
    ..We show that FN III12-14 is a highly promiscuous ligand for GFs and also holds great potential in clinical healing applications...
  43. pmc Modulation of Rac localization and function by dynamin
    Gunther Schlunck
    Division of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:256-67. 2004
    ..These data suggest an indispensable role of dynamin in Rac trafficking to allow for lamellipodia formation and cell spreading...
  44. ncbi Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts
    Xu Shi-Wen
    Royal Free Hospital, University College London, London, UK
    Arthritis Rheum 56:4189-94. 2007
    ..The goal of this study was to assess whether ET-1 is a downstream mediator of the profibrotic effects of TGFbeta in lung fibroblasts...
  45. ncbi Regulation of integrin function by the urokinase receptor
    Y Wei
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 273:1551-5. 1996
    ..These data provide a paradigm for regulation of integrins in which a nonintegrin membrane receptor interacts with and modifies the function of activated integrins...
  46. pmc The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis
    Erik H J Danen
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 159:1071-86. 2002
    ..Our findings demonstrate that the pattern of fibronectin receptors expressed on a cell dictates the ability of fibronectin to stimulate RhoA-mediated organization of cell matrix adhesions...
  47. pmc Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability
    Mikael M Martino
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Biomaterials 30:1089-97. 2009
    ..This work shows how integrin-dependant cellular interactions with the ECM can be engineered to control stem cell fate, within a system appropriate for both 3D cell culture and tissue engineering...
  48. pmc Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6
    Jonathan D Humphries
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester, UK
    Sci Signal 2:ra51. 2009
    ..This proteomics workflow now opens the way to further dissection and systems-level analyses of adhesion signaling...
  49. ncbi Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils
    J Taipale
    Departments of Virology, University of Helsinki, Finland
    J Histochem Cytochem 44:875-89. 1996
    ..The present results indicate that latent TGF-beta 1 complexes are components of the extracellular matrix and suggest that alterations of the pericellular matrix could result in aberrant TGF-beta signaling...
  50. ncbi Integrin-mediated interactions between human bone marrow stromal precursor cells and the extracellular matrix
    S Gronthos
    Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Bone 28:174-81. 2001
    ..Furthermore, these data suggest a possible role for the beta1 integrin subfamily during the development of stromal precursor cells into functional osteoblast-like cells...
  51. ncbi Fibronectin requirement in branching morphogenesis
    Takayoshi Sakai
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    Nature 423:876-81. 2003
    ..Thus, fibronectin expression is required for cleft formation in branching morphogenesis associated with the conversion of cell-cell adhesions to cell-matrix adhesions...
  52. pmc Fibronectin is an important regulator of flow-induced vascular remodeling
    Hou Yu Chiang
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 29:1074-9. 2009
    ....
  53. pmc New insights into form and function of fibronectin splice variants
    E S White
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    J Pathol 216:1-14. 2008
    ..Here we summarize the phenotypes of the mouse strains having targeted mutations in the FN gene, which may lead to novel insights linking function of alternatively spliced isoforms of fibronectin to human pathologies...
  54. ncbi Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase
    G E Hannigan
    Cancer Biology Research Program, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada
    Nature 379:91-6. 1996
    ..We propose that ILK is a receptor-proximal protein kinase regulating integrin-mediated signal transduction...
  55. pmc Focal adhesion kinase modulates cell adhesion strengthening via integrin activation
    Kristin E Michael
    Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Mol Biol Cell 20:2508-19. 2009
    ..This work demonstrates a novel role for FAK in integrin activation and the time-dependent generation of cell-ECM forces...
  56. ncbi Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling
    P Schedin
    Center for Cancer Causation and Prevention, AMC Cancer Research Center, Denver, CO 80214, USA
    J Cell Sci 113:795-806. 2000
    ..These data suggest that during post-lactational involution, fibronectin fragments may contribute to epithelial cell loss and dissolution of mammary alveoli by inducing matrix degrading proteinases...
  57. pmc Treponema pallidum fibronectin-binding proteins
    Caroline E Cameron
    Box 357185, Department of Medicine, Division of Infectious Diseases, University of Washington, Seattle, WA 98195, USA
    J Bacteriol 186:7019-22. 2004
    ..These results suggest Tp0155 and Tp0483 are fibronectin-binding proteins mediating T. pallidum-host interactions...
