anticardiolipin antibodies

Summary

Summary: Antiphospholipid antibodies found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. The antibodies are detected by solid-phase IMMUNOASSAY employing the purified phospholipid antigen CARDIOLIPIN.

Top Publications

  1. pmc Anticardiolipin antibodies in patients with chronic hepatitis C virus infection: characterization in relation to antiphospholipid syndrome
    J Ordi-Ros
    Department of Internal Medicine, Vall d Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Clin Diagn Lab Immunol 7:241-4. 2000
  2. ncbi Estimation of anticardiolipin antibodies, anti-beta2 glycoprotein I antibodies and lupus anticoagulant in a prospective longitudinal study of children with juvenile idiopathic arthritis
    T Avcin
    Department of Pediatrics, University Medical Center, Ljubljana, Slovenia
    Clin Exp Rheumatol 20:101-8. 2002
  3. ncbi Complement-fixing activity of anticardiolipin antibodies in patients with and without thrombosis
    M M Shinzato
    Division of Rheumatology, University of Sao Paulo, Brazil
    Lupus 14:953-8. 2005
  4. pmc Autoantibody profile in rheumatoid arthritis during long-term infliximab treatment
    Francesca Bobbio-Pallavicini
    Department of Rheumatology University of Pavia, IRCCS Policlinico S, Matteo, Pavia, Italy
    Arthritis Res Ther 6:R264-72. 2004
  5. pmc Anticardiolipin antibodies in patients with multiple sclerosis do not represent a subgroup of patients according to clinical, familial, and biological characteristics
    O Heinzlef
    Department of Neurology, Tenon Hospital, 4 rue de la Chine, 75020 Paris, France
    J Neurol Neurosurg Psychiatry 72:647-9. 2002
  6. ncbi Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome
    YOSHITSUGI HOKAMA
    Department of Pathology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    J Clin Lab Anal 23:210-2. 2009
  7. ncbi Clinical manifestations and vascular events in patients with lupus erythematosus anticardiolipin antibodies and raynaud's phenomenon
    Vanessa E Rodriguez
    Rheumatology Section, Department of Internal Medicine, University of Puerto Rico School of Medicine, Sun Juan 00936 5067
    P R Health Sci J 25:307-13. 2006
  8. ncbi IgG and IgM anticardiolipin antibodies following treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis
    Sudha Visvanathan
    Centocor, Inc, Malvern, Pennsylvania 19355, USA
    Arthritis Rheum 54:2840-4. 2006
  9. ncbi Anticardiolipin antibodies from patients with the antiphospholipid antibody syndrome recognize epitopes in both beta(2)-glycoprotein 1 and oxidized low-density lipoprotein
    S Horkko
    Department of Medicine, University of California, San Diego, USA
    Circulation 103:941-6. 2001
  10. ncbi Neonatal cerebral ischaemia with elevated maternal and infant anticardiolipin antibodies
    G Chow
    Department of Paediatric Neurology, Queen s Medical Centre, Nottingham, UK
    Dev Med Child Neurol 42:412-3. 2000

Research Grants

  1. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
  2. ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDS
    Joseph Witztum; Fiscal Year: 2004
  3. ANTIPHOSPHOLIPID ANTIBODIES IN THROMBOSIS
    Reginald Chukwuocha; Fiscal Year: 2000
  4. ANTICARDIOLIPIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROME
    Pojen Chen; Fiscal Year: 2007
  5. RESEARCH TRAINING IN BLOOD AND VASCULAR BIOLOGY
    Sandor Shapiro; Fiscal Year: 1999
  6. Epidemiology of Venous Thromboembolism
    Robert Glynn; Fiscal Year: 2004
  7. Safety of Estrogen in Lupus Erythematosus
    Jill Buyon; Fiscal Year: 2004
  8. AUTOIMMUNE MECHANISMS OF THROMBOSIS
    Robert Roubey; Fiscal Year: 2004
  9. Reduction of Annexin A5 in Antipholipid Pregnancy Loss
    JACOB RAND; Fiscal Year: 2010
  10. Cognitive Function in SLE (COGNITION)
    Robin L Brey; Fiscal Year: 2010

Detail Information

Publications232 found, 100 shown here

  1. pmc Anticardiolipin antibodies in patients with chronic hepatitis C virus infection: characterization in relation to antiphospholipid syndrome
    J Ordi-Ros
    Department of Internal Medicine, Vall d Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain
    Clin Diagn Lab Immunol 7:241-4. 2000
    ..Finally, no cross-reactivity between aCL antibodies and HCV antigens was observed. As previously reported, aCL antibodies seem to be an epiphenomenon, and they do not have clinical or laboratory significance in HCV patients...
  2. ncbi Estimation of anticardiolipin antibodies, anti-beta2 glycoprotein I antibodies and lupus anticoagulant in a prospective longitudinal study of children with juvenile idiopathic arthritis
    T Avcin
    Department of Pediatrics, University Medical Center, Ljubljana, Slovenia
    Clin Exp Rheumatol 20:101-8. 2002
    b>Anticardiolipin antibodies (aCL) have been frequently detected in juvenile idiopathic arthritis (JIA), but have not been associated with disease activity or clinical features of the antiphospholipid syndrome (APS)...
  3. ncbi Complement-fixing activity of anticardiolipin antibodies in patients with and without thrombosis
    M M Shinzato
    Division of Rheumatology, University of Sao Paulo, Brazil
    Lupus 14:953-8. 2005
    We have analysed in vitro the complement-fixing activity of anticardiolipin antibodies (C-fix aCL) from patients with persistent and moderate/high titres IgG aCL antibodies: 21 with thrombosis and 11 without thrombosis...
  4. pmc Autoantibody profile in rheumatoid arthritis during long-term infliximab treatment
    Francesca Bobbio-Pallavicini
    Department of Rheumatology University of Pavia, IRCCS Policlinico S, Matteo, Pavia, Italy
    Arthritis Res Ther 6:R264-72. 2004
    ..DNA antibodies is a transient phenomenon, despite a stable increase in antinuclear and anticardiolipin antibodies. Also, the evolution of RF titres and that of anti-CCP antibody titres differed during long-term ..
  5. pmc Anticardiolipin antibodies in patients with multiple sclerosis do not represent a subgroup of patients according to clinical, familial, and biological characteristics
    O Heinzlef
    Department of Neurology, Tenon Hospital, 4 rue de la Chine, 75020 Paris, France
    J Neurol Neurosurg Psychiatry 72:647-9. 2002
    In multiple sclerosis (MS), case control studies have shown that anticardiolipin antibodies (aCL Ab) are more frequent than in the general population and that aCL Ab positivity may be associated with specific clinical characteristics.
