antinuclear antibodies

Summary

Summary: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.

Top Publications

  1. ncbi Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    Melissa R Arbuckle
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    N Engl J Med 349:1526-33. 2003
  2. ncbi Features of systemic lupus erythematosus in Dnase1-deficient mice
    M Napirei
    Abteilung für Anatomie und Embryologie, Medizinische Fakultat, Ruhr Universitat Bochum, Bochum, Germany
    Nat Genet 25:177-81. 2000
  3. ncbi Mutation of DNASE1 in people with systemic lupus erythematosus
    K Yasutomo
    Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima 770 8503, Japan
    Nat Genet 28:313-4. 2001
  4. ncbi Experimental and clinical significance of antinuclear antibodies in liver transplantation
    Toshiaki Nakano
    Department of Surgery, Liver Transplantation Program, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Transplantation 83:1122-5. 2007
  5. pmc Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
    Sean R Christensen
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 202:321-31. 2005
  6. pmc Cytokine-associated neutrophil extracellular traps and antinuclear antibodies in Plasmodium falciparum infected children under six years of age
    Virginia S Baker
    Department of Biological Science, Florida State University, Tallahassee, Florida, USA
    Malar J 7:41. 2008
  7. ncbi Role of antinuclear antibodies in experimental and clinical liver transplantation
    T Nakano
    Department of Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Transplant Proc 38:3605-6. 2006
  8. ncbi Detection of antinuclear antibodies by solid-phase immunoassays and immunofluorescence analysis
    Mogens Fenger
    Department of Clinical Biochemistry, University Hospital of Copenhagen, Hvidovre, Denmark
    Clin Chem 50:2141-7. 2004
  9. pmc Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies
    C Mohan
    Simmon s Arthritis Research Center, Center for Immunology, University of Texas Southwestern Medical School, Dallas 75235 8884, USA
    J Clin Invest 103:1685-95. 1999
  10. pmc Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells
    B A Cocca
    Department of Microbiology and Immunology, MCP Hahnemann University, Philadelphia, PA 19129, USA
    Proc Natl Acad Sci U S A 98:13826-31. 2001

Research Grants

  1. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
  2. The Role of Sex in Self Antigen Generation in SLE
    David Stephen Pisetsky; Fiscal Year: 2010
  3. MECHANISMS OF AUTOIMMUNITY IN SLE
    David Stephen Pisetsky; Fiscal Year: 2013
  4. Microparticles as a Source of Nuclear Antigens in Systemic Lupus Erythematosus
    David Stephen Pisetsky; Fiscal Year: 2010
  5. Development &validationof a panel of antibodies for the diagnosis of sarcoidosis
    Lobelia Samavati; Fiscal Year: 2013
  6. ANIMAL MODEL OF DRUG-INDUCED SLE
    David Aucoin; Fiscal Year: 1990
  7. HUMAN HYBRIDOMAS IN THE ANALYSIS OF AUTOIMMUNE DISEASE
    BERNARD STOLLAR; Fiscal Year: 1990
  8. EPIDEMIOLOGY OF RAYNAUD PHENOMENON
    HILDEGARD MARICQ; Fiscal Year: 1992
  9. NUCLEAR PROTEINS AND AUTOIMMUNITY
    SALLIE HOCH; Fiscal Year: 1992
  10. AUTOMATED, QUANTITATIVE IMMUNOFLUORESCENT ASSAY
    KENNETH NEWTON; Fiscal Year: 2003

Detail Information

Publications263 found, 100 shown here

  1. ncbi Development of autoantibodies before the clinical onset of systemic lupus erythematosus
    Melissa R Arbuckle
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    N Engl J Med 349:1526-33. 2003
    ..We investigated the onset and progression of autoantibody development before the clinical diagnosis...
  2. ncbi Features of systemic lupus erythematosus in Dnase1-deficient mice
    M Napirei
    Abteilung für Anatomie und Embryologie, Medizinische Fakultat, Ruhr Universitat Bochum, Bochum, Germany
    Nat Genet 25:177-81. 2000
    ..Our findings suggest that lack or reduction of Dnase1 is a critical factor in the initiation of human SLE...
  3. ncbi Mutation of DNASE1 in people with systemic lupus erythematosus
    K Yasutomo
    Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima 770 8503, Japan
    Nat Genet 28:313-4. 2001
    ..These data are consistent with the hypothesis that a direct connection exists between low activity of DNASE1 and progression of human SLE...
  4. ncbi Experimental and clinical significance of antinuclear antibodies in liver transplantation
    Toshiaki Nakano
    Department of Surgery, Liver Transplantation Program, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Transplantation 83:1122-5. 2007
    ..These results suggest that antinuclear Abs are important factors for overcoming rejection and the subsequent tolerance induction in liver transplantation...
  5. pmc Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
    Sean R Christensen
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 202:321-31. 2005
    ..These results demonstrate a specific requirement for TLR9 in autoantibody formation in vivo and indicate a critical role for innate immune activation in autoimmunity...
  6. pmc Cytokine-associated neutrophil extracellular traps and antinuclear antibodies in Plasmodium falciparum infected children under six years of age
    Virginia S Baker
    Department of Biological Science, Florida State University, Tallahassee, Florida, USA
    Malar J 7:41. 2008
    ..The presence of NETs and ANA to double-stranded DNA along with the cytokine profiles found suggests autoimmune mechanisms that could produce pathogenesis in children, but immunoprotection in adults...
  7. ncbi Role of antinuclear antibodies in experimental and clinical liver transplantation
    T Nakano
    Department of Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Kaohsiung, Taiwan
    Transplant Proc 38:3605-6. 2006
    ..The present study sought to evaluate the role of antinuclear Abs in experimental and clinical liver transplantation...
  8. ncbi Detection of antinuclear antibodies by solid-phase immunoassays and immunofluorescence analysis
    Mogens Fenger
    Department of Clinical Biochemistry, University Hospital of Copenhagen, Hvidovre, Denmark
    Clin Chem 50:2141-7. 2004
    b>Antinuclear antibodies (ANAs) are associated with several inflammatory rheumatic diseases...
  9. pmc Genetic dissection of lupus pathogenesis: a recipe for nephrophilic autoantibodies
    C Mohan
    Simmon s Arthritis Research Center, Center for Immunology, University of Texas Southwestern Medical School, Dallas 75235 8884, USA
    J Clin Invest 103:1685-95. 1999
    ..Whereas loci such as Sle1 may serve to breach tolerance to chromatin, full-blown pathogenic maturation of the autoantibody response appears to require additional input from other loci (such as Sle3) and gender-based factors...
