immunoglobulin a

Summary

Summary: Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

Top Publications

  1. pmc Immunoglobulin responses at the mucosal interface
    Andrea Cerutti
    ICREA, Catalan Institute for Research and Advanced Studies, Barcelona Biomedical Research Park, Spain
    Annu Rev Immunol 29:273-93. 2011
  2. ncbi Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    J Rodrigo Mora
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 314:1157-60. 2006
  3. ncbi Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    M Muramatsu
    Department of Medical Chemistry, Graduate School of Medicine, Institute for Virus Research, Kyoto University, Japan
    Cell 102:553-63. 2000
  4. ncbi Dermatitis herpetiformis. Part I. Epidemiology, pathogenesis, and clinical presentation
    Diana Bolotin
    Section of Dermatology, The University of Chicago, Chicago, Illinois 60637, USA
    J Am Acad Dermatol 64:1017-24; quiz 1025-6. 2011
  5. ncbi Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
    Satoshi Uematsu
    Laboratory of Host Defense, Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 9:769-76. 2008
  6. ncbi DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    Mikhail B Litinskiy
    Division of Molecular Immunology, Department of Pathology and Laboratory Medicine, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:822-9. 2002
  7. ncbi Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
    Masayuki Tsuji
    Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Immunity 29:261-71. 2008
  8. ncbi Progress in molecular and genetic studies of IgA nephropathy
    J Novak
    Department of Microbiology, University of Alabama at Birmingham, 35294, USA
    J Clin Immunol 21:310-27. 2001
  9. pmc The pathophysiology of IgA nephropathy
    Hitoshi Suzuki
    Department of Internal Medicine, Division of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan
    J Am Soc Nephrol 22:1795-803. 2011
  10. ncbi Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL
    Bing He
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Immunity 26:812-26. 2007

Detail Information

Publications377 found, 100 shown here

  1. pmc Immunoglobulin responses at the mucosal interface
    Andrea Cerutti
    ICREA, Catalan Institute for Research and Advanced Studies, Barcelona Biomedical Research Park, Spain
    Annu Rev Immunol 29:273-93. 2011
    ....
  2. ncbi Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells
    J Rodrigo Mora
    CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Science 314:1157-60. 2006
    Normal intestinal mucosa contains abundant immunoglobulin A (IgA)-secreting cells, which are generated from B cells in gut-associated lymphoid tissues (GALT)...
  3. ncbi Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    M Muramatsu
    Department of Medical Chemistry, Graduate School of Medicine, Institute for Virus Research, Kyoto University, Japan
    Cell 102:553-63. 2000
    ..These results suggest that AID may be involved in regulation or catalysis of the DNA modification step of both class switching and somatic hypermutation...
  4. ncbi Dermatitis herpetiformis. Part I. Epidemiology, pathogenesis, and clinical presentation
    Diana Bolotin
    Section of Dermatology, The University of Chicago, Chicago, Illinois 60637, USA
    J Am Acad Dermatol 64:1017-24; quiz 1025-6. 2011
    ..Based upon our experience with DH and a comprehensive literature review, we provide an update of DH epidemiology, pathophysiology, and clinical presentation...
  5. ncbi Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
    Satoshi Uematsu
    Laboratory of Host Defense, Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Immunol 9:769-76. 2008
    ..When stimulated by the TLR5 ligand flagellin, TLR5(+) LPDCs induced the differentiation of naive B cells into immunoglobulin A-producing plasma cells by a mechanism independent of gut-associated lymphoid tissue...
  6. ncbi DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
    Mikhail B Litinskiy
    Division of Molecular Immunology, Department of Pathology and Laboratory Medicine, Joan and Sanford I Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Nat Immunol 3:822-9. 2002
    ..By eliciting CD40-independent Ig class switching and plasmacytoid differentiation, BLyS and APRIL critically link the innate and adaptive immune responses...
  7. ncbi Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
    Masayuki Tsuji
    Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Immunity 29:261-71. 2008
    b>Immunoglobulin A (IgA) is generated in the gut by both T cell-dependent and T cell-independent processes. The sites and the mechanisms for T cell-independent IgA synthesis remain elusive...
  8. ncbi Progress in molecular and genetic studies of IgA nephropathy
    J Novak
    Department of Microbiology, University of Alabama at Birmingham, 35294, USA
    J Clin Immunol 21:310-27. 2001
    ..Recent progress in molecular analyses of IgA nephropathy thus defines this disease as an autoimmune process with a novel IgA mesangial receptor and certain genetically determined traits...
  9. pmc The pathophysiology of IgA nephropathy
    Hitoshi Suzuki
    Department of Internal Medicine, Division of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan
    J Am Soc Nephrol 22:1795-803. 2011
    ..Elucidation of the pathogenesis of IgA nephropathy provides an opportunity to develop disease-specific therapies...
  10. ncbi Intestinal bacteria trigger T cell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL
    Bing He
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Immunity 26:812-26. 2007
    ..shortly after birth and thereafter exert several beneficial functions, including induction of protective immunoglobulin A (IgA) antibodies...
  11. ncbi The immune geography of IgA induction and function
    A J MacPherson
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Mucosal Immunol 1:11-22. 2008
    The production of immunoglobulin A (IgA) in mammals exceeds all other isotypes, and it is mostly exported across mucous membranes...
  12. ncbi The function of immunoglobulin A in immunity
    Jenny M Woof
    Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, UK
    J Pathol 208:270-82. 2006
    ..b>Immunoglobulin A (IgA), as the principal antibody class in the secretions that bathe these mucosal surfaces, acts as an ..
  13. ncbi Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
    Hiroyuki Tezuka
    Department of Immunology, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Nature 448:929-33. 2007
    ..The presence of a naturally occurring TNF-alpha/iNOS-producing dendritic-cell subset may explain the predominance of IgA production in the MALT, critical for gut homeostasis...
  14. pmc Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies
    M Tomana
    Department of Medicine, Division of Clinical Immunology and Rheumatology, The University of Alabama Birmingham, Birmingham, Alabama 35294 2041, USA
    J Clin Invest 104:73-81. 1999
    ..Our results suggest that the deficiency of Gal in the hinge region of IgA1 molecules results in the generation of antigenic determinants containing GalNAc residues that are recognized by naturally occurring IgG and IgA1 antibodies...
  15. pmc Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity
    Hitoshi Suzuki
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 119:1668-77. 2009
    ..Collectively, these findings indicate that glycan-specific antibodies are associated with the development of IgAN and may represent a disease-specific marker and potential therapeutic target...
  16. ncbi Mucosal IgA responses in influenza virus infections; thoughts for vaccine design
    Elly van Riet
    Influenza Virus Research Centre, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
    Vaccine 30:5893-900. 2012
    ..Here, the current knowledge on the induction of IgA, the role of influenza specific IgA producing B-cells in anti-influenza immunity as well as the role of humoral memory responses induced upon vaccination will be reviewed...
