rheumatoid factor

Summary

Summary: Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.

Top Publications

  1. ncbi Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
    Solbritt Rantapaa-Dahlqvist
    Umea Universitet, Umea, Sweden
    Arthritis Rheum 48:2741-9. 2003
  2. ncbi Evolving concepts of rheumatoid arthritis
    Gary S Firestein
    Division of Rheumatology, Allergy and Immunology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0656, USA
    Nature 423:356-61. 2003
  3. ncbi Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase
    M G H van de Sande
    Division of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 70:772-7. 2011
  4. pmc Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity
    Richard J Bende
    Department of Pathology, Academic Medical Center, Netherlands Cncer Institute, 1105 AZ Amsterdam, The Netherlands
    J Exp Med 201:1229-41. 2005
  5. ncbi Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies
    D Sugiyama
    Department of Clinical Pathology and Immunology, Kobe University Graduate Schoolof Medicine, Kobe 650 0017, Japan
    Ann Rheum Dis 69:70-81. 2010
  6. pmc Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:12061-6. 2009
  7. ncbi Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    Elizabeth A Leadbetter
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nature 416:603-7. 2002
  8. ncbi Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors
    Markus M J Nielen
    Jan van Breemen Institute, Amsterdam, The Netherlands
    Arthritis Rheum 50:380-6. 2004
  9. ncbi Anti-CCP antibodies have more diagnostic impact than rheumatoid factor (RF) in a population tested for RF
    I G Silveira
    Rheumatology Department, Sao Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil
    Clin Rheumatol 26:1883-9. 2007
  10. ncbi Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in rheumatoid arthritis patients and relatives from Brazil
    Isabela Goeldner
    Laboratory of Immunopathology, Clinical Hospital, Federal University of Parana, Curitiba, Parana, Brazil
    Rheumatology (Oxford) 49:1590-3. 2010

Detail Information

Publications262 found, 100 shown here

  1. ncbi Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis
    Solbritt Rantapaa-Dahlqvist
    Umea Universitet, Umea, Sweden
    Arthritis Rheum 48:2741-9. 2003
    ..prevalence and predictive value of anti-cyclic citrullinated peptide (anti-CCP) antibodies in individuals who subsequently developed rheumatoid arthritis (RA) and to determine the relationship to rheumatoid factor (RF) of any isotype.
  2. ncbi Evolving concepts of rheumatoid arthritis
    Gary S Firestein
    Division of Rheumatology, Allergy and Immunology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0656, USA
    Nature 423:356-61. 2003
    ..Based on the pathogenic mechanisms, specific therapeutic interventions can be designed to suppress synovial inflammation and joint destruction in rheumatoid arthritis...
  3. ncbi Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase
    M G H van de Sande
    Division of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 70:772-7. 2011
    ..It is currently unknown whether the disease process starts in the synovium, the primary target of RA, or at other sites in the body...
  4. pmc Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity
    Richard J Bende
    Department of Pathology, Academic Medical Center, Netherlands Cncer Institute, 1105 AZ Amsterdam, The Netherlands
    J Exp Med 201:1229-41. 2005
    ..Interestingly, RF-CDR3 homology and t(11;18) appeared to be mutually exclusive features and RF-CDR3 homology was not encountered in any of the 19 pulmonary MALT lymphomas studied...
  5. ncbi Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies
    D Sugiyama
    Department of Clinical Pathology and Immunology, Kobe University Graduate Schoolof Medicine, Kobe 650 0017, Japan
    Ann Rheum Dis 69:70-81. 2010
    ..To assess whether smoking is a risk factor for developing rheumatoid arthritis (RA)...
  6. pmc Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
    Dwight H Kono
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:12061-6. 2009
    ..7, -9) signaling, we show these endosomal TLRs are required for optimal production of IgG autoAbs, IgM rheumatoid factor, and other clinical parameters of disease in 2 lupus strains, B6-Fas(lpr) and BXSB...
  7. ncbi Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    Elizabeth A Leadbetter
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nature 416:603-7. 2002
    ..an antigen receptor specific for self-immunoglobulin-gamma (IgG) make a class of autoantibodies known as rheumatoid factor (RF)...
  8. ncbi Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors
    Markus M J Nielen
    Jan van Breemen Institute, Amsterdam, The Netherlands
    Arthritis Rheum 50:380-6. 2004
    ..The present study was undertaken to investigate this...
  9. ncbi Anti-CCP antibodies have more diagnostic impact than rheumatoid factor (RF) in a population tested for RF
    I G Silveira
    Rheumatology Department, Sao Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil
    Clin Rheumatol 26:1883-9. 2007
    To compare the diagnostic powers of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) in a population selected for its high statistical relevance, over a 6-month period, an informed consent to test for anti-CCP was ..
  10. ncbi Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in rheumatoid arthritis patients and relatives from Brazil
    Isabela Goeldner
    Laboratory of Immunopathology, Clinical Hospital, Federal University of Parana, Curitiba, Parana, Brazil
    Rheumatology (Oxford) 49:1590-3. 2010
    ..To evaluate the prevalence of anti-cyclic citrullinated peptide (anti-CCP) antibodies and RF in RA patients and their relatives from Southern Brazil...
  11. ncbi Cytokines, autoantibodies and viral antibodies in premorbid and postdiagnostic sera from patients with rheumatoid arthritis: case-control study nested in a cohort of Norwegian blood donors
    K T Jørgensen
    Department of Epidemiology Research, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen, Denmark
    Ann Rheum Dis 67:860-6. 2008
    ..To assess the timing of changes in cytokines, cytokine-related markers, autoantibodies and viral antibodies in the pathogenesis of rheumatoid arthritis (RA)...
  12. ncbi Cytokine measurements and possible interference from heterophilic antibodies--problems and solutions experienced with rheumatoid factor
    Else Marie Bartels
    The Parker Institute, Department of Rheumatology, Copenhagen University Hospitals Bispebjerg and Frederiksberg, Denmark
    Methods 61:18-22. 2013
    ..Another type, rheumatoid factor (RF) is a composite of different autoimmune antibodies which can be present in both blood and synovial fluid...
  13. ncbi Declining trend in the incidence of rheumatoid factor-positive rheumatoid arthritis in Finland 1980-2000
    Oili Kaipiainen-Seppanen
    Department of Medicine, Kuopio University Hospital, P O Box 1777, 70211 Kuopio, Finland
    J Rheumatol 33:2132-8. 2006
    ..To investigate trends in the incidence of rheumatoid arthritis (RA) in Finland...
  14. ncbi Multiplexing immunoassays for cytokine detection in the serum of patients with rheumatoid arthritis: lack of sensitivity and interference by rheumatoid factor
    Sarah M Churchman
    Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Clin Exp Rheumatol 30:534-42. 2012
    ..were raised regarding their use in rheumatology due to interference by heterophilic antibodies, notably rheumatoid factor (RF)...
  15. pmc Predictors of radiographic joint damage in patients with early rheumatoid arthritis
    L M Jansen
    Jan van Breemen Instituut, Amsterdam, The Netherlands
    Ann Rheum Dis 60:924-7. 2001
    ..stiffness, disease activity score (DAS28), functional status (Health Assessment Questionnaire (HAQ) score), rheumatoid factor (IgM RF), and C reactive protein (CRP)...
