immunoglobulin g

Summary

Summary: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Top Publications

  1. ncbi Fcgamma receptors as regulators of immune responses
    Falk Nimmerjahn
    Laboratory of Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054 Erlangen, Germany
    Nat Rev Immunol 8:34-47. 2008
  2. ncbi Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    Elizabeth A Leadbetter
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nature 416:603-7. 2002
  3. ncbi A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
    Vanda A Lennon
    Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Lancet 364:2106-12. 2004
  4. pmc IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
    Vanda A Lennon
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Exp Med 202:473-7. 2005
  5. ncbi Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity
    Robert L Shields
    Department of Immunology, Genentech, Inc, 1 South San Francisco, CA 94080, USA
    J Biol Chem 277:26733-40. 2002
  6. pmc Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain
    Samira Saadoun
    Academic Neurosurgery Unit, St George s, University of London, London, UK
    Ann Neurol 71:323-33. 2012
  7. ncbi Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses
    Pierre Bruhns
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Blood 113:3716-25. 2009
  8. ncbi Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders
    Y Masaki
    Department of Hematology and Immunology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Kahoku gun, Ishikawa, 920 0293, Japan
    Ann Rheum Dis 68:1310-5. 2009
  9. pmc Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
    C J Drakeley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 102:5108-13. 2005
  10. ncbi High serum IgG4 concentrations in patients with sclerosing pancreatitis
    H Hamano
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    N Engl J Med 344:732-8. 2001

Detail Information

Publications379 found, 100 shown here

  1. ncbi Fcgamma receptors as regulators of immune responses
    Falk Nimmerjahn
    Laboratory of Experimental Immunology and Immunotherapy, Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054 Erlangen, Germany
    Nat Rev Immunol 8:34-47. 2008
    ....
  2. ncbi Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    Elizabeth A Leadbetter
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nature 416:603-7. 2002
    ..The unique features of this dual-engagement pathway should facilitate the development of therapies that specifically target autoreactive B cells...
  3. ncbi A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis
    Vanda A Lennon
    Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
    Lancet 364:2106-12. 2004
    ..We assessed the capacity of a putative marker for neuromyelitis optica (NMO-IgG) to distinguish neuromyelitis optica and related disorders from multiple sclerosis...
  4. pmc IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
    Vanda A Lennon
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Exp Med 202:473-7. 2005
    ..A serum immunoglobulin G autoantibody (NMO-IgG) serves as a specific marker for NMO...
  5. ncbi Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity
    Robert L Shields
    Department of Immunology, Genentech, Inc, 1 South San Francisco, CA 94080, USA
    J Biol Chem 277:26733-40. 2002
    ..When combined with an IgG1 Fc protein variant that exhibited enhanced antibody-dependent cellular cytotoxicity, the lack of fucose was synergistic...
  6. pmc Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain
    Samira Saadoun
    Academic Neurosurgery Unit, St George s, University of London, London, UK
    Ann Neurol 71:323-33. 2012
    ..The presence of neutrophils is a characteristic feature in NMO lesions in humans. Neutrophils are not generally found in multiple sclerosis lesions. We evaluated the role of neutrophils in a mouse NMO model...
  7. ncbi Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses
    Pierre Bruhns
    Institut Pasteur, Departement d Immunologie, Unité d Allergologie Moléculaire et Cellulaire, Paris, France
    Blood 113:3716-25. 2009
    ..They therefore highlight the role of specific hFcgammaRs in the therapeutic and pathogenic effects of antibodies in disease...
  8. ncbi Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders
    Y Masaki
    Department of Hematology and Immunology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Kahoku gun, Ishikawa, 920 0293, Japan
    Ann Rheum Dis 68:1310-5. 2009
    ..Mikulicz's disease (MD) has been considered as one manifestation of Sjögren's syndrome (SS). Recently, it has also been considered as an IgG(4)-related disorder...
  9. pmc Estimating medium- and long-term trends in malaria transmission by using serological markers of malaria exposure
    C J Drakeley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 102:5108-13. 2005
    ..Thus, serological tools allow us to detect variations in malaria transmission over time. Such tools will be invaluable for monitoring trends in malaria endemicity and the effectiveness of malaria control programs...
  10. ncbi High serum IgG4 concentrations in patients with sclerosing pancreatitis
    H Hamano
    Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    N Engl J Med 344:732-8. 2001
    ..CONCLUSIONS: Patients with sclerosing pancreatitis have high serum IgG4 concentrations, providing a useful means of distinguishing this disorder from other diseases of the pancreas or biliary tract...
  11. ncbi Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
    Solbritt Rantapaa-Dahlqvist
    Umea Universitet, Umea, Sweden
    Arthritis Rheum 48:2741-9. 2003
    ....
  12. ncbi Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis
    Shanu F Roemer
    Department of Neurology, Mayo Clinic, College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Brain 130:1194-205. 2007
    ..These findings strongly support a role for a complement activating AQP4-specific autoantibody as the initiator of the NMO lesion, and further distinguish NMO from MS...
  13. ncbi Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation
    Yoshikatsu Kaneko
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 313:670-3. 2006
    b>Immunoglobulin G (IgG) mediates pro- and anti-inflammatory activities through the engagement of its Fc fragment (Fc) with distinct Fcg receptors (FcgRs)...
  14. ncbi Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo
    Monika Bradl
    Department of Neuroimmunology, Medical University Vienna, Center for Brain Research, Vienna, Austria
    Ann Neurol 66:630-43. 2009
    ..A diagnostic hallmark of this disease is the presence of serum autoantibodies against the water channel aquaporin-4 (AQP-4) on astrocytes...
  15. ncbi FcRn: the neonatal Fc receptor comes of age
    Derry C Roopenian
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:715-25. 2007
    ..This Review summarizes these two areas of FcRn biology...
  16. pmc Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose
    Claudia Ferrara
    Pharma Research and Early Development, Roche Glycart AG, CH 8952 Schlieren, Switzerland
    Proc Natl Acad Sci U S A 108:12669-74. 2011
    ..These findings allow us to understand the higher efficacy of therapeutic antibodies lacking the core fucose and also suggest a unique mechanism by which the immune system can regulate antibody-mediated effector functions...
  17. pmc Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro
    P W Parren
    Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 75:8340-7. 2001
    ..The significance of such substerilizing neutralizing antibody titers in the context of a potent cellular immune response is an important area for further study...
