fungal antibodies

Summary

Summary: Immunoglobulins induced by substances elaborated by FUNGI that have an antigenic activity.

Top Publications

  1. ncbi Reactivity of antibodies from patients with acute and chronic paracoccidioidomycosis to a high molecular mass antigen from Paracoccidioides brasiliensis
    A S Marquez
    Biological and Health Center, UNOPAR and Microbiology Postgraduation Program, UEL, Londrina, Brazil
    J Clin Lab Anal 19:199-204. 2005
  2. pmc Immunoglobulin G responses to a panel of Candida albicans antigens as accurate and early markers for the presence of systemic candidiasis
    Cornelius J Clancy
    Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    J Clin Microbiol 46:1647-54. 2008
  3. ncbi Decoding serological response to Candida cell wall immunome into novel diagnostic, prognostic, and therapeutic candidates for systemic candidiasis by proteomic and bioinformatic analyses
    Aida Pitarch
    Department of Microbiology II, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
    Mol Cell Proteomics 5:79-96. 2006
  4. pmc Expression of antibodies directed to Paracoccidioides brasiliensis glycosphingolipids during the course of paracoccidioidomycosis treatment
    Silvio Bertini
    Department of Biochemistry, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Botucatu, 862, Sao Paulo, SP 04023 900, Brazil
    Clin Vaccine Immunol 14:150-6. 2007
  5. ncbi Diagnostic role of anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic antibodies in patients with inflammatory bowel disease
    Byeong Gwan Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Dis Colon Rectum 45:1062-9. 2002
  6. ncbi IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans
    Uwe Muller
    Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    J Immunol 179:5367-77. 2007
  7. pmc Current status of nonculture methods for diagnosis of invasive fungal infections
    Siew Fah Yeo
    Infectious Disease Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Microbiol Rev 15:465-84. 2002
  8. pmc Diagnosis of invasive candidiasis by enzyme-linked immunosorbent assay using the N-terminal fragment of Candida albicans hyphal wall protein 1
    Ana Laín
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Bilbao, Vizcaya, Spain
    BMC Microbiol 7:35. 2007
  9. ncbi Production of hybrid phage displaying secreted aspartyl proteinase epitope of Candida albicans and its application for the diagnosis of disseminated candidiasis
    Qiong Yang
    Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University, Changchun City, Jilin Province, People s Republic of China
    Mycoses 50:165-71. 2007
  10. pmc Evaluation of a novel enzyme-linked immunosorbent assay to detect immunoglobulin G antibody to enolase for serodiagnosis of invasive candidiasis
    Ana Laín
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Apartado 699, E 48080 Bilbao, Vizcaya, Spain
    Clin Vaccine Immunol 14:318-9. 2007

Research Grants

  1. Monoclonal antibodies to inhibit Aspergillus germination
    MARTA L FELDMESSER; Fiscal Year: 2010
  2. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2006
  3. Mining slime mold for susceptibility genes to fungi
    Arturo Casadevall; Fiscal Year: 2005
  4. Aspergillosis: Engineering Antibody for Diagnosis
    Marta Feldmesser; Fiscal Year: 2006
  5. MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANS
    JOSHUA NOSANCHUK; Fiscal Year: 2002
  6. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
  7. Monoclonal antibodies for invasive aspergillosis
    Marta Feldmesser; Fiscal Year: 2003
  8. CANDIDA ALBICANS SURFACE ANTIGENS
    Jim Cutler; Fiscal Year: 2006
  9. HUMAN ANTIBODIES TO CRYPTOCOCCUS NEOFORMANS
    Liise Anne Pirofski; Fiscal Year: 2009
  10. Parental Expression of Immune Responses In Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008

Detail Information

Publications184 found, 100 shown here

  1. ncbi Reactivity of antibodies from patients with acute and chronic paracoccidioidomycosis to a high molecular mass antigen from Paracoccidioides brasiliensis
    A S Marquez
    Biological and Health Center, UNOPAR and Microbiology Postgraduation Program, UEL, Londrina, Brazil
    J Clin Lab Anal 19:199-204. 2005
    ..brasiliensis h-MM antigen. This study reveals a new characteristic to differentiate between the acute and chronic forms of PCM, by demonstrating a higher level of seric IgG to h-MM antigen in chronic compared to acute PCM patients...
  2. pmc Immunoglobulin G responses to a panel of Candida albicans antigens as accurate and early markers for the presence of systemic candidiasis
    Cornelius J Clancy
    Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    J Clin Microbiol 46:1647-54. 2008
    ..Taken together, our findings suggest that IgG responses against a panel of candidal antigens might represent an accurate and early marker of systemic candidiasis, a hypothesis that should be tested in future trials...
  3. ncbi Decoding serological response to Candida cell wall immunome into novel diagnostic, prognostic, and therapeutic candidates for systemic candidiasis by proteomic and bioinformatic analyses
    Aida Pitarch
    Department of Microbiology II, Faculty of Pharmacy, Complutense University of Madrid, 28040 Madrid, Spain
    Mol Cell Proteomics 5:79-96. 2006
    ..Furthermore serum anti-wall enolase antibodies are a new prognostic indicator for SC and confer protection against it. Bgl2p and wall-associated enolase could be valuable candidates for future vaccine development...
  4. pmc Expression of antibodies directed to Paracoccidioides brasiliensis glycosphingolipids during the course of paracoccidioidomycosis treatment
    Silvio Bertini
    Department of Biochemistry, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Rua Botucatu, 862, Sao Paulo, SP 04023 900, Brazil
    Clin Vaccine Immunol 14:150-6. 2007
    ..The Pb-1 antigen, an acidic GSL with terminal Galf residue, has potential application as an elicitor of the host immune response in patients with PCM...
  5. ncbi Diagnostic role of anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic antibodies in patients with inflammatory bowel disease
    Byeong Gwan Kim
    Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Chongno Gu, Seoul, Korea
    Dis Colon Rectum 45:1062-9. 2002
    ....
  6. ncbi IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans
    Uwe Muller
    Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    J Immunol 179:5367-77. 2007
    ..This indicates that IL-13 contributes to fatal allergic inflammation during C. neoformans infection...
  7. pmc Current status of nonculture methods for diagnosis of invasive fungal infections
    Siew Fah Yeo
    Infectious Disease Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Microbiol Rev 15:465-84. 2002
    ..This work reviews the current status and recent developments as well as problems in the design of nonculture diagnostic methods for invasive fungal infections...