  16. pmc Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis
    C Potter
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Ann Rheum Dis 68:69-74. 2009
    To determine whether rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibodies, or carriage of shared epitope (SE) and PTPN22 genetic susceptibility variants predict response to therapy in patients with rheumatoid ..
  17. ncbi Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides
    Lena Innala
    Department of Rheumatology, Department of Clinical Immunology, and Department of Transfusion Medicine, University Hospital, Umea, Sweden
    J Rheumatol 35:1002-8. 2008
    ..To evaluate the predictive values for disease progression of various antibodies against citrullinated peptide proteins (ACPA) and their relation to PTPN22 1858C/T polymorphism and HLA-DRB1 alleles in early rheumatoid arthritis (RA)...
  18. pmc Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis
    Tracey M Farragher
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 58:359-69. 2008
    ..To examine the role of the variants of the PTPN22 and HLA-DRB1 genes as predictors of mortality in inflammatory polyarthritis (IP) and rheumatoid arthritis (RA)...
  19. pmc The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register
    M Bukhari
    University of Manchester, Manchester, UK
    Arthritis Rheum 56:2929-35. 2007
    ..peptide (anti-CCP) antibodies are a stronger predictor of the severity of rheumatoid arthritis than is rheumatoid factor (RF)...
  20. pmc Clinical utility of the anti-CCP assay in patients with rheumatic diseases
    D M Lee
    Department of Medicine, Division of Rheumatology, Immunology and Allergy Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Rheum Dis 62:870-4. 2003
    ..To determine the frequency of antibodies to cyclic citrullinated peptides (CCP) in a group of patients with a diversity of rheumatic diseases...
  21. ncbi Progression of joint damage in early rheumatoid arthritis: association with HLA-DRB1, rheumatoid factor, and anti-citrullinated protein antibodies in relation to different treatment strategies
    J K de Vries-Bouwstra
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 58:1293-8. 2008
    To determine the association of HLA-DRB1, rheumatoid factor (RF), and anti-citrullinated protein antibody (ACPA) status with progression of joint damage in early rheumatoid arthritis (RA) treated according to different treatment ..
  22. pmc The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner
    Kevin D Deane
    Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Arthritis Rheum 62:3161-72. 2010
    ..To evaluate levels of biomarkers in preclinical rheumatoid arthritis (RA) and to use elevated biomarkers to develop a model for the prediction of time to future diagnosis of seropositive RA...
  23. pmc Course of radiographic damage over 10 years in a cohort with early rheumatoid arthritis
    E Lindqvist
    Department of Rheumatology, Lund University Hospital, Sweden Department of Radiology, Lund University Hospital, Sweden
    Ann Rheum Dis 62:611-6. 2003
    ..To investigate development of radiographic damage in hands and feet of patients with early rheumatoid arthritis (RA) monitored prospectively for 10 years, and to search for prognostic factors...
  24. ncbi Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis
    S Bas
    Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Rheumatology (Oxford) 42:677-80. 2003
    ....
  25. pmc Regional differences in Finland in the prevalence of rheumatoid factor in the presence and absence of arthritis
    T Korpilähde
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Ann Rheum Dis 62:353-5. 2003
    To look for possible regional differences in the prevalence of rheumatoid factor (RF) in the presence and absence of arthritis.
  26. pmc Autoantibodies in rheumatoid arthritis: rheumatoid factors and anticitrullinated protein antibodies
    Y W Song
    Division of Rheumatology, Department of Internal Medicine, Medical Research Center, Seoul National University, Seoul, Korea
    QJM 103:139-46. 2010
    ..Since rheumatoid factor (RF) was first described, a number of other autoantibodies have been discovered in RA patients...
  27. ncbi Rheumatoid factors in health and disease: structure, function, induction and regulation
    Ann M Haberman
    Department of Laboratory Medicine, Section of Immunobiology, Yale University School of Medicine, New Haven, Conn, USA
    Curr Dir Autoimmun 6:169-95. 2003
  28. ncbi Rheumatoid factor and antibodies to cyclic citrullinated Peptide differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis
    Annemarie L M A Jansen
    Jan van Breemen Instituut and the Department of Rheumatology, VU Medical Center, Amsterdam, The Netherlands
    J Rheumatol 29:2074-6. 2002
    To study the diagnostic value of IgM rheumatoid factor (RF), IgA-RF, antibodies to cyclic citrullinated peptide (anti-CCP), and combinations of these antibodies, measured at baseline, to discriminate rheumatoid arthritis (RA) from ..
  29. ncbi Effect of baseline rheumatoid factor and anticitrullinated peptide antibody serotype on rituximab clinical response: a meta-analysis
    John D Isaacs
    Newcastle University, Newcastleupon Tyne NE7 7DN, UK
    Ann Rheum Dis 72:329-36. 2013
    Studies examining the relationship between serological status (rheumatoid factor and/or anticitrullinated antibody) and rituximab treatment outcome in rheumatoid arthritis (RA) have been hampered by limited numbers of seronegative ..
  30. ncbi Anti-citrullinated protein/peptide antibodies (ACPA) in rheumatoid arthritis: specificity and relation with rheumatoid factor
    B Vander Cruyssen
    Department of Rheumatology, Ghent University Hospital, B 9000 Gent, Belgium
    Autoimmun Rev 4:468-74. 2005
    ..Also, the differences between the classical rheumatoid factor (RF) and ACPA, as well as the complementarity between both tests have recently been demonstrated more ..
  31. ncbi Rheumatoid factors: what's new?
    O M R Westwood
    European Institute for Health and Medical Sciences, Duke of Kent Building, University of Surrey, Guildford GU2 7TE, UK
    Rheumatology (Oxford) 45:379-85. 2006
  32. ncbi Rheumatoid factor interference in the determination of carbohydrate antigen 19-9 (CA 19-9)
    Mario Berth
    Immunology Department, Algemeen Medisch Laboratorium, Antwerpen, Belgium
    Clin Chem Lab Med 44:1137-9. 2006
    ..Determination of CA 19-9 on Vidas, AxSYM and Architect i2000 systems gave normal results. His rheumatoid factor concentration was very high (900 kIU/L) and assay interference was suspected.
  33. pmc Autoantibody profile in rheumatoid arthritis during long-term infliximab treatment
    Francesca Bobbio-Pallavicini
    Department of Rheumatology University of Pavia, IRCCS Policlinico S, Matteo, Pavia, Italy
    Arthritis Res Ther 6:R264-72. 2004
    ..The proportion of patients who were positive for rheumatoid factor (RF) was similar at baseline and at 78 weeks (87% and 80%, respectively)...
  34. pmc Rheumatoid arthritis: correlation between rheumatoid factor levels and CA-125 tumour marker elevation
    Nicolas Tsavaris
    Ann Rheum Dis 66:980. 2007
  35. pmc The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis
    L G M van Baarsen
    Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Ann Rheum Dis 72:1420-4. 2013
    ..Therefore, we investigated the cellular composition of the lymph node in the earliest phases of inflammatory arthritis...
  36. ncbi Superior performance of the CCP3.1 test compared to CCP2 and MCV in the rheumatoid factor-negative RA population
    Zoltan Szekanecz
    Department of Rheumatology, Institute of Medicine, University of Debrecen Medical and Health Science Center, Nagyerdei str 98, Debrecen, 4032, Hungary
    Immunol Res 56:439-43. 2013
    ..1 assay, but with special focus on the rheumatoid factor (RF)-negative RA population...