  18. pmc Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice
    Samira Saadoun
    St George s, University of London, London SW17 0RE, UK
    Brain 133:349-61. 2010
    ..Here, we investigated whether immunoglobulin G from aquaporin-4-autoantibody-positive neuromyelitis optica patients has the potential to damage the central ..
  19. pmc Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
    Thomas Tiller
    Max Planck Institute for Infection Biology, D 10117 Berlin, Germany
    J Immunol Methods 329:112-24. 2008
    ....
  20. ncbi A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  21. ncbi Protection against lethal enterovirus 71 infection in newborn mice by passive immunization with subunit VP1 vaccines and inactivated virus
    C N Wu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Vaccine 20:895-904. 2001
    ..Our data indicated that inactivated virus is the choice of vaccine preparation capable of fulfilling the demand for effective control, and that VP1 subunit vaccines remain promising vaccine strategies that require further refinement...
  22. pmc A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection
    Wataru Akahata
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Med 16:334-8. 2010
    ..Immunization with alphavirus VLP vaccines represents a strategy to contain the spread of CHIKV and related pathogenic viruses in humans...
  23. pmc Hepatitis E virus antibodies in blood donors, France
    Jean Michel Mansuy
    Hopital Purpan, Toulouse, France
    Emerg Infect Dis 17:2309-12. 2011
    ..5% of voluntary blood donors in southwestern France. This finding suggests HEV is highly endemic to this region. The high HEV prevalence may reflect local dietary practices, such as eating uncooked pork and game products...
  24. ncbi The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity
    Toyohide Shinkawa
    Tokyo Research Laboratories, Kyowa Hakko Kogyo Co, Ltd, 3 6 6 Asahi machi, Machida shi, Tokyo 194 8533, Japan
    J Biol Chem 278:3466-73. 2003
    ....
  25. pmc Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies
    Nicole A Doria-Rose
    LIR, NIAID, National Institutes of Health, Bldg 10, Rm 7N246, 10 Center Dr, Bethesda, MD 20892, USA
    J Virol 83:188-99. 2009
    ..We found that 0.0031% of B cells and 0.047% of plasmablasts secreted Env-specific immunoglobulin G (IgG) in an enzyme-linked immunospot (ELISPOT) assay...
  26. pmc Dried blood spots as a source of anti-malarial antibodies for epidemiological studies
    Patrick H Corran
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Malar J 7:195. 2008
    ..Although recommendations for the storage and analysis of small molecule analytes in blood spots exist, there are no published systematic studies of the stability of antibodies under different storage conditions...
  27. pmc Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness
    Danielle I Stanisic
    Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Infect Immun 77:1165-74. 2009
    ..Different malaria antigens induce distinct immunoglobulin G (IgG) subclass responses, but the importance of different responses in protective immunity from malaria is ..
  28. ncbi Rituximab therapy leads to rapid decline of serum IgG4 levels and prompt clinical improvement in IgG4-related systemic disease
    Arezou Khosroshahi
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Rheum 62:1755-62. 2010
    ..This study was performed to assess the clinical and serologic responses to B lymphocyte depletion therapy with rituximab in patients with IgG4-RSD...
  29. ncbi Strategies and challenges for the next generation of therapeutic antibodies
    Alain Beck
    Centre d Immunologie Pierre Fabre CIPF, 5 Avenue Napoleon III, F74160, Saint Julien en Genevois, France
    Nat Rev Immunol 10:345-52. 2010
    ..Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions...
  30. ncbi Diagnosis of autoimmune pancreatitis: the Mayo Clinic experience
    Suresh T Chari
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Clin Gastroenterol Hepatol 4:1010-6; quiz 934. 2006
    ..AIP has unique histologic features associated with infiltration of tissues of affected organs with abundant IgG4-positive cells. We propose expanded diagnostic criteria for AIP with a cohort of histologically confirmed AIP...
  31. pmc A new conceptualization for Mikulicz's disease as an IgG4-related plasmacytic disease
    Motohisa Yamamoto
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1, West 16, Chuo Ku, Sapporo 060 8543, Japan
    Mod Rheumatol 16:335-40. 2006
    ..Mikulicz's disease thus differs from SS and may be a systemic IgG4-related plasmacytic disease...
  32. ncbi Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis
    T Misu
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1224-34. 2007
    ....
  33. ncbi Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange
    Marijn van der Neut Kolfschoten
    Sanquin Research AMC Landsteiner Laboratory, Department of Immunopathology, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Science 317:1554-7. 2007
    ..We describe a novel posttranslational modification that leads to anti-inflammatory activity of antibodies of immunoglobulin G, isotype 4 (IgG4)...
  34. ncbi Immunoglobulin G4: an odd antibody
    R C Aalberse
    Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Allergy 39:469-77. 2009
    ..The existence of the IgG4 subclass, its up-regulation by anti-inflammatory factors and its own anti-inflammatory characteristics may help the immune system to dampen inappropriate inflammatory reactions...
  35. ncbi DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    Mikhail B Litinskiy
    Division of Molecular Immunology, Department of Pathology and Laboratory Medicine, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:822-9. 2002
    ..By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses...
  36. ncbi Revised diagnostic criteria for neuromyelitis optica
    D M Wingerchuk
    Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    Neurology 66:1485-9. 2006
    ..A serum autoantibody marker, NMO-IgG, is highly specific for NMO. The authors propose revised NMO diagnostic criteria that incorporate NMO-IgG status...
  37. ncbi A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries
    Richard Bendall
    Clinical Microbiology, Royal Cornwall Hospital Trust, Truro, United Kingdom
    J Med Virol 82:799-805. 2010
    ....
  38. pmc Performance characteristics of the immunoglobulin G-capture BED-enzyme immunoassay, an assay to detect recent human immunodeficiency virus type 1 seroconversion
    Trudy Dobbs
    HIV Immunology and Diagnostics Branch, Mailstop D12, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    J Clin Microbiol 42:2623-8. 2004
    Recently, we developed an immunoglobulin G (IgG)-capture BED-enzyme immunoassay (BED-CEIA) to identify recent human immunodeficiency virus (HIV) type 1 (HIV-1) seroconversion for use in incidence estimates...
  39. ncbi Analysis of immunoglobulin glycosylation by LC-ESI-MS of glycopeptides and oligosaccharides
    Johannes Stadlmann
    Department of Chemistry, University of Natural Resources and Applied Life Sciences BOKU, Vienna, Austria
    Proteomics 8:2858-71. 2008
    ..Regarding fast and yet detailed structural assignment, LC-MS on graphitic carbon supersedes all other current methods...
