insulin antibodies

Summary

Summary: Antibodies specific to INSULIN.

Top Publications

  1. ncbi Higher prevalence of autoantibodies to insulin and GAD65 in Swedish compared to Lithuanian children with type 1 diabetes
    Hanna Holmberg
    Department of Molecular and Clinical Medicine, Clinical Research Center, Division of Pediatrics and Diabetes Research Centre, Faculty of Health Sciences, Linkopings Universitet, Sweden
    Diabetes Res Clin Pract 72:308-14. 2006
  2. pmc Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 34:1397-9. 2011
  3. pmc Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:179-86. 2012
  4. ncbi Characteristics of the antibodies of two patients who developed daytime hyperglycemia and morning hypoglycemia because of insulin antibodies
    Tsuneo Ishizuka
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Diabetes Res Clin Pract 84:e21-3. 2009
  5. ncbi Gestational diabetes identifies women at risk for permanent type 1 and type 2 diabetes in fertile age: predictive role of autoantibodies
    Ilkka Y Järvelä
    Department of Obstetrics and Gynecology, Oulu University Hospital, P O Box 5000, Oulu 90014, Finland
    Diabetes Care 29:607-12. 2006
  6. ncbi Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies
    M Schlosser
    Department of Medical Biochemistry and Molecular Biology, Research Group of Predictive Diagnostics, University of Greifswald, Greifswald, Germany
    Diabetologia 53:2611-20. 2010
  7. pmc Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status
    Bernice Lo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:203. 2011
  8. pmc Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 36:2266-70. 2013
  9. ncbi Screening for insulitis in adult autoantibody-positive organ donors
    Peter In't Veld
    Diabetes Research Center, Brussels Free University and Juvenile Diabetes Research Foundation Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
    Diabetes 56:2400-4. 2007
  10. pmc Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
    Peter Achenbach
    Institut fur Diabetesforschung, Kolner Platz 1, 80804 Munich, Germany
    J Clin Invest 114:589-97. 2004

Research Grants

  1. Preservation of Beta Cells by Glutamate Decarboxylase
    Diane Wherrett; Fiscal Year: 2007
  2. ENDOGENOUS AND EXOGENOUS INSULIN IN DIABETES MELLITUS
    David Horwitz; Fiscal Year: 1980
  3. GENETIC ORIGIN AND STRUCTURE OF INSULIN ANTIBODIES
    James Thomas; Fiscal Year: 2001
  4. HLA IN FAMILIES WITH IDD AND NIDD--DISTINCT SUBSET
    Miriam Segall; Fiscal Year: 1992
  5. International Congress of the Immunology of Diabetes Soc
    George Eisenbarth; Fiscal Year: 2002
  6. Antibodies to Recombinant Autoantigens: Prediction
    George Eisenbarth; Fiscal Year: 2004
  7. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2008
  8. GENE ENVIRONMENT STUDY OF TYPE 2 DIABETES IN FAMILIES
    Jill Norris; Fiscal Year: 2002
  9. Chromium and Insulin Action
    William Cefalu; Fiscal Year: 2006
  10. Analgesic tolerance to mu-delta opioid bivalent ligands
    NATALIE LENARD; Fiscal Year: 2006

Detail Information

Publications205 found, 100 shown here

  1. ncbi Higher prevalence of autoantibodies to insulin and GAD65 in Swedish compared to Lithuanian children with type 1 diabetes
    Hanna Holmberg
    Department of Molecular and Clinical Medicine, Clinical Research Center, Division of Pediatrics and Diabetes Research Centre, Faculty of Health Sciences, Linkopings Universitet, Sweden
    Diabetes Res Clin Pract 72:308-14. 2006
    ..Furthermore, the disease in patients with insulin autoantibodies seems to be clinically milder...
  2. pmc Age of islet autoantibody appearance and mean levels of insulin, but not GAD or IA-2 autoantibodies, predict age of diagnosis of type 1 diabetes: diabetes autoimmunity study in the young
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 34:1397-9. 2011
    ..We evaluated predictors of progression to diabetes in children with high-risk HLA genotypes and persistent islet autoantibodies...
  3. pmc Distinguishing persistent insulin autoantibodies with differential risk: nonradioactive bivalent proinsulin/insulin autoantibody assay
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:179-86. 2012
    ..We hypothesize that factors related to the mechanism of loss of tolerance leading to diabetes determine high affinity and MSD-IAA reactivity...
  4. ncbi Characteristics of the antibodies of two patients who developed daytime hyperglycemia and morning hypoglycemia because of insulin antibodies
    Tsuneo Ishizuka
    Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University School of Medicine, 1 1 Seiryo cho, Aoba ku, Sendai 980 8574, Japan
    Diabetes Res Clin Pract 84:e21-3. 2009
    ....
  5. ncbi Gestational diabetes identifies women at risk for permanent type 1 and type 2 diabetes in fertile age: predictive role of autoantibodies
    Ilkka Y Järvelä
    Department of Obstetrics and Gynecology, Oulu University Hospital, P O Box 5000, Oulu 90014, Finland
    Diabetes Care 29:607-12. 2006
    ..Our aim was to evaluate the predictive value of gestational diabetes mellitus (GDM), diabetes-associated autoantibodies, and other factors for development of clinical diabetes later in life...
  6. ncbi Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies
    M Schlosser
    Department of Medical Biochemistry and Molecular Biology, Research Group of Predictive Diagnostics, University of Greifswald, Greifswald, Germany
    Diabetologia 53:2611-20. 2010
    ..The Diabetes Antibody Standardization Program (DASP) aims to improve and standardise measurement of autoantibodies associated with type 1 diabetes. We report the results of measurement of IAA from DASP workshops in 2002, 2003 and 2005...
  7. pmc Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status
    Bernice Lo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:203. 2011
    ..Therefore, a rapid, non-radioactive, and reproducible assay is highly desirable...
