bacterial antibodies

Summary

Summary: Immunoglobulins induced by substances elaborated by BACTERIA that have an antigenic activity.

Top Publications

  1. pmc A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells
    S Knutton
    Institute of Child Health, University of Birmingham, Birmingham B16 8ET, UK
    EMBO J 17:2166-76. 1998
  2. ncbi Anti-staphylococcal humoral immune response in persistent nasal carriers and noncarriers of Staphylococcus aureus
    Nelianne J Verkaik
    Departments of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 199:625-32. 2009
  3. ncbi Herd-level economic losses associated with Johne's disease on US dairy operations
    S L Ott
    Center for Epidemiology, US Department of Agriculture, Fort Collins, CO 80521, USA
    Prev Vet Med 40:179-92. 1999
  4. ncbi Reclassification of Staphylococcus aureus nasal carriage types
    Alex van Belkum
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    J Infect Dis 199:1820-6. 2009
  5. ncbi Efficacy of a pneumococcal conjugate vaccine against acute otitis media
    J Eskola
    National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:403-9. 2001
  6. pmc The hypothetical protein CT813 is localized in the Chlamydia trachomatis inclusion membrane and is immunogenic in women urogenitally infected with C. trachomatis
    Chaoqun Chen
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    Infect Immun 74:4826-40. 2006
  7. pmc Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice
    H Su
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 65:1993-9. 1997
  8. ncbi Meningococcal surrogates of protection--serum bactericidal antibody activity
    Ray Borrow
    Meningococcal Reference Unit, Health Protection Agency North West Laboratory, Manchester Royal Infirmary, Manchester M13 9WZ, UK
    Vaccine 23:2222-7. 2005
  9. pmc Household transmission of leptospira infection in urban slum communities
    Elves A P Maciel
    Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Ministerio da Saude, Salvador, Bahia, Brazil
    PLoS Negl Trop Dis 2:e154. 2008
  10. ncbi Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants
    Luis Jodar
    Department of Vaccines and Biologicals, World Health Organization, CH 1211 27, Geneva, Switzerland
    Vaccine 21:3265-72. 2003

Detail Information

Publications319 found, 100 shown here

  1. pmc A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells
    S Knutton
    Institute of Child Health, University of Birmingham, Birmingham B16 8ET, UK
    EMBO J 17:2166-76. 1998
    ....
  2. ncbi Anti-staphylococcal humoral immune response in persistent nasal carriers and noncarriers of Staphylococcus aureus
    Nelianne J Verkaik
    Departments of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 199:625-32. 2009
    ..Persistent carriers have a higher risk of Staphylococcus aureus infections than noncarriers but a lower risk of bacteremia-related death. Here, the role played by anti-staphylococcal antibodies was studied...
  3. ncbi Herd-level economic losses associated with Johne's disease on US dairy operations
    S L Ott
    Center for Epidemiology, US Department of Agriculture, Fort Collins, CO 80521, USA
    Prev Vet Med 40:179-92. 1999
    ..Averaged across all herds, Johne's disease costs the US dairy industry, in reduced productivity, US$ 22 to US$ 27 per cow or US$ 200 to US$ 250 million annually...
  4. ncbi Reclassification of Staphylococcus aureus nasal carriage types
    Alex van Belkum
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    J Infect Dis 199:1820-6. 2009
    ..This study was performed to provide additional insight into staphylococcal carriage types...
  5. ncbi Efficacy of a pneumococcal conjugate vaccine against acute otitis media
    J Eskola
    National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:403-9. 2001
    ..CONCLUSIONS: The heptavalent pneumococcal polysaccharide-CRM197 conjugate vaccine is safe and efficacious in the prevention of acute otitis media caused by the serotypes included in the vaccine...
  6. pmc The hypothetical protein CT813 is localized in the Chlamydia trachomatis inclusion membrane and is immunogenic in women urogenitally infected with C. trachomatis
    Chaoqun Chen
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    Infect Immun 74:4826-40. 2006
    ..Thus, the CT813 protein may represent an important candidate for understanding C. trachomatis pathogenesis and developing intervention and prevention strategies for controlling C. trachomatis infection...
  7. pmc Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice
    H Su
    Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
    Infect Immun 65:1993-9. 1997
    ..Therefore, these data suggest that both humoral and cell-mediated immune responses were important mediators of immune protection in this model, though cell-mediated immune responses appear to play a more dominant role...
  8. ncbi Meningococcal surrogates of protection--serum bactericidal antibody activity
    Ray Borrow
    Meningococcal Reference Unit, Health Protection Agency North West Laboratory, Manchester Royal Infirmary, Manchester M13 9WZ, UK
    Vaccine 23:2222-7. 2005
    ..SBA activity as a correlate of protection for evaluating the immune response to meningococcal vaccines is described in this review...
  9. pmc Household transmission of leptospira infection in urban slum communities
    Elves A P Maciel
    Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Ministerio da Saude, Salvador, Bahia, Brazil
    PLoS Negl Trop Dis 2:e154. 2008
    ..However, slum inhabitants reside in close proximity to environmental sources of contamination, suggesting that transmission during urban epidemics occurs in the household environment...
  10. ncbi Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants
    Luis Jodar
    Department of Vaccines and Biologicals, World Health Organization, CH 1211 27, Geneva, Switzerland
    Vaccine 21:3265-72. 2003
    ..More detailed recommendations for production and control of pneumococcal conjugate vaccines, including criteria for evaluation for licensure, are currently being drafted...
  11. ncbi Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage
    Simon R Clarke
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom
    J Infect Dis 193:1098-108. 2006
    ..aureus to human desquamated nasal epithelial cells and is required for nasal colonization in the cotton rat model. Thus, vaccination with these antigens may prevent S. aureus carriage and reduce the prevalence of human disease...
  12. pmc Antibody-mediated disease remission in the mouse model of lyme borreliosis
    Stephen W Barthold
    Center for Comparative Medicine, School of Medicine, University of California at Davis, One Shields Avenue, Davis, California 95616, USA
    Infect Immun 74:4817-25. 2006
    ..These results suggest that Arp and DbpA antibodies may be active as disease-resolving components in immune serum but antibody against other antigens may be involved in reductions of spirochetes in tissues...
  13. ncbi Development of antibodies to Burkholderia pseudomallei during childhood in melioidosis-endemic northeast Thailand
    Vanaporn Wuthiekanun
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    Am J Trop Med Hyg 74:1074-5. 2006
    ..There was a sharp rise in detectable antibodies from birth to 4 years followed by reactivity in approximately 60-70% of children thereafter...