  58. ncbi Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells
    Dong Young Rhyu
    Ewha Womans University College of Pharmacy, 11 1 Daehyun Dong, Sedaimun gu, Seoul 120 750, Korea
    J Am Soc Nephrol 16:667-75. 2005
    ..Thus, this data suggest that ROS play an important role in TGF-beta1-induced EMT primarily through activation of MAPK and subsequently through ERK-directed activation of Smad pathway in proximal tubular epithelial cells...
  59. ncbi Cell distribution of stress fibres in response to the geometry of the adhesive environment
    Manuel Thery
    Biologie du cycle cellulaire et de la motilité, UMR144, CNRS, Institut Curie, Paris, France
    Cell Motil Cytoskeleton 63:341-55. 2006
    ..We conclude that cells of a given area can generate the same total sum of tractional forces but that these tractional forces are differently spaced depending on the spatial distribution of its adherence contacts...
  60. ncbi p38 inhibitors prevent TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts
    Tobias Meyer-Ter-Vehn
    Department of Ophthalmology, University of Wurzburg, Germany
    Invest Ophthalmol Vis Sci 47:1500-9. 2006
    ....
  61. pmc Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism
    Errol S Wijelath
    Department of Surgery, Division of Vascular Surgery, Veterans Affairs Puget Sound Health Care System and the University of Washington School of Medicine, Seattle, USA
    Circ Res 99:853-60. 2006
    ..These data also highlight a new function for the Fn C-terminal heparin-binding domain that may have important implications for angiogenesis and tumor growth...
  62. pmc Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis
    Xiao Mei Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 203:2895-906. 2006
    ..This study indicates a pivotal role for cav-1 in ECM regulation and suggests a novel therapeutic target for patients with pulmonary fibrosis...
  63. pmc NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts
    Corry D Bondi
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Am Soc Nephrol 21:93-102. 2010
    ..Taken together, these results suggest that TGF-beta1-induced conversion of fibroblasts to a myofibroblast phenotype involves a signaling cascade through Smad3, NAD(P)H oxidase, and ERK1/2...
  64. pmc Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation
    Ana M Pasapera
    Cell Biology and Physiology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 188:877-90. 2010
    ....
  65. pmc N-cadherin cell-cell adhesion complexes are regulated by fibronectin matrix assembly
    Craig T Lefort
    Department of Biomedical Engineering, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 286:3149-60. 2011
    ....
  66. pmc pVHL function is essential for endothelial extracellular matrix deposition
    Nan Tang
    Molecular Biology Section, MC 0377, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093 0377, USA
    Mol Cell Biol 26:2519-30. 2006
    ....
  67. ncbi Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing
    Kaustabh Ghosh
    Department of Biomedical Engineering, SUNY at Stony Brook, Stony Brook, New York 11794 8165, USA
    Tissue Eng 12:601-13. 2006
    ..Such constructs might be of great benefit in clinical settings where rapid formation of new tissue is needed...
  68. ncbi Transforming growth factor-beta1 differentially mediates fibronectin and inflammatory cytokine expression in kidney tubular cells
    Weier Qi
    Dept of Medicine, Level 3, Wallace Freeborn Professorial Block, Royal North Shore Hospital, St Leonards, NSW, Australia
    Am J Physiol Renal Physiol 291:F1070-7. 2006
    ..Conversely, decreased expression of TGF-beta(1) results in increased TGF-beta(2), TGF-beta(3), AP-1, and pSmad2 that potentially mediates the observed increase in fibronectin...
  69. doi The extracellular matrix affects axonal regeneration in peripheral neuropathies
    S C Previtali
    Department of Neurology and INSPE, Neuropathology Unit, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy
    Neurology 71:322-31. 2008
    ..Recent evidence in animal models suggests that components of the extracellular matrix (ECM) play a primary role in peripheral nerve degeneration and regeneration...
  70. pmc Metastatic outgrowth encompasses COL-I, FN1, and POSTN up-regulation and assembly to fibrillar networks regulating cell adhesion, migration, and growth
    Johanna Soikkeli
    Department of Pathology, Haartman Institute, P O Box 21 Haartmaninkatu 3, FI 00014 Helsinki, Finland
    Am J Pathol 177:387-403. 2010
    ....
  71. pmc Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin
    Jae Hyun Park
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Neoplasia 13:320-6. 2011
    ....