  40. pmc Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc
    Robert M Anthony
    Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, NY 10021, USA
    Science 320:373-6. 2008
    It is well established that high doses of monomeric immunoglobulin G (IgG) purified from pooled human plasma [intravenous immunoglobulin (IVIG)] confer anti-inflammatory activity in a variety of autoimmune settings...
  41. ncbi Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design
    E O Saphire
    Department of Molecular Biology, Department of Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 293:1155-9. 2001
    ..The structure, together with mutagenesis studies, provides a rationale for the extensive cross-reactivity of b12 and a valuable framework for the design of HIV-1 vaccines capable of eliciting b12-like activity...
  42. ncbi Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccines
    Simon J Draper
    Jenner Institute, University of Oxford, Oxford, OX3 7DQ, United Kingdom
    J Immunol 185:7583-95. 2010
    ..These data encourage the further clinical development and coadministration of protein and viral vector vaccine platforms in an attempt to induce broad cellular and humoral immune responses against blood-stage malaria Ags in humans...
  43. pmc Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
    Jens Wrammert
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 453:667-71. 2008
    ..However, we found that most of the influenza-virus-specific mAbs showed the highest affinity for the current vaccine strain. Thus, OAS does not seem to be a common occurrence in normal, healthy adults receiving influenza vaccination...
  44. pmc Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses
    Lisa C Zaba
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 204:3183-94. 2007
    ..Th17 cells may be particularly important in driving epidermal activation in psoriatic plaques, whereas Th1 cells must also be eliminated for final disease resolution...
  45. ncbi Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity
    Andrea Jegerlehner
    Cytos Biotechnology, Schlieren, Switzerland
    J Immunol 172:5598-605. 2004
    ....
  46. ncbi The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex
    P Sondermann
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Nature 406:267-73. 2000
    ..Thus the described structure is a model for immune complex recognition and helps to explain the vastly differing affinities of other Fc gammaR-IgG complexes and the Fc epsilonRI alpha-IgE complex...
  47. ncbi Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo
    Aran F Labrijn
    Genmab, Utrecht, The Netherlands
    Nat Biotechnol 27:767-71. 2009
    ....
  48. ncbi Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia
    Jack S Richards
    Department of Medical Biology, Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Victoria, Australia
    Clin Infect Dis 51:e50-60. 2010
    ..Erythrocyte-binding antigens (EBAs) are important erythrocyte invasion ligands used by merozoites and may be targets of protective immunity, but there are limited data examining their potential importance...
  49. ncbi International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology
    Tooru Shimosegawa
    Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Pancreas 40:352-8. 2011
    ..To achieve the goal of developing international consensus diagnostic criteria (ICDC) for autoimmune pancreatitis (AIP)...
  50. ncbi A new clinicopathological entity of IgG4-related autoimmune disease
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, 113 8677, Tokyo, Japan
    J Gastroenterol 38:982-4. 2003
    ..Autoimmune pancreatitis (AIP) is occasionally associated with other autoimmune diseases...
  51. pmc Human antibody responses to the Anopheles salivary gSG6-P1 peptide: a novel tool for evaluating the efficacy of ITNs in malaria vector control
    Papa Makhtar Drame
    UR016 Contrôle et Caractérisation des Populations de Vecteurs, Institut de Recherche pour le Developpement, Cotonou, Benin
    PLoS ONE 5:e15596. 2010
    ....
  52. ncbi Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner's tumor)
    Satoshi Kitagawa
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Am J Surg Pathol 29:783-91. 2005
    ..The abundance of IgG4-positive plasma cells in the lesions would be useful for distinguishing CSS from other forms of sialadenitis...
  53. ncbi Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
    M Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, 1 Aspenlea Road, London W6 8LH, United Kingdom
    Annu Rev Immunol 19:163-96. 2001
    ..Infliximab (a mAB), and etanercept (a sTNF-R-Fc fusion protein) have been approved by regulatory authorities in the United States and Europe for treating RA, and they represent a significant new addition to available therapeutic options...
  54. ncbi NMO-IgG predicts the outcome of recurrent optic neuritis
    M Matiello
    Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Neurology 70:2197-200. 2008
    To determine the prognostic value of neuromyelitis optica (NMO)-immunoglobulin G (IgG) in patients with recurrent optic neuritis (ON)...
  55. pmc Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM
    M Boes
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 97:1184-9. 2000
    ..These findings suggest that secreted IgM, including IgM autoantibodies produced naturally or as part of an autoimmune response, may lessen the severity of autoimmune pathology associated with IgG autoantibodies...
  56. ncbi Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre
    Toshiyuki Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1235-43. 2007
    ....
  57. ncbi The role of IL-10 in promoting disease progression in leishmaniasis
    M M Kane
    Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Immunol 166:1141-7. 2001
    ..This IgG allows amastigotes to exploit the antiinflammatory effects of Fc gamma R ligation to induce the production of IL-10, which renders macrophages refractory to the activating effects of IFN-gamma...
  58. ncbi Evaluation of the antibody response to Anopheles salivary antigens as a potential marker of risk of malaria
    Franck Remoue
    Institut de recherche pour le developpement IRD, UR24 Epidémiologie et Prévention Unit, Centre IRD de Hann, BP 1386, Dakar, Senegal
    Trans R Soc Trop Med Hyg 100:363-70. 2006
    ..These results suggest that evaluation of antisalivary Ab responses could be a useful approach for identifying a marker for the risk of malaria transmission...
  59. ncbi Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure
    Richard Strasser
    Institute of Applied Genetics and Cell Biology, University of Natural Resources and Applied Life Sciences, Muthgasse 18, 1190 Vienna, Austria
    Plant Biotechnol J 6:392-402. 2008
    ..The generated RNAi lines were stable, viable and did not show any obvious phenotype, thus providing a robust tool for the production of therapeutically relevant glycoproteins in plants with a humanized N-glycan structure...
  60. pmc IgG responses to Anopheles gambiae salivary antigen gSG6 detect variation in exposure to malaria vectors and disease risk
    Will Stone
    Department of Immunity and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom
    PLoS ONE 7:e40170. 2012
    ..While the technique requires further evaluation in a range of malaria endemic settings, our findings suggest that the gSG6 assay may have a role in the evaluation and planning of targeted and preventative anti-malaria interventions...
