helminth antibodies

Summary

Summary: Antibodies produced by human or animal cells following clinical or experimental exposure to parasitic HELMINTH ANTIGENS. The IMMUNOGLOBULIN E class of immunoglobulins is usually formed and released, but IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; and IMMUNOGLOBULIN A may also occur.

Top Publications

  1. ncbi Identification of a novel 19 kDa Echinococcus granulosus antigen
    Federica Delunardo
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Acta Trop 113:42-7. 2010
  2. pmc Highlights of human toxocariasis
    J F Magnaval
    Service de Parasitologie, Centre Hospitalier Universitaire Rangueil 31403 Toulouse 4, France
    Korean J Parasitol 39:1-11. 2001
  3. ncbi The relationship between age, sex, egg-count and specific antibody responses against Schistosoma mansoni antigens in a Ugandan fishing community
    Cynthia W A Naus
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, UK
    Trop Med Int Health 8:561-8. 2003
  4. ncbi Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens
    Francisca Mutapi
    Institute for Immunology and Infection Research, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Infect Dis 192:1108-18. 2005
  5. ncbi Antibodies to surface epitopes of the carbohydrate larval antigen CarLA are associated with passive protection in strongylid nematode challenge infections
    G B L Harrison
    AgResearch Ltd, Hopkirk Research Institute, Grasslands Research Centre, Palmerston North, New Zealand
    Parasite Immunol 30:577-84. 2008
  6. pmc Usefulness of four different Echinococcus granulosus recombinant antigens for serodiagnosis of unilocular hydatid disease (UHD) and postsurgical follow-up of patients treated for UHD
    Ana Hernandez-Gonzalez
    IRNASA, CSIC, Cordel de Merinas, 50, 37008 Salamanca, Spain
    Clin Vaccine Immunol 15:147-53. 2008
  7. ncbi Peptides containing T cell epitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of immune response, reduction in liver pathology and partial protection against Schistosoma mansoni infection in mice
    Teresa C M Garcia
    Department of Biochemistry and Immunology and Institute for Investigation in Immunology Millenium Institute, Federal University of Minas Gerais, Avenue Antonio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
    Acta Trop 106:162-7. 2008
  8. pmc Use of enzyme-linked immunosorbent assay and dipstick assay for detection of Strongyloides stercoralis infection in humans
    H Rogier van Doorn
    Department of Medical Microbiology, Academic Medical Center, Room L1 245, P O Box 22660, 1100DD Amsterdam, The Netherlands
    J Clin Microbiol 45:438-42. 2007
  9. ncbi Associations between specific antibody responses and resistance to reinfection in a Senegalese population recently exposed to Schistosoma mansoni
    Kim Vereecken
    Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 12:431-44. 2007
  10. ncbi Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies?
    Michael J Doenhoff
    School of Biological Sciences, University of Wales, Bangor, Gwynedd, Wales, UK LL57 2UW
    Trends Parasitol 20:35-9. 2004

Research Grants

Detail Information

Publications228 found, 100 shown here

  1. ncbi Identification of a novel 19 kDa Echinococcus granulosus antigen
    Federica Delunardo
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Acta Trop 113:42-7. 2010
    ..Even if Eg19 appear to have no benefit in the diagnosis of the disease, our data, confirming the presence of antigens inducing both IgG1 and IgG4 during active development of CE, suggest that Eg19 might be a marker of disease status...
  2. pmc Highlights of human toxocariasis
    J F Magnaval
    Service de Parasitologie, Centre Hospitalier Universitaire Rangueil 31403 Toulouse 4, France
    Korean J Parasitol 39:1-11. 2001
    ..When diagnosed, all of these syndromes require thorough prevention of recontamination (especially by deworming pets) and sanitary education...
  3. ncbi The relationship between age, sex, egg-count and specific antibody responses against Schistosoma mansoni antigens in a Ugandan fishing community
    Cynthia W A Naus
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, UK
    Trop Med Int Health 8:561-8. 2003
    ..IgG4-SEA and IgG4-SWA were both strongly correlated with egg count. Patterns of IgE-SWA responses were qualitatively different to IgG4 responses, suggesting independent pathways of regulation...
  4. ncbi Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens
    Francisca Mutapi
    Institute for Immunology and Infection Research, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Infect Dis 192:1108-18. 2005
    ..This study aimed to identify and compare proteins recognized by serum samples from schistosome-exposed individuals before and after curative praziquantel treatment...
  5. ncbi Antibodies to surface epitopes of the carbohydrate larval antigen CarLA are associated with passive protection in strongylid nematode challenge infections
    G B L Harrison
    AgResearch Ltd, Hopkirk Research Institute, Grasslands Research Centre, Palmerston North, New Zealand
    Parasite Immunol 30:577-84. 2008
    ..The results provide further evidence that the larval surface carbohydrate antigen CarLA has potential as a mucosal immunogen for a strongylid nematode vaccine...
  6. pmc Usefulness of four different Echinococcus granulosus recombinant antigens for serodiagnosis of unilocular hydatid disease (UHD) and postsurgical follow-up of patients treated for UHD
    Ana Hernandez-Gonzalez
    IRNASA, CSIC, Cordel de Merinas, 50, 37008 Salamanca, Spain
    Clin Vaccine Immunol 15:147-53. 2008
    ..4 and 94.2, respectively). In addition, this diagnostic tool proved to be useful for the follow-up of surgically treated UHD patients. The anti-B2t IgG ELISA may find an application in the serodiagnosis of UHD in clinical laboratories...
  7. ncbi Peptides containing T cell epitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of immune response, reduction in liver pathology and partial protection against Schistosoma mansoni infection in mice
    Teresa C M Garcia
    Department of Biochemistry and Immunology and Institute for Investigation in Immunology Millenium Institute, Federal University of Minas Gerais, Avenue Antonio Carlos 6627, Pampulha, Belo Horizonte, MG, Brazil
    Acta Trop 106:162-7. 2008
    ..In contrast, paramyosin peptide vaccination did not engender protective immunity or liver pathology reduction and immunization was associated with a Th2 type of immune response...