  72. doi Early corneal wound healing and inflammatory responses after refractive lenticule extraction (ReLEx)
    Andri K Riau
    Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore
    Invest Ophthalmol Vis Sci 52:6213-21. 2011
    ..To compare the early corneal wound repair and inflammatory responses after refractive lenticule extraction (ReLEx) and LASIK...
  73. doi Effect of different femtosecond laser-firing patterns on collagen disruption during refractive lenticule extraction
    Andri K Riau
    Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore
    J Cataract Refract Surg 38:1467-75. 2012
    ..To evaluate the changes in corneal collagen architecture subjected to different laser-firing patterns during refractive lenticule extraction...
  74. pmc Regulation of podosome formation, microglial migration and invasion by Ca(2+)-signaling molecules expressed in podosomes
    Tamjeed A Siddiqui
    Toronto Western Research Institute, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada
    J Neuroinflammation 9:250. 2012
    ..Here, we hypothesized that podosomes contain Ca(2+)-signaling machinery, and that podosome expression and function depend on Ca(2+) influx and specific ion channels...
  75. ncbi Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisation
    Franziska Agerer
    Zentrum für Infektionsforschung, Universitat Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    J Cell Sci 118:2189-200. 2005
    ..Cooperation between FAK, Src and cortactin in integrin-mediated internalisation of bacteria also suggests a molecular scenario of how engagement of integrins could be coupled to membrane endocytosis...
  76. pmc Human mesenchymal stem cell differentiation on self-assembled monolayers presenting different surface chemistries
    Jennifer E Phillips
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    Acta Biomater 6:12-20. 2010
    ....
  77. pmc The adhesion modulating properties of tenascin-W
    Florence Brellier
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    Int J Biol Sci 8:187-94. 2012
    ....
  78. doi Refractive lenticule re-implantation after myopic ReLEx: a feasibility study of stromal restoration after refractive surgery in a rabbit model
    Romesh I Angunawela
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 53:4975-85. 2012
    ..To investigate the potential of refractive lenticule (RL) storage and re-implantation in vivo as a method for reversing RL extraction (ReLEx) and restoring corneal stromal volume...
  79. ncbi A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription
    M L Matter
    Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 276:27757-63. 2001
    ..Mitogen-activated protein kinase did not appear to be necessary for the activation of bcl-2 transcription. Therefore, our work characterizes the pathway that mediates the effect of integrins on bcl-2 transcription and cell survival...
  80. ncbi Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991
    Anderson J Ferreira
    Department of Morphology, Biological Sciences Institute Federal University of Minas Gerais, Belo Horizonte, MG, 31 270 901, Brazil
    Life Sci 81:916-23. 2007
    ..AVE treatment also attenuated the decrease in systolic tension and +/-dT/dt and exacerbated the vasodilatation induced by ISO. These results show that AVE has a cardioprotective effect on ISO-induced cardiac remodeling...
  81. doi Intercellular and extracellular mechanotransduction in cardiac myocytes
    J Yasha Kresh
    Department of Cardiothoracic Surgery, Drexel University College of Medicine, 245 North 15th Street, MS 111, Philadelphia, PA 19102, USA
    Pflugers Arch 462:75-87. 2011
    ....
  82. doi Measuring integrated cellular mechanical stress response at focal adhesions by optical tweezers
    François Bordeleau
    Laval University, Center for Optics, Photonics and Lasers, Quebec, G1K 7P4, Canada
    J Biomed Opt 16:095005. 2011
    ..The differences in the forces from untreated and treated cells are resolved by the optical tweezers experiment...
  83. ncbi Integrin trafficking regulates adhesion to fibronectin during differentiation of mouse peri-implantation blastocysts
    J F Schultz
    C S Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Dev Genet 21:31-43. 1997
    ..Trafficking of alpha 5 beta 1, and possibly other integrins, to the apical surface of trophoblast cells appears to be a critical step in the differentiation of the mouse blastocyst to an invasive phenotype...
  84. ncbi Fibronectin protects prostate cancer cells from tumor necrosis factor-alpha-induced apoptosis via the AKT/survivin pathway
    Mara Fornaro
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:50402-11. 2003
    ..These findings indicate that survivin is required to maintain a critical anti-apoptotic threshold in prostate cancer cells and identify integrin signaling as a crucial survival pathway against death receptor-mediated apoptosis...
