hepatitis c antibodies

Summary

Summary: Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.

Top Publications

  1. pmc Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission
    Claire L Brimacombe
    Hepatitis C Research Group, Institute for Biomedical Research, University of Birmingham, Vincent Drive, Birmingham B15 2TT, United Kingdom
    J Virol 85:596-605. 2011
  2. ncbi Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo
    Thomas von Hahn
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10021, USA
    Gastroenterology 132:667-78. 2007
  3. pmc Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation
    Samira Fafi-Kremer
    Institut National de la Sante et de la Recherche Medicale, Unité 748, Strasbourg, France
    J Exp Med 207:2019-31. 2010
  4. pmc Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus
    Teresa J Broering
    MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts 02130, USA
    J Virol 83:12473-82. 2009
  5. pmc Anti-C1q antibodies in hepatitis C virus infection
    D Saadoun
    Service de Medecine Interne, Hopital Pitie Salpetriere, 83 Boulevard de l hopital, 75651 Cedex 13 Paris, France
    Clin Exp Immunol 145:308-12. 2006
  6. pmc Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
    Mayla Hsu
    Aaron Diamond AIDS Research Center and Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:7271-6. 2003
  7. ncbi Epidemiology of hepatitis C virus in Korea
    Hai Rim Shin
    Division of Cancer Control and Epidemiology, National Cancer Center, 809 Madu dong, Ilsan gu, Goyang, Gyeonggi do 411 769, Korea
    Intervirology 49:18-22. 2006
  8. ncbi Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance
    J Tilman Gerlach
    Medical Department II, Klinikum Grosshadern and Institute for Immunology, Schwabing, Munich, Germany
    Gastroenterology 125:80-8. 2003
  9. pmc Spontaneous clearance of chronic hepatitis C virus infection is associated with appearance of neutralizing antibodies and reversal of T-cell exhaustion
    Sukanya Raghuraman
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health, Department of Health and Human Services DHHS, Bethesda, MD, USA
    J Infect Dis 205:763-71. 2012
  10. pmc In vitro assay for neutralizing antibody to hepatitis C virus: evidence for broadly conserved neutralization epitopes
    Birke Bartosch
    Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, Institut National de la Santé et de la Recherche Médicale U412, IFR 128, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Proc Natl Acad Sci U S A 100:14199-204. 2003

Detail Information

Publications263 found, 100 shown here

  1. pmc Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission
    Claire L Brimacombe
    Hepatitis C Research Group, Institute for Biomedical Research, University of Birmingham, Vincent Drive, Birmingham B15 2TT, United Kingdom
    J Virol 85:596-605. 2011
    ..These observations highlight the importance of targeting host cell receptors, in particular SR-BI, to control viral infection and spread in the liver...
  2. ncbi Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo
    Thomas von Hahn
    Center for the Study of Hepatitis C, The Rockefeller University, New York, New York 10021, USA
    Gastroenterology 132:667-78. 2007
    ....
  3. pmc Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation
    Samira Fafi-Kremer
    Institut National de la Sante et de la Recherche Medicale, Unité 748, Strasbourg, France
    J Exp Med 207:2019-31. 2010
    ..These findings provide significant insights into the molecular mechanisms of viral evasion during HCV reinfection and suggest that viral entry is a viable target for prevention of HCV reinfection of the liver graft...
  4. pmc Identification and characterization of broadly neutralizing human monoclonal antibodies directed against the E2 envelope glycoprotein of hepatitis C virus
    Teresa J Broering
    MassBiologics, University of Massachusetts Medical School, Boston, Massachusetts 02130, USA
    J Virol 83:12473-82. 2009
    ....
  5. pmc Anti-C1q antibodies in hepatitis C virus infection
    D Saadoun
    Service de Medecine Interne, Hopital Pitie Salpetriere, 83 Boulevard de l hopital, 75651 Cedex 13 Paris, France
    Clin Exp Immunol 145:308-12. 2006
    ..Anti-C1q antibodies were associated with low C4 levels. No association was found between anti-C1q antibodies and HCV-MC vasculitis, nor between anti-C1q antibodies and cryoglobulinaemia...
  6. pmc Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
    Mayla Hsu
    Aaron Diamond AIDS Research Center and Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:7271-6. 2003
    ..However, HIV-HCV pseudotype infectivity was inhibited by a recombinant soluble form of CD81 and a mAb specific for CD81, suggesting that CD81 may be a component of a receptor complex...
  7. ncbi Epidemiology of hepatitis C virus in Korea
    Hai Rim Shin
    Division of Cancer Control and Epidemiology, National Cancer Center, 809 Madu dong, Ilsan gu, Goyang, Gyeonggi do 411 769, Korea
    Intervirology 49:18-22. 2006
    ..Moreover, most people infected with HCV in Korea are older than 40 years, and therefore, the surveillance of adults (> or =40 years) for HCV infection will be helpful in early detection of HCC developing in them...
  8. ncbi Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance
    J Tilman Gerlach
    Medical Department II, Klinikum Grosshadern and Institute for Immunology, Schwabing, Munich, Germany
    Gastroenterology 125:80-8. 2003
    ..The aim of this study was to define the natural course of the disease and to contribute to the development of treatment strategies for acute hepatitis C virus...
  9. pmc Spontaneous clearance of chronic hepatitis C virus infection is associated with appearance of neutralizing antibodies and reversal of T-cell exhaustion
    Sukanya Raghuraman
    Immunology Section, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIDDK, National Institutes of Health, Department of Health and Human Services DHHS, Bethesda, MD, USA
    J Infect Dis 205:763-71. 2012
    ..Spontaneous recovery from chronic infection is rare and has never to our knowledge been studied immunologically...
  10. pmc In vitro assay for neutralizing antibody to hepatitis C virus: evidence for broadly conserved neutralization epitopes
    Birke Bartosch
    Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, Institut National de la Santé et de la Recherche Médicale U412, IFR 128, Ecole Normale Superieure de Lyon, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Proc Natl Acad Sci U S A 100:14199-204. 2003
    ..The ability to assay neutralizing anti-HCV should permit an assessment of the prospects for successful Ab-mediated passive and active immunoprophylaxis against hepatitis C...
  11. pmc Identification of a broadly cross-reacting and neutralizing human monoclonal antibody directed against the hepatitis C virus E2 protein
    Mario Perotti
    Laboratorio di Microbiologia e Virologia, Universita Vita Salute San Raffaele, DIBIT2, Via Olgettina 60, 20132 Milano, Italia
    J Virol 82:1047-52. 2008
    ..Fab e137 was also able to inhibit cell culture-grown HCV (genotype 2a). These data indicate that broadly cross-reacting and cross-neutralizing antibodies are generated during HCV infection...