  8. pmc Use of enzyme-linked immunosorbent assay and dipstick assay for detection of Strongyloides stercoralis infection in humans
    H Rogier van Doorn
    Department of Medical Microbiology, Academic Medical Center, Room L1 245, P O Box 22660, 1100DD Amsterdam, The Netherlands
    J Clin Microbiol 45:438-42. 2007
    ..0, 97.7, 97.2, and 97.2%, respectively. Our data suggest that all four assays are sensitive and specific tests for the diagnosis of both intestinal and cutaneous strongyloidiasis...
  9. ncbi Associations between specific antibody responses and resistance to reinfection in a Senegalese population recently exposed to Schistosoma mansoni
    Kim Vereecken
    Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 12:431-44. 2007
    ..Resistance to reinfection and production of IgA-SWA was associated with adulthood independently of exposure patterns, suggesting that susceptibility to S. mansoni and the development of protective immune responses is age-dependent...
  10. ncbi Specific and sensitive diagnosis of schistosome infection: can it be done with antibodies?
    Michael J Doenhoff
    School of Biological Sciences, University of Wales, Bangor, Gwynedd, Wales, UK LL57 2UW
    Trends Parasitol 20:35-9. 2004
  11. pmc Current status of vaccines for schistosomiasis
    Donald P McManus
    Molecular Parasitology Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane Q4006, Australia
    Clin Microbiol Rev 21:225-42. 2008
    ..haematobium) and Asian (S. japonicum) schistosomes is then discussed, as are new approaches that may improve the efficacy of available vaccines and aid in the identification of new targets for immune attack...
  12. ncbi A serological study of human toxocariasis in north India
    Nancy Malla
    Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Natl Med J India 15:145-7. 2002
    ....
  13. ncbi Frequency of human toxocariasis in Jos, Plateau State, Nigeria
    O O Ajayi
    Applied Parasitology Laboratory, Department of Zoology, University of Jos, Nigeria
    Mem Inst Oswaldo Cruz 95:147-9. 2000
    ..9% for males. However, the differences were not significant by age and sex. A highly significant association (p < 0.001) was observed between seropositivity and geography but none between seropositivity and dog ownership (p > 0.05)...
  14. pmc Development of a highly specific recombinant Toxocara canis second-stage larva excretory-secretory antigen for immunodiagnosis of human toxocariasis
    H Yamasaki
    Department of Parasitology, Juntendo University School of Medicine, Tokyo, Japan
    J Clin Microbiol 38:1409-13. 2000
    ..From these results, the recombinant antigen is highly specific for toxocariasis and may provide more reliable diagnostic results than other methods...
  15. ncbi Echinococcosis on the Tibetan Plateau: prevalence and risk factors for cystic and alveolar echinococcosis in Tibetan populations in Qinghai Province, China
    P M Schantz
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Parasitology 127:S109-20. 2003
    ....
  16. ncbi Epilepsy and toxocariasis: a case-control study in Italy
    Alessandra Nicoletti
    Department of Neurosciences, University of Catania, Catania, Italy
    Epilepsia 49:594-9. 2008
    ..To assess the relationship between epilepsy and toxocariasis in adult subjects by means of a case-control study in Catania, Italy...
  17. pmc Development of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus
    D Abraham
    Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Infect Immun 69:262-70. 2001
    ..volvulus. Furthermore, since the antigens functioned with alum as the adjuvant, this vaccine could potentially be used clinically to prevent river blindness in humans...
  18. pmc Alveolar echinococcosis: characterization of diagnostic antigen Em18 and serological evaluation of recombinant Em18
    Yasuhito Sako
    Department of Parasitology, Asahikawa Medical College, Japan
    J Clin Microbiol 40:2760-5. 2002
    ..RecEm18 has the potential for use in the differential serodiagnosis of alveolar echinococcosis...
  19. ncbi IL-10 is crucial for the transition from acute to chronic disease state during infection of mice with Schistosoma mansoni
    Clare H Sadler
    Department of Biology, University of York, York, GB
    Eur J Immunol 33:880-8. 2003
    ..It is a crucial agent in the down-modulation of immune responses and immunopathology that defines the transition from acute to chronic disease...
  20. ncbi [Cerebral toxocariasis: a rare cause of cognitive disorders. A contribution to differential dementia diagnosis]
    E Richartz
    Universitätsklinik für Psychiatrie und Psychotherapie Tübingen, Osianderstr 24, 72076 Tubingen
    Nervenarzt 73:458-62. 2002
    ..Taking the toxocara infection as the cause of this patient's cognitive defects, we propose that lumbar punction becomes part of the diagnostic standard in differential diagnosis of dementia...
  21. pmc Differential cytokine and antibody responses to adult and larval stages of Onchocerca volvulus consistent with the development of concomitant immunity
    Angus J MacDonald
    Laboratory of Molecular Parasitology, New York Blood Center, New York, New York 10021, USA
    Infect Immun 70:2796-804. 2002
    ..The separate and distinct cytokine and antibody responses to adult and infective larval stages of O. volvulus which are age related are consistent with the acquisition of concomitant immunity in infected individuals...
  22. pmc A seroepidemiological survey for toxocariasis in apparently healthy residents in Gangwon-do, Korea
    Hyun Young Park
    Department of Parasitology, College of Medicine, Hallym University, Chunchon 200 702, Korea
    Korean J Parasitol 40:113-7. 2002
    ..These results inferred that cross-reactions were negligible between toxocariasis and other helminthiases. Toxocariasis seroprevalence among Korean rural adults was detected to be approximately 5%...