  85. ncbi Role of the proteasome in TGF-beta signaling in lens epithelial cells
    Matthew R Hosler
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07101 1709, USA
    Invest Ophthalmol Vis Sci 47:2045-52. 2006
    ..The present study addresses proteasome involvement in TGF-beta induced, cataract-associated gene activation in human lens cells...
  86. pmc Human corneal fibrosis: an in vitro model
    Dimitris Karamichos
    Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 51:1382-8. 2010
    ..This model mimics corneal development. The authors postulate that with the addition of TGF-beta1, a 3-D corneal scar model can be generated...
  87. doi Integrin alpha3 subunit regulates events linked to epithelial repair, including keratinocyte migration and protein expression
    Tingting Wen
    Center for Biochemistry, Cologne, Germany
    Wound Repair Regen 18:325-34. 2010
    ..Thus, down-regulation of alpha3beta1 integrin recapitulates crucial events governing keratinocyte migration associated with wound healing and tissue repair...
  88. doi Lack of fibronectin-EDA promotes survival and prevents adverse remodeling and heart function deterioration after myocardial infarction
    Fatih Arslan
    Laboratory of Experimental Cardiology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Circ Res 108:582-92. 2011
    ..The extracellular matrix protein fibronectin-EDA (EIIIA; EDA) is upregulated after tissue injury and may act as a "danger signal" for leukocytes to cause adverse cardiac remodeling after infarction...
  89. pmc MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin
    Feng Shi
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    J Cell Sci 124:4039-50. 2011
    ..The dual dependence of ECM fibronectin turnover on extracellular proteolysis and endocytosis highlights the complex regulatory mechanisms that control ECM remodeling to ensure maintenance of proper tissue function...
  90. doi Analysis of the distinct functions of growth factors and tissue culture substrates necessary for the long-term self-renewal of human embryonic stem cell lines
    Melissa A Baxter
    Faculty of Life Sciences, The University of Manchester, 2nd Floor CTF Building, Oxford Road, Manchester, UK
    Stem Cell Res 3:28-38. 2009
    ..Inhibition studies showed that β1 integrin-dependent attachment of hES cells to fibronectin was at least partially via the α5 subunit but independent of integrin αV...
  91. ncbi Calpain-mediated proteolysis of talin regulates adhesion dynamics
    Santos J Franco
    Cellular and Molecular Biology Program, University of Wisconsin, Madison, WI 53706, USA
    Nat Cell Biol 6:977-83. 2004
    ..Together, these findings identify calpain-mediated proteolysis of talin as a mechanism by which adhesion dynamics are regulated...
  92. pmc Gene expression profiling identifies Fibronectin 1 and CXCL9 as candidate biomarkers for breast cancer screening
    E Ruiz-Garcia
    Breast Cancer Translational Research Unit, UPRES EA03535, Universite Paris XI, Institut Gustave Roussy, Villejuif, France
    Br J Cancer 102:462-8. 2010
    ..There is a need to develop blood-based bioassays for breast cancer (BC) screening. In this study, differential gene expression between BC samples and benign tumours was used to identify candidate biomarkers for blood-based screening...
  93. ncbi Fibronectin is a survival factor for differentiated osteoblasts
    R K Globus
    NASA Ames Research Center, Moffett Field, CA 94035, USA Departments of Medicine, Stomatology and Anatomy, University of California, San Francisco, CA 94143, USA
    J Cell Sci 111:1385-93. 1998
    ..These data suggest that fibronectin, together with transforming growth factor-beta1, may affect bone formation, in part by regulating the survival of osteoblasts...
  94. ncbi Cell surface tissue transglutaminase is involved in adhesion and migration of monocytic cells on fibronectin
    S S Akimov
    Department of Biochemistry, The Holland Laboratory, American Red Cross, Rockville, MD 20855, USA
    Blood 98:1567-76. 2001
    ..These data demonstrate that cell surface tTG serves as an integrin-associated adhesion receptor that might be involved in extravasation and migration of monocytic cells into tissues containing Fn matrices during inflammation...
  95. ncbi The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing
    Yung Feng Liao
    Center for Engineering in Medicine and Surgical Service, Massachusetts General Hospital and Harvard Medical School, the Shriners Burns Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 277:14467-74. 2002
    ..EIIIA-containing fibronectins are prominently expressed during embryogenesis and wound healing and appear to mediate changes in cell adhesion ..