  12. ncbi Hepatitis B and C virus infection in Nigerian patients with HIV/AIDS
    O A Lesi
    Department of Medicine, College of Medicine, University of Lagos, PMB 12003, Idi Araba, Lagos
    Niger Postgrad Med J 14:129-33. 2007
    ..This study was designed to assess the prevalence of HBV and HCV infection in HIV patients and evaluate the risk of infection compared with HIV negative control subjects...
  13. ncbi Simultaneous determination of HIV antibodies, hepatitis C antibodies, and hepatitis B antigens in dried blood spots--a feasibility study using a multi-analyte immunoassay
    Zoltan Lukacs
    Department of Pediatrics, Metabolic Laboratory, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Chem Lab Med 43:141-5. 2005
    ..We demonstrated the feasibility of the simultaneous detection of infectious diseases from dried blood. Our novel method also provides a convenient tool for monitoring children from HIV-positive mothers and for possible screening efforts...
  14. ncbi Evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus
    Bryce D Smith
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 204:825-31. 2011
    ..Although therapies are available that can suppress or eliminate infection, identifying persons infected with HCV is challenging. Rapid tests could help identify many of these persons more expeditiously...
  15. pmc Noninvasive assessment of hepatic fibrosis in Egyptian patients with chronic hepatitis C virus infection
    Shawky Abdelhamid Fouad
    Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo 11562, Egypt
    World J Gastroenterol 18:2988-94. 2012
    ..To evaluate the accuracy of specific biochemical markers for the assessment of hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection...
  16. pmc Incidence and risk factors for community-acquired hepatitis C infection from birth to 5 years of age in rural Egyptian children
    Doa a A Saleh
    Department of Community Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
    Trans R Soc Trop Med Hyg 104:357-63. 2010
    ..The virus cleared in six (40%) children by the end of follow-up. Health education targeting iatrogenic exposures and focusing on risk factors could reduce HCV infection in children in high-risk populations...
  17. pmc Both innate and adaptive immunity mediate protective immunity against hepatitis C virus infection in chimpanzees
    Heidi Barth
    Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA
    Hepatology 54:1135-48. 2011
    ..Furthermore, our results suggest that serum neutralizing antibodies may contribute to early control of viral replication and spread after homologous HCV rechallenges but may not be sufficient for a long-term protective immunity...
  18. ncbi Is it possible to diagnose acute hepatitis C virus (HCV) infection by a rising anti-HCV titre rather than by seroconversion?
    S N Lu
    Division of Hepato Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Niaosung, Kaohsiung, Taiwan
    J Viral Hepat 11:563-70. 2004
    ..The rise in S/CO ratios using a third generation anti-HCV assay and the RIBA pattern might be used as a supplemental diagnostic criterion for acute HCV infection...
  19. pmc Monoclonal antibody AP33 defines a broadly neutralizing epitope on the hepatitis C virus E2 envelope glycoprotein
    Ania Owsianka
    MRC Virology Unit, Institute of Virology, University of Glasgow, UK
    J Virol 79:11095-104. 2005
    ..Thus, identification of a broadly neutralizing antibody that recognizes a linear epitope is likely to be of significant benefit to future vaccine and therapeutic antibody development...
  20. pmc The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein
    François Helle
    Institut de Biologie de Lille UMR8161, CNRS, Université Lille I and II and Institut Pasteur de Lille, Lille, France
    J Virol 81:8101-11. 2007
    ..In conclusion, this work indicates that HCV glycans contribute to the evasion of HCV from the humoral immune response...
  21. pmc Temporal trends in hepatitis B and C infection in family blood donors from interior Sindh, Pakistan
    Syed Abdul Mujeeb
    Jinnah Postgraduate Medical Centre, Karachi, Pakistan
    BMC Infect Dis 8:43. 2008
    ..Pakistan has no active surveillance program to monitor trends of these infections. The objective of this study was to verify this trend in blood donors from the rural Sindh area of the country...
  22. ncbi Natural history of chronic hepatitis B REVEALed
    Chien Jen Chen
    Genomics Research Center, Academia Sinica, National Taiwan University, Taipei, Taichung, Taiwan
    J Gastroenterol Hepatol 26:628-38. 2011
    ..Serum HBV DNA level at study entry is a major predictor of spontaneous seroclearance of HBeAg, HBV DNA and HBsAg. These findings may inform the effective and efficient management of chronic hepatitis B...
  23. ncbi Seroprevalence of hepatitis B and C viruses among HIV-infected pregnant women in Uganda and Rwanda
    Maria F Pirillo
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
    J Med Virol 79:1797-801. 2007
    ....
  24. pmc Characterization of low- and very-low-density hepatitis C virus RNA-containing particles
    P Andre
    INSERM U503, CERVI, Lyon, France
    J Virol 76:6919-28. 2002
    ..These results suggest that the infectivity of LVP is mediated by endogenous proteins rather than by viral components providing a mechanism of escape from the humoral immune response...
  25. ncbi Increased rate of death related to presence of viremia among hepatitis C virus antibody-positive subjects in a community-based cohort study
    Hirofumi Uto
    Department of Digestive and Life style Related Disease, Health Research Human and Environmental Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Hepatology 50:393-9. 2009
    ..Among HCV carriers, a higher level of HCVcAg (>or=100 pg/mL) and persistently elevated alanine aminotransferase levels were important predictors of liver-related mortality...
  26. ncbi Prevalence of occult hepatitis B and hepatitis C virus infections in Turkish hemodialysis patients
    Fahri Yakaryilmaz
    Faculty of Medicine, Department of Gastroenterology, Kirikkale University, Kirikkale, Turkey
    Ren Fail 28:729-35. 2006
    ..This study aimed to determine the prevalence of occult HBV and HCV infections in maintenance hemodialysis patients...
  27. ncbi High density lipoprotein inhibits hepatitis C virus-neutralizing antibodies by stimulating cell entry via activation of the scavenger receptor BI
    Marlene Dreux
    INSERM, U758, 69007 Lyon, France
    J Biol Chem 281:18285-95. 2006
    ..Consistently, we show that antibodies targeted to HCV-E1 efficiently neutralize HCVpp and HCVcc in the presence of human serum...
  28. ncbi Association of diabetes mellitus and chronic hepatitis C virus infection
    A L Mason
    Section of Gastroenterology and Hepatology, Alton Ochsner Medical Institutions, New Orleans, LA, USA
    Hepatology 29:328-33. 1999
    ..Furthermore, it is possible that HCV infection may serve as an additional risk factor for the development of diabetes, beyond that attributable to chronic liver disease alone...
  29. pmc In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus
    Philip Meuleman
    Center for Vaccinology, Ghent University and Hospital, Ghent, Belgium
    Hepatology 53:755-62. 2011
    ..Animals in which the antibody pretreatment failed displayed a clear delay in the kinetics of viral infection. Sequence analysis of the recovered viruses did not suggest antibody-induced viral escape...