  23. ncbi Development of a rapid, sensitive, dye immunoassay for schistosomiasis diagnosis: a colloidal dye immunofiltration assay
    Xiao Xiang
    Institute of Immunology, School of Life Sciences, University of Science and Technology of China, 443 Huangshan Road, Hefei, Anhui 230027, China
    J Immunol Methods 280:49-57. 2003
    ..The results indicated that the CDIFA provided an economic, simple, rapid, robust test for the detection of schistosome infection, suitable for a wide variety of field applications without any instrumentation...
  24. ncbi Preliminary characterization of an adult worm "vomit" preparation of Schistosoma mansoni and its potential use as antigen for diagnosis
    Sandra Planchart
    Departamento de Parasitologia, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela
    Parasitol Res 101:301-9. 2007
    ..None of the two duplets disappeared after successful chemotherapy during the time of evaluation in mice or humans...
  25. ncbi Molecular characterization of P-29, a metacestode-specific component of Echinococcus granulosus which is immunologically related to, but distinct from, antigen 5
    G Gonzalez
    Cátedra de Inmunología Facultad de Química, Montevideo, Uruguay
    Mol Biochem Parasitol 105:177-84. 2000
    ..Our results prove unequivocally that P-29 and Ag5 are immunologically related, but different proteins, raising several questions on the current knowledge of Ag5...
  26. ncbi Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni
    C L King
    Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, OH 44106, USA
    J Immunol 158:294-300. 1997
    ..These data show that IgE participates in parasite elimination in primary infection with S. mansoni and in the generation of humoral immunity and cytokine responses to the parasite...
  27. ncbi Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile
    D Jankovic
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 163:337-42. 1999
    ..Taken together, these findings argue that tissue pathology in schistosomiasis requires, in addition to egg-specific CD4+ lymphocytes, a previously unrecognized IL-4Ralpha+ non-T cell effector population...
  28. ncbi Immunodiagnostic tools for human and porcine cysticercosis
    Pierre Dorny
    Department of Animal Health, Institute of Tropical Medicine, Nationalestraat 155, B 2000 Antwerp, Belgium
    Acta Trop 87:79-86. 2003
    ..Under these conditions, serology may provide the only tool for diagnosis of the infection...
  29. pmc B cells and antibodies are required for resistance to the parasitic gastrointestinal nematode Trichuris muris
    N M Blackwell
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    Infect Immun 69:3860-8. 2001
    ..Our results as a whole describe the first detailed report of a critical role for B cells in resistance to an intestinal nematode...
  30. ncbi Short report: transient antibody response in Taenia solium infection in field conditions-a major contributor to high seroprevalence
    H H Garcia
    Department of Microbiology, Universidad Peruana Cayetano Heredia, Lima
    Am J Trop Med Hyg 65:31-2. 2001
    ..Transient antibodies may have significant implications for the epidemiology of and immunity to this disease...
  31. ncbi Swine cysticercosis hotspots surrounding Taenia solium tapeworm carriers
    Andres G Lescano
    School of Public Health and Administration and Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru
    Am J Trop Med Hyg 76:376-83. 2007
    ..005). In rural areas, swine cysticercosis occurs in high-risk hotspots around carriers where control interventions could be delivered...
  32. ncbi Evidence for an association between human resistance to Schistosoma mansoni and high anti-larval IgE levels
    P Rihet
    Centre d Immunologie INSERM CNRS de Marseille Luminy, France
    Eur J Immunol 21:2679-86. 1991
    ..Altogether, these observations can be taken as evidence supporting a role of IgE in human resistance to infection by S. mansoni...
  33. pmc Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection
    Fernanda C Cardoso
    Departamento de Bioquímica e Imunologia do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    PLoS Negl Trop Dis 2:e308. 2008
    ..In this study, we investigated murine cellular immune responses to recombinant (r) Sm29 and tested this protein as a vaccine candidate...
  34. ncbi Malaria co-infection in children influences antibody response to schistosome antigens and inflammatory markers associated with morbidity
    F Remoue
    Inserm Unité 547, Institut Pasteur de Lille, 1 rue du Prof Calmette, F 59019 Lille, France
    Trans R Soc Trop Med Hyg 97:361-4. 2003
    ....
  35. ncbi A novel recombinant antigen for immunodiagnosis of human cystic echinococcosis
    Jun Li
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and the University of Queensland, Brisbane, Australia
    J Infect Dis 188:1951-60. 2003
    ..6%. The combined levels of sensitivity and specificity achieved with the rEpC1-GST fusion protein for diagnosis of CE are unprecedented, taking into account the large panel of serum samples that were tested...
  36. ncbi Immunization with plasmid DNA encoding the integral membrane protein, Sm23, elicits a protective immune response against schistosome infection in mice
    P J Skelly
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Vaccine 20:359-69. 2001
    ..001-0.02). Co-administration of plasmids encoding either IL-12 or IL-4 did not significantly enhance this protective effect...
  37. ncbi Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A
    C T Kyngdon
    Veterinary Clinical Centre, The University of Melbourne, Werribee, Victoria, Australia
    Parasite Immunol 28:191-9. 2006
    ....
  38. ncbi Serological responses among individuals in areas where both schistosomiasis and malaria are endemic: cross-reactivity between Schistosoma mansoni and Plasmodium falciparum
    Cynthia W A Naus
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Infect Dis 187:1272-82. 2003
    ..The immunological and biological implications of this observation require further exploration...
  39. ncbi Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics
    Philip J Cooper
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 111:995-1000. 2003
    ..Childhood infections might protect against the expression of atopy. Geohelminths are among the most prevalent infections of childhood and might contribute to the low prevalence of allergic disease reported from rural areas of the tropics...
  40. ncbi Immune rejection of Trichostrongylus colubriformis in sheep; a possible role for intestinal mucus antibody against an L3-specific surface antigen
    G B L Harrison
    AgResearch Ltd, Wallaceville Animal Research Centre, Ward St, Upper Hutt, New
    Parasite Immunol 25:45-53. 2003
    ..The 35 kDa T. colubriformis larval antigen and related molecules in other nematodes are potential novel targets for stimulating host-protective immunity against nematode infections...