  37. ncbi Anticitrullinated protein antibodies and rheumatoid factor fluctuate in early inflammatory arthritis and do not predict clinical outcomes
    Lillian Barra
    Department of Medicine, Division of Rheumatology, St Joseph s Health Care London, University of Western Ontario, London, Ontario, Canada
    J Rheumatol 40:1259-67. 2013
    In inflammatory arthritis, rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA) are believed to be associated with more severe clinical outcomes...
  38. ncbi Rheumatoid factor as predictor of response to abatacept, rituximab and tocilizumab in rheumatoid arthritis: Systematic review and meta-analysis
    R J Maneiro
    Rheumatology Unit, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago, Spain
    Semin Arthritis Rheum 43:9-17. 2013
    To identify if rheumatoid factor (RF) is predictor of response to rituximab (RTX), abatacept (ABT), and tocilizumab (TCZ) in rheumatoid arthritis (RA).
  39. ncbi Rheumatoid factor determines structural progression of rheumatoid arthritis dependent and independent of disease activity
    Daniel Aletaha
    Division of Rheumatology, Department of Medicine 3, Medical University Vienna, and Second Department of Medicine, Hietzing Hospital, Vienna, Austria
    Ann Rheum Dis 72:875-80. 2013
    b>Rheumatoid factor (RF) is prototypic for rheumatoid arthritis (RA) and serves diagnostic and prognostic purposes...
  40. ncbi Chronic smoke exposure induces rheumatoid factor and anti-heat shock protein 70 autoantibodies in susceptible mice and humans with lung disease
    Marianna M Newkirk
    Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    Eur J Immunol 42:1051-61. 2012
    ..b>Rheumatoid factor (RF), anti-cyclic citrullinated peptides (CCPs), and anti-HSP70 autoantibodies were measured in several ..
  41. pmc Elevated rheumatoid factor and long term risk of rheumatoid arthritis: a prospective cohort study
    Sune F Nielsen
    Department of Clinical Biochemistry, 54M1, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK 2730 Herlev, Denmark
    BMJ 345:e5244. 2012
    To test whether elevated concentration of rheumatoid factor is associated with long term development of rheumatoid arthritis.
  42. pmc Antibodies against cyclic citrullinated peptides of IgG, IgA and IgM isotype and rheumatoid factor of IgM and IgA isotype are increased in unaffected members of multicase rheumatoid arthritis families from northern Sweden
    Lisbeth Arlestig
    Department of Public Health, Umea University, Umea, Sweden
    Ann Rheum Dis 71:825-9. 2012
    ..Rheumatoid factors (RFs) and antibodies against cyclic citrullinated peptides (CCPs) of IgG, IgA and IgM isotype have been shown to precede disease onset by years...
  43. ncbi The value of rheumatoid factor and anti-citrullinated protein antibodies as predictors of response to infliximab in rheumatoid arthritis: an exploratory study
    Ruth Klaasen
    Department of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Rheumatology (Oxford) 50:1487-93. 2011
    ..We investigated the relationship between the presence and levels of different RF and ACPA isotypes and the response to TNF blockade in an exploratory study...
  44. pmc The likelihood of persistent arthritis increases with the level of anti-citrullinated peptide antibody and immunoglobulin M rheumatoid factor: a longitudinal study of 376 patients with very early undifferentiated arthritis
    Maria D Mjaavatten
    Department of Rheumatology, Diakonhjemmet Hospital, P, O, Box 23 Vinderen, 0319 Oslo, Norway
    Arthritis Res Ther 12:R76. 2010
    ..the importance of the levels of anti-citrullinated peptide antibody (anti-CCP) and immunoglobulin M (IgM) rheumatoid factor (RF) in predicting development of persistent arthritis from undifferentiated arthritis (UA), and to ..
  45. ncbi Misleading results from immunoassays of serum free thyroxine in the presence of rheumatoid factor
    A G Norden
    Department of Chemical Pathology, Chase Farm Hospitals Trust, Middlesex, UK
    Clin Chem 43:957-62. 1997
    A novel interference with measurements of serum free thyroxine (FT4) caused by rheumatoid factor (RhF) is described...
  46. ncbi Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status
    So Young Bang
    Hospital for Rheumatic Diseases, Hanyang University, Seoul, South Korea
    Arthritis Rheum 62:369-77. 2010
    ....
  47. ncbi Rheumatoid factor and antibodies against citrullinated peptides in Moroccan patients with rheumatoid arthritis: association with disease parameters and quality of life
    Yousra Ibn Yacoub
    Department of Rheumatology Pr N Hajjaj Hassouni, El Ayachi Hospital, University Hospital of Rabat Sale, Sale, Morocco
    Clin Rheumatol 31:329-34. 2012
    ..Immunological status (rheumatoid factor rate, RF) and antibodies against citrullinated peptides rate (ACPAs) by the Elisa method were examined...
  48. pmc Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles
    S P Linn-Rasker
    Department of Rheumatology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, Netherlands
    Ann Rheum Dis 65:366-71. 2006
    ..To study the gene-environment interaction of tobacco exposure and shared epitope on autoantibodies in patients with rheumatoid arthritis and undifferentiated arthritis...
  49. pmc A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA
    Jason R Kolfenbach
    University of Colorado Denver, Aurora, CO, USA
    Arthritis Rheum 61:1735-42. 2009
    ..To describe a large, multicenter prospective cohort study of first-degree relatives (FDRs) of probands with rheumatoid arthritis (RA), and outline the use of such a study in investigating the natural history of RA development...
  50. ncbi Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor
    Derrick J Todd
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Arthritis Rheum 63:894-903. 2011
    Serum rheumatoid factor (RF) and other heterophilic antibodies potentially interfere with antibody-based immunoassays by nonspecifically binding detection reagents...
  51. ncbi The value of HLA-DRB1 shared epitope, -308 tumor necrosis factor-alpha gene promoter polymorphism, rheumatoid factor, anti-citrullinated peptide antibodies, and early erosions for predicting radiological outcome in recent-onset rheumatoid arthritis
    Sonsoles Reneses
    Department of Rheumatology, Virgen del Rocio University Hospital, Seville, Spain
    J Rheumatol 36:1143-9. 2009
    ..of HLA-DRB1 shared epitope (SE), -308 tumor necrosis factor-alpha (TNF-alpha) gene promoter polymorphism, rheumatoid factor (RF), anti-citrullinated peptide antibodies (anti-CCP), and baseline erosions for predicting radiological ..
  52. ncbi Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis
    Nikolaos A Patsopoulos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Ann Rheum Dis 69:561-6. 2010
    ..Furthermore, additional independent studies have investigated the same or highly linked polymorphisms in the same regions...
  53. ncbi Predicting factors for severity of rheumatoid arthritis: a prospective multicenter cohort study of 172 patients over 3 years
    E Wagner
    Special Hospital NOEGKK, Baden, Austria
    Rheumatol Int 27:1041-8. 2007
    ..Higher initial values for erythrocyte sedimentation rate, IgG and IgM rheumatoid factor, serum concentration of cartilage oligomeric matrix protein, Health Assessment Questionnaire score, Larsen ..