  30. ncbi HBV and HCV prevalence and viraemia in HIV-positive and HIV-negative pregnant women in Abidjan, Côte d'Ivoire: the ANRS 1236 study
    Francois Rouet
    CeDReS, Programme PAC CI, CHU de Treichville, Abidjan, Ivory Coast
    J Med Virol 74:34-40. 2004
    ..We propose an accurate and cost-efficient algorithm for HCV diagnosis in Africa...
  31. pmc Worldwide variation in the relative importance of hepatitis B and hepatitis C viruses in hepatocellular carcinoma: a systematic review
    S A Raza
    Department of Surgery, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    Br J Cancer 96:1127-34. 2007
    ..A predominance of HBsAg was found in HCCs from most Asian, African and Latin American countries, but anti-HCV predominated in Japan, Pakistan, Mongolia and Egypt. Anti-HCV was found more often than HBsAg in Europe and the United States...
  32. ncbi Hepatitis C and progression of HIV disease
    Mark S Sulkowski
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E Monument St, Room 448, Baltimore, MD 21287 0003, USA
    JAMA 288:199-206. 2002
    ..Conflicting reports exist regarding the effect of hepatitis C virus (HCV) on the progression of human immunodeficiency virus (HIV) disease...
  33. pmc Analysis of successful immune responses in persons infected with hepatitis C virus
    F Lechner
    Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Exp Med 191:1499-512. 2000
    ..These studies demonstrate a strong and persistent CTL response in resolving acute HCV infection, and provide rationale to explore immune augmentation as a therapeutic intervention in chronic HCV infection...
  34. ncbi Peginterferon Alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV-infected patients
    Francesca J Torriani
    Department of Medicine, Division of Infectious Diseases, University of California, San Diego, Antiviral Research Center, CA 92103, USA
    N Engl J Med 351:438-50. 2004
    ....
  35. ncbi Prevalence of hepatitis B and C serological markers among first-time blood donors in Brazil: a multi-center serosurvey
    Maria Claudia Nascimento
    Laboratório de Virologia do Instituto de Medicina Tropical, Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Med Virol 80:53-7. 2008
    ..95; 95% CI: 1.2-3.1), but not women. The seroprevalence of HBV and HCV was low among Brazilian blood donors, and exposure increased with age in both genders...
  36. ncbi Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown
    Inmaculada Castillo
    Fundacion para el Estudio de las Hepatitis Virales, Clinica Puerta de Hierro, Madrid, Spain
    J Infect Dis 189:7-14. 2004
    ..We analyzed the presence of hepatitis C virus (HCV) RNA in liver-biopsy specimens from 100 patients who were negative for anti-HCV antibodies and for serum HCV RNA and who had ALF-EU...
  37. ncbi Seroprevalence of the antibody to hepatitis C in select groups in the Punjab region of Pakistan
    M Aslam
    Punjab Hepatitis Research Center, Lahore, Pakistan
    J Clin Gastroenterol 33:407-11. 2001
    ..This may indicate the likelihood of a relationship between the high rate of hepatitis C and the administration of the smallpox vaccine in Pakistan...
  38. ncbi Distribution of hepatitis C virus genotypes among blood donors from mid-west region of Brazil
    Regina M B Martins
    Instituto de Patologia Tropical e Saude Publica, Universidade Federal de Goias, Goiania, GO, Brazil
    Rev Inst Med Trop Sao Paulo 48:53-5. 2006
    ..8%), followed by 3a (21.1%). Subtype 2b was rare (2.4%, 4.5% and 5.3%, respectively). In Distrito Federal, subtype 3a (39%) was more frequent than 1a (31.7%) and the remaining (29.3%) belonged to subtype 1b...
  39. pmc Hepatitis C virus evasion mechanisms from neutralizing antibodies
    Caterina Di Lorenzo
    MRC University of Glasgow Centre for Virus Research, Glasgow, G11 5JR, UK
    Viruses 3:2280-300. 2011
    ..This review summarizes the current knowledge of the mechanisms used by HCV to evade host neutralizing antibodies...
  40. ncbi Performance of premarket rapid hepatitis C virus antibody assays in 4 national human immunodeficiency virus behavioral surveillance system sites
    Bryce D Smith
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 53:780-6. 2011
    ..The highest assay-specific sensitivities achieved for the Chembio, MedMira and OraSure tests were 94.0%, 78.9%, and 97.4%, respectively; the highest specificities were 97.7%, 83.3%, and 100%, respectively...
  41. pmc Characterization of antibodies induced by vaccination with hepatitis C virus envelope glycoproteins
    Ranjit Ray
    Department of Internal Medicine and Vaccine and Treatment Evaluation Unit, Saint Louis University, St Louis, Missouri, USA
    J Infect Dis 202:862-6. 2010
    ..Neutralizing serum samples had increased affinity levels and displayed >2-fold higher specific activity levels to well-characterized epitopes on E1/E2, especially to the hypervariable region 1 of E2...
  42. ncbi Low risk for hepatitis C seroconversion in methadone maintenance treatment
    Einat Peles
    Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel
    J Addict Med 5:214-20. 2011
    ..To study the risk factors for seroconversion to hepatitis C virus (HCV) infection since admission to methadone maintenance treatment (MMT) and to characterize the seronegative admitted group...
  43. ncbi Field-based performance of three pre-market rapid hepatitis C virus antibody assays in STAHR (Study to Assess Hepatitis C Risk) among young adults who inject drugs in San Diego, CA
    A Jewett
    Oak Ridge Institute for Science and Education, Clinton, TN, USA
    J Clin Virol 54:213-7. 2012
    ..Persons who inject drugs (PWID) account for 55.8% of all persons with HCV antibody (anti-HCV) in the U.S. PWID have limited access to healthcare and are infrequently tested for anti-HCV using conventional laboratory assays...
  44. ncbi Acute hepatitis C in Korea: different modes of infection, high rate of spontaneous recovery, and low rate of seroconversion
    Jong Yeop Kim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Bundang, Korea
    J Med Virol 83:1195-202. 2011
    ..The characteristics of acute hepatitis C in Asian countries warrants further study...
  45. pmc Incidence of hepatitis C virus infection among injection drug users during an outbreak of HIV infection
    D M Patrick
    University of British Columbia Centre for Disease Control, University of British Columbia, Vancouver, BC
    CMAJ 165:889-95. 2001
    ..The objectives of this study were to measure the prevalence and incidence of hepatitis C virus (HCV) infection in this context and to examine factors associated with HCV seroconversion among IDUs...
  46. pmc Complement-mediated enhancement of antibody function for neutralization of pseudotype virus containing hepatitis C virus E2 chimeric glycoprotein
    Keith Meyer
    Department of Internal Medicine, Saint Louis University, 3635 Vista Ave, St Louis, Missouri 63110, USA
    J Virol 76:2150-8. 2002
    ....