  17. pmc Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Schönlein purpura nephritis
    Krzysztof Kiryluk
    Division of Nephrology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Kidney Int 80:79-87. 2011
    ..Thus, serum galactose-deficient IgA1 levels are highly inherited in pediatric patients with IgAN and HSPN, providing support for another shared pathogenic link between these disorders...
  18. ncbi Marked differences in fine specificity and isotype usage of the anti-citrullinated protein antibody in health and disease
    Andreea Ioan-Facsinay
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 58:3000-8. 2008
    ..In order to identify the features that could confer its pathogenicity, we extensively characterized this antibody response in a unique North American native population of patients with RA and their unaffected relatives...
  19. pmc The biology of intestinal immunoglobulin A responses
    Andrea Cerutti
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, and Weill Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Immunity 28:740-50. 2008
    ..feature of intestinal adaptive immunity is its ability to generate massive amounts of noninflammatory immunoglobulin A (IgA) antibodies through multiple follicular and extrafollicular pathways that operate in the presence or ..
  20. ncbi TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo
    B B Cazac
    Department of Medicine, The Windeyer Institute of Medical Sciences, University College, London, United Kingdom
    Immunity 13:443-51. 2000
    ..The data reveal differential roles of TbetaR in homeostasis and antigen responsiveness of B cell subpopulations and establish a critical function of the TGF-beta receptor ligand pair in the induction of IgA responses in vivo...
  21. ncbi The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fcα receptor interactions
    T S Mattu
    Department of Biochemistry, Oxford University, United Kingdom
    J Biol Chem 273:2260-72. 1998
    ..This also suggests why in contrast to IgG Fc, the IgA1 N-glycans are not undergalactosylated in rheumatoid arthritis...
  22. pmc Impaired IgA class switching in APRIL-deficient mice
    Emanuela Castigli
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:3903-8. 2004
    ..APRIL by itself induced IgA as well as IgG1 isotype switching in CD40-deficient IgM(+)IgD(+) sorted B cells. These results suggest that APRIL down-regulates T cell-dependent antibody responses and promotes IgA class switching...
  23. ncbi Regulation of intestinal homeostasis by dendritic cells
    Hiroyuki Tezuka
    Department of Biodefense Research, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Immunol Rev 234:247-58. 2010
    ..paradoxical situation and maintaining the complex homeostasis in the gut, which includes the induction of immunoglobulin A (IgA) synthesis...
  24. pmc A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts
    Melissa Dullaers
    Baylor Institute for Immunology Research, Baylor Research Institute and INSERM 899, Dallas, TX 75204, USA
    Immunity 30:120-9. 2009
    Mucosal immunoglobulin A (IgA) secreted by local plasma cells (PCs) is a critical component of mucosal immunity...
  25. ncbi Fibrillar IgA deposition in dermatitis herpetiformis--an underreported pattern with potential clinical significance
    Christine J Ko
    Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA
    J Cutan Pathol 37:475-7. 2010
    ..Dermatitis herpetiformis may have a fibrillar rather than granular pattern of IgA deposition on direct immunofluorescent microscopy, and patients with this pattern of immunoglobulin deposition may lack circulating autoantibodies...
  26. pmc The regulation of IgA class switching
    Andrea Cerutti
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, and Weill Graduate School of Medical Sciences of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Rev Immunol 8:421-34. 2008
    ..A better understanding of these mechanisms may help in the development of more effective mucosal vaccines...
  27. ncbi Clinical, pathologic, and immunopathologic features of dermatitis herpetiformis: review of the Mayo Clinic experience
    Javier Alonso-Llamazares
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA
    Int J Dermatol 46:910-9. 2007
    ....
  28. pmc 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production
    David R Bauman
    Department of Molecular Genetics and The Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 106:16764-9. 2009
    ..The suppression of IgA class switching in B cells by a macrophage-derived sterol in response to TLR activation provides a mechanism for local and systemic negative regulation of the adaptive immune response by the innate immune system...
  29. pmc Passive protection with immunoglobulin A antibodies against tuberculous early infection of the lungs
    Ann Williams
    Health Protection Agency, Porton Down, Centre for Applied Microbiology and Research CAMR, Salisbury, UK
    Immunology 111:328-33. 2004
    We report on a new approach toward protection against tuberculosis, based on passive inoculation with immunoglobulin A (IgA) antibodies...
  30. pmc IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1
    Hitoshi Suzuki
    University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Clin Invest 118:629-39. 2008
    ..Thus, our data suggest that premature sialylation likely contributes to the aberrant IgA1 glycosylation in IgA nephropathy and may represent a new therapeutic target...
  31. pmc Immunization with Vibrio cholerae outer membrane vesicles induces protective immunity in mice
    Stefan Schild
    Department of Molecular Biology and Microbiology, Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Infect Immun 76:4554-63. 2008
    ..The induction of specific isotypes, however, was dependent on the immunization route. Immunoglobulin A, for example, was induced to a significant level only by mucosal immunization, with the intranasal route ..
  32. ncbi Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract
    Kathryn B Renegar
    Division of Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 173:1978-86. 2004
    ....
  33. ncbi IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Kidney Int 67:504-13. 2005
    ..Sera of patients with IgA nephropathy (IgAN) contain circulating immune complexes (CIC) composed of galactose-deficient IgA1 complexed with antiglycan antibodies. The role of these CIC in the pathogenesis of IgAN is not known...
  34. ncbi Serologic markers of Epstein-Barr virus infection and nasopharyngeal carcinoma in Taiwanese men
    Y C Chien
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    N Engl J Med 345:1877-82. 2001
    ..CONCLUSIONS: IgA antibodies against EBV capsid antigen and neutralizing antibodies against EBV DNase are predictive of nasopharyngeal carcinoma...
  35. ncbi Prevalence of Celiac disease among children in Finland
    Markku Maki
    Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    N Engl J Med 348:2517-24. 2003
    ....
  36. pmc Poliovirus Sabin type 1 neutralization epitopes recognized by immunoglobulin A monoclonal antibodies
    L Fiore
    Laboratorio di Virologia, Istituto Superiore di Sanita, Rome, Italy
    J Virol 71:6905-12. 1997
    ..Although the production of local secretory immunoglobulin A (IgA) antibody in the gut mucosa may play a major role in protection, most of information about the antigenic ..
  37. pmc The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells
    Edward P Bowman
    Laboratory of Immunology and Vascular Biology, Department of Pathology and the Digestive Disease Center, Stanford University Medical School, Stanford, CA 94305 8444, USA
    J Exp Med 195:269-75. 2002
    b>Immunoglobulin A (IgA) provides protection against pathogens at mucosal surfaces. Chemotactic responses have been hypothesized to target IgA plasma cells involved in mucosal immune responses...