  8. pmc Diagnosis of invasive candidiasis by enzyme-linked immunosorbent assay using the N-terminal fragment of Candida albicans hyphal wall protein 1
    Ana Laín
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Bilbao, Vizcaya, Spain
    BMC Microbiol 7:35. 2007
    ..In the last decade, much effort has been made to develop reliable tests for rapid diagnosis of invasive candidiasis, but none of them have found widespread clinical use...
  9. ncbi Production of hybrid phage displaying secreted aspartyl proteinase epitope of Candida albicans and its application for the diagnosis of disseminated candidiasis
    Qiong Yang
    Institute of Genetics and Cytology, School of Life Sciences, Northeast Normal University, Changchun City, Jilin Province, People s Republic of China
    Mycoses 50:165-71. 2007
    ..These data indicate this phage-displayed epitope as an effective and less expensive reagent would be a valuable probe for the detection of specific Sap antibody in the sera of patients and mice with systemic C. albicans infection...
  10. pmc Evaluation of a novel enzyme-linked immunosorbent assay to detect immunoglobulin G antibody to enolase for serodiagnosis of invasive candidiasis
    Ana Laín
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Apartado 699, E 48080 Bilbao, Vizcaya, Spain
    Clin Vaccine Immunol 14:318-9. 2007
    ..The sensitivity, specificity, and positive and negative predictive values of the test for the diagnosis of invasive candidiasis were 81.0, 83.9, 79.1, and 85.5%, respectively...
  11. ncbi Canine paracoccidioidomycosis
    G Ricci
    Department of Pathology, Federal University of Sao Paulo UNIFESP EPM, Sao Paulo, Brazil
    Med Mycol 42:379-83. 2004
    ..This is the first report of PCM disease occurring in a dog, an animal that has been shown to play an important role in the natural history of North American blastomycosis...
  12. pmc Antibodies to a cell surface histone-like protein protect against Histoplasma capsulatum
    Joshua D Nosanchuk
    Department of Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 112:1164-75. 2003
    ....
  13. ncbi The immune response to fungal infections
    Shmuel Shoham
    Section of Infectious Diseases, Washington Hospital Center, Washington, DC, USA
    Br J Haematol 129:569-82. 2005
    ..An understanding of the host response to these organisms is important in decisions regarding use of currently available antifungal therapies and in the design of new therapeutic modalities...
  14. pmc Antibody response to Pneumocystis jirovecii major surface glycoprotein
    Kieran R Daly
    Research Service 151, Veterans Affairs Medical Center, 3200 Vine Street, Cincinnati, OH 45220, USA
    Emerg Infect Dis 12:1231-7. 2006
    ..001). Thus, MsgC shows promise as a serologic reagent and should be tested further in clinical and epidemiologic studies...
  15. pmc Therapeutic efficacy of a conjugate vaccine containing a peptide mimotope of cryptococcal capsular polysaccharide glucuronoxylomannan
    Kausik Datta
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Clin Vaccine Immunol 15:1176-87. 2008
    ..Taken together, our data suggest that a vaccine could hold promise in the setting of chronic cryptococcosis, and that vaccine efficacy could depend on immunomodulation and augmentation of the natural immune response of the host...
  16. pmc Advances in combating fungal diseases: vaccines on the threshold
    Jim E Cutler
    Department of Pediatrics and Microbiology, Louisiana State University Health Sciences, and Research Institute for Children at Children s Hospital, New Orleans, Louisiana, 70118 USA
    Nat Rev Microbiol 5:13-28. 2007
    ....
  17. pmc Interplay between protective and inhibitory antibodies dictates the outcome of experimentally disseminated Candidiasis in recipients of a Candida albicans vaccine
    Carla Bromuro
    Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, Rome, USA
    Infect Immun 70:5462-70. 2002
    ..Our observations may also help explain why subjects with elevated anti-Candida antibody titers, inclusive of anti-MP and anti-GG antibodies, remain nonetheless susceptible to invasive candidiasis...
  18. pmc Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90
    Ruth C Matthews
    Department of Medical Microbiology, University of Manchester, Manchester M13 9WL, United Kingdom
    Antimicrob Agents Chemother 47:2208-16. 2003
    ..albicans (kidney), C. krusei (spleen), C. glabrata (spleen), and C. parapsilosis (liver and spleen). Only by combining Mycograb with AMB was complete resolution of infection achieved for C. albicans, C. krusei, and C. glabrata...
  19. pmc An anti-beta-glucan monoclonal antibody inhibits growth and capsule formation of Cryptococcus neoformans in vitro and exerts therapeutic, anticryptococcal activity in vivo
    Anna Rachini
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Infect Immun 75:5085-94. 2007
    ..Overall, these findings demonstrate that cell wall beta-glucan of encapsulated C. neoformans is accessible to antibodies which can exert remarkable anticryptococcal activities in vitro and in vivo...
  20. ncbi [Evaluation of a new commercial test (Candida albicans IFA IgG) for the serodiagnosis of invasive candidiasis]
    María Dolores Moragues
    Departamento de Enfermería I, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Bilbao, Vizcaya, Espana
    Enferm Infecc Microbiol Clin 22:83-8. 2004
    ....
  21. pmc Enzyme-linked immunosorbent assay and serologic responses to Pneumocystis jiroveci
    Kieran R Daly
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0560, USA
    Emerg Infect Dis 10:848-54. 2004
    ..Thus, this ELISA will be useful in studying serum antibody responses to Pneumocystis in different human populations...
  22. ncbi Fungal vaccines: real progress from real challenges
    Antonio Cassone
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet Infect Dis 8:114-24. 2008
    ..Together with the demonstrated efficacy of various antibodies in passive vaccination approaches, there is growing confidence in the future availability of safe and efficacious immunological tools to combat deadly microbes in a weak host...
  23. ncbi A cryptococcal capsular polysaccharide mimotope prolongs the survival of mice with Cryptococcus neoformans infection
    R Fleuridor
    Departments of. Microbiology and Immunology and Medicine, Division of Infectious Diseases, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 166:1087-96. 2001
    ..neoformans and their efficacy in this study suggests that peptide mimotopes selected by protective Abs deserve further consideration as vaccine candidates for encapsulated pathogens...
  24. ncbi Polysaccharides, mimotopes and vaccines for fungal and encapsulated pathogens
    L A Pirofski
    Divn of Infectious Diseases, Room 709 Forchheimer Bldg, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Trends Microbiol 9:445-51. 2001
    ..neoformans in mice, however, our knowledge of the mechanisms of mimotope-induced protection is incomplete and further work is needed if polysaccharide- or mimotope-based vaccines are to be used to manage C. neoformans infection...