  6. ncbi Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome
    YOSHITSUGI HOKAMA
    Department of Pathology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA
    J Clin Lab Anal 23:210-2. 2009
    Examination of anticardiolipin antibodies (ACAs) in the sera of patients clinically diagnosed with chronic fatigue syndrome (CFS) using an enzyme-linked immunoassay procedure demonstrated the presence of immunoglobulin M isotypes in 95% ..
  7. ncbi Clinical manifestations and vascular events in patients with lupus erythematosus anticardiolipin antibodies and raynaud's phenomenon
    Vanessa E Rodriguez
    Rheumatology Section, Department of Internal Medicine, University of Puerto Rico School of Medicine, Sun Juan 00936 5067
    P R Health Sci J 25:307-13. 2006
    Raynaud's phenomenon (RP) and anticardiolipin antibodies (ACL) are two common clinical manifestations in patients with systemic lupus erythematosus (SLE). RP may lead to digital or limb loss. ACL are associated to thrombotic episodes...
  8. ncbi IgG and IgM anticardiolipin antibodies following treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis
    Sudha Visvanathan
    Centocor, Inc, Malvern, Pennsylvania 19355, USA
    Arthritis Rheum 54:2840-4. 2006
    To assess the occurrence of anticardiolipin antibodies (aCL) in patients with early rheumatoid arthritis (RA) receiving treatment with infliximab plus methotrexate (MTX) versus MTX alone.
  9. ncbi Anticardiolipin antibodies from patients with the antiphospholipid antibody syndrome recognize epitopes in both beta(2)-glycoprotein 1 and oxidized low-density lipoprotein
    S Horkko
    Department of Medicine, University of California, San Diego, USA
    Circulation 103:941-6. 2001
    We recently suggested that many anticardiolipin antibodies bind only to oxidized cardiolipin (OxCL) and/or to OxCL-beta(2)-glycoprotein 1 (beta(2)GP1) adducts but not to a "reduced" cardiolipin that is unable to undergo oxidation...
  10. ncbi Neonatal cerebral ischaemia with elevated maternal and infant anticardiolipin antibodies
    G Chow
    Department of Paediatric Neurology, Queen s Medical Centre, Nottingham, UK
    Dev Med Child Neurol 42:412-3. 2000
    ..The baby's mother had raised IgG and IgM anticardiolipin antibodies and the baby had IgG anticardiolipin antibodies at the upper range of normal 4 days after delivery...
  11. ncbi Anticardiolipin antibodies in scleroderma
    Raymond J Enzenauer
    J Clin Rheumatol 12:324-6. 2006
  12. ncbi Prenatal transfer of anticardiolipin antibodies associated with fatal neonatal aortic thrombosis
    Jeremy Tuohy
    Department of Obstetrics and Gynaecology, Wellington School of Medicine, University of Otago, Wellington, New Zealand
    Aust N Z J Obstet Gynaecol 45:175-6. 2005
  13. ncbi Anticardiolipin antibodies in HIV infection are independently associated with antibodies to the membrane proximal external region of gp41 and with cell-associated HIV DNA and immune activation
    Valerie Martinez
    Laboratory of Cellular Immunology, UMR INSERM 543, Paris, France
    Clin Infect Dis 48:123-32. 2009
    ..The demonstration of in vitro cardiolipin reactivity with 2 human immunodeficiency virus (HIV)-specific, broadly neutralizing antibodies (2F5 and 4E10) has prompted reevaluation of autoimmune manifestations in HIV infection...
  14. ncbi Anticardiolipin antibodies in Hashimoto's disease
    O Osundeko
    Division of Endocrinology and Metabolism, Department of Medicine, Hahnemann University Hospital, Philadelphia, Pennsylvania 19102, USA
    Endocr Pract 7:181-3. 2001
    OBJECTIVE: To ascertain the presence and significance of anticardiolipin antibodies in patients with Hashimoto's disease. METHODS: We studied 19 patients (15 women and 4 men; age range, 26 to 79 years) with Hashimoto's disease...
  15. ncbi Anticardiolipin antibodies as a risk factor for venous thromboembolism in a population-based prospective study
    Shauna S Runchey
    Division of Epidemiology, School of Public Health, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55454 1015, USA
    Br J Haematol 119:1005-10. 2002
    b>Anticardiolipin antibodies, one of the family of 'antiphospholipid' antibodies, increase the risk of venous thromboembolism in the presence of autoimmune disease...
  16. pmc A case of multiple sclerosis associated with rheumatoid arthritis and positive anticardiolipin antibodies
    S Mpofu
    Ann Rheum Dis 62:376. 2003
  17. ncbi Anticardiolipin antibodies in hemodialysis patients with hepatitis C and their role in fistula failure
    S Ozmen
    Department of Nephrology, Dicle University School of Medicine, Diyarbakir, Turkey
    Clin Nephrol 72:193-8. 2009
    Several conflicting results are presently reported regarding raised IgG and IgM-anticardiolipin antibodies (ACA) titers in hemodialysis (HD) patients and their role in vascular access dysfunction...
  18. ncbi Malignant atrophic papulosis: endocardial involvement and positive anticardiolipin antibodies
    E Saglik
    J Eur Acad Dermatol Venereol 20:602-3. 2006
  19. ncbi Enhancement of human platelet activation by the combination of low concentrations of collagen and rabbit anticardiolipin antibodies
    Lai Wang
    Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan
    Br J Haematol 118:1152-62. 2002
    Low concentrations of collagen and anticardiolipin antibodies (ACLA), which were raised in rabbits by immunization with cardiolipin (CL), co-operatively activated human gel-filtrated platelets (GFP)...
  20. ncbi Anticardiolipin antibodies during hormone replacement therapy in healthy postmenopausal women
    Maria Todorova
    Department of Pathophysiology, Medical University, Georgi Sofiiski Street 1, Sofia 1431, Bulgaria
    Maturitas 48:393-7. 2004
    ..The aim of the study was to investigate IgG and IgM anticardiolipin (aCL) antibodies in the course of hormone replacement therapy (HRT)...
  21. ncbi Anticardiolipin antibodies are not a useful screening tool in a nonselected large group of patients with multiple sclerosis
    J Sastre-Garriga
    , H. Universitari Vall d'Hebron, Barcelona, Spain
    Ann Neurol 49:408-11. 2001
    ..be clinically distinguished from multiple sclerosis (MS) recommend that MS patients be screened for anticardiolipin antibodies (ACA)...