  38. ncbi Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy
    Y Hiki
    Department of Medicine, Daiko Medical Center, Nagoya University, Nagoya, Aichi, Japan
    Kidney Int 59:1077-85. 2001
    ..Our study was conducted to investigate the O-glycan structure in the glomerular IgA1 in IgAN...
  39. ncbi Paucity of antigen-specific IgA responses in sera and external secretions of HIV-type 1-infected individuals
    Jiri Mestecky
    Departments of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    AIDS Res Hum Retroviruses 20:972-88. 2004
    ..Therefore, in striking contrast to other mucosally encountered microbial infections, HIV-1 does not induce vigorous specific IgA responses in any body fluid examined or in ASC in peripheral blood...
  40. ncbi Glycosylation of IgA1 and pathogenesis of IgA nephropathy
    Jan Novak
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Semin Immunopathol 34:365-82. 2012
    ..Studies of molecular defects of IgA1 can define new biomarkers specific for IgA nephropathy that can be developed into clinical assays to aid in the diagnosis, assessment of prognosis, and monitoring of disease progression...
  41. ncbi Plasma-cell homing
    Eric J Kunkel
    BioSeek, Inc, Burlingame, California 94010, USA
    Nat Rev Immunol 3:822-9. 2003
    ..By directing plasma-cell homing, chemokines might help to determine the character and efficiency of mucosal, inflammatory and systemic antibody responses...
  42. ncbi Novel functions of the polymeric Ig receptor: well beyond transport of immunoglobulins
    Armelle Phalipon
    Unite de Pathogenie Microbienne Moleculaire, INSERM U 389, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Trends Immunol 24:55-8. 2003
    ..The multiple mechanisms that they are involved in make pIgR and SC instrumental to mucosal immunity...
  43. pmc IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy
    Jan Novak
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Semin Nephrol 28:78-87. 2008
    ..By using sophisticated analytic methods, it may be possible to define biomarkers for diagnostic purposes and identify new therapeutic targets for a future disease-specific therapy...
  44. ncbi Structure and function relationships in IgA
    J M Woof
    Medical Research Institute, University of Dundee Medical School, Dundee, UK
    Mucosal Immunol 4:590-7. 2011
    b>Immunoglobulin A (IgA) has a critical role in immune defense particularly at the mucosal surfaces, and is equipped to do so by the unique structural attributes of its heavy chain and by its ability to polymerize...
  45. pmc Clustered O-glycans of IgA1: defining macro- and microheterogeneity by use of electron capture/transfer dissociation
    Kazuo Takahashi
    Biomedical FT ICR MS Laboratory, Department of Biochemistry and Molecular Genetics, University of Alabama, Birmingham, Alabama 35294 0005, USA
    Mol Cell Proteomics 9:2545-57. 2010
    ..Furthermore, this work offers generally applicable principles for the analysis of clustered sites of O-glycosylation...
  46. pmc Intestinal bacteria condition dendritic cells to promote IgA production
    Joanna C Massacand
    Environmental Biomedicine, Institute of Integrative Biology, Swiss Federal Institute of Technology, Zurich Schlieren, Switzerland
    PLoS ONE 3:e2588. 2008
    ..These data indicate that exposure to pathogen-associated molecular patterns present on intestinal commensal bacteria condition DC to express a unique molecular footprint that in turn allows them to promote IgA production...
  47. ncbi Serum IL-8 in patients with dermatitis herpetiformis is produced in response to dietary gluten
    Russell P Hall
    Division of Dermatology, Department of Medicine, Duke University Medical Center, Durham VA Medical Center, Durham, North Carolina 27710, USA
    J Invest Dermatol 127:2158-65. 2007
    ..These observations suggest that the IL-8 in the serum of patients with DH originates from the small bowel as a mucosal immune response to gluten ingestion...
  48. pmc Immunoglobulin A antibodies against ricin A and B subunits protect epithelial cells from ricin intoxication
    Nicholas J Mantis
    Division of Infectious Disease, Wadsworth Center, N Y State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    Infect Immun 74:3455-62. 2006
    ..While mucosal immunity to ricin correlates with secretory immunoglobulin A (IgA) antibody levels in vivo, the potential of IgA to protect epithelial cells from ricin in vitro has not ..
  49. ncbi Prediction of clinical and mucosal severity of coeliac disease and dermatitis herpetiformis by quantification of IgA/IgG serum antibodies to tissue transglutaminase
    Ingrid Dahlbom
    Department of Women s and Children s Health Paediatrics, Uppsala University, Uppsala, Sweden
    J Pediatr Gastroenterol Nutr 50:140-6. 2010
    ..We analysed whether the quantification of autoantibodies against tissue transglutaminase could be used to predict mucosal destruction and disease severity in patients with gluten sensitivity...
  50. pmc Selective IgA deficiency
    Leman Yel
    University of California, Irvine, Irvine, CA, USA
    J Clin Immunol 30:10-6. 2010
    b>Immunoglobulin A (IgA) deficiency is the most common primary immunodeficiency defined as decreased serum level of IgA in the presence of normal levels of other immunoglobulin isotypes...
  51. ncbi The human immunoglobulin A Fc receptor FcαRI: a multifaceted regulator of mucosal immunity
    J E Bakema
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Mucosal Immunol 4:612-24. 2011
    b>Immunoglobulin A (IgA) is commonly recognized as the most prevalent antibody (Ab) at mucosal sites with an important role in defense by shielding mucosal surfaces from invasion by pathogens...
  52. pmc Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy
    Ali G Gharavi
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 W 168th Street, P and S 10 445 New York, New York 10032, USA
    J Am Soc Nephrol 19:1008-14. 2008
    ..The fact that abnormal IgA1 glycosylation clusters in most but not all families suggests that measuring Gd-IgA1 may help distinguish patients with different pathogenic mechanisms of disease...
  53. ncbi Autoantibodies against epidermal transglutaminase are a sensitive diagnostic marker in patients with dermatitis herpetiformis on a normal or gluten-free diet
    Christian Rose
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    J Am Acad Dermatol 61:39-43. 2009
    ..Patients with DH demonstrate circulating IgA antibodies against epidermal transglutaminase (eTG) and tissue transglutaminase (tTG). It has been suggested that eTG is the autoantigen of DH...
  54. ncbi Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM
    M Bomsel
    U332 INSERM ICGM, Paris, France
    Immunity 9:277-87. 1998
    ..These results suggest that induction of mucosal immunity to HIV envelope proteins may impair the transcytotic route of HIV mucosal transmission...
  55. ncbi Activation of podocytes by mesangial-derived TNF-alpha: glomerulo-podocytic communication in IgA nephropathy
    Kar Neng Lai
    Dept of Medicine, Rm 411, Professorial Block, Queen Mary Hospital, Univ of Hong Kong, Hong Kong
    Am J Physiol Renal Physiol 294:F945-55. 2008
    ....