  25. pmc Evaluation of a western blot test in an outbreak of acute pulmonary histoplasmosis
    C V Pizzini
    Laboratorio de Micologia Medica, Hospital Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    Clin Diagn Lab Immunol 6:20-3. 1999
    ..WB test with deglycosylated H and M antigens of histoplasmin provides a rapid, sensitive, and specific test to diagnose acute pulmonary histoplasmosis before precipitins can be detected...
  26. ncbi Protective antifungal yeast killer toxin-like antibodies
    W Magliani
    Sezione di Microbiologia, Dipartimento di Patologia e Medicina di Laboratorio, Universita degli Studi di Parma, Parma, Italy
    Curr Mol Med 5:443-52. 2005
    ....
  27. ncbi Is there a role for antibody testing in the diagnosis of invasive candidiasis?
    Guillermo Quindos
    Departamento de Inmunologia, Microbiologia y Parasitologia, Universidad del Pais Vasco Euskal Herriko Unibertsitatea, Bilbao, Spain
    Rev Iberoam Micol 21:10-4. 2004
    ..Results obtained from a panel of diagnostic tests in association with clinical aspects will likely be the most useful strategy for early diagnosis and therapy...
  28. pmc Coccidioidomycosis: host response and vaccine development
    Rebecca A Cox
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, Texas Research Park, 15355 Lambda Dr, San Antonio, TX 78245 3027, USA
    Clin Microbiol Rev 17:804-39, table of contents. 2004
    ....
  29. pmc Amplification of coccidioidal DNA in clinical specimens by PCR
    Suzanne M Johnson
    Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, Davis, California 95616, USA
    J Clin Microbiol 42:1982-5. 2004
    ..A 239-bp product was visualized when 10 fg of exogenous coccidioidal DNA was subjected to amplification. This product was demonstrated in some human and mouse sera prior to the detection of coccidioidal antibodies...
  30. pmc Intravaginal and intranasal immunizations are equally effective in inducing vaginal antibodies and conferring protection against vaginal candidiasis
    Flavia De Bernardis
    Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, 00161 Rome, Italy
    Infect Immun 70:2725-9. 2002
    ..These data suggest that appropriate fungal antigens and adjuvant can be used to protect against candidal vaginitis, by either route...
  31. pmc Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
    Marcio L Rodrigues
    Instituto de Microbiologia Professor Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941 590, Brazil
    Clin Vaccine Immunol 14:1372-6. 2007
    ..neoformans, revealing a potential therapeutic strategy to control cryptococcosis...
  32. ncbi Immunocompetent hosts as a reservoir of pneumocystis organisms: histological and rt-PCR data demonstrate active replication
    M Chabé
    Ecology of Parasitism, Lille Pasteur Institute, 1 rue du Prof Calmette BP245, 59019, Lille, France
    Eur J Clin Microbiol Infect Dis 23:89-97. 2004
    ..The results showed Pneumocystis organisms were able to replicate in the lungs of immunocompetent hosts, which indicates these hosts are a reservoir for Pneumocystis spp...
  33. ncbi Defining criteria for anti-mannan antibodies to protect against candidiasis
    J E Cutler
    The Research Institute for Children and LSUHSC, Dept of Pediatrics and Dept of Microbiology, Children s Hospital, New Orleans, LA 70118, USA
    Curr Mol Med 5:383-92. 2005
    ....
  34. ncbi Long-term colonization with Pneumocystis jirovecii in hospital staffs: a challenge to prevent nosocomial pneumocystosis
    Isabelle Durand-Joly
    EA 3609 Pasteur Institute of Lille, Lille, France
    J Eukaryot Microbiol 50:614-5. 2003
  35. ncbi Early diagnosis of invasive candidiasis with mannan antigenemia and antimannan antibodies
    Maura Prella
    Infectious Diseases Service, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Diagn Microbiol Infect Dis 51:95-101. 2005
    ..001). Candidiasis was diagnosed before neutrophil recovery in 78% and 11% of cases with Mn/anti-Mn and radiology, respectively (P < 0.001). Mn and anti-Mn may be useful for early noninvasive diagnosis of IC...
  36. ncbi Identification and characterization of a neutralizing monoclonal antibody for the epitope on HM-1 killer toxin
    Dakshnamurthy Selvakumar
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 5 13 2 Kamishinei cho, Niigata 950 208
    J Biochem 139:399-406. 2006
    ..These results strongly indicate that nmAb-KT binds to HM-1 at the sequence 41GSTDGK46, and not to HYI at the same position. The potential active site of HM-1 involved in the killing activity against sensitive yeast is discussed...
  37. pmc A fungicidal monoclonal antibody protects against murine invasive candidiasis
    María J Sevilla
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Ciencia y Tecnologia, Universidad del Pais Vasco, Apartado 644, E 48080 Bilbao, Vizcaya, Spain
    Infect Immun 74:3042-5. 2006
    ..A prozone-like effect was observed. The in vitro candidacidal activity of macrophages was strongly enhanced when C. albicans was opsonized by C7 and complete murine serum was present...
  38. ncbi Antibody-mediated protective immunity in fungal infections
    Walter Magliani
    Sezione di Microbiologia, Dipartimento di Patologia e Medicina di Laboratorio, Universita degli Studi di Parma, Italy
    New Microbiol 28:299-309. 2005
    ..New perspectives of antibody-mediated therapy, based on the availability of monoclonal and recombinant antibodies as well as genetically engineered antibody fragments of defined specificity, will be also envisaged and discussed...
  39. ncbi Unexpected diversity in the fine specificity of monoclonal antibodies that use the same V region gene to glucuronoxylomannan of Cryptococcus neoformans
    Diane C McFadden
    Department of Medicine, Division of Infectious Disease, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 172:3670-7. 2004
    ....
  40. pmc Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2
    Manuel Vilanova
    Laboratório de Imunologia Mário Arala Chaves, Instituto de Ciencias Biomedicas de Abel Salazar, Largo do Prof Abel Salazar 2, 4099 003 Porto, Portugal
    Immunology 111:334-42. 2004
    ..Taken together, these analyses demonstrate that Sap2 can be successfully used as a vaccination target in systemic candidiasis and reveals the potential immunomodulatory role of Sap2 on C. albicans infection...
  41. ncbi Recombinant antibodies: a natural partner in combinatorial antifungal therapy
    Ruth C Matthews
    Medical Microbiology and NeuTec Pharma plc, 2nd Floor, Clinical Sciences Building 1, Central Manchester Healthcare Trust, Oxford Road, Manchester M13 9WL, UK
    Vaccine 22:865-71. 2004
    ..It is now the subject of a multinational, double-blind, placebo-controlled trial, in patients with culture-confirmed invasive candidiasis on liposomal amphotericin B...