  22. ncbi Neuropsychiatric lupus syndromes: relationship with antiphospholipid antibodies
    Antonella Afeltra
    University Campus Bio Medico, Rome, Italy
    Neurology 61:108-10. 2003
    ..Sixty-one consecutive SLE patients were studied. Neuropsychiatric manifestations consistent with the diagnosis of NPSLE occurred in 44 (72%). Patients with NPSLE showed significantly higher levels of anticardiolipin antibodies.
  23. ncbi A prospective study of anticardiolipin antibodies as a risk factor for venous thrombosis in a general population (the HUNT study)
    I A Naess
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    J Thromb Haemost 4:44-9. 2006
    ..Prethrombotic serum anticardiolipin antibodies were measured by an enzyme-linked immunoassay...
  24. ncbi High prevalence of anticardiolipin antibodies in patients with HCV-associated oral lichen planus
    Y Nagao
    Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume 830 0011, Japan
    Int J Mol Med 9:293-7. 2002
    ..In addition, anticardiolipin antibodies (aCL) and cryoglobulin have been demonstrated in chronic hepatitis C...
  25. ncbi A comparative audit of anticardiolipin antibodies in oligoclonal band negative and positive multiple sclerosis
    Janek Vilisaar
    University of Tartu, Tartu, Estonia
    Mult Scler 11:378-80. 2005
    It has been suggested that multiple sclerosis (MS) patients with positive anticardiolipin antibodies (ACLA) have some atypical features, including absent oligoclonal bands (OCB) in the cerebrospinal fluid (CSF)...
  26. pmc Increased thromboembolic incidence in anti-cardiolipin-positive patients with malignancy
    E Zuckerman
    Department of Internal Medicine A, Bnai Zion Medical Centre, Haifa, Israel
    Br J Cancer 72:447-51. 1995
    ..Patients with malignancies show an increased prevalence of ACLA. Furthermore, ACLA-positive patients, mainly those with high titres, are much more prone to thromboembolic events...
  27. ncbi Elevated IgA and IgM anticardiolipin antibodies in acute Kawasaki disease
    Monesha Gupta
    Division of Cardiology, Department of Pediatrics, New York Presbyterian Hospital, New York, N Y, USA
    Cardiology 97:180-2. 2002
    There is marked activation of the endothelium and immune system in Kawasaki disease. Anticardiolipin antibodies (aCL) can cause activation of the endothelium...
  28. ncbi Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature
    Monica Galli
    Division of Hematology, Ospedali Riuniti, Bergamo, Italy
    Blood 101:1827-32. 2003
    To formally establish the risk of lupus anticoagulants and anticardiolipin antibodies for arterial and venous thrombosis, we ran a MEDLINE search of the literature from 1988 to 2000...
  29. ncbi Neuropsychiatric manifestations in systemic lupus erythematosus: prevalence and association with antiphospholipid antibodies
    Giovanni Sanna
    Lupus Research Unit, The Rayne Institute, London, UK
    J Rheumatol 30:985-92. 2003
    ..Neuropsychometric testing was applied by a neuropsychologist. Univariate and multivariate statistical analyses were applied to evaluate the association bewteen NP manifestations, magnetic resonance imaging (MRI) abnormalities, and aPL...
  30. ncbi The role of aspirin versus aspirin and heparin in cases of recurrent abortions with raised anticardiolipin antibodies
    Neha Goel
    Department of Anatomy, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India
    Med Sci Monit 12:CR132-6. 2006
    The present study was undertaken to compare the role of aspirin versus aspirin plus heparin combination in pregnant women with poor obstetric history and raised anticardiolipin antibodies IgG (IgG(acl)).
  31. ncbi Anti-beta2 glycoprotein I and anticardiolipin antibodies in leptospirosis, syphilis and Kala-azar
    M Santiago
    Escola Bahiana de Medicina e Saúde Pública Hospital Santa Izabel, Bahia, Brazil
    Clin Exp Rheumatol 19:425-30. 2001
    ..The aim of the present study was determine the prevalence of antibodies to cardiolipin and to beta2GPI in patients with different infectious diseases, including leptospirosis, syphilis and leishmaniasis...
  32. ncbi Cross-reactivity of IgM and IgG anticardiolipin antibodies with oxidized-low density lipoproteins
    J Damoiseaux
    Department of Clinical and Experimental Immunology, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Ann N Y Acad Sci 1050:163-9. 2005
    b>Anticardiolipin antibodies (aCLAs) and antibodies to oxidized-low density lipoproteins (oxLDL) are associated with two distinct diseases: the antiphospholipid syndrome and atherosclerosis...
  33. pmc Cofactor dependence and isotype distribution of anticardiolipin antibodies in viral infections
    H Guglielmone
    Laboratorio de Análisis Clínicos Especializados LACE, Cordoba, Argentina
    Ann Rheum Dis 60:500-4. 2001
    ..Antibodies to cardiolipin (aCLs) are often detected in patients with autoimmune disorders or infectious diseases...
  34. ncbi Association between anticardiolipin antibodies and recurrent cardiac events in patients with acute coronary syndrome
    Adalet Gurlek
    Department of Cardiology, University of Ankara, Sihhiye, Ankara, Turkey
    Int Heart J 46:631-8. 2005
    ..These results suggest that 1) restenosis occurs more frequently in anticardiolipin positive patients and 2) no association is evident between positive aCL and mortality, reinfarction, and intracardiac thrombus...
  35. pmc Detection of 'antiphospholipid' antibodies: a single chromogenic assay of thrombin generation sensitively detects lupus anticoagulants, anticardiolipin antibodies, plus antibodies binding beta(2)-glycoprotein I and prothrombin
    Y Sheng
    Department of Medicine, St George Hospital, Kogarah and the University of New South Wales, Sydney, New South Wales, Australia
    Clin Exp Immunol 124:502-8. 2001
    ..All MoAbs binding beta(2)GPI showed inhibition of thrombin generation, while MoAbs binding domain I of beta(2)GPI had more LA effect...
  36. ncbi Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells
    S S Pierangeli
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
    Lupus 12:539-45. 2003
    ..Hence, the interplay between aPL antibodies and ECs is important inthe pathogenesis of thrombosis in APS...
  37. ncbi Frequent occurrence of anticardiolipin antibodies, Factor V Leiden mutation, and perturbed endothelial function in chronic myeloproliferative disorders
    Morten Krogh Jensen
    Department of Haematology, Rigshospitalet, University Hospital of Copenhagen, Denmark
    Am J Hematol 69:185-91. 2002
    ..b>Anticardiolipin antibodies of IgM subtype (median 38 U/mL, 33-99) were detected in 11 patients (22%) and only in one control (3%) (..