  14. pmc Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages
    Ashwin Balagopal
    Department of Internal Medicine, Ohio State University, 420 W 12th Avenue, 216 Tzagournis Medical Research Facility, Columbus, OH 43210, USA
    Infect Immun 74:5114-25. 2006
    ..This study demonstrates that human macrophages phagocytose more Francisella than monocytes with contributions from CR3, Fcgamma receptors, the MR, and SP-A present in lung alveoli...
  15. pmc Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vector
    James M Battisti
    Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, USA
    Infect Immun 76:5228-37. 2008
    ..We conclude that OspA serves a critical antibody-shielding role during vector blood meal uptake from immune hosts and is not required for persistence in the tick vector...
  16. ncbi The 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) coadministered with DTPw-HBV/Hib and poliovirus vaccines: assessment of immunogenicity
    Nancy Bermal
    Research Institute for Tropical Medicine, Filinvest Corporate City, Alabang, Muntinlupa City, The Philippines
    Pediatr Infect Dis J 28:S89-96. 2009
    ....
  17. pmc Chlamydia trachomatis IncA is localized to the inclusion membrane and is recognized by antisera from infected humans and primates
    J P Bannantine
    Department of Microbiology, Oregon State University, Corvallis, Oregon 97331 3804, USA
    Infect Immun 66:6017-21. 1998
    ..psittaci IncA and is also localized to the inclusion membrane. Immunoblot analysis demonstrated that sera from C. trachomatis-infected patients and from experimentally infected monkeys both recognized C. trachomatis IncA...
  18. ncbi Leptospira and leptospirosis
    Ben Adler
    Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Australia
    Vet Microbiol 140:287-96. 2010
    ..However, the recent development of defined mutagenesis systems for Leptospira heralds the potential for gaining a much improved understanding of pathogenesis in leptospirosis...
  19. pmc Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax
    Mark T Albrecht
    Biological Defense Research Directorate, Naval Medical Research Center, 12300 Washington Ave, Silver Spring, MD 20910 7500, USA
    Infect Immun 75:5425-33. 2007
    ..Based on these results, IQNPA and IQNLF act independently during prophylactic anthrax treatment and do not interfere with the establishment of endogenous immunity...
  20. pmc A double-blind randomized placebo-controlled phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patients
    Gerd Doring
    Institute of Medical Microbiology and Hygiene, Wilhelmstrasse 31, D 72074 Tubingen, Germany
    Proc Natl Acad Sci U S A 104:11020-5. 2007
    ..Active immunization of patients with cystic fibrosis lowers the risk for infection with P. aeruginosa and therefore may contribute to a longer survival of these patients...
  21. pmc Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review
    Karen R Steingart
    Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America
    PLoS Med 4:e202. 2007
    ..Currently, dozens of distinct commercial antibody detection tests are sold in developing countries. The question is "do they work?"..
  22. ncbi Binding of human C4BP to the hypervariable region of M protein: a molecular mechanism of phagocytosis resistance in Streptococcus pyogenes
    K Berggård
    Department of Medical Microbiology, Dermatology and Infection, Lund University, Solvegatan 23, SE 223 62 Lund, Sweden
    Mol Microbiol 42:539-51. 2001
    ..This study provides the first molecular insight into the mechanisms by which the HVR of an M protein confers phagocytosis resistance...
  23. ncbi Prevalence of antibodies against Mycobacterium avium subsp paratuberculosis among beef cow-calf herds
    D A Dargatz
    USDA Animal and Plant Health Inspection Service, Centers for Epidemiology and Animal Health, Ft Collins, CO 80521, USA
    J Am Vet Med Assoc 219:497-501. 2001
    ..CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that the prevalence of antibodies to M avium subsp paratuberculosis among beef cows in the United States is low. Herds with seropositive animals were widely distributed geographically...
  24. ncbi Transitions in immune responses to Mycobacterium paratuberculosis
    J R Stabel
    USDA ARS, National Animal Disease Center, Ames, IA 50010, USA
    Vet Microbiol 77:465-73. 2000
    ..This paper reviews the current knowledge of T cell immune responses in M. paratuberculosis infection based upon clinical studies and research using mouse models...
  25. ncbi Albendazole treatment of children with ascariasis enhances the vibriocidal antibody response to the live attenuated oral cholera vaccine CVD 103-HgR
    P J Cooper
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Infect Dis 182:1199-206. 2000
    ..lumbricoides infections impair the immune response to oral cholera vaccine, particularly in subjects of non-O blood groups...
  26. ncbi Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon- gamma
    Craig R Cohen
    Department of Obstetrics, Gynecology, and Reproductive Science, University of California, San Francisco, San Francisco, California 94105, USA
    J Infect Dis 192:591-9. 2005
    ..This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development...
  27. ncbi Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
    Stephan R Targan
    Cedars Sinai Inflammatory Bowel Disease Center, Los Angeles, California 90048, USA
    Gastroenterology 128:2020-8. 2005
    ....
  28. pmc Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses
    Fang Ting Liang
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8031, USA
    Infect Immun 72:5759-67. 2004
    ..This change in antigenic expression could be induced by passively immunizing infected severe combined immunodeficiency mice with specific Borrelia antisera or OspC antibody and appears to allow B. burgdorferi to resist immune attack...
  29. ncbi Invasive group A streptococcal infections: T1M1 isolates expressing pyrogenic exotoxins A and B in combination with selective lack of toxin-neutralizing antibodies are associated with increased risk of streptococcal toxic shock syndrome
    B K Eriksson
    Division of Infectious Diseases, Department of Immunology, Karolinska Institute, Huddinge University Hospital, Sweden
    J Infect Dis 180:410-8. 1999
    ..Neutralization of SpeB was significantly lower in sera of patients with STSS than in sera from persons with bacteremia or erysipelas...
  30. ncbi Differences in the avidity of antibodies evoked by four different pneumococcal conjugate vaccines in early childhood
    M Anttila
    Department of Vaccines, National Public Health Institute, Helsinki, Finland
    Vaccine 17:1970-7. 1999
    ..No vaccine specific differences were found in avidity of anti-14 or -19F antibodies. By contrast, antibody avidity to 6B and 23F differed significantly between the vaccine groups, PncCRM and PncT inducing antibodies of highest avidity...
  31. ncbi Experimental Corynebacterium pseudotuberculosis primary infection in goats: kinetics of IgG and interferon-gamma production, IgG avidity and antigen recognition by Western blotting
    B J A Paule
    Laboratorio de Imunologia, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Av Reitor Miguel Calmon, S N Vale do Canela, CEP 40140 100, Salvador BA, Brazil
    Vet Immunol Immunopathol 96:129-39. 2003
    ..Both humoral and cellular responses kinetics presented a similar pattern of activation/deactivation but necropsy results suggested that the IFN-gamma test would be a very specific marker of CLA status...