  47. ncbi Determination of the human antibody response to the epitope defined by the hepatitis C virus-neutralizing monoclonal antibody AP33
    Alexander W Tarr
    The Institute of Infection, Immunity and Inflammation and Division of Microbiology, The University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Gen Virol 88:2991-3001. 2007
    ..Importantly, individuals harbouring AP33-like antibodies are an important potential source of human mAbs for future therapeutic development...
  48. pmc Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: genetic subtype defines antigenic but not neutralization serotype
    Alexander W Tarr
    School of Molecular Medical Sciences, The University of Nottingham, A Floor West Block, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Virol 85:4246-57. 2011
    ....
  49. ncbi Clinical utility and characteristics of nine anti-HCV antibody screening reagents used in Japan
    Mifumi Kita
    Department of Clinical Laboratory, Otemae Hospital, Osaka, Japan
    Clin Lab 55:9-22. 2009
    ..Each anti-HCV antibody screening reagent in use has unique features, and it is suggested that caution be used when diagnosing HCV infection on the basis of the results of a single antibody test...
  50. pmc Acceleration of hepatitis C virus envelope evolution in humans is consistent with progressive humoral immune selection during the transition from acute to chronic infection
    Lin Liu
    Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, 855 N Wolfe St, Suite 530, Baltimore, MD 21205, USA
    J Virol 84:5067-77. 2010
    ..These data provide the first systematic estimates of HCV evolutionary rates in multiple genes during early infection in vivo and provide additional evidence for deterministic, rather than random, evolution of HCV...
  51. ncbi Multicenter evaluation of a fully automated third-generation anti-HCV antibody screening test with excellent sensitivity and specificity
    F Alborino
    Ospedale di Dolo, Servizio di Medicina di Laboratorio, Dolo, Italy
    Med Microbiol Immunol 200:77-83. 2011
    ..5% (39/40). Overall, the performance of the Elecsys Anti-HCV assay was similar to the performances of the comparator CE-marked Anti-HCV antibody assays...
  52. ncbi Risk factors of hepatitis C infection among Egyptian blood donors
    Hala Ibrahim Awadalla
    Institute of Environmental Studies and Research, Ain Shams University, Cairo, Egypt
    Cent Eur J Public Health 19:217-21. 2011
    ..Surveillance of infectious disease markers in the blood donor population is important in recognizing trends in prevalence and incidence of transfusion related infections in asymptomatic volunteer blood donors...
  53. ncbi Hepatitis C virus reinfection in injection drug users
    Jason Grebely
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Hepatology 44:1139-45. 2006
    ..23; 95% CI, 0.10-0.51, P < .001). In conclusion, individuals with clearance of HCV infection may have a lower risk of acquiring HCV than individuals who have never been infected, despite ongoing exposure to HCV...
  54. ncbi Decreased prevalence and incidence of HCV markers in haemodialysis units: a multicentric French survey
    Karine Saune
    INSERM U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    Nephrol Dial Transplant 26:2309-16. 2011
    ..We conducted a multicentric study to determine the prevalence and incidence of HCV infection in French haemodialysis units...
  55. ncbi Induction of neutralizing antibody responses to hepatitis C virus with synthetic peptide constructs incorporating both antibody and T-helper epitopes
    Joseph Torresi
    Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia
    Immunol Cell Biol 85:169-73. 2007
    ..These results demonstrate the potential of synthetic peptide-based constructs in the delivery of potential neutralizing epitopes that are present within the viral envelope of HCV...
  56. pmc Multispecific T cell response and negative HCV RNA tests during acute HCV infection are early prognostic factors of spontaneous clearance
    E Spada
    Istituto Superiore di Sanita, National Center of Epidemiology, Surveillance and Health Promotion, Clinical Epidemiology Unit, Viale Regina Elena 299, 00161 Rome, Italy
    Gut 53:1673-81. 2004
    ..The aim of this study was to identify early prognostic markers of disease resolution by performing a comprehensive analysis of viral and host factors during the natural course of acute HCV infection...
  57. pmc Clinical performance evaluation of four automated chemiluminescence immunoassays for hepatitis C virus antibody detection
    Sinyoung Kim
    Department of Laboratory Medicine, Yonsei University College of Medicine, Seodaemun gu, Seoul, Korea
    J Clin Microbiol 46:3919-23. 2008
    ..1%. The clinical sensitivity of all CLIAs was 100%. Each CLIA showed excellent reproducibility and clinical sensitivity. The Elecsys, Architect, Vitros, and Access CLIAs showed clinical specificities of 98.2, 98.8, 96.5, and 98.2%...
  58. pmc Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection
    William O Osburn
    Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Gastroenterology 138:315-24. 2010
    ..We followed patients with ongoing hepatitis C virus (HCV) exposure following control of an initial HCV infection to determine whether primary control conferred protection against future persistent infections...
  59. ncbi Gender differences in hepatitis C antibody prevalence and risk behaviours amongst people who inject drugs in Australia 1998-2008
    Jenny Iversen
    Viral Hepatitis Epidemiology and Prevention Program, National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Australia
    Int J Drug Policy 21:471-6. 2010
    ..This study aims to assess gender differences in hepatitis C antibody prevalence and associated risk behaviours amongst a large sample of PWID in Australia...
  60. ncbi Susceptibility to thyroid disorders in hepatitis C
    Luigi Muratori
    Department of Internal Medicine, Cardioangiology, Hepatology, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Clin Gastroenterol Hepatol 3:595-603. 2005
    ..We wondered whether seropositivity for NOSA is associated with susceptibility to AITDs...
  61. ncbi Routine HCV PCR screening of blood donations to identify early HCV infection in blood donors lacking antibodies to HCV
    W E Hitzler
    Transfusion Center, Johannes Gutenberg Clinic, University of Mainz, Mainz, Germany
    Transfusion 41:333-7. 2001
    ..The often mild symptoms of acute hepatitis C also cause difficulties in the identification of early HCV infection. The feasibility and efficacy of routine screening of blood donations for HCV RNA were investigated...
  62. ncbi Serum antibodies against the hepatitis C virus E2 protein mediate antibody-dependent cellular cytotoxicity (ADCC)
    Jacob Nattermann
    Department of General Internal Medicine I, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Hepatol 42:499-504. 2005
    ..Antibodies mediating ADCC are usually directed against viral envelope proteins. As cell surface expression of the HCV envelope E2 protein has been shown, the HCV E2 protein is an especially promising candidate target for ADCC...
  63. ncbi Chronic hepatitis C virus and celiac disease, is there an association?
    Lincoln Hernandez
    Department of Medicine, Columbia University College of Physicians and Surgeons, Harkness Pavilion 956, New York, NY 10032, USA
    Dig Dis Sci 53:256-61. 2008
    ..CD prevalence is not increased in patients with HCV. Routine screening of CD in HCV patients is not warranted, however, the presence of CD should be considered in the setting of clinical deterioration during or after IFN-alpha therapy...