  10. pmc Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells
    B A Cocca
    Department of Microbiology and Immunology, MCP Hahnemann University, Philadelphia, PA 19129, USA
    Proc Natl Acad Sci U S A 98:13826-31. 2001
    ..The results suggest that, in autoimmunity, B cells with Ig receptors for apoptotic cells and DNA are positively selected, and that the antibodies they produce have the potential to affect the clearance and processing of apoptotic cells...
  11. pmc Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis
    P Alba
    Lupus Research Unit, The Rayne Institute, UK
    Ann Rheum Dis 62:556-60. 2003
    ..Lupus nephritis (LN) is a common manifestation in patients with systemic lupus erythematosus (SLE). Autoantibodies and ethnicity have been associated with LN, but the results are controversial...
  12. ncbi Predominant autoantibody production by early human B cell precursors
    Hedda Wardemann
    Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA
    Science 301:1374-7. 2003
    ..Most of these autoantibodies were removed from the population at two discrete checkpoints during B cell development. Inefficient checkpoint regulation would lead to substantial increases in circulating autoantibodies...
  13. ncbi NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci
    S T Waters
    Division of Rheumatology and Immunology, The University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, Charlottesville, Virginia 22908, USA
    Clin Immunol 100:372-83. 2001
    ..These results provide evidence for the importance of background genes on the expression of SLE, with implications for genetic studies of human SLE...
  14. ncbi A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
    Dimitrios T Boumpas
    National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA
    Arthritis Rheum 48:719-27. 2003
    ..The primary outcome measure was 50% reduction in proteinuria without worsening of renal function...
  15. ncbi Impaired Fas response and autoimmunity in Pten+/- mice
    A Di Cristofano
    Department of Human Genetics Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Science 285:2122-5. 1999
    ..These results indicate that Pten is an essential mediator of the Fas response and a repressor of autoimmunity and thus implicate the PI 3-kinase/Akt pathway in Fas-mediated apoptosis...
  16. ncbi Editors and editing of anti-DNA receptors
    H Li
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Immunity 15:947-57. 2001
    ..Among the edited B cells is a subset of multispecific cells that express multiple receptors. One consequence of multispecificity is partial autoreactivity; these multispecific B cells may contribute to autoimmunity...
  17. pmc Prevalence and clinical significance of isotype specific antinuclear antibodies in primary biliary cirrhosis
    E I Rigopoulou
    Institute of Liver Studies, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Gut 54:528-32. 2005
    b>Antinuclear antibodies (ANA) giving a rim-like/membranous (RL/M) or a multiple nuclear dot (MND) pattern are highly specific for primary biliary cirrhosis (PBC). Aim and
  18. ncbi Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis
    Minoru Nakamura
    Clinical Research Center, National Hospital Organization NHO Nagasaki Medical Center and Department of Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Omura, Nagasaki, Japan
    Hepatology 45:118-27. 2007
    The predictive role of antinuclear antibodies (ANAs) remains elusive in the long-term outcome of primary biliary cirrhosis (PBC)...
  19. ncbi Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies
    Carol Feghali-Bostwick
    Division of Pulmonary, Allergy, and Critical Care Medicine and Simmons Center for Interstitial Lung Disease, University of Pittsburgh, 628 NW Montefiore, Pittsburgh, PA 15261, USA
    Arthritis Rheum 48:1956-63. 2003
    ..To examine concordance for systemic sclerosis (SSc) in monozygotic (MZ) and dizygotic (DZ) twins...
  20. ncbi B cell depletion therapy in systemic lupus erythematosus: relationships among serum B lymphocyte stimulator levels, autoantibody profile and clinical response
    G Cambridge
    Centre for Rheumatology Research, Department of Medicine, 46 Cleveland St, London W1T 4JF, UK
    Ann Rheum Dis 67:1011-6. 2008
    ..To assess the relationships between serum B lymphocyte stimulator (BLyS) levels, autoantibody profile and clinical response in patients with systemic lupus erythematosus (SLE) following rituximab-based B cell depletion therapy (BCDT)...
  21. ncbi Anti-Sm and anti-RNP antibodies
    P Migliorini
    Clinical Immunology Unit, Department of Internal Medicine, University of Pisa, Italy
    Autoimmunity 38:47-54. 2005
    ....
  22. ncbi Polygenic control of susceptibility to murine systemic lupus erythematosus
    L Morel
    Center for Mammalian Genetics, College of Medicine, University of Florida, Gainesville 32610
    Immunity 1:219-29. 1994
    ..Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system...
  23. pmc Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis
    Samuel T Waters
    The University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Exp Med 199:255-64. 2004
    ..These results reaffirm that anti-dsDNA and related Ab production and chronic glomerulonephritis are under independent genetic control. These findings have significant implications in the pathogenesis of systemic lupus erythematosus...
  24. ncbi Simultaneous identification of various antinuclear antibodies using an automated multiparameter line immunoassay system
    F J Lopez-Longo
    Service of Rheumatology, Hospital General Universitario Gregorio Maranon, Universidad Complutense of Madrid, Madrid, Spain
    Lupus 12:623-9. 2003
    ..Its most notable advantages are automated simultaneous detection of several autoantibodies in the same serum and its lower cost compared with ELISA techniques...
  25. ncbi Diagnostic accuracy of ELISA methods as an alternative screening test to indirect immunofluorescence for the detection of antinuclear antibodies. Evaluation of five commercial kits
    Elio Tonuttia
    Laboratorio Analisi Cliniche, Ospedale S Maria della Misericordia, Udine, Italy
    Autoimmunity 37:171-6. 2004
    Detection of antinuclear antibodies (ANA) is a fundamental laboratory test for diagnosing systemic autoimmune diseases. Currently, the method of choice is indirect immunofluorescence (IIF) on a HEp-2 cell substrate...
  26. ncbi Evaluation of two automated enzyme immunoassays for detection of antinuclear antibodies
    X Bossuyt
    Department of Laboratory Medicine, University Hospital Leuven, Belgium
    Clin Chem Lab Med 38:1033-7. 2000
    We evaluated two enzyme immunoassays (EIA) for detection of antinuclear antibodies (ANA) which became recently available and which were designed for application on a fully automated system; (i) the EIA-ANA screen kit from Sigma ..
  27. ncbi [Antinuclear antibodies in patients with chronic fatigue syndrome]
    Masahiko Nishikai
    National Hospital Organization Tokyo Medical Center
    Nihon Rinsho 65:1067-70. 2007
    Significance of antinuclear antibodies (ANA) in the patients with chronic fatigue syndrome (CFS) was reviewed...