  8. pmc Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity
    Liping Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes Care 36:2266-70. 2013
    ..We evaluated a novel electrochemiluminescent assay for insulin/proinsulin autoantibodies (ECL-IAA) as a new marker of the onset of islet autoimmunity and as a predictor of type 1 diabetes...
  9. ncbi Screening for insulitis in adult autoantibody-positive organ donors
    Peter In't Veld
    Diabetes Research Center, Brussels Free University and Juvenile Diabetes Research Foundation Center for Beta Cell Therapy in Diabetes, Brussels, Belgium
    Diabetes 56:2400-4. 2007
    ..It was only detected in <10% of the islets, some of which presented signs of beta-cell proliferation. No decrease in beta-cell mass was detected in cases with insulitis or in the group of antibody+ subjects...
  10. pmc Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
    Peter Achenbach
    Institut fur Diabetesforschung, Kolner Platz 1, 80804 Munich, Germany
    J Clin Invest 114:589-97. 2004
    ....
  11. ncbi Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk
    P Achenbach
    Diabetes Research Institute of Forschergruppe Diabetes e V, Helmholtz Center Munich, Ingolstaedter Landstr 1, 85764, Neuherberg, Germany
    Diabetologia 52:1881-8. 2009
    ..Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk...
  12. ncbi Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic mice
    David T Robles
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
    Diabetes 52:882-6. 2003
    ..It is likely that patients with type 1 diabetes will also show non-major histocompatibility complex genetically determined variation in expression of autoantibodies and progression to diabetes...
  13. ncbi Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population
    T Kimpimäki
    The Juvenile Diabetes Research Foundation Center for Type 1 Diabetes Prevention in Finland, Department of Pediatrics, Medical School, University of Tampere and Tampere University Hospital, FIN 33014 Tampere
    J Clin Endocrinol Metab 87:4572-9. 2002
    ....
  14. ncbi Long-term prevention of diabetes and marked suppression of insulin autoantibodies and insulitis in mice lacking native insulin B9-23 sequence
    M Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, Aurora, CO 80045, USA
    Ann N Y Acad Sci 1079:122-9. 2006
    ..In contrast to mice with at least one copy of a native insulin gene that expressed insulin antibodies, only 2 out of 21 (10%) double native insulin gene knockout mice with a mutated insulin transgene developed ..
  15. ncbi Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population
    M Kukko
    Juvenile Diabetes Research Foundation Center for the Prevention of Type 1 Diabetes in Finland and Medical School, University of Tampere, and Department of Pediatrics, Tampere University Hospital
    J Clin Endocrinol Metab 90:2712-7. 2005
    This study characterized the dynamics of islet cell antibodies (ICA), insulin antibodies (IAA), glutamic acid decarboxylase antibodies (GADA), and IA-2 antibodies (IA-2A) in 1006 children recruited from the general population due to human ..
  16. pmc Murine high specificity/sensitivity competitive europium insulin autoantibody assay
    Naru Babaya
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado 80045 6511, USA
    Diabetes Technol Ther 11:227-33. 2009
    ..There is thus a need for simpler assay formats that do not utilize radioactivity, yet retain the high specificity and sensitivity of radioassays...
  17. ncbi Insulin assays: previously known and new analytical features
    Remy Sapin
    Unite d Analyses Endocriniennes, Institut de Physique Biologique, CNRS ULP UMR 7004, Faculte de Medecine, Strasbourg, France
    Clin Lab 49:113-21. 2003
    ..The specificity of human insulin assays to these analogues should be assessed. Anti-insulin antibodies are present in a significant proportion of sera to be analyzed for insulin...
  18. ncbi Early and quantal (by litter) expression of insulin autoantibodies in the nonobese diabetic mice predict early diabetes onset
    Evie Melanitou
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 173:6603-10. 2004
    ..Pathological progression to autoimmunity is marked by the presence of immunological windows relating early steps with final disease onset...
  19. ncbi Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics
    Peter Achenbach
    Diabetes Research Institute and 3rd Medical Department, Hospital München Schwabing, Munich, Germany
    Diabetes 53:384-92. 2004
    ..Using models based on these antibody characteristics, autoantibody-positive relatives can be classified into groups with risks of diabetes ranging from 7 to 89% within 5 years...
  20. ncbi Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes
    Leonard C Harrison
    Autoimmunity and Transplantation Division, The WalterEliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3050, Victoria, Australia
    Diabetes Care 27:2348-55. 2004
    ....
  21. ncbi Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial. Diabète Insuline Orale group
    L Chaillous
    Centres Hospitaliers Universitaires de Nantes, France
    Lancet 356:545-9. 2000
    ..We investigated whether oral administration of recombinant human insulin could protect residual beta-cell function in recent-onset type 1 diabetes...
  22. ncbi Severe insulin resistance secondary to insulin antibodies: successful treatment with the immunosuppressant MMF
    T Segal
    Department of Paediatric and Adolescent Endocrinology, University College Hospital, London, UK
    Pediatr Diabetes 9:250-4. 2008
    ..mycophenolate mofetil (MMF) in the treatment of severe insulin resistance caused by neutralising anti-insulin antibodies in type 1 diabetes mellitus (T1DM)...
  23. ncbi Role of insulin autoantibody affinity as a predictive marker for type 1 diabetes in young children with HLA-conferred disease susceptibility
    Heli Siljander
    Hospital for Children and Adolescents and Folkhälsan Research Center, University of Helsinki, 00014 Helsinki, Finland
    Diabetes Metab Res Rev 25:615-22. 2009
    ....
  24. ncbi The use of phage display to distinguish insulin autoantibody (IAA) from insulin antibody (IA) idiotypes
    D Devendra
    Department of University Medicine, Plymouth Campus, United Kingdom
    Diabetologia 46:802-9. 2003
    Radiobinding assays (RBA) are unable to differentiate insulin autoantibodies (IAA) from insulin antibodies (IA)...