  41. pmc Identification of a novel antigen of Schistosoma mansoni shared with Plasmodium falciparum and evaluation of different cross-reactive antibody subclasses induced by human schistosomiasis and malaria
    Christine Pierrot
    Unité INSERM 547, IFR 17, Institut Pasteur de Lille, 1 rue du Prof Calmette, 59019 Lille, France
    Infect Immun 74:3347-54. 2006
    ..In addition, the levels of anti-SmLRR IgG4, but not the levels of IgG3, correlated positively with the intensity of S. mansoni infection...
  42. ncbi Improved serodiagnosis of alveolar echinococcosis of humans using an in vitro-produced Echinococcus multilocularis antigen
    N Muller
    Institute of Parasitology, University of Berne, Berne, Switzerland
    Parasitology 134:879-88. 2007
    ..multilocularis-specific antibody reactivities not detectable by ELISA...
  43. ncbi Echinococcosis: serological detection of patients and molecular identification of parasites
    Akira Ito
    Asahikawa Medical College, Department of Parasitology, Midorigaoka, Higashi, Asahikawa, Hokkaido, Japan
    Future Microbiol 2:439-49. 2007
    ..Both the serological detection of the disease and molecular phylogeny will be discussed in perspective...
  44. ncbi Immunity induced by the radiation-attenuated schistosome vaccine
    J P Hewitson
    Department of Biology, The University of York, York YO10 5YW, UK
    Parasite Immunol 27:271-80. 2005
    ..In this respect, the RA vaccine elicits a multifaceted immune response, from which we can derive valuable insights relevant to the future design of novel delivery systems and adjuvants for recombinant and subunit vaccines...
  45. ncbi Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis
    Simon Babayan
    Parasitologie Comparée et Modèles expérimentaux associé à INSERM U567 et Ecole Pratique des Hautes Etudes, Museum national d histoire naturelle, 61 rue Buffon, 75213, Paris Cedex 05, France
    Med Microbiol Immunol 194:151-62. 2005
    ..This suggests that the very early events determine subsequent immune response and infection outcome rather than competitive interactions between the worms...
  46. pmc Improved immunodiagnosis of cystic hydatid disease by using a synthetic peptide with higher diagnostic value than that of its parent protein, Echinococcus granulosus antigen B
    G Gonzalez-Sapienza
    Catedra de Immunologia, Facultad de Quimica, Universidad de la Republica, Montevideo, Uruguay
    J Clin Microbiol 38:3979-83. 2000
    ..In view of its high diagnostic value and its nature as a well-defined reproducible antigen, p176 could conveniently be used as a reference standard antigen in the diagnosis of hydatid disease...
  47. ncbi Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?
    M Eberl
    Department of Biology, University of York, York, United Kingdom
    J Infect Dis 183:1238-47. 2001
    ..Their occurrence in humans might explain the long time required for antischistosome immunity to build up after infection...
  48. ncbi Impairment of the Schistosoma mansoni-specific immune responses elicited by treatment with praziquantel in Ugandans with HIV-1 coinfection
    Sarah Joseph
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Infect Dis 190:613-8. 2004
    ..These deficiencies in immune responses may account for the previously reported increased susceptibility to infection and reinfection with S. mansoni in individuals coinfected with HIV-1...
  49. ncbi Recombinant paramyosin (rec-Sj-97) tested for immunogenicity and vaccine efficacy against Schistosoma japonicum in mice and water buffaloes
    D P McManus
    Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, 300 Herston Road, Queensland 4029, Brisbane, Australia
    Vaccine 20:870-8. 2001
    ....
  50. ncbi Vaccine efficacy of recombinant cathepsin D aspartic protease from Schistosoma japonicum
    C K Verity
    Division of Infectious Diseases and Immunology and The CRC for Vaccine Technology, The Queensland Institute of Medical Research, Royal Brisbane Hospital, Queensland, Australia
    Parasite Immunol 23:153-62. 2001
    ..These results suggest that antibodies may not play a key role in the protective effect elicited, and that protection may be due to a combination of humoral and cell-mediated responses..
  51. ncbi Dog echinococcosis in northern Spain: comparison of coproantigen and serum antibody assays with coprological exam
    Aitziber Benito
    Department of Immunology, Microbiology and Parasitology, Faculty of Pharmacy, University of the Basque Country, P O Box 450, 01080 Vitoria, Spain
    Vet Parasitol 142:102-11. 2006
    ..granulosus between old and young dogs. The obtained results highlight the importance of initiating a control program based on regular treatment of the sheep-dogs with praziquantel in the province of Alava...
  52. ncbi In vitro cellular and humoral responses to Schistosoma mansoni vaccine candidate antigens
    Maged Al-Sherbiny
    Department of Zoology, Faculty of Science, Cairo University Egyptian Reference Diagnostic Center ERDC VACSERA, 7 Okba Ibn Nafei F 37, Dokki, Giza, 12311, Cairo, Egypt
    Acta Trop 88:117-30. 2003
    ..The insights gained from this approach should be useful for antigen selection and ultimately for vaccine formulation prior to Phase I/II trials in humans...
  53. ncbi Toxocara canis meningomyelitis
    Valérie Dauriac-Le Masson
    J Neurol 252:1267-8. 2005
  54. ncbi Cystic echinococcosis: progress and limits in epidemiology and immunodiagnosis
    A Siracusano
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Roma, Italy
    Parassitologia 48:65-6. 2006
    ..Furthermore, because serological tests can give only a limited support to clinical findings there is a clear need for new advances in immunodiagnosis of E. granulosus infection...