  64. ncbi Prevalence and correlates of hepatitis C virus infection among injecting drug users in Tehran
    Saman Zamani
    Department of Global Health and Socio Epidemiology, Kyoto University School of Public Health, Kyoto, Japan
    Int J Drug Policy 18:359-63. 2007
    ..While prevention interventions for drug using inmates are being expanded in Iran, it is important that high prevalence of HCV infection be taken into consideration in order to control further transmission of this infection...
  65. ncbi Neutralizing host responses in hepatitis C virus infection target viral entry at postbinding steps and membrane fusion
    Anita Haberstroh
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Gastroenterology 135:1719-1728.e1. 2008
    ..Retroviral HCV pseudotypes (HCVpp) and recombinant cell culture-derived HCV (HCVcc) have been successfully used to study viral entry and antibody-mediated neutralization...
  66. pmc Immunogenic and functional organization of hepatitis C virus (HCV) glycoprotein E2 on infectious HCV virions
    Zhen Yong Keck
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Virol 81:1043-7. 2007
    ..Collectively, these findings support an immunogenic model of HCV E2 having three immunogenic domains with distinct structures and functions and provide added support for the idea that CD81 is required for virus entry...
  67. pmc Prevalence of antibodies to hepatitis C virus in apparently healthy Port Harcourt blood donors and association with blood groups and other risk indicators
    Zaccheaus Awortu Jeremiah
    Dept of Medical Laboratory Sciences, Niger Delta University, Wilberforce Island, Bayelsa State
    Blood Transfus 6:150-5. 2008
    ..The aim of this study was to determine the prevalence of HCV among apparently healthy blood donors in our area and also to assess some of the risk factors associated with the infection...
  68. ncbi Characterization of humoral and cell-mediated immune responses directed against hepatitis C virus F protein in subjects co-infected with hepatitis C virus and HIV-1
    Myriam Troesch
    Unité d Immunopathologie Virale, Centre de Recherche, Hopital Sainte Justine, Montreal, Quebec, Canada
    AIDS 19:775-84. 2005
    ..This study was conducted to examine the prevalence and characteristics of host humoral and cell-mediated immune responses directed against F protein in patients co-infected with HCV and HIV-1...
  69. pmc Automated RIBA hepatitis C virus (HCV) strip immunoblot assay for reproducible HCV diagnosis
    P Martin
    Department of Medicine, School of Medicine, University of California at Los Angeles, 90024 1749, USA
    J Clin Microbiol 36:387-90. 1998
    ..Our data indicate that this novel methodology may be very useful for supplemental anti-HCV testing of specimens repeatedly reactive by ELISA in routine clinical assessments and epidemiologic evaluations...
  70. pmc Prospective follow-up of patients with acute hepatitis C virus infection in Brazil
    Lia L Lewis-Ximenez
    Viral Hepatitis Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil
    Clin Infect Dis 50:1222-30. 2010
    ..The natural outcome of infection with hepatitis C virus (HCV) varies substantially among individuals. However, little is known about host and viral factors associated with a self-limiting or chronic evolution of HCV infection...
  71. ncbi The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
    P Farci
    Department of Medical Sciences, University of Cagliari, Via San Giorgio 12, 09124 Cagliari, Italy
    Science 288:339-44. 2000
    ..These data indicate that the evolutionary dynamics of the HCV quasispecies during the acute phase of hepatitis C predict whether the infection will resolve or become chronic...
  72. pmc Neutralizing antibodies to hepatitis C virus (HCV) in immune globulins derived from anti-HCV-positive plasma
    Mei Ying W Yu
    Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, 29 Lincoln Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:7705-10. 2004
    ..Immune globulins made from anti-HCV-positive plasma and containing broadly reactive neutralizing antibodies may provide a method of preventing HCV infection...
  73. ncbi Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies
    Zania Stamataki
    University of Birmingham, Division of Immunity and Infection, Birmingham, UK
    Vaccine 25:7773-84. 2007
    ..These data demonstrate that recombinant E2 and E1E2 can induce polyclonal antibody responses with cross-reactive neutralizing activity, supporting the future development of prophylactic and therapeutic vaccines...
  74. pmc Cellular immune responses in seronegative sexual contacts of acute hepatitis C patients
    Sanaa M Kamal
    Department of Infectious Diseases, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    J Virol 78:12252-8. 2004
    ..This finding has important implications for HCV vaccine and therapeutic development...
  75. ncbi Epidemiology of hepatitis C virus infection in seven European Union countries: a critical analysis of the literature. HENCORE Group. (Hepatitis C European Network for Co-operative Research
    S Touzet
    Département d information médicale, Hospices Civils de Lyon, France
    Eur J Gastroenterol Hepatol 12:667-78. 2000
    ..Multicentre studies conducted in larger samples are needed to obtain more accurate and reliable results, in particular. However, the epidemiological studies available allowed us to assess the magnitude of HCV infection in Europe...
  76. ncbi Payment for whole blood donations in Lithuania: the risk for infectious disease markers
    V Kalibatas
    National Blood Center, Vilnius, Lithuania
    Vox Sang 94:209-15. 2008
    ....
  77. ncbi Hepatitis C prevalence and risk factors in hemodialysis patients in Central Brazil: a survey by polymerase chain reaction and serological methods
    M A Carneiro
    , , , , GO, Brasil
    Mem Inst Oswaldo Cruz 96:765-9. 2001
    ..In addition to anti-HCV screening, HCV RNA detection is necessary for the diagnosis of HCV infection in hemodialysis patients...
  78. pmc Association between hepatitis C virus and very-low-density lipoprotein (VLDL)/LDL analyzed in iodixanol density gradients
    Søren U Nielsen
    Liver Research Group, School of Clinical Medical Sciences, University of Newcastle, England
    J Virol 80:2418-28. 2006
    ..Immunoprecipitation analysis showed that ApoB remained associated with HCV after treatment of serum with deoxycholic acid or NP-40, whereas ApoE was removed from HCV with these detergents...
  79. ncbi Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil
    Carmen L R Lopes
    Instituto de Patologia Tropical e Saude Publica, Universidade Federal de Goias UFG, Goiania, GO, Brasil
    Rev Saude Publica 43:43-50. 2009
    ..To estimate prevalence of hepatitis C virus (HCV) infection and identify risk factors associated and circulating HCV genotypes and subtypes...
  80. ncbi An evidence of high prevalence of Hepatitis C virus in Faisalabad, Pakistan
    Nasir Ahmad
    Health Biotechnology Division, PO Box 577, Jhung Road, Faisalabad, Pakistan
    Saudi Med J 28:390-5. 2007
    ....
  81. ncbi [Prevalence of hepatitis C virus infection in Morocco and serological tests assessment of detection for the viremia prediction]
    A Benouda
    Laboratoire de microbiologie virologie, hôpital universitaire Cheikh Zaid, avenue Allal El Fassi, Madinat Al Irfane Hay Riyad, Rabat 1100, Maroc
    Pathol Biol (Paris) 57:368-72. 2009
    ..This study aims at assessing the prevalence of hepatitis C virus infection (HCV) in Moroccan general population and the efficacy of different virological tests in detection of the viral RNA in order to promote its screening...