  38. ncbi Celiac disease associated with nodular regenerative hyperplasia, pulmonary abnormalities, and IgA anticardiolipin antibodies
    Eduardo Luiz R Cancado
    Department of Gastroenterology, University of Sao Paulo School of Medicine, Brazil Sao Paulo, Brazil
    J Clin Gastroenterol 40:135-9. 2006
    ..IgA anticardiolipin antibodies were reported recently in celiac patients with nodular regenerative hyperplasia...
  39. ncbi Behçet's disease with vascular involvement: the contribution of anticardiolipin antibodies and thrombomodulin
    H Nakano
    Division of Rheumatology and Allergy, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki, Japan
    Adv Exp Med Biol 528:395-8. 2003
  40. ncbi Longitudinal study of antinuclear and anticardiolipin antibodies in pregnant women with systemic lupus erythematosus and antiphospholipid syndrome
    Mario Salazar-Paramo
    Clinical Epidemiology Research Unit, Hospital de Especialidades, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social and Department of Physiology, CUCS, Universidad de Guadalajara, Guadalajara, Mexico
    Rheumatol Int 22:142-7. 2002
    The objective of this study was to perform a longitudinal follow-up of antinuclear antibodies (ANAs) and anticardiolipin antibodies titers (aCL) throughout pregnancy in a group of patients with systemic lupus erythematosus (SLE) and ..
  41. pmc The presence of multiple prothrombotic risk factors is associated with a higher risk of thrombosis in individuals with anticardiolipin antibodies
    Marie Hudson
    Division of Rheumatology, McGill University Health Centre, Montreal General Hospital, Montreal, Quebec, Canada
    J Rheumatol 30:2385-91. 2003
    To explore the effect of multiple prothrombotic risk factors in individuals with anticardiolipin antibodies (aCL), we evaluated immunologic, coagulation, and genetic prothrombotic abnormalities in a cohort of individuals with different ..
  42. ncbi Anticardiolipin antibodies in women with unexplained infertility
    L Radojcic
    Military Medical Academy, Department of Gynecology, Zemun, Serbia adn Montenegro
    Physiol Res 53:91-6. 2004
    ..4 %) compared to the fertile controls (18.5 %). Increased incidence of aCL and TgAt in infertile women supports the contention that these autoantibodies contribute to the infertility..
  43. ncbi Anticardiolipin antibodies in chronic hepatitis B and chronic hepatitis D infection, and hepatitis B-related hepatocellular carcinoma. Relationship with portal vein thrombosis
    Ioannis S Elefsiniotis
    Department of Hepatogastroenterology, University of Athens, Helena Venizelou Hospital, Athens, Greece
    Eur J Gastroenterol Hepatol 15:721-6. 2003
    To assess the presence of anticardiolipin antibodies (ACAs) in patients with chronic hepatitis B virus (HBV) infection, chronic hepatitis D virus (HDV) infection and HBV-related hepatocellular carcinoma (HCC) and to associate this with ..
  44. ncbi Anticardiolipin antibodies and risk of ischemic stroke and transient ischemic attack: the Framingham cohort and offspring study
    Vallabh Janardhan
    Department of Neurology, Boston University, Boston, Mass, USA
    Stroke 35:736-41. 2004
    The role of anticardiolipin antibodies (aCLs) as novel risk factors for ischemic stroke and transient ischemic attacks (TIAs) has been a matter of debate. Prior cohort studies included only selected subjects, mostly men...
  45. ncbi Digital skin necrosis in congenital afibrinogenaemia associated with hepatitis C virus infection, mixed cryoglobulinaemia and anticardiolipin antibodies
    Céline Girard
    Service de Dermatologie, CHU, Montpellier, France
    Acta Derm Venereol 85:56-9. 2005
    ..Laboratory investigations showed the presence of mixed cryoglobulinaemia and anticardiolipin antibodies. Resolution occurred with plasmapheresis...
  46. ncbi Evidence that anticardiolipin antibodies are independent risk factors for atherosclerotic vascular disease
    C J Glueck
    Cholesterol Center, Jewish Hospital, Cincinnati, Ohio 45229, USA
    Am J Cardiol 83:1490-4, A8. 1999
    Thrombophilic anticardiolipin antibodies (ACLAs) are independent risk factors for atherosclerotic vascular disease...
  47. ncbi Cardiolipin binding a light chain from lupus-prone mice
    B Pereira
    Department of Internal Medicine, University of Texas Health Science Center, Houston 77030, USA
    Biochemistry 37:1430-7. 1998
    ....
  48. pmc Anticardiolipin antibodies in patients with post-streptococcal reactive arthritis
    N Tamura
    Ann Rheum Dis 61:374. 2002
  49. ncbi Leukoencephalopathy and chronic pancreatitis as concomitant manifestations of systemic lupus erythematosus related to anticardiolipin antibodies
    J Swol-Ben
    Department of Surgery, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Rheumatol Int 24:177-81. 2004
    ..Leukoencephalopathy related to anticardiolipin antibodies in serum is a known but rare manifestation of SLE...
  50. pmc High prevalence of co-factor independent anticardiolipin antibodies in malaria exposed individuals
    P H Consigny
    Laboratoire de Parasitologie, UPRES 3234, Faculte de Medecine Pharmacie, Rouen, France
    Clin Exp Immunol 127:158-64. 2002
    b>Anticardiolipin antibodies (aCL) were investigated in 137 individuals chronically exposed to malaria and living in Africa and Asia...
  51. ncbi Anticardiolipin antibodies and mortality in patients with ischemic stroke: a prospective follow-up study
    David Tanne
    Detroit Medical Center Stroke Center, Wayne State University School of Medicine, Detroit, Mich, USA
    Neuroepidemiology 21:93-9. 2002
    The purpose of the present prospective observational study was to assess whether or not the presence of anticardiolipin antibodies (aCL) in unselected first ischemic stroke patients is associated with adverse outcome...
  52. ncbi Normalization of anticardiolipin antibodies following rituximab therapy for marginal zone lymphoma in a patient with Sjogren's syndrome
    K C Harner
    Rheumatology (Oxford) 43:1309-10. 2004
  53. ncbi Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus anticoagulant in patients with recurrent pregnancy loss
    K S D Kumar
    Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, India
    J Postgrad Med 48:5-10. 2002
    ..anticoagulant (LAC), venereal disease research laboratory test (VDRL) and Beta2-glycoprotein I dependent anticardiolipin antibodies Beta2 I aCL) in our cohort of population experiencing recurrent pregnancy loss (RPL) from Andhra Pradesh,..