  56. ncbi Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis
    Sidonia Fagarasan
    RIKEN Research Center for Allergy Immunology, Yokohama, Japan
    Annu Rev Immunol 28:243-73. 2010
    ..We discuss the finely tuned regulatory mechanisms for IgA production and emphasize the role of mucosal IgA in the selection and maintenance of the appropriate microbial composition that is necessary for immune homeostasis...
  57. ncbi Celiac disease: antibody recognition against native and selectively deamidated gliadin peptides
    M Aleanzi
    Cátedra de Bioquímica Básica de Macromoléculas, INTEBIO, Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Pje el Pozo CC 242, 3000 Santa Fe, Argentina
    Clin Chem 47:2023-8. 2001
    ..We examined the possibility that these modified peptides could be more specific epitopes for circulating antibodies than are native peptides...
  58. ncbi Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease
    Anja Roos
    Department of Clinical Chemistry, Leiden University Medical Center, The Netherlands, and Fonazione D Amico per la Ricerca sulle Malattie Renali, Associazione Nuova Nefrologia, San Carlo Borromeo Hospital, Milano, Italy
    J Am Soc Nephrol 17:1724-34. 2006
    ..Together, these findings strongly point to a role for the lectin pathway of complement in glomerular complement activation in IgAN and suggest a contribution for both MBL and L-ficolin in the progression of the disease...
  59. pmc Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization
    Curtis P Bradney
    Department of Medicine, Human Vaccine Institute, Center for AIDS Research, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Virol 76:517-24. 2002
    ..These results indicate that the proinflammatory cytokines IL-1alpha, IL-12, and IL-18 can replace CT as a mucosal adjuvant for antibody induction and are important candidates for use as mucosal adjuvants with HIV and other vaccines...
  60. ncbi The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut
    Shimpei Kawamoto
    Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama, Tsurumi, Yokohama, Japan
    Science 336:485-9. 2012
    b>Immunoglobulin A (IgA) is essential to maintain the symbiotic balance between gut bacterial communities and the host immune system...
  61. pmc Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria
    Limin Shang
    Immunology Institute, Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 135:529-38. 2008
    ..We hypothesized that TLR signaling at the level of the intestinal epithelium is critical for mucosal immune responses...
  62. ncbi The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut
    Keiichiro Suzuki
    Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Immunity 33:71-83. 2010
    ..germinal centers (GCs) are chronically induced by bacteria and are the major sites for generation of gut immunoglobulin A (IgA) immune responses...
  63. ncbi Sphingosine 1-phosphate regulates the egress of IgA plasmablasts from Peyer's patches for intestinal IgA responses
    Masashi Gohda
    Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Immunol 180:5335-43. 2008
    ..These findings suggest that S1P regulates the retention and emigration of PP B cells and plays key roles in the induction of intestinal IgA production...
  64. ncbi Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels
    Z Moldoveanu
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Kidney Int 71:1148-54. 2007
    b>Immunoglobulin A (IgA) nephropathy is the most prevalent form of glomerulonephritis worldwide. A renal biopsy is required for an accurate diagnosis, as no convenient biomarker is currently available...
  65. ncbi HIV-neutralizing immunoglobulin A and HIV-specific proliferation are independently associated with reduced HIV acquisition in Kenyan sex workers
    Taha Hirbod
    Infectious Diseases Unit, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden
    AIDS 22:727-35. 2008
    HIV-neutralizing immunoglobulin A (IgA) and HIV-specific cellular immunity have been described in highly exposed, persistently seronegative (HEPS) individuals, but well controlled studies have not been performed...
  66. ncbi Interaction of antigens and antibodies at mucosal surfaces
    M E Lamm
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Annu Rev Microbiol 51:311-40. 1997
    ..This review focuses on immunoglobulin A (IgA) antibodies because IgA is the principal mucosal antibody class...
  67. pmc Innate secretory antibodies protect against natural Salmonella typhimurium infection
    Odilia L C Wijburg
    Department of Microbiology and Immunology, The University of Melbourne, VIC 3010, Australia
    J Exp Med 203:21-6. 2006
    ....
  68. pmc Characterization of Vibrio cholerae outer membrane vesicles as a candidate vaccine for cholera
    Stefan Schild
    Howard Hughes Medical Institute and Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Infect Immun 77:472-84. 2009
    ..The detection of an immune response against this heterologously expressed protein is a promising step toward the potential use of OMVs as antigen delivery vehicles in vaccine design...
  69. pmc Scarcity or absence of humoral immune responses in the plasma and cervicovaginal lavage fluids of heavily HIV-1-exposed but persistently seronegative women
    Jiri Mestecky
    Departments of Microbiology and Medicine, University of Alabama at Birmingham, USA
    AIDS Res Hum Retroviruses 27:469-86. 2011
    ..Although HIV-1-infection leads to vigorous IgG responses in plasma and CVL, it does not stimulate sustained IgA responses in either fluid...
  70. ncbi Sublingual grass pollen immunotherapy is associated with increases in sublingual Foxp3-expressing cells and elevated allergen-specific immunoglobulin G4, immunoglobulin A and serum inhibitory activity for immunoglobulin E-facilitated allergen binding to B
    G W Scadding
    National Heart and Lung Institute, Imperial College London, UK
    Clin Exp Allergy 40:598-606. 2010
    ..The mechanisms of sublingual immunotherapy (SLIT) are less well understood than those of subcutaneous immunotherapy (SCIT)...
  71. pmc Oral clarithromycin enhances airway immunoglobulin A (IgA) immunity through induction of IgA class switching recombination and B-cell-activating factor of the tumor necrosis factor family molecule on mucosal dendritic cells in mice infected with influenza
    Etsuhisa Takahashi
    Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima Graduate School, Tokushima, Japan
    J Virol 86:10924-34. 2012
    ..This study identifies that CAM enhances S-IgA production and neutralizing activities through the induction of IgA class switching recombination and upregulation of BAFF molecules in mucosal dendritic cells in IAV-infected mice...
  72. pmc Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages
    Stefan Lohse
    Division of Stem Cell Transplantation and Immunotherapy, Department of Internal Medicine II, Christian Albrechts University, Schittenhelmstrasse 12, 24105 Kiel, Germany
    J Biol Chem 287:25139-50. 2012
    ..In conclusion, these results provide further insight into the immunotherapeutic potential of recombinant IgA antibodies for tumor immunotherapy and suggest macrophages as an additional effector cell population...
  73. pmc Spleen lymphocyte function modulated by a cocoa-enriched diet
    E Ramiro-Puig
    Department of Physiology, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain
    Clin Exp Immunol 149:535-42. 2007
    ..In summary, these results demonstrate the functional activity of a cocoa-high dosage in down-regulating the immune response that might be beneficial in hypersensitivity and autoimmunity...