  61. ncbi Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength
    Aran F Labrijn
    Genmab, 3584 CM Utrecht, The Netherlands
    J Immunol 187:3238-46. 2011
    ..The current insights impact our view of humoral immunity and should furthermore be considered in the design and evaluation of Ab-based studies and therapeutics...
  62. ncbi Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity
    S B Boppana
    Department of Pediatrics, University of Alabama at Birmingham, 35233, USA
    N Engl J Med 344:1366-71. 2001
    ..Whether congenital CMV infection in the offspring of women who are seropositive for CMV can occur after maternal reinfection with a different strain of CMV is unknown...
  63. ncbi Cytomegalovirus seroprevalence in the United States: the national health and nutrition examination surveys, 1988-2004
    Sheri Lewis Bate
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 50:1439-47. 2010
    ..from the National Health and Nutrition Examination Survey (NHANES) 1999-2004 were tested for CMV-specific immunoglobulin G antibody, and results were compared with those from NHANES III (1988-1994)...
  64. pmc Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway
    Robert M Anthony
    Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 475:110-3. 2011
    High-dose intravenous immunoglobulin is a widely used therapeutic preparation of highly purified immunoglobulin G (IgG) antibodies...
  65. ncbi Quantitative analysis of the interaction strength and dynamics of human IgG4 half molecules by native mass spectrometry
    Rebecca J Rose
    Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
    Structure 19:1274-82. 2011
    ..Hence, native MS has provided a quantitative view of local structural features that define biological properties of IgG4...
  66. pmc Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways
    Magdalena A Berkowska
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Blood 118:2150-8. 2011
    ..Our findings shed light on human germinal center-dependent and -independent B-cell memory formation and provide new opportunities to study these processes in immunologic diseases...
  67. ncbi Targeted anticytokine therapy in patients with chronic heart failure: results of the Randomized Etanercept Worldwide Evaluation (RENEWAL)
    Douglas L Mann
    Winters Center for Heart Failure Research, Baylor College of Medicine and the Houston VA, Houston, Tex 77030, USA
    Circulation 109:1594-602. 2004
    ..Studies in experimental models and preliminary clinical experience suggested a possible therapeutic role for the soluble tumor necrosis factor antagonist etanercept in heart failure...
  68. pmc Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers
    Gordan Lauc
    Glycobiology Laboratory, Genos, Zagreb, Croatia
    PLoS Genet 9:e1003225. 2013
    Glycosylation of immunoglobulin G (IgG) influences IgG effector function by modulating binding to Fc receptors. To identify genetic loci associated with IgG glycosylation, we quantitated N-linked IgG glycans using two approaches...
  69. pmc A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details
    Hisanori Umehara
    Division of Hematology and Immunology, Department of Internal Medicine, Kanazawa Medical University, 1 1 Daigaku, Uchinada machi, Kahoku gun 920 0293, Ishikawa, Japan
    Mod Rheumatol 22:1-14. 2012
    ..Here we describe the concept of IgG4RD and up-to-date information on this emerging disease entity...
  70. pmc Enhanced HIV-1 neutralization by antibody heteroligation
    Hugo Mouquet
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:875-80. 2012
    ..Heterotypic bivalent binding enhanced neutralization compared with the parental antibodies. We conclude that antibody recognition and viral neutralization of HIV can be improved by heteroligation...
  71. pmc Relationship between exposure to vector bites and antibody responses to mosquito salivary gland extracts
    Albin Fontaine
    Unite de Parasitologie, Antenne Marseille de l Institut de Recherche Biomédicale des Armées, Marseille, France
    PLoS ONE 6:e29107. 2011
    ..caspius density. Characterisation of such immunological-markers may allow the evaluation of the effectiveness of vector-control strategies or estimation of the risk of vector-borne disease transmission...
  72. ncbi Recent advances in the concept and diagnosis of autoimmune pancreatitis and IgG4-related disease
    Kazuichi Okazaki
    Division of Gastroenterology and Hepatology, The Third Department of Internal Medicine, Kansai Medical University, Shinmachi, Hirakata, Osaka 573 1197, Japan
    J Gastroenterol 46:277-88. 2011
    ..The concept and diagnostic criteria of "IgG4-related disease" will be changed in accordance with future studies...
  73. ncbi IgG4-related systemic disease and lymphoplasmacytic aortitis
    John H Stone
    rhumatology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Arthritis Rheum 60:3139-45. 2009
    ..Treatment of the aortitis may prevent progression of the IgG4-related systemic disease to involvement of other organs. IgG4-related systemic disease should be considered in all patients with aortitis judged to be of unknown etiology...
  74. pmc Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells
    Kristi Baker
    Division of Gastroenterology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:9927-32. 2011
    ..Given the centrality of FcRn in controlling cross-presentation, these studies lay the foundation for a unique means to therapeutically manipulate CD8(+) T-cell responses...
  75. ncbi IgG4-related disease: a cross-sectional study of 114 cases
    Yoh Zen
    Institute of Liver Studies, King s College Hospital, London, UK
    Am J Surg Pathol 34:1812-9. 2010
    ..Further study is necessary to conclude whether these features reflect different manifestations of a single disease entity or suggest different underlying etiologic factors...
  76. ncbi Pathological classification of hepatic inflammatory pseudotumor with respect to IgG4-related disease
    Yoh Zen
    Department of Human Pathology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Mod Pathol 20:884-94. 2007
    ....
  77. pmc Use of an immunoglobulin G avidity test to discriminate between primary and secondary dengue virus infections
    Vanda Akico Ueda Fick de Souza
    Laboratório de Virologia LIMHC 52, Instituto de Medicina Tropical de Sao Paulo, Brazil
    J Clin Microbiol 42:1782-4. 2004
    An enzyme-linked immunosorbent assay-based immunoglobulin G (IgG) antibody avidity test was evaluated by using sera from 57 patients with acute dengue infection...
  78. ncbi Complement activation by (auto-) antibodies
    Nina A Daha
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Mol Immunol 48:1656-65. 2011
    ..In the current review, we discuss complement activation by (auto-) antibodies by the different pathways...
  79. ncbi Therapeutic evaluation of etanercept in a model of traumatic brain injury
    Chung Ching Chio
    Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan
    J Neurochem 115:921-9. 2010
    ..These findings suggest that etanercept may improve outcomes of TBI by penetrating into the cerebrospinal fluid in rats...
