- A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells
Institute of Child Health, University of Birmingham, Birmingham B16 8ET, UK
EMBO J 17:2166-76. 1998
- Anti-staphylococcal humoral immune response in persistent nasal carriers and noncarriers of Staphylococcus aureus
Nelianne J Verkaik
Departments of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
J Infect Dis 199:625-32. 2009
..Persistent carriers have a higher risk of Staphylococcus aureus infections than noncarriers but a lower risk of bacteremia-related death. Here, the role played by anti-staphylococcal antibodies was studied...
- Herd-level economic losses associated with Johne's disease on US dairy operations
S L Ott
Center for Epidemiology, US Department of Agriculture, Fort Collins, CO 80521, USA
Prev Vet Med 40:179-92. 1999
..Averaged across all herds, Johne's disease costs the US dairy industry, in reduced productivity, US$ 22 to US$ 27 per cow or US$ 200 to US$ 250 million annually...
- Reclassification of Staphylococcus aureus nasal carriage types
Alex van Belkum
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
J Infect Dis 199:1820-6. 2009
..This study was performed to provide additional insight into staphylococcal carriage types...
- Efficacy of a pneumococcal conjugate vaccine against acute otitis media
National Public Health Institute, Helsinki, Finland
N Engl J Med 344:403-9. 2001
..CONCLUSIONS: The heptavalent pneumococcal polysaccharide-CRM197 conjugate vaccine is safe and efficacious in the prevention of acute otitis media caused by the serotypes included in the vaccine...
- The hypothetical protein CT813 is localized in the Chlamydia trachomatis inclusion membrane and is immunogenic in women urogenitally infected with C. trachomatis
Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
Infect Immun 74:4826-40. 2006
..Thus, the CT813 protein may represent an important candidate for understanding C. trachomatis pathogenesis and developing intervention and prevention strategies for controlling C. trachomatis infection...
- Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice
Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA
Infect Immun 65:1993-9. 1997
..Therefore, these data suggest that both humoral and cell-mediated immune responses were important mediators of immune protection in this model, though cell-mediated immune responses appear to play a more dominant role...
- Meningococcal surrogates of protection--serum bactericidal antibody activity
Meningococcal Reference Unit, Health Protection Agency North West Laboratory, Manchester Royal Infirmary, Manchester M13 9WZ, UK
Vaccine 23:2222-7. 2005
..SBA activity as a correlate of protection for evaluating the immune response to meningococcal vaccines is described in this review...
- Household transmission of leptospira infection in urban slum communities
Elves A P Maciel
Centro de Pesquisas Goncalo Moniz, Fundacao Oswaldo Cruz, Ministerio da Saude, Salvador, Bahia, Brazil
PLoS Negl Trop Dis 2:e154. 2008
..However, slum inhabitants reside in close proximity to environmental sources of contamination, suggesting that transmission during urban epidemics occurs in the household environment...
- Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants
Department of Vaccines and Biologicals, World Health Organization, CH 1211 27, Geneva, Switzerland
Vaccine 21:3265-72. 2003
..More detailed recommendations for production and control of pneumococcal conjugate vaccines, including criteria for evaluation for licensure, are currently being drafted...
- Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriage
Simon R Clarke
Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom
J Infect Dis 193:1098-108. 2006
..aureus to human desquamated nasal epithelial cells and is required for nasal colonization in the cotton rat model. Thus, vaccination with these antigens may prevent S. aureus carriage and reduce the prevalence of human disease...
- Antibody-mediated disease remission in the mouse model of lyme borreliosis
Stephen W Barthold
Center for Comparative Medicine, School of Medicine, University of California at Davis, One Shields Avenue, Davis, California 95616, USA
Infect Immun 74:4817-25. 2006
..These results suggest that Arp and DbpA antibodies may be active as disease-resolving components in immune serum but antibody against other antigens may be involved in reductions of spirochetes in tissues...
- Development of antibodies to Burkholderia pseudomallei during childhood in melioidosis-endemic northeast Thailand
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 74:1074-5. 2006
..There was a sharp rise in detectable antibodies from birth to 4 years followed by reactivity in approximately 60-70% of children thereafter...
- Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages
Department of Internal Medicine, Ohio State University, 420 W 12th Avenue, 216 Tzagournis Medical Research Facility, Columbus, OH 43210, USA
Infect Immun 74:5114-25. 2006
..This study demonstrates that human macrophages phagocytose more Francisella than monocytes with contributions from CR3, Fcgamma receptors, the MR, and SP-A present in lung alveoli...
- Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vector
James M Battisti
Rocky Mountain Laboratories, NIAID, NIH, 903 S 4th Street, Hamilton, MT 59840, USA
Infect Immun 76:5228-37. 2008
..We conclude that OspA serves a critical antibody-shielding role during vector blood meal uptake from immune hosts and is not required for persistence in the tick vector...
- The 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) coadministered with DTPw-HBV/Hib and poliovirus vaccines: assessment of immunogenicity
Research Institute for Tropical Medicine, Filinvest Corporate City, Alabang, Muntinlupa City, The Philippines
Pediatr Infect Dis J 28:S89-96. 2009
- Chlamydia trachomatis IncA is localized to the inclusion membrane and is recognized by antisera from infected humans and primates
J P Bannantine
Department of Microbiology, Oregon State University, Corvallis, Oregon 97331 3804, USA
Infect Immun 66:6017-21. 1998
..psittaci IncA and is also localized to the inclusion membrane. Immunoblot analysis demonstrated that sera from C. trachomatis-infected patients and from experimentally infected monkeys both recognized C. trachomatis IncA...
- Leptospira and leptospirosis
Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Australia
Vet Microbiol 140:287-96. 2010
..However, the recent development of defined mutagenesis systems for Leptospira heralds the potential for gaining a much improved understanding of pathogenesis in leptospirosis...
- Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax
Mark T Albrecht
Biological Defense Research Directorate, Naval Medical Research Center, 12300 Washington Ave, Silver Spring, MD 20910 7500, USA
Infect Immun 75:5425-33. 2007
..Based on these results, IQNPA and IQNLF act independently during prophylactic anthrax treatment and do not interfere with the establishment of endogenous immunity...
- A double-blind randomized placebo-controlled phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patients
Institute of Medical Microbiology and Hygiene, Wilhelmstrasse 31, D 72074 Tubingen, Germany
Proc Natl Acad Sci U S A 104:11020-5. 2007
..Active immunization of patients with cystic fibrosis lowers the risk for infection with P. aeruginosa and therefore may contribute to a longer survival of these patients...
- Commercial serological antibody detection tests for the diagnosis of pulmonary tuberculosis: a systematic review
Karen R Steingart
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California, San Francisco, California, United States of America
PLoS Med 4:e202. 2007
..Currently, dozens of distinct commercial antibody detection tests are sold in developing countries. The question is "do they work?"..
- Binding of human C4BP to the hypervariable region of M protein: a molecular mechanism of phagocytosis resistance in Streptococcus pyogenes
Department of Medical Microbiology, Dermatology and Infection, Lund University, Solvegatan 23, SE 223 62 Lund, Sweden
Mol Microbiol 42:539-51. 2001
..This study provides the first molecular insight into the mechanisms by which the HVR of an M protein confers phagocytosis resistance...
- Prevalence of antibodies against Mycobacterium avium subsp paratuberculosis among beef cow-calf herds
D A Dargatz
USDA Animal and Plant Health Inspection Service, Centers for Epidemiology and Animal Health, Ft Collins, CO 80521, USA
J Am Vet Med Assoc 219:497-501. 2001
..CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that the prevalence of antibodies to M avium subsp paratuberculosis among beef cows in the United States is low. Herds with seropositive animals were widely distributed geographically...
- Transitions in immune responses to Mycobacterium paratuberculosis
J R Stabel
USDA ARS, National Animal Disease Center, Ames, IA 50010, USA
Vet Microbiol 77:465-73. 2000
..This paper reviews the current knowledge of T cell immune responses in M. paratuberculosis infection based upon clinical studies and research using mouse models...
- Albendazole treatment of children with ascariasis enhances the vibriocidal antibody response to the live attenuated oral cholera vaccine CVD 103-HgR
P J Cooper
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
J Infect Dis 182:1199-206. 2000
..lumbricoides infections impair the immune response to oral cholera vaccine, particularly in subjects of non-O blood groups...
- Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon- gamma
Craig R Cohen
Department of Obstetrics, Gynecology, and Reproductive Science, University of California, San Francisco, San Francisco, California 94105, USA
J Infect Dis 192:591-9. 2005
..This investigation supports a direct role for C. trachomatis-specific immune responses in altering the risk of infection and suggests immune correlates of protection that are potentially useful in vaccine development...
- Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
Stephan R Targan
Cedars Sinai Inflammatory Bowel Disease Center, Los Angeles, California 90048, USA
Gastroenterology 128:2020-8. 2005
- Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses
Fang Ting Liang
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8031, USA
Infect Immun 72:5759-67. 2004
..This change in antigenic expression could be induced by passively immunizing infected severe combined immunodeficiency mice with specific Borrelia antisera or OspC antibody and appears to allow B. burgdorferi to resist immune attack...
- Invasive group A streptococcal infections: T1M1 isolates expressing pyrogenic exotoxins A and B in combination with selective lack of toxin-neutralizing antibodies are associated with increased risk of streptococcal toxic shock syndrome
B K Eriksson
Division of Infectious Diseases, Department of Immunology, Karolinska Institute, Huddinge University Hospital, Sweden
J Infect Dis 180:410-8. 1999
..Neutralization of SpeB was significantly lower in sera of patients with STSS than in sera from persons with bacteremia or erysipelas...
- Differences in the avidity of antibodies evoked by four different pneumococcal conjugate vaccines in early childhood
Department of Vaccines, National Public Health Institute, Helsinki, Finland
Vaccine 17:1970-7. 1999
..No vaccine specific differences were found in avidity of anti-14 or -19F antibodies. By contrast, antibody avidity to 6B and 23F differed significantly between the vaccine groups, PncCRM and PncT inducing antibodies of highest avidity...
- Experimental Corynebacterium pseudotuberculosis primary infection in goats: kinetics of IgG and interferon-gamma production, IgG avidity and antigen recognition by Western blotting
B J A Paule
Laboratorio de Imunologia, Instituto de Ciências da Saúde, Universidade Federal da Bahia, Av Reitor Miguel Calmon, S N Vale do Canela, CEP 40140 100, Salvador BA, Brazil
Vet Immunol Immunopathol 96:129-39. 2003
..Both humoral and cellular responses kinetics presented a similar pattern of activation/deactivation but necropsy results suggested that the IFN-gamma test would be a very specific marker of CLA status...
- A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection
Sandra G Morrison
Division of Infectious Diseases, Department of Medicine, University of Alabama, Birmingham 35294 0007, USA
J Immunol 175:7536-42. 2005
..These results impact our understanding of immunity to chlamydial genital infection and may provide important insight into vaccine development...
- MyD88 plays a unique role in host defense but not arthritis development in Lyme disease
Devin D Bolz
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
J Immunol 173:2003-10. 2004
..The findings presented here point to a dichotomy between the recruitment of inflammatory cells to tissue and an inability of these cells to kill localized spirochetes...
- Early antibody responses to experimental Mycobacterium bovis infection of cattle
W R Waters
Bacterial Diseases of Livestock Research Unit, Agricultural Research Service, National Animal Disease Center, United States Department of Agriculture, P O Box 70, Ames, IA 50010 0070, USA
Clin Vaccine Immunol 13:648-54. 2006
..These findings demonstrate the potential for new-generation antibody-based tests for the early detection of M. bovis infection in cattle...
- Fine and domain-level epitope mapping of botulinum neurotoxin type A neutralizing antibodies by yeast surface display
Department of Anesthesia and Pharmaceutical Chemistry, University of California, San Francisco, San Francisco General Hospital, CA 94110, USA
J Mol Biol 365:196-210. 2007
..The results demonstrate how yeast display can be used for domain-level and fine mapping of conformational BoNT antibody epitopes and the mapping results identify three neutralizing BoNT/A epitopes...
- Impaired opsonization with C3b and phagocytosis of Streptococcus pneumoniae in sera from subjects with defects in the classical complement pathway
Centre for Respiratory Research, Department of Medicine, Royal Free and University College Medical School, Rayne Institute, 5 University St, London WC1E 6JJ, United Kingdom
Infect Immun 76:3761-70. 2008
..These data confirm that the classical pathway is vital for complement-mediated phagocytosis of S. pneumoniae and demonstrate why subjects with a C2 deficiency have a marked increase in susceptibility to S. pneumoniae infections...