  54. pmc Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor
    Alejandro Balsa
    Servicio de Reumatologia, Hospital Universitario La Paz, Paseo de la Castellana, 261, Madrid, 28046, Spain
    Arthritis Res Ther 12:R62. 2010
    The purpose of this study was to investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis (RA) and production of antibodies against citrullinated proteins (ACPA) and rheumatoid factor (RF).
  55. ncbi Anti-cyclic citrullinated peptide antibody isotypes in rheumatoid arthritis: association with disease duration, rheumatoid factor production and the presence of shared epitope
    G Lakos
    Laboratory of Immunology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    Clin Exp Rheumatol 26:253-60. 2008
    ..Recent evidence also points to their direct involvement in the pathophysiology. Little information is available, however, regarding the isotype distribution of anti-CCP antibodies and the characteristics of IgA and IgM anti-CCP...
  56. ncbi Arthritis development in patients with arthralgia is strongly associated with anti-citrullinated protein antibody status: a prospective cohort study
    W H Bos
    Jan van Breemen Instituut, Amsterdam, The Netherlands
    Ann Rheum Dis 69:490-4. 2010
    ..Anti-citrullinated protein antibodies (ACPA) are associated with increased risk for rheumatoid arthritis...
  57. ncbi Association of rheumatoid arthritis treatment response and disease duration with declines in serum levels of IgM rheumatoid factor and anti-cyclic citrullinated peptide antibody
    T R Mikuls
    Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Arthritis Rheum 50:3776-82. 2004
    To examine the association of treatment response and disease duration with changes in rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody levels among patients with rheumatoid arthritis (RA).
  58. ncbi Anti-cyclic citrullinated peptide antibody in rheumatoid arthritis: relation with disease aggressiveness
    N del Val del Amo
    Rheumatology Department, Navarra Hospital, Pamplona, Spain
    Clin Exp Rheumatol 24:281-6. 2006
    ..To analyse the value of the anti-cyclic citrullinated peptide antibody (anti-CCP) in patients with rheumatoid arthritis (RA) as a prognostic factor, as well as its relationship with disease activity...
  59. ncbi Rheumatoid factors: what do they tell us?
    Marianna M Newkirk
    J Rheumatol 29:2034-40. 2002
  60. pmc Diagnostic performances of anti-cyclic citrullinated peptides antibody and antifilaggrin antibody in Korean patients with rheumatoid arthritis
    Suk Woo Choi
    Department of Laboratory Medicine, Eulji University, School of Medicine, Daejeon, Korea
    J Korean Med Sci 20:473-8. 2005
    ..Diagnostic performances of the anti-CCP assay and AFA assay were compared with that of rheumatoid factor (RF) latex fixation test...
  61. ncbi Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors
    S Bas
    Division of Rheumatology, Department of Internal Medicine, University Hospital, Geneva, Switzerland
    Rheumatology (Oxford) 41:809-14. 2002
    ....
  62. pmc Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cells
    Linda Mathsson
    Unit of Clinical Immunology, Uppsala University, Uppsala, Sweden
    Arthritis Res Ther 8:R64. 2006
    ..b>Rheumatoid factor (RF) develop in response to ICs in many clinical and experimental settings...
  63. pmc Prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis
    T Avcin
    Department of Paediatrics, University of Ljubljana, Slovenia, Italy
    Ann Rheum Dis 61:608-11. 2002
    ..Antibodies against cyclic citrullinated peptide (anti-CCP) are considered to be specific for rheumatoid arthritis (RA)...
  64. ncbi Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population
    Ann W Morgan
    Leeds Musculoskeletal Biomedical Research Unit, Institute of Molecular Medicine, University of Leeds, St James University Hospital, Leeds, UK
    Arthritis Rheum 60:2565-76. 2009
    To define interactions between the HLA-DRB1 shared epitope (SE), PTPN22, and smoking in cyclic citrullinated peptide (CCP) antibody- and rheumatoid factor (RF)-positive and -negative rheumatoid arthritis (RA).
  65. ncbi The influence of mannose binding lectin polymorphisms on disease outcome in early polyarthritis. TIRA Group
    S Jacobsen
    Department of Rheumatology, Hvidovre Hospital, Copenhagen University Hospital, Denmark
    J Rheumatol 28:935-42. 2001
    ....
  66. ncbi The extent of the anti-citrullinated protein antibody repertoire is associated with arthritis development in patients with seropositive arthralgia
    Lotte A van de Stadt
    Department of Immunopathology, Sanquin Research and Landsteiner Laboratorium, Academic Medical Center, Amsterdam, The Netherlands
    Ann Rheum Dis 70:128-33. 2011
    ..To determine the fine specificity of anti-citrullinated protein antibodies (ACPA) in the early phase of arthritis development, the ACPA repertoire in arthralgia patients and the association with arthritis development were studied...
  67. ncbi Prognostic markers of radiographic progression in early rheumatoid arthritis
    Jorg J Goronzy
    Mayo Clinic, Rochester, Minnesota 55905, USA
    Arthritis Rheum 50:43-54. 2004
    ..To identify prognostic markers that are predictive of progressive erosive disease in patients with early rheumatoid arthritis (RA)...
  68. ncbi The relationship between disease activity and radiologic progression in patients with rheumatoid arthritis: a longitudinal analysis
    Paco M J Welsing
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:2082-93. 2004
    ....
  69. ncbi Usefulness of anti-CCP antibodies in patients with hepatitis C virus infection with or without arthritis, rheumatoid factor, or cryoglobulinemia
    Feng Cheng Liu
    Division of Rheumatology Immunology Allergy, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
    Clin Rheumatol 27:463-7. 2008
    ..was to determine the prevalence of anti-CCP antibodies in HCV-infected patients with or without arthritis, rheumatoid factor (RF), or cryoglobulinemia and to investigate whether anti-CCP antibodies may be helpful in discriminating ..
  70. pmc The effect of etanercept on anti-cyclic citrullinated peptide antibodies and rheumatoid factor in patients with rheumatoid arthritis
    H A Chen
    Section of Allergy Immunology Rheumatology, Department of Medicine, Veterans General Hospital Taipei, Taiwan
    Ann Rheum Dis 65:35-9. 2006
    To evaluate the changes in anti-cyclic citrullinated peptide antibodies (anti-CCP) and rheumatoid factor (RF) following etanercept treatment in patients with rheumatoid arthritis.
  71. pmc Levels of anti-citrullinated protein antibodies and IgM rheumatoid factor are not associated with outcome in early arthritis patients: a cohort study
    Jennie Ursum
    Jan van Breemen Institute, Department of Rheumatology, Dr, Jan van Breemenstraat 2, 1056 AB Amsterdam, The Netherlands
    Arthritis Res Ther 12:R8. 2010
    To investigate whether baseline levels of anti-citrullinated protein antibody (ACPA) or IgM rheumatoid factor (IgM-RF) and changes in the year thereafter are associated with disease activity, functional and radiographic outcome in early ..
  72. pmc Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis
    R Goldbach-Mansky
    Arthritis and Rheumatism Branch, National Institute of Arthritis and Musculoskeltal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Ann Rheum Dis 64:715-21. 2005
    ..Raised granzyme B in serum and synovium of patients with rheumatoid arthritis suggests a role for cytotoxic T cells and natural killer cells in the pathogenesis of this disease...