  32. pmc A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection
    Sandra G Morrison
    Division of Infectious Diseases, Department of Medicine, University of Alabama, Birmingham 35294 0007, USA
    J Immunol 175:7536-42. 2005
    ..These results impact our understanding of immunity to chlamydial genital infection and may provide important insight into vaccine development...
  33. ncbi MyD88 plays a unique role in host defense but not arthritis development in Lyme disease
    Devin D Bolz
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Immunol 173:2003-10. 2004
    ..The findings presented here point to a dichotomy between the recruitment of inflammatory cells to tissue and an inability of these cells to kill localized spirochetes...
  34. pmc Early antibody responses to experimental Mycobacterium bovis infection of cattle
    W R Waters
    Bacterial Diseases of Livestock Research Unit, Agricultural Research Service, National Animal Disease Center, United States Department of Agriculture, P O Box 70, Ames, IA 50010 0070, USA
    Clin Vaccine Immunol 13:648-54. 2006
    ..These findings demonstrate the potential for new-generation antibody-based tests for the early detection of M. bovis infection in cattle...
  35. pmc Fine and domain-level epitope mapping of botulinum neurotoxin type A neutralizing antibodies by yeast surface display
    R Levy
    Department of Anesthesia and Pharmaceutical Chemistry, University of California, San Francisco, San Francisco General Hospital, CA 94110, USA
    J Mol Biol 365:196-210. 2007
    ..The results demonstrate how yeast display can be used for domain-level and fine mapping of conformational BoNT antibody epitopes and the mapping results identify three neutralizing BoNT/A epitopes...
  36. pmc Impaired opsonization with C3b and phagocytosis of Streptococcus pneumoniae in sera from subjects with defects in the classical complement pathway
    Jose Yuste
    Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University St, London WC1E 6JJ, United Kingdom
    Infect Immun 76:3761-70. 2008
    ..These data confirm that the classical pathway is vital for complement-mediated phagocytosis of S. pneumoniae and demonstrate why subjects with a C2 deficiency have a marked increase in susceptibility to S. pneumoniae infections...
  37. ncbi Borrelia lonestari infection after a bite by an Amblyomma americanum tick
    A M James
    Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522-2087, USA
    J Infect Dis 183:1810-4. 2001
    ..DNA amplification of the flagellin gene flaB produced B. lonestari sequences from the skin of the patient that were identical to those found in the attached tick. B. lonestari is a probable cause of erythema migrans in humans...
  38. ncbi Resurgence of field fever in a temperate country: an epidemic of leptospirosis among seasonal strawberry harvesters in Germany in 2007
    Sarika Desai
    Department for Infectious Disease Epidemiology, Robert Koch Institute, Free University, Veterinary Faculty, Berlin, Germany
    Clin Infect Dis 48:691-7. 2009
    ..An investigation was initiated to identify the outbreak source and the risk factors for infection...
  39. ncbi Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever
    Christopher D Paddock
    Infectious Diseases Pathology Branch, Mailstop G 32, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Clin Infect Dis 47:1188-96. 2008
    ..parkeri and comment on distinctions between R. parkeri rickettsiosis and other United States rickettsioses...
  40. ncbi Q fever in humans and animals in the United States
    Jennifer H McQuiston
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Vector Borne Zoonotic Dis 2:179-91. 2002
    ....
  41. ncbi Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease
    M S Klempner
    New England Medical Center and Tufts University School of Medicine, Boston, MA, USA
    N Engl J Med 345:85-92. 2001
    ..It is controversial whether prolonged antibiotic treatment is effective for patients in whom symptoms persist after the recommended antibiotic treatment for acute Lyme disease...
  42. pmc Genetic and biochemical characterization of glycerol uptake in mycoplasma mycoides subsp. mycoides SC: its impact on H(2)O(2) production and virulence
    E M Vilei
    Institute for Veterinary Bacteriology, University of Berne, CH 3012 Berne, Switzerland
    Clin Diagn Lab Immunol 8:85-92. 2001
    ..M. mycoides subsp. mycoides SC might have adopted, as a strategy for virulence, a highly efficient uptake system for glycerol which allows the production of an active metabolic intermediate that damages host cells...
  43. ncbi Immunologic diagnosis of tuberculosis
    M L Gennaro
    Public Health Research Institute, New York, NY 10016, USA
    Clin Infect Dis 30:S243-6. 2000
    ..tuberculosis...
  44. ncbi Prospective study of pathogen burden and risk of myocardial infarction or death
    J Zhu
    Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA
    Circulation 103:45-51. 2001
    ..CONCLUSIONS: The results suggest that infection plays an important role in incident MI or death and that the risk posed by infection is independently related to the pathogen burden...
  45. pmc Serological basis for use of meningococcal serogroup C conjugate vaccines in the United Kingdom: reevaluation of correlates of protection
    R Borrow
    PHLS Meningococcal Reference Unit, Withington Hospital, Manchester M20 2LR, London NW9 5EQ, United Kingdom
    Infect Immun 69:1568-73. 2001
    ..These results indicated that the majority of toddlers with an rSBA titer between 8 and 64, and some of those with an hSBA result of <4, have mounted a protective immune response with the induction of immunological memory...
  46. ncbi Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92
    C E Cameron
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Infect Dis 181:1401-13. 2000
    ..pallidum challenge. These results demonstrate that Tp92 is an invariant, immunoprotective antigen that may be present on the surface of T. pallidum and may represent a potential vaccine candidate for syphilis...
  47. pmc Antibody profiles characteristic of Mycobacterium tuberculosis infection state
    Amy Davidow
    University of Medicine and Dentistry of New Jersey, Newark, USA
    Infect Immun 73:6846-51. 2005
    ..tuberculosis antigens varied during infection. Together, the data indicate that antigen composition of tubercle bacilli varies with stage of infection and that immunoprofiling can distinguish between tuberculosis states...
  48. ncbi Facing the crisis: improving the diagnosis of tuberculosis in the HIV era
    Mark D Perkins
    Foundation for Innovative New Diagnostics, Geneva, Switzerland
    J Infect Dis 196:S15-27. 2007
    ..In this article, we will define the need for better TB tests and describe technologies being developed to meet that need...
  49. pmc Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins
    M Collin
    Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Lund, Sweden
    Infect Immun 69:7187-9. 2001
    ..We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG...
  50. ncbi Immunogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) when coadministered with different neisseria meningitidis serogroup C conjugate vaccines
    Jacek Wysocki
    University School of Medical Sciences and Regional Medical Center for Mother and Child, Poznan, Poland
    Pediatr Infect Dis J 28:S77-88. 2009
    ....