  25. ncbi Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization Program
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, 80804 Munich, Germany
    Clin Immunol 122:85-90. 2007
    ..This workshop has demonstrated that different laboratories are able to reproduce IAA affinity results and that considering IAA affinity is likely to improve the diagnostic performance of IAA assays...
  26. ncbi Impact of insulin antibodies on insulin aspart pharmacokinetics and pharmacodynamics after 12-week treatment with multiple daily injections of biphasic insulin aspart 30 in patients with type 1 diabetes
    J W Chen
    Department of Endocrinology and Diabetes and Medical Research Laboratories, Aarhus University Hospital, Norrebrogade 44, DK 8000, Aarhus C, Denmark
    Eur J Endocrinol 153:907-13. 2005
    This study aimed to evaluate the impact of insulin antibodies on insulin aspart pharmaco-kinetics and pharmacodynamics after 12-week multiple daily injections of biphasic insulin aspart 30 (30% fast-acting and 70% protamine-crystallised ..
  27. ncbi Diabetes Antibody Standardization Program: first assay proficiency evaluation
    Polly J Bingley
    Division of Medicine, Medical School Unit, University of Bristol, Southmead Hospital, Bristol BS10 5NB, U K
    Diabetes 52:1128-36. 2003
    ..Differences in assay protocols between laboratories must be addressed so that all centers and kit manufacturers can perform to the same high standard...
  28. ncbi Identification of insulin autoantibodies of IgA isotype that preferentially target non-human insulin
    Kerstin Koczwara
    Diabetes Research Institute, Munich, Germany
    Clin Immunol 124:77-82. 2007
    ..The findings suggest that some IAA can result from immunization against molecules other than human insulin at mucosal sites...
  29. ncbi Characterization of the humoral immune response to islet antigen 2 in children with newly diagnosed type 1 diabetes
    Anna Mäkinen
    Scientific Laboratory, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Biomedicum I, PO Box 63, FI 00014 Helsinki, Finland
    Eur J Endocrinol 159:19-26. 2008
    ....
  30. ncbi The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity
    Robert Hermann
    JDRF Centre for Prevention of Type 1 Diabetes in Finland, Turku, Finland
    Diabetologia 48:1766-75. 2005
    ..The aim of this study was to explore the contribution of genetic factors to the emergence of beta-cell-specific humoral autoimmunity...
  31. doi Evaluation of insulin antibodies and placental transfer of insulin aspart in pregnant women with type 1 diabetes mellitus
    D R McCance
    Diabetologia 51:2141-3. 2008
  32. ncbi The effect of insulin antibodies on the metabolic action of inhaled and subcutaneous insulin: a prospective randomized pharmacodynamic study
    Tim Heise
    Profil Institut für Stoffwechselforschung, Hellersbergstr 9, D 41460 Neuss, Germany
    Diabetes Care 28:2161-9. 2005
    To assess the impact of the development of high- or low-affinity insulin antibodies (IABs) on postprandial glucose tolerance, duration of insulin action, and clinical safety in patients with type 1 diabetes receiving inhaled insulin (..
  33. ncbi Low prevalence of islet autoantibodies in patients with gestational diabetes mellitus
    N Dozio
    Department of Medicine, H San Raffaele Scientific Institute, University of Milano, Italy
    Diabetes Care 20:81-3. 1997
    ..To determine the proportion of patients with gestational diabetes mellitus (GDM) who have serological characteristics typical of IDDM...
  34. ncbi Circulating insulin antibodies: influence of continuous subcutaneous or intraperitoneal insulin infusion, and impact on glucose control
    R P Radermecker
    Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Liege, University of Liege, Liege, Belgium
    Diabetes Metab Res Rev 25:491-501. 2009
    ..insulin have markedly reduced the incidence, but not completely suppressed, the development of anti-insulin antibodies (IAs). Advances in technologies concerning the mode of delivery of insulin, i.e...
  35. ncbi [The study of two immunological markers in patients with type-1 diabetes and in their first degree relatives]
    Adriana Cosmescu
    Universitatea de Medicină si Farmacie Gr T Popa Iaşi, Facultatea de Medicina, Disciplina Medicină Generală Medicină de Familie copii
    Rev Med Chir Soc Med Nat Iasi 108:549-53. 2004
    ..CONCLUSION: The use of plasma markers is recommended as a first step in discovering the relatives with potential risk of developing the disease...
  36. ncbi Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells
    M Bridgett
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Diabetes 47:1848-56. 1998
    ..Quantitative differences in expression level or insertional mutagenesis are possible mechanisms of protection in the A line...
  37. ncbi Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies
    Anette G Ziegler
    Diabetes Research Institute and Hospital München Schwabing, Munich, Germany
    JAMA 290:1721-8. 2003
    ..Dietary factors modifying type 1 diabetes mellitus (DM) risk have been proposed, but little is known if they trigger the islet autoimmunity that precedes clinical disease...
  38. ncbi Progression of autoimmune diabetes: slowly progressive insulin-dependent diabetes mellitus or latent autoimmune diabetes of adult
    Huriya Beyan
    Institute of Cell and Molecular Science, Centre for Diabetes and Metabolic Medicine, Bart s and The London, Queen Mary s School of Medicine and Dentistry, 4 Newark Street, London, UK
    Ann N Y Acad Sci 1079:81-9. 2006
    ....
  39. ncbi Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes
    George S Eisenbarth
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, CO 80262, USA
    Autoimmun Rev 1:139-45. 2002
    ..An expanding set of resources are now available for the development and testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin peptides are now underway...
  40. ncbi Pancreatic autoantibodies in Italian patients with newly diagnosed type 1 diabetes mellitus over the age of 20 years
    C Betterle
    Division of Endocrinology, Department of Medical and Surgical Sciences, University of Padua, Italy
    Acta Diabetol 43:79-83. 2006
    ..The best cost/benefit combination is provided by coupling the detection of GADA and ICA...