  74. pmc Dietary fructooligosaccharides up-regulate immunoglobulin A response and polymeric immunoglobulin receptor expression in intestines of infant mice
    Y Nakamura
    Department of Nutritional Research, Nutrition Science Institute, Meiji Dairies Corporation, Kanagawa, Japan
    Clin Exp Immunol 137:52-8. 2004
    ..Taken together, our findings suggest that dietary FOS increases the intestinal IgA response and pIgR expression in the small intestine as well as the colon in infant mice...
  75. pmc Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies
    Carmen Giefing
    Intercell AG, 1030 Vienna, Austria
    J Exp Med 205:117-31. 2008
    ..A vaccine containing PcsB and StkP is intended for the prevention of infections caused by all serotypes of pneumococcus in the elderly and in children...
  76. pmc Small- bowel mucosal changes and antibody responses after low- and moderate-dose gluten challenge in celiac disease
    Marja Leena Lähdeaho
    Paediatric Research Centre and School of Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    BMC Gastroenterol 11:129. 2011
    ..We challenged adult celiac patients with gluten with a view to assessing the amount needed to cause some small-bowel mucosal deterioration...
  77. pmc Differential binding characteristics of native monomeric and polymeric immunoglobulin A1 (IgA1) on human mesangial cells and the influence of in vitro deglycosylation of IgA1 molecules
    Y H Gao
    Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China
    Clin Exp Immunol 148:507-14. 2007
    ..05). The current study suggests differential binding characteristics of native monomeric and polymeric IgA1 on mesangial cells. Glycosylation of IgA1 molecules could significantly affect the binding of IgA1 on HMC...
  78. pmc Passively transmitted gp41 antibodies in babies born from HIV-1 subtype C-seropositive women: correlation between fine specificity and protection
    L Diomede
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
    J Virol 86:4129-38. 2012
    ..Our findings highlight important epitopes in gp41 that appear to be associated with exposure without infection and would be important to consider for vaccine design...
  79. ncbi Effector mechanisms of recombinant IgA antibodies against epidermal growth factor receptor
    Michael Dechant
    Division of Nephrology, University of Schleswig Holstein, Campus Kiel, Schittenhelmstrasse 12, Kiel, Germany
    J Immunol 179:2936-43. 2007
    ..This killing was further enhanced when blood from G-CSF-primed donors was compared with healthy donor blood. Together, these data suggest EGF-R Abs of human IgA isotype to bear promise for therapeutic use in cancer...
  80. pmc Human nasal challenge with Streptococcus pneumoniae is immunising in the absence of carriage
    Adam K A Wright
    Respiratory Infection Group, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Pathog 8:e1002622. 2012
    ..We hypothesise that mucosal exposure alone may not replicate the systemic immunising effect of experimental or natural carriage in humans...
  81. ncbi IgA: an immune glycoprotein
    Esther M Yoo
    Department of Microbiology, Immunology and Molecular Genetics, University of California, 609 Charles E Young Drive, Los Angeles, CA 90095, USA
    Clin Immunol 116:3-10. 2005
    ..In addition, changes in IgA glycosylation are associated with immune pathology. A thorough understanding of the contributions of the glycans to IgA immune protection will aid in the design of clinically suitable antibodies...
  82. pmc Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy
    Douglas D McCarthy
    Department of Immunology, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 121:3991-4002. 2011
    ..These parallels between BAFF-Tg mice and human IgA nephropathy may provide a new framework to explore connections between mucosal environments and renal pathology...
  83. ncbi Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human fcalpha receptor (FcalphaR) CD89
    R J Pleass
    Department of Molecular and Cellular Pathology, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    J Biol Chem 274:23508-14. 1999
    ..We have thus identified motifs in the interdomain region of IgA Fc critical for FcalphaR binding and triggering, significantly enhancing present understanding of the molecular basis of the IgA-FcalphaR interaction...
  84. ncbi The gp41 epitope, QARVLAVERY, is highly conserved and a potent inducer of IgA that neutralizes HIV-1 and inhibits viral transcytosis
    S Jain
    Department of Pathology and Molecular Medicine, Michael G DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
    Mucosal Immunol 4:539-53. 2011
    ....
  85. ncbi Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: observations in three patients
    A C Allen
    Department of Nephrology, Leicester General Hospital, Leicester, England, United Kingdom
    Kidney Int 60:969-73. 2001
    ..This abnormality may potentially contribute to mesangial IgA1 deposition, but this is unproven because the O-glycosylation of mesangial IgA1 has not been analyzed...
  86. ncbi Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA
    Essi Myrsky
    Pediatric Research Center, Medical School, University of Tampere, Tampere, Finland
    Cell Mol Life Sci 66:3375-85. 2009
    ....
  87. ncbi Pathogenetic factors for excessive IgA production: Th2-dominated immune response in canine steroid-responsive meningitis-arteritis
    M Schwartz
    Department of Small Animal Medicine and Surgery, School of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany
    Vet J 187:260-6. 2011
    ..is a systemic inflammatory disease with a predominant manifestation within the cervical meninges, increased immunoglobulin A (IgA) levels in serum and cerebrospinal fluid (CSF), and a shift of the B:T cell ratio towards a higher ..
  88. pmc The N-glycans determine the differential blood clearance and hepatic uptake of human immunoglobulin (Ig)A1 and IgA2 isotypes
    A Rifai
    Department of Pathology, Rhode Island Hospital, Brown University, Providence, Rhode Island 02903, USA
    J Exp Med 191:2171-82. 2000
    ..In addition, dysfunction of the ASGR or altered N-linked glycosylation, but not O-glycans, that affects recognition by this receptor may account for the elevated serum IgA seen in liver disease and IgA nephropathy...
  89. ncbi Antigliadin immunoglobulin A best in finding celiac disease in children younger than 18 months of age
    Carina Lagerqvist
    Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden
    J Pediatr Gastroenterol Nutr 47:428-35. 2008
    ..The aim was to investigate age-dependent serum levels and occurrence of elevated celiac disease (CD)-related antibodies in young children, to define the optimal serological procedure when selecting for small intestinal biopsy...
  90. ncbi Protective immunity in human filariasis: a role for parasite-specific IgA responses
    Bikash R Sahu
    Regional Medical Research Centre, Bhubaneswar, India
    J Infect Dis 198:434-43. 2008
    ..The present study attempts to fill this lacuna...
  91. pmc Cervicovaginal HIV-1-neutralizing immunoglobulin A detected among HIV-1-exposed seronegative female partners in HIV-1-discordant couples
    Robert Y Choi
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    AIDS 26:2155-63. 2012
    Cervicovaginal HIV-1-neutralizing immunoglobulin A (IgA) was associated with reduced HIV-1 acquisition in a cohort of commercial sex workers...