  42. ncbi ELISA for early diagnosis of histoplasmosis
    Allan Jefferson Guimarães
    Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    J Med Microbiol 53:509-14. 2004
    ..It provides a useful adjunct to existing methods of diagnosis that could be applied even in situations where laboratory facilities were relatively limited...
  43. ncbi High seroprevalence of Pneumocystis infection in Spanish children
    N Respaldiza
    Research Unit, Virgen del Rocio University Hospital, Seville, Spain
    Clin Microbiol Infect 10:1029-31. 2004
    ..The data indicated a high seroprevalence of Pneumocystis infection in healthy Spanish children, thereby demonstrating that this pathogen is widespread in southern Spain...
  44. ncbi Antibody-mediated protection against intracellular pathogens
    A Casadevall
    Dept of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Trends Microbiol 6:102-7. 1998
    ..The challenge now is to identify antigens that elicit protective antibodies, use them in vaccine design and understand how humoral and cellular immune mechanisms cooperate...
  45. pmc Widespread occurrence of Pneumocystis carinii in commercial rat colonies detected using targeted PCR and oral swabs
    C R Icenhour
    Department of Infectious Disease, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267-0560, USA
    J Clin Microbiol 39:3437-41. 2001
    ..carinii f. sp. carinii DNA in all rat lungs, illustrating widespread occurrence of Pneumocystis in commercial rat colonies. Thus, oral swab/PCR is a rapid, nonlethal, and sensitive method for the assessment of Pneumocystis exposure...
  46. ncbi Analysis of the Paracoccidioides brasiliensis triosephosphate isomerase suggests the potential for adhesin function
    Luiz Augusto Pereira
    Laboratorio de Biologia Molecular, Instituto de Ciencias Biologicas, Universidade Federal de Goias, Goiania, Goias, Brazil
    FEMS Yeast Res 7:1381-8. 2007
    ..brasiliensis and extracellular matrix molecules such as laminin and that this interaction may play an important role in the fungal adherence and invasion of host cells...
  47. ncbi Diagnostic value of anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease
    M Peeters
    Department of Human Genetics, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Gastroenterol 96:730-4. 2001
    ..The combination of tests is probably more powerful, although, clinical subgroups still need to be defined. The usefulness of these markers in indeterminate colitis needs to be studied prospectively...
  48. pmc Fungicidal monoclonal antibody C7 binds to Candida albicans Als3
    Sonia Brena
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Apartado 699, E 48080 Bilbao, Vizcaya, Spain
    Infect Immun 75:3680-2. 2007
    ..It also bound the recombinant N terminus of Als3. Binding of MAb C7 to Als3 may explain the biological activities exerted by the MAb on C. albicans...
  49. pmc Transmission of Pneumocystis carinii DNA from a patient with P. carinii pneumonia to immunocompetent contact health care workers
    S L Vargas
    Program in Microbiology, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago
    J Clin Microbiol 38:1536-8. 2000
    ....
  50. ncbi Quantitation of anti-Pneumocystis jiroveci antibodies in healthy persons and immunocompromised patients
    Lisa R Bishop
    Critical Care Medicine Department, Warren G Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    J Infect Dis 187:1844-8. 2003
    ..This ELISA assay allows quantitation of anti-P. jiroveci antibodies in human serum samples and should be useful in better understanding the epidemiology of P. jiroveci infection in humans...
  51. ncbi Serologic responses to epitopes of the major surface glycoprotein of Pneumocystis jiroveci differ in human immunodeficiency virus-infected and uninfected persons
    Kieran R Daly
    Division of Infectious Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0560, USA
    J Infect Dis 186:644-51. 2002
    ..None of the serum samples drawn from 9 patients before they had developed PcP recognized MsgC. These data suggest that these novel recombinant proteins are useful for the analysis of antibody responses to Msg...
  52. pmc Glyceraldehyde-3-phosphate dehydrogenase of Paracoccidioides brasiliensis is a cell surface protein involved in fungal adhesion to extracellular matrix proteins and interaction with cells
    Mônica Santiago Barbosa
    Laboratorio de Biologia Molecular, Instituto de Ciencias Biologicas, Universidade Federal de Goias, Goiania, Goias, Brazil 74001 970
    Infect Immun 74:382-9. 2006
    ..brasiliensis could be involved in mediating binding of fungal cells to fibronectin, type I collagen, and laminin, thus contributing to the adhesion of the microorganism to host tissues and to the dissemination of infection...
  53. pmc Contribution of the Platelia Candida-specific antibody and antigen tests to early diagnosis of systemic Candida tropicalis infection in neutropenic adults
    Boualem Sendid
    Laboratoire de Mycologie Fondamentale et Appliquée et Equipe INSERM 0360, F 59045 Lille, France
    J Clin Microbiol 41:4551-8. 2003
    ..tropicalis systemic infection...
  54. pmc Antigen-induced protective and nonprotective cell-mediated immune components against Cryptococcus neoformans
    J W Murphy
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Infect Immun 66:2632-9. 1998
    ..Our results imply that there are protective and nonprotective cell-mediated immune responses and highlight the complexity of the immune response to C. neoformans antigens...
  55. ncbi An outline of the role of anti-Candida antibodies within the context of passive immunization and protection from candidiasis
    A Cassone
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Curr Mol Med 5:377-82. 2005
    ....
  56. ncbi Canine paracoccidioidomycosis: a seroepidemiologic study
    M A Ono
    , Escola Paulista de Medicina, Disciplina de Biologia Celular, Brazil
    Med Mycol 39:277-82. 2001
    ..These results indicate that ELISA and skin testing can be useful in the epidemiological study of paracoccidioidomycosis in dogs and that encounter with the fungus in nature is a frequent event...
  57. pmc Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis
    Robert A Larsen
    Department of Medicine Infectious Diseases, 2020 Zonal Ave, IRD Room 632, MC 9520, University of Southern California, Los Angeles, CA 90033, USA
    Antimicrob Agents Chemother 49:952-8. 2005
    ..The half-life of MAb 18B7 in serum was approximately 53 h, while the MAb was undetectable in the cerebrospinal fluid of all patients. These data support the continued investigation of MAb 18B7 at a maximum single dose of 1.0 mg/kg...
  58. ncbi Detection of IgG and IgM in sera from canines with blastomycosis using eight blastomyces dermatitidis yeast phase lysate antigens
    Christine M Sestero
    Department of Biological Sciences, Idaho State University, Box 8007, Pocatello, ID 83209, USA
    Mycopathologia 162:33-7. 2006
    ..310-0.744 for IgG, 0.025-0.069 for IgM). Inherent variations in yeast lysate antigens such as these may be utilized to develop improved immunoassay procedures for the specific detection of IgG or IgM in cases of blastomycosis...