  41. ncbi Islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes from Sri Lanka
    L D K E Premawardhana
    Department of Medicine, Caerphilly Miners Hospital, Caerphilly, UK
    J Endocrinol Invest 29:968-74. 2006
    ..The prevalence of islet cell, thyroid, adrenal and celiac disease related autoantibodies in patients with Type 1 diabetes mellitus (Type 1 DM) from Sri Lanka is described...
  42. pmc Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus
    Bo Niklasson
    Apodemus AB, Stockholm, Sweden
    Int J Exp Diabesity Res 4:35-44. 2003
    ..It is speculated that bank voles may have a possible zoonotic role as a reservoir and vector for virus that may contribute to the incidence of type 1 diabetes in humans...
  43. ncbi Islet autoantibodies are associated with HLA-DQ genotypes in Han Chinese patients with type 1 diabetes and their relatives
    J P Wang
    Department of Endocrinology, Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Tissue Antigens 70:369-75. 2007
    ..The findings in the study indicate that some of specific HLA-DQA1/-DQB1 genotypes and haplotypes not only confer susceptibility to T1D but also are associated with the presence of the islet autoantibodies in the Han Chinese population...
  44. pmc Longitudinal epitope analysis of insulin-binding antibodies in type 1 diabetes
    T R Hall
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Exp Immunol 146:9-14. 2006
    ..We hypothesize that insulin antibodies (IA) that develop upon initiation of insulin treatment differ in their epitope specificities from IAA...
  45. ncbi Dermal enhancement: bacterial products on intact skin induce and augment organ-specific autoimmune disease
    D Sean Riminton
    Comparative Genomics Centre, James Cook University, Townsville, Queensland 4811, Australia
    J Immunol 172:302-9. 2004
    ....
  46. ncbi Transmission of maternal islet antibodies and risk of autoimmune diabetes in offspring of mothers with type 1 diabetes
    Kerstin Koczwara
    Diabetes Research Institute and 3rd Medical Department, Krankenhaus München Schwabing, Munich, Germany
    Diabetes 53:1-4. 2004
    ..These findings suggest that fetal exposure to islet autoantibodies in children born to mothers with type 1 diabetes may be protective against future islet autoimmunity and diabetes...
  47. pmc Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein
    D Elias
    Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel
    Proc Natl Acad Sci U S A 87:1576-80. 1990
    ..becomes detectable in the sera of the prediabetic mice and some weeks later anti-hsp65 antibodies, anti-insulin antibodies, and anti-idiotypic antibodies to insulin antibodies become detectable...
  48. pmc Epitope analysis of insulin autoantibodies using recombinant Fab
    C J Padoa
    Department of Chemical Pathology, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa
    Clin Exp Immunol 140:564-71. 2005
    ..0001). We conclude that competition between insulin-specific monoclonal antibodies or their recombinant Fab and insulin autoantibodies should prove useful in the epitope analysis of autoantibodies to insulin...
  49. ncbi [Factors affecting C-peptide level during the first year of type 1 diabetes in children]
    Agnieszka Zmysłowska
    Klinika Chorób Dzieci Instytutu Pediatrii UM w Łodzi, Łódź, Poland
    Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw 10:103-11. 2004
    ..C-peptide level is the most reliable factor evaluating the endogenous insulin secretion in patients with type 1 diabetes...
  50. ncbi Autoantibodies to insulin and to proinsulin in type 1 diabetic patients and in at-risk probands differentiate only little between both antigens
    H Keilacker
    , , Karlsburg, Germany
    Horm Metab Res 27:90-4. 1995
    ..nor are insulin autoantibodies merely a subgroup of proinsulin autoantibodies: In each group, in the mean, insulin antibodies as well as proinsulin antibodies reacted somewhat (but significantly) stronger with their respective antigen...
  51. ncbi Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouse
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B140, Denver, CO 80262, USA
    J Autoimmun 21:213-9. 2003
    ..Furthermore, recent experience has demonstrated the potential dangers of disease exacerbation or anaphylaxis with peptide immunotherapy...
  52. ncbi Clinical and immunological characteristics of type 1 diabetes mellitus in a northwestern Colombian population
    G J Tobon
    Cellular Biology and Immunogenetics Unit, Corporacion para Investigaciones Biologicas, Cra 72 A No 78 B 141, Medellin, Colombia
    Diabetes Res Clin Pract 72:170-5. 2006
    ..Glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A) and insulin antibodies (IAA) were examined by radioimmunoassay. There were 107 patients with T1D. Male:female ratio was 1:1...
  53. ncbi Delayed exposure to wheat and barley proteins reduces diabetes incidence in non-obese diabetic mice
    Sandra Schmid
    Diabetes Research Institute, Krankenhaus München Schwabing, Munich, Germany
    Clin Immunol 111:108-18. 2004
    ..These data support a link between dietary wheat and barley proteins and the development of autoimmune diabetes...
  54. ncbi Diabetes therapy trials with inhaled insulin
    Samuel Edwin Fineberg
    Indiana University School of Medicine, 1120 South Drive, Fesler Hall 302, Indianapolis, USA
    Expert Opin Investig Drugs 15:743-62. 2006
    ..However, all systems successfully deliver insulin to the deep lung and biological effectiveness compares favourably with injected subcutaneous insulins...
  55. ncbi Clinical, autoimmune, and HLA characteristics of children diagnosed with type 1 diabetes before 5 years of age
    Eba H Hathout
    Pediatric Diabetes Center and Transplant Immunology Center, Loma Linda University Children s Hospital, Loma Linda, California 92354, USA
    Pediatrics 111:860-3. 2003
    ..HLA subtypes have been shown to play an important part in the determination of islet-cell autoimmunity and in the pace and intensity of the beta-cell destructive process...