  28. ncbi Evolution of antinuclear antibodies and clinical patterns in patients with active rheumatoid arthritis with longterm infliximab therapy
    Elisabeth Comby
    Laboratoire d Immunologie et Immunopathologie, UPRES EA 2128, and Service de Rhumatologie, CHU, Caen, France
    J Rheumatol 33:24-30. 2006
    ....
  29. pmc Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lymphoproliferative autoimmunity
    Xiaoyan Shi
    Simmon s Arthritis Research Center and the Center for Immunology, University of Texas Southwestern Medical School, Dallas 75235, USA
    J Exp Med 196:281-92. 2002
    ..Whereas FAS(lpr) functions as a recessive gene, Sle1 exhibits a gene dosage effect. These studies indicate that Sle1 and FAS(lpr) must be impacting alternate pathways leading to lymphoproliferative autoimmunity...
  30. pmc Specific antinuclear antibodies are associated with clinical features in systemic lupus erythematosus
    I E A Hoffman
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Ann Rheum Dis 63:1155-8. 2004
    To study associations between antinuclear antibodies (ANA) and signs/symptoms in patients with systemic lupus erythematosus (SLE).
  31. ncbi Evaluation of the BioPlex 2200 ANA screen for the detection of antinuclear antibodies and comparison with conventional methods
    Sophie Desplat-Jego
    Laboratoire d Immunologie, Hopital de la Conception, Marseille, France
    Ann N Y Acad Sci 1109:245-55. 2007
    BioPlex 2200 multiplexed assays system is an automatic method allowing detection of antinuclear antibodies (ANA)...
  32. ncbi Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
    M Botto
    Rheumatology Section, Hammersmith Campus, Imperial College School of Medicine, London, UK
    Nat Genet 19:56-9. 1998
    ..The phenotype associated with C1q deficiency was modified by background genes. These findings are compatible with the hypothesis that C1q deficiency causes autoimmunity by impairment of the clearance of apoptotic cells...
  33. ncbi Cutting edge: C1q protects against the development of glomerulonephritis independently of C3 activation
    D A Mitchell
    Rheumatology Section and Department of Histopathology, Hammersmith Campus, Imperial College School of Medicine, London, United Kingdom
    J Immunol 162:5676-9. 1999
    ....
  34. ncbi Signs of first-degree heart block occur in one-third of fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies
    Sven Erik Sonesson
    Karolinska Institutet, Stockholm, Sweden
    Arthritis Rheum 50:1253-61. 2004
    ..To prospectively investigate the development of fetal heart block in anti-SSA/Ro 52-kd-positive women, and to evaluate the usefulness of serial Doppler echocardiography in detecting early signs of congenital heart block...
  35. ncbi Primary biliary cirrhosis specific antinuclear antibodies in patients from Spain
    Dimitrios Petrou Bogdanos
    Am J Gastroenterol 99:763-4; author reply 765. 2004
  36. ncbi Do antinuclear antibodies in primary biliary cirrhosis patients identify increased risk for liver failure?
    Wei Hong Yang
    Center for Immunology and Inflammatory Diseasese, Massachusetts General Hospital, Boston, MA 02129, USA
    Clin Gastroenterol Hepatol 2:1116-22. 2004
    ..The objective of this study was to identify antinuclear antibody (ANA) markers that may be used to predict PBC outcome...
  37. ncbi Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study
    Kiyomitsu Miyachi
    First Diagnostic Division, Health Sciences Research Institute Inc, 106 Godo cho Hodogaya ku, Yokohama shi, Kanagawa 240 0005, Japan
    J Autoimmun 20:247-54. 2003
    ..This difference was found to be statistically significant. The presence of anti-p62 complex antibody may be related with the progressive or advanced state of PBC...
  38. ncbi Anti-DNA antibody subpopulations and lupus nephritis
    O P Rekvig
    Department of Biochemistry, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, Tromsø N 9037, Norway
    Autoimmun Rev 3:1-6. 2004
    ....
  39. ncbi Antigenic triggers and molecular targets for anti-double-stranded DNA antibodies
    B Deocharan
    The Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Lupus 11:865-71. 2002
    ..We conclude that a pathogenic, lupus-like autoantibody response can be induced by a peptide antigen, and that alpha-actinin is a cross-reactive renal target for the pathogenic anti-dsDNA autoantibody response in lupus mice...
  40. pmc The use of laboratory tests in the diagnosis of SLE
    W Egner
    Department of Immunology and Protein Reference Unit, Northern General Hospital, Sheffield, UK
    J Clin Pathol 53:424-32. 2000
    ....
  41. pmc Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains
    B S Andrews
    J Exp Med 148:1198-215. 1978
    ....
  42. ncbi Prevalence of disease-specific antinuclear antibodies in general population: estimates from annual physical examinations of residents of a small town over a 5-year period
    Nobuhide Hayashi
    Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan
    Mod Rheumatol 18:153-60. 2008
    The aim of this study was to investigate the types and prevalence of disease-specific antinuclear antibodies (ANAs) and their relationship to rheumatic diseases in the general Japanese population...
  43. ncbi Phagocytosis and clearance of apoptotic cells is mediated by MER
    R S Scott
    UNC Neuroscience Center, USA
    Nature 411:207-11. 2001
    ..Thus, the Mer receptor tyrosine kinase seems to be critical for the engulfment and efficient clearance of apoptotic cells. This has implications for inflammation and autoimmune diseases such as systemic lupus erythematosus...
  44. ncbi Decreased phagocytosis of apoptotic cells in diseased SLE mice
    R Licht
    Division of Nephrology 545, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    J Autoimmun 22:139-45. 2004
    ..In conclusion, during disease progression in murine SLE, apoptotic cell clearance becomes impaired, which might amplify further disease progression...
  45. ncbi Evidence-based guidelines for the use of immunologic tests: antinuclear antibody testing
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 47:434-44. 2002
  46. ncbi Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women
    A Brucato
    Niguarda Hospital, Milan, Italy
    Arthritis Rheum 44:1832-5. 2001
    ..Additional electrocardiographic abnormalities such as sinus bradycardia and prolongation of the QT interval may be present in their children...
  47. ncbi Anti-DNA and autoantibodies
    D S Pisetsky
    Division Rheumatology, Allergy and Clinical Immunology, Durham VA and Duke University Medical Centers, North Carolina 27705, USA
    Curr Opin Rheumatol 12:364-8. 2000
    Systemic lupus erythematosus is a prototypic autoimmune disease characterized by antinuclear antibodies (ANAs), including pathogenic specificities to DNA...
