viral antibodies

Summary

Summary: Immunoglobulins produced as a response to VIRAL ANTIGENS; includes all classes of immunoglobulins elicited by all viral components.

Top Publications

  1. ncbi Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States
    R S Lanciotti
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
    Science 286:2333-7. 1999
  2. ncbi Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
    D W Vaughn
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Infect Dis 181:2-9. 2000
  3. ncbi Dengue
    Scott B Halstead
    Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
    Lancet 370:1644-52. 2007
  4. pmc B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus
    Michael S Diamond
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Virol 77:2578-86. 2003
  5. ncbi Neutralization and antibody-dependent enhancement of dengue viruses
    Scott B Halstead
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Adv Virus Res 60:421-67. 2003
  6. ncbi Fruit bats as reservoirs of Ebola virus
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Nature 438:575-6. 2005
  7. pmc Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street JFB 826, Boston, Massachusetts 02115, USA
    Nat Struct Mol Biol 16:265-73. 2009
  8. pmc Introduction of West Nile virus in the Middle East by migrating white storks
    Mertyn Malkinson
    Kirmon Veterinary Institute, Beit Dagan, Isreal
    Emerg Infect Dis 8:392-7. 2002
  9. pmc Efficient intracellular assembly of papillomaviral vectors
    Christopher B Buck
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 4263, USA
    J Virol 78:751-7. 2004
  10. ncbi Nipah virus: a recently emergent deadly paramyxovirus
    K B Chua
    Department of Medical Microbiology, University of Malaya Medical Center, 50603 Kuala Lumpur, Malaysia
    Science 288:1432-5. 2000

Detail Information

Publications270 found, 100 shown here

  1. ncbi Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States
    R S Lanciotti
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
    Science 286:2333-7. 1999
    ..This North American WN virus was most closely related to a WN virus isolated from a dead goose in Israel in 1998...
  2. ncbi Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
    D W Vaughn
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Infect Dis 181:2-9. 2000
    ..6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type...
  3. ncbi Dengue
    Scott B Halstead
    Supportive Research and Development, Pediatric Dengue Vaccine Initiative, Internal Vaccine Institute, Seoul, South Korea
    Lancet 370:1644-52. 2007
    ..Here, I review and discuss data on clinical diagnosis and pathophysiology of vascular permeability and coagulopathy, parenteral treatment of DHF/DSS, and new laboratory tests...
  4. pmc B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus
    Michael S Diamond
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Virol 77:2578-86. 2003
    ..We conclude that antibodies and B cells play a critical early role in the defense against disseminated infection by WNV...
  5. ncbi Neutralization and antibody-dependent enhancement of dengue viruses
    Scott B Halstead
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Adv Virus Res 60:421-67. 2003
  6. ncbi Fruit bats as reservoirs of Ebola virus
    Eric M Leroy
    Centre International de Recherches Medicales de Franceville, BP 769 Franceville, Gabon
    Nature 438:575-6. 2005
    ..We find evidence of asymptomatic infection by Ebola virus in three species of fruit bat, indicating that these animals may be acting as a reservoir for this deadly virus...
  7. pmc Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
    Jianhua Sui
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street JFB 826, Boston, Massachusetts 02115, USA
    Nat Struct Mol Biol 16:265-73. 2009
    ..Our data further suggest that this region is recalcitrant to neutralization escape and that nAb-based immunotherapy is a promising strategy for broad-spectrum protection against seasonal and pandemic influenza viruses...
  8. pmc Introduction of West Nile virus in the Middle East by migrating white storks
    Mertyn Malkinson
    Kirmon Veterinary Institute, Beit Dagan, Isreal
    Emerg Infect Dis 8:392-7. 2002
    ..Since these storks were migrating southwards for the first time and had not flown over Israel, we assume that they had become infected with WNV at some point along their route of migration in Europe...
  9. pmc Efficient intracellular assembly of papillomaviral vectors
    Christopher B Buck
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892 4263, USA
    J Virol 78:751-7. 2004
    ..The results suggest that the intracellular assembly of papillomavirus structural proteins around heterologous reporter plasmids is surprisingly promiscuous and may be driven primarily by a size discrimination mechanism...
  10. ncbi Nipah virus: a recently emergent deadly paramyxovirus
    K B Chua
    Department of Medical Microbiology, University of Malaya Medical Center, 50603 Kuala Lumpur, Malaysia
    Science 288:1432-5. 2000
    ..Like Hendra virus, Nipah virus is unusual among the paramyxoviruses in its ability to infect and cause potentially fatal disease in a number of host species, including humans...
  11. pmc The stoichiometry of antibody-mediated neutralization and enhancement of West Nile virus infection
    Theodore C Pierson
    Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Host Microbe 1:135-45. 2007
    ..Thus, neutralization is best described by a model requiring "multiple hits" with the cumulative functional outcome determined by interplay between antibody affinity and epitope accessibility...
  12. ncbi The outbreak of West Nile virus infection in the New York City area in 1999
    D Nash
    Communicable Disease Program, New York City Department of Health, New York 10013, USA
    N Engl J Med 344:1807-14. 2001
    ..The initial epidemiologic and environmental investigations suggested an arboviral cause...
  13. ncbi Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus
    Kathy Hancock
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 361:1945-52. 2009
    ....
  14. ncbi Structural basis of West Nile virus neutralization by a therapeutic antibody
    Grant E Nybakken
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 437:764-9. 2005
    ..Collectively, our results suggest that a vaccine strategy targeting the dominant DIII epitope may elicit safe and effective immune responses against flaviviral diseases...
  15. ncbi Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein
    Suzanne L Epstein
    Laboratory of Immunology and Developmental Biology, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike, Bethesda, MD 20852, USA
    Vaccine 23:5404-10. 2005
    ..Thus, gene-based vaccination with NP may contribute to protective immunity against diverse influenza viruses through its ability to stimulate cellular immunity...
  16. ncbi Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity
    Andrea Jegerlehner
    Cytos Biotechnology, Schlieren, Switzerland
    J Immunol 172:5598-605. 2004
    ....
  17. ncbi Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand
    Timothy P Endy
    Division of Virology, United States Army Medical Research Institute of Infectious Diseases, United States Army Medical Research and Materiel Command, Ft Detrick, Maryland, USA
    J Infect Dis 189:990-1000. 2004
    ..Most DHF cases occur after sequential heterotypic DV infections. The role of preexisting humoral immunity in modifying severity of dengue disease is not well understood...
  18. pmc West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis
    S Y Xiao
    Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    Emerg Infect Dis 7:714-21. 2001
    ..Hamsters offer an inexpensive model for studying the pathogenesis and treatment of WN virus encephalitis...