  92. ncbi Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    Andrew J Macpherson
    Institute of Experimental Immunology, Universitatsspital, CH8091 Zurich, Switzerland
    Science 303:1662-5. 2004
    ....
  93. pmc Role of IgA and IgA fc receptors in inflammation
    Renato C Monteiro
    INSERM U699, Paris, France
    J Clin Immunol 30:1-9. 2010
    ..However, IgA can also, when aggregated, be deleterious to the host, inducing inflammatory diseases. This Janus-like nature of IgA is mainly due to their heterogeneity in molecular forms and their interaction with IgA receptors...
  94. pmc Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection
    Taishi Onodera
    Department of Immunology, National Institute of Infectious Diseases, Shinjuku ku, Tokyo 162 8640, Japan
    Proc Natl Acad Sci U S A 109:2485-90. 2012
    ..Our data demonstrates that infected lungs harbor a memory B-cell subset with distinctive phenotype and ability to provide protection against pulmonary virus reinfection...
  95. pmc Diagnostic value of measuring Epstein-Barr virus (EBV) DNA load and carcinoma-specific viral mRNA in relation to anti-EBV immunoglobulin A (IgA) and IgG antibody levels in blood of nasopharyngeal carcinoma patients from Indonesia
    Servi J C Stevens
    Department of Pathology, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Clin Microbiol 43:3066-73. 2005
    ..The circulating EBV DNA load is independent of serological parameters and does not reflect intact tumor cells. The primary diagnostic value of the EBV DNA load for the detection of NPC is limited...
  96. pmc Differential expression of chemokine receptors on human IgA+ and IgG+ B cells
    C Johansson
    Department of Medical Microbiology and Immunology and GUVAX, Göteborg University Vaccine Research Centre, SE 405 30 Goteborg, Sweden
    Clin Exp Immunol 141:279-87. 2005
    ..In contrast, none of the studied chemokine receptors was preferentially expressed by IgA+ cells...
  97. ncbi Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy
    Ivan C Moura
    INSERM U699, Bichat Medical School, 75870 Paris, Cedex 18, France
    J Am Soc Nephrol 16:2667-76. 2005
    ....
  98. ncbi Steroid responsive meningitis-arteritis: a prospective study of potential disease markers, prednisolone treatment, and long-term outcome in 20 dogs (2006-2008)
    M Lowrie
    Division of Companion Animal Sciences, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
    J Vet Intern Med 23:862-70. 2009
    Previous multidrug studies have identified the value of prednisolone in treating steroid responsive meningitis-arteritis (SRMA) and the potential value of acute phase proteins (APPs) and immunoglobulin A (IgA) in diagnosis and monitoring.
  99. ncbi Evidence for local expansion of IgA plasma cell precursors in human ileum
    Saravanan Yuvaraj
    Department of Cell Biology, Section Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Immunol 183:4871-8. 2009
    ..A second wave of expansion of IgA-committed cells occurs locally within the lamina propria as evidenced by the high frequency of clonally related cells...
  100. ncbi Roles of B-1 and B-2 cells in innate and acquired IgA-mediated immunity
    Keiichiro Suzuki
    Laboratory for Mucosal Immunity, RIKEN Research Center for Allergy and Immunology, Tsurumi, Yokohama, Japan
    Immunol Rev 237:180-90. 2010
    ..the most conspicuous responses of the gut immune system following microbial colonization is the production of immunoglobulin A (IgA)...
  101. ncbi Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprue
    Eric V Marietta
    Department of Dermatology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Invest Dermatol 128:332-5. 2008
    ..These results would indicate that intestinal damage is associated with the production of anti-tTG IgA and anti-TGe IgA in DH patients...

Research Grants64

  1. IgA1-Regulation of Complement in Periodontal Disease
    ROBERT BOACKLE; Fiscal Year: 2002
    ....
  2. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..There is evidence that HIV-1 impairs protective immunoglobulin G (IgG) and immunoglobulin A (IgA) responses against pathogens and vaccines by inducing progressive loss of these CD4+ T helper cells...
  3. MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSE
    David R Brown; Fiscal Year: 2010
    ....
  4. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne A Marasco; Fiscal Year: 2010
    ..A protective genetic microbicide delivered to the female lower genital track could dramatically slow the spread of HIV/AIDS. ..
  5. OLFACTORY TOXICITY OF ENVIRONMENTAL AGENTS
    Xinxin Ding; Fiscal Year: 2010
    ..The lateral nasal gland (LNG), which secretes odorant binding proteins and immunoglobulin A to the nasal mucus, is an important organ for the ability to detect odorant signals and for the maintenance ..
  6. Genetic Basis of Non-Familial IgA Nephropathy
    Tongzhong Ju; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Immunoglobulin A (IgA) nephropathy (IgAN) or Berger's disease is an autoimmune disease resulting from the abnormal deposit of IgA in the glomerulus...
  7. IgA Protease as Therapy to Reverse IgA Nephropathy
    Jiazhou Qiu; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Immunoglobulin A (IgA) nephropathy (IgAN) is one of the most common glomerulopathies worldwide, leading to kidney failure in up to 40% of those affected...
  8. Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes
    Jan Novak; Fiscal Year: 2013
    ..Relevance: The results will shed light on the pathogenesis of IgAN and identify therapeutic targets for disease-specific treatment of IgAN as well as potential response/prognostic biomarkers. ..
  9. The association between preterm milk immunobiology and infant health
    MAUREEN EDITH GROER; Fiscal Year: 2013
    ..Secretory Immunoglobulin A concentration will also be assayed...
  10. Chimeric IgG/A Tumor Immunotherapy
    KEITH WYCOFF; Fiscal Year: 2013
    ..Our collaborators at the University of Pennsylvania will evaluate the ability of these recombinant antibodies to shrink HER2-expressing syngeneic tumors in transgenic mice expressing both HER2/neu and human Fc?RI. ..
  11. HUMAN PROTEOLYTIC FOR IgA NEPHROPATHY
    Robert F Balint; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Immunoglobulin A nephropathy (IgAN) is the most common form of glomerulonephritis worldwide...
  12. Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes
    Jan Novak; Fiscal Year: 2012
    ..Relevance: The improved understanding of the pathogenesis of IgAN will identify therapeutic targets for disease-specific therapy of IgAN as well as potential prognostic biomarkers. ..
  13. Analytical tools for the analysis of clustered O-glycans in clinical samples
    Matthew B Renfrow; Fiscal Year: 2013
    ....
  14. Mechanism of Potent Neutralization of HIV by IgA CD4i Antibody
    Lisa A Cavacini; Fiscal Year: 2013
    ....
  15. Th17 cell regulation of intestinal IgA production
    Yingzi Cong; Fiscal Year: 2010
    b>Immunoglobulin A (IgA) has been shown to be critical in mucosal immune defense...