  55. pmc Immuno-epidemiology of human Schistosoma haematobium infection: preferential IgG3 antibody responsiveness to a recombinant antigen dependent on age and parasite burden
    Francisca Mutapi
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Rd, Edinburgh, EH9 3J, UK
    BMC Infect Dis 6:96. 2006
    ..The aim of this study was to identify a single antigen from adult Schistosoma haematobium worms and subsequently use this antigen to study the development of schistosome-acquired immunity in a human population...
  56. ncbi A DNA-prime/protein-boost vaccination regimen enhances Th2 immune responses but not protection following Schistosoma mansoni infection
    Akram A Da'Dara
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Parasite Immunol 25:429-37. 2003
    ..In our study, this was likely due to the use of the Th2-driving adjuvant alum, and future studies are planned where we will compare the protective efficacy of rSm23 administered with Th1-type adjuvants...
  57. ncbi Infectivity and pathogenicity of 14-month-cultured embryonated eggs of Toxocara canis in mice
    Chia Kwung Fan
    Division of Parasitology, Institute of Microbiology, College of Medicine, National Taiwan University, No 1 Jen Ai Road, Section 1, Taipei 100, Taiwan, ROC
    Vet Parasitol 113:145-55. 2003
    ..Altogether, not only were the infectivity and pathogenicity of the 14-month-cultured T. canis embryonated eggs retained, the hatched larvae were also capable of eliciting some special pathological changes in the murine host...
  58. pmc Possible approach for serodiagnosis of ascariasis by evaluation of immunoglobulin G4 response using Ascaris lumbricoides somatic antigen
    T Bhattacharyya
    Department of Biological Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Calcutta 700 032, India
    J Clin Microbiol 39:2991-4. 2001
    ....
  59. ncbi Exposure, infection and immune responses to Schistosoma haematobium in young children
    M E Woolhouse
    Centre for Veterinary Tropical Medicine, University of Edinburgh, Scotland
    Parasitology 120:37-44. 2000
    ..This suggests that there may be substantial attrition of invading cercaria even in naïve individuals...
  60. ncbi A critical role for IL-13 in resistance to intestinal nematode infection
    A J Bancroft
    School of Biological Science, University of Manchester, United Kingdom
    J Immunol 160:3453-61. 1998
    ..The IL-13 KO mouse had a separate phenotype to that of the IL-4 KO mouse, suggesting that both IL-4 and IL-13 play important yet different roles in mediating immunity to intestinal helminths...
  61. ncbi Associations between anti-Schistosoma mansoni and anti-Plasmodium falciparum antibody responses and hepatosplenomegaly, in Kenyan schoolchildren
    Joseph K Mwatha
    Kenya Medical Research Institute, Kenyan Ministry of Health, Nairobi, Kenya
    J Infect Dis 187:1337-41. 2003
    ..falciparum antibodies, compared with nonhepatosplenic children, a finding that strongly suggests that some experience of P. falciparum influenced the development of hepatosplenomegaly in these S. mansoni-infected children...
  62. ncbi The influence of sex and age on antibody isotype responses to Schistosoma mansoni and Schistosoma japonicum in human populations in Kenya and the Philippines
    M Webster
    Department of Pathology, University of Cambridge
    Parasitology 114:383-93. 1997
    ..Only those individuals with relatively high IgE titres specifically reactive with S. mansoni or S. japonicum AW had detectable IgE against Sj22 or Sm22...
  63. pmc Laboratory diagnosis of human neurocysticercosis: double-blind comparison of enzyme-linked immunosorbent assay and electroimmunotransfer blot assay
    J V Proaño-Narvaez
    Hospital de Especialidades del Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social Mexico City, Mexico City, Mexico
    J Clin Microbiol 40:2115-8. 2002
    ..The immunodominant bands were found to be the same as those previously reported, i.e., GP-39 to -42, GP-24, and GP-13. Based on these results, we suggest the use of the EITB assay in routine diagnosis of cysticercosis for clinical cases...
  64. ncbi Saposin-like proteins are expressed in the gastrodermis of Schistosoma mansoni and are immunogenic in natural infections
    Tegan A Don
    Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, 300 Herston Rd, Brisbane 4006, Queensland, Australia
    Int J Infect Dis 12:e39-47. 2008
    ..We now provide the first report of SAPLIPs from schistosomes and explore their role in host-parasite interactions...
  65. ncbi Echinococcus multilocularis metacestode extract triggers human basophils to release interleukin-4
    E Aumüller
    Division of Cellular Allergology, Research Centre Borstel, Borstel, Germany
    Parasite Immunol 26:387-95. 2004
    ..Since analogous properties have been demonstrated earlier for IPSE, we think that S. mansoni and E. multilocularis may induce a Th2 response in their hosts via a related mechanism, namely, by the induction of IL-4 release from basophils...
  66. ncbi Immunodiagnosis of human neurocysticercosis using a synthetic peptide selected by phage-display
    R C R Hell
    Departamento de Bioquímica Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte MG, Brazil
    Clin Immunol 131:129-38. 2009
    ..Our results show that a peptide-based immunodiagnostic of neurocisticercosis can be envisioned...
  67. pmc Onchocerca volvulus glycolytic enzyme fructose-1,6-bisphosphate aldolase as a target for a protective immune response in humans
    James S McCarthy
    University of Western Australia, Department of Medicine, Fremantle Hospital, Fremantle, Western Australia, Australia
    Infect Immun 70:851-8. 2002
    ..50% was seen. This observation provides support for the further study of this parasite enzyme as a vaccine candidate in larger animal models...
  68. ncbi Early post-treatment immunoglobulin profile in human schistosomiasis
    Amany A Abd El-Aal
    Department of Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt
    J Egypt Soc Parasitol 35:167-80. 2005
    ....