  59. ncbi Induced humoral immunity and vaccination against major human fungal pathogens
    Arturo Casadevall
    Department of Medicine, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA
    Curr Opin Microbiol 5:386-91. 2002
    ..Protective monoclonal antibodies can be used to identify antigens that induce useful humoral responses...
  60. pmc Comparative evaluation of (1, 3)-beta-D-glucan, mannan and anti-mannan antibodies, and Candida species-specific snPCR in patients with candidemia
    Fasahat F Alam
    Department of Microbiology, Faculty of Medicine, Kuwait University, Safat 13110, P, O, Box 24923, Kuwait
    BMC Infect Dis 7:103. 2007
    ..In this retrospective study, attention has been focused to evaluate the usefulness of two or more disease markers in the diagnosis of candidemia...
  61. ncbi Insights into mechanisms of antibody-mediated immunity from studies with Cryptococcus neoformans
    A Casadevall
    Division of Infectious Diseases or the Department of Medicine and the Department of Microbiology and Immunology of the Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Curr Mol Med 5:421-33. 2005
    ..Observations with C. neoformans have stimulated a reappraisal of the role of humoral immunity for other pathogens and highlighted the limitations in current methods of assessing the role of Ab in host defense...
  62. ncbi Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis
    Flavia De Bernardis
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 00161 Rome, Italy
    J Infect Dis 195:149-57. 2007
    ..albicans. This is the first demonstration that human DAbs lacking the Fc constituent can efficiently control an infection and can act largely by inhibiting adherence...
  63. ncbi Identification of Candida albicans genes induced during thrush offers insight into pathogenesis
    Shaoji Cheng
    Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA
    Mol Microbiol 48:1275-88. 2003
    ....
  64. ncbi Anti-Saccharomyces cerevisiae antibodies--a novel serologic marker for Behçet's disease
    I Krause
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    Clin Exp Rheumatol 20:S21-4. 2002
    ..To evaluate the prevalence and clinical correlations of antibodies against Saccharomyces cerevisiae (ASCA) among patients with BD...
  65. ncbi Non-culture based diagnostic tests for mycotic infections
    E Reiss
    Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Med Mycol 38:147-59. 2000
    ..The identity of M antigen as a catalase was deduced from the sequence of the cloned gene. PCR identification of Histoplasma capsulatum cultures was accomplished with primer pairs selected from H and M antigen gene sequences...
  66. ncbi [Diagnosis of systemic Candida infections. Evaluation of serology, molecular biology and D-arabinitol detection]
    W Bar
    Institut für Mikrobiologie und Krankenhaushygiene, Carol Thiem Klinikum, Thiemstrasse 111, D 03048 Cottbus, Germany
    Mycoses 47:32-6. 2004
    ..In conclusion, serological methods (antigen and antibody detection) should only be applied in strictly selected patients. In uncertain cases, the addition of PCR or determination of D-arabinitol/L-arabinitol might be helpful...
  67. pmc Circulating beta (1-3) glucan and immunoglobulin G subclass antibodies to Candida albicans cell wall antigens in patients with systemic candidiasis
    N Kondori
    Department of Clinical Bacteriology, University of Goteborg, Goteborg, Sweden
    Clin Diagn Lab Immunol 11:344-50. 2004
    ..Furthermore, the kinetics of beta(1-3) glucan appearance in serum may assist in evaluating the therapeutic efficacy of antifungal treatments...
  68. pmc A proteomic-based approach for the identification of immunodominant Cryptococcus neoformans proteins
    Mattie Young
    Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249 0062, USA
    Proteomics 9:2578-88. 2009
    ....
  69. ncbi Paracoccidioides brasiliensis-reactive antibodies in Brazilian blood donors
    F A G Botteon
    Coordination Higher Level Professional Improvement Program, Federal University of Sao Paulo, Brazil
    Med Mycol 40:387-91. 2002
    ..The present report is the first epidemiological study using ELISA to detect antibodies against gp43 in blood donors...
  70. pmc ASCA: genetic marker, predictor of disease, or marker of a response to an environmental antigen?
    F Seibold
    Department of Gastroenterology, Inselspital, Freiburgstrasse, 3010 Bern, Switzerland
    Gut 54:1212-3. 2005
  71. ncbi B1 cells contribution to susceptibility in experimental paracoccidioidomycosis: immunoglobulin isotypes and repertoire determination
    Karla Marcelino França
    Laboratorio de Biologia do Reconhecer, Centro de Biociencias e Biotecnologia, Universidade Estadual do Norte Fluminense, Campos dos Goytacazes, RJ, Brazil
    Med Mycol 44:755-66. 2006
    ....
  72. pmc Diagnosis of neuroparacoccidioidomycosis by detection of circulating antigen and antibody in cerebrospinal fluid
    Silvia Helena Marques da Silva
    Department of Microbiology, Immunology and Parasitology, Federal de São Paulo, Brazil
    J Clin Microbiol 43:4680-3. 2005
    ..In addition, the finding of anti-gp43 and anti-gp70 antibodies in CSF samples by conventional ELISA also seems to be a promising diagnostic method for this special modality of PCM...
  73. pmc Syscan3, a kit for detection of anti-Candida antibodies for diagnosis of invasive candidiasis
    Annie Philip
    Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas Houston Medical School, 77030, USA
    J Clin Microbiol 43:4834-5. 2005
    ..7%, and 93% in the immunocompromised group, respectively. Syscan3 has high negative predictive value...
  74. pmc Serological detection of antibodies against Paracoccidioides brasiliensis in dogs with leishmaniasis
    L H Silveira
    Departamento de Ciências Patológicas, Centro de Ciencias Biologicas, Universidade Estadual de Londrina, Campus Universitario, Londrina, Parana, 86051 980, Brazil
    Mycopathologia 162:325-9. 2006
    ..brasiliensis antigens may be due to cross-reactivity or a co-infection of dogs by Leishmania and P. brasiliensis. The lower correlation (0.187) observed between reactivity to gp43 and Leishmania antigen reinforces the latter hypothesis...
  75. ncbi Membrane and extracellular antigens of Paracoccidioides brasiliensis (Mexo): identification of a 28-kDa protein suitable for immunodiagnosis of paracoccidioidomycosis
    B S Reis
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Belo Horizonte, MG, Brazil
    J Immunol Methods 307:118-26. 2005
    ..Since the 28-kDa protein of P. brasiliensis seems to be specific for PCM, it can be used as an alternative antigen in immunoblotting diagnostic methods...