  56. ncbi Improved glycaemic control with the use of self-prepared mixtures of insulin lispro and insulin lispro protamine suspension in patients with types 1 and 2 diabetes
    P Roach
    Lilly Research Laboratories, Eli Lilly and Company, DC2042, Indianapolis, IN 46285, USA
    Int J Clin Pract 55:177-82. 2001
    ..54 +/- 0.11% vs 7.92 +/- 0.10%, p = 0.019). There was no difference in hypoglycaemia or insulin antibody levels. LP/NPL resulted in better glycaemic control than HR/NPH without increasing the risk of hypoglycaemia...
  57. ncbi Expression of GAD65 and islet cell antibody (ICA512) autoantibodies among cytoplasmic ICA+ relatives is associated with eligibility for the Diabetes Prevention Trial-Type 1
    L Yu
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Denver, Colorado 80262, USA
    Diabetes 50:1735-40. 2001
    ..Positivity for biochemically determined autoantibodies among cytoplasmic antibody-positive relatives is associated with eligibility for the DPT-1 study...
  58. ncbi [Relationship between autoantibodies and HLA-DQ genotypes in patients with type 1 diabetes mellitus]
    Jian Ping Wang
    Department of Endocrinology and Metabolism, Second Xiangya Hospital, Diabetes Center, Institute of Metabolism and Endocrinology, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 87:2380-4. 2007
    ..e., glutamic acid decarboxylase antibody (GADA), protein-tyrosine-phosphatase-2 autoantibody (IA-2A), and insulin autoantibody (IAA), and human leukocyte HLA-DQ genotypes in the patients with type 1 diabetes mellitus (T1DM)...
  59. ncbi Endocrine autoimmunity in young patients with juvenile chronic arthritis
    M G Alpigiani
    Department of Pediatrics, University of Genoa, G Gaslini Institute, Italy
    Clin Exp Rheumatol 20:565-8. 2002
    ..The aim of our study was to investigate the coexistence of autoimmune diseases (autoimmune thyroid disease and type 1 diabetes mellitus, T1DM) in patients affected by Juvenile Chronic Arthritis (JCA)...
  60. ncbi Transient insulin autoantibody expression independent of development of diabetes: comparison of NOD and NOR strains
    N Abiru
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    J Autoimmun 17:1-6. 2001
    ..In addition, this data is not consistent with the hypothesis that the time-course of autoantibodies simply reflects the destruction of beta-cells with development of diabetes...
  61. ncbi GAD65 and ICA512 antibodies in undernourished and normally nourished south Indian patients with diabetes
    A K Das
    Department of Medicine, JIPMER, Pondicherry, India
    Ann N Y Acad Sci 958:247-50. 2002
    ..In conclusion, undernutrition does not predispose to autoimmunity in south Indian diabetic patients...
  62. ncbi Autoantibodies in children with type 2 diabetes mellitus
    Vatcharapan Umpaichitra
    Department of Pediatrics, State University of New York Health Science Center at Brooklyn, 11203, USA
    J Pediatr Endocrinol Metab 15:525-30. 2002
    ..Thus, low (10.8%) frequency of autoimmunity in children and adolescents is consistent with their clinical classification of type 2 DM based on the presence of residual C-peptide...
  63. ncbi Screening of diabetes, thyroid, and celiac diseases-related autoantibodies in a sample of Turkish children with type 1 diabetes and their siblings
    Gulay Karaguzel
    Karadeniz Technical University, School of Medicine, Department of Pediatrics, Division of Pediatric Endocrinology, Trabzon, Turkey
    Diabetes Res Clin Pract 80:238-43. 2008
    ..The purpose of this study was to investigate the presence of diabetes, thyroid, and celiac diseases (CD)-related autoantibodies in children with type 1 diabetes (DM1) and their siblings...
  64. ncbi Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes
    K Decochez
    Diabetes Research Center, Brussels Free University VUB, Laarbeeklaan 103, 1090 Brussels, Belgium
    Diabetologia 48:687-94. 2005
    ..We investigated whether specific combinations of immune and genetic markers can identify subgroups with more homogeneous progression to clinical onset...
  65. ncbi Progression to insulin-requiring diabetes in seronegative prediabetic subjects: the role of two HLA-DQ high-risk haplotypes
    M Pietropaolo
    Division of Immunogenetics, Rangos Research Center, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3460 Fifth Avenue, Pittsburgh, PA 15213, USA
    Diabetologia 45:66-76. 2002
    ....
  66. ncbi Seasonality of month of birth differs between type 1 diabetes patients with pronounced beta-cell autoimmunity and individuals with lesser or no beta-cell autoimmunity
    Hadas Lewy
    Schneider Children s Medical Center of Israel, Petah Tikva, Israel
    Pediatr Diabetes 9:46-52. 2008
    ....
  67. ncbi IA-2 autoantibodies predict impending type I diabetes in siblings of patients
    K Decochez
    Diabetes Research Centre, Free University of Brussels, Belgium
    Diabetologia 45:1658-66. 2002
    ..We compared its predictive value with that of positivity for a particular type of islet autoantibody, directed against the IA-2 antigen...
  68. ncbi Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes
    Jeffrey P Krischer
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612 9497, USA
    J Clin Endocrinol Metab 88:103-8. 2003
    ..Further follow-up and analysis of actual progression to diabetes will be essential to define actual diabetes risk in this large cohort...
  69. ncbi Peptide-specific cytotoxicity of T lymphocytes against glutamic acid decarboxylase and insulin in type 1 diabetes mellitus
    K Kimura
    Department of Pediatrics, Osaka City University Graduate School of Medicine, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
    Diabetes Res Clin Pract 51:173-9. 2001
    ..None of healthy controls showed cytotoxicity against GAD or insulin peptides was observed. This is the first report describing the cytotoxic activity of CD8+ T lymphocytes against insulin in type 1 DM...