- Borrelia lonestari infection after a bite by an Amblyomma americanum tick
A M James
Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522-2087, USA
J Infect Dis 183:1810-4. 2001
..DNA amplification of the flagellin gene flaB produced B. lonestari sequences from the skin of the patient that were identical to those found in the attached tick. B. lonestari is a probable cause of erythema migrans in humans...
- Resurgence of field fever in a temperate country: an epidemic of leptospirosis among seasonal strawberry harvesters in Germany in 2007
Department for Infectious Disease Epidemiology, Robert Koch Institute, Free University, Veterinary Faculty, Berlin, Germany
Clin Infect Dis 48:691-7. 2009
..An investigation was initiated to identify the outbreak source and the risk factors for infection...
- Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever
Christopher D Paddock
Infectious Diseases Pathology Branch, Mailstop G 32, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
Clin Infect Dis 47:1188-96. 2008
..parkeri and comment on distinctions between R. parkeri rickettsiosis and other United States rickettsioses...
- Q fever in humans and animals in the United States
Jennifer H McQuiston
Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Vector Borne Zoonotic Dis 2:179-91. 2002
- Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease
M S Klempner
New England Medical Center and Tufts University School of Medicine, Boston, MA, USA
N Engl J Med 345:85-92. 2001
..It is controversial whether prolonged antibiotic treatment is effective for patients in whom symptoms persist after the recommended antibiotic treatment for acute Lyme disease...
- Genetic and biochemical characterization of glycerol uptake in mycoplasma mycoides subsp. mycoides SC: its impact on H(2)O(2) production and virulence
E M Vilei
Institute for Veterinary Bacteriology, University of Berne, CH 3012 Berne, Switzerland
Clin Diagn Lab Immunol 8:85-92. 2001
..M. mycoides subsp. mycoides SC might have adopted, as a strategy for virulence, a highly efficient uptake system for glycerol which allows the production of an active metabolic intermediate that damages host cells...
- Immunologic diagnosis of tuberculosis
M L Gennaro
Public Health Research Institute, New York, NY 10016, USA
Clin Infect Dis 30:S243-6. 2000
- Prospective study of pathogen burden and risk of myocardial infarction or death
Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA
Circulation 103:45-51. 2001
..CONCLUSIONS: The results suggest that infection plays an important role in incident MI or death and that the risk posed by infection is independently related to the pathogen burden...
- Serological basis for use of meningococcal serogroup C conjugate vaccines in the United Kingdom: reevaluation of correlates of protection
PHLS Meningococcal Reference Unit, Withington Hospital, Manchester M20 2LR, London NW9 5EQ, United Kingdom
Infect Immun 69:1568-73. 2001
..These results indicated that the majority of toddlers with an rSBA titer between 8 and 64, and some of those with an hSBA result of <4, have mounted a protective immune response with the induction of immunological memory...
- Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92
C E Cameron
Department of Medicine, University of Washington, Seattle, WA 98195, USA
J Infect Dis 181:1401-13. 2000
..pallidum challenge. These results demonstrate that Tp92 is an invariant, immunoprotective antigen that may be present on the surface of T. pallidum and may represent a potential vaccine candidate for syphilis...
- Antibody profiles characteristic of Mycobacterium tuberculosis infection state
University of Medicine and Dentistry of New Jersey, Newark, USA
Infect Immun 73:6846-51. 2005
..tuberculosis antigens varied during infection. Together, the data indicate that antigen composition of tubercle bacilli varies with stage of infection and that immunoprofiling can distinguish between tuberculosis states...
- Facing the crisis: improving the diagnosis of tuberculosis in the HIV era
Mark D Perkins
Foundation for Innovative New Diagnostics, Geneva, Switzerland
J Infect Dis 196:S15-27. 2007
..In this article, we will define the need for better TB tests and describe technologies being developed to meet that need...
- Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins
Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Lund, Sweden
Infect Immun 69:7187-9. 2001
..We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG...
- Immunogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) when coadministered with different neisseria meningitidis serogroup C conjugate vaccines
University School of Medical Sciences and Regional Medical Center for Mother and Child, Poznan, Poland
Pediatr Infect Dis J 28:S77-88. 2009
- Genetic variation and heritability of the antibody response to Mycobacterium avium subspecies paratuberculosis in Danish Holstein cows
Department of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Denmark
J Dairy Sci 87:2108-13. 2004
..e., heavy bacterial shedders may have been represented among the cows sampled. It does not appear that intrauterine transmission is of major importance in the transmission of paratuberculosis...