  73. pmc Rheumatoid factor measured by fluoroimmunoassay: a responsive measure of rheumatoid arthritis disease activity that is associated with joint damage
    E Knijff-Dutmer
    Rheumatology Twente, Medisch Spectrum Twente, Enschede, The Netherlands
    Ann Rheum Dis 61:603-7. 2002
    ..Further, to study the association of RFs and other disease activity parameters with radiological joint damage, especially in individual patients...
  74. ncbi Rheumatoid factor is the strongest predictor of radiological progression of rheumatoid arthritis in a three-year prospective study in community-recruited patients
    O Vittecoq
    Inserm Unité 519 and Institut Fédératif de Recherche Multidisciplinaire sur les Peptides IFRMP 23, Faculte de Medecine et de Pharmacie, Rouen, France
    Rheumatology (Oxford) 42:939-46. 2003
    ..To evaluate the predictive value of clinical, biological and radiological parameters for the prognosis of rheumatoid arthritis (RA) in a community-recruited cohort...
  75. pmc Immediate determination of ACPA and rheumatoid factor--a novel point of care test for detection of anti-MCV antibodies and rheumatoid factor using a lateral-flow immunoassay
    Franziska Renger
    Department of Rheumatology and Clinical Immunology, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin, Germany
    Arthritis Res Ther 12:R120. 2010
    ..The aim of this study was to develop and evaluate a point of care test (POCT) for detection of anti-MCV antibodies immediately at the first visit or at the bed side...
  76. pmc Rheumatoid factor seropositivity is inversely associated with oral contraceptive use in women without rheumatoid arthritis
    Shailaja S Bhatia
    Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, Denver, 4200 East Ninth Avenue, Box B119, Denver, CO 80262, USA
    Ann Rheum Dis 66:267-9. 2007
    To examine whether oral contraceptive use is associated with the presence of serum rheumatoid factor in women of reproductive age without rheumatoid arthritis.
  77. pmc O-glycosylated IgA rheumatoid factor induces IgA deposits and glomerulonephritis
    Masako Otani
    Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
    J Am Soc Nephrol 23:438-46. 2012
    ..In this study, mice implanted with hybridoma secreting 6-19 IgA anti-IgG2a rheumatoid factor, but not 46-42 IgA rheumatoid factor bearing the same IgA allotype, developed mesangial deposits consisting ..
  78. pmc Rheumatoid factor and antibodies to cyclic citrullinated peptides are associated with severe extra-articular manifestations in rheumatoid arthritis
    C Turesson
    Department of Rheumatology, Malmo University Hospital, Södra Förstadsgatan 101, S 205 02 Malmo, Sweden
    Ann Rheum Dis 66:59-64. 2007
    To study antibodies to cyclic citrullinated peptides (anti-CCP) and rheumatoid factor in patients with active, severe extra-articular rheumatoid arthritis (ExRA) compared with controls without ExRA.
  79. ncbi Basal anti-cyclic citrullinated peptide (anti-CCP) antibody levels and a decrease in anti-CCP titres are associated with clinical response to adalimumab in rheumatoid arthritis
    M Cuchacovich
    Rheumatology Section, Department of Medicine, Clinical Hospital, University of Chile
    Clin Exp Rheumatol 26:1067-73. 2008
    ..To investigate the effect of adalimumab treatment on anti-cyclic citrullinated peptide antibodies (anti-CCP) in patients with rheumatoid arthritis (RA)...
  80. ncbi Anti-citrullinated peptide antibodies and rheumatoid factor in Sudanese patients with Leishmania donovani infection
    Erik Ahlin
    Unidade de Imunologia Clinica, Uppsala University, Suecia
    Rev Bras Reumatol 51:579-86. 2011
    The present study evaluated the presence of anti-cyclic citrullinated peptides antibodies (anti-CCP), rheumatoid factor (RF), and circulating immune complexes (CIC) in Sudanese patients infected with the Leishmania donovani parasite.
  81. ncbi Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age
    Thomas Frisell
    Karolinska Institutet, Solna, Sweden
    Arthritis Rheum 65:2773-82. 2013
    ..arthritis (RA) in 3 large population-representative samples and to test if familial aggregation is affected by rheumatoid factor (RF)/anti-citrullinated protein antibody (ACPA) status, type of relative, sex, and age at onset of RA.
  82. ncbi Multiplexed immunoassay for detection of rheumatoid factors by FIDISTM technology
    I Abreu
    Faculty of Medical Sciences, Department of Immunology, New University of Lisbon, Lisbon, Portugal
    Ann N Y Acad Sci 1050:357-63. 2005
    ..2%; ELISA human 93.2%, 95.5%; and ELISA animal 74.6%, 91.3%. The results showed the efficiency of FIDIS with analytical performance equivalent to the conventional methods, but having the advantage of giving quantitative results (IU/mL)...
  83. ncbi Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells
    Ann Marshak-Rothstein
    Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA
    J Endotoxin Res 10:247-51. 2004
    ..stranded DNA fragments ( approximately 600 bp) can all effectively stimulate transgenic B cells expressing a rheumatoid factor receptor by a TLR9-dependent process...
  84. pmc Rheumatoid factor, complement, and mixed cryoglobulinemia
    Peter D Gorevic
    Mount Sinai School of Medicine, Division of Rheumatalogy, Annenberg Building, Room 21 056, One Gustave L Levy Place, New York, NY, USA
    Clin Dev Immunol 2012:439018. 2012
    ..Potential activators include monoclonal IgM rheumatoid factor (RF), IgG antibodies, and the complexing of the two in the cold, perhaps modulated by the rheology and ..
  85. pmc Perinatal and early childhood risk factors associated with rheumatoid factor positivity in a healthy paediatric population
    Kendra A Young
    Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Box B119, Denver, CO 80262, USA
    Ann Rheum Dis 66:179-83. 2007
    To examine perinatal and childhood risk factors for the presence of rheumatoid factor in healthy children.
  86. ncbi Elevated levels of IgM and IgA antibodies to Proteus mirabilis and IgM antibodies to Escherichia coli are associated with early rheumatoid factor (RF)-positive rheumatoid arthritis
    M M Newkirk
    McGill University Health Centre, 1650 Cedar Ave, Montreal, QC, Canada H3G 1A4
    Rheumatology (Oxford) 44:1433-41. 2005
    ..Antibodies to Proteus mirabilis were previously detected in patients with established rheumatoid arthritis (RA). We examined the prevalence of antibodies to P. mirabilis and their associations with RA in early synovitis patients...
  87. ncbi Distinct bacterial colonization patterns of Escherichia coli subtypes associate with rheumatoid factor status in early inflammatory arthritis
    Marianna M Newkirk
    Research Institute of McGill University Health Centre, Montreal, QC, Canada
    Rheumatology (Oxford) 49:1311-6. 2010
    ..The strongest association was observed for RF(+) RA. We compare colonization patterns of these bacteria, and the anti-bacterial antibody levels in early onset RF(+) and RF(-) inflammatory arthritis...