  54. ncbi MRI findings in central nervous system systemic lupus erythematosus are associated with immunoserological parameters and hypertension
    Tunde Csepany
    Dept of Neurology, University of Debrecen, Nagyerdei krt 98, 4012, Debrecen, Hungary
    J Neurol 250:1348-54. 2003
    ..Immunoserological status was described by the presence of lupus anticoagulant (LA), and anticardiolipin antibodies (aCL)...
  55. pmc Treatment with tumour necrosis factor alpha antagonists in patients with rheumatoid arthritis induces anticardiolipin antibodies
    T Jonsdottir
    Department of Rheumatology, Karolinska University Hospital, Stockholm, Sweden
    Ann Rheum Dis 63:1075-8. 2004
    To determine the frequency and clinical impact of anticardiolipin antibodies (aCL) in patients with rheumatoid arthritis treated with infliximab and etanercept.
  56. ncbi High prevalence of anticardiolipin antibodies in patients with asymptomatic hepatitis C virus infection associated acute ischemic stroke
    Inimioara Mihaela Cojocaru
    Carol Davila University of Medicine and Pharmacy, Clinic of Neurology, Colentina Hospital, Bucharest, Romania
    Rom J Intern Med 43:89-95. 2005
    ..The purpose of this study was to investigate the prevalence of anticardiolipin antibodies in patients with asymptomatic chronic hepatitis C virus infection-related acute ischemic stroke...
  57. ncbi Clinical presentations and vascular histopathology in autopsied patients with systemic lupus erythematosus and anticardiolipin antibodies
    A Sipek-Dolnicar
    Department of Rheumatology, University Medical Centre, Ljubljana, Slovenia
    Clin Exp Rheumatol 20:335-42. 2002
    To examine histomorphological and immunohistological changes in an autopsy series of systemic lupus erythematosus (SLE) patients with or without anticardiolipin antibodies (aCL).
  58. ncbi IgA anticardiolipin antibodies--relation with other antiphospholipid antibodies and clinical significance
    A Selva-O'Callaghan
    Department of Internal Medicine, Hospital General Vall d Hebron, Spain
    Thromb Haemost 79:282-5. 1998
    ..To evaluate the usefulness of IgA antiphospholipid antibodies as markers of thrombosis and/or antiphospholipid antibody syndrome...
  59. ncbi Recurrent stroke and vascular events in elderly patients with anticardiolipin antibodies: a prospective study
    O Heinzlef
    Department of Neurology, Vasculaire Saint Antoine Hospital, Paris, France
    J Neurol 248:373-9. 2001
    The presence of anticardiolipin antibodies (aCL) is a recognized risk factor for ischaemic stroke and a predictor of recurrent ischaemic events in young patients, but the significance of positive aCL tests is uncertain in the elderly...
  60. ncbi beta(2)-Glycoprotein 1-dependent anticardiolipin antibodies and risk of ischemic stroke and myocardial infarction: the honolulu heart program
    R L Brey
    Division of Neurology, University of Texas Health Science Center at San Antonio, Texas, USA
    Stroke 32:1701-6. 2001
    ..8 (95% CI 1.2 to 2.6) at 15 years and 1.5 (95% CI 1.1 to 2.1) at 20 years. CONCLUSIONS: These data suggest that aCL IgG, particularly the beta2GP1-dependent variety, is an important predictor of future stroke and MI in men...
  61. ncbi Ocular features associated with anticardiolipin antibodies: a descriptive study
    E Miserocchi
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Uveitis and Immunology Service, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 131:451-6. 2001
    PURPOSE: To evaluate ocular features in patients presenting with inflammation in the presence of anticardiolipin antibodies. METHODS: A descriptive study of 13 patients presenting with idiopathic ocular inflammation involving anterior and ..
  62. ncbi Anticardiolipin antibody assay: a methodological analysis for a better consensus in routine determinations--a cooperative project of the European Antiphospholipid Forum
    A Tincani
    Clinical Immunology Unit, Brescia Hospital, Italy
    Thromb Haemost 86:575-83. 2001
    ..Our data show that aCL ELISA standardization is necessary in order to obtain comparable results in different laboratories...
  63. ncbi Beta2-glycoprotein I-dependent anticardiolipin antibodies preferentially bind the amino terminal domain of beta2-glycoprotein I
    P A McNeeley
    La Jolla Pharmaceutical Company, San Diego, CA 92121, USA
    Thromb Haemost 86:590-5. 2001
    ..Thus, analysis of serum samples from a large cohort of APS patients indicates that the immunodominant binding epitope(s) for anti-beta2 antibodies are localized to the amino terminal domain of beta2-GPI...
  64. ncbi Anticardiolipin antibodies in South African patients with lupus nephritis: a clinical and renal pathological study
    I P Naiker
    Renal Unit, King Edward VIII Hospital, Durban, South Africa
    Am J Nephrol 20:351-7. 2000
    This study was conducted prospectively to ascertain the prevalence of anticardiolipin antibodies (ACAs) in patients with lupus nephritis and to determine whether this subgroup of patients differed clinically and histologically from ..
  65. ncbi Transiently positive anticardiolipin antibodies and risk of thrombosis in patients with systemic lupus erythematosus
    Agustin Martinez-Berriotxoa
    Service of Internal Medicine, Hospital de Cruces, Universidad del Pais Vasco Euskal Herriko Unibertsitatea, Bizkaia, The Basque Country, Spain
    Lupus 16:810-6. 2007
    Fluctuations in the titers of anticardiolipin antibodies (aCL) have been reported in systemic lupus erythematosus (SLE) patients, but their relation with thrombosis is not completely understood...
  66. ncbi Prevalence and clinical significance of anticardiolipin antibodies in patients with type 1 autoimmune hepatitis
    Christos Liaskos
    Research Laboratory of Internal Medicine, Department of Medicine, Medical School, University of Thessaly, Larissa, Greece
    J Autoimmun 24:251-60. 2005
    There are few case reports on the association between autoimmune hepatitis (AIH) and anticardiolipin antibodies (anti-CLAbs) and/or antiphospholipid syndrome (APLS). We studied the anti-CLAbs prevalence in AIH and other hepatic diseases...
  67. ncbi Anticardiolipin antibodies and ocular disease
    Filipe Vieira Lima Cabrita
    Massachusetts Eye Research and Surgery Institute MERSI, Cambridge, MA 02142, USA
    Ocul Immunol Inflamm 13:265-70. 2005
    This paper reviews anticardiolipin antibodies and ocular disease. Its aim is to present the latest knowledge regarding the relationship between the two...