  82. ncbi Perinatal transmission of hepatitis C virus infection
    Giuseppe Indolfi
    Department of Paediatrics, University of Florence, Anna Meyer Children s Hospital, Florence, Italy
    J Med Virol 81:836-43. 2009
    ..Despite an increased understanding of the risk factors involved in perinatal transmission of HCV, to date little is known about the transmission mechanisms and timing...
  83. pmc Laboratory assays for diagnosis and management of hepatitis C virus infection
    Sandra S Richter
    Department of Pathology, University of Iowa Health Care, Iowa City, Iowa 52242, USA
    J Clin Microbiol 40:4407-12. 2002
  84. ncbi In vivo and in vitro evidence that cross-reactive antibodies to C-terminus of hypervariable region 1 do not neutralize heterologous hepatitis C virus
    Mariko Esumi
    Department of Pathology, Nihon University School of Medicine, 30 1 Ooyaguchikami machi, Itabashi ku, Tokyo 173 8610, Japan
    Vaccine 20:3095-103. 2002
    ..The data imply that the HVR1 component is insufficient to develop an effective HCV vaccine...
  85. ncbi Hepatitis C virus infection in the general population: a community-based study in West Bengal, India
    Abhijit Chowdhury
    Department of Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata, India
    Hepatology 37:802-9. 2003
    ....
  86. pmc Exposure to low infective doses of HCV induces cellular immune responses without consistently detectable viremia or seroconversion in chimpanzees
    Mohamed Tarek Shata
    New York Blood Center, New York, NY 10021, USA
    Virology 314:601-16. 2003
    ..However, increasing the infective doses of HCV to 100 RNA (+) virions overcame the low-inoculum-induced immune response and produced high-level viremia followed by seroconversion...
  87. pmc Depletion of interfering antibodies in chronic hepatitis C patients and vaccinated chimpanzees reveals broad cross-genotype neutralizing activity
    Pei Zhang
    Division of Hematology and Center for Biologics Evaluation and Research, United States Food and Drug Administration, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:7537-41. 2009
    ..Our studies contribute to understanding the mechanisms of antibody-mediated neutralization and interference and provide a practical approach to the development of more potent and broadly reactive hepatitis C immune globulins...
  88. ncbi Insights into the epidemiology, natural history and pathogenesis of hepatitis C virus infection from studies of infected donors and blood product recipients
    M P Busch
    Blood Centers of the Pacific, San Francisco, CA 94118, United States
    Transfus Clin Biol 8:200-6. 2001
    ..Thus, the findings from studies of HCV among donors and blood product recipients have yielded and should continue to provide important insights into HCV pathogenesis leading to novel diagnostic, therapeutic and vaccination strategies...
  89. ncbi Poor performance of hepatitis C antibody tests in hospital patients in Uganda
    E Seremba
    Makerere University Medical School, Kampala, Uganda
    J Med Virol 82:1371-8. 2010
    ..The prevalence of hepatitis C antibodies in a Ugandan hospital population was determined using both methods to test their accuracy using nucleic ..
  90. pmc Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C
    Jan M Pestka
    Department of Medicine II, University of Freiburg, 79106 Freiburg, Germany
    Proc Natl Acad Sci U S A 104:6025-30. 2007
    ..This finding may have important implications for understanding the pathogenesis of HCV infection and for the development of novel preventive and therapeutic antiviral strategies...
  91. ncbi Hepatitis C virus infection in cameroon: A cohort-effect
    Eric Nerrienet
    Centre Pasteur du Cameroun, Yaounde, Cameroun
    J Med Virol 76:208-14. 2005
    ..This clearly indicates a cohort effect for which the seroprevalence trends are clearly related with the year of birth, rather than the age. The highest prevalence was observed among people born around 1940...
  92. ncbi Prevalence, genotypes and risk factors associated with hepatitis C virus infection in hemodialysis patients in Campo Grande, MS, Brazil
    Solange Z Freitas
    Departamento de Farmacia Bioquimica, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil
    Mem Inst Oswaldo Cruz 103:405-8. 2008
    ..HCV RNA was detected in 12 samples: ten were of genotype 1, subtypes 1a (75%) and 1b (8.3%), and two were of genotype 3, subtype 3a (16.7%)...
  93. ncbi Hepatitis C viral clearance in an intravenous drug-using cohort in the Dublin area
    S Keating
    The Drug Treatment Centre Board, Trinity Court, Pearse Street, Dublin
    Ir J Med Sci 174:37-41. 2005
    ..The rate of spontaneous HCV viral clearance is reported as 20-25% but recent data indicate a higher frequency in some cohorts. The rate of spontaneous clearance in intravenous drug users has not been reported in an Irish setting...
  94. ncbi Patterns of hepatitis C prevalence and seroconversion in hemodialysis units from three continents: the DOPPS
    Rachel B Fissell
    Division of Nephrology, University of Michigan, Ann Arbor, 48105 2303, USA
    Kidney Int 65:2335-42. 2004
    ..Hepatitis C virus (HCV) remains a problem within hemodialysis units. This study measures HCV prevalence and seroconversion rates across seven countries and investigates associations with facility-level practice patterns...
  95. ncbi Prevalence of chronic viral hepatitis in people of south Asian ethnicity living in England: the prevalence cannot necessarily be predicted from the prevalence in the country of origin
    G Uddin
    Queen Marys University of London, Barts and the London School of Medicine, The Liver Unit, 4 Newark Street, London, UK
    J Viral Hepat 17:327-35. 2010
    ..As prevalence varies both by country and region of origin and over time, the prevalence in migrant communities living in western countries cannot be easily predicted from studies in the country of origin...
  96. ncbi Risk factors for perinatal transmission of hepatitis C virus (HCV) and the natural history of HCV infection acquired in infancy
    Eric E Mast
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 192:1880-9. 2005
    ..The goal of the present study was to assess risk factors for perinatal hepatitis C virus (HCV) transmission and the natural history of infection among HCV-infected infants...
  97. ncbi Sex- and age-specific carriers of hepatitis B and C viruses in Japan estimated by the prevalence in the 3,485,648 first-time blood donors during 1995-2000
    Junko Tanaka
    Department of Epidemiology and Control of Infectious Diseases, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan
    Intervirology 47:32-40. 2004
    ..Carriers of hepatitis B virus (HBV) and hepatitis C virus (HCV) in Japan were estimated on a national basis...
  98. ncbi Comparison of the clinical characteristics among hepatocellular carcinoma of hepatitis B, hepatitis C and non-B non-C patients
    Kazufumi Dohmen
    Clinical Research Center, National Nagasaki Medical Center, 2 1001 1 Kubara, Omura, Nagasaki 856 8562, Japan
    Hepatogastroenterology 50:2022-7. 2003
    ..The present study was undertaken to compare the clinical characteristics, availability of initial treatment options and prognostic features of patients with hepatocellular carcinoma in relation to hepatitis B or C viral infection...