  80. ncbi Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries
    Thomas Jostock
    Dyax s a, Sart Tilman, Liege, Belgium
    J Immunol Methods 289:65-80. 2004
    ..Our technology allows the generation and production of antigen-specific complete human antibodies as fast or even faster than raising monoclonal antibodies by conventional hybridoma techniques...
  81. ncbi Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission
    Orin Courtenay
    Ecology and Epidemiology Group, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom
    J Infect Dis 186:1314-20. 2002
    ..There were positive correlations between infectiousness and anti-Leishmania immunoglobulin G, parasite detection by polymerase chain reaction, and clinical disease (logistic regression, r2=0.08-0.18)...
  82. pmc Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity
    Hitoshi Suzuki
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 119:1668-77. 2009
    ..Collectively, these findings indicate that glycan-specific antibodies are associated with the development of IgAN and may represent a disease-specific marker and potential therapeutic target...
  83. pmc Comparison of two commercially available dengue virus (DENV) NS1 capture enzyme-linked immunosorbent assays using a single clinical sample for diagnosis of acute DENV infection
    Kovi Bessoff
    Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, Dengue Branch, SanJuan, Puerto Rico 00920
    Clin Vaccine Immunol 15:1513-8. 2008
    ..The immunoglobulin G titer was found to be the only covariate that significantly influenced results in the Bio-Rad test, while ..
  84. ncbi Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity
    S Krapp
    Max Planck Institut fur Biochemie, Abteilung Strukturforschung, Am Klopferspitz 18a, D 82152, Martinsried, Germany
    J Mol Biol 325:979-89. 2003
    ..These data provide a structural rationale for the previously observed modulation of effector activities reported for this series of proteins...
  85. pmc Autoimmune pancreatitis: proposal of IgG4-related sclerosing disease
    Terumi Kamisawa
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3 18 22 Honkomagome, Bunkyo ku, Tokyo, 113 8677, Japan
    J Gastroenterol 41:613-25. 2006
    ..We propose a new clinicopathological entity, "IgG4-related sclerosing disease", and suggest that AIP is a pancreatic lesion reflecting this systemic disease...
  86. pmc A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin
    Lori M Neal
    Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York 12208, USA
    Infect Immun 78:552-61. 2010
    ..The potential of GD12 to serve as a therapeutic following ricin challenge was not explored in this study...
  87. ncbi First attempt to validate the gSG6-P1 salivary peptide as an immuno-epidemiological tool for evaluating human exposure to Anopheles funestus bites
    Anne Poinsignon
    Unité Caractérisation et Contrôle des Populations de Vecteurs, Institut de Recherche pour le Developpement, Montpellier, France
    Trop Med Int Health 15:1198-203. 2010
    ..gambiae exposure. This study represents a first attempt to validate the gSG6-P1 peptide as an epidemiological tool evaluating exposure to An. funestus bites, the second main malaria vector in sub-Saharan Africa...
  88. ncbi Determination of mean recency period for estimation of HIV type 1 Incidence with the BED-capture EIA in persons infected with diverse subtypes
    Bharat S Parekh
    Division of Global AIDS Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 27:265-73. 2011
    ..The determination of ω with more data and new methodology suggests that ω of the BED-CEIA varies between different subtypes and/or populations. These estimates for ω may affect incidence estimates in various studies...
  89. ncbi Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis
    Yoh Zen
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13 1 Takarama chi, Kanazawa 920 8640, Japan
    Hepatology 45:1538-46. 2007
    ..CONCLUSION: AIPC is a unique inflammatory disorder characterized by an immune reaction predominantly mediated by Th2 cells and Tregs...
  90. ncbi Clinical and pathological characteristics of Mikulicz's disease (IgG4-related plasmacytic exocrinopathy)
    Motohisa Yamamoto
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine, South 1 West 16, Chuo Ku, Sapporo, Hokkaido 0608543, Japan
    Autoimmun Rev 4:195-200. 2005
    ..We here propose the new entity "IgG4-related plasmacytic exocrinopathy" and expect future development with regard to its relationship with autoimmune pancreatitis, which similarly presents elevated serum IgG4 levels...
  91. pmc Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal
    Kazuichi Okazaki
    The Third Department of Internal Medicine, Kansai Medical University, Moriguchi, Japan
    J Gastroenterol 41:626-31. 2006
  92. ncbi Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS
    S Wang
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    Blood 96:2808-13. 2000
    ..The results indicate that B7-H2 is a putative ligand for the ICOS T-cell molecule. (Blood. 2000;96:2808-2813)..
  93. ncbi IgG4-related diseases including Mikulicz's disease and sclerosing pancreatitis: diagnostic insights
    Yasufumi Masaki
    Department of Hematology and Immunology, Kanazawa Medical University, Kahoku gun, Ishikawa, Japan
    J Rheumatol 37:1380-5. 2010
    ..The Japanese IgG4 research group has begun multicenter prospective studies to improve diagnostic criteria and treatment strategies...
  94. ncbi Rat and human myelin oligodendrocyte glycoproteins induce experimental autoimmune encephalomyelitis by different mechanisms in C57BL/6 mice
    Alfred R Oliver
    Department of Epidemiology and Public Health and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 171:462-8. 2003
    ....
  95. ncbi Immunoglobulin G4-associated cholangitis: clinical profile and response to therapy
    Amaar Ghazale
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Gastroenterology 134:706-15. 2008
    ..We describe clinical features, treatment response, and predictors of relapse in IAC and compare relapse rates in IAC with intrapancreatic vs proximal bile duct strictures...
  96. pmc Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica
    Jeffrey L Bennett
    Department of Neurology and Ophthalmology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Ann Neurol 66:617-29. 2009
    ..Our objectives were to determine the source of central nervous system (CNS) NMO-IgGs and their role in disease pathogenesis...
  97. ncbi Possible involvement of T helper type 2 responses to Toll-like receptor ligands in IgG4-related sclerosing disease
    Reiko Akitake
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Gut 59:542-5. 2010
    ....
  98. ncbi IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    Marek Jutel
    Swiss Institute of Allergy and Asthma Research SIAF, Davos, Switzerland
    Eur J Immunol 33:1205-14. 2003
    ..Together, these results demonstrate a deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens...
  99. ncbi Placental transport of immunoglobulin G
    Neil E Simister
    Rosenstiel Center for Basic Biomedical Sciences and Biology Department, Brandeis University, 415 South Street, Waltham, MA 02254 9110, USA
    Vaccine 21:3365-9. 2003
    Maternal antibodies transported across the placenta protect the newborn. Maternal immunoglobulin G (IgG) concentrations in fetal blood increase from early in the second trimester through term, most antibodies being acquired during the ..