  70. ncbi Glycaemic control and antibody status among patients with newly diagnosed Type 1 diabetes
    Doron Hickey
    University of Auckland, Auckland
    N Z Med J 120:U2732. 2007
    ..To compare the risk of admission to hospital and poor glycaemic control by antibody status among newly diagnosed patients with type 1 diabetes in the Waikato Province of New Zealand...
  71. ncbi First-phase insulin response in young healthy children at genetic and immunological risk for Type I diabetes
    P Keskinen
    The JDRF Center for Prevention of Type I Diabetes in Finland
    Diabetologia 45:1639-48. 2002
    ..We studied the first-phase insulin responses of small children soon after observed seroconversion to autoantibody positivity...
  72. ncbi Biotin increases glucokinase expression via soluble guanylate cyclase/protein kinase G, adenosine triphosphate production and autocrine action of insulin in pancreatic rat islets
    Alonso Vilches-Flores
    Unidad de Genetica de la Nutricion, Instituto de Investigaciones Biomedicas, Universidad Nacional Autónoma de México Instituto Nacional de Pediatría, Mexico City, C P 04530, Mexico
    J Nutr Biochem 21:606-12. 2010
    ..62+/-0.26 pmol/islet) at 30 min. Inhibition of PKG activity suppressed the effects of biotin on ATP content. Insulin antibodies or inhibitors of phosphoinositol-3-kinase/Akt insulin signalling pathway prevented biotin-induced ..
  73. ncbi Hypoglycemia after pancreas transplantation
    J B Redmon
    Department of Medicine, The University of Minnesota, Minneapolis 55455, USA
    Diabetes Care 21:1944-50. 1998
    ..Therefore, we studied glucose and hormone levels in transplant recipients and healthy control subjects...
  74. ncbi Non-islet-cell tumor hypoglycemia and lactic acidosis in a child with congenital HIV and Burkitt's lymphoma
    Maynika V Rastogi
    King s County Hospital Center and Children s Hospital at Downstate, SUNY Downstate Medical Center, Brooklyn, NY, USA
    J Pediatr Endocrinol Metab 21:805-10. 2008
    ..Most cases of NICTH and lactic acidosis have been described in the adult population. We report a child with congenital HIV and AIDS who developed Burkitt's lymphoma, lactic acidosis and NICTH...
  75. ncbi A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies. Osaka IDDM Study Group
    A Imagawa
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    N Engl J Med 342:301-7. 2000
    ....
  76. ncbi Use of insulin immunoassays in clinical studies involving rapid-acting insulin analogues: Bi-insulin IRMA preliminary assessment
    Arnaud Agin
    Faculte de Medecine, Universite Louis Pasteur, Centre National de la Recherche Scientifique, Unité Mixte de recherche 7004, Institut de Physique Biologique, Strasbourg, France
    Clin Chem Lab Med 44:1379-82. 2006
    ..human insulin immunoassays have been widely used, but their limitations (including hemolysis and anti-insulin antibodies) were not fully investigated...
  77. ncbi Inhaled insulin for the treatment of diabetes: projects and devices
    Jean Louis Selam
    Diabetes Research Center, 2492 Walnut Ave, Tustin, CA 92780, USA
    Expert Opin Pharmacother 4:1373-7. 2003
    ..The inhaled insulin group developed increased insulin antibodies. A total of 25% of the patients experienced cough after inhalation...
  78. ncbi Two-color electrophoretic immunoassay for simultaneous measurement of insulin and glucagon content in islets of Langerhans
    Christelle Guillo
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL, USA
    Electrophoresis 29:410-6. 2008
    ..Insulin was quantified with FITC-insulin (Ins*) and anti-insulin antibodies (Ins Ab) and glucagon was quantified with Cy5-glucagon (Glu*) and anti-glucagon antibodies (Glu Ab)...
  79. ncbi Insulin antibodies are associated with lipoatrophy but also with lipohypertrophy in children and adolescents with type 1 diabetes
    K Raile
    Children s Hospital, Ludwig Maximilians University of Munich, Munich, Germany
    Exp Clin Endocrinol Diabetes 109:393-6. 2001
    ..To evaluate clinical and immunological factors that are associated with lipodystrophy, i.e. lipoatrophy and lipohypertrophy, in diabetic children and adolescents...
  80. ncbi Burkitt's lymphoma presenting with lactic acidosis and hypoglycemia - a case presentation
    Jeffrey J Glasheen
    Division of General Internal Medicine, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Leuk Lymphoma 46:281-3. 2005
    ..Serum insulin, proinsulin and C-peptide levels were normal and insulin antibodies were negative. Insulin-like growth factors I and II were low, while thyroid and cortisol studies were normal...
  81. ncbi [Transitory neonatal diabetes]
    J Carretero Bellón
    Unidad de Neonatologia, Servicio de Pediatria, Hospital Universitario Juan XXIII, Tarragona
    An Esp Pediatr 54:394-6. 2001
    ..During this time concentrations of insulin, cortisone, peptide C, insulin antibodies, anti-TPO, anti-TG, anti-GAD, anti-tyrosine-phosphatase and glycosylate hemoglobin were normal...
  82. ncbi Metabolic and immunologic effects of insulin lispro in gestational diabetes
    L Jovanovic
    Sansum Medical Research Institute, Santa Barbara, California 93105, USA
    Diabetes Care 22:1422-7. 1999
    ..To compare the immunologic response to insulin lispro with that to regular human insulin, thereby assuring its safety for use in women with gestational diabetes, and to verify that it is effective...
  83. ncbi Early administration of an immunomodulator and induction of remission in insulin-dependent diabetes mellitus
    C Giordano
    Laboratory of Immunology, School of Medicine, University of Palermo, Italy
    J Autoimmun 3:611-7. 1990
    ..A reduction in anti-insulin antibodies (AIA) in Thy-treated patients was observed in comparison to conventionally treated IDDM starting from 6 ..