  99. ncbi The role of triple infection with hepatitis B virus, hepatitis C virus, and human immunodeficiency virus (HIV) type-1 on CD4+ lymphocyte levels in the highly HIV infected population of North-Central Nigeria
    J C Forbi
    Virology Laboratory, Innovative Biotech Keffi No 1, Keffi, Nasarawa State, Nigeria
    Mem Inst Oswaldo Cruz 102:535-7. 2007
    ..Coinfection with HBV or HCV is relatively common among HIV-infected patients in Nigeria and should be a big consideration in the initiation and choice of therapy...
  100. pmc Human combinatorial libraries yield rare antibodies that broadly neutralize hepatitis C virus
    Daniel X Johansson
    Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital Solna, Karolinska Institutet, 171 76 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:16269-74. 2007
    ....
  101. ncbi Hepatitis C and hepatitis B virus infection in different hemodialysis units in Belo Horizonte, Minas Gerais, Brazil
    Solange U Busek
    DECBI, NUPEB, Universidade Federal de Ouro Preto, Ouro Preto, MG, Brasil
    Mem Inst Oswaldo Cruz 97:775-8. 2002
    ..The HCV genotype 1 was the most frequently observed, followed by the genotype 2, but no correlation was detected between genotype and clinical or epidemiological data...

Research Grants52

  1. HEPATITIS C AND CRYOGLOBULINEMIA
    Warren Schmidt; Fiscal Year: 1999
    ..Cryoprecipitates have been shown to contain RF, anti-hepatitis C antibodies and HCV RNA, however, the role of the virus in the cause of EMC is unclear...
  2. Risk of Blood Borne Transmission of CJD
    Shimian Zou; Fiscal Year: 2008
    ..Publishanddisseminateresultsof thestudy. ..
  3. SUPPORTING ALCOHOL REDUCTION IN HIV+ PATIENTS: A TRAINING FOR HIV CARE PROVIDERS
    Shiela Strauss; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  4. Functional Activities of HCV Core Protein
    Ranjit Ray; Fiscal Year: 2005
    ....
  5. Chemical Genetics:Cellular Regulators of HCV (RMI)
    Raymond Chung; Fiscal Year: 2004
    ..Second, discovery of hit compounds that positively or negatively regulate HCV replication will ultimately help lead to identification of novel cellular targets that can be exploited to further interrupt the viral lifecycle. ..
  6. Immunoglobulin Allotypes in Hepatitis C Virus Infection
    JANARDAN PANDEY; Fiscal Year: 2008
    ..Results of this investigation will advance our understanding of the role of host genetic factors in clearance and persistence of hepatitis C virus infection. ..
  7. Humoral immune response to acute hepatitis C
    Dale Netski; Fiscal Year: 2006
    ..We believe there is a high likelihood this research will be successful, but submit the work initially as an R21 to prove the feasibility of the pseudotype system. ..
  8. QUALITATIVE NATURE OF ANTIBODIES TO HCV GLYCOPROTEIN SUBUNIT VACCINE IN HUMANS
    Ranjit Ray; Fiscal Year: 2009
    ..Our proposed complimentary experimental approaches in this vaccinated cohort will help in developing successful vaccine strategies for the intervention of the first crucial step of the HCV life cycle. ..
  9. NOVEL ANIMAL MODELS OF HCV-RELATED HEPATOCARCINOGENESIS
    Raymond Chung; Fiscal Year: 2003
    ..Together, these models will help provide insights into the factors responsible for this devastating complication of chronic HCV infection. ..
  10. HCV ENVELOPE GLYCOPROTEINS AND VACCINE DEVELOPMENT
    Ranjit Ray; Fiscal Year: 2003
    ....
  11. HIV-Hepatitis C Virus Interactions and Pathogenesis
    Raymond T Chung; Fiscal Year: 2010
    ..These studies will shed considerable light on HIV-HCV pathogenic interactions and offer a means of productively disrupting these interactions. ..
  12. Feasibility for non-Invasive screening for HCV related fibrosis
    Mostafa Mohamed; Fiscal Year: 2008
    ..In phase two a screening program for chronic HCV patients will be established in community liver clinics to perform a cost effective screening program for liver fibrosis ..
  13. Anti-Inflammatory and Anti-Oxidative Nutrition in Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  14. Impaired Glucose Metabolism in HIV-Infected Drug Users
    Andrea Howard; Fiscal Year: 2007
    ..She will also complete coursework in the conduct of diabetes-related clinical research, addiction medicine, and the responsible conduct of research. ..
  15. Cell mediated Immunity to HCV in HIV+ Persons
    Arthur Kim; Fiscal Year: 2007
    ..This plan will be implemented under the supervision of Dr. Bruce Walker, and will involve bench research, data analysis, and didactic learning. [unreadable] [unreadable]..
  16. Modulation of HCV Gene Expression
    Andrea D Branch; Fiscal Year: 2010
    ..New information about HCV's adaptive mechanisms and pathways of gene expression will emerge from these studies and will advance the development of new drugs and vaccines for HCV. ..
  17. Hepatitis B treatment and HIV Infection in resources limited settings
    Chloe L Thio; Fiscal Year: 2010
    ..This proposal has a high likelihood for success given the investigative team's experience, the randomized clinical trial design, and the nesting in an existing study. ..
  18. HCV Alternate Reading Frame Protein in HIV/HCV Co-infect
    Andrea Branch; Fiscal Year: 2007
    ..The yeast two-hybrid system will identify human proteins that bind ARFPs. These studies will identify new targets for therapeutics and vaccine development. ..
  19. Screening for STDs using home sampling in Estonia
    Anneli Uuskula; Fiscal Year: 2007
    ..This information will allow us to identify STD infected individuals, and to develop selective screening criteria to be used in general population studies and screening programs in Estonia. ..
  20. EARLY NATURAL HISTORY OF HCV INFECTION AMONG IDUS
    Ronald Hershow; Fiscal Year: 2006
    ..During the course of the study, all patients will be referred to care at the University of Illinois Medical Center Digestive Disease and Liver Center. Biopsies conducted during normal care will also be used for analysis. ..
  21. Iron Status: A Pathway Analysis in Multiple Ethnicities
    Christine McLaren; Fiscal Year: 2009
    ..Potential study results could be used to identify individuals at risk for iron deficiency and to develop innovative prevention and treatment strategies. ..
  22. Pediatric Clinical Research Scholar Program - Washington
    Naomi Luban; Fiscal Year: 2007
    ..abstract_text> ..
  23. Mechanisms of Innate and Adaptive Immunity In HCV
    David Nelson; Fiscal Year: 2009
    ..A better understanding of the immunologic factors that determine resolution or persistence of the infection may help in the design of therapies and vaccines for the control of HCV infection. ..