  19. ncbi Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
    Vincent C Lombardi
    Whittemore Peterson Institute, Reno, NV 89557, USA
    Science 326:585-9. 2009
    ..These findings raise the possibility that XMRV may be a contributing factor in the pathogenesis of CFS...
  20. ncbi Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins
    Shee Mei Lok
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
    Nat Struct Mol Biol 15:312-7. 2008
    ..The changes in the structure of the viral surface are presumably responsible for inhibiting attachment to cells...
  21. ncbi Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin
    James W Huleatt
    VaxInnate Corporation, 300 George Street, New Haven, CT 06511, USA
    Vaccine 26:201-14. 2008
    ..These data demonstrate that the linkage of specific TLR ligand with influenza M2e yields a vaccine candidate that offers significant promise for widespread protection against multiple influenza A virus strains...
  22. ncbi Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity
    S B Boppana
    Department of Pediatrics, University of Alabama at Birmingham, 35233, USA
    N Engl J Med 344:1366-71. 2001
    ..Whether congenital CMV infection in the offspring of women who are seropositive for CMV can occur after maternal reinfection with a different strain of CMV is unknown...
  23. ncbi Epidemic West Nile encephalitis, New York, 1999: results of a household-based seroepidemiological survey
    F Mostashari
    Communicable Disease Program, New York City Department of Health, NY 10013, USA
    Lancet 358:261-4. 2001
    ..We did a household-based seroepidemiological survey to assess more clearly the public-health impact of the epidemic, its range of illness, and risk factors associated with infection...
  24. pmc Localization and characterization of flavivirus envelope glycoprotein cross-reactive epitopes
    Wayne D Crill
    Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, P O Box 2087, Fort Collins, CO 80522, USA
    J Virol 78:13975-86. 2004
    ..The third epitope consists of discontinuous residues that are structurally related to the strictly conserved tryptophan at dengue virus serotype 2 E-glycoprotein position 231...
  25. ncbi Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons
    A Wald
    Department of Medicine, University of Washington, Seattle 98122, USA
    N Engl J Med 342:844-50. 2000
    ..Historically, it has been assumed that these persons have less frequent viral reactivation than those with symptomatic infection...
  26. ncbi Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40
    Wendy A Knowles
    Enteric, Respiratory and Neurological Virus Laboratory, Specialist and Reference Microbiology Division, Health Protection Agency, Colindale, London, United Kingdom
    J Med Virol 71:115-23. 2003
    ..There is no serological evidence that SV40 entered the human population during the past 80 years, and the possibility of cross-reaction with BKV or JCV antibody must be considered...
  27. pmc Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cells
    W D Crill
    Arbovirus Disease Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Virol 75:7769-73. 2001
    ..These results extend our understanding of the structure-function relationships in the E glycoprotein of DEN virus and provide the first direct evidence that domain III encodes the primary flavivirus receptor-binding motif...
  28. ncbi Porcine circovirus type 2 associated disease: update on current terminology, clinical manifestations, pathogenesis, diagnosis, and intervention strategies
    Tanja Opriessnig
    Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA
    J Vet Diagn Invest 19:591-615. 2007
    ..This article is intended to discuss the most common disease manifestations, pathogenesis, diagnostic approaches, and intervention strategies associated with PCVAD in North America...
  29. ncbi Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement
    Panisadee Avirutnan
    Medical Molecular Biology Unit, Siriraj Hospital, Mahidol University, Bangkok, Thailand
    J Infect Dis 193:1078-88. 2006
    ..Thirty years ago, complement activation was proposed to be a key underlying event, but the cause of complement activation has remained unknown...
  30. pmc Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays
    Yanis L Tolstov
    Molecular Virology Program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Int J Cancer 125:1250-6. 2009
    ..Our study demonstrates that MCV is a widespread but previously unrecognized human infection...
  31. pmc A critical role for induced IgM in the protection against West Nile virus infection
    Michael S Diamond
    Washington University School of Medicine, 660 S Euclid Ave, Box 8051, St Louis, MO 63110, USA
    J Exp Med 198:1853-62. 2003
    ..Thus, the induction of a specific, neutralizing IgM response early in the course of WNV infection limits viremia and dissemination into the central nervous system, and protects against lethal infection...
  32. pmc High sustained efficacy of a prophylactic quadrivalent human papillomavirus types 6/11/16/18 L1 virus-like particle vaccine through 5 years of follow-up
    L L Villa
    Ludwig Institute for Cancer Research, R Prof Antonio Prudente 109, 01509 010 Sao Paulo, SP, Brazil
    Br J Cancer 95:1459-66. 2006
    ..This duration supports vaccination of adolescents and young adults, which is expected to greatly reduce the burden of cervical and genital cancers, precancerous dysplasia, and genital warts...
  33. ncbi Reactivity of human sera in a sensitive, high-throughput pseudovirus-based papillomavirus neutralization assay for HPV16 and HPV18
    Diana V Pastrana
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4263, USA
    Virology 321:205-16. 2004
    ..The SEAP pseudovirus-based neutralization assay should be a practical method for quantifying potentially protective antibody responses in HPV natural history and prophylactic vaccine studies...
  34. ncbi Serotype-specific differences in clinical manifestations of dengue
    Angel Balmaseda
    Departamento de Virologia, Centro Nacional de Diagnostico y Referencia, Ministerio de Salud, Managua, Nicaragua
    Am J Trop Med Hyg 74:449-56. 2006
    ..86, CI 2.72-5.48) and more primary DENV infections with severe manifestations (OR 2.93, CI 2.00-4.28). These findings provide new data to characterize the pathogenic potential of distinct DENV serotypes in human populations...
  35. pmc European bat lyssavirus infection in Spanish bat populations
    Jordi Serra-Cobo
    Universitat de Barcelona, Barcelona, Spain
    Emerg Infect Dis 8:413-20. 2002
    ..At least one of this species (M. schreibersii) is migratory and thus could be partially responsible for the dissemination of EBL1 on both shores of the Mediterranean Sea...
  36. pmc Isolation and characterization of human monoclonal antibodies from individuals infected with West Nile Virus
    Mark Throsby
    Crucell Holland B V, P O Box 2048, 2301 CA, Leiden, The Netherlands
    J Virol 80:6982-92. 2006
    ....
  37. ncbi Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2
    Krystyna Mozdzanowska
    Immunology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104 4268, USA
    Vaccine 21:2616-26. 2003
    ..Importantly, the protection in M2e-MAP- and infection-immunized mice appeared to be mediated by distinct immune mechanisms. This suggests that stronger protection may be achievable by combining both protective activities...
  38. ncbi Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection
    Angelo De Milito
    Microbiology and Tumor Biology Center, Karolinska Institute, and Gay Men s Health Clinic, The Soder Hospital, Stockholm, Sweden
    Blood 103:2180-6. 2004
    ..Our results may be relevant to the design of HIV-1 therapeutical vaccines and to the clinical management of HIV-1-infected patients...