  69. ncbi Toxocara seroprevalence in children from a subtropical city in Argentina
    J M Alonso
    Instituto de Medicina Regional, Universidad Nacional del Nordeste, Resistencia, Argentina
    Rev Inst Med Trop Sao Paulo 42:235-7. 2000
    ..An increased risk of infection was observed in age groups 5-6 and 7-8 for boys, and in age groups 3-4 and 5-6 for girls...
  70. ncbi The schistosoma-specific antibody response after treatment in non-immune travellers
    Liv Marie Duus
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, DK 8200 Aarhus N, Denmark
    Scand J Infect Dis 41:285-90. 2009
    ..Treatment failure in 15% of non-immune patients indicates that studies are needed to define the correct dose of praziquantel in those individuals or to evaluate if resistance to praziquantel is a growing problem...
  71. ncbi Comparison of the sensitive screening kit with two ELISA sets for detection of anti-Toxocara antibodies
    P Dubinsky
    Parasitological Institute of the Slovak Academy of Sciences, Kosice, Slovak Republic
    Southeast Asian J Trop Med Public Health 31:394-8. 2000
    ..3%; ELISA NOVUM and ToxocaraCHEK 96.7% and ELISA PU and ToxocaraCHEK 86.7%. This comparison indicates the suitability of ToxocaraCHEK set for screening for its simplicity and rapidity in detecting anti-Toxocara antibodies...
  72. ncbi Defining a schistosomiasis vaccination strategy - is it really Th1 versus Th2?
    T A Wynn
    Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Parasitol Today 16:497-501. 2000
    ..However, recent data from cytokine-knockout mice suggest that choosing between these opposing pathways may be less important than previously hypothesized, as discussed here by Thomas Wynn and Karl Hoffmann...
  73. ncbi Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs
    Ricardo T Fujiwara
    Department of Microbiology and Tropical Medicine, The George Washington University, 2300 Eye Street, Ross Hall Room 727, Medical Center, Washington, DC 20037, USA
    Vaccine 24:501-9. 2006
    ....
  74. ncbi Parasitology and immunology of mice vaccinated with irradiated Litomosoides sigmodontis larvae
    L Le Goff
    Institut de Systématique, CNRS FRS 1541, Biologie Parasitaire, Museum national d histoire naturelle, Paris, France
    Parasitology 120:271-80. 2000
    ..In both vaccinated challenged and challenged only groups, the in vitro splenocyte proliferative capacity was reduced in microfilaraemic mice...
  75. ncbi Schistosomiasis and malaria: another piece of the crossreactivity puzzle
    Helena Helmby
    Immunology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trends Parasitol 23:88-90. 2007
    ..One such shared antigen (SmLRR) has now been cloned and has, therefore, opened up an intriguing and exciting field of research for immunologists and parasitologists...
  76. ncbi Investigation of recombinant Schistosoma japonicum paramyosin fragments for immunogenicity and vaccine efficacy in mice
    D M Zhang
    Department of Etiologic Biology, Second Military Medical University, Shanghai, China
    Parasite Immunol 28:77-84. 2006
    ..There was no apparent correlation between the antibody titres generated and protective efficacy, as all fragments produced effective but similar levels of protection...
  77. ncbi Increased human IgE induced by killing Schistosoma mansoni in vivo is associated with pretreatment Th2 cytokine responsiveness to worm antigens
    Klaudia Walter
    Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 177:5490-8. 2006
    ....
  78. ncbi Antibody responses of patients with cystic hydatid disease to recombinant myophilin of Echinococcus granulosus
    R M Martin
    University of Melbourne, Department of Veterinary Science, Victoria, Australia
    Acta Trop 61:307-14. 1996
    ....
  79. ncbi Screening for cystic echinococcosis in an endemic region of Peru using portable ultrasonography and the enzyme-linked immunoelectrotransfer blot (EITB) assay
    Pedro L Moro
    National Immunization Program, Centers for Disease Control and Prevention, 1600 Clifton Rd, 61, Atlanta, GA, USA
    Parasitol Res 96:242-6. 2005
    ..9% and 2.6%, respectively. Fifty-three percent of subjects with CE were EITB positive. Portable ultrasound was well received by the community, augmented CE detection and allowed a faster estimate of human infection than the EITB assay...
  80. ncbi Effect of vaccination with a recombinant fusion protein encoding an astacinlike metalloprotease (MTP-1) secreted by host-stimulated Ancylostoma caninum third-stage infective larvae
    Peter J Hotez
    Department of Microbiology and Tropical Medicine and Sabin Vaccine Institute, The George Washington University Medical Center, 2300 Eye Street NW, Washington, DC 20037, USA
    J Parasitol 89:853-5. 2003
    ..89; P = 0.04), suggesting that this molecule offers promise as a recombinant vaccine...
  81. ncbi The Secreted Larval Acidic Proteins (SLAPs) of Onchocerca spp. are encoded by orthologues of the alt gene family of Brugia malayi and have host protective potential
    Yang Wu
    Division of Molecular Biology and Immunology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Mol Biochem Parasitol 134:213-24. 2004
    ..They may also offer promise as components of a future sub-unit vaccine should the means to enhance protection be achieved...
  82. ncbi CD4+-dependent immunity to Onchocerca volvulus third-stage larvae in humans and the mouse vaccination model: common ground and distinctions
    Sara Lustigman
    Laboratory of Molecular Parasitology, Lindsley F Kimball Research Institute, New York Blood Center, 310 E 67th Street, New York, NY 10021, USA
    Int J Parasitol 33:1161-71. 2003
    ..volvulus L3 protective immunity in both humans and mice could be applicable to the development of vaccines against other nematode infections...
  83. ncbi Onchocerca ochengi acquisition in zebu Gudali cattle exposed to natural transmission: parasite population dynamics and IgG antibody subclass responses to Ov10/Ov11 recombinant antigens
    M D Achukwi
    Department of Immunology, Strathclyde University, 31 Taylor Street, Glasgow G4 ONR, UK
    Vet Parasitol 122:35-49. 2004
    ..ochengi parasites in zebu cattle, apart from being season, sex (gender) and host age associated, may also suggest a density-dependent regulation of parasite establishment in a proportion of the exposed population...