  100. pmc Clonal dissection of the human memory B-cell repertoire following infection and vaccination
    Debora Pinna
    Institute for Research in Biomedicine, Bellinzona, Switzerland
    Eur J Immunol 39:1260-70. 2009
    ..These results reveal novel aspects of memory B-cell kinetics and provide a powerful tool to monitor immune responses following infection and vaccination...
  101. pmc Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm
    Melissa D Simek
    International AIDS Vaccine Initiative, New York, NY 10028, USA
    J Virol 83:7337-48. 2009
    ..These elite neutralizers provide promising starting material for the isolation of broadly neutralizing monoclonal antibodies to assist in HIV-1 vaccine design...

Research Grants71

  1. Anti-TfR IgG3-Av: A New Drug Against Multiple Myeloma
    MANUEL PENICHET; Fiscal Year: 2009
    ..We would like to stress that the impact of the results obtained from the present studies is not restricted to MM. Similar approaches can be applied to other hematopoietic malignancies such as leukemias and lymphomas. ..
  2. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..There is evidence that HIV-1 impairs protective immunoglobulin G (IgG) and immunoglobulin A (IgA) responses against pathogens and vaccines by inducing progressive loss of ..
  3. Impacts of surface receptors [Toll like receptor (TLRs) and Fc gamma receptors (F
    Collins Ouma; Fiscal Year: 2012
    ..This information will be important since the primary goal of our genetic-based investigations is to identify susceptible groups for targeted therapeutic interventions. ..
  4. Epigenetic downregulation of the antibody response and inhibition of autoimmunity
    Paolo Casali; Fiscal Year: 2013
    ....
  5. Chemokine Decoy Receptor for Therapy of Autoimmune Arthritis
    Kanneganti Murthy; Fiscal Year: 2012
    ..We will test this agent in a clinically-relevant small animal model and determine the most effective dose, in anticipation of definitive large animal studies to confirm its efficacy and safety. ..
  6. SCHISTOSOME EGG INDUCED TH2 RESPONSES
    Edward J Pearce; Fiscal Year: 2013
    ....
  7. Complement Activation on Neisseria meningitidis
    Sanjay Ram; Fiscal Year: 2013
    ..The studies proposed in this application will help us better understand how this pathogen escapes killing by complement and will ultimately aid in the development of better vaccines against meningococcal meningitis. ..
  8. Towards a vaccine against Fasciola hepatica using FhSAP2 as an antigen
    Ana M Espino; Fiscal Year: 2013
    ..We propose to optimize the vaccine formulation and improve the efficacy of the vaccine. In doing so in the future we will be able to evaluate the optimized vaccine in ruminants. ..
  9. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
    ..These diseases affect millions of Americans and have unmet needs for new therapies. ..
  10. Discovery of Critical Host Genes Enabling Resistance to HIV-1 Infection as Therap
    Leyla S Diaz; Fiscal Year: 2012
    ..These antibodies are expected to be active against all variants of HIV, including those with resistance to current antiviral therapies. ..
  11. Antibody cytokine fusion proteins against Cryptococcus neoformans
    DAVID OWEN BEENHOUWER; Fiscal Year: 2012
    ..The proposed studies have relevance beyond cryptococcal infection, since a significant long-term objective is to design antibody-cytokine fusion proteins for use in other types of infections. ..
  12. Functional impact of IL33 polymorphisms on asthma &other Th2-mediated diseases
    Kathleen C Barnes; Fiscal Year: 2013
    ..Results from this study will provide novel insights into the role of IL-33 in the pathogenesis of two diseases of high public health significance. ..
  13. Tc-99m-Labled Cytokine Ligands and SPECT Inflammation Imaging of Ischemic Hearts
    Zhonglin Liu; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Development of highly specific imaging agents for noninvasive detection of inflammation induced by heart attacks. ..
  14. A Novel IgE Cancer Therapeutic Specific for the Epithelial Membrane Protein-2
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..Given the high expression of EMP2 on a number of malignancies, these studies will be important to establish the anti-EMP2 IgE as a potential therapeutic for cancers in women. ..
  15. Immune Tolerance in Non-clonal Immune Systems
    David Nemazee; Fiscal Year: 2013
    ..The goal of this project is to determine how immune tolerance normally suppresses the generation of self reactive antibodies and to identify genes involved in the process. ..
  16. Development of an Anti-PSGL-1 Antibody to Treat Crohn's Disease
    Scott A Rollins; Fiscal Year: 2011
    ..S. The drug being developed addresses a major unmet medical need for a therapy that can maintain remission and/or ameliorate the devastating effects of this disease. ..
  17. Protective immunity against HIV: the role of IgG subclass and glycosylation
    Donald Forthal; Fiscal Year: 2009
    ..Such studies may lead to methods of improving the ability of antibody to inhibit HIV and eventually to the development of effective HIV/AIDS vaccines. ..
  18. Novel Nanopolymers to Inhibit Angiogenesis and Increase the Anti-tumor Immunity
    Manuel L Penichet; Fiscal Year: 2013
    ..A novel nanobiopolymer-based therapy against HER2/neu expressing cancer cells with sufficient capacity to inhibit angiogenesis and orchestrate an anti-tumor immune response should make a significant clinical impact. ..
  19. Novel IL-15 Superagonist Therapy for Bladder Cancer
    Hing C Wong; Fiscal Year: 2011
    ....
  20. IL-15 Superagonist Complex as an Immunotherapeutic for Multiple Myeloma
    Hing C Wong; Fiscal Year: 2012
    ..Positive outcomes from this proposed study would provide justification for clinical development of this complex as a safe, durable, potent and cell-mediated immunotherapy to treat patients with multiple myeloma. ..
  21. An immunoadhesin for treatment of hypercholesterolemia
    KEITH WYCOFF; Fiscal Year: 2012
    ..A receptor decoy based on a protein fragment of the low-density lipoprotein receptor fused to IgG Fc is expected to dramatically lower LDL-C and reduce the risk of coronary artery disease. ..
  22. Estrogen Effects on Vascular Inflammation are Age and Hormone-Status Dependent
    Fadi Hage; Fiscal Year: 2013
    ..system is required for the pro-inflammatory effect of CRP, which is mediated via its interaction with the immunoglobulin G Fc receptors (Fc?Rs) on monocytes/macrophages...