  39. ncbi The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus
    Gunilla B Karlsson Hedestam
    Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden
    Nat Rev Microbiol 6:143-55. 2008
    ..Efforts to develop broadly neutralizing vaccines against either HIV-1 or influenza virus might establish a paradigm for future vaccines against highly variable pathogens...
  40. pmc Quantitation of human seroresponsiveness to Merkel cell polyomavirus
    Diana V Pastrana
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, USA
    PLoS Pathog 5:e1000578. 2009
    ..This suggests that a VLP-based vaccine could be effective for preventing the initial establishment of MCV infection...
  41. pmc Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primates
    William M Switzer
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 78:2780-9. 2004
    ..Our data highlight the importance of studies to better define the public health implications of zoonotic SFV infections...
  42. ncbi A rapid and quantitative assay for measuring antibody-mediated neutralization of West Nile virus infection
    Theodore C Pierson
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Virology 346:53-65. 2006
    ..WNV RVPs are capable of only a single round of infection, can be used under BSL-2 conditions, and offer a rapid and quantitative approach for detecting virus entry and its inhibition by neutralizing antibody...
  43. pmc Simultaneous quantitation of antibodies to neutralizing epitopes on virus-like particles for human papillomavirus types 6, 11, 16, and 18 by a multiplexed luminex assay
    David Opalka
    Virus and Cell Biology, Merck Research Laboratories, Wayne, Pennsylvania 19087 8630, USA
    Clin Diagn Lab Immunol 10:108-15. 2003
    ....
  44. ncbi The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection
    Kao Jean Huang
    Department of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
    J Immunol 176:2825-32. 2006
    ....
  45. ncbi Correlation between direct ELISA, single epitope-based inhibition ELISA and pseudovirion-based neutralization assay for measuring anti-HPV-16 and anti-HPV-18 antibody response after vaccination with the AS04-adjuvanted HPV-16/18 cervical cancer vaccine
    Francis J Dessy
    Research and Development, GlaxoSmithKline Biologicals, Rixensart, Belgium
    Hum Vaccin 4:425-34. 2008
    ..4 years) and the age of the vaccine recipient...
  46. ncbi Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract
    Kathryn B Renegar
    Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 173:1978-86. 2004
    ....
  47. pmc Nipah virus infection in bats (order Chiroptera) in peninsular Malaysia
    J M Yob
    Veterinary Research Institute, Ipoh, Perak, Malaysia
    Emerg Infect Dis 7:439-41. 2001
    ..We collected 324 bats from 14 species on peninsular Malaysia. Neutralizing antibodies to Nipah virus were demonstrated in five species, suggesting widespread infection in bat populations in peninsular Malaysia...
  48. ncbi Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles
    Thanh Hung Nguyen
    Department of Dengue Hemorrhagic Fever, Children s Hospital No 1 Ho Chi Minh City, Vietnam
    J Infect Dis 189:221-32. 2004
    ..Overproduction of both proinflammatory cytokines (interferon-gamma and tumor necrosis factor-alpha) and anti-inflammatory cytokines (interleukin-10 and -6) may play a role in the pathogenesis of DHF/DSS in infants...
  49. ncbi Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men
    Y C Chien
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    N Engl J Med 345:1877-82. 2001
    ..CONCLUSIONS: IgA antibodies against EBV capsid antigen and neutralizing antibodies against EBV DNase are predictive of nasopharyngeal carcinoma...
  50. ncbi Passive protection against lethal enterovirus 71 infection in newborn mice by neutralizing antibodies elicited by a synthetic peptide
    Damian Guang Wei Foo
    Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, MD4A, 5 Science Drive 2, Singapore 117597, Singapore
    Microbes Infect 9:1299-306. 2007
    ..In conclusion, EV71-neutralizing antibodies elicited by the synthetic peptide SP70 were able to confer good in vivo passive protection against homologous and heterologous EV71 strains in suckling Balb/c mice...
  51. ncbi Dengue: an update
    Maria G Guzman
    Virology Department, PAHO WHO Collaborating Center for Viral Diseases, Pedro Kouri Tropical Medicine Institute, Autopista Novia del Mediodia, Km 6, PO Box Marianao 13, Ciudad Habana, Cuba
    Lancet Infect Dis 2:33-42. 2002
    ..We describe the status of vaccine development and emphasise that the only alternative that we have today to control the disease is through control of its vector Aedes aegypti...
  52. ncbi Development of a fluorescent antibody virus neutralisation test (FAVN test) for the quantitation of rabies-neutralising antibody
    F Cliquet
    CNEVA Nancy, Laboratoire d études sur la rage et la pathologie des animaux sauvages, Malzeville, France
    J Immunol Methods 212:79-87. 1998
    ..Furthermore, distinguishing negative sera from positive sera with low titres is much easier with the FAVN test than with the RFFIT...
  53. ncbi Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections
    V C Huber
    Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA
    J Immunol 166:7381-8. 2001
    ..We conclude that Fc receptor-mediated phagocytosis plays a pivotal role in clearance of respiratory virus infections...
  54. ncbi Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis
    Samantha Jilek
    Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Brain 131:1712-21. 2008
    ..Our data show high levels of CD8+ T-cell activation against EBV--but not CMV--early in the course of MS, which support the hypothesis that EBV might be associated with the onset of this disease...
  55. pmc Heterosubtypic neutralizing monoclonal antibodies cross-protective against H5N1 and H1N1 recovered from human IgM+ memory B cells
    Mark Throsby
    Crucell Holland BV, Leiden, The Netherlands
    PLoS ONE 3:e3942. 2008
    ..Furthermore, there are 16 different HA subtypes and no certainty the next pandemic will be caused by an H5 subtype, thus it is important to develop prophylactic and therapeutic interventions that provide heterosubtypic protection...
  56. ncbi Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study
    Brenda Banwell
    Division of Neurology, The Hospital for Sick Children, University of Toronto, ON, Canada
    Lancet Neurol 6:773-81. 2007
    ..Our aim was to determine some of these characteristics in children with MS...
  57. ncbi Safety and immunogenicity of a prototype adjuvanted inactivated split-virus influenza A (H5N1) vaccine in infants and children
    Terry Nolan
    Melbourne School of Population Health, The University of Melbourne, Victoria, Australia
    Vaccine 26:6383-91. 2008
    ....
  58. ncbi Human metapneumovirus infections in young and elderly adults
    Ann R Falsey
    Infectious Diseases Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, 1425 Portland Avenue, Rochester, NY 14621, USA
    J Infect Dis 187:785-90. 2003
    ..In conclusion, hMPV infection occurs in adults of all ages and may account for a significant portion of persons hospitalized with respiratory infections during some years...