  68. ncbi Prevalence of anticardiolipin antibodies in peripheral arterial thrombosis
    J M de Godoy
    Department of Cardiology and Vascular Surgery, Sao Jose do Rio Preto University School of Medicine, Sao Paulo, Brasil
    Angiology 51:473-7. 2000
    The aim of this study was to assess prospectively the prevalence of anticardiolipin antibodies in patients with peripheral arterial thrombosis...
  69. ncbi Association of anticardiolipin antibodies levels with instent restenosis in patients with coronary artery disease
    Sumali Sharma
    Department of Physiology, Govt Medical College, Chandigarh 160 012
    Indian J Physiol Pharmacol 52:288-92. 2008
    Present study was conducted to evaluate the association of IgG anticardiolipin antibodies with instent restenosis in patients having undergone percutaneous intervention with bare metal or drug eluting stents...
  70. ncbi No excess of factor V:Q506 genotype but high prevalence of anticardiolipin antibodies without antiendothelial cell antibodies in retinal vein occlusion in young patients
    J A Scott
    Department of Ophthalmology, University of Aberdeen and Aberdeen Royal Infirmary, Aberdeen, UK
    Ophthalmologica 215:217-21. 2001
    ..b>Anticardiolipin antibodies (ACA), also associated with RVO, are a marker for the prothrombotic condition antiphospholipid syndrome, ..
  71. ncbi Lipoprotein (a) and anticardiolipin antibodies are risk factors for clinically relevant restenosis after elective balloon percutaneous transluminal coronary angioplasty
    L Chiarugi
    Istituto di Clinica Medica Generale e Cardiologia, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Atherosclerosis 154:129-35. 2001
    ..We investigated the relationship between Lp(a), fibrinolytic parameters and anticardiolipin antibodies (aCL) and the occurrence of clinical recurrence owing to restenosis after elective balloon percutaneous ..
  72. ncbi Aspirin reduces anticardiolipin antibodies in patients with coronary artery disease
    I Ikonomidis
    Second Cardiology Department, Attikon University Hospital, University of Athens, N Chalkidona, Athens, Greece
    Eur J Clin Invest 36:839-43. 2006
    b>Anticardiolipin antibodies (aCL) have been found to be elevated in patients with coronary artery disease (CAD) and have been associated with an adverse outcome owing to their prothrombotic activity...
  73. ncbi Anticardiolipin antibodies are frequently present in patients with idiopathic intracranial hypertension
    R R Leker
    Department of Neurology, Hebrew University, Hadassah University Medical Center, Jerusalem, Israel
    Arch Neurol 55:817-20. 1998
    b>Anticardiolipin antibodies (ACL-Ab) are associated with various neurologic syndromes, but idiopathic intracranial hypertension (IIH) has only rarely been reported in this context.
  74. ncbi Anticardiolipin antibodies in children with insulin-dependent diabetes mellitus
    Soad M Mohamed
    Department of Paediatrics and Clinical Pathology, Faculty of Medicine, Alexandria University, Egypt
    Metabolism 51:1148-52. 2002
    ..The current investigation was performed to determine the prevalence of IgG and IgM anticardiolipin antibodies in 2 groups of children with type 1 IDDM and to find a relation, if any, with the control and duration ..
  75. ncbi Limited effect of rituximab on thrombocytopaenia and anticardiolipin antibodies in a patient with primary antiphospholipid syndrome
    P R J Ames
    Ann Hematol 86:227-8. 2007
  76. ncbi Clinical significance of antinuclear antibodies, anti-neutrophil cytoplasmic antibodies and anticardiolipin antibodies in heroin abusers
    Milena Nikolova
    Nephrology Clinic, Department of Internal Medicine, University Alexandrovska Hospital, Faculty of Medicine, Sofia, Bulgaria
    Isr Med Assoc J 4:908-10. 2002
    ..Different autoantibodies and immunologic abnormalities have been described in heroin abusers positive for human immunodeficiency virus, hepatitis B surface antigen, or hepatitis C virus, as well as in addicts with negative viral markers...
  77. ncbi Clinical and immunogenetic characterization of Mexican patients with 'rhupus'
    J A Simon
    Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Tlalpan, CP, Mexico DF
    Lupus 11:287-92. 2002
    ..of the cases present thrombosis or morbidity during pregnancy in spite of presenting a high frequency of anticardiolipin antibodies. We also found an increased frequency of HLA-DR1 and HLA-DR2 alleles compared to healthy ethnically ..
  78. ncbi Thickened carotid artery intima-media in rheumatoid arthritis is associated with elevated anticardiolipin antibodies
    Y Sherer
    Department of Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Lupus 16:259-64. 2007
    ..Elevated levels of IgG anticardiolipin antibodies were detected in 17 of 82 (21%) RA patients, including 7 with medium-to-high levels considered being ..
  79. pmc Anticardiolipin antibodies in rheumatoid patients treated with etanercept or conventional combination therapy: direct and indirect evidence for a possible association with infections
    G Ferraccioli
    Chair and Division of Rheumatology, DPMSC, Udine University Medical Centre, University of Udine, 33100 Udine, Italy
    Ann Rheum Dis 61:358-61. 2002
    To assess the occurrence of anticardiolipin antibodies (ACA) (as well as of anti-DNA antibodies) in patients with rheumatoid arthritis treated with etanercept or combination therapy.
  80. ncbi Stroke in a young man with fibromuscular dysplasia of the cranial vessels with anticardiolipin antibodies: a case report
    M Tripathi
    Department of Neurology, CN Center, Ansari Nagar, New Delhi, India
    Neurol Sci 22:31-5. 2001
    ..Positivity of anticardiolipin antibodies suggested an immune response...
  81. ncbi Anticardiolipin antibodies in Behçet's disease: a reassessment
    S Tokay
    Department of Rheumatology, Faculty of Medicine, Marmara University, Istanbul, Turkey
    Rheumatology (Oxford) 40:192-5. 2001
    OBJECTIVE: To assess the frequency and clinical relevance of anticardiolipin antibodies (aCL) in Behçet's disease (BD)...
  82. ncbi Anticardiolipin antibodies in patients with primary antiphospholipid syndrome: a correlation between IgG titre and antibody-induced cell dysfunctions in neuronal cell cultures
    C Andreassi
    Institute of General Pathology, Catholic University, Rome, Italy
    Clin Rheumatol 20:314-8. 2001
    b>Anticardiolipin antibodies (aCL) of the immunoglobulin (Ig) G isotype have been significantly associated with neurological manifestations of antiphospholipid syndrome (APS)...