- High prevalence of natural Chlamydophila species infection in calves
Department of Pathobiology, College of Veterinary Medicine, Auburn University, 270 Greene Hall, Auburn, AL 36849 5519, USA
J Clin Microbiol 42:5664-72. 2004
..02). Collectively, crowding strongly enhances the frequency and intensity of highly prevalent Chlamydophila infections in cattle...
- Leptospirosis in a subsistence farming community in Brazil
Henio G Lacerda
Department of Infectious Diseases, Universidade Federal do Rio Grande do Norte, CP 1624, Natal, RN, 59078 970, Brazil
Trans R Soc Trop Med Hyg 102:1233-8. 2008
..Additional studies are needed to characterize the mode of transmission in this region...
- Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans
J K Ma
Department of Immunology, United Medical and Dental Schools, Guy s Hospital, London, UK
Nat Med 4:601-6. 1998
..These findings could be extended to the immunotherapeutic prevention of other mucosal infections in humans and animals...
- The success and failure of BCG - implications for a novel tuberculosis vaccine
Statens Serum Institute, Department of Infectious Disease Immunology, Artillerivej 5, 2300 Copenhagen S, Denmark
Nat Rev Microbiol 3:656-62. 2005
..Here, we discuss the potential mechanisms behind the variation of BCG efficacy and their implications for an improved TB vaccination strategy...
- IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G
Ulrich von Pawel-Rammingen
Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, BMC, B14, SE 221 84 Lund, Sweden
EMBO J 21:1607-15. 2002
..pyogenes by phagocytic cells. This and additional observations on the distribution and expression of the ideS gene indicate that IdeS represents a novel and significant bacterial virulence determinant, and a potential therapeutic target...
- In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity
Herman F Staats
Department of Pathology, Box 3712, DUMC, Durham, NC 27710, USA
Infect Immun 75:5443-52. 2007
..Thus, this LeTx neutralization assay may be a more biologically relevant neutralization assay to predict the in vivo protective capacity of LeTx-neutralizing antibodies...
- Immune responses to defined antigens of Mycobacterium bovis in cattle experimentally infected with Mycobacterium kansasii
W R Waters
United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, P O Box 70, Ames, IA 50010 0070, USA
Clin Vaccine Immunol 13:611-9. 2006
..bovis infection. These findings indicate that M. kansasii infection of calves elicits specific responses that may confound the interpretation of bovine tuberculosis tests...
- Search for correlates of protective immunity conferred by anthrax vaccine
Department of Biotechnology, Israel Institute for Biological Research, Ness-Ziona 74100, Israel
Infect Immun 69:2888-93. 2001
- Prevalence of Chlamydiaceae and Mollicutes on the genital mucosa and serological findings in dairy cattle
Clinic for Obstetrics, Gynaecology and Andrology, University of Veterinary Sciences, 1210 Vienna, Austria
Vet Microbiol 127:325-33. 2008
..diversum existed in 12% of cervical and 36% of vaginal swabs and was found in 8 out of 17 animals with vaginitis. Out of the animals tested, 44.9% were seropositive for Chlamydiaceae, 14.8% for M. bovis and 27.3% for M. bovigenitalium...
- Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood
Hoda M Malaty
Department of Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, TX 77030, USA
Lancet 359:931-5. 2002
..Helicobacter pylori infection is common worldwide, but the time of acquisition is unclear. We investigated this issue in a cohort of children selected retrospectively from a population followed up for 21 years...
- Immunogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) compared to the licensed 7vCRM vaccine
Vaccine Research Center, University of Tampere Medical School, Tampere, Finland
Pediatr Infect Dis J 28:S66-76. 2009
..The immunogenicity of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) was assessed and compared with the 7-valent pneumococcal conjugate vaccine (7vCRM)...
- Vaccine-induced protection against gastrointestinal bacterial infections in the absence of secretory antibodies
Tania K Uren
The CRC for Vaccine Technology, The University of Melbourne, Department of Microbiology and Immunology, Melbourne, Victoria 3010, Australia
Eur J Immunol 35:180-8. 2005
..rodentium, but is not essential for protection against re-infection with S. typhimurium or C. rodentium...