  84. pmc A seroepidemiologic survey for human sparganosis in Gangweon-do
    Kyu Jae Lee
    Department of Parasitology, Wonju college of medicine and IFBB, Yonsei University, Wonju 220 701, Korea
    Korean J Parasitol 40:177-80. 2002
    ..Two positive cases had a past history of sparganosis. Two positive cases showed current symptoms of sparganosis. The data revealed that ELISA would be useful to find infected cases among normal inhabitants at sparganosis-endemic areas...
  85. pmc Isolation of antibodies specific to a single conformation-dependant antigenic determinant on the EG95 hydatid vaccine
    A J Read
    The University of Melbourne, Veterinary Clinical Centre, 250 Princes Highway, Werribee, Victoria 3030, Australia
    Vaccine 27:1024-31. 2009
    ..Peptide E100 may represent the basis for a quality control assay for EG95 production, and has the potential to become a component of a synthetic peptide-based vaccine against E. granulosus...
  86. ncbi Intestinal nematode parasites, cytokines and effector mechanisms
    K J Else
    School of Biological Sciences, University of Manchester, U K
    Int J Parasitol 28:1145-58. 1998
    ..Thus, our understanding of both the induction and effector phases remains incomplete and will remain an intense area of interest in the coming years...
  87. ncbi Expression and characterization of Ov-47, a dominant antigen of Onchocerca volvulus
    Stephen M Ghogomu
    Faculty of Science, University of Buea, Buea, Cameroon
    Exp Parasitol 100:143-9. 2002
    ..IgG1, IgG3, and IgG4 responses did not show any age dependency. This study clearly shows that Ov-47 is a dominant antigen of O. volvulus adult worms with an important role in the host-parasite-interplay...
  88. ncbi Vaccination of calves against Ostertagia ostertagi with cysteine proteinase enriched protein fractions
    P Geldhof
    Department of Parasitology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B9820 Merelbeke, Belgium
    Parasite Immunol 24:263-70. 2002
    ..However, these correlations were quite weak and did not appear to be isotype-specific...
  89. ncbi Schistosoma mansoni-infected mice produce antibodies that cross-react with plant, insect, and mammalian glycoproteins and recognize the truncated biantennaryN-glycan Man3GlcNAc2-R
    Alexandra van Remoortere
    Department of Molecular Cell Biology, Glycoimmunology Group, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Glycobiology 13:217-25. 2003
    ..Nevertheless, no elevated antibody levels against this glycan epitope could be detected in sera of individuals infected with Schistosoma mansoni...
  90. ncbi Seroincidence of porcine T. solium infection in the Peruvian highlands
    H H Garcia
    Department of Microbiology, Universidad Peruana Cayetano Heredia, Av Honorio Delgado 430, San Martin de Porras, Lima, Peru
    Prev Vet Med 57:227-36. 2003
    ..A proportion of seropositive animals became seronegative at the end of each period (23 and 15%). Incidence varied by the village, and the exposure period, and was higher in males than females (but did not differ by age)...
  91. ncbi [Fasciola hepatica seroprevalence in the Elaziğ region]
    Mustafa Kaplan
    Firat Universitesi Tip Fakultesi, Parazitoloji Anabilim Dali, Elazig
    Mikrobiyol Bul 36:337-42. 2002
    ..76% and 2.8%). F. hepatica IgG positive subjects were then evaluated for the parameters of age, educational and socioeconomical status, and it was found that there were no statistically significant differences...
  92. ncbi Studies on the protective immunity of Schistosoma japonicum bivalent DNA vaccine encoding Sj23 and Sj14
    Hu Yuan
    Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Exp Parasitol 115:379-86. 2007
    ..There was no significant impact on immunity protection exerted by the four factors including dosage, inoculated times, inoculated routes and challenge time after the last immunization in three levels (p>0.05)...
  93. ncbi Immunoassays as an auxiliary tool for the serodiagnosis of Schistosoma mansoni infection in individuals with low intensity of egg elimination
    Margareth M L Gonçalves
    Departamento de Imunologia, Instituto de Microbiologia Professor Paulo de Góes CCS, Universidade Federal do Rio de Janeiro, 21941590 Rio de Janeiro, Brazil
    Acta Trop 100:24-30. 2006
    ..Our findings suggest that a screening method that combines antibody isotype detection and repeated parasitological stool examinations could increase the chances of detecting S. mansoni-infected patients...
  94. ncbi Application of Toxocara canis excretory-secretory antigens and IgG subclass antibodies (IgG1-4) in serodiagnostic assays of human toxocariasis
    Dorn Watthanakulpanich
    School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK
    Acta Trop 106:90-5. 2008
    ..Thus, of the IgG subclass antibodies, IgG2 appeared best and employing this subclass can improve the serodiagnosis of human toxocariasis since it recognises carbohydrate epitopes of TES antigens...
  95. ncbi Serodiagnosis of Schistosoma mansoni infections in an endemic area of Burkina Faso: performance of several immunological tests with different parasite antigens
    Hermann Sorgho
    Institut de recherche en sciences de la sante, Bobo Dioulasso, Burkina Faso
    Acta Trop 93:169-80. 2005
    ..For the purpose of further surveys in Burkina Faso or other resource-poor settings, we suggest IHA as an accurate diagnostic test and propose to further improve its performance by including egg rather than worm antigens...
  96. ncbi Strongyloides venezuelensis: the antigenic identity of eight strains for the immunodiagnosis of human strongyloidiasis
    Eleuza Rodrigues Machado
    Departamento de Parasitologia, Instituto de Biologia, Universidade Estadual de Campinas, Cidade Universitária Zeferino Vaz s n CEP 13083 970, Caixa Postal 6109, Campinas, SP, Brazil
    Exp Parasitol 119:7-14. 2008
    ..stercoralis revealed antigens from different strains of S. venezuelensis, indicating antigenic identity for possible use in the synthesis of recombinant antigen that could be useful in immunodiagnosis and vaccine against this parasite...