  83. ncbi V gene analysis of anticardiolipin antibodies from MRL-lpr/lpr mice
    Y Kita
    Second Department of Internal Medicine, School of Medicine, Chiba University, Japan
    J Immunol 151:849-56. 1993
    We analyzed the VH and V kappa genes of 14 hybridomas producing anticardiolipin antibodies (aCL) from MRL-lpr/lpr mice, in an attempt to address the question of whether aCL are generated by Ag-driven stimulation or by polyclonal B cell ..
  84. ncbi Presence of high avidity anticardiolipin antibodies in patients with autoimmune cholestatic liver diseases
    Kalliopi Zachou
    Department of Medicine, Research Laboratory of Internal Medicine, Medical School, University of Thessaly, Larissa, Greece
    Clin Immunol 119:203-12. 2006
    We studied the prevalence and clinical significance of anticardiolipin antibodies (aCL) in primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) as similar data are missing...
  85. ncbi Relationship of interleukin-12 and interleukin-13 imbalance with class-specific rheumatoid factors and anticardiolipin antibodies in systemic lupus erythematosus
    A Spadaro
    Dipartimento di Clinica e Terapia Medica Applicata, Universita di Roma La Sapienza, Azienda Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy
    Clin Rheumatol 22:107-11. 2003
    ..It was concluded that the increased levels of both IgM-RF and IgM-aCL in patients with prevalent Th2 activity suggest that the predominance of Th2 over Th1 could drive autoantibody production in SLE patients...
  86. pmc Association between microscopic brain damage as indicated by magnetization transfer imaging and anticardiolipin antibodies in neuropsychiatric lupus
    Stefan C A Steens
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Res Ther 8:R38. 2006
    The pathogenetic role of anticardiolipin antibodies (aCLs) in patients with neuropsychiatric systemic lupus erythematosus (NPSLE) without cerebral infarcts remains elusive...
  87. ncbi Clinical importance of positive test results for lupus anticoagulant and anticardiolipin antibodies
    Anne Proven
    Division of Rheumatology and Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 79:467-75. 2004
    To assess the performance of 4 clotting assays for lupus anticoagulant (LA) detection, to determine the prevalence of LA and anticardiolipin antibodies (aCL), and to correlate LA and aCL prevalence with systemic disease and thrombosis.
  88. ncbi Prevalence and clinical correlation of anti-phospholipid-binding protein antibodies in anticardiolipin-negative patients with systemic lupus erythematosus and women with unexplained recurrent miscarriages
    Nicola Bizzaro
    Laboratorio di Patologia Clinica, Ospedale di S Donà di Piave, Italy
    Arch Pathol Lab Med 129:61-8. 2005
    ..Anti-phospholipid antibodies (aPL) are a heterogeneous group of autoantibodies, the presence of which is associated with thrombotic events and miscarriage...
  89. ncbi [Anti-phospholipid antibody (aPL)]
    Moritaka Gotoh
    Department of Internal Medicine, Teikyo University School of Medicine
    Nihon Rinsho 62:687-90. 2004
  90. ncbi Use of a new silica clotting time for diagnosing lupus anticoagulant in patients who meet the clinical criteria for antiphospholipid syndrome
    Panagiotis Grypiotis
    Rheumatology Unit, University of Padova, Padova, Italy
    J Clin Lab Anal 20:15-8. 2006
    ..Moreover, the highest sensitivity was reached with a combination of SCT and dRVVT. The method's association with total thrombotic events and venous thrombosis was in fact significant...
  91. ncbi Antiphospholipid antibodies and antiphospholipid syndrome in 57 children and adolescents with systemic lupus erythematosus
    L M A Campos
    Paediatric Rheumatology Unit, Children s Institute, Hospital das Clinicas, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Lupus 12:820-6. 2003
    ..A negative association was observed between APS and the presence of anti-Ro antibodies...
  92. ncbi Antiphospholipid antibodies in young adults with stroke
    Robin L Brey
    University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284 7883, USA
    J Thromb Thrombolysis 20:105-12. 2005
    ..Antiphospholipid antibodies have been associated with a clinical syndrome consisting thrombosis and recurrent, unexplained fetal loss...
  93. pmc The persistence of anticardiolipin antibodies is associated with an increased risk of the presence of lupus anticoagulant and anti-beta2-glycoprotein I antibodies
    C Neville
    Division of Clinical Epidemiology, Montreal General Hospital, McGill University Health Centre, McGill University, Montreal, Quebec, Canada
    Rheumatology (Oxford) 45:1116-20. 2006
    ..from a cohort of individuals followed for thrombosis to determine whether the persistent presence of anticardiolipin antibodies (aCL) is associated with a greater likelihood of having lupus anticoagulant and/or anti-beta2-..
  94. pmc Anticardiolipin, anti-beta(2)-glycoprotein I and antiprothrombin antibodies in black South African patients with infectious disease
    S Loizou
    Lancet Laboratories, Johannesburg, South Africa
    Ann Rheum Dis 62:1106-11. 2003
    ..Unlike patients with systemic lupus erythematosus (SLE) and the antiphospholipid syndrome (APS), raised levels of aPL in infectious diseases are not usually associated with thrombotic complications...
  95. ncbi Antiphospholipid syndrome accompanied by a silent splenic infarct in a patient with juvenile SLE
    Tamas Constantin
    Rheumatol Int 26:951-2. 2006
  96. ncbi [Laboratory diagnosis of antiphospholipid syndrome]
    L Darnige
    Service d Hematologie Biologique, Hopital Europeen Georges Pompidou, 20 40, rue Leblanc, 75908 Paris Cedex 15, France
    Rev Med Interne 27:296-301. 2006
    ..e. lupus anticoagulant and/or anticardiolipin antibodies. This review focuses on the methods for antiphospholipid antibodies detection and their clinical ..
  97. ncbi Activated protein C resistance and lupus anticoagulant activity induced by plasma and purified monospecific human IgG anti-beta2-glycoprotein-I antibodies
    Martha E Viveros
    Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
    Rev Invest Clin 57:563-71. 2005
    ..We investigated the activated protein C resistance (APCR) phenotype and the lupus anticoagulant (LA), activity induced by anti-beta2-glycoprotein-I (anti-beta2GP-I) antibodies...