  96. ncbi Connective tissue growth factor (CTGF) acts as a downstream mediator of TGF-beta1 to induce mesenchymal cell condensation
    Jason J Song
    Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Cell Physiol 210:398-410. 2007
    ..CTGF is also involved in up-regulating FN and suppressing Sox9 expression during TGF-beta1 induced MC condensation...
  97. ncbi Fibronectin- and vitronectin-induced microglial activation and matrix metalloproteinase-9 expression is mediated by integrins alpha5beta1 and alphavbeta5
    Richard Milner
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 20550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Immunol 178:8158-67. 2007
    ..Furthermore, it provides the first evidence that the alpha(5)beta(1) and alpha(v)beta(5) integrins are important mediators of microglial activation...
  98. pmc Fibronectin binding and proteolytic degradation by Leishmania and effects on macrophage activation
    Manjusha M Kulkarni
    Division of Infectious Diseases and Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    Infect Immun 76:1738-47. 2008
    ....
  99. pmc A catalytic role of heparin within the extracellular matrix
    Maria Mitsi
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 283:34796-807. 2008
    ..Catalytic activation of the extracellular matrix might be an important mechanism for heparin to regulate function during normal and disease states...
  100. pmc Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation
    Ryan E Feaver
    Associate Professor, Department of Biomedical Engineering, University of Virginia, Box 800759, Health System, Charlottesville, VA 22908, USA
    Circ Res 106:1703-11. 2010
    ..The extracellular matrix protein fibronectin (FN) is focally deposited in regions of atherosclerosis, where it contributes to inflammatory signaling...
  101. pmc Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial cells
    Meenalakshmi M Mariappan
    Mail Code 7882, Department of Medicine Division of Nephrology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Renal Physiol 300:F219-30. 2011
    ....

Research Grants80

  1. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ....
  2. Balakuntalam S Kasinath; Fiscal Year: 2016
    ..Upstream regulators and downstream effectors of GSK 3beta in transcription and translation pathways involved in matrix protein synthesis will be explored in renal tissues as stated in Aim 1. ..
  3. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
    ....
  4. Howard B Lieberman; Fiscal Year: 2016
    ....
  5. Karen Block; Fiscal Year: 2015
    ..This work may have major therapeutic implications. ..
  6. RSK-2 regulates integrin-mediated adhesion and migration
    JOE WILLIAM RAMOS; Fiscal Year: 2013
    ..This will determine if these proteins are suitable targets for the development of new adhesion specific disease therapies. In particular we will test if RSK2 can serve as a potential new therapeutic target in glioma. ..
  7. IGFBP-5 and Hsp70 in Extracellular Matrix Homeostasis and Fibrosis
    Kristen L Veraldi; Fiscal Year: 2013
    ..End of Abstract) ..
  8. YVES CLAUDE GORIN; Fiscal Year: 2014
    ..abstract_text> ..
  9. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    ..These studies will fill key gaps in our understanding of the basic signaling events regulating cell movement and underlying processes such as tumor spread. ..
  10. Regulation of Fibronectin Matrix Assembly by uPAR
    PAULA J MC KEOWN-LONGO; Fiscal Year: 2012
    ....
  11. Elucidating the JNK2-mediated redox regulation of cartilage matrix remdeling
    ELIZABETH ALICE ERICKSON; Fiscal Year: 2010
    ..The results of these studies could help in the identification of potential therapeutic targets that can slow or stop cartilage loss in osteoarthritis patients. ..
  12. Role of Meprin A in Acute Kidney Injury
    GUR PRASAD KAUSHAL; Fiscal Year: 2013
    ..In addition the study will identify meprin A-mediated urinary markers for early detection of AKI. Therefore, the proposal is clinically relevant to the VA patient population since a large segment of veterans suffer from AKI. ..
  13. PTH-RELATED PEPTIDE AND VIT D IN PROSTATE CANCER GROWTH
    Miriam Falzon; Fiscal Year: 2009
    ..abstract_text> ..
  14. Extracellular Matrix Remodeling During Aging
    JANE M SOTTILE; Fiscal Year: 2010
    ....
  15. Mechanism of Renal Cell Injury in Diabetes
    Goutam Ghosh Choudhury; Fiscal Year: 2013
    ....
  16. Jesse Roman; Fiscal Year: 2016
    ..If found to be causal, Eh Cys/CySS and nAChRs can be targeted for intervention in the hope of reducing the incidence and/or severity of HIV-related non-infectious lung disease. ..