  84. ncbi [Diabetic ketoacidosis responsive to methotrexate in a patient with a mixed connective tissue disease]
    Victoria Novik A
    Cátedra de Medicina, Facultad de Medicina, Universidad de Valparaiso, Viña del Mar Alto, Chile
    Rev Med Chil 135:87-91. 2007
    ..Anti insulin antibodies were not detected and anti islet antibodies were indeterminate, due to interference with antinuclear ..
  85. ncbi A case of insulin-induced localized lobular panniculitis with evidence for the phagocytosis of insulin by histiocytes
    Ikki Shimizu
    Department of Diabetes and Endocrinology, Ehime Prefectural Central Hospital, Matsuyama, Japan
    Endocr J 54:477-80. 2007
    ..Thus, the phagocytosis of insulin by histiocytes appears to occur in this region. Therefore, the activation of subcutaneous macrophages by the complex of insulin and insulin antibodies may account for the initial autoimmune process.
  86. ncbi Chitosan-polyvinyl pyrrolidone hydrogels as candidate for islet immunoisolation: in vitro biocompatibility evaluation
    M Risbud
    Tissue Engineering and Banking Laboratory, National Centre for Cell Science, Pune, India
    Cell Transplant 9:25-31. 2000
    ..M1 allowed regulated transport of insulin and did not allow anti-insulin antibodies to pass through...
  87. ncbi Camel milk as an adjuvant therapy for the treatment of type 1 diabetes: verification of a traditional ethnomedical practice
    Ragaa Hosny Mohamad
    Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    J Med Food 12:461-5. 2009
    ..baseline and at 4 and 16 weeks: hemoglobin A1c (HbA1c), human C-peptide, lipid profile, serum insulin, anti-insulin antibodies, creatinine clearance, albumin in 24-hour urine, body mass index, and Diabetes Quality of Life score...
  88. ncbi Efficacy and safety of insulin glulisine in Japanese patients with type 1 diabetes mellitus
    R Kawamori
    Department of Medicine, Metabolism and Endocrinology, School of Medicine, Juntendo University, Tokyo, Japan
    Diabetes Obes Metab 11:891-9. 2009
    ..The rapid-acting insulin analogue insulin glulisine (glulisine) was compared with insulin lispro (lispro) for efficacy and safety in Japanese patients with type 1 diabetes mellitus (T1DM), using insulin glargine (glargine) as basal insulin...
  89. ncbi In vitro insulin production and analysis of pancreatic transcription factors in induced human hepatic progenitor cells
    Aleem A Khan
    Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, India
    Diabetes Technol Ther 12:373-8. 2010
    ..Hence, the present study was designed to analyze the feasibility of using primary human fetal hepatic progenitors as a potential source for insulin production...
  90. ncbi Intra-arterial liver chemotherapy and hormone therapy in malignant insulinoma: case report and review of the literature
    L Moscetti
    Department of Experimental Medicine, University La Sapienza, Policlinico Umberto I, Rome, Italy
    Tumori 86:475-9. 2000
    ..who developed liver metastases twelve years following resection of a pancreatic insulinoma positive to anti-insulin antibodies. With five cycles of intra-arterial locoregional chemotherapy (fluorouracil and epirubicin) to the liver and ..
  91. ncbi Immunological responses to exogenous insulin
    S Edwin Fineberg
    Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Endocr Rev 28:625-52. 2007
    ..Little proof exists, however, that the development of insulin antibodies (IAs) to exogenous insulin therapy affects integrated glucose control, insulin dose requirements, and ..
  92. ncbi Immunohistochemical findings in the pancreatic islets of a patient with transfusional iron overload and diabetes: case report
    Miyako Kishimoto
    Department of Diabetes and Metabolic Medicine, National Center for Global Health and Medicine, Tokyo, Japan
    J Med Invest 57:345-9. 2010
    ..Significantly lower levels of immunoreactivity with both insulin antibodies and proinsulin antibodies, but not with glucagon antibodies, was observed in the islet cells in the patient'..
  93. ncbi Plant-based corosolic acid: future anti-diabetic drug?
    Ganapathy Sivakumar
    Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR 72401, USA
    Biotechnol J 4:1704-11. 2009
    ..Corosolic acid may also have some efficacy in the treatment of diabetes, but without induction of anti-insulin antibodies. Recently, corosolic acid from Lagerstroemia speciosa L...
  94. ncbi No risk of diabetes after insulin-shock treatment
    T Bock
    Bartholin Instituttet, Kommunehospitalet, Copenhagen, Denmark
    Lancet 339:1504-6. 1992
    ..blood glucose and plasma insulin concentrations, none had islet-cell antibodies, and only 2 had detectable insulin antibodies. Thus, the risk of diabetes was not increased by the use of many insulin injections in these non-diabetic ..
  95. ncbi Pancreatic islet fibrosis in rock hyraxes (Procavia capensis), Part 1: Case histories, clinical pathology, and epizootiology
    Kathryn C Gamble
    Dallas Zoo and Aquarium at Fair Park, 650 S R L Thornton Freeway, Dallas, Texas 75203, USA
    J Zoo Wildl Med 35:361-9. 2004
    ..Analysis of serum anti-islet and anti-insulin antibodies did not suggest autoimmune disease, and none of the animals had known exposure to toxic substances...
  96. ncbi The double whammy of endogenous insulin antibodies in non-diabetic subjects
    Adel A A Ismail
    Clin Chem Lab Med 46:153-6. 2008
    The presence of high affinity/avidity endogenous insulin antibodies in significant amounts in non-diabetic individuals could uniquely be a double whammy...