  51. ncbi Genetic variation and heritability of the antibody response to Mycobacterium avium subspecies paratuberculosis in Danish Holstein cows
    H Mortensen
    Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Denmark
    J Dairy Sci 87:2108-13. 2004
    ..e., heavy bacterial shedders may have been represented among the cows sampled. It does not appear that intrauterine transmission is of major importance in the transmission of paratuberculosis...
  52. pmc High prevalence of natural Chlamydophila species infection in calves
    JunBae Jee
    Department of Pathobiology, College of Veterinary Medicine, Auburn University, 270 Greene Hall, Auburn, AL 36849 5519, USA
    J Clin Microbiol 42:5664-72. 2004
    ..02). Collectively, crowding strongly enhances the frequency and intensity of highly prevalent Chlamydophila infections in cattle...
  53. pmc Leptospirosis in a subsistence farming community in Brazil
    Henio G Lacerda
    Department of Infectious Diseases, Universidade Federal do Rio Grande do Norte, CP 1624, Natal, RN, 59078 970, Brazil
    Trans R Soc Trop Med Hyg 102:1233-8. 2008
    ..Additional studies are needed to characterize the mode of transmission in this region...
  54. ncbi Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans
    J K Ma
    Department of Immunology, United Medical and Dental Schools, Guy s Hospital, London, UK
    Nat Med 4:601-6. 1998
    ..These findings could be extended to the immunotherapeutic prevention of other mucosal infections in humans and animals...
  55. ncbi The success and failure of BCG - implications for a novel tuberculosis vaccine
    Peter Andersen
    Statens Serum Institute, Department of Infectious Disease Immunology, Artillerivej 5, 2300 Copenhagen S, Denmark
    Nat Rev Microbiol 3:656-62. 2005
    ..Here, we discuss the potential mechanisms behind the variation of BCG efficacy and their implications for an improved TB vaccination strategy...
  56. pmc IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G
    Ulrich von Pawel-Rammingen
    Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, BMC, B14, SE 221 84 Lund, Sweden
    EMBO J 21:1607-15. 2002
    ..pyogenes by phagocytic cells. This and additional observations on the distribution and expression of the ideS gene indicate that IdeS represents a novel and significant bacterial virulence determinant, and a potential therapeutic target...
  57. pmc In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity
    Herman F Staats
    Department of Pathology, Box 3712, DUMC, Durham, NC 27710, USA
    Infect Immun 75:5443-52. 2007
    ..Thus, this LeTx neutralization assay may be a more biologically relevant neutralization assay to predict the in vivo protective capacity of LeTx-neutralizing antibodies...
  58. pmc Immune responses to defined antigens of Mycobacterium bovis in cattle experimentally infected with Mycobacterium kansasii
    W R Waters
    United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, P O Box 70, Ames, IA 50010 0070, USA
    Clin Vaccine Immunol 13:611-9. 2006
    ..bovis infection. These findings indicate that M. kansasii infection of calves elicits specific responses that may confound the interpretation of bovine tuberculosis tests...
  59. pmc Search for correlates of protective immunity conferred by anthrax vaccine
    S Reuveny
    Department of Biotechnology, Israel Institute for Biological Research, Ness-Ziona 74100, Israel
    Infect Immun 69:2888-93. 2001
    ....
  60. ncbi Prevalence of Chlamydiaceae and Mollicutes on the genital mucosa and serological findings in dairy cattle
    Tom Petit
    Clinic for Obstetrics, Gynaecology and Andrology, University of Veterinary Sciences, 1210 Vienna, Austria
    Vet Microbiol 127:325-33. 2008
    ..diversum existed in 12% of cervical and 36% of vaginal swabs and was found in 8 out of 17 animals with vaginitis. Out of the animals tested, 44.9% were seropositive for Chlamydiaceae, 14.8% for M. bovis and 27.3% for M. bovigenitalium...
  61. ncbi Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood
    Hoda M Malaty
    Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
    Lancet 359:931-5. 2002
    ..Helicobacter pylori infection is common worldwide, but the time of acquisition is unclear. We investigated this issue in a cohort of children selected retrospectively from a population followed up for 21 years...
  62. ncbi Immunogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) compared to the licensed 7vCRM vaccine
    Timo Vesikari
    Vaccine Research Center, University of Tampere Medical School, Tampere, Finland
    Pediatr Infect Dis J 28:S66-76. 2009
    ..The immunogenicity of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) was assessed and compared with the 7-valent pneumococcal conjugate vaccine (7vCRM)...
  63. ncbi Vaccine-induced protection against gastrointestinal bacterial infections in the absence of secretory antibodies
    Tania K Uren
    The CRC for Vaccine Technology, The University of Melbourne, Department of Microbiology and Immunology, Melbourne, Victoria 3010, Australia
    Eur J Immunol 35:180-8. 2005
    ..rodentium, but is not essential for protection against re-infection with S. typhimurium or C. rodentium...
  64. pmc Humoral and cell-mediated adaptive immune responses are required for protection against Burkholderia pseudomallei challenge and bacterial clearance postinfection
    Gareth D Healey
    Host Pathogen Analysis, Bldg 7A, Rm 201, Dstl, Porton Down, Salisbury SP4 0JQ, United Kingdom
    Infect Immun 73:5945-51. 2005
    ..These results indicate the importance of both cell-mediated and humoral immune mechanisms in protection against intracellular pathogens...
  65. ncbi Multiple infections and subsequent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study
    Marek Smieja
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Circulation 107:251-7. 2003
    ....
  66. pmc Early induction of humoral and cellular immune responses during experimental Mycobacterium avium subsp. paratuberculosis infection of calves
    W R Waters
    Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa 50010, USA
    Infect Immun 71:5130-8. 2003
    ..Additionally, this study confirms that mycobacteria-specific antibody is detectable early in the course of experimental Johne's disease, even preceding the development of specific cell-mediated responses...
  67. ncbi Comparison of carboxylated and Penta-His microspheres for semi-quantitative measurement of antibody responses to His-tagged proteins
    Nelianne Verkaik
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    J Immunol Methods 335:121-5. 2008
    ..Therefore, we conclude that for developing a multiplex assay for semi-quantitative measurement of antibody responses against His-tagged proteins the best microspheres to use are the carboxylated ones...
  68. pmc Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS Med 2:e15. 2005
    ....