  17. Bryon E Petersen; Fiscal Year: 2014
    ..This knowledge will help to guide the development of strategies for the therapeutic use of stem cell transplants for the treatment of liver disease. ..
  18. Recombinant Antibodies from the Sea Lamprey
    ZEEV contact PANCER; Fiscal Year: 2010
    ..search for alternatives to antibodies in the form of non-immunoglobulin (Ig) scaffolds such as ankyrin repeats, fibronectins, lipocalins and protein A...
  19. Meprin A Metalloproteinase in Acute Kidney Injury
    GUR PRASAD KAUSHAL; Fiscal Year: 2013
    ..The studies proposed in this application are aimed directly at understanding these mechanisms, which will result in appropriate therapeutic interventions. ..
  20. Edward K Chien; Fiscal Year: 2015
    ..Focusing on significant perinatal and long-term outcomes, we will bring to an end procedures and practices that are ineffective or incur undue risks. ..
  21. EXTRACELLULAR MATRIX IN INFLAMMATORY BOWEL DISEASE
    ALAN DAVID LEVINE; Fiscal Year: 2010
    ..Aim 2. Biochemical: Evaluate the specific protein serine kinases and target proteins modulated by the ligation of distinct integrin molecules in the migratory LPT, with a particular focus on vimentin. ..
  22. An angiogenic role for the alpha 5 beta 1 and alpha V beta 3 integrins during cer
    D RICHARD MILNER; Fiscal Year: 2012
    ..If successful, this work could have major impact on the incidence and mortality of ischemic stroke. ..
  23. Thrombospondins and other matricellular proteins in tissue organization and homeo
    Joanne E Murphy Ullrich; Fiscal Year: 2010
    ....
  24. Fibronectin-binding Protein of Treponema Denticola in Periodontal Disease
    Xiaoping Xu; Fiscal Year: 2012
    ..denticola to periodontal tissues and to characterize the biological function of the FbpA protein family in order to provide new strategies to prevent bacterial infections. ..
  25. Neutrophil Migration in Three Dimensions
    Jonathan S Reichner; Fiscal Year: 2013
    ..A 3D in vitro system that accounts for the salient mechanical features of organs and tissues will provide a better means to predict effectiveness of therapeutics indicated for control of inflammation. ..
  26. Role of influenza-induced prothrombosis in Streptococcus pyogenes superinfections
    Michael S Chaussee; Fiscal Year: 2012
    ..The results will be important in assessing, and mitigating with new treatment approaches, the morbidity and mortality associated with the flu. ..
  27. Identification of Mechanically Sensitive Proteins in Early Development
    Douglas W DeSimone; Fiscal Year: 2013
    ..These studies will contribute a catalog of candidate, mechanosensitive proteins that will comprise an important resource for investigators interested in the role of force in morphogenesis, normal tissue biology and disease. ..
  28. Matricellular Proteins in Trabecular Meshwork Increase Intraocular Pressure
    Douglas J Rhee; Fiscal Year: 2013
    ..The fundamental control of eye pressure is unknown. If successful, this project will reveal a previously unappreciated system leading to both a greater understanding of normal physiology and a potential avenue for treatment. ..
  29. CORNEAL LIPID METABOLISM AND RESPONSE TO INFLAMMATION
    Haydee E P Bazan; Fiscal Year: 2010
    ..If our hypothesis and its corollaries are correct, then PAF antagonists can become effective therapeutic tools for maintaining the transparency and integrity of the cornea. ..
  30. Dysregulated Pathways in Pulmonary Fibrosis
    Keith C Olsen; Fiscal Year: 2012
    ..This application seeks to improve the understanding of the disease and to identify possible therapeutic targets. ..
  31. Developing A Novel Therapy for Diabetic Retinopathy
    Danyang Chen; Fiscal Year: 2013
    ..The proposed studies will lay a solid groundwork for future Phase II preclinical studies of CLT-020 and this project may develop a more effective therapeutics to cure DR. ..
  32. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ....
  33. Molecular interactions: oral bacteria & matrix proteins
    Keith Mintz; Fiscal Year: 2010
    ..Understanding how bacteria interact with host cells or tissue constituents will aid in the development of novel therapeutics to prevent initiation or progression of the disease. ..
  34. PKD Family Kinase Function and Signaling in Lung Fibroblasts
    Hua Tang; Fiscal Year: 2012
    ..abstract_text> ..