  48. ncbi Treatment with a consensus peptide based on amino acid sequences in autoantibodies prevents T cell activation by autoantigens and delays disease onset in murine lupus
    B H Hahn
    University of California, Los Angeles, USA
    Arthritis Rheum 44:432-41. 2001
    ..A striking effect is the ability of the peptide to tolerize T cell help for anti-DNA that is induced by multiple, structurally unrelated self antigens...
  49. ncbi Cutting edge: expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus
    C M Grimaldi
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 167:1886-90. 2001
    ..Thus, a sustained increase in E2 alters B cell development, leading to the survival, expansion, and activation of a population of autoreactive marginal zone B cells implicating this B cell subset in autoimmunity...
  50. pmc Autoantibody formation in patients with rheumatoid arthritis treated with anti-TNF alpha
    C Eriksson
    Department of Rheumatology, University Hospital, S 901 85 Umea, Sweden
    Ann Rheum Dis 64:403-7. 2005
    ..Research on autoantibody formation in patients treated with TNF alpha inhibitors has produced contradictory results...
  51. pmc Lupus nephritis: the central role of nucleosomes revealed
    Elin S Mortensen
    Department of Pathology, University of Tromsø, N 9037 Tromsø, Norway
    Am J Pathol 172:275-83. 2008
    ..The mechanisms leading to production of potentially nephritogenic anti-nucleosome antibodies and to overt lupus nephritis are interpreted in the context of these paradigms...
  52. pmc Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies
    Michael Mahler
    Dr Fooke Laboratorien GmbH, Neuss, Germany
    Arthritis Res Ther 7:R19-29. 2005
    ..Thus, anti-SMP detection using ELISA represents a new serological marker with which to diagnose and discriminate between systemic autoimmune disorders...
  53. ncbi Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus
    Annett M Jacobi
    University Hospital Charite, Berlin, Germany
    Arthritis Rheum 48:1332-42. 2003
    ..In order to determine whether SLE disease activity correlates with abnormal B lymphocyte activity, B cell subsets were analyzed, and their relationship to clinical and humoral measures of disease activity was assessed...
  54. ncbi Anti-double-stranded DNA antibodies, nucleosomes, and systemic lupus erythematosus: a time for new paradigms?
    O P Rekvig
    Department of Biochemistry, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Arthritis Rheum 48:300-12. 2003
  55. ncbi Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis
    J H Berden
    Division of Nephrology, University Hospital St Radboud, Nijmegen, The Netherlands
    Curr Opin Nephrol Hypertens 8:299-306. 1999
    ..Appreciation of this binding mechanism may lead to new treatment strategies, as shown for non-coagulant heparinoids...
  56. ncbi Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes
    C F Rubio
    Division of Basic Science, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA
    J Immunol 157:65-71. 1996
    ..These findings suggest similarities between the MRL/lpr T and B cell systems, because both fail to manifest clear central tolerance defects, but they nevertheless promote hyperplasia and autoimmunity in the peripheral immune system...
  57. ncbi Functional basis of sinus bradycardia in congenital heart block
    Keli Hu
    Molecular and Cellular Cardiology Program, VA New York Harbor Healthcare System, SUNY Downstate Medical Center and NYU School of Medicine, Brooklyn, NY 11209, USA
    Circ Res 94:e32-8. 2004
    ..The full text of this article is available online at http://circres.ahajournals.org..
  58. ncbi [Comparison of indirect immunofluorescence assay and ELISA for detecting antinuclear antibodies and anti-double-stranded DNA antibodies]
    Xue Qin
    Department of Clinical Laboratory, First Affiliated Hospital, Guangxi Medical University, Nanning, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:472-5. 2009
    To compare indirect immunofluorescence assay (IIFA) and enzyme-linked immunosorbent assay (ELISA) for detecting antinuclear antibodies (ANA) and anti-double-stranded DNA antibodies (anti-dsDNA).
  59. ncbi Immunochemical, structural and translocating properties of anti-DNA antibodies from (NZBxNZW)F1 mice
    T Ternynck
    Unités d Immunocytochimie, Departement d Immunologie, Institut Pasteur, Paris, 75015, France
    J Autoimmun 11:511-21. 1998
    ..Although all CDR2-3 reacted with dsDNA and other self antigens, each one exhibited a distinct polyreactivity profile...
  60. ncbi Autoantibodies to lens epithelium-derived growth factor/transcription co-activator P75 (LEDGF/P75) in children with chronic nonspecific complaints and with positive antinuclear antibodies
    Natsuko Kuwabara
    Department of Pediatrics, Nippon Medical School, Bunkyo City, Tokyo, Japan
    Autoimmunity 42:492-6. 2009
    ..Autoimmune fatigue syndrome (AIFS) is characterized by chronic nonspecific complaints, consistently positive antinuclear antibodies (ANA), and lack of alternate medical explanations...
  61. ncbi Light chain contribution to specificity in anti-DNA antibodies
    S M Ibrahim
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    J Immunol 155:3223-33. 1995
    ..Our results indicate that L chains in anti-DNA Ab are able to modulate DNA binding and contribute contact sites for additional determinants on a complex autoantigen...
  62. ncbi Antinuclear antibody screening in this new millennium: farewell to the microscope?
    H Nossent
    Department of Rheumatology, University Hospital Tromsø, Norway
    Scand J Rheumatol 30:123-6; discussion 127-8. 2001
    ..Thus, we suggest that the unspecific F-ANA test should no longer be considered the gold standard for the detection of clinically relevant autoantibodies...
  63. ncbi Detection of antinuclear antibodies by the Inno-Lia ANA update test in canine systemic rheumatic disease
    Helene Hansson-Hamlin
    the Department of Clinical Sciences, Swedish University of Agricultural Sciences, S 750 07 Uppsala, Sweden
    Vet Clin Pathol 39:215-20. 2010
    Certain systemic autoimmune diseases in dogs are characterized by high titers of circulating antinuclear antibodies (ANA), which can be demonstrated by indirect immunofluorescence (IIF)...
  64. ncbi [Evaluation of simultaneous detection of specific antinuclear antibodies using multiplexed technology]
    Kenichi Uto
    Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Rinsho Byori 57:941-53. 2009
    ..is a fully automated analyzer using multiplexed technology and BioPlex2200 ANA Screen can analyze 11 antinuclear antibodies (ANA). We evaluated simultaneous detection of 11 ANA and clinical utility as ANA screening test...