  69. ncbi A newly identified protein of Leptospira interrogans mediates binding to laminin
    Mariana T Longhi
    Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil 1500, 05503 900 Sao Paulo, SP, Brazil
    J Med Microbiol 58:1275-82. 2009
    ..Taken together, these data indicate that this newly identified membrane protein is expressed during natural infection and may play a role in mediating adhesion of L. interrogans to its host...
  70. pmc Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization
    Tera L McCool
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
    Infect Immun 72:5807-13. 2004
    ..These results demonstrate that antibody is not required for clearance of pneumococcal colonization in mice...
  71. ncbi Serological characterisation of anti-endotoxin sera directed against the conjugates of oligosaccharide core of Escherichia coli type R1, R2, R3, J5 and Salmonella Ra with tetanus toxoid
    C Lugowski
    Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Wrocław, Poland
    FEMS Immunol Med Microbiol 16:21-30. 1996
    ..These reactions were shown in both the ELISA assay and the immunoblotting test...
  72. pmc Increasing the interaction of Borrelia burgdorferi with decorin significantly reduces the 50 percent infectious dose and severely impairs dissemination
    Qilong Xu
    Department of Pathobiological Sciences, Louisiana State University, Skip Bertman Drive at River Road, Baton Rouge, LA 70803, USA
    Infect Immun 75:4272-81. 2007
    ..Taken together, the study highlights the importance of controlling surface antigen expression in the infectivity, dissemination, tissue colonization, pathogenicity, and persistence of B. burgdorferi during mammalian infection...
  73. ncbi [Leptospiral infection and subclinical presentation among children in Salvador, Bahia]
    Hagamenon R Silva
    Centro de Estudos de Infectologia Pediátrica, Hospital Couto Maia, Secretaria de Saude do Estado da Bahia, Brasil
    Rev Soc Bras Med Trop 36:227-33. 2003
    ..In conclusion, leptospiral infection in children (from 2 to 15 years of age) in Salvador is underestimated, because it is asymptomatic or presents as a cold syndrome simile...
  74. pmc Laboratory findings in cows after experimental infection with Ehrlichia phagocytophila
    N Pusterla
    Department of Veterinary Internal Medicine, University of Zurich, Switzerland
    Clin Diagn Lab Immunol 4:643-7. 1997
    ..E. phagocytophila DNA was detected in blood samples by nested PCR from 1 to 2 days before to 2 to 12 days after the organisms were identified microscopically. In milk samples, E. phagocytophila DNA was detected for an average of 11 days...
  75. ncbi Leptospiral infection: a household serosurvey in urban and rural communities in Barbados and Trinidad
    C O Everard
    Leptospira Laboratory, St Michael, Barbados
    Ann Trop Med Parasitol 84:255-66. 1990
    ..Lack of an inside toilet was associated with an increase in seropositivity on both islands. There was little evidence of household clustering of seropositive cases...
  76. ncbi Anthrax capsule vaccine protects against experimental infection
    Donald J Chabot
    US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21701, USA
    Vaccine 23:43-7. 2004
    ..Surprisingly, some protection was also observed when protective antigen was conjugated to itself...
  77. ncbi Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis
    Michelle Nelson
    Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
    J Med Microbiol 53:1177-82. 2004
    ..This study is the first time antigens protective by active immunization have been identified and suggests that polysaccharides have potential as vaccine candidates against melioidosis...
  78. ncbi Protective immunization against inhalational anthrax: a comparison of minimally invasive delivery platforms
    John A Mikszta
    BD Technologies, 21 Davis Dr, Research Triangle Park, NC 27709, USA
    J Infect Dis 191:278-88. 2005
    ..The novel vaccine/device combinations described here have the potential to improve the efficacy of rPA and other biodefense vaccines...
  79. pmc Discovery of a new capsular serotype (6C) within serogroup 6 of Streptococcus pneumoniae
    In Ho Park
    Department of Pathology, University of Alabama at Birmingham, 845 19th Street South BBRB 614, Birmingham, AL 35294, USA
    J Clin Microbiol 45:1225-33. 2007
    ..This study also demonstrates that a new serotype may exist within an established and well-characterized serogroup or serotype...
  80. ncbi Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice
    Ricky L Ulrich
    Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA
    Vaccine 23:1986-92. 2005
    ..Thus, live attenuated strains that promote a Th1-like Ig response may serve as promising vaccine candidates against aerosol infection with B. mallei...
  81. pmc Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production
    Ashlesh K Murthy
    Department of Biology, University of Texas at San Antonio, 6900N Loop 1604W, San Antonio, TX 78249, USA
    Infect Immun 75:666-76. 2007
    ..Together, these results demonstrate that secreted chlamydial antigens may be novel vaccine candidates to induce protective immunity...
  82. ncbi Naturally-acquired immunity to Neisseria meningitidis group A
    Jacob Amir
    Schneider Children s Medical Center of Israel, Petach Tikva, Israel
    Vaccine 23:977-83. 2005
    ..Cross-reacting group A anticapsular antibodies are prevalent in North American and Ugandan sera, but bactericidal activity is infrequent and when present is largely directed at non-capsular antigens...
  83. pmc Complement activation and formation of the membrane attack complex on serogroup B Neisseria meningitidis in the presence or absence of serum bactericidal activity
    M Drogari-Apiranthitou
    Department of Medical Microbiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Infect Immun 70:3752-8. 2002
    ..These findings support the hypothesis that proper MAC insertion rather than the quantity of MAC formed on the bacterial surface is of importance for efficient lysis of meningococci...
  84. ncbi Bacterial determinants of persistent throat colonization and the associated immune response in a primate model of human group A streptococcal pharyngeal infection
    C D Ashbaugh
    Channing Laboratory, Boston, MA 02115, USA
    Cell Microbiol 2:283-92. 2000
    ....
  85. ncbi Evaluation of a commercial ELISA for diagnosis of paratuberculosis in cattle
    D A Dargatz
    USDA:APHIS Centers for Epidemiology and Animal Health, Fort Collins, CO 80521, USA
    J Am Vet Med Assoc 218:1163-6. 2001
    ..Practitioners must be aware of variability in the sensitivity of the test, which depends on the clinical and shedding status of the cattle, because this may affect interpretation of test results...
  86. ncbi A community-based seroepidemiologic study of Helicobacter pylori infection in Mexico
    J Torres
    Unidad de Investigación Médica en Enfermedades Infecciosas, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    J Infect Dis 178:1089-94. 1998
    ..42), and low socioeconomic level (OR, 1.43) were risk factors for infection. Prevalence was similar in urban and in rural communities (OR, 0.95). This study is the largest community-based seroepidemiologic study of H. pylori to date...