  59. pmc West Nile outbreak in horses in southern France, 2000: the return after 35 years
    B Murgue
    Centre National de Référence des Arbovirus et des Fièvres hémorragiques virales, Institut Pasteur 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    Emerg Infect Dis 7:692-6. 2001
    ..No human case has been confirmed among clinically suspected patients, nor have abnormal deaths of birds been reported. A serosurvey has been undertaken in horses in the infected area, and other studies are in progress...
  60. pmc Henipavirus and Tioman virus antibodies in pteropodid bats, Madagascar
    Catherine Iehle
    Institut Pasteur de Madagascar, Antananarivo, Madagascar
    Emerg Infect Dis 13:159-61. 2007
    ..Antibodies against Nipah, Hendra, and Tioman viruses were detected by immunoassay in 23 and by serum neutralization tests in 3 of 427 serum samples, which suggests that related viruses have circulated in Madagascar...
  61. ncbi Evaluation of the Panbio dengue virus nonstructural 1 antigen detection and immunoglobulin M antibody enzyme-linked immunosorbent assays for the diagnosis of acute dengue infections in Laos
    Stuart D Blacksell
    Wellcome Trust Mahosot Hospital Oxford Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
    Diagn Microbiol Infect Dis 60:43-9. 2008
    ....
  62. pmc The detection of antibodies against peste des petits ruminants virus in cattle, sheep and goats and the possible implications to rinderpest control programmes
    J Anderson
    ARFC Institute for Animal Health, Pirbright Laboratory, Woking, Surrey, UK
    Epidemiol Infect 112:225-31. 1994
    ....
  63. pmc Protective immunity to vaccinia virus induced by vaccination with multiple recombinant outer membrane proteins of intracellular and extracellular virions
    Christiana Fogg
    Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Virol 78:10230-7. 2004
    ..Three immunizations with the three-protein combination were necessary and sufficient for complete protection. These studies suggest the feasibility of a multiprotein smallpox vaccine...
  64. ncbi Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999
    Ananda Nisalak
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Trop Med Hyg 68:191-202. 2003
    ..Our findings illustrate the uniqueness of each serotype in producing epidemics and severe disease and underscore the importance of long-term surveillance of dengue serotypes in understanding the epidemiology of these viruses...
  65. pmc An outbreak of Rift Valley fever in Northeastern Kenya, 1997-98
    Christopher W Woods
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 8:138-44. 2002
    ..Public education during epizootics may reduce human illness and deaths associated with future outbreaks...
  66. ncbi Functional role of type I and type II interferons in antiviral defense
    U Muller
    Institute of Molecular Biology I, University of Zurich, Switzerland
    Science 264:1918-21. 1994
    ..Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant...
  67. pmc Studies of reservoir hosts for Marburg virus
    Robert Swanepoel
    National Institute for Communicable Diseases, Sandringham, Republic of South Africa
    Emerg Infect Dis 13:1847-51. 2007
    ..6% of 2 species of insectivorous bat and 1 species of fruit bat. We found antibody to the virus in the serum of 9.7% of 1 of the insectivorous species and in 20.5% of the fruit bat species, but attempts to isolate virus were unsuccessful...
  68. ncbi Guidelines for Plaque-Reduction Neutralization Testing of Human Antibodies to Dengue Viruses
    John T Roehrig
    National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Fort Collins, Colorado, USA
    Viral Immunol 21:123-32. 2008
    ..A more complete version of these guidelines is available on the WHO website: http://www.who.int/immunization/documents/date/en/index.html...
  69. pmc Antibodies to envelope glycoprotein of dengue virus during the natural course of infection are predominantly cross-reactive and recognize epitopes containing highly conserved residues at the fusion loop of domain II
    Chih Yun Lai
    Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Virol 82:6631-43. 2008
    ..These findings have implications for our understanding of the pathogenesis of dengue and for the future design of subunit vaccine against DENV as well...
  70. ncbi A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity
    William F McDonald
    VaxInnate Corporation, New Haven, CT 06511, USA
    J Infect Dis 195:1607-17. 2007
    ..They also support the further development of an effective WNV vaccine and novel monovalent and multivalent vaccines for related flaviviruses...
  71. ncbi Occupancy and mechanism in antibody-mediated neutralization of animal viruses
    P J Klasse
    Jefferiss Research Trust Laboratories, Wright Fleming Institute, Imperial College of Science, Technology and Medicine, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    J Gen Virol 83:2091-108. 2002
    ..Examples of neutralization mediated through antibody interference with virus attachment and entry are discussed and test implications of refined theories of neutralization by antibody coating of virions are formulated...
  72. ncbi Cytokines, autoantibodies and viral antibodies in premorbid and postdiagnostic sera from patients with rheumatoid arthritis: case-control study nested in a cohort of Norwegian blood donors
    K T Jørgensen
    Department of Epidemiology Research, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen, Denmark
    Ann Rheum Dis 67:860-6. 2008
    To assess the timing of changes in cytokines, cytokine-related markers, autoantibodies and viral antibodies in the pathogenesis of rheumatoid arthritis (RA).
  73. ncbi Monoclonal antibody mapping of the envelope glycoprotein of the dengue 2 virus, Jamaica
    J T Roehrig
    Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Virology 246:317-28. 1998
    ..Domains A and B were spatially associated. As with tick-borne encephalitis virus, determination of domain C was more problematic; however, at least four epitopes had biochemical characteristics consistent with C-domain epitopes...
  74. pmc Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza
    Victor C Huber
    Deparment of Infectious Disease, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Clin Vaccine Immunol 13:981-90. 2006
    ..This study details separate but important roles for both IgG1 and IgG2a expression in vaccination against influenza and argues for the development of vaccine regimens that stimulate and measure expression of both antibody isotypes...
  75. pmc Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor
    Jeffrey E Lee
    Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, Mail Drop IMM 2, La Jolla, California 92037, USA
    Nature 454:177-82. 2008
    ..This structure provides a template for unravelling the mechanism of EBOV GP-mediated fusion and for future immunotherapeutic development...
  76. pmc Human monoclonal antibodies against West Nile virus induced by natural infection neutralize at a postattachment step
    Matthew R Vogt
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 83:6494-507. 2009
    ..CR4348 and CR4354 human MAbs neutralize infection at a postattachment step in the viral life cycle, likely by inhibiting acid-induced fusion within the endosome...
  77. pmc Development and evaluation of an Influenza virus subtype H7N2 vaccine candidate for pandemic preparedness
    Claudia Pappas
    Influenza Division, Mailstop G 16, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Clin Vaccine Immunol 14:1425-32. 2007
    ..These studies indicate that H7N2-PR8 is immunogenic, safe, and protective in animal models; these are the essential attributes to qualify for phase I human clinical trials as a prepandemic vaccine...