  65. ncbi Soluble P selectin in systemic sclerosis: relationship with von Willebrand factor, autoantibodies and diffuse or localised/limited disease
    A D Blann
    Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    Thromb Res 109:203-6. 2003
  66. ncbi Antinuclear antibodies recognize cellular autoantigens driven by apoptosis
    Roxana Ramírez-Sandoval
    Department of Molecular Biology, Centro de Biología Experimental, Universidad Autonoma de Zacatecas, Chepinque 306, Col Lomas de la Soledad, 98040, Zacatecas, Mexico
    Joint Bone Spine 70:187-94. 2003
    ..Present study addresses the issue whether cellular antigens recognised by antinuclear autoantibodies are driven by apoptosis...
  67. ncbi Effective B cell depletion with rituximab in the treatment of autoimmune diseases
    Christian Kneitz
    Medizinische Poliklinik der Universität Würzburg, Germany
    Immunobiology 206:519-27. 2002
    ..Further studies are needed to assess the clinical benefit of B cell depletion in the treatment of autoimmune diseases...
  68. ncbi Prevalence of antinuclear antibodies in 3 groups of healthy individuals: blood donors, hospital personnel, and relatives of patients with autoimmune diseases
    Guadalupe G Marin
    Division de Posgrado, Facultad de Ciencias Médicas y Biológicas Dr Ignacio Chávez, UMSNH, Morelia, Michoacan, Mexico
    J Clin Rheumatol 15:325-9. 2009
    b>Antinuclear antibodies (ANA) are frequently found in healthy populations...
  69. ncbi Primary biliary cirrhosis with additional features of autoimmune hepatitis: response to therapy with ursodeoxycholic acid
    Supriya Joshi
    Department of Medicine, The University Health Network, University of Toronto, Toronto, Ontario, Canada
    Hepatology 35:409-13. 2002
    ..The survival of patients testing positive or negative for antinuclear antibodies (ANA) was also examined...
  70. ncbi Mechanism of action of combined short-term CTLA4Ig and anti-CD40 ligand in murine systemic lupus erythematosus
    Xiaobo Wang
    Departments of Medicine and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461
    J Immunol 168:2046-53. 2002
    ..These results suggest that the effect of costimulatory blockade in remission induction must be mediated by a different mechanism than is demonstrated in the disease prevention studies...
  71. pmc Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
    Terry K Means
    Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 115:407-17. 2005
    ....
  72. pmc The mechanism by which a peptide based on complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab ameliorates experimental systemic lupus erythematosus
    E Eilat
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 98:1148-53. 2001
    ....
  73. ncbi Antinuclear antibodies and endometriosis
    J A Dias
    Department of Obstetrics and Gynecology, Medical School, University of Sao Paulo, Sao Paulo, Brazil
    Int J Gynaecol Obstet 93:262-3. 2006
  74. ncbi Anticardiolipin and antinuclear antibodies in cancer patients--a case control study
    J B Armas
    Hospital de Santo Espirito de Angra do Heroismo, Azores, Portugal
    Clin Exp Rheumatol 18:227-32. 2000
    ..To investigate patients with cancer for the frequency of IgG and IgM aCL and ANA in comparison to a group of age- and sex-matched controls...
  75. ncbi Screening of antinuclear antibodies: comparison between enzyme immunoassay based on nuclear homogenates, purified or recombinant antigens and immunofluorescence assay
    Sergio Bernardini
    Department of Internal Medicine and Department of Laboratory Medicine PTV, University of Rome Tor Vergata, Rome, Italy
    Clin Chem Lab Med 42:1155-60. 2004
    ....
  76. ncbi The rearranged V(H) domain of a physiologically selected anti-single-stranded DNA antibody as a precursor for formation of IgM and IgG antibodies to diverse antigens
    J Li
    Department of Biochemistry and Division of Immunology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Immunol 167:3746-55. 2001
    ..Consistent with the hypothesis, cells with a rearranged autoreactive V(H) domain selected for reactivity with a form of ssDNA did serve as precursors for cells producing IgM and IgG Abs to diverse Ags...
  77. ncbi Influence of clinical features, serum antinuclear antibodies, and lung function on survival of patients with systemic sclerosis
    S Jacobsen
    Department of Rheumatology, Hvidovre Hospital, Denmark
    J Rheumatol 28:2454-9. 2001
    ..To evaluate the independent contribution of several clinical and laboratory variables to the mortality of a cohort of Danish patients with systemic sclerosis (SSc)...
  78. ncbi Autoantibodies and self-reported health complaints in relatives of systemic lupus erythematosus patients: a community based approach
    H Laustrup
    Department of Internal Medicine, Section of Rheumatology, Odense University Hospital, Odense, Denmark
    Lupus 13:792-9. 2004
    ..The low ANA frequency among spouses of SLE patients argues against a significant autoantibody triggering effect of shared environment in adult life...
  79. ncbi Detection of perinuclear antineutrophil cytoplasmic antibodies and antinuclear antibodies in the diagnosis of canine inflammatory bowel disease
    Carolina Mancho
    Department of Animal Medicine and Surgery, College of Veterinary Medicine, Complutense University of Madrid, Av Puerta de Hierro s n, 28040 Madrid, Spain
    J Vet Diagn Invest 22:553-8. 2010
    ..Because of their similar pattern of fluorescence, antinuclear antibodies (ANA) could cause misleading interpretations...
  80. ncbi Antinuclear antibodies (ANA) in chronic hepatitis C virus infection: correlates of positivity and clinical relevance
    L J Yee
    London School of Hygiene and Tropical Medicine, London, UK
    J Viral Hepat 11:459-64. 2004
    ..Our observation of increased plasma cells in ANA+ biopsies might suggest B-cell polyclonal activity with a secondary clinical manifestation of increased serum immunoglobulins...
  81. ncbi Frequency of antinuclear antibodies in healthy children and adolescents
    Maria Odete Esteves Hilário
    Pediatric Rheumatology Unit, Department of Pediatrics, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Clin Pediatr (Phila) 43:637-42. 2004
    ..ANA was present in 42/116 patients (36.2%). In daily medical practice ANA determination should be required only in individuals with clinical signs and symptoms suggestive of autoimmune disease...
  82. ncbi Clinical implications of autoantibody screening in patients with autoimmune myositis
    A Ghirardello
    University of Padova, Division of Rheumatology, Department of Clinical and Experimental Medicine, Italy
    Autoimmunity 39:217-21. 2006
    ..To evaluate the clinical usefulness of serum autoantibody profiling in patients with autoimmune myositis...
  83. ncbi Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing
    C Chen
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Immunity 3:747-55. 1995
    ..The sd-tg model thus provides direct evidence for secondary rearrangement at VH-D-JH. This process may play a role in tolerance by editing autoreactive receptors and may also serve to diversify the VH repertoire...