  87. pmc Evaluation of five antibody detection tests for diagnosis of bovine paratuberculosis
    Michael T Collins
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Dr, Madison, WI 53706 1102, USA
    Clin Diagn Lab Immunol 12:685-92. 2005
    ..paratuberculosis in its feces. If used judiciously and interpreted quantitatively, these ELISAs are useful tools in support of paratuberculosis control programs in dairy herds...
  88. ncbi Concentration of antipneumococcal antibodies as a serological correlate of protection: an application to acute otitis media
    Jukka T Jokinen
    Department of Vaccines, National Public Health Institute, Helsinki, Finland
    J Infect Dis 190:545-50. 2004
    ..However, the serological correlates of protection have not been established for pneumococcal diseases...
  89. ncbi Seroprevalence of meningococcal serogroup C bactericidal antibody in England and Wales in the pre-vaccination era
    Caroline Trotter
    Immunisation Division, PHLS Communicable Disease Surveillance Centre, 61 Colindale Avenue, London NW9 5EQ, UK
    Vaccine 21:1094-8. 2003
    ..This study provides baseline antibody levels which will facilitate the evaluation of the meningococcal serogroup C conjugate vaccination programme...
  90. pmc Dogs as sentinels for human Lyme borreliosis in The Netherlands
    H A Goossens
    Department of Medical Microbiology, University of Maastricht, NL-6200 MD Maastricht, The Netherlands
    J Clin Microbiol 39:844-8. 2001
    ....
  91. ncbi Effects of a challenge dose of Salmonella Typhimurium or Salmonella Yoruba on the patterns of excretion and antibody responses of pigs
    J Osterberg
    National Veterinary Institute, Uppsala, Sweden
    Vet Rec 162:580-6. 2008
    ..65 x 10(6) cfu seroconverted later and with lower titres of antibodies, and the pigs inoculated with 0.65 x 10(3) cfu did not seroconvert. A similar pattern was observed with S Yoruba, but the responses were slower and at lower titres...
  92. pmc Development of an improved vaccine for anthrax
    Stephen H Leppla
    National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892 4350, USA
    J Clin Invest 110:141-4. 2002
  93. ncbi Genus and species-specific IgG and IgM antibodies for pulmonary tuberculosis
    Tariq Butt
    Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi
    J Coll Physicians Surg Pak 14:105-7. 2004
    ..To evaluate three different enzyme immunoassays for serological diagnosis of pulmonary tuberculosis and to compare their diagnostic accuracy in different combinations...
  94. pmc Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence
    Case McNamara
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
    Science 319:1405-8. 2008
    ..Idealized M proteins appear to have promise as vaccine immunogens...
  95. ncbi Bactericidal monoclonal antibodies that define unique meningococcal B polysaccharide epitopes that do not cross-react with human polysialic acid
    D M Granoff
    Chiron Vaccines, Emeryville, CA 94608, USA
    J Immunol 160:5028-36. 1998
    ..These Abs may be useful for the identification of molecular mimetics capable of eliciting protective Abs specific to the bacteria, without the risk of evoking autoimmune disease...
  96. pmc Functional analysis of Bacillus anthracis protective antigen by using neutralizing monoclonal antibodies
    Fabien Brossier
    Unité Toxines et Pathogénie Bactériennes, URA 2172, CNRS, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Infect Immun 72:6313-7. 2004
    ..This work contributes to the functional analysis of PA and offers immunotherapeutic perspectives for the treatment of anthrax disease...
  97. ncbi Oral vaccination of mice against tetanus with recombinant Lactococcus lactis
    K Robinson
    Department of Pathology, University of Cambridge, UK
    Nat Biotechnol 15:653-7. 1997
    ..Chemically killed lactococci administered via the intranasal route were also able to elicit serum antibody responses of similar levels and kinetics to those induced by live bacteria...
  98. pmc Molecular detection of Coxiella burnetii in the sera of patients with Q fever endocarditis or vascular infection
    F Fenollar
    Unite des Rickettsies, IFR 48 CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    J Clin Microbiol 42:4919-24. 2004
    ..004). In patient samples with titers below 1:25,600 tested prospectively, sensitivity was 100% (7 of 7). The LCN-PCR assay may be helpful in establishing an early diagnosis of chronic Q fever...
  99. ncbi Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity
    Jennifer A Maynard
    Department of Chemical Engineering, University of Texas, Austin, TX 78712, USA
    Nat Biotechnol 20:597-601. 2002
    ..High-affinity toxin-neutralizing antibodies may be of therapeutic value for alleviating the symptoms of anthrax toxin in infected individuals and for medium-term prophylaxis to infection...
  100. pmc Changing epidemiology of Q fever in Germany, 1947-1999
    W Hellenbrand
    Robert Koch Institut, Berlin, Germany
    Emerg Infect Dis 7:789-96. 2001
    ..The location of recent outbreaks suggests that urbanization of rural areas may be contributing to the increase in Q fever. Prevention efforts should focus on reducing sheep-related exposures, particularly near urban areas...
  101. pmc Kinetics of antibody responses in Rickettsia africae and Rickettsia conorii infections
    Pierre Edouard Fournier
    Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
    Clin Diagn Lab Immunol 9:324-8. 2002
    ..We recommend that sera collected 4 weeks after the onset of signs of patients with suspected African tick-bite fever should be used for the definitive serological diagnosis of R. africae infections...

Research Grants69

  1. Autonomic dysreflexia and SCI immune suppression
    Phillip G Popovich; Fiscal Year: 2010
    ..subsequently immunize them with prophylactic vaccines designed to elicit production of anti-viral or anti-bacterial antibodies. Again, comparisons will be made between T3 and T9 mice...
  2. Pneumolysin, Innate and Acquired Immunity to Pneumococci
    Richard Malley; Fiscal Year: 2005
    ..The establishment of a link between the innate and the acquired arm of the immune response to pneumococcus may provide a better understanding of the mechanisms by which immunity to pneumococcus is acquired. ..
  3. Pneumococcal immunization through a novel mechanism
    Richard Malley; Fiscal Year: 2010
    ..abstract_text> ..
  4. Structural determinants of human immunity to anthrax
    Donald Reason; Fiscal Year: 2008
    ..anthracis infection. In addition, the antibodies isolated will constitute a panel of fully human monoclonal binding domains with potential for therapeutic use as passive immunogens. [unreadable] [unreadable] [unreadable]..
  5. Human monoclonal panel mimicking anthrax immune globulin
    Donald Reason; Fiscal Year: 2005
    ..The PA-specific panel we construct will be molecularly defined and characterized, incorporate the advantages of toxin-specific, polyclonal human sera, and lack the inherent risk associated with blood derived products. ..