  98. ncbi Clinical significance of IgA anticardiolipin and anti-beta2-GP1 antibodies in patients with systemic lupus erythematosus and primary antiphospholipid syndrome
    M Samarkos
    5th Department of Internal Medicine, Evangelismos Hospital, 45 47 Ipsilantou Street, Athens, 106 76, Greece
    Clin Rheumatol 25:199-204. 2006
    The objectives of this study were to estimate the prevalence of IgA anticardiolipin antibodies (aCL) and anti-beta(2)-glycoprotein 1 antibodies (abeta(2)-GP1) in a large number of patients with systemic lupus erythematosus (SLE) and ..
  99. ncbi Identification of thrombin antibodies in patients with antiphospholipid syndrome
    Wolfgang Miesbach
    Johann Wolfgang Goethe University, Frankfurt Main Medical Clinic III, Theodor Stern Kai 7, 60590 Frankfurt Main, Germany
    Ann N Y Acad Sci 1050:250-6. 2005
    ..The sensitivity of the test for anti-thrombin antibodies for the diagnosis of APS was higher than the sensitivity of the anti-prothrombin assay and similar to the sensitivity of the anti-Ser/Pro assay...
  100. ncbi Epileptic seizures in systemic lupus erythematosus
    Simone Appenzeller
    Rheumatology Unit, Department of Internal Medicine, State University of Campinas, Brazil
    Neurology 63:1808-12. 2004
    ..To evaluate the frequency and risk factors of epileptic seizures in a large cohort of patients with systemic lupus erythematosus (SLE)...
  101. ncbi The association of thrombocytopenia with systemic manifestations in the antiphospholipid syndrome
    Ilan Krause
    Research Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Immunobiology 210:749-54. 2005
    ..Our data suggest the presence of thrombocytopenia may be a risk factor for cardiac, neurological, articular and cutaneous complications in APS...

Research Grants20

  1. Epidemiologic Study of Placental Abruption
    Cande Ananth; Fiscal Year: 2006
    ..test for acquired (and perhaps transitory) coagulation abnormalities such as lupus anticoagulant and anticardiolipin antibodies, as well as other heritable thrombophilias including protein C deficiency, activated protein C ..
  2. ANTICARDIOLIPIN ANTIBODIES AND OXIDIZED PHOSPHOLIPIDS
    Joseph Witztum; Fiscal Year: 2004
    ..g. aggressive anti-inflammatory and/or antioxidant interventions). ..
  3. ANTIPHOSPHOLIPID ANTIBODIES IN THROMBOSIS
    Reginald Chukwuocha; Fiscal Year: 2000
    ..syndrome", APS) in systemic lupus erythematous (SLE) are associated with the production of anticardiolipin antibodies (ACA) and lupus anticoagulant (LAC) activity...
  4. ANTICARDIOLIPIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROME
    Pojen Chen; Fiscal Year: 2007
    The long-term objectives of this project are to identify and characterize pathogenic anticardiolipin antibodies (aCL) in the antiphospholipid syndrome (APS)...
  5. RESEARCH TRAINING IN BLOOD AND VASCULAR BIOLOGY
    Sandor Shapiro; Fiscal Year: 1999
    ..of plasminogen activator inhibitor-l gene expression; mechanisms of action of lupus anticoagulants and anticardiolipin antibodies; erythropoietin function and gene expression; red cell structure and function in the hemoglobinopathies; ..
  6. Epidemiology of Venous Thromboembolism
    Robert Glynn; Fiscal Year: 2004
    ..risk including factor V Leiden, the G20210A mutation in the prothrombin gene, hyperhomocysteinemia, and anticardiolipin antibodies. The study will assess the joint association with risk of these markers and potentially modifiable ..
  7. Safety of Estrogen in Lupus Erythematosus
    Jill Buyon; Fiscal Year: 2004
    ..which may increase the risk for thrombosis even in patients screened out by virtue of high levels of anticardiolipin antibodies or a lupus anticoagulant...
  8. AUTOIMMUNE MECHANISMS OF THROMBOSIS
    Robert Roubey; Fiscal Year: 2004
    ..These data will be useful in focusing future research efforts on specific pathways of antibody-mediated monocyte activation and hypercoagulability and in designing new therapeutic strategies...
  9. Reduction of Annexin A5 in Antipholipid Pregnancy Loss
    JACOB RAND; Fiscal Year: 2010
    ....
  10. Cognitive Function in SLE (COGNITION)
    Robin L Brey; Fiscal Year: 2010
    ..The information that will be gained from this study is essential for the successful discovery of biological processes that impact on cognitive function in SLE that could be potentially amenable to disease-reversing therapies. ..
  11. Vasculitis Clinical Research Network (VCRN)
    Peter Merkel; Fiscal Year: 2008
    ..AIM 5. Build and contribute to an electronic website resource with substantive content for clinicians, researchers, and patients. ..
  12. Clinical Research for Rare Diseases: Opportunities, Challenges, and Solutions
    Peter Merkel; Fiscal Year: 2007
    ..If this conference proves successful, we plan on having similar sessions attached to future RDCRC meetings. [unreadable] [unreadable] [unreadable]..
  13. Cognitive dysfunction in neuropsychiatric-SLE
    Michael Lockshin; Fiscal Year: 2002
    ..Successful completion of this research will redefine the pathogenesis of cognitive dysfunction and suggest therapeutic targets for intervention...
  14. Brain Connections
    Michelle Petri; Fiscal Year: 2006
    ..abstract_text> ..
  15. Stroke:Role of aPL, hemostatic markers, and telestroke
    Steven Levine; Fiscal Year: 2006
    ....
  16. Revision of ACR Classification Criteria for Systemic Lupus Erythematosus
    Michelle Petri; Fiscal Year: 2007
    ..This project will lead to updated, validated SLE classification criteria that can be immediately used by both industry and academic clinical trials. ..
  17. Studies in Scleroderma and Cystic Fibrosis Osteoporosis
    Peter Merkel; Fiscal Year: 2005
    ..A unique seminar and a series of support services at the host institution will further complement the training program. ..
  18. MIDCAREER INVESTIGATOR AWARD IN PATIENT-ORIENTED RESEAR
    ROBIN BREY; Fiscal Year: 2006
    ..Much will be learned about the relative importance of genetic factors and autoantibodies on vascular disease risk in SLE that is likely to apply to other populations also at increased risk for cerebral ischemia and vascular dementia. ..
  19. PREDICTORS OF NEUROPSYCHIATRIC SLE
    ROBIN BREY; Fiscal Year: 2004
    ..The information gained will bridge important gaps in our knowledge about NS involvement in SLE and will lead to new hypothesis-driven studies of etiopathogenesis and treatment. ..