- Humoral and cell-mediated adaptive immune responses are required for protection against Burkholderia pseudomallei challenge and bacterial clearance postinfection
Gareth D Healey
Host Pathogen Analysis, Bldg 7A, Rm 201, Dstl, Porton Down, Salisbury SP4 0JQ, United Kingdom
Infect Immun 73:5945-51. 2005
..These results indicate the importance of both cell-mediated and humoral immune mechanisms in protection against intracellular pathogens...
- Multiple infections and subsequent cardiovascular events in the Heart Outcomes Prevention Evaluation (HOPE) Study
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Circulation 107:251-7. 2003
- Early induction of humoral and cellular immune responses during experimental Mycobacterium avium subsp. paratuberculosis infection of calves
W R Waters
Bacterial Diseases of Livestock Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, Iowa 50010, USA
Infect Immun 71:5130-8. 2003
..Additionally, this study confirms that mycobacteria-specific antibody is detectable early in the course of experimental Johne's disease, even preceding the development of specific cell-mediated responses...
- Comparison of carboxylated and Penta-His microspheres for semi-quantitative measurement of antibody responses to His-tagged proteins
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
J Immunol Methods 335:121-5. 2008
..Therefore, we conclude that for developing a multiplex assay for semi-quantitative measurement of antibody responses against His-tagged proteins the best microspheres to use are the carboxylated ones...
- Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
PLoS Med 2:e15. 2005
- A newly identified protein of Leptospira interrogans mediates binding to laminin
Mariana T Longhi
Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil 1500, 05503 900 Sao Paulo, SP, Brazil
J Med Microbiol 58:1275-82. 2009
..Taken together, these data indicate that this newly identified membrane protein is expressed during natural infection and may play a role in mediating adhesion of L. interrogans to its host...
- Limited role of antibody in clearance of Streptococcus pneumoniae in a murine model of colonization
Tera L McCool
Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6076, USA
Infect Immun 72:5807-13. 2004
..These results demonstrate that antibody is not required for clearance of pneumococcal colonization in mice...
- Serological characterisation of anti-endotoxin sera directed against the conjugates of oligosaccharide core of Escherichia coli type R1, R2, R3, J5 and Salmonella Ra with tetanus toxoid
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Wrocław, Poland
FEMS Immunol Med Microbiol 16:21-30. 1996
..These reactions were shown in both the ELISA assay and the immunoblotting test...
- Increasing the interaction of Borrelia burgdorferi with decorin significantly reduces the 50 percent infectious dose and severely impairs dissemination
Department of Pathobiological Sciences, Louisiana State University, Skip Bertman Drive at River Road, Baton Rouge, LA 70803, USA
Infect Immun 75:4272-81. 2007
..Taken together, the study highlights the importance of controlling surface antigen expression in the infectivity, dissemination, tissue colonization, pathogenicity, and persistence of B. burgdorferi during mammalian infection...
- [Leptospiral infection and subclinical presentation among children in Salvador, Bahia]
Hagamenon R Silva
Centro de Estudos de Infectologia Pediátrica, Hospital Couto Maia, Secretaria de Saude do Estado da Bahia, Brasil
Rev Soc Bras Med Trop 36:227-33. 2003
..In conclusion, leptospiral infection in children (from 2 to 15 years of age) in Salvador is underestimated, because it is asymptomatic or presents as a cold syndrome simile...
- Laboratory findings in cows after experimental infection with Ehrlichia phagocytophila
Department of Veterinary Internal Medicine, University of Zurich, Switzerland
Clin Diagn Lab Immunol 4:643-7. 1997
..E. phagocytophila DNA was detected in blood samples by nested PCR from 1 to 2 days before to 2 to 12 days after the organisms were identified microscopically. In milk samples, E. phagocytophila DNA was detected for an average of 11 days...
- Leptospiral infection: a household serosurvey in urban and rural communities in Barbados and Trinidad
C O Everard
Leptospira Laboratory, St Michael, Barbados
Ann Trop Med Parasitol 84:255-66. 1990
..Lack of an inside toilet was associated with an increase in seropositivity on both islands. There was little evidence of household clustering of seropositive cases...