  76. pmc Use of recombinant antigens for the diagnosis of invasive candidiasis
    Ana Laín
    Departamento de Inmunologia, Microbiologia y Parasitologia, Facultad de Medicina y Odontologia, Universidad del Pais Vasco, Apartado 699, 48080 Bilbao, Vizcaya, Spain
    Clin Dev Immunol 2008:721950. 2008
    ..In this review we will discuss the usefulness of recombinant antigens in the diagnosis of invasive candidiasis...
  77. ncbi Colonization of mice by Candida albicans is promoted by chemically induced colitis and augments inflammatory responses through galectin-3
    Samir Jawhara
    Inserm U 799, Physiopathologie des Candidoses, Faculte de Medecine, Centre Hospitalier Regional Universitaire de Lille, Institut Fédératif de Recherche 114, Universite Lille 2, Lille, France
    J Infect Dis 197:972-80. 2008
    ..Little is known about the relationship between colonic inflammation and Candida albicans colonization. Galectin-3 (Gal-3) is an intestinal lectin that binds to specific C. albicans glycans and is involved in inflammation...
  78. ncbi Evaluation of the usefulness of anti-glyceraldehyde-3-phosphate dehydrogenase antibodies as a treatment for invasive candidiasis in a murine model
    Maria Luisa Gil
    Departament de Microbiologia i Ecologia, Universitat de Valencia, Avda Vicent Andres Estelles s n, 46100, Burjassot, Spain
    Antonie Van Leeuwenhoek 89:345-50. 2006
    ....
  79. ncbi Protection induced in BALB/c mice by the high-molecular-mass (hMM) fraction of Paracoccidioides brasiliensis
    Wander R Pavanelli
    Fundação Araucária, Curitiba, PR, Brazil
    Mycopathologia 163:117-28. 2007
    ..05) were observed in immunized groups. The results for CFU, histopathology and antigenemia suggest that the hMM fraction has a protective effect in experimental paracoccidioidomycosis in BALB/c mice...
  80. ncbi Immune responsiveness of a novel peptidoglycan conjugate prepared from surface Candida immunogens: mannan and CR3-related protein
    Ema Paulovicova
    Center for Glycomics, Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia
    FEMS Immunol Med Microbiol 53:421-8. 2008
    ..Altogether, it could be assumed that the novel peptide glycoconjugate is a prospective antigenic candidate for further Candida vaccine design...
  81. pmc Use of sera from humans and dolphins with lacaziosis and sera from experimentally infected mice for Western Blot analyses of Lacazia loboi antigens
    Leonel Mendoza
    Biomedical Laboratory Diagnostics Program, Michigan State University, 322 North Kedzie Hall, East Lansing, MI 48824 1031, USA
    Clin Vaccine Immunol 15:164-7. 2008
    ..loboi extracts. This study is the first to examine the humoral response to L. loboi antigens by using multiple host sera...
  82. ncbi Isolates of Candida albicans that differ in virulence for mice elicit strain-specific antibody-mediated protective responses
    Y Hu
    Department of Oral Biology and Pathology, School of Dentistry, University of Queensland, Brisbane, QLD 4072, Australia
    Microbes Infect 8:612-20. 2006
    ..Thus, different strains of yeast show considerable specificity in antibody responses elicited by either systemic or oral infection...
  83. ncbi The GPI-anchored Gas and Crh families are fungal antigens
    Javier Arroyo
    Departamento Microbiología II, Facultad de Farmacia, Universidad Complutense, Madrid 28040, Spain
    Yeast 24:289-96. 2007
    ..These results suggest that GPI-anchored cross-linking enzymes are relevant immunologically reactive constituents of the cell wall that may play a role during human fungal infections...
  84. ncbi Aspergillus antigens: which are important?
    V P Kurup
    Department of Pediatrics, Allergy lmmunology Division, Medical College of Wisconsin, USA
    Med Mycol 43:S189-96. 2005
    ..Antigens can be engineered with less or more binding with IgE, and such antigens may have significant roles as specific reagents or as immunomodulators...
  85. pmc Evaluation of a rapid immunochromatographic assay for identification of Candida albicans and Candida dubliniensis
    Agnes Marot-Leblond
    Groupe d Etude des Interactions Hôte Parasite, UPRES EA 3142, UFR de Sciences Pharmaceutiques et d Ingénierie de la Santé, Angers, France
    J Clin Microbiol 42:4956-60. 2004
    ..1 to 100%. These parameters decreased, however, to 91.4% when the test was performed with yeast isolated with Candida ID...
  86. pmc Serological differentiation of experimentally induced Candida dubliniensis and Candida albicans infections
    M D Moragues
    , , , E-48080 Bilbao, Vizcaya, Spain
    J Clin Microbiol 39:2999-3001. 2001
    ..These results confirm our previous observation in a patient with C. dubliniensis candidemia and suggest that detection of C. dubliniensis-specific antibodies is useful in the diagnosis of invasive candidiasis caused by this yeast...
  87. ncbi Candida albicans cell wall antigens for serological diagnosis of candidemia
    N Kondori
    Department of Clinical Bacteriology, Goteborg University, Guldhedsgatan 10, S 413 46 Goteborg, Sweden
    Med Mycol 41:21-30. 2003
    ..In conclusion, IgG antibodies to PPM and native cell wall fragments (CW) were highly discriminatory for recognition of candidemia and these antigens are thus promising candidates for use in serodiagnosis...
  88. pmc Combined use of Paracoccidioides brasiliensis recombinant 27-kilodalton and purified 87-kilodalton antigens in an enzyme-linked immunosorbent assay for serodiagnosis of paracoccidioidomycosis
    Soraya Diez
    St John s Institute of Dermatology, Guy s Hospital, London, England
    J Clin Microbiol 41:1536-42. 2003
    ..Thus, the use of combinations of well-defined antigens appears to offer clear advantages over the use of single antigens when diagnosing PCM...
  89. ncbi [Serum levels of antibodies for IgG, IgA, and IgM against the fungi antigen in psoriasis vulgaris]
    Yun sheng Liang
    Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Hunan Yi Ke Da Xue Xue Bao 28:638-40. 2003
    ..To detect the serum levels of antibodies against Malassezia further and Candida albicans in patients with psoriasis vulgaris (PV), and to investigate the relationship between Malassezia furfur or Candida albicans and pathogenesis of PV...
  90. pmc A monoclonal antibody directed against a Candida albicans cell wall mannoprotein exerts three anti-C. albicans activities
    María D Moragues
    Departamento de Enfermería I, Universidad del Pais Vasco, E 48080 Bilbao, Vizcaya, Spain
    Infect Immun 71:5273-9. 2003
    ..Results presented in this study support the concept of a family of microbicidal antibodies that could be useful in the treatment of a wide range of microbial infections when used alone or in combination with current antimicrobial agents...