  16. Modulation of Oral Biofilm Development by Secretory IgA and IgA1 Proteases
    Thomas A Brown; Fiscal Year: 2010
    ..An understanding of the role of host immunity on biofilm formation might also lead to salivary diagnostics that could predict susceptibility to development of pathogenic biofilms. ..
  17. Quantitative Genetics of Defective IgA1 Glycosylation in IgA Nephropathy
    Krzysztof Kiryluk; Fiscal Year: 2013
    ..The proposed studies of the genetic defects that result in the production abnormal IgA1 will lay the basis for the development of effective therapies for this serious disease. ..
  18. A GWAS for IgA Nephropathy, the Most Common form of Glomerulonephritis
    Richard P Lifton; Fiscal Year: 2010
    In this study, we propose to perform the first genome-wide association study (GWAS) for Immunoglobulin A Nephropathy (IgAN, OMIM %161950), an understudied disease that is a major cause of kidney failure in the U.S. and worldwide...
  19. Population-based study of serum IgA, IgA1, and galactose-deficient IgA1 levels
    Krzysztof Kiryluk; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Immunoglobulin A (IgA) is an important component of the immune system that provides local defense against mucosal pathogens...
  20. Adaptive Immune Response to Symbiotic Bacteria as a Mediator of Gut Homeostasis
    Daniel A Peterson; Fiscal Year: 2010
    ..I have characterized the specificity of this unique immunoglobulin A (IgA), which was naturally primed by colonization of germfree mice with this bacterium...
  21. IgA1 glycosylation and receptor interactions in IgA nephropathy
    Andrew B Herr; Fiscal Year: 2010
    ..Understanding the molecular interactions underlying IgAN will be the first step towards developing treatments for this costly and debilitating disease. ..
  22. Cross-serotype protection against Streptococcus pneumoniae by induction of neutra
    Edward N Janoff; Fiscal Year: 2012
    ..This early translational study will evaluate the feasibility of incorporating IgA1P as a protein vaccine antigen to facilitate cross-serotype protection against S. pneumoniae colonization, pneumonia and invasive disease. ..
  23. Trafficking of plgR in Lacrimal Gland
    Sarah F Hamm Alvarez; Fiscal Year: 2010
    ..The major antibody present in tears is dimeric IgA (dlgA), which associates with the polymeric immunoglobulin A receptor (plgR) at epithelial cell basolateral membranes...
  24. Elucidating IgA Nephropathy through Genetic Studies of IgA1 Glycosylation
    Jan Novak; Fiscal Year: 2012
    ..The proposed studies will provide the foundation for the future development and testing of disease-specific interventions and advance the quality of care for IgAN patients. ..
  25. GDPrime
    BRUCE MARSHALL ROBINSON; Fiscal Year: 2013
    ..GDPrime) consortium with a focus on minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), immunoglobulin A nephropathy (IGAN), and idiopathic membranous nephropathy (IMN)...
  26. Discovery and fine mapping of susceptibility loci for IgA nephropathy
    Richard P Lifton; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Immunoglobulin A Nephropathy is a major cause of kidney failure worldwide...
  27. Haemophilus Hap-mediated Microcolony Formation
    JOSEPH ST GEME; Fiscal Year: 2002
    ..influenzae disease. Perhaps more importantly, they may provide general insights into host-microbe relationships and expand our understanding of microbial biofilms. ..
  28. Bioactivity and Vitamins in Flash-heated Breastmilk
    Caroline Chantry; Fiscal Year: 2005
    ..samples from HIV-infected mothers: 1) vitamin content and protein digestibility; 2) key bioactive proteins (immunoglobulin A, lysozyme and lactoferrin); 3) antibacterial activity...
  29. DNA Repair Defects in IgA Deficiency
    REUBEN HARRIS; Fiscal Year: 2009
    DNA Repair Defects in IgA Deficiency Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in humans, and it is characterized by the absence of serum IgA and an increased frequency of bacterial infections in the ..
  30. WHOLE GENOME SHOTGUN SEQUENCING OF STREPTOCOCCUS MITIS
    Herve Tettelin; Fiscal Year: 2001
    ..mitis to that of other streptococci, such as the highly virulent, type-4 S. pneumoniae strain, nearing completion at TIGR, allowing the identification of virulence-associated genes. ..
  31. INFECTION IN ELBW INFANTS:PROTECTION WITH MOTHER'S MILK
    Nancy Rodriguez; Fiscal Year: 2005
    ..Selected immunologic factors, such as secretory immunoglobulin A, are absorbed and excreted in the infant's urine; lactoferrin, with enhanced bacteriocidal properties, has ..
  32. IgA-secreting B cell lines: a novel tool for studies of IgA nephropathy
    Jan Novak; Fiscal Year: 2009
    ....
  33. Novel Vaginal Microbicides Based On Stable AAV-Neutralizing Antibody Gene Transfe
    Wayne Marasco; Fiscal Year: 2009
    ..A protective genetic microbicide delivered to the female lower genital track could dramatically slow the spread of HIV/AIDS. ..
  34. Accurate profiles of IgA1 O-glycan heterogeneity in IgA nephropathy
    MATTHEW RENFROW; Fiscal Year: 2009
    ..The results will provide insights into the pathology of the IgAN and may provide a non-invasive method of diagnosing th3disease. ..
  35. HOST DEFENSE FACTORS IN ORAL ECOLOGY
    JOEL RUDNEY; Fiscal Year: 1991
    ..These include lysozyme (Lz), lactoferrin (Lf), salivary peroxidase (Spx), secretory immunoglobulin A (sIgA), the mucin glycoproteins (MG1 and MG2), and others less well known...
  36. Distress, Saliva Composition and Saliva Functions
    JOS BOSCH; Fiscal Year: 2006
    ..the salivary concentration and secretion rate of components of adaptive secretory immunity, such as Secretory Immunoglobulin A (S-lgA) and the S-lgA subclasses; (2) to determine if protracted distress affects the salivary secretion and ..
  37. IGA GLYCANS AND IMMUNE COMPLEXES IN IGA NEPHROPATHY
    Milan Tomana; Fiscal Year: 2004
    ..Results of these studies may lead to the elucidation of molecular defects of IgA1 in IgAN and provide experimental basis for rational approach to the treatment. ..
  38. IGA ANTIBODIES AND PERIODONTAL INFLAMMATION
    Michael Russell; Fiscal Year: 2000
    The objectives of this R01 application are to elucidate the role of immunoglobulin A (IgA) in human periodontal disease, which afflicts significant numbers of adults with increasing age, and is a major cause of tooth loss in the elderly...
  39. SECRETORY IMMUNE SYSTEM - RELATIONSHIP TO OCULAR DISEASE
    RUDOLPH FRANKLIN; Fiscal Year: 1993
    The majority of immunoglobulin in tears is of the immunoglobulin A (IgA) isotype, which is produced mainly by plasma cells of the lacrimal gland...