  78. ncbi Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and older
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY, USA
    J Infect Dis 200:172-80. 2009
    ..To improve the immunogenicity of influenza vaccine, a high-dose (HD) trivalent, inactivated influenza vaccine was developed...
  79. ncbi Transmission of West Nile virus from an organ donor to four transplant recipients
    Martha Iwamoto
    Epidemic Intelligence Service, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta 30333, USA
    N Engl J Med 348:2196-203. 2003
    ..In August 2002, fever and mental-status changes developed in recipients of organs from a common donor. Transmission of West Nile virus through organ transplantation was suspected...
  80. ncbi Characterization of an antigenic site that contains a dominant, type-specific neutralization determinant on the envelope protein domain III (ED3) of dengue 2 virus
    Gregory D Gromowski
    Department of Pathology, Sealy Center for Vaccine Development, Center for Biodefense and Emerging Infectious Diseases, and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    Virology 366:349-60. 2007
    ..Overall, the conserved antigenic site recognized by all seven MAbs is likely to be a dominant DENV-2 type-specific, neutralization determinant...
  81. ncbi West Nile virus activity in Latin America and the Caribbean
    Nicholas Komar
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, PO Box 2087, Fort Collins, Colorado 80522, USA
    Rev Panam Salud Publica 19:112-7. 2006
    ..West Nile virus (Flavivirus: Flaviviridae; WNV) has spread rapidly throughout the Caribbean Basin since its initial detection there in 2001. This report summarizes our current knowledge of WNV transmission in tropical America...
  82. ncbi Isolation of Nipah virus from Malaysian Island flying-foxes
    Kaw Bing Chua
    Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Lumpur, Kuala, Malaysia
    Microbes Infect 4:145-51. 2002
    ..The isolation of Nipah virus from the Island flying-fox corroborates the serological evidence that it is one of the natural hosts of the virus...
  83. ncbi Susceptibility of North American big brown bats (Eptesicus fuscus) to infection with European bat lyssavirus type 1
    R Franka
    Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop G33, Atlanta, GA 30333, USA
    J Gen Virol 89:1998-2010. 2008
    ..d.) routes could lead to an abortive infection and serve as a natural mode of immunization resulting in the presence of virus-neutralizing antibodies in free-ranging bats...
  84. ncbi Influence of the dengue serotype, previous dengue infection, and plasma viral load on clinical presentation and outcome during a dengue-2 and dengue-4 co-epidemic
    Laurent Thomas
    Service des Urgences, Centre Hospitalier Universitaire, Fort de France, Martinique
    Am J Trop Med Hyg 78:990-8. 2008
    ..The most severe cases of dengue resulted from the combined effects of DENV-2 and secondary infection...
  85. pmc Lymphocyte and antibody responses reduce enterovirus 71 lethality in mice by decreasing tissue viral loads
    Yu Wen Lin
    Institute of Biomedical Sciences, National Cheng Kung University, Tainan, Taiwan 701, Republic of China
    J Virol 83:6477-83. 2009
    ..Our study suggests the use of vaccines and virus-specific antibodies to control fatal outbreaks and raises caution over the use of corticosteroids to treat EV71-infected patients with neurological symptoms...
  86. ncbi High seroprevalence of Epstein-Barr virus in children with multiple sclerosis
    D Pohl
    Brauweg 19, 37073 Goettingen, Germany
    Neurology 67:2063-5. 2006
    ..6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls...
  87. ncbi A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodies
    Nigel J Temperton
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London, United Kingdom
    Influenza Other Respir Viruses 1:105-12. 2007
    ..We have used retroviral pseudotypes bearing influenza H5 hemagglutinin (HA) as safe, surrogate viruses for influenza neutralization assays which can be carried out at Biosafety Level 2...
  88. ncbi Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins
    A K Falconar
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, U K
    Arch Virol 144:2313-30. 1999
    ..These peptide sequence will now be tested for their ability to generate cross-protective antibodies against each dengue virus serotype when delivered with appropriate T-helper epitopes...
  89. pmc Investigating antibody neutralization of lyssaviruses using lentiviral pseudotypes: a cross-species comparison
    Edward Wright
    MRC UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, 46 Cleveland Street, London W1T 4JF, UK
    J Gen Virol 89:2204-13. 2008
    ....
  90. pmc Effect of preexisting immunity on an adenovirus vaccine vector: in vitro neutralization assays fail to predict inhibition by antiviral antibody in vivo
    Susan L Pichla-Gollon
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Virol 83:5567-73. 2009
    ..The results thus suggest that in vitro neutralization assays may not reliably predict the effects of virus-specific antibodies on adenovirus vectors in vivo...
  91. pmc Serologic evidence of H1 swine Influenza virus infection in swine farm residents and employees
    Christopher W Olsen
    University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Emerg Infect Dis 8:814-9. 2002
    ..Because pigs can play a role in generating genetically novel influenza viruses, swine farmers may represent an important sentinel population to evaluate the emergence of new pandemic influenza viruses...
  92. ncbi Temporal relationship between elevation of epstein-barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis
    Lynn I Levin
    Division of Preventive Medicine, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    JAMA 293:2496-500. 2005
    ..Infection with Epstein-Barr virus (EBV) has been associated with an increased risk of multiple sclerosis (MS), but the temporal relationship remains unclear...
  93. ncbi Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection
    Manfred Kopf
    Molecular Biomedicine, Department of Environmental Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Nat Med 8:373-8. 2002
    ..Consequently, T-helper cell-dependent IgG responses were reduced in C3-/- mice but remained intact in Cr2-/- mice. These results demonstrate that complement induces specific immunity by promoting T-cell responses...
  94. pmc Reproduction and nutritional stress are risk factors for Hendra virus infection in little red flying foxes (Pteropus scapulatus)
    Raina K Plowright
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Proc Biol Sci 275:861-9. 2008
    ..These insights into the ecology of HeV in flying fox populations suggest causal links between anthropogenic environmental change and HeV emergence...
  95. pmc Maturation of West Nile virus modulates sensitivity to antibody-mediated neutralization
    Steevenson Nelson
    Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 4:e1000060. 2008
    ..Thus, in addition to a role in facilitating viral entry, changes in E protein arrangement associated with maturation modulate neutralization sensitivity and introduce an additional layer of complexity into humoral immunity against WNV...
  96. ncbi Response to a monovalent 2009 influenza A (H1N1) vaccine
    Michael E Greenberg
    Clinical Research and Development, CSL, Parkville, Vic, Australia
    N Engl J Med 361:2405-13. 2009
    ..A randomized, observer-blind, parallel-group trial evaluating two doses of an inactivated, split-virus 2009 H1N1 vaccine in healthy adults between the ages of 18 and 64 years is ongoing at a single site in Australia...