  88. pmc Anti-CCP antibody and rheumatoid factor concentrations predict greater disease activity in men with rheumatoid arthritis
    Benjamin J Miriovsky
    Department of Internal Medicine, Section of Rheumatology and Immunology, 986270 Nebraska Medical Center, Omaha, NE 68198 6270, USA
    Ann Rheum Dis 69:1292-7. 2010
    To examine associations of anti-cyclic citrullinated peptide (aCCP) antibody and rheumatoid factor (RF) concentrations with future disease activity in men with rheumatoid arthritis (RA).
  89. pmc Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites
    Robin A Herlands
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Eur J Immunol 37:3339-51. 2007
    ..antibody, presumably by forming immune complexes with released nuclear material, drives activation of rheumatoid factor B cells in AM14 Tg mice...
  90. ncbi Moyamoya disease associated with positive findings for rheumatoid factor and myeloperoxidase-anti-neutrophil cytoplasmic antibody
    Y Yanagawa
    Departments of Traumatology and Critical Care Medicine, National Defense Medical College NDMC, Tokorozawa, Saitama, Japan
    West Indian Med J 56:282-4. 2007
    ..This case indicates that immunological factors, inflammation or vasculitis might have possibly been associated with the development of either an obstruction or stenosis of the intracranial internal carotid arteries...
  91. ncbi The presence of anti-citrullinated protein antibodies (ACPA) and rheumatoid factor on patients with rheumatoid arthritis (RA) does not interfere with the chance of clinical remission in a follow-up of 3 years
    Licia Maria Henrique da Mota
    Rheumatology Division, Hospital Universitário de Brasília da Universidade de Brasília, SHLS 716 916 Bloco E salas 501 502, Centro Médico de Brasília, Asa Sul, Brasilia, DF CEP 71660020, Brazil
    Rheumatol Int 32:3807-12. 2012
    ..arthritis (<12 months of symptoms) in order to determine the association between serological markers (rheumatoid factor (RF), anti-citrullinated protein antibodies) such as anti-cyclic citrullinated peptide antibodies (anti-CCP) ..
  92. ncbi Anti-CCP antibodies: the new rheumatoid factor in the serology of rheumatoid arthritis
    Walther J van Venrooij
    Department of Biochemistry 161, University of Nijmegen, Nijmegen, The Netherlands
    Autoimmun Rev 3:S17-9. 2004
  93. pmc Differential requirements for induction of total immunoglobulin and physiological rheumatoid factor production by human peripheral blood B cells
    W J van Esch
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Exp Immunol 123:496-504. 2001
    ..Together, these results indicate that conditions for the induction of total Ig and physiological RFs are different...
  94. ncbi Lack of seroconversion of rheumatoid factor and anti-cyclic citrullinated peptide in patients with early inflammatory arthritis: a systematic literature review
    Lillian Barra
    St Joseph s Health Care, London N6A 4V2, ON, Canada
    Rheumatology (Oxford) 50:311-6. 2011
    ..The objective of this study is to determine the per cent RF and anti-CCP seroconversion in EIA patients at 1-5 years of follow-up: 80% of established RA is RF or CCP positive...
  95. ncbi Erythrocyte sedimentation rate, C-reactive protein, or rheumatoid factor are normal at presentation in 35%-45% of patients with rheumatoid arthritis seen between 1980 and 2004: analyses from Finland and the United States
    Tuulikki Sokka
    Jyvaskyla Central Hospital, 40620 Jyvaskyla, Finland
    J Rheumatol 36:1387-90. 2009
    To analyze erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor (RF) tests in 2 databases of consecutive patients with rheumatoid arthritis (RA) over 25 years between 1980 and 2004, in Finland and the USA.
  96. ncbi Antinuclear antibody and rheumatoid factor in silica-exposed workers
    Omid Aminian
    Department of Occupational Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Arh Hig Rada Toksikol 60:185-90. 2009
    ..The aim of this study was to measure antinuclear antibody (ANA) and rheumatoid factor (RF) levels in foundry workers exposed to silica and to compare them with a control group without such ..
  97. ncbi Thyroxin overdose due to rheumatoid factor interferences in thyroid-stimulating hormone assays
    Agnès Georges
    Department of Nuclear Medicine, University Hospital and University Bordeaux, Pessac, France
    Clin Chem Lab Med 49:873-5. 2011
    Immunoassays are susceptible to interferences by anti-hormone antibodies, heterophilic antibodies or rheumatoid factor (RF).
  98. pmc Cryoglobulinemia induced by a murine IgG3 rheumatoid factor: skin vasculitis and glomerulonephritis arise from distinct pathogenic mechanisms
    L Reininger
    Department of Pathology, University of Geneva, Switzerland
    Proc Natl Acad Sci U S A 87:10038-42. 1990
    ..mAb)--6-19 (gamma 3 heavy chain and kappa light chain), exhibiting both cryoglobulin and anti-IgG2a rheumatoid factor (RF) activities--derived from the MRL-lpr/lpr autoimmune mouse...
  99. ncbi The diagnostic utility of the anti-CCP antibody test is no better than rheumatoid factor in South Africans with early rheumatoid arthritis
    Bridget Hodkinson
    Division of Rheumatology, Chris Hani Baragwanath Hospital and University of the Witwatersrand, P O Bertsham, Johannesburg, South Africa
    Clin Rheumatol 29:615-8. 2010
    ..A cross-sectional study comparing the rheumatoid factor (RF) and aCCP status in RA patients and a control group consisting of healthy subjects, and patients with ..
  100. ncbi [Study on the differential gene expression of peripheral CD4+ among rheumatoid arthritis patients of cold or heat syndrome type with or without rheumatoid factor]
    Cheng Xiao
    Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700
    Zhongguo Zhong Xi Yi Jie He Za Zhi 26:689-93. 2006
    To explore the differential gene expression of peripheral CD4+ among rheumatoid arthritis (RA) patients of cold or heat syndrome type with or without rheumatoid factor (RF).
  101. ncbi Rheumatoid factor interference in a tacrolimus immunoassay
    Bernardí Barceló Martín
    Servei d Anàlisis Clíniques, Hospital Son Dureta, Palma de Mallorca, Spain
    Ther Drug Monit 31:743-5. 2009
    ..The role of rheumatoid factor (RF) as a cause of immunoassay interferences is well known...

Research Grants64

  1. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..Collagen-induced arthritis (CIA) susceptible HLA transgenic mice produce rheumatoid factor and anti-cyclic citrullinated peptide (CCP) antibodies similar to that in RA patients...
  2. Defining the molecular determinants of the threshold for autoimmune arthritis
    Lih Yun Hsu; Fiscal Year: 2013
    ..YYAA mice, like SKG mice, develop rheumatoid factor antibodies, but fail to develop autoimmune arthritis...
  3. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Veena Taneja; Fiscal Year: 2013
    ..Collagen-induced arthritis (CIA) susceptible HLA transgenic mice produce rheumatoid factor and anti-cyclic citrullinated peptide (CCP) antibodies similar to that in RA patients...
  4. Impact of smoking on immune response and arthritis in humanized mice
    Veena Taneja; Fiscal Year: 2011
    ..Collagen-induced arthritis (CIA) susceptible HLA transgenic mice produce rheumatoid factor and anti-cyclic citrullinated peptide antibodies (ACPA) similar to that in patients....