  35. FIBRONECTIN REGULATION OF CARCINOMA APOPTOSIS
    Yvonne Kapila; Fiscal Year: 2009
    ..These studies will help explain some of the cell-matrix interactions and signaling mechanisms that regulate tumor cell biology, and may provide insights into the pathogenesis of oral SCC. ..
  36. Jeff Gross; Fiscal Year: 2016
    ..Identification of factors required for choroid fissure closure will have a direct impact on our understanding of coloboma formation and on the development of possible treatments. ..
  37. Sharon M Moe; Fiscal Year: 2015
    ..abstract_text> ..
  38. Anil Kumar Chauhan; Fiscal Year: 2016
    ....
  39. Renal Cell Response in Diabetes
    Hanna E Abboud; Fiscal Year: 2012
    ..It is our hope that identifying specific sources of oxygen radicals will allow targeted therapy to prevent diabetic nephropathy. ..
  40. Combinatorial Metal Oxide Substrates to Enhance Osteogenic Stem Cell Functions
    Jaime E Ramírez-Vick; Fiscal Year: 2012
    ....
  41. James P Nataro; Fiscal Year: 2014
    ..In this project, we will further characterize the mechanisms of EAEC- induced diarrhea with an eye toward development of effective preventive measures. ..
  42. HENRY BOOM; Fiscal Year: 2016
    ..Aim 3. To determine the ability of ManLAM to inhibit T cell responses to MTB in vivo using the murine MTB infection model and determining if there is variable sensitivity to ManLAM among humans. ..
  43. Directing Stem Cell Differentiation on Biologically Inspired Micropatterned Surfa
    Anita Shukla; Fiscal Year: 2012
    ....
  44. Sarah L Dallas; Fiscal Year: 2014
    ..As these studies will significantly advance our mechanistic understanding the process of bone formation, the research has implications for treatment of osteoporosis, osteogenesis imperfecta and metabolic bone diseases. ..
  45. Fibronectin Binding MSCRAMMs
    AXEL MAGNUS HOOK; Fiscal Year: 2013
    ..Many microorganisms require Fn-binding proteins to be fully infectious. We propose to characterize the microbe-Fn interaction in detail and to determine the molecular basis for the role of Fn-binding proteins in infectious disease. ..
  46. Modulators of Fibronectin Fibrillogenesis
    BIANCA RAQUEL TOMASINI-JOHANSSON; Fiscal Year: 2012
    ..We are interested in developing assays that will measure fibronectin fibril formation, with the idea that compounds that modify fibronectin fibril formation may eventually be useful in therapies for fibrotic diseases and cancer. ..
  47. BARRY FANBURG; Fiscal Year: 2015
    ..We hope to better define any role of SERT, TGase activity and protein serotonylation in the development of PH and to consider possible new interventional strategies through these pathways that might be used for treating this disease. ..
  48. Richard Steet; Fiscal Year: 2016
    ..abstract_text> ..
  49. Human Myocardium Engineered Using Developmentally-Inspired Protein Scaffolds
    ADAM WALTER FEINBERG; Fiscal Year: 2012
    ..This will enable us to tissue engineering 3-D human cardiac tissues, which will have future application in heart repair. ..
  50. BMP Regulation of TGF-b2 in the Trabecular Meshwork
    Robert J Wordinger; Fiscal Year: 2012
    ..This study is relevant because it will examine the role of local growth factors in the control of eye pressure and may lead to new treatments for glaucoma. ..
  51. Keith Burridge; Fiscal Year: 2016
    ..Finally, we will explore the role of RhoGDI in mediating the trafficking of Rho proteins from their sites of postranslational modification to their sites of action at the plasma membrane. ..
  52. Jesse Roman; Fiscal Year: 2016
    ....
  53. Molecular regulation of breast cancer growth
    Marsha A Moses; Fiscal Year: 2010
    ....
  54. FASEB SRC on Matricellular Proteins in Development, Health, and Disease
    Joanne E Murphy-Ullrich; Fiscal Year: 2013
    ....
  55. W Matthew Petroll; Fiscal Year: 2016
    ..During the course of the grant, training will be provided to a total of two biomedical engineering graduate (PhD) students, two post-docs, as well as 4 summer medical students and 3 undergraduate research fellows. ..