  97. pmc Absence of evidence of xenotropic murine leukemia virus-related virus infection in persons with chronic fatigue syndrome and healthy controls in the United States
    William M Switzer
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Retrovirology 7:57. 2010
    ..Blinded PCR and serologic testing were performed at the US Centers for Disease Control and Prevention (CDC) and at two additional laboratories...
  98. ncbi Dengue virus infection and immune response in humanized RAG2(-/-)gamma(c)(-/-) (RAG-hu) mice
    Jes G Kuruvilla
    Department of Microbiology, Immunology and Pathology, 1619 Campus Delivery, Colorado State University, Fort Collins, CO 80523 1619, USA
    Virology 369:143-52. 2007
    ..These results demonstrate for the first time that humanized mice are capable of dengue viral primary human immune responses thus paving the way for new dengue immunopathogenesis and vaccine studies...
  99. pmc Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant
    Maria Grazia Revello
    Servizio di Virologia, IRCCS Policlinico San Matteo, 27100 Pavia, Italy
    Clin Microbiol Rev 15:680-715. 2002
    ....
  100. pmc Testing human sera for antibodies against avian influenza viruses: horse RBC hemagglutination inhibition vs. microneutralization assays
    Ghazi Kayali
    Center for Emerging Infectious Diseases, Department of Epidemiology, College of Public Health, University of Iowa, Oakdale Research Park, MTF B145, 2501 Crosspark Road, Coralville, IA 52241 8802, United States
    J Clin Virol 43:73-8. 2008
    ..Recent research suggests that the sensitivity of the HI assay can be improved by switching from the traditionally used turkey, guinea pig, human, or chicken RBCs to horse RBCs...
  101. pmc Serologic evidence of frequent human infection with WU and KI polyomaviruses
    Nang L Nguyen
    Washington University in St Louis, Missouri 63110, USA
    Emerg Infect Dis 15:1199-205. 2009
    ..These results demonstrate that both KIPyV and WUPyV cause widespread infection in the human population...

Research Grants81

  1. Molecular Regulation of VH Gene Replacement in Human Immature B Cells
    Zhixin Zhang; Fiscal Year: 2012
    ..of VH replacement products are significantly elevated in autoimmune diseases and in IgH genes encoding anti-viral antibodies, suggesting an unrealized important function of VH replacement...
  2. Targeting Viral Envelope Glycoproteins with Synthetic Antibodies
    Jonathan Lai; Fiscal Year: 2013
    ..Many viral antibodies borne from this progenitor exhibit similar modes of interaction with their viral antigens, suggesting that ..
  3. Rituximab for Treatment of Type 1 Diabetes: Impact on JC Viral Proliferation
    MARK DAVID PESCOVITZ; Fiscal Year: 2010
    ..We will compare anti-viral antibodies levels over time as well.
  4. Understanding human neutralizing antibodies to hepatitis C virus
    Mansun Law; Fiscal Year: 2013
    ..in the Action Plan for Liver Disease of the National Institutes of Health is to develop means, including anti-viral antibodies, to prevent recurrence of hepatitis C virus (HCV) after liver transplantation...
  5. Anti-Tumor Immunity in Response to a Modified Vaccine Strain Measles Virus
    Tobias Peikert; Fiscal Year: 2013
    ..Suboptimal viral replication and pre-existing neutralizing anti-viral antibodies implicate immune mediated destruction rather than oncolysis...
  6. High-throughput Epitope Mapping of Anti-Viral Antibodies
    BENJAMIN JACOB DORANZ; Fiscal Year: 2011
    ....
  7. MULTIPLEXED VIRAL DETECTION IFA BY FLOW CYTOMETRY
    Daniel Collins; Fiscal Year: 2000
    ..Contamination by these pathogens is determined by the detection of viral antigens or anti-viral antibodies using EIA technology...
  8. SELECTIVE INDUCTION OF CTL-MEDIATED IMMUNITY
    Ralph Arlinghaus; Fiscal Year: 1992
    ..We propose that because of this "molecular mimicry" exhibited by HIV, the anti-viral antibodies may mask the incoming AIDS virus from immune system attack and even enhance virus infectivity through such ..
  9. Immunoproteomics and detection of viral diseases
    Michael Boyle; Fiscal Year: 2004
    ..we will develop and evaluate immunoproteomic assays to measure INF gamma (Th1 cytokine) and specific anti-viral antibodies in the serum of ectromelia infected mice...
  10. ANTI-HIV-1 ACTIVITY OF MANNAN-BINDING LECTIN
    Gregory Spear; Fiscal Year: 2003
    ..3. Utilize inhibitors of glycosylation to enhance biological effects of MBL. Exarnine the interaction of MBL with anti-viral antibodies in mediating anti-viral effects. Deterrnine the interaction of HIV-1 with MBL in vivo.
  11. ANIMAL ORAL PAPILLOMAVIRUS--MODEL FOR A VACCINE
    Richard Schlegel; Fiscal Year: 2000
    ..to assay COPV and HPV infectivity in-vitro so that it will be possible to inexpensively detect and titer anti-viral antibodies. In summary, the goals of this proposal are to define the molecular requirements for L1 immunogenicity and to ..
  12. CASE-CONTROL STUDY OF PRESENILE AND SENILE DEMENTIA
    Albert Heyman; Fiscal Year: 1980
    ..subjects by means of a structured epidemiologic interview, by analyses of serum and cerebrospinal fluid for viral antibodies and for increased concentrations of aluminum and other metallic ions and by detailed family history searching ..
  13. Transcripitonal and Genetic Profiles in HNSCCs
    Elaine Smith; Fiscal Year: 2008
    ..abstract_text> ..
  14. GENETIC EPIDEMIOLOGY AND MECHANISMS IN ORAL CANCER
    Elaine Smith; Fiscal Year: 2003
    ..abstract_text> ..
  15. International Collaborative HNC Research
    Elaine Smith; Fiscal Year: 2007
    ..This aim is to determine whether there is an easily administered, sensitive biomarker that can predict HPV-HR status in HNC tumors prior to therapy.. [unreadable] [unreadable] [unreadable]..
  16. Sixth International Respiratory Syncytial Virus Symposium
    ANN FALSEY; Fiscal Year: 2007
    ..abstract_text> ..
  17. Human Metapneumovirus in High Risk Populations
    Gregory Gray; Fiscal Year: 2005
    ..These data will facilitate the development of more comprehensive epidemiological studies, and guide future intervention studies in reducing HMPV morbidity. ..