  5. Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized Mice
    Veena Taneja; Fiscal Year: 2012
    ..CIA susceptible HLA transgenic mice produce rheumatoid factor and anti-cyclic citrullinated peptide (CCP) antibodies similar to that in patients...
  6. Pre-BCR Function Selecting Novel B Cell Receptors in Chronic Lymphocytic Leukemia
    Kyoko Hayakawa; Fiscal Year: 2010
    ..Some years later, we (and others) showed that production of autoantibody rheumatoid factor was enriched in human CD5+ B-cells...
  7. Mechanisms of Autoimmune Activation and Regulation by Innate Immune Receptors
    Mark J Shlomchik; Fiscal Year: 2013
    ..Via collaboration, the Rothstein and Shlomchik labs previously demonstrated that activation of rheumatoid factor (RF)-specific B cells by their antigenic immune-complexes was greatly potentiated if chromatin was contained ..
  8. Family History, Genes, Environment and G X E Interaction in Predicting RA Risk
    Elizabeth W Karlson; Fiscal Year: 2013
    ..in predicting immune phenotypes of RA: RA with and without CCP antibodies (CCP?), and RA with and without rheumatoid factor antibodies (RF?);and 2c: Apply this comprehensive risk model to RA cases and controls and to subsets of RA ..
  9. Impact of genetic variation TLR/CD14 pathways and smoking in RA
    TED RICHARD MIKULS; Fiscal Year: 2011
    ..RA- specific outcomes that will be examined include radiographic measures (modified Sharp score), rheumatoid factor (RF), anti-cyclic citrullinated peptide (CCP) antibody, and extra-articular disease (nodules and lung ..
  10. Immune complexes: origins and effects in HCV infection
    Lynn B Dustin; Fiscal Year: 2013
    ..We found that patients with MC have clonal or oligoclonal expansions of B cells expressing rheumatoid factor (RF)-like IgM, frequently encoded by VH1-69, JH4, and V:3-20 Ig gene segments...
  11. Activation and regulation of autoreactive B cells in health and disease
    Mark J Shlomchik; Fiscal Year: 2012
    ..We have been using the AM14 rheumatoid factor (RF) Ig transgenic mouse system to investigate the regulation of autoreactive B cells in normal and disease ..
  12. B Cell Development Defects in Murine Lupus
    Laurence Morel; Fiscal Year: 2013
    ..We will use immunoglobulin HC transgenes, rheumatoid factor (RF) AM14, anti-DNA 56R, and anti-phosphorycholine (PC) M167 as a control, to track the fate of autoreactive ..
  13. The Pathogenesis of Autoimmunity in Hepatitis C Virus Infection
    Edgar D Charles; Fiscal Year: 2012
    ..In HCV MC, the cryoglobulins usually contain a monoclonal immunoglobulin (Ig) M rheumatoid factor (RF) associated with polyclonal IgG...
  14. Mechanisms of B-Cell Tolerance in a Mouse Model of Lupus
    Allison Sang; Fiscal Year: 2013
    ..In this system, the AM14 rheumatoid factor (RF) binds exclusively to IgG2aa and not IgG2ab antibodies...
  15. Defining the complex genetics of JIA
    Susan D Thompson; Fiscal Year: 2010
    ..The two most common subtypes, and the focus of this study, are the oligoarticular and IgM rheumatoid factor negative (RF-) polyarticular forms of JIA...
  16. IL-4 Signaling Pathway Regulation of Sjogren's Syndrome
    AMMON PECK; Fiscal Year: 2004
    ..syndrome includes detection of leukocytic infiltrates in the minor salivary glands, the presence of rheumatoid factor, hypergammaglobulinemia, specific anti-nuclear autoantibodies, loss of stimulated fluid secretion, and ..
  17. HEPATITIS C VIRUS IN ETIOLOGY OF WA RHEUMATOID FACTORS
    Vincent Agnello; Fiscal Year: 2001
    ..It is postulated from this hypothesis that initially a WA+ RF- IgM is produced and that rheumatoid factor activity arises as a result of a point mutation in the CDR3 with chronic HCV infection...
  18. RHEUMATOID ARTHRITIS
    C Kwoh; Fiscal Year: 1993
    ..of family members will be verified using a detailed structured history and physical examination, and serum rheumatoid factor testing...
  19. HEPATITIS C AND CRYOGLOBULINEMIA
    Warren Schmidt; Fiscal Year: 1999
    ..The hallmark of EMC is the appearance of cold insoluble globulins with Rheumatoid Factor (RF) and cryoprecipitates...
  20. M3 RECEPTOR: DIAGNOSTIC MARKER FOR SJOGREN'S SYNDROME
    MICHAEL HUMPHREYS BEHER; Fiscal Year: 2000
    ..detection of lymphocytic infiltrates in biopsies of the labial glands, the presence of autoantibodies to rheumatoid factor and cellular components (e.g...
  21. Treatment of Early Aggressive Rheumatoid Arthritis TEAR
    Larry Moreland; Fiscal Year: 2001
    ..clinical phenotype defined by presence of erosions on hand or feet radiographs, or positive serum rheumatoid factor, plus active synovitis of multiple joints...
  22. RHEUMATOID ARTHRITIS, 1993
    Edward Harris; Fiscal Year: 1993
    ..tentatively Zurier and Lewis), "Cytokines and their Inhibitors" (Amento and Dingle), "B Cell Activation and Rheumatoid Factor" (Lipsky), "Overview on Rheumatoid Factor" (Natvig), "The Proliferative Lesion of Rheumatoid Arthritis ..
  23. Dys/Regulation of the Immune System in Autoimmunity
    Richard Flavell; Fiscal Year: 2006
    ..mouse models will be used to study the regulation of B cells expressing a disease- related autoantibody, rheumatoid factor (RF), in normal and autoimmune mice...
  24. HUMORAL ANTIBODIES ACCOMPANYING HOMOGRAFTS
    Boris Albini; Fiscal Year: 1990
    ..This study will be primarily preoccupied with detection of IgG rheumatoid factor, but also studies will be continued on heterophile transplantation antibodies and antibodies to Wassermann-..
  25. Activation and Regulation of Rheumatoid Factor B cells
    Mark Shlomchik; Fiscal Year: 2002
    ..abstract_text> ..
  26. NEW MODALITIES FOR ACTIVE IMMUNOTHERAPY OF MALIGNANCIES
    Thomas Kipps; Fiscal Year: 1993
    ..3) investigate modalities of active immunotherapy for a transplantable murine B cell hybridoma expressing rheumatoid factor (RF) encoded by murine Ig variable region genes (V genes) that have not diversified substantially from the ..
  27. Testing in Vivo Roles of TLRs in Systemic Autoimmunity
    Mark Shlomchik; Fiscal Year: 2004
    ..Recently, it was demonstrated by the Rothstein and Shlomchik labs that activation of rheumatoid factor (RF)-specific B cells by their antigenic immune-complexes was greatly potentiated if chromatin was contained ..
  28. INHIBITION OF IL-6 AND STAT3 IN RHEUMATOID ARTHRITIS
    Lionel Ivashkiv; Fiscal Year: 1999
    ..been clarified, but potential mechanisms include activation of macrophages, stimulation of local antibody (rheumatoid factor) production, activation of T cells, and stimulation of myeloid and fibroblast differentiation into cells ..