- Anthrax capsule vaccine protects against experimental infection
Donald J Chabot
US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21701, USA
Vaccine 23:43-7. 2004
..Surprisingly, some protection was also observed when protective antigen was conjugated to itself...
- Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis
Defence Science and Technology Laboratory, Porton Down, Salisbury SP4 0JQ, UK
J Med Microbiol 53:1177-82. 2004
..This study is the first time antigens protective by active immunization have been identified and suggests that polysaccharides have potential as vaccine candidates against melioidosis...
- Protective immunization against inhalational anthrax: a comparison of minimally invasive delivery platforms
John A Mikszta
BD Technologies, 21 Davis Dr, Research Triangle Park, NC 27709, USA
J Infect Dis 191:278-88. 2005
..The novel vaccine/device combinations described here have the potential to improve the efficacy of rPA and other biodefense vaccines...
- Discovery of a new capsular serotype (6C) within serogroup 6 of Streptococcus pneumoniae
In Ho Park
Department of Pathology, University of Alabama at Birmingham, 845 19th Street South BBRB 614, Birmingham, AL 35294, USA
J Clin Microbiol 45:1225-33. 2007
..This study also demonstrates that a new serotype may exist within an established and well-characterized serogroup or serotype...
- Aerogenic vaccination with a Burkholderia mallei auxotroph protects against aerosol-initiated glanders in mice
Ricky L Ulrich
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702, USA
Vaccine 23:1986-92. 2005
..Thus, live attenuated strains that promote a Th1-like Ig response may serve as promising vaccine candidates against aerosol infection with B. mallei...
- Intranasal vaccination with a secreted chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production
Ashlesh K Murthy
Department of Biology, University of Texas at San Antonio, 6900N Loop 1604W, San Antonio, TX 78249, USA
Infect Immun 75:666-76. 2007
..Together, these results demonstrate that secreted chlamydial antigens may be novel vaccine candidates to induce protective immunity...
- Naturally-acquired immunity to Neisseria meningitidis group A
Schneider Children s Medical Center of Israel, Petach Tikva, Israel
Vaccine 23:977-83. 2005
..Cross-reacting group A anticapsular antibodies are prevalent in North American and Ugandan sera, but bactericidal activity is infrequent and when present is largely directed at non-capsular antigens...
- Complement activation and formation of the membrane attack complex on serogroup B Neisseria meningitidis in the presence or absence of serum bactericidal activity
Department of Medical Microbiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Infect Immun 70:3752-8. 2002
..These findings support the hypothesis that proper MAC insertion rather than the quantity of MAC formed on the bacterial surface is of importance for efficient lysis of meningococci...
- Bacterial determinants of persistent throat colonization and the associated immune response in a primate model of human group A streptococcal pharyngeal infection
C D Ashbaugh
Channing Laboratory, Boston, MA 02115, USA
Cell Microbiol 2:283-92. 2000
- Evaluation of a commercial ELISA for diagnosis of paratuberculosis in cattle
D A Dargatz
USDA:APHIS Centers for Epidemiology and Animal Health, Fort Collins, CO 80521, USA
J Am Vet Med Assoc 218:1163-6. 2001
..Practitioners must be aware of variability in the sensitivity of the test, which depends on the clinical and shedding status of the cattle, because this may affect interpretation of test results...
- A community-based seroepidemiologic study of Helicobacter pylori infection in Mexico
Unidad de Investigación Médica en Enfermedades Infecciosas, Instituto Mexicano del Seguro Social, Mexico City, Mexico
J Infect Dis 178:1089-94. 1998
..42), and low socioeconomic level (OR, 1.43) were risk factors for infection. Prevalence was similar in urban and in rural communities (OR, 0.95). This study is the largest community-based seroepidemiologic study of H. pylori to date...
- Evaluation of five antibody detection tests for diagnosis of bovine paratuberculosis
Michael T Collins
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Dr, Madison, WI 53706 1102, USA
Clin Diagn Lab Immunol 12:685-92. 2005
..paratuberculosis in its feces. If used judiciously and interpreted quantitatively, these ELISAs are useful tools in support of paratuberculosis control programs in dairy herds...
- Concentration of antipneumococcal antibodies as a serological correlate of protection: an application to acute otitis media
Jukka T Jokinen
Department of Vaccines, National Public Health Institute, Helsinki, Finland
J Infect Dis 190:545-50. 2004
..However, the serological correlates of protection have not been established for pneumococcal diseases...