  91. ncbi Value of Candida antigen and antibody assays for the diagnosis of invasive candidosis in surgical intensive care patients
    P M Lepper
    Department of Medical Microbiology and Hygiene, Ulm University Hospital, Germany
    Intensive Care Med 27:916-20. 2001
    ..Thus, the Candida HA antibody test, but not the Ramco antigen test, can be recommended to confirm a clinical diagnosis of invasive candidosis...
  92. ncbi [Diagnostic value of antibody detection against Candida germ tube antigens in a patient with hepatosplenic candidosis]
    G G Wulf
    Abteilung Hämatologie und Onkologie, Universitätsklinikum Göttingen, Robert Koch Strasse 40, D 37099 Göttingen, Germany
    Mycoses 47:11-4. 2004
    ..In the case of this patient, the detection of a humoral response against Candida germ tube antigens was of little diagnostic value...
  93. ncbi Protective immunity induced in mice by F0 and FII antigens purified from Paracoccidioides brasiliensis
    S N Diniz
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Caixa Postal 486, CEP 32270 901, Belo Horizonte, MG, Brazil
    Vaccine 22:485-92. 2004
    ..Taken together, these findings suggest that antigens of F0 and FII are reliable vaccine candidates against the paracoccidioidomycosis...
  94. pmc Negative immunodiffusion test results obtained with sera of paracoccidioidomycosis patients may be related to low-avidity immunoglobulin G2 antibodies directed against carbohydrate epitopes
    Andreia R Neves
    Department of Clinical Pathology, Faculty of Medical Sciences, State University of Campinas UNICAMP, Campinas, Brazil
    Clin Diagn Lab Immunol 10:802-7. 2003
    ..These data suggest that the lack of reactivity of sera from PCM patients in the ID test may be related to the production of low-avidity IgG2 antibodies directed against carbohydrate epitopes...
  95. ncbi Antibody response to Candida albicans cell wall antigens
    Jose L Lopez-Ribot
    Department of Medicine, Division of Infectious Diseases, The University of Texas Health Sciences Center, San Antonio, USA
    FEMS Immunol Med Microbiol 41:187-96. 2004
    ..albicans may provide the basis for the development of (i) effective procedures for the serodiagnosis of disseminated candidiasis, and (ii) novel prophylactic (vaccination) and therapeutic strategies to control this type of infections...
  96. ncbi Antibody isotypes to a Paracoccidioides brasiliensis somatic antigen in sub-acute and chronic form paracoccidioidomycosis
    M Juvenale
    , , Brazil
    J Med Microbiol 50:127-34. 2001
    ..Immunoblot analysis showed that, in addition to the 43-kDa immunodominant fraction, other less well-characterised fractions were also recognised differentially by the isotypes and deserve further investigation...
  97. ncbi Immune sensitization to yeast antigens in ASCA-positive patients with Crohn's disease
    Astrid Konrad
    Division of Gastroenterology, Inselspital, University of Bern, Freiburgstrasse, Switzerland
    Inflamm Bowel Dis 10:97-105. 2004
    ..A proportion of CD patients develop antibodies against the yeast Saccharomyces cerevisiae (ASCA), but little is known about the cellular immune reactivity against food antigens in antibody-positive and -negative patients...
  98. ncbi A new glycoprotein allergen/antigen with the protease activity from Aspergillus fumigatus
    Shailly Nigam
    Molecular Biochemistry and Diagnostics Division, Centre for Biochemical Technology, Delhi, India
    Int Arch Allergy Immunol 132:124-31. 2003
    ..It secretes an array of complex biologically active glycoprotein antigens and allergens. It is important to identify and characterize probable potential virulent factors playing a major role in the pathogenesis of aspergillosis...
  99. ncbi Increased resistance in BALB/c mice to reinfection with Candida albicans is due to immunoneutralization of a virulence-associated immunomodulatory protein
    Delfina Tavares
    Laboratories of Microbiology, Institute for Biomedical Sciences Abel Salazar ICBAS, University of Porto, Porto, Portugal
    Microbiology 149:333-9. 2003
    ..albicans, after treatment of the animals with anti-p43 antibodies. The data described here provide a biological explanation for active immunoprotection achieved after spontaneous healing of infectious diseases, namely in candidiasis...
  100. pmc Improvement of the specificity of an enzyme-linked immunosorbent assay for diagnosis of paracoccidioidomycosis
    C F Albuquerque
    Department of Microbiology, Immunology and Parasitology, Cellular Biology Discipline, Federal University of Sao Paulo, Brazil
    J Clin Microbiol 43:1944-6. 2005
    ..The maximum specificity found in this ELISA was 84%. All of these procedures proved inefficient for eliminating all cross-reacting antibodies and obtaining an ELISA specific for PCM diagnosis...
  101. ncbi Candida and allergy
    A G Palma-Carlos
    Medical Clinic, Hematology Immunology Center, Lisbon Faculty of Medicine, and Clinical Allergy Immunology Center, Lisbon, Portugal
    Allerg Immunol (Paris) 34:322-4. 2002
    ....

Research Grants37

  1. Monoclonal antibodies to inhibit Aspergillus germination
    MARTA L FELDMESSER; Fiscal Year: 2010
    ..It is anticipated that this study will identify fungal molecules important for germination and begin to define their interaction with host immune responses. ..
  2. MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIES
    Arturo Casadevall; Fiscal Year: 2006
    ..These studies are expected to yield new insights on fundamental aspects of antibody function as well as practical information for the development of second generation antibody reagents for human therapy. ..
  3. Mining slime mold for susceptibility genes to fungi
    Arturo Casadevall; Fiscal Year: 2005
    ..discoideum system will lead to the identification of genetic pathways that are not immediately obvious from standard fungal-macrophage experiments. ..
  4. Aspergillosis: Engineering Antibody for Diagnosis
    Marta Feldmesser; Fiscal Year: 2006
    ..The availability of reagents that have potential to improve both sensitivity and specificity of galactomannan detection would be a significant advance. ..
  5. MELANOGENESIS IN CRYPTOCOCCUS NEOFORMANS
    JOSHUA NOSANCHUK; Fiscal Year: 2002
    ..To explore the structure of melanin using biochemistry, phage display peptide libraries and mAbs; and 4. To use peptides and mAbs to study C. neoformans melanogenesis in vivo and in vitro. ..
  6. Antibody Protection in Histoplamosis
    JOSHUA NOSANCHUK; Fiscal Year: 2009
    ..These studies are expected to lead to insights into H. capsulatum pathogenesis and initiate the development of new therapeutic and diagnostic reagents. ..