  84. ncbi Prevalence of positive antinuclear antibodies in healthy children
    Siriwan Wananukul
    Division of Pediatric Dermatology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand
    Asian Pac J Allergy Immunol 23:153-7. 2005
    b>Antinuclear antibodies (ANA) frequently arise in the sera of children with connective tissue disease and is used in the diagnosis of these diseases. Therefore it is also important to know the prevalence of ANA in normal children...
  85. ncbi Detection of antinuclear antibodies by use of an enzyme immunoassay with nuclear HEp-2 cell extract and recombinant antigens: comparison with immunofluorescence assay in 307 patients
    N Hayashi
    Department of Clinical and Laboratory Medicine, Kobe University School of Medicine, 7-5-1 Kusunoki-cyo, Chuo-ku, Kobe, Hyogo 650-0017, Japan
    Clin Chem 47:1649-59. 2001
    BACKGROUND: A new enzyme immunoassay (EIA) for automated detection of antinuclear antibodies (ANAs) uses a mixture of HEp-2 cell extracts and multiple recombinant nuclear antigens immobilized on beads...
  86. pmc Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern
    Yijin Li
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Exp Med 196:1543-52. 2002
    ..Our results suggest that improper editing and failure to sequester autoreactive B cells may contribute to the breakdown of tolerance in MRL/lpr mice...
  87. ncbi Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry
    Micah T McClain
    Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, Oklahoma 73104, USA
    Nat Med 11:85-9. 2005
    ....
  88. pmc The clinical relevance of serum antinuclear antibodies in Japanese patients with systemic sclerosis
    Y Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Br J Dermatol 158:487-95. 2008
    ..Although SSc is a heterogeneous disease, it has been reported that the particular antinuclear antibodies (ANA) are often indicative of clinical features, disease course and overall severity.
  89. ncbi Outcome of pregnancies in patients with anti-SSA/Ro antibodies: a study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control group
    Nathalie Costedoat-Chalumeau
    Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Arthritis Rheum 50:3187-94. 2004
    ..To assess the pathologic nature of these manifestations, this study focused on electrocardiographic (EKG) variations in these children, comparing them with findings in a control group...
  90. ncbi Autoimmunity and atherosclerosis: the presence of antinuclear antibodies is associated with decreased carotid elasticity in young women. The Cardiovascular Risk in Young Finns Study
    Marja Pertovaara
    Department of Internal Medicine, Section of Rheumatology, Tampere UniversityHospital, Tampere, Finland
    Rheumatology (Oxford) 48:1553-6. 2009
    ..Our aim was to investigate whether positive ANAs in young adults are associated with risk factors for atherosclerosis or subclinical markers of atherosclerosis...
  91. ncbi Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis
    Paolo Muratori
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Alma Mater Studiorum, Universita di Bologna, Policlinico S Orsola Malpighi, Italy
    Am J Gastroenterol 98:431-7. 2003
    The clinical impact of antinuclear antibodies in primary biliary cirrhosis is uncertain...
  92. ncbi Drug-induced systemic lupus erythematosus and TNF-alpha blockers
    Aparna K Mohan
    Lancet 360:646. 2002
  93. ncbi Incidence of circulating antinuclear antibodies in cancer patients
    A Imran
    Department of Surgery, J N Medical College, A M U Aligarh 202 002, India
    Indian J Med Sci 57:113-6. 2003
    ..The results of this study confirm the earlier observation of necrosis of tumour tissue could be an important contributing factor for production of autoantibodies...
  94. ncbi B cell selection and allelic exclusion of an anti-DNA Ig transgene in MRL-lpr/lpr mice
    J H Roark
    Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 154:4444-55. 1995
    ....
  95. pmc Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice
    D M Tillman
    Department of Microbiology and Immunology, University of Tennessee, Memphis 38163
    J Exp Med 176:761-79. 1992
    ..native DNA; and (d) the results provide a structural explanation for the selective development of IgG antibody to native DNA as autoimmunity to DNA progresses in (NZB x NZW)F1 mice...
  96. ncbi Anti-DNA antibodies: aspects of structure and pathogenicity
    Y J Jang
    Laboratory of Immunology, Institute for Medical Science, Ajou University School of Medicine, Suwon 442 721, Korea
    Cell Mol Life Sci 60:309-20. 2003
    ..Structural information of lupus antibody interactions with both DNA and cross-reacting molecules will support use of ligands to inhibit tissue deposition of the antibodies and prevent lesion formation in lupus...
  97. pmc Antinuclear antibodies define a subgroup of paraneoplastic neuropathies: clinical and immunological data
    M Tschernatsch
    Department of Neurology, Justus Liebig University, Am Steg 14, 35385 Giessen, Germany
    J Neurol Neurosurg Psychiatry 76:1702-6. 2005
    ..Paraneoplastic neuropathy is a clinical and immunological heterogeneous disorder and attempts have been made to classify subgroups of this disease. Only 30-50% of the clinical defined cases have antineuronal antibodies...
  98. ncbi De novo production of IgG antinuclear antibodies in a neonate
    B G Kapogiannis
    Department of Pediatrics, University of Illinois College of Medicine, Chicago 60612, USA
    J Rheumatol 28:2744-7. 2001
    We describe the first case in which de novo production of multiple IgG antinuclear antibodies (ANA) occurred in a female neonate of an ANA negative mother...
  99. ncbi Antinuclear antibodies associate with loss of response to antitumour necrosis factor-alpha therapy in psoriasis: a retrospective, observational study
    A E Pink
    St John s Institute of Dermatology, Guy s and St Thomas NHS Foundation Trust and Division of Genetics and Molecular Medicine, King s College London, 9th Floor Guy s Tower, Great Maze Pond, London SE1 9RT, U K
    Br J Dermatol 162:780-5. 2010
    ..An increasing number of patients with severe psoriasis are failing to respond to antitumour necrosis factor (TNF)-alpha therapy (etanercept, infliximab and adalimumab)...
  100. ncbi Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies
    A A Bengtsson
    Department of Rheumatology, University Hospital, S 221 85 Lund, Sweden
    Lupus 9:664-71. 2000
    ..The close relationship between disease activity in SLE patients and IFN-alpha serum levels suggests that activation of the type 1 IFN system might be of importance in the disease process...
  101. ncbi Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain
    L Morel
    Department of Pathology, University of Florida, Gainesville, 32610, USA
    Mamm Genome 7:335-9. 1996
    ..They will also be instrumental to the positional cloning and identification of the genes responsible for SLE susceptibility, via the production of congenic recombinants...