  97. ncbi Insulin lispro reduces insulin antibodies in a patient with type 2 diabetes with immunological insulin resistance
    Mahito Asai
    The Second Department of Internal Medicine, Asahikawa Medical College, 078 8510 Hokkaido, Japan
    Diabetes Res Clin Pract 61:89-92. 2003
    ..8%. The patient was subsequently withdrawn from insulin and discharged on diet therapy only. This case demonstrates that insulin lispro may ameliorate resistance to insulin therapy even in the presence of human insulin antibodies.
  98. ncbi Efficacy and safety of inhaled human insulin (Exubera) compared to subcutaneous insulin in children ages 6 to 11 years with type 1 diabetes mellitus: results of a 3-month, randomized, parallel trial
    Neil H White
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Pediatr Endocrinol Metab 21:555-68. 2008
    ..To compare the efficacy and safety of Exubera (EXU) with subcutaneous (SC) insulin in children, ages 6-11 years, with type 1 diabetes mellitus...
  99. ncbi Exploring the idiotypes of insulin antibodies as markers for remission in Type 1 diabetes
    D Devendra
    Department of Endocrinology and Metabolism, Peninsula Medical School, Plymouth Campus, Plymouth, UK
    Diabet Med 21:1316-24. 2004
    ..We created idiotype-specific reagents to explore the idiotypes of insulin antibodies (IA) in a patient in remission, and to compare with a patient who was not.
  100. ncbi The interference of insulin antibodies in insulin immunometric assays
    Remy Sapin
    Unite d Analyses Endocriniennes, CNRS UMR 7004, Universite Louis Pasteur, Faculte de Medecine, Strasbourg, France
    Clin Chem Lab Med 40:705-8. 2002
    We investigated the interference of insulin antibodies in two insulin immunometric assays (Bio-Rad and Elecsys) by measuring direct and free insulin in plasma from 30 patients without insulin antibodies (group 1), as screened by a ..
  101. ncbi Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid
    Yuichiro Takeuchi
    Department of Geriatrics, Shinshu University, Matsumoto, Japan
    Intern Med 46:237-9. 2007
    ..A high insulin level and high titers of insulin antibodies were detected. His HLA genotype contains DRB1* 0406...

Research Grants17

  1. Preservation of Beta Cells by Glutamate Decarboxylase
    Diane Wherrett; Fiscal Year: 2007
    ..for antibodies to insulin, IA-2, and GAD (and ICA in those with 1 positive antibody), if 2 of GAD, IA-2 or insulin antibodies are greater than the 97th percentile, then; staging with intravenous glucose tolerance test (IVGTT) to ..
  2. ENDOGENOUS AND EXOGENOUS INSULIN IN DIABETES MELLITUS
    David Horwitz; Fiscal Year: 1980
    ..By studying the free insulin levels needed to obtain normal glucose values, we can evaluate the roles of exogenous insulin and insulin antibodies in affecting glucose tolerance in the diabetic patient.
  3. GENETIC ORIGIN AND STRUCTURE OF INSULIN ANTIBODIES
    James Thomas; Fiscal Year: 2001
    ..Spontaneous insulin antibodies may accompany systemic autoimmune disorders and are recognized as part of the autoimmune prodrome of type I ..
  4. HLA IN FAMILIES WITH IDD AND NIDD--DISTINCT SUBSET
    Miriam Segall; Fiscal Year: 1992
    ..sex, age at onset, weight history, and treatment history; acute-phase insulin response; and islet-cell and insulin antibodies. These combined studies will help to determine whether there is a "Type X" form of diabetes which can ..
  5. International Congress of the Immunology of Diabetes Soc
    George Eisenbarth; Fiscal Year: 2002
    ..Travel grants for young investigators will be chosen by numerical rating of submitted abstracts and additional travel funding will be applied to plenary lectures chosen by the international organizing committee. ..
  6. Antibodies to Recombinant Autoantigens: Prediction
    George Eisenbarth; Fiscal Year: 2004
    ....
  7. OVARIAN HORMONAL CONTROL OF MEAL SIZE
    NORCROSS GEARY; Fiscal Year: 2008
    ..8) Determine the tonic and phasic effects of estradiol on glutamate synaptogenesis in the brainstem by using immunocytochemical detection of synaptic proteins. [unreadable] [unreadable]..
  8. GENE ENVIRONMENT STUDY OF TYPE 2 DIABETES IN FAMILIES
    Jill Norris; Fiscal Year: 2002
    ....
  9. Chromium and Insulin Action
    William Cefalu; Fiscal Year: 2006
    ..abstract_text> ..
  10. Analgesic tolerance to mu-delta opioid bivalent ligands
    NATALIE LENARD; Fiscal Year: 2006
    ..3) To determine whether tolerance and physical dependence develop during chronic administration of the opioid receptor bivalent ligands. ..
  11. HORMONE REPLACEMENT FOR PREVENTION OF VISCERAL OBESITY
    William Cefalu; Fiscal Year: 2002
    ....
  12. Chromium, Cellular Energy Status and Whole Body Energy Balance
    William Cefalu; Fiscal Year: 2007
    ..abstract_text> ..
  13. Fellowship Training in Pediatric Diabetes at WUMS
    Neil White; Fiscal Year: 2007
    ..The success of this program will be realized as its participants enter the ranks of leadership as physician-scientists in pediatric diabetes over the next decades [unreadable] [unreadable]..
  14. Career Development in Pediatric Diabetes at WUMS
    Neil White; Fiscal Year: 2005
    ..The success of this program will be realized as its participants enter the ranks of leadership as physician-scientists in pediatric diabetes over the next decades. ..
  15. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Jill Norris; Fiscal Year: 2009
    ....
  16. CALORIC RESTRICTION, AGING, AND INSULIN ACTION
    William Cefalu; Fiscal Year: 2001
    ....
  17. CONTROL OF ALCOHOL INTAKE BY BRAIN-GUT PEPTIDES
    NORCROSS GEARY; Fiscal Year: 2003
    ..The work will be closely coordinated, and we expect this cooperative effort to be very productive. ..