  6. Enteric flora modulates the development of colitis
    Albert Jergens; Fiscal Year: 2008
    ..g., graduate students and postdoctoral fellow). There are ample opportunities to attend seminars, journal clubs and work-in-progress research meetings during which the applicant can become engaged in scientific discussions. ..
  7. The Role of Pesticide Dispersion Within Texas Watershed*
    James Thompson; Fiscal Year: 2004
    ..It is anticipated that the results produced will provide the preliminary data needed to continue definitive investigations under the auspices of subsequent R01 funding. ..
  8. MOLECULAR DETERMINANTS OF HUMAN PNEUMOCOCCAL IMMUNITY
    Donald Reason; Fiscal Year: 2004
    ..Understanding the molecular mechanisms that shape the human antibody repertoire to pneumococcal polysaccharides may also suggest strategies that would facilitate the development of more efficacious vaccines. ..
  9. Priming CD4+ T cells to protect against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2004
    ..Our long-term goals are to use that information to develop effective pneuinonic plague vaccines. ..
  10. Cell-mediated protection against pneumonic plague
    STEPHEN SMILEY; Fiscal Year: 2008
    ..abstract_text> ..
  11. Development of a small molecule screen for PhoP regulon inhibitors in Salmonella
    Jason Harris; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  12. Molecular basis meningococcal group A capsular immunity
    Dan Granoff; Fiscal Year: 2007
    ..abstract_text> ..
  13. Roles for coagulation in immunity
    STEPHEN SMILEY; Fiscal Year: 2005
    ..Deciphering those mechanisms may lead to improved vaccines and/or treatments for pathologies characterized by fibrin deposition, including autoimmunity, allograft rejection, cancer and septic shock. ..
  14. Development of an additive model to study the significance of heat-labile and hea
    Weiping Zhang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Pathogenesis of EAST1 toxin in ETEC associated diarrhea disease
    Weiping Zhang; Fiscal Year: 2008
    ..The determination of virulence significance of EAST1 toxin in diarrheal disease will provide essential information to prevent or control this disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  16. Neisseria meningitidis antigens expressed in infection
    Dan Granoff; Fiscal Year: 2005
    ..meningitidis disease, including group B strains for which there is currently no vaccine available. Also, characterization of gene expression in an in vivo model will lead to a better understanding of meningococcal pathogenesis. ..
  17. Topical Antibiotics to Prevent Lyme Disease
    Gary Wormser; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  18. The Joint Risks of Hazadous Air Pollulants Among Childhood Cancer Histotypes
    James Thompson; Fiscal Year: 2007
    ..This study will identify the areas of high risk and the associated HAPs exposures, information essential to elucidate the role of HAPs and to guide further study. [unreadable] [unreadable] [unreadable]..
  19. BACTERIAL MODULATION OF LUNG INFLAMMATORY RESPONSE
    Thomas Russo; Fiscal Year: 2004
    ..g. hemolysin) and bacterially induced host response elements in directly mediating the pathogenesis of lung injury. ..
  20. Exacerbation of Atherosclerosis
    Guangming Zhong; Fiscal Year: 2004
    ..pneumoniae exacerbation of atherosclerosis will be evaluated. These studies may provide the essential information on designing effective approaches for preventing and controlling C. pneumoniae-exacerbated atherosclerosis. ..
  21. Mucosal immune response to oral cholera vaccine Peru 15
    Firdausi Qadri; Fiscal Year: 2007
    ..cholerae. ..
  22. Chlamydial Manipulation of Host Apoptosis
    Guangming Zhong; Fiscal Year: 2010
    ..abstract_text> ..
  23. Zinc, Mental Health and School Performance in Mexico
    ARYEH STEIN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. Interferon gamma assay for latent TB in HIV infection
    Alamelu Raja; Fiscal Year: 2007
    ..IGRA, if found useful, will form a simple field test for application in Tuberculosis Control Program, as well as to target the HIV positive subjects for chemoprophylaxis. [unreadable] [unreadable] [unreadable]..
  25. Antigen Capture Assays for Rapid Detection of Y. Pestis
    Raymond Dattwyler; Fiscal Year: 2008
    ..The ultimate goal is to develop a highly sensitive multi-antigen rapid lateral flow (or dipstick) assay that will detect levels as low as 0.1ng/ml of Y. pestis antigen. ..
  26. Immunoepidemiology of Concomittant Infection
    Sharon Perry; Fiscal Year: 2008
    ..S. foreign born and the developing world. ..
  27. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..Cytokine genes are expressed at different levels in older compared to younger women;therefore, we will also evaluate their contribution to breast cancer risk by levels of common exposures such as obesity and HRT use. ..
  28. The actin cytoskeleton in Beta cell activation
    Wenxia Song; Fiscal Year: 2009
    ..These studies will increase our understanding of underlying mechanisms for regulation of B cell activation and enhance our ability to manipulate and control antibody responses. ..
  29. Human T Cell Antigens of Mycobacterium tuberculosis
    Steven Reed; Fiscal Year: 2009
    ..Finally, we will test antigens/vaccine formulations in rodent models of infection and disease. By the end of the funding period, we will have defined a second vaccine candidate for entry into clinical trials. ..
  30. High throughput proteomic analysis of Salmonella enterica
    Edward Ryan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  31. Parental Expression of Immune Responses In Pediatric Crohn's Disease
    Marla Dubinsky; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  32. RA Comorbidity Bone Health in Men and African Americans
    Ted Mikuls; Fiscal Year: 2008
    ..Mikuls' continued development as an independent clinical investigator. ..
  33. Nasal Vaccines: Mode of Action, Composition & Delivery
    Herman F Staats; Fiscal Year: 2010
    ..abstract_text> ..
  34. Anthrax DNA vaccine for non-invasive immunization on skin
    Zhengrong Cui; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. Respiratory Immunity Against Agents of Bioterrorism
    STEVEN MIZEL; Fiscal Year: 2008
    ....
  36. Diagnosis and Pathogenesis of Early Lyme Disease
    Allen Steere; Fiscal Year: 2007
    ..In addition, greater knowledge of spirochetal virulence and host factors associated with severe disease may allow the development of laboratory markers for patients who would benefit from more intensive treatment. ..
  37. Innate and Adaptive Immunity in Acne Vulgaris
    Jenny Kim; Fiscal Year: 2006
    ..Better understanding of the innate and adaptive immune mechanisms against P. acnes could provide insight into host defense mechanisms in skin and suggest development of novel avenues of immunologic intervention in acne. ..
  38. IBD--MUCOSA-SPECIFIC REGULATION OF IFN-GAMMA PRODUCTION
    Stephan Targan; Fiscal Year: 2005
    ..abstract_text> ..