  97. ncbi Oral administration of a Bacillus subtilis spore-based vaccine expressing Clonorchis sinensis tegumental protein 22.3 kDa confers protection against Clonorchis sinensis
    Zhenwen Zhou
    Guangzhou Women and Children s Medical Center, 318 Renminzhong road, Guangzhou 510120, People s Republic of China
    Vaccine 26:1817-25. 2008
    ..05) in rats challenged with C. sinensis metacercariae. This report shows that C. sinensis TP22.3 expressed on B. subtilis spores was immunogenic and oral administration of TP22.3 spore can provide protection against C. sinensis...
  98. ncbi [Enhancement of laboratory diagnosis specificity in human toxocariasis]
    H Zarnowska-Prymek
    , 01-201 Warszawa, ul. Wolska 37
    Wiad Parazytol 47:489-96. 2001
    ..Comparative study with different ELISA tests indicated that use of low molecular weight antigens increase specificity of reaction...
  99. ncbi IgG1, IgG4, and IgE antibody responses in human strongyloidiasis by ELISA using Strongyloides ratti saline extract as heterologous antigen
    Rosângela M Rodrigues
    Departamento de Imunologia, Microbiologia e Parasitologia, Instituto de Ciencias Biomedicas, Universidade Federal de Uberlandia, Avenida Pará 1720, CEP 38400 902, Uberlandia, Minas Gerais, Brazil
    Parasitol Res 101:1209-14. 2007
    ..using the S. ratti antigen showed to be an additional tool for improving the serodiagnosis of human strongyloidiasis...
  100. ncbi [The usefulness of ELISA test for early serological detection of Trichinella spp. infection in pigs]
    Justyna Bien
    Instytucie Parazytologii im W Stefańskiego PAN w Warszawie
    Wiad Parazytol 53:149-51. 2007
    ..Simultaneous use of both methods: digestion and ELISA for the diagnosis of Trichinella in naturally infected pigs and wild boars may increase the chances of eliminating meat infected with T. spiralis larvae...
  101. ncbi Evaluation of Fas2-ELISA for the serological detection of Fasciola hepatica infection in humans
    Jose R Espinoza
    Unit of Molecular Biotechnology, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru
    Am J Trop Med Hyg 76:977-82. 2007
    ..Results show that Fas2-ELISA is a highly sensitive immunodiagnostic test for the detection of F. hepatica infection in children living in human fascioliasis endemic areas...

Research Grants18

  1. Mucosal Immune Responses in Hookworm Infection
    Richard Bungiro; Fiscal Year: 2006
    ..These studies are expected to further our understanding of host-parasite immunological interaction and advance hookworm vaccine research through the development of novel immunization techniques. ..
  2. Schistosome Calpain as a Vaccine Candidates
    Afzal Siddiqui; Fiscal Year: 2002
    ..Of greater importance, these studies should provide new insight into immune mechanisms which can damage worm parasites and establish a model by which to subsequently study the effector mechanisms. ..
  3. A Helminth-Derived Immune Potentiator for Biodefense
    Sara Lustigman; Fiscal Year: 2006
    ..abstract_text> ..
  4. Microsphere based Tolerogenic antigen presentation system
    Chenthamarakshan Vasu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. Ecosystem disturbance and multiscale transmission of a zoonotic wildlife pathogen
    Philip Craig; Fiscal Year: 2007
    ....
  6. IMMUNITY TO PARASITIC INFECTION
    Judith Appleton; Fiscal Year: 2008
    ..The work we propose will elucidate a potent mechanism of intestinal immunity and will improve our ability to develop novel vaccines for intestinal pathogens. ..
  7. Optional Influenza Vaccine And Population Adherence
    Alison Galvani; Fiscal Year: 2009
    ....
  8. TRICHINELLOSIS AND REGULATION OF HOST GENE EXPRESSION
    Douglas Jasmer; Fiscal Year: 2001
    ..Understanding these mechanisms may also contribute unique insight on mechanisms of muscle differentiation and cell cycle regulation in mammalian cells. ..
  9. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2005
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  10. Generation of antigen specific regulatory T cells
    Chenthamarakshan Vasu; Fiscal Year: 2005
    ..In aim-l, we will test the efficacy of BiAb in inducing regulatory T cells in vivo and in vitro. In aim-2, we will test the ability of these regulatory T cells in down modulating EAT and CIA. ..
  11. International Conference on Trichinellosis
    Judith Appleton; Fiscal Year: 2004
    ..abstract_text> ..
  12. PREGNANCY INDUCED REACTIVATION OF ARRESTED HOOKWORMS
    Prema Arasu; Fiscal Year: 2003
    ..These studies will provide important results for the development of therapeutic strategies to eradicate latent parasitic infections. ..
  13. Hepatitis Virus, Alcohol Exposure and Oxidative Stress
    Manal Hassan; Fiscal Year: 2002
    ..Serum Se, GPx activity, lipid peroxides and oxidative DNA damage will be measured in relation to HCV and alcohol intake history. ..
  14. HOOKWORM LARVAL INFECTIVITY AND DEVELOPMENT
    Peter Hotez; Fiscal Year: 2002
    ..The pharmacologic manipulation of parasite-derived protein kinases may offer a new approach to chemotherapy by taking larvae out of arrest. ..
  15. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2001
    ..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application. ..
  16. IMMUNOREGULATION IN HUMAN STRONGYLOIDIASIS
    Martin Montes; Fiscal Year: 2010
    ..Studies of immunoregulation in strongyloidiasis may also lead to insights needed for addressing the burden of intestinal nematodes, which affect billions of people. ..