Research Grants62

  1. Steroid Responsive Mechanisms in the Ear
    DENNIS ROYAL TRUNE; Fiscal Year: 2012
    ..microscopy;3) systemic autoimmune disease will be assessed by serum immune complexes, hematocrits, and antinuclear antibodies;4) cochlearspecificautoantibodies willbeassessedwithELISA,and5)steroid-mediatedcochleargeneproducts will ..
  2. The Role of Sex in Self Antigen Generation in SLE
    David Stephen Pisetsky; Fiscal Year: 2010
    ..As shown in studies of both patients and murine models, a signature feature of SLE is production of antinuclear antibodies (ANA)...
  3. MECHANISMS OF AUTOIMMUNITY IN SLE
    David Stephen Pisetsky; Fiscal Year: 2013
    ..Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANA) in association with multisystem inflammatory manifestations...
  4. Microparticles as a Source of Nuclear Antigens in Systemic Lupus Erythematosus
    David Stephen Pisetsky; Fiscal Year: 2010
    ..contain DNA and RNA in a form that is protected from extracellular nucleases and allows binding of antinuclear antibodies (ANAs)...
  5. Development &validationof a panel of antibodies for the diagnosis of sarcoidosis
    Lobelia Samavati; Fiscal Year: 2013
    ..abnormalities of the immune function and by the presence of antibodies, including rheumatoid factors and antinuclear antibodies found in this disorder...
  6. ANIMAL MODEL OF DRUG-INDUCED SLE
    David Aucoin; Fiscal Year: 1990
    ..characterized by lethergy, anoerexia, lymphadenopathy, severe hemolytic anemia, positive Coombs' test and antinuclear antibodies. The induction of this disease is dose-dependent and requires a free sulfur group on PTU...
  7. HUMAN HYBRIDOMAS IN THE ANALYSIS OF AUTOIMMUNE DISEASE
    BERNARD STOLLAR; Fiscal Year: 1990
    ..His laboratory will also test for auto-anti-idiotype antibodies in both hybridoma cultures and in sera, and determine whether their concentrations fluctuate in relation to disease activity...
  8. EPIDEMIOLOGY OF RAYNAUD PHENOMENON
    HILDEGARD MARICQ; Fiscal Year: 1992
    ..will be studied: capillary morphology, capillary blood flow, digital blood pressure, digital blood flow, antinuclear antibodies. The results of this study will provide information regarding regional variations in the prevalence of RP, ..
  9. NUCLEAR PROTEINS AND AUTOIMMUNITY
    SALLIE HOCH; Fiscal Year: 1992
    b>Antinuclear antibodies are a hallmark of autoimmune disease...
  10. AUTOMATED, QUANTITATIVE IMMUNOFLUORESCENT ASSAY
    KENNETH NEWTON; Fiscal Year: 2003
    ..Erythematosus, Sjorgren syndrome and scleroderma often makes use of an Immunofluorescent assay (IFA) for antinuclear antibodies (ANA). More detailed diagnostic support may also utilize an IFA test for double-stranded DNA (dsDNA)...
  11. AUTOIMMUNITY IN MURINE GRAFT-VERSUS-HOST DISEASE
    BRIAN KOTZIN; Fiscal Year: 1993
    ....
  12. AUTOANTIBODIES TO HISTONES AND CHROMATIN IN EPITOPES
    Marc Monestier; Fiscal Year: 2001
    ..panels of monoclonal antibodies obtained from these transgenic mice to understand structural features of antinuclear antibodies such as the respective roles of the heavy and light chains and of somatic mutations in binding to ..
  13. FACTORS AFFECTING CHEMICALLY INDUCED MURINE DIABETES
    Noel Maclaren; Fiscal Year: 1980
    ..SZ also induced some antinuclear antibodies. Alloxan given to 3 week old male CDl mice at 240 mg/kg produced acute islet cell necrosis and diabetes...
  14. Diagnostic Assays for Rheumatic Diseases
    John Harley; Fiscal Year: 2001
    ....
  15. T-CELL CONTROL OF AUTOREACTIVITY IN SLE
    Philip Cohen; Fiscal Year: 2002
    ..DESCRIPTION: (Adapted from the applicant's abstract) - T cells regulate the production of anti-Sm and other antinuclear antibodies in autoimmune mice...
  16. Compressed Autoantibody Induction Heralding Autoimmunity
    Andreas Reimold; Fiscal Year: 2006
    ..As one example, antinuclear antibodies appear 3...
  17. Endothelial reactivity and nitric oxide synthetase activity in the ALMS (Aspreva
    Robert Clancy; Fiscal Year: 2009
    ..Relevance to public health: The association of markers/indices of NOS2 expression with mechanism of action of a successful drug treatment in lupus nephritis would be a major advance. ..
  18. Cardiac myofibroblasts in autoimmune-associated CHB
    Robert Clancy; Fiscal Year: 2002
    ....
  19. Are IQs low in offspring of euthyroid women with low T4
    Wendy Craig; Fiscal Year: 2008
    ..It is intended that the study be continued for five more years (total of 10) in order to obtain additional estimates of neuropsychological development in the children at a time when more extensive testing can be performed. ..
  20. ROLE OF PPAR GAMMA IN LUPUS NEPHRITIS
    Gary Gilkeson; Fiscal Year: 2005
    ..As agonists of PPAR gamma (the thiazolidinediones) are already approved for human use, insight gained from these studies can be quickly translated into human trials. ..
  21. The vital role of BAFF in the development of SLE
    William Stohl; Fiscal Year: 2010
    ..abstract_text> ..
  22. Identifying Gene Interactions in SLE by Mixed Chimeras
    Eric Sobel; Fiscal Year: 2006
    ..unreadable] Successful completion of these experiments would identify a novel method of systematically identifying epistatic interactions in an important murine model of SLE. [unreadable] [unreadable]..
  23. BRAIN CELL DEATH IN MRL MICE: TARGETS AND MECHANISMS
    Boris Sakic; Fiscal Year: 2004
    ..abstract_text> ..
  24. ROLE OF COMPLEMENT FACTOR B IN THE PATHOGENESIS OF SLE
    Gary Gilkeson; Fiscal Year: 2004
    ..These studies will provide new insight into the role of the alternative pathway in disease and potentially provide a new therapeutic target (Factor B) in immune complex mediated diseases. ..