  7. Monoclonal antibodies for invasive aspergillosis
    Marta Feldmesser; Fiscal Year: 2003
    ..To determine the biological activity of MAbs generated in Aim 2 in murine models of invasive aspergillosis. It is anticipated that this study will identify important targets for further investigation. ..
  8. CANDIDA ALBICANS SURFACE ANTIGENS
    Jim Cutler; Fiscal Year: 2006
    ....
  9. HUMAN ANTIBODIES TO CRYPTOCOCCUS NEOFORMANS
    Liise Anne Pirofski; Fiscal Year: 2009
    ..neoformans and provide proof of principle that vaccines can be developed that focus the immune response on cellular subsets that can induce protection: ..
  10. Parental Expression of Immune Responses In Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  11. Serum Antibodies to Recombinant Pneumocystis Antigens
    Peter Walzer; Fiscal Year: 2009
    ..Data obtained from these studies will lead to the first standard antigen for PC serologic studies, and enhance our understanding of the epidemiology and immunology of PC infection. ..
  12. Host control in Coccidioidomycosis
    John Galgiani; Fiscal Year: 2008
    ..We will also analyze the phenotype, function and cytokine profiles of lymphocyte subsets that respond to antigen-pulsed DC. ..
  13. P CARINII PNEUMONIA--IMMUNOPATHOGENESIS OF LUNG INJURY
    Francis Gigliotti; Fiscal Year: 2001
    ..If this hypothesis is proven correct, the information gained from the proposed studies can be utilized to develop new therapeutic modalities to improve the morbidity and mortality resulting from PCP. ..
  14. Role of Fungal Microflora in Mucosal Tolerance/Immunity
    GARY HUFFNAGLE; Fiscal Year: 2009
    ..These studies will provide the basic science foundation for future studies in humans for understanding how and why manipulation of the microflora (by diet or probiotics) can alter or prevent allergies. ..
  15. Antifungal Drug Susceptibility of Cryptococcus neoformans
    Robert Larsen; Fiscal Year: 2009
    ....
  16. VARIABLE GENE USE AND PNEUMOCOCCAL IMMUNITY IN AIDS
    Liise Anne Pirofski; Fiscal Year: 2010
    ..pneumoniae that will translate into identification of new correlates of vaccine efficacy and the generation of hypotheses for future testing in human studies. ..
  17. VARIABLE GENE DEFECTS AND PNEUMOCOCCAL SUSCEPTIBILITY
    Liise Anne Pirofski; Fiscal Year: 2010
    ..The proposed studies will advance our understanding of how pneumococcal vaccine works. ..
  18. Pneumocystis in Pathogenesis of HIV-associated Emphysema
    Alison Morris; Fiscal Year: 2009
    ..This information will help us understand and treat emphysema in these patients and in the many non-HIV-infected people who suffer from this disease. ..
  19. MONOCLONAL ANTIBODIES FOR THE STUDY OF P. CARINII
    Francis Gigliotti; Fiscal Year: 2009
    ..We will also determine the microbiologic effect of combining passive antibody therapy with conventional antimicrobial therapy. ..
  20. Role of Oxylipins in Cryptococcal Pathogenesis
    GARY HUFFNAGLE; Fiscal Year: 2008
    ..production; (3) to determine the role of the fungal oxylipin CnPGEx in cryptococcal biology and pathogenesis; (4) to determine the role of host PGE2 and other prostaglandins in cryptococcal biology and host immunity ..
  21. The Natural History of Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..abstract_text> ..
  22. MUCOSAL CELL MEDIATED IMMUNITY IN VAGINAL CANDIDIASIS
    Paul Fidel; Fiscal Year: 2006
    ..The long term goal is to understand vaginal host defense mechanisms against C. albicans so that immunotherapeutic strategies can be developed to prevent or treat disease. ..
  23. CHEMOKINE RECEPTORS IN IMMUNITY TO C NEOFORMANS
    GARY HUFFNAGLE; Fiscal Year: 2003
    ..neoformans infection; (5) To determine the role of MCP-1 and CCR2 in the development of a Th2 response to C. neoformans. ..
  24. MUCOSAL IMMUNIZATION--PREVENTION OF SYSTEMIC CANDIDIASIS
    LUCY FREYTAG; Fiscal Year: 2003
    ..abstract_text> ..
  25. MOLECULAR BASIS OF PHENOTYPIC SWITCHING IN 24067 MUTANT
    Bettina Fries; Fiscal Year: 2003
    ..The second part is designed to clone the gene mediating this complex phenotype and the third part will aim to establish whether there is a causative relationship between chromosomal rearrangement and switching. ..
  26. Antibody epitopes of Pneumocystis in HIV patients
    Kieran Daly; Fiscal Year: 2004
    ..These newly identified epitopes will, in the long term, be used to probe immune reactivity in HIV+ patients undergoing HAART. ..
  27. MODULATION OF TH1/TH2 RESPONSES BY INNATE IMMUNITY
    GARY HUFFNAGLE; Fiscal Year: 2004
    ..One of the potential implications of these studies is that therapies inhibiting melanin biosynthesis or activity may also have an adjuvant effect and promote the development of protective Th1 immunity to C. neoformans. ..
  28. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  29. 8th ASM Conference on Candida and Candidiasis
    Paul Fidel; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  30. Nikkomycin Z Treatment for Coccidioidomycosis
    John Galgiani; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  31. ORAL IMMUNE DYSFUNCTION AND CANDIDIASIS IN HIV INFECTION
    Paul Fidel; Fiscal Year: 2007
    ..abstract_text> ..
  32. NOVEL IMMUNIZATION STRATEGIES AGAINST ANTHRAX
    LUCY FREYTAG; Fiscal Year: 2006
    ..This information may also be valuable in the development of similar prevention strategies against other potential agents of biowarfare/bioterrorism. ..
  33. Epidemiology and Significance of P carinii Colonization
    Alison Morris; Fiscal Year: 2007
    ..In addition, greater insight into the epidemiology of colonization may aid in understanding the transmission and prevention of P. carinii. ..
  34. SP-A MOUSE MODELS OF PNEUMOCYSTIS INFECTION
    Peter Walzer; Fiscal Year: 2004
    ..3) analyze the influence of SP-A on the host immune/inflammatory response that occurs during the recovery from PcP. ..
  35. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..
  36. Antibody in Defense Against Neonatal Candida Infections
    JOSEPH BLISS; Fiscal Year: 2008
    ..As such, he will be in an ideal position to orchestrate the translation of basic science to the benefit of patients. ..
  37. Mucosal Defense vs Transmission of HIV by Breast Milk
    Edward Janoff; Fiscal Year: 2006
    ....