  29. VARIABLE REGION GENE EXPRESSION IN HUMAN AUTOANTIBODIES
    Gregg Silverman; Fiscal Year: 1992
    ..Monoclonal IgM paraproteins with rheumatoid factor (RF) activity have been shown to preferentially use germline encoded light chains of the kappa III subgroup...
  30. TLR/BCR Synergy in an Autoreactive B Cell Activation
    Ann Marshak Rothstein; Fiscal Year: 2003
    ..However, these rheumatoid factor (RF) producing B cells proliferate vigorously in response to IC consisting of IgG2a bound to chromatin (..
  31. M3 Receptor--Diagnostic Marker for Sjogren's Syndrome
    AMMON PECK; Fiscal Year: 2003
    ..syndrome involves detection of lymphocytic infiltrates in biopsies of the labial glands; the presence of rheumatoid factor, serum antibodies reactive with cellular components (e.g...
  32. ORIGIN OF RHEUMATOID FACTORS
    JAN HILLSON; Fiscal Year: 1993
    ..The approach will be establish immortalized rheumatoid factor secreting cell lines from four populations: newly emerging lymphocytes from fetal liver; corresponding fetal ..
  33. HIV AND CMV RETINITIS
    Jay Pepose; Fiscal Year: 1992
    ..of these tests will be correlated with death-to-cardiac puncture time, degree of hemolysis, presence of rheumatoid factor and the use of serum separators...
  34. GENETIC CONTROL OF AUTOIMMUNITY
    Martin Weigert; Fiscal Year: 1999
    ..Thus, there must be an active mechanism for maintaining self-tolerance. Our studies using anti-DNA and Rheumatoid Factor transgenics revealed several mechanisms by which autoantibodies were regulated, namely, deletion, anergy and ..
  35. IMMUNOPATHOLOGIC STUDIES
    FRANK DIXON; Fiscal Year: 1990
    ..Third, an analysis of rheumatoid factor (RF) by serologic and structural studies at the clonal level will be undertaken in an effort to define the ..
  36. MOLECULAR GENETIC BASIS OF RF IN RA
    Dick Robbins; Fiscal Year: 1993
    ..of this research project is to better define and characterize the molecular genetic basis and uniqueness of rheumatoid factor (RF) expression in rheumatoid arthritis (RA)...
  37. ROLE OF CD30: CD153-PATHOGENESIS OF RHEUMATOID ARTHRITIS
    Andrea Cerutti; Fiscal Year: 2003
    ..display increased levels of synovial soluble CD3O that positively correlate with the levels of circulating rheumatoid factor as well as with the disease activity...
  38. ROLE OF RF-LIKE IGM IN RESISTANCE TO MALARIA
    REUEL HOOK; Fiscal Year: 1991
    DESCRIPTION (Adapted from the Applicant's Abstract): Although rheumatoid factor-like IgM (Rf-like) has been demonstrated to augment the effect of parasite-specific IgG in vitro, the in vivo role of RF-like IgM in parasite is less clear...
  39. HUMAN ANTIBODY DIVERSITY IN HEALTH & AUTOIMMUNITY
    Thomas Kipps; Fiscal Year: 1990
    ..gene expression, the relationship between isotype switching and V gene somatic mutation, the association of rheumatoid factor activity with major cross reactive idiotypic determinants...
  40. Estrogenic Regulation of Inflammation Related to TMJD
    Phillip Kramer; Fiscal Year: 2006
    ..Fc gamma RIIIA is a receptor that selectively binds IgG molecules, an important rheumatoid factor (RF) in auto-immune disease...
  41. HLA-D AND IA-LIKE ANTIGENS IN RHEUMATOID ARTHRITIS
    Peter Stastny; Fiscal Year: 1980
    ..haplotypes, but not having developed the disease, will be investigated to determine whether they produce rheumatoid factor. In addition, their immune response to Epstein-Barr virus-determined antigens will be studied...
  42. ROLE OF RHEUMATOID FACTOR IN IMMUNOREGULATION
    Monte Hobbs; Fiscal Year: 1990
    In humans, increases in rheumatoid factor (RF) production are associated with rheumatoid arthritis (RA) and other autoimmune syndromes, chronic viral and bacterial infections, and secondary antigen challenge...
  43. NATURAL IGM AND IMMUNITY AND AUTOIMMUNITY
    Jianzhu Chen; Fiscal Year: 1999
    ..Autoantibodies, including IgM rheumatoid factor, are often associated with human rheumatoid disease...
  44. MECHANISM OF AUTOREACTIVITY IN SLE
    Robert Eisenberg; Fiscal Year: 2001
    ..are more prominent in the congenic lpr mice; for example, C57BL/6-lpr mice produce higher levels of IgM rheumatoid factor with specificity for IgG2b than do MRL/lpr mice...
  45. THE IMMUNE RESPONSE IN HUMAN AUTOIMMUNE DISEASES
    Robert Fox; Fiscal Year: 1991
    ..b>Rheumatoid factor (anti-IgG) in the sera of SS patients contains a cross reactive idiotype (CRI) defined by a monoclonal ..
  46. PATHOGENIC AUTOREACTIVE T CELLS IN MURINE AUTOIMMUNITY
    Ian Rifkin; Fiscal Year: 2002
    ..these adoptive transfer experiments; in additional to conventional antigen presenting cells (APC), rheumatoid factor expressing transgenic B cells pulsed with immune complexes will be used as a source of APC; 2) developing a ..
  47. Human TNFa-Induced Pre-B Cell Bone Marrow Emigrants
    MARC LEVESQUE; Fiscal Year: 2007
    ..the administration of agents that neutralize TNFa promotes resolution of clinical symptoms and reductions in rheumatoid factor production...
  48. PATHOGENETIC ROLE OF RF COMPLEMENT IN ARTHRITIS
    Dick Robbins; Fiscal Year: 1980
    The purpose of this research project is to attempt to better understand the pathogenetic role of rheumatoid factor and complement in the inflammatory process producing tissue damage in rheumatoid arthritis...
  49. Role of the MHC Class II tranactivator gene in lupus and rheumatoid arthritis
    PAOLA GRASSO BRONSON; Fiscal Year: 2010
    ..Associations with specific RA phenotypes (rheumatoid factor (RF), anti-cyclic citrullinated peptide (anti-CCP) positivity, and erosive disease) in the RA families will ..
  50. Gene-Environment Interactions in RA Autoimmunity and Disease Severity
    Ted Mikuls; Fiscal Year: 2009
    ..RA-specific outcomes that will be examined include radiographic measures (modified Sharp score), nodules, rheumatoid factor (RF), and anti-cyclic citrullinated peptide (CCP) antibody...
  51. CELLULAR CONTROL OF EB VIRUS IN RHEUMATOID ARTHRITIS
    HARRY BLUESTEIN; Fiscal Year: 1990
    ..While EBV infection is not likely to be the initiating event in RA, it may, by virtue of its ability to modulate immune responses and enhance rheumatoid factor production, play a role in the perpetuation of the disease.
  52. BIOCHEMISTRY OF B LYMPHOCYTE NEGATIVE SIGNALING
    KENNETH COGGESHALL; Fiscal Year: 1999
    ..Furthermore, rheumatoid factor, an IgM anti-IgG Fc antibody, can block negative signaling by interfering with the binding secreted Ig with ..