  25. Effect of autoantibodies on lung fibroblast phenotype
    JEAN PFAU; Fiscal Year: 2006
    ..exposure is associated with pulmonary fibrosis as well as autoimmune responses, including increased antinuclear antibodies. We have recently completed a pilot study of the asbestos-exposed population of Libby MT that suggests ..
  26. FUNCTIONAL LOCI MODIFYING SLE RENAL DISEASE
    Eric Sobel; Fiscal Year: 2003
    ..abstract_text> ..
  27. Genetics of Autontibody Diversification
    Umesh Deshmukh; Fiscal Year: 2008
    ..The proposal addresses a significant issue in autoimmunity and will serve well as a training vehicle to obtain the stated goals by the PI. ..
  28. Receptor Editing in Autoimmune and Normal Mice
    ANN FEENEY; Fiscal Year: 2009
    ..The information gained in these aims should give insights into the response of the various Ig loci to receptor editing signals, and how these processes may potentially be misregulated in B cells of autoimmune mice. ..
  29. Pathogen-specific T cell responses in patients with SLE
    Insoo Kang; Fiscal Year: 2008
    ..abstract_text> ..
  30. Fifth International Nanomedicine and Drug Delivery
    Vladimir Torchilin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  31. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2009
    ..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
  32. The Renal Pathogenicity of Anti-DNA Antibodies
    Chaim Putterman; Fiscal Year: 2008
    ..abstract_text> ..
  33. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2010
    ..These studies will provide insights into pathogenesis of lupus nephritis and identify checkpoints for intervention in patients. ..
  34. Role of Leptin in Systemic Lupus Erythematosus
    Antonio La Cava; Fiscal Year: 2010
    ..This study will detail the effects of leptin on human lupus and compare the potential of different leptin-based approaches with the goal to improve the current therapeutic management of human lupus. ..
  35. Cell Death and Antibody-Mediated Protection from Autoimmunity
    GREGG JOSHUA SILVERMAN; Fiscal Year: 2010
    ....
  36. MOLECULAR ANALYSIS OF THE ANTIH INFLUENZAE RESPONSE
    ANN FEENEY; Fiscal Year: 2001
    ..We will also further analyze the diversity in the ani-hib response through the use of combinatorial libraries, correlating affinity with the Vh, Vk and CDR3's which are used. ..
  37. Thymocyte tuning after selection: mechanisms to avoid autoreactivity
    Terri M Laufer; Fiscal Year: 2010
    ..These experiments will define the mechanisms which regulate a critical thymic pathway that the immune system utilizes to avoid autoreactivity. ..
  38. MECHANISMS OF AUTOREACTIVITY IN SLE
    Robert Eisenberg; Fiscal Year: 2009
    ..Such insights should be readily translatable to human autoimmune diseases. ..
  39. GENETIC PREDICTORS OF RESPONSE TO TREATMENT IN EARLY RA
    S Bridges; Fiscal Year: 2001
    ..abstract_text> ..
  40. B CELL SUPERANTIGENS AND IMMUNE REGULATION
    Gregg Silverman; Fiscal Year: 2008
    ..In addition, these studies will lead to a better understanding of the immunobiologic activities of a virulence factor from one of the most important causes of life-threatening infection in the US. ..
  41. AUTOANTIBODIES AS MARKERS OF BREAST CANCER
    FELIX FERNANDEZ MADRID; Fiscal Year: 2002
    ..Associations will be sought between serum reactivities, patient diagnosis and existing ten-year outcome data to assess the potential diagnostic and prognostic value of each antigen. ..
  42. DEXASOME BASED IMMUNOTHERAPY OF LUNG CANCER
    Michael Morse; Fiscal Year: 2002
    ..This clinical trial will form the background for further trials designed to demonstrate both immunology and clinical benefits of dexosome-based immunotherapy. ..
  43. ULTRA-HIGH AFFINITY ANTIBODIES TO DETECT SINGLE INFECTIO
    R Williamson; Fiscal Year: 2002
    ..abstract_text> ..
  44. FLOW CYTOMETER
    Tony Marion; Fiscal Year: 2003
    ..abstract_text> ..
  45. MOLECULAR BIOLOGY OF TRANSALDOLASE
    Andras Perl; Fiscal Year: 2004
    ..The proposed studies with the availability of unique reagents and existing model systems will further our knowledge on the role of TAL in the PPP, apoptosis signaling, and related disease processes. ..
  46. Pain Medication Use & Risk Factors for Opioid Dependence
    Daniel Solomon; Fiscal Year: 2004
    ..Our goal is to use the results of the proposed research to inform a future intervention to improve opioid prescribing within this large pharmacy benefits program. ..
  47. FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERS
    MARY CORR; Fiscal Year: 2004
    ..The results of these studies will both contribute to, and will utilize, the resources of the OA biomarker consortium. ..
  48. Role of arginine deficiency in pathogenesis of lupus
    Minoru Satoh; Fiscal Year: 2004
    ..abstract_text> ..
  49. Mitochondrial dysfunction in patients with SLE
    Andras Perl; Fiscal Year: 2004
    ..Thus, checkpoints of mitochondrial hyperpolarization could represent novel targets of pharmacological intervention in patients with SLE. ..
  50. T cell diversity in the induction of autoimmunity
    Terri Laufer; Fiscal Year: 2006
    ..Understanding the requirements for T cell diversity and the interactions between "graft" T cells and host antigen presenting cells offers improved immunologic targets for preventing GVHD following bone marrow transplant. ..
  51. Visual outcomes & quality of life in CMV retinitis
    Jennifer Thorne; Fiscal Year: 2006
    ..abstract_text> ..
  52. DC-CD4 interactions in Th2 differentiation
    Terri Laufer; Fiscal Year: 2006
    ..abstract_text> ..
  53. Spondyloarthritis 2006; The Unmet Needs
    John Reveille; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  54. Genetics of Severe Systemic Lupus Erythematosus (SLE) defined by thrombocytopenia
    R Scofield; Fiscal Year: 2007
    ..Finally, Specific Aim 4 will assemble a new cohort of families multiplex for SLE so that linkages and associations as well as particular polvmorphisms can be prospectively confirmed. ..
  55. 2007 International Peripheral Nerve Society Meeting at Snowbird, Utah
    A Smith; Fiscal Year: 2007
    ..The meeting directly impacts public health and patient care by disseminating important new ideas (both research and therapeutic) and by developing consensus guidelines. [unreadable] [unreadable] [unreadable]..
  56. SIGNAL TRANSDUCTION BY IGM IN B LYMPHOCYTES
    Michel Nussenzweig; Fiscal Year: 2002
    ..These studies have potential implications for understanding how B cells develop and produce immune responses in vivo. ..