  23. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne A Marasco; Fiscal Year: 2010
    ..A protective genetic microbicide delivered to the female lower genital track could dramatically slow the spread of HIV/AIDS. ..
  24. The Role of Intrathecal Plasma Cell Clones in MS Pathogenesis
    GREGORY PARKS OWENS; Fiscal Year: 2013
    ..Identification of pathogenic MS-specific antigen(s) will have wide application, not only for early definitive diagnosis, but also for developing strategies to modulate and possibly prevent disease. ..
  25. Immunotherapy against tauopathy in a transgenic mouse model
    David Morgan; Fiscal Year: 2013
    ..These experiments will use antibodies that bind to the tau protein in an attempt to eliminate it from the brain. This may lead to use of similar antibodies or possible vaccines to treat patients with these diseases. ..
  26. Synthetic Gypsogenin Saponins as Synergistic Vaccine Adjuvants
    ASHISH KUMAR PATHAK; Fiscal Year: 2013
    ..The outcome of this proposal can also facilitate the development of saponin analogs that can stimulate mucosal immunity for potential improvement in nasal delivery of vaccines. ..
  27. POLLEN GRAINS AS TROJAN HORSES FOR ORAL VACCINATION
    Harvinder Singh Gill; Fiscal Year: 2012
    ..Anti-ovalbumin immunoglobulin G (IgG) antibodies were produced in mouse serum after the vaccination...
  28. Combination immunotherapy for neuroblastoma: model of innate tumor immunity
    Shakeel Modak; Fiscal Year: 2013
    ..Correlating donor-recipient KIR/HLA effects with outcome will clarify donor prioritization algorithms and provide prognostic value for future NK immunotherapy studies. ..
  29. Antibody immunotherapeutics for biodefense against Lassa virus
    Robert F Garry; Fiscal Year: 2013
    ..This proposed effort will result in a new class of immunotherapeutics for LF. ..
  30. ETIOLOGY AND PATHOGENESIS OF PEMPHIGUS
    Luis A Diaz; Fiscal Year: 2013
    ..In parallel, new epitope-specific immunoassays and potential novel therapeutic interventions may evolve from these studies. ..
  31. Cetuximab Therapy of Pancreatic Cancer: Immune Modulation with IL-21
    William E Carson; Fiscal Year: 2010
    ..bound mAbs may also activate innate immune cells that bear receptors (R) for the Fc or "constant" region of immunoglobulin G. Our group has demonstrated in vitro, in murine models, and in phase I clinical trials that activating ..
  32. Targeting host response to DAMP for therapy of Rheumatoid Arthritis
    Dexing Fang; Fiscal Year: 2011
    ....
  33. Therapeutic Immunoregulation Mediated by TGF-beta-induced iTregs in Autoimmune Ar
    Song Guo Zheng; Fiscal Year: 2013
    ..If successful, this project will also have a direct clinical relevance and possibly provide a novel approach to treat RA and other autoimmune diseases which may not have the severe side effect(s) characteristic of current therapies. ..
  34. Role of autoantibody isotype in pemphigus pathogenesis
    Aimee S Payne; Fiscal Year: 2013
    ..As similar isotype profiles occur in pemphigoid, epidermolysis bullosa acquisita, and other chronic autoimmune conditions, our studies may have therapeutic relevance for a broad range of autoantibody-mediated diseases. ..
  35. IL-4 Signal Transduction
    JOHN D COLGAN; Fiscal Year: 2013
    ..Our application proposes to study the role of one Interleukin-4 -inducible gene, called NFIL3 gene, that appears to be essential for allergic immune responses in mice. ..
  36. Absorption of maternal antibodies from the gastrointestinal tract
    Lynn Puddington; Fiscal Year: 2012
    ..Our preliminary data challenge fundamental concepts in the basic understanding of the biology of FcRn, a molecular target with tremendous therapeutic potential to positively impact health in children and adults. ..
  37. Role of PLA2R and anti-PLA2R in idiopathic membranous nephropathy
    David J Salant; Fiscal Year: 2013
    ..Approach: Pretransplant and serial post-transplant sera from patients with idiopathic MN will be tested to determine if the presence of anti-PLA2R antibodies predates and presages the recurrence of MN. ..
  38. Activation and regulation of autoreactive B cells in health and disease
    Mark J Shlomchik; Fiscal Year: 2012
    ..Since B cells are absolutely required for these diseases, and depleting them can induce remission in humans, this work is at the crux of understanding how autoimmune diseases like lupus occur and how to better treat them. ..
  39. Adaptive immunity against Pneumocystis
    Chad Steele; Fiscal Year: 2013
    ..murina lung infection and (2) define the role of B cells in the development of local and systemic CD4+ T cell responses during P. murina lung infection. ..
  40. Mucosal dendritic cell function following enteric virus infection
    Christopher F Cuff; Fiscal Year: 2010
    ..This project will improve knowledge of how the intestinal immune system initially responds to enteric viruses, and this information will aid in development of vaccines against viruses that invade through the gastrointestinal tract. ..
  41. Chimeric IgG/A Tumor Immunotherapy
    KEITH WYCOFF; Fiscal Year: 2013
    ..Our collaborators at the University of Pennsylvania will evaluate the ability of these recombinant antibodies to shrink HER2-expressing syngeneic tumors in transgenic mice expressing both HER2/neu and human Fc?RI. ..
  42. Ehrlichia chaffeensis protective proteins
    David H Walker; Fiscal Year: 2010
    ..chaffeensis. ..
  43. Plasma Serum Based Biomarkers in Sublingual Oral Immunotherapy for Milk Allergy
    John T Schroeder; Fiscal Year: 2013
    ....
  44. Clinical Translation of an Anti-Metastatic Antibody for Breast Cancer Therapy
    Kate Rittenhouse-Olson; Fiscal Year: 2013
    ..Phase III studies will involve clinical testing. Potential partnering or out-licensing points for pharmaceutical company facilitation of commercialization of JAA-F11 can occur after each completed phase of the overall project. ..
  45. Zona Pellucida: Immunopathologic Study
    Kenneth S K Tung; Fiscal Year: 2013
    ..Our study will define many Treg functions relevant to many common human diseases such as: pemphigus vulgaris, IC disease (SLE), Sjogren's syndrome, APS1, gastritis, and male and female idiopathic infertility due to gonadal failure. ..