  56. Regulation of call adhesion in Xenopus
    KEN CHO; Fiscal Year: 2009
    ..As the development of tumors often parallels the process of embryonic development in terms of rapid cell proliferation and extensive cellular movements, our work may provide direct relevance for a better understanding of tumorigenesis. ..
  57. Effects of Shear on Specific Adhesion Receptor Expression and Binding in the Bact
    James D Bryers; Fiscal Year: 2010
    ..2. Quantify the kinetics of FNBR adhesin receptor expression on SE surfaces, as function of bacterial growth condition and prevailing fluid shear;both as planktonic and adherent cells. ..
  58. Aging related susceptibility to lung injury - remodeling and oxidative stress
    Jesse Roman; Fiscal Year: 2012
    ....
  59. An Intracellular Niche for Borrelia burgdorferi
    Jonathan T Skare; Fiscal Year: 2013
    ..The overall goal of these studies is to determine the extent in which an intracellula locale contributes to borrelial persistence. ..
  60. Jun Lin Guan; Fiscal Year: 2014
    ..examine the role and mechanisms of elevated immune cell infiltration in the suppression of mammary tumor development upon FIP200 ablation, and 3). investigate the potential role of FIP200 in mammary tumor maintenance. ..
  61. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  62. Rebecca G Wells; Fiscal Year: 2016
    ..determine the role of three central groups of matrix proteins - cross-linked collagens and elastins, cellular fibronectins, and small leucine-rich proteoglycans - in these processe...
  63. Neutrophil-epithelial interaction mediated by adenosine
    Didier Merlin; Fiscal Year: 2013
    ..abstract_text> ..
  64. FIBRONECTIN RECEPTOR IN CANDIDA TROPICALIS
    MARGARET HOSTETTER; Fiscal Year: 2003
    ..The surface protein(s) identified in C. tropicalis should enable us to develop innovative preventive and therapeutic modalities to address two species that account for more than 75 percent of candidal infections. ..
  65. FIBRONECTIN--PROTEOGLYCAN BINDING IN ADHESION SITES
    LLOYD CULP; Fiscal Year: 1993
    ....
  66. FIBRONECTIN RECEPTOR MEDIATED ADHESION OF P GINGIVALIS
    KAREN SNAPP; Fiscal Year: 1993
    ..gingivalis and oral epithelium. Importantly, the ability to use an established cell line as an in vitro model for bacterial adhesion in the oral cavity will also be investigated...
  67. EXTRACELLULAR MATRIX ASSEMBLY OF FIBRONECTIN
    Jane Sottile; Fiscal Year: 1999
    ....
  68. PLASMA FIBRONECTIN AND LUNG VASCULAR PERMEABILITY
    THOMAS SABA; Fiscal Year: 2000
    ....
  69. Forces at the heart of Staphylococcus biofilms on cardiac implants
    STEVEN LOWER; Fiscal Year: 2009
    ..Our preliminary work suggests that the "force taxonomy" of S. aureus may provide a fundamental yet practical indicator of pathogen-related risk for patients considering prosthetic device implants. ..
  70. ANGIOGENESIS INHIBITORS: A MECHANISM OF ACTION
    Erkki Ruoslahti; Fiscal Year: 2006
    ..This study may provide important information on the mechanism of action of a class of angiogenesis inhibitors, information that may prove helpful in designing clinical trials for these compounds. [unreadable] [unreadable]..
  71. DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINS
    SARAH DALLAS; Fiscal Year: 2009
    ..abstract_text> ..
  72. REGULATION OF FIBRONECTIN MATRIX ASSEMBLY
    PAULA MC KEOWN LONGO; Fiscal Year: 1991
    ..The regulation of 18K protein function may have important implications in morphogenesis (e.g. cell migration and differentiation) and pathological processes such as fibrosis and tumor cell metastasis...
  73. CORNEAL HEALING PROMOTION WITH FIBRONECTIN PEPTIDES
    LEO FURCHT; Fiscal Year: 1990
    ..This would also have application for diseases of the eye where there is abnormal wound healing. Modest success in this research program could have a major impact on serious health care problems...
  74. INTEGRIN A5B1 AND TUMOR CELL GROWTH
    Judith Varner; Fiscal Year: 2000
    ..By obtaining an understanding of the mechanisms by which this and other integrins can regulate cellular growth, it may ultimately be possible to develop strategies to control the growth of tumors. ..