  39. BACTERIA INDUCED CYTOKINE PRODUCTION IN THE GUT
    Gary Klimpel; Fiscal Year: 2001
    ....
  40. Therapeutic immune mechanisms of daclizumab in psoriasis
    James Krueger; Fiscal Year: 2004
    ..We will also measure the impact of daclizumab on T cell activation/deviation towards Type 2 T cells by sensitive flow cytometry based assays. ..
  41. BIOLOGY AND CONTROL OF LYME DISEASE BORRELIA
    Alan Barbour; Fiscal Year: 2004
    ..burgdorferi, its transmission, and reservoir host immunize responses. The results may also have relevance for the control of other vector-bone zoonotic diseases and perhaps for development of novel methods for vaccine delivery. ..
  42. Chlamydia trachomatis and Cervical Cancer
    MARGARET MADELEINE; Fiscal Year: 2003
    ..trachomatis may become a higher public health priority. Furthermore, our results would help determine whether further follow up of the C. trachomatis and cervical cancer association is warranted in a more expensive, prospective setting. ..
  43. TRANSCUTANEOUS IMMUNIZATION FOR TETANUS BOOSTER
    Gregory Glenn; Fiscal Year: 2003
    ..Additionally, the Transcutaneous booster will decrease the risk of needle-sticks and related disease, and reduce personnel and equipment requirements related to tetanus immunization. ..
  44. Periodontal microbiota, serum Antibody response & T1DM
    Evanthia Lalla; Fiscal Year: 2002
    ..Theses studies will markedly enhance our understanding of the oral microbiology and immunology in type 1 diabetes. ..
  45. FUNCTION OF THE B CELL ANTIGEN IN ANTIGEN PROCESSING
    Wenxia Song; Fiscal Year: 2002
    ..The results of these studies will help us to gain the ability to control antigen processing and provide the strategies for the design of effective vaccines and therapies for autoimmune diseases. ..
  46. HOST FACTORS MEDIATE INVASION BY CAMPYLOBACTER JEJUNI
    LINDA MANSFIELD; Fiscal Year: 2002
    ..jejuni invasion is facilitated due to a direct effect of some secreted/excreted product of the worms, and 4) Determine what host cell genes are differentially expressed during C. jejuni invasion. ..
  47. C3d-PA: efficacy & cellular basis as an anthrax vaccine
    ROBERT RICKERT; Fiscal Year: 2005
    ..Pending completion of the proposed work outlined in this R21 application, a series of experiments involving anthrax challenge models would seem appropriate. ..
  48. Modulation of B-cell tolerance by coreceptor molecules
    ROBERT RICKERT; Fiscal Year: 2005
    ....
  49. Infection Dynamics of Ehrlichia chaffeensis
    Andrea Varela Stokes; Fiscal Year: 2006
    ..Varela to develop into an outstanding medical parasitologist and add to the understanding of tick-borne disease and human health. ..
  50. Development of a New Tularemia Vaccine
    Mingtao Zeng; Fiscal Year: 2006
    ..Since no previous research has shown that genetic immunization with adenovirus or plasmid vectors could elicit protective immunity to F. tularensis, the proposed project is exploratory and developmental in nature. ..
  51. Oral Pathogens: Polymicrobial Virulence Interactions
    KESAVALU LAKSHMYYA; Fiscal Year: 2006
    ..Consequently, the host response to these chronic infections must be considered as critical to general health. ..
  52. Mucosal Immunity to Antigens Expressed by V.cholerae
    Edward Ryan; Fiscal Year: 2006
    ..difficile toxin A is injected into ligated ileal loops of vaccinated and control animals. ..
  53. Gammacell-220 Excel Refurbished Research Irradiator
    David Walker; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. Protective Immune Responses in HIV-1 Exposed Infants
    Carey Farquhar; Fiscal Year: 2006
    ..Kreiss and John, will prepare her for the complex data analysis required by this study and contribute substantially to the development of her career as an independent clinical investigator. ..
  55. Preclinical Development of Non-Invasive Anthrax Vaccine
    SUSAN WIMER; Fiscal Year: 2005
    ....
  56. CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGY
    Harvey Risch; Fiscal Year: 2002
    ....
  57. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen H Gregory; Fiscal Year: 2010
    ..Consequently, they should provide valuable insights that enable the development of innovative strategies to improve treatment and prevent the devastating consequencesoften associated with septicemia and sepsis. ..
  58. Genetic Determinants of Anaplasma Transmission
    SUSAN NOH; Fiscal Year: 2004
    ..The sponsor has an active research program in vector borne disease has successfully mentored clinicians, graduate students, and post-doctoral fellows to research independence. ..
  59. Immune response to Helicobacter pylori VacA as a marker
    Guillermo Perez Perez; Fiscal Year: 2004
    ..If our hypothesis is correct, we hope to establish a simple and economical serological test to assess the risk of gastric cancer development. ..
  60. Case-Control Study of Pancreas Cancer Etiologic Factors
    Harvey Risch; Fiscal Year: 2008
    ..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. [unreadable] [unreadable]..
  61. FRANCISELLA TULARENSIS: INNATE RESISTANCE TO IHALATION
    Stephen Gregory; Fiscal Year: 2004
    ..abstract_text> ..
  62. Host response to Chlamydia genital infection in the male
    Roger Rank; Fiscal Year: 2008
    ..abstract_text> ..
  63. Mobilization of Candida albicans Biofilms
    Peter Suci; Fiscal Year: 2007
    ..albicans biofilm communities, it will provide the basis for development of methods for screening for adjuvant agents that will inhibit dissemination of these fungal infections. [unreadable] [unreadable] [unreadable]..
  64. DNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDY
    Harvey Risch; Fiscal Year: 2002
    ..abstract_text> ..
  65. Gamma-Delta T cells and Cryptosporidiosis
    Beth Kirkpatrick; Fiscal Year: 2008
    ..These data will advance our understanding of the mucosal immune response to cryptosporidiosis, which will lead to further advances in prevention and therapy. ..
  66. VP22 TRAFFICKING FOR MAXIMAL GENE THERAPY
    Gary Splitter; Fiscal Year: 2004
    ..This construct will be compared to vector-tk only by testing in vitro. (b) We will also evaluate the efficacy of VP22-tk chimeric polypeptides in vivo tumor killing in the presence of ganciclovir. ..
  67. Development of Genetic Tools for Clostridium botulinum
    Eric Johnson; Fiscal Year: 2005
    ..abstract_text> ..
  68. Vaccine efficacy post related and unrelated HCT
    Trudy Small; Fiscal Year: 2004
    ..abstract_text> ..