  40. MOLECULAR ABERRANCIES OF IGA IN IGA NEPHROPATHY
    Milan Tomana; Fiscal Year: 2001
    ..Results of these studies should provide information concerning the behavior of structurally altered IgA1 proteins and provide a rational explanation for their deposition in kidney mesangium of IgAN patients. ..
  41. STRUCTURAL STUDIES OF RECEPTORS IN MUCUOSAL IMMUNITY
    Roland Strong; Fiscal Year: 2000
    ..Multimeric immunoglobulin A (IgA) is the predominant antibody in the mucosa and is transported there, across the epithelium, through a ..
  42. 10-BORON LABELED ANTIBODIES IN CANCER THERAPY
    M Hawthorne; Fiscal Year: 1992
    ..A new hybridoma will be required which recognizes a portion of 20 mer. The Mab derived from this hybridoma will be cleaved to a Fab' and chemically linked to the Fab' derived from anti- CEA T84.66 Mab...
  43. Regulation of lung alveolar epithelial protein transport
    Kwang Jin Kim; Fiscal Year: 2005
    ..saturable processes at rates greater than those predicted by passive diffusional mechanisms, whereas dimeric immunoglobulin A (dIgA) is secreted into alveolar fluid via a polymeric immunoglobulin receptor (pIgR)-mediated process...
  44. RECEPTOR-MEDIATED ENDOCYTOSIS IN HEPATOCYTES
    Ann Hubbard; Fiscal Year: 1990
    ..the rat hepatocyte are being studied: the asialoglycoprotein, epidermal growth factor (EGF) and polymeric immunoglobulin A (pIgA) systems...
  45. FAULTY IMMUNE REGULATION IN AUTISM
    Dennis Odell; Fiscal Year: 2000
    ..Some of the autistic subjects demonstrated decreased levels of immunoglobulin A which also appeared to be associated with a gene within the MHC...
  46. RECOMBINANT ANTIBODIES FOR INFANT PROTECTION
    Sherie Morrison; Fiscal Year: 2004
    ..It also may be possible to use this sequence to target other proteins to the chicken egg. Cloning of the receptor will define its structure and allow us to fully characterize this novel transport system. ..
  47. DEVELOPMENT OF THE SECRETORY IMMUNE SYSTEM
    Albert Jones; Fiscal Year: 1991
    ..Plasma membrane, Immunoglobulin A (IgA) receptor, secretory component (SC), endocytic vesicles and microtubules are vital to immunoglobulin ..
  48. REGULATION OF MUCOSAL IMMUNOCOMPETENCE IN THE AGING RAT
    Christopher Daniels; Fiscal Year: 1991
    ..Furthermore, recent evidence for our laboratory suggests that an age- dependent decline in immunoglobulin A producing cells in the lamina propria of the intestine, and a concomitant decline in nonimmune tissue ..
  49. MUCOSAL DEFENSE BY IGA AGAINST S PNEUMONIAE
    Edward Janoff; Fiscal Year: 2005
    ..pneumoniae in children and adults. ..
  50. SECRETORY IGA SYSTEM--MOLECULAR-CELLULAR INTERACTIONS
    Jiri Mestecky; Fiscal Year: 1990
    ..In contrast to our knowledge of the synthetic sites and large quantitites of IgA produced, its catabolism remains undefined. Accordingly, we shall examine the fate and tissue distribution of catabolized IgA...
  51. A SPLIT-SELECTABLE MARKER FOR MULTIGENE TRANSFORMATIONS
    LLOYD YU; Fiscal Year: 2001
    ..The SSM may also be disabled to yield transgenics with no functional selectable marker. Secretory immunoglobulin A (SIgA) has demonstrated pH and proteolytic stability in the mucosal environment and is tetravalent, making it ..
  52. AGING IMPAIRMENT OF GUT MUCOSAL IMMUNITY
    DOUGLAS SCHMUCKER; Fiscal Year: 1990
    ..significant age- related declines in the hepatobiliary secretion of nonspecific and alpha-cholera toxin immunoglobulin A (IgA) in male rats and attributed this to a concomitant loss of specific IgA receptors from hepatocytes...
  53. KIDNEY INJURY MOLECULE-1 IN RENAL INJURY AND REPAIR
    Zhiwei Zhang; Fiscal Year: 2003
    ..This will help us to better understand the cellular and molecular mechanism involved in renal proximal tubular injury and repair processes and may ultimately lead to new diagnostic and therapeutic approaches in ARF. ..
  54. INTRACELLULAR SURVIVAL MECHANISMS OF NEISSERIA
    Magdalene So; Fiscal Year: 2004
    ..As many other bacterial pathogens secrete proteases of unknown function with similar specificities for human IgA1, her studies may shed light on the function of a large class of bacterial proteases. ..
  55. GENETICS AND PHYSIOLOGY OF GONOCOCCAL IGA PROTEASES
    MARTHA MULKS; Fiscal Year: 1990
    ....
  56. COMPARATIVE ONTOGENETIC APPROACH TO VACCINE STRATEGY
    Max Cooper; Fiscal Year: 1999
    ..These studies of virgin IgM B cells and their IgA1 and IgA2 memory B cell progeny should provide valuable information for the design of vaccine strategy in individuals of various ages. ..
  57. CERVICAL IMMUNITY TO HEAT SHOCK PROTEINS IN CANCER
    Steven Witkin; Fiscal Year: 2002
    ..The results will allow for the evaluation of cervical immunity to hsp27 and hsp9O, as well as the presence of these antigens themselves, as sensitive, noninvasive biomarkers for gynecologic malignancies. ..
  58. CRYOBARIC VIRAL INACTIVATION FOR IMMUNOGLOBULIN
    Feng Tao; Fiscal Year: 2000
    ..Process parameters will be optimized and the viral inactivation rates and therapeutic protein function of IVIG will be measured. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  59. The Effects of Music Therapy-Based Stress Reduction on *
    OLLE JANE SAHLER; Fiscal Year: 2002
    ..and also affect immune function by modulating circulating and salivary levels of such agents as cortisol, immunoglobulin A, interleukin-1, natural killer cells, and a variety of other immune system-related substances...
  60. PROTEOLYTIC MECHANISMS IN HUMAN COLON CONTENTS
    Andrew Plaut; Fiscal Year: 1980
    ..characterization of the IgA protease enzymes produced by them, and the characterization of the fragments of immunoglobulin A resulting from their action...
  61. Cloning Kawasaki Disease-specific antigens
    Anne Rowley; Fiscal Year: 2005
    ..These plans will provide me with opportunities for enhanced career development by acquisition of new research skills, and will be fostered by the strong interdisciplinary research environment at Northwestern. ..
  62. Mucosal immune response to oral cholera vaccine Peru 15
    Firdausi Qadri; Fiscal Year: 2007
    ..cholerae. ..