  46. Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
    Wayne G Shreffler; Fiscal Year: 2009
    ..It has been shown that OIT can induce the production of allergen-specific immunoglobulin G (IgG) antibody...
  47. Genetic Modifiers of Immune Evasion by Cytomegalovirus in Glioblastoma
    Janardan P Pandey; Fiscal Year: 2013
    ..Results from the proposed investigation are likely to open a new avenue of investigation in a malignancy that kills approximately 13000 people every year in the U.S. alone. ..
  48. Preclinical development of recombinant antigen diagnostics for Lassa fever
    Robert F Garry; Fiscal Year: 2013
    ..1 we will development commercial Lassa fever recombinant antigen-capture and immunoglobulin M (IgM) and immunoglobulin G (IgG) antibody-capture ELISA using a Performance Panel of well-characterized sera...
  49. Tr1-Specific Tolerance: a Novel Treatment of Multiple Sclerosis
    Kanneganti Murthy; Fiscal Year: 2012
    ..These studies will use a combination of actively induced and transfer models of EAE employing myelin-specific 5B6 PLP139-151-specific TCR transgenic T cells. ..
  50. Endosomal TLRs and their accessory proteins: cell biology and biochemistry
    Hidde L Ploegh; Fiscal Year: 2013
    ..Aim 3: The molecular determinants of UNC93B1 required for trafficking, interaction and activation of TLRs will be examined, making use of new chemoenzymatic tools to study its topology and interacting partners. ..
  51. Humanized Monoclonal Antibodies to Treat Acinetobacter Infections
    Brad J Spellberg; Fiscal Year: 2013
    ..Progression to Phase II depends on humanization of the MAbs without loss of efficacy. ..
  52. Mechanism of Potent Neutralization of HIV by IgA CD4i Antibody
    Lisa A Cavacini; Fiscal Year: 2013
    ....
  53. High throughput screening of bacterial collections for surface proteins of commer
    Roy H Hammerstedt; Fiscal Year: 2010
    ..When successfully implemented, an enhanced method for assessing both new clinical paradigms [such as use of biotherapeutics] as well as improving old analyses [suboptimal diagnostic immunoassays] will be attained. ..
  54. FcRn-targeted mucosal HIV vaccine
    Xiaoping Zhu; Fiscal Year: 2013
    ....
  55. The interdependence between T and B cells in Th2 cell differentiation
    Markus Mohrs; Fiscal Year: 2012
    ..Understanding the fundamental mechanisms of Th2 cell differentiation is a prerequisite for the development of more efficient vaccines and the amelioration of asthmatic, allergic, and atopic disorders. ..
  56. Protective Human Anti-Candida Antibodies
    Mason X Zhang; Fiscal Year: 2013
    ..These insights are valuable to the development of human protective antimannan antibodies for immunoprophylactic and immunotherapeutic applications. ..
  57. Humoral immune profiles at progressive time-points before and after cessation of
    Nidia Rizzo; Fiscal Year: 2013
    ..Study results and the humoral immune pattern strategy developed may be adjusted and applied to other endemic regions of the world where onchocerciasis is still endemic, even during or after stopping MDAI. ..
  58. Mechanistic studies of FcRn inhibitors for the treatment of IgG-mediated diseases
    ELIZABETH SALLY WARD; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The regulation of immunoglobulin G (IgG) levels in vivo represents a fundamental aspect of humoral immunity...
  59. Targeted Treatment of Recurrent Small Cell Lung Cancer with Anti-AbnV2 Antibodies
    Roy H L Pang; Fiscal Year: 2013
    ..The proposed research is expected to rapidly lead to new and successful therapeutic approaches for managing recurrent small-cell lung cancer. ..
  60. Novel methods for high-level expression of aglycosylated or fully glycosylated mo
    Paul Colussi; Fiscal Year: 2010
    ..This project will develop novel expression technology for the production of monoclonal antibodies that will substantially increase product safety and efficacy and decrease cost of goods sold compared to current production methods. ..
  61. PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONS
    Arturo Casadevall; Fiscal Year: 2013
    ....
  62. IMMUNOMODULATION BY EXOGENOUS STREPTOCOCCAL ANTIBODY
    L Jeannine Brady; Fiscal Year: 2010
    ..abstract_text> ..
  63. B. anthracis: passive immunization with anticapsular mAb
    Thomas R Kozel; Fiscal Year: 2012
    ..This information will be critical to decisions made in formulation of a new-generation anthrax vaccine or the design of genetically engineered antibodies to treat anthrax in humans. ..
  64. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2001
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  65. INTESTINAL & PLACENTAL FC-RECEPTORS FOR IMMUNOGLOBULIN
    Neil Simister; Fiscal Year: 2000
    ..In suckling rats and mice, a receptor for the Fc region of immunoglobulin G (IgG) transports IgG from milk across the intestinal epithelium into the blood (FcRn, n for neonate)...
  66. Soluble TCR-IL15 Fusions as Targeted Therapeutics for Cancer
    Peter Rhode; Fiscal Year: 2009
    ..Ultimately, this approach may provide a safer and more effective treatment for patients with cancer than the currently approved immunotherapies. ..
  67. Liver Disease and Drug Use in the HAART Era
    Chloe Thio; Fiscal Year: 2009
    ..Recently, Dr. Mehta and colleagues demonstrated that glycosylation of immunoglobulin G reactive to the heterophilic alpha-gal epitope increases with advancing liver disease...
  68. MODULATORY NETWORK COMPONENETS IN JAPONICA
    GLENN OLDS; Fiscal Year: 1990
    ..In addition such experiments should add to a growing body of knowledge that suggests that network interactions (idiotypic/anti-idiotypic) play important roles in the immune response to infectious pathogens...
  69. GENETIC CONTROL OF ANTIBODY RESPONSES TO POLYSACCHARIDES
    Dan Granoff; Fiscal Year: 1993
    ..The results of these studies will indicate whether individuals with similar levels of total IgG antibody but different subclass distributions are equally protected against Hib disease...
  70. IMMUNOTOXICITY OF ACID ANHYDRIDES IN THE LUNG
    JEAN REGAL; Fiscal Year: 1999
    ..These studies will determine if cytophilic Ab can evoke participation of the complement system and if cytophilic plus non-cytophilic Ab can predict the immunotoxic response. ..
  71. IGG1 AND IGE RECEPTOR MECHANISMS IN LUNG
    Frank Graziano; Fiscal Year: 1992
    ....