  18. Population-based Surveillance for Zoonotic Influenza A
    Gregory Gray; Fiscal Year: 2005
    ..We are particularly well suited to conduct this work as we have extensive experience conducting both epidemiological and laboratory-based studies of respiratory pathogens. ..
  19. Human Metapneumovirus Infection in Adults
    ANN FALSEY; Fiscal Year: 2007
    ..abstract_text> ..
  20. Enhancement of targeting HIV vaccine to dendritic cell
    Sang Moo Kang; Fiscal Year: 2004
    ..As a long-term objective, the efficacy of targeting VLPs to DCs will be tested in a non-human primate model for designing a more effective AIDS vaccine. ..
  21. Effect of Male Circumcision on Penile HPV Infection
    JENNIFER SUSAN SMITH; Fiscal Year: 2010
    ..If male circumcision is found to be effective and safe in reducing HPV infection or penile lesions in men, it could in turn reduce HPV prevalence and associated cervical neoplasia in women. ..
  22. Remodeling SARS Coronavirus Genome Regulatory Networks
    Ralph Baric; Fiscal Year: 2004
    ..abstract_text> ..
  23. REVERSE GENETICS WITH A CORONAVIRUS INFECTIOUS CONSTRUCT
    Ralph Baric; Fiscal Year: 2004
    ..The assembly of a full-length TGE construct is an important breakthrough for coronavirus research and will benefit all aspects of coronavirus pathogenesis, molecular biology, epidemiology and biochemistry. ..
  24. SARS Reverse Genetics
    Ralph Baric; Fiscal Year: 2008
    ..The goal of this application is to establish genetic control over the SARS genome and provide uniform reagents that will be used by other groups throughout the country. ..
  25. Role of Immunization Site in Eliciting Mucosal Immunity
    Peter Anton; Fiscal Year: 2004
    ....
  26. Molecular Epidemiology of Fatal Prostate Cancer
    Sheila Weinmann; Fiscal Year: 2006
    ..The case-control study design will provide maximum statistical power for analysis of these relationships, particularly in the important African-American subgroup. ..
  27. ONTOGENY OF MEASLES IMMUNITY IN INFANTS
    Ann Arvin; Fiscal Year: 2006
    ..Understanding the maturation of host responses to viral antigens during the first year of life has general relevance for vaccine strategies in infancy. ..
  28. Gene therapy for chronic neurodegenerative disorders
    Maria Castro; Fiscal Year: 2006
    ..abstract_text> ..
  29. CHRYSTALLIZING DISULFIDE-STABILIZED HIV-1 ENV PROTEINS
    John Moore; Fiscal Year: 2004
    ..Any information accruing from the structure of a native Env trimer could facilitate the rational design of Env-based vaccines. ..
  30. ACUTE ALPHAVIRAL ENCEPHALITIS
    Diane Griffin; Fiscal Year: 2008
    ..abstract_text> ..
  31. Cellular Immune Responses Induced by SIVdelta-vif plus IL-15 DNA Vaccine
    Ellen Sparger; Fiscal Year: 2008
    ..Findings from these studies may then be used for future design for more effective HIV-1 vaccines, as well as design for immunotherapeutics for HIV-1 infection. [unreadable] [unreadable] [unreadable]..
  32. Immune Responses to CMV DNA Vaccination
    Mary Wloch; Fiscal Year: 2005
    ..Lastly, we will further the field of measurement of CMV neutralization, which will be critical in the area of maternal-fetal disease prevention and possible universal vaccination. ..
  33. VACCINE EFFICACY OF MODIFIED HIV ENVELOPES
    LEONIDAS A STAMATATOS; Fiscal Year: 2010
    ..abstract_text> ..
  34. Natural history of acute and chronic HCV in blood donors
    Michael Busch; Fiscal Year: 2008
    ..These investigations will yield important insights into HCV pathogenesis and clarify the natural history of disease for the large number of HCV infected persons identified through donor screening. ..
  35. VZV Receptors and Infective Mechanisms
    Anne Gershon; Fiscal Year: 2007
    ..It may also make it possible to develop a safer and more efficacious vaccine. ..
  36. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
    ....
  37. SELECTING ENV TRIMERS IN HIV-VLP VACCINE PRESENTATIONS
    James Binley; Fiscal Year: 2007
    ..In Specific Aim 3, we will test the immunogenicity of i) pseudovirions bearing only functional trimers and ii) receptor-engaged pseudovirions attached to autologous macaque lymphocytes. ..
  38. Receptor usage and pathogenicity of feline lentiviruses
    BRIAN WILLETT; Fiscal Year: 2007
    ..abstract_text> ..
  39. 2007 Viruses & Cells Gordon Conference
    Diane Griffin; Fiscal Year: 2007
    ..abstract_text> ..
  40. Towards Understanding the Morbidity of HEV Infection
    Mohamed Tarek Shata; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  41. Social and psychological risk for infectious illness
    Sheldon A Cohen; Fiscal Year: 2010
    ..abstract_text> ..
  42. Targeted Toxin for Brain Cancer Gene Therapy
    Maria Castro; Fiscal Year: 2008
    ..In summary, we expect to develop a targeted glioma gene therapy approach with high therapeutic efficacy and negligible toxicity which could be translated into clinical trials. [unreadable] [unreadable] [unreadable]..
  43. Vaccinia: T-cell immunity and homing to skin
    David Koelle; Fiscal Year: 2009
    ..Our data will assist in evaluating the immunogenicity of these constructs. ..
  44. Design and Use of HIV V3 Mimetic Immunogens
    Susan Zolla Pazner; Fiscal Year: 2008
    ..Finally, in Aim 3, we will examine how the intra- and inter-molecular interactions of gpl20 and gp41 affect neutralization sensitivity to anti-V3 mAbs. ..
  45. Mechanisms and clinical effects of microchimerism in transfused trauma patients
    MICHAEL PAUL BUSCH; Fiscal Year: 2010
    ..TA-MC also offers an opportunity to better understand, and potentially exploit, injury-induced tolerance for future therapeutic purposes. ..
  46. Early Regulation of Immunity in the Respiratory Tract
    Nicole Baumgarth; Fiscal Year: 2007
    ..This information could help the development of novel interventions that utilize early respiratory tract defenses for immune protection. [unreadable] [unreadable]..
  47. Immune Responses During Measles Virus Infection
    Diane Griffin; Fiscal Year: 2007
    ..3. To determine the roles of different CD4 and CD8 T cell populations in production of cytokines at various times during measles and the effect of concurrent HIV infection on these roles. ..
  48. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  49. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  50. Neighborhood, Race and Alcohol Use /Abuse Trajectories
    Stephen Buka; Fiscal Year: 2004
    ..In addition, this study will also support the development of advanced statistical techniques needed to simultaneously estimate school and neighborhood contributions to race/ethnic disparities in alcohol use. ..