  24. Cellular Immune Responses in Subjects Exposed to Hepatitis C
    Sanaa Kamal; Fiscal Year: 2008
    ..Our long-term goal is to mimic this response to develop vaccine strategies or therapeutic protocols capable of preventing persistent hepatitis C infection. [unreadable] [unreadable] [unreadable]..
  25. Characterization of Trypanosoma cruzi in southern Ecuador
    MARIO GRIJALVA; Fiscal Year: 2008
    ..cruzi transmission in the Andean region, which is paramount for the establishment of control programs aimed at stopping transmission of the parasite to human populations. [unreadable] [unreadable] [unreadable]..
  26. HCV-ALCOHOL INTERACTIONS-- PATHOGENESIS AND EPIDEMIOLOGY
    Jack Stapleton; Fiscal Year: 2001
    ..These studies may lead to insights on the mechanism of liver injury and help define those patients who are most likely to have progressive liver injury. ..
  27. Hepatitis Virus, Alcohol Exposure and Oxidative Stress
    Manal Hassan; Fiscal Year: 2002
    ..Serum Se, GPx activity, lipid peroxides and oxidative DNA damage will be measured in relation to HCV and alcohol intake history. ..
  28. CELLULAR IMMUNE RESPONSE IN CHRONIC HEPATITIS C
    David Nelson; Fiscal Year: 2003
    ..These studies will provide insight into basic immunologic principles associated with the host's immune response to this viral infection, as well as provide the basis for new interventional strategies. ..
  29. LIVER RESPONSE TO LPS--ROLE OF LBP AND CD14
    Grace Su; Fiscal Year: 2003
    ..II. Determine the mechanism by which LBP and CD14 accelerate ingestion of Gram-negative bacteria. III. Determine the mechanisms by which LBP/CD14 mediated KC activation promote bacterial killing. ..
  30. RIBOZYMES AND RNA GENE THERAPIES FOR LIVER DISEASES
    Andrea Branch; Fiscal Year: 2003
    ..Northern analysis of RNAs extracted from serum samples of patients will establish the size distribution of HCV RNAs containing the terminal sequence. These studies will lead to new treatments for liver diseases. ..
  31. Features of HCV and Schistosoma mansoni coinfection
    Sanaa Kamal; Fiscal Year: 2004
    ..It is anticipated that investigating this pattern of viral-parasitic interaction will projects will provide useful information for development of more effective diagnostic, prevention and treatment strategies. ..
  32. Neurocognitive Effects of HCV, HIV, and Drug Use
    Scott Letendre; Fiscal Year: 2004
    ..The findings of this research will be used to evaluate the feasibility of an interventional study, and to assist in its design. ..
  33. OPINIONS OF BLOOD DONATION: A U.S. POPULATION SURVEY
    George Schreiber; Fiscal Year: 2005
    ..Findings will be rapidly disseminated to the transfusion medical community and government agencies. ..
  34. Selegiline for Treatment of Cannabis Dependence
    BRENT MOORE; Fiscal Year: 2005
    ..Study findings will also be important in exploring potential mechanism of action of selegiline and establishing a program of research to evaluate medications for cannabis-dependence. ..
  35. Nutritional/Inflammatory Evaluation of Dialysis Patients
    Kamyar Kalantar Zadeh; Fiscal Year: 2005
    ....
  36. Addiction Medicine Physicians and Care for Hepatitis C
    ALAIN LITWIN; Fiscal Year: 2003
    ..Data from this study will have relevance to both drug abuse treatment policy and clinical practice. ..
  37. Adapting to HIV Disease--A Family Intervention
    Michael Stein; Fiscal Year: 2004
    ..Given the significance of families in the AIDS epidemic, it is important to study as well as support families and patients to optimize care of those affected by HIV disease. ..
  38. Antidepressants During Office-based Buprenorphine
    Michael Stein; Fiscal Year: 2008
    ..The focus of this study, the evaluation of combinations of medications, to treat substance-related disorders, fits squarely within the emphasis of this RFA. [unreadable] [unreadable] [unreadable]..
  39. ANTIDEPRESSANT TREATMENT TO REDUCE HIV RISK AMONG IDUS
    Michael Stein; Fiscal Year: 2002
    ..abstract_text> ..
  40. Comprehensive HIV/AIDS Prevention in Egypt
    Mostafa Mohamed; Fiscal Year: 2004
    ..Few, if any, physicians are familiar with the HAART regimen. There is an urgent need to implement evidence-based prevention and treatment programs in the country. ..
  41. A BRIEF ALCOHOL INTERVENTION FOR INCARCERATED WOMEN
    Michael Stein; Fiscal Year: 2007
    ..If effective, this brief alcohol intervention can be readily integrated into existing programs for incarcerated women who will soon be reintegrating into the community. ..
  42. INSOMNIA AND DRUG RELAPSE RISK
    Michael Stein; Fiscal Year: 2009
    ..Our research team is highly experienced in drug research, sleep disorders, and clinical trials in substance abusing populations. ..
  43. XI International Conference on Human Retrovirology: HTLV
    Edward Murphy; Fiscal Year: 2007
    ....
  44. A Brief Marijuana Intervention for Adolescent Women
    Michael Stein; Fiscal Year: 2008
    ..If effective, this brief marijuana intervention can be readily integrated into existing women's primary care sites. ..
  45. A TRIAL TO REDUCE HEPATITIS C AMONG INJECTION DRUG USERS
    Michael Stein; Fiscal Year: 2003
    ..abstract_text> ..
  46. Smoking Cessation Among Methadone Maintained Patients
    Michael Stein; Fiscal Year: 2005
    ..A3. To test the effects of the treatments on methadone treatment outcomes including methadone dose changes and continued use of illicit drugs, as measured by urine toxicologies. ..
  47. MAINTAINING HIV RISK REDUCTION AMONG NEEDLE EXCHANGERS
    Michael Stein; Fiscal Year: 2004
    ..Our results will have policy implications for needle exchange programs where many IDUs have initiated HIV risk reduction. ..
  48. Pathophysiology of HTLV-I and HTLV-II Infection
    Edward Murphy; Fiscal Year: 2008
    ..Blood will be collected from all subjects, and bronchoalveolar lavage fluid and cerebrospinal fluid from subsets with disease, for studies of HTLV virology and immunology. ..
  49. Racial Disparities in Diabetes in the US and the UK
    Arch Mainous; Fiscal Year: 2005
    ..abstract_text> ..
  50. Liver Disease and HIV-HBV Coinfection in the HAART era
    Chloe Thio; Fiscal Year: 2008
    ..Given the experience of the investigative team and the well-characterized cohorts involved, the results from this proposal will yield insights into the management of HIV-HBV co-infected patients. ..
  51. Risks for HIV and STIs among Moscow Sex Workers
    Chris Beyrer; Fiscal Year: 2005
    ..abstract_text> ..