- Seroprevalence of meningococcal serogroup C bactericidal antibody in England and Wales in the pre-vaccination era
Immunisation Division, PHLS Communicable Disease Surveillance Centre, 61 Colindale Avenue, London NW9 5EQ, UK
Vaccine 21:1094-8. 2003
..This study provides baseline antibody levels which will facilitate the evaluation of the meningococcal serogroup C conjugate vaccination programme...
- Dogs as sentinels for human Lyme borreliosis in The Netherlands
H A Goossens
Department of Medical Microbiology, University of Maastricht, NL-6200 MD Maastricht, The Netherlands
J Clin Microbiol 39:844-8. 2001
- Effects of a challenge dose of Salmonella Typhimurium or Salmonella Yoruba on the patterns of excretion and antibody responses of pigs
National Veterinary Institute, Uppsala, Sweden
Vet Rec 162:580-6. 2008
..65 x 10(6) cfu seroconverted later and with lower titres of antibodies, and the pigs inoculated with 0.65 x 10(3) cfu did not seroconvert. A similar pattern was observed with S Yoruba, but the responses were slower and at lower titres...
- Development of an improved vaccine for anthrax
Stephen H Leppla
National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892 4350, USA
J Clin Invest 110:141-4. 2002
- Genus and species-specific IgG and IgM antibodies for pulmonary tuberculosis
Department of Microbiology, Armed Forces Institute of Pathology, Rawalpindi
J Coll Physicians Surg Pak 14:105-7. 2004
..To evaluate three different enzyme immunoassays for serological diagnosis of pulmonary tuberculosis and to compare their diagnostic accuracy in different combinations...
- Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA
Science 319:1405-8. 2008
..Idealized M proteins appear to have promise as vaccine immunogens...
- Bactericidal monoclonal antibodies that define unique meningococcal B polysaccharide epitopes that do not cross-react with human polysialic acid
D M Granoff
Chiron Vaccines, Emeryville, CA 94608, USA
J Immunol 160:5028-36. 1998
..These Abs may be useful for the identification of molecular mimetics capable of eliciting protective Abs specific to the bacteria, without the risk of evoking autoimmune disease...
- Functional analysis of Bacillus anthracis protective antigen by using neutralizing monoclonal antibodies
Unité Toxines et Pathogénie Bactériennes, URA 2172, CNRS, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Infect Immun 72:6313-7. 2004
..This work contributes to the functional analysis of PA and offers immunotherapeutic perspectives for the treatment of anthrax disease...
- Oral vaccination of mice against tetanus with recombinant Lactococcus lactis
Department of Pathology, University of Cambridge, UK
Nat Biotechnol 15:653-7. 1997
..Chemically killed lactococci administered via the intranasal route were also able to elicit serum antibody responses of similar levels and kinetics to those induced by live bacteria...
- Molecular detection of Coxiella burnetii in the sera of patients with Q fever endocarditis or vascular infection
Unite des Rickettsies, IFR 48 CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
J Clin Microbiol 42:4919-24. 2004
..004). In patient samples with titers below 1:25,600 tested prospectively, sensitivity was 100% (7 of 7). The LCN-PCR assay may be helpful in establishing an early diagnosis of chronic Q fever...
- Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity
Jennifer A Maynard
Department of Chemical Engineering, University of Texas, Austin, TX 78712, USA
Nat Biotechnol 20:597-601. 2002
..High-affinity toxin-neutralizing antibodies may be of therapeutic value for alleviating the symptoms of anthrax toxin in infected individuals and for medium-term prophylaxis to infection...
- Changing epidemiology of Q fever in Germany, 1947-1999
Robert Koch Institut, Berlin, Germany
Emerg Infect Dis 7:789-96. 2001
..The location of recent outbreaks suggests that urbanization of rural areas may be contributing to the increase in Q fever. Prevention efforts should focus on reducing sheep-related exposures, particularly near urban areas...
- Kinetics of antibody responses in Rickettsia africae and Rickettsia conorii infections
Pierre Edouard Fournier
Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
Clin Diagn Lab Immunol 9:324-8. 2002
..We recommend that sera collected 4 weeks after the onset of signs of patients with suspected African tick-bite fever should be used for the definitive serological diagnosis of R. africae infections...