  51. ENTRY INHIBITORS AS TOPICAL MICROBICIDES AGAINST HIV-1
    John Moore; Fiscal Year: 2004
    ..Moore, Ph.D., Fusion-Inhibitor Acquisition, Evaluation and Formulation; Administrative Core: John P. Moore, Ph.D. ..
  52. Inosine in the over-the-counter treatment of MS
    DOUGLAS HOOPER; Fiscal Year: 2004
    ..abstract_text> ..
  53. ACUTE INFECTION AND EARLY DISEASE RESEARCH NETWORK
    Joseph Margolick; Fiscal Year: 2003
    ..The data obtained will help define the optimal use of the new, potent therapies for HIV-1 infection, and will also help to understand the mechanism of immune system damage in HIV-l infection. ..
  54. Recombinant antibodies as an anti-microbial shield
    Alexander Pereboev; Fiscal Year: 2004
    ..To test the concept of a gene-therapy approach of the recAb anti-microbial defense in animal model. ..
  55. HUMAN MONOCLONAL ANTIBODIES THAT NEUTRALIZE VACCINIA
    James Crowe; Fiscal Year: 2002
    ..In summary, this work will yield a safe and effective immunotherapeutic strategy for treatment of vaccinia complications. ..
  56. HSV-SERONEGATIVE PERSONS WITH AQUIRED IMMUNITY TO HSV
    Christine Posavad; Fiscal Year: 2002
    ..abstract_text> ..
  57. DIETARY ETIOLOGIES OF MULTIPLE SCLEROSIS AND PARKINSONS
    Alberto Ascherio; Fiscal Year: 2001
    ..By the end of the follow-up, we project a total of 461 confirmed cases of MS and 380 confirmed cases of PD. We will have sufficient poser to evaluate a series of specific hypotheses with substantial public health implications. ..
  58. PRIMARY HHV6 INFECTION--CLINICAL & VIRAL CHARACTERISTICS
    Caroline Hall; Fiscal Year: 2001
    ..A matched subgroup of 180 (90 with seizures from HHV-6 and 90 with seizures not from HHV-6) will be compared for neurologic development after 3 years by neurologic examinations and standardized neuropsychologic testing. ..
  59. Human Resistance to Herpes Simplex Virus Infections
    Christine Posavad; Fiscal Year: 2005
    ..The data generated will be relevant to designing and evaluating strategies for HSV-2 preventative vaccines and immunotherapy. ..
  60. Cytokine-Augmented DNA Vaccine-Elicited Immunity to HIV
    DAN BAROUCH; Fiscal Year: 2005
    ..Raphael Dolin, Dean for Clinical Programs, Harvard Medical School, will guide Dr. Barouch's development as an independent investigator. In addition, a committee of distinguished scientists will oversee his progress toward independence. ..
  61. Cellular Immune Response to the SARS Human Coronavirus
    DANIEL LIBRATY; Fiscal Year: 2005
    ..Such studies will assess potential correlates of protective adaptive immunity to SARS HuCoV infection. ..
  62. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  63. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ....
  64. Cell-Mediated Immune Responses to Vaccinia Viruses
    James Crowe; Fiscal Year: 2006
    ..We will examine many of these questions by taking advantage of new technology that allows for examination of T cell responses at the single cell level, and in an immunodominant epitope specific manner. [unreadable] [unreadable]..
  65. IMPACT OF CO-RECEPTOR AND HIV VIRAL BURDEN ON GUT MUCOSA
    Peter Anton; Fiscal Year: 2004
    ..This will be done by looking for decreased mucosal viral burden and evidence of immune reconstitution after therapeutic intervention. ..
  66. Interaction between influenza virus and H. influenzae
    Sally Sarawar; Fiscal Year: 2007
    ..This could be particularly important during an influenza pandemic and may be more broadly applicable to other respiratory viruses. [unreadable] [unreadable] [unreadable]..
  67. Case/Cleveland Clinical Research Training Program (RMI)
    Richard Rudick; Fiscal Year: 2004
    ..It will host a national conference on this theme during 2007 to exchange "lessons learned" and evaluate how NIH-sponsored programs are measuring up to this strategic goal. ..
  68. Development of DNA Methyltransferase Inhibitors as Anti*
    Judy Mikovits; Fiscal Year: 2003
    ..We expect to develop small molecule inhibitors with acceptable efficacy and toxicity profiles for testing in animal models of human cancers. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  69. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT PROGRAM GCRC
    Richard Rudick; Fiscal Year: 2003
    ..The expected outcome of this construction project will be a centralized facility to conduct innovative, collaborative clinical research protocols and train a new generation of physician scientists. ..
  70. Case/Cleveland Clinic Clinical Research Training Program (RMI)
    Richard Rudick; Fiscal Year: 2007
    ..It will host a national conference on this theme during 2007 to exchange "lessons learned" and evaluate how NIH-sponsored programs are measuring up to this strategic goal. [unreadable] [unreadable]..
  71. ECOLOGY AND GENETICS OF VENEZUELAN EQUINE ENCEPHALITIS
    Scott Weaver; Fiscal Year: 2005
    ..This information will be invaluable in targeting prevention and control resources, especially for obtaining maximum benefit in developing countries with limited resources. ..
  72. Anal Dysplasia in HIV+ and HIV- men
    Timothy Wilkin; Fiscal Year: 2006
    ..This study will help provide important new information on which groups of HIV+ men may benefit from screening and how HAART may modify this risk. ..
  73. Chimeric Adenovirus Vaccine Vectors for HIV/SIV
    DAN BAROUCH; Fiscal Year: 2005
    ..Within the two-year time frame of this award, sufficient data will be generated with candidate chimeric rAd vaccines to justify further vaccine/challenge studies in rhesus monkeys. ..
  74. Augmentation of DNA Vaccine-Elicited Immunity to HIV/SIV
    DAN BAROUCH; Fiscal Year: 2008
    ..The long-term objectives of these studies are to develop novel vaccine regimens that recruit APCs to the site of inoculation in animal models and to consider advancing the most promising strategies into clinical trials. ..
  75. NEONATAL FC RECEPTOR/IGG INTERACTION
    PAMELA BJORKMAN; Fiscal Year: 2001
    ..5 to address the possibility of pH-dependent conformational changes. To answer the third question, mutants of FcRn with an open, MHC-like peptide-binding groove will be constructed and characterized. ..
  76. Pre-diagnostic markers of infection and risk of MS
    Alberto Ascherio; Fiscal Year: 2009
    ....
  77. Biodefense vaccine for pandemic influenza
    Lawrence Smith; Fiscal Year: 2005
    ..FINAL MILESTONE 3: Completion of Aim 2 and completion of IND ..