Genomes and Genes
Summary: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
Publications372 found, 100 shown here
- Systemic lupus erythematosusAnisur Rahman
Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom
N Engl J Med 358:929-39. 2008
- Revised diagnostic criteria for neuromyelitis opticaD M Wingerchuk
Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
Neurology 66:1485-9. 2006..A serum autoantibody marker, NMO-IgG, is highly specific for NMO. The authors propose revised NMO diagnostic criteria that incorporate NMO-IgG status...
- A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosisVanda A Lennon
Department of Neurology, Mayo Clinic Rochester, Rochester, MN 55905, USA
Lancet 364:2106-12. 2004..We assessed the capacity of a putative marker for neuromyelitis optica (NMO-IgG) to distinguish neuromyelitis optica and related disorders from multiple sclerosis...
- The spectrum of neuromyelitis opticaDean M Wingerchuk
Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
Lancet Neurol 6:805-15. 2007..NMO-IgG reacts with the water channel aquaporin 4. Data suggest that autoantibodies to aquaporin 4 derived from peripheral B cells cause the activation of complement, inflammatory demyelination, ..
- IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channelVanda A Lennon
Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Exp Med 202:473-7. 2005..NMO may represent the first example of a novel class of autoimmune channelopathy...
- Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient miceRikinari Hanayama
Department of Genetics, Osaka University Medical School, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
Science 304:1147-50. 2004..These data demonstrate that MFG-E8 has a critical role in removing apoptotic B cells in the germinal centers and that its failure can lead to autoimmune diseases...
- Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III)Joseph G Hollowell
Centers for Disease Control, National Center for Environmental Health, Division of Emergency and Environmental Services, Atlanta, Georgia 30341, USA
J Clin Endocrinol Metab 87:489-99. 2002..A large proportion of the U.S. population unknowingly have laboratory evidence of thyroid disease, which supports the usefulness of screening for early detection...
- Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritisSolbritt Rantapaa-Dahlqvist
Umea Universitet, Umea, Sweden
Arthritis Rheum 48:2741-9. 2003....
- Projection of an immunological self shadow within the thymus by the aire proteinMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Science 298:1395-401. 2002..These findings highlight the importance of thymically imposed "central" tolerance in controlling autoimmunity...
- Development of autoantibodies before the clinical onset of systemic lupus erythematosusMelissa R Arbuckle
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
N Engl J Med 349:1526-33. 2003Although much is known about the natural history of systemic lupus erythematosus (SLE), the development of SLE autoantibodies before the diagnosis of the disease has not been extensively explored...
- Mast cells: a cellular link between autoantibodies and inflammatory arthritisDavid M Lee
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 297:1689-92. 2002Previous studies have revealed that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice...
- Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosisShanu F Roemer
Department of Neurology, Mayo Clinic, College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Brain 130:1194-205. 2007..These findings strongly support a role for a complement activating AQP4-specific autoantibody as the initiator of the NMO lesion, and further distinguish NMO from MS...
- Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis opticaJeffrey L Bennett
Department of Neurology and Ophthalmology, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
Ann Neurol 66:617-29. 2009The serum of most neuromyelitis optica (NMO) patients contains autoantibodies (NMO-IgGs) directed against the aquaporin-4 (AQP4) water channel located on astrocyte foot processes in the perivessel and subpial areas of the brain...
- Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivoMonika Bradl
Department of Neuroimmunology, Medical University Vienna, Center for Brain Research, Vienna, Austria
Ann Neurol 66:630-43. 2009..A diagnostic hallmark of this disease is the presence of serum autoantibodies against the water channel aquaporin-4 (AQP-4) on astrocytes.
- Predominant autoantibody production by early human B cell precursorsHedda Wardemann
Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA
Science 301:1374-7. 2003..Most of these autoantibodies were removed from the population at two discrete checkpoints during B cell development...
- The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetesJanet M Wenzlau
Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 104:17040-5. 2007..A high-ranking candidate, the zinc transporter ZnT8 (Slc30A8), was targeted by autoantibodies in 60-80% of new-onset T1D compared with <2% of controls and <3% type 2 diabetic and in up to 30% of ..
- M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathyLaurence H Beck
Boston University School of Medicine, Boston, MA, USA
N Engl J Med 361:11-21. 2009..Idiopathic membranous nephropathy, a common form of the nephrotic syndrome, is an antibody-mediated autoimmune glomerular disease. Serologic diagnosis has been elusive because the target antigen is unknown...
- IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosusTimothy B Niewold
Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, Illinois 60637, USA
Ann Rheum Dis 71:463-8. 2012..Genetic variation in IRF5 is associated with SLE susceptibility; however, it is unclear how IRF5 functional genetic elements contribute to human disease...
- Autoantibody signatures in prostate cancerXiaoju Wang
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
N Engl J Med 353:1224-35. 2005..New biomarkers, such as autoantibody signatures, may improve the early detection of prostate cancer...
- Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in miceSamira Saadoun
St George s, University of London, London SW17 0RE, UK
Brain 133:349-61. 2010Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system associated with autoantibodies against the glial water channel protein aquaporin-4...
- Autoantibodies associated with diseases of the CNS: new developments and future challengesAngela Vincent
Neuroimmunology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
Lancet Neurol 10:759-72. 2011....
- Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodiesBarton F Haynes
Duke University School of Medicine, Durham, NC 27710, USA
Science 308:1906-8. 2005..demonstrate that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin...
- Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentinUlrike Harre
Department of Internal Medicine 3, University of Erlangen Nuremberg, Erlangen, Germany
J Clin Invest 122:1791-802. 2012..In human rheumatoid arthritis (RA), the most severe inflammatory joint disease, autoantibodies against citrullinated proteins are among the strongest risk factors for bone destruction...
- Evolving concepts of rheumatoid arthritisGary S Firestein
Division of Rheumatology, Allergy and Immunology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0656, USA
Nature 423:356-61. 2003..Early theories on the pathogenesis of rheumatoid arthritis focused on autoantibodies and immune complexes...
- Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupusSean R Christensen
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Immunity 25:417-28. 2006..previously that Toll-like receptor (TLR) 9, recognizing DNA, is required for the spontaneous generation of DNA autoantibodies, but not for the development of lupus nephritis in susceptible mice...
- Autoantibodies targeting galactose-deficient IgA1 associate with progression of IgA nephropathyFrancois Berthoux
Nephrology, Dialysis, and Renal Transplantation Department, University North Hospital, 42055 Saint Etienne Cedex 2, France
J Am Soc Nephrol 23:1579-87. 2012..Circulating autoantibodies that recognize such galactose-deficient IgA1 as an autoantigen, or the levels of the autoantigen itself, may ..
- IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLECaroline Grönwall
Department of Medicine, NYU School of Medicine, New York, NY 10016, USA
Clin Immunol 142:390-8. 2012Emerging evidence suggests that there are IgM-autoantibodies that may play protective roles in SLE...
- Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodiesChih Long Liu
Department of Medicine, Division of Immunology and Rheumatology, Stanford School of Medicine, 269 Campus Drive, Stanford, California 94305, USA
Arthritis Res Ther 14:R25. 2012..We hypothesized that NETs and their unique histone PTMs might be capable of inducing autoantibodies that target histones.
- Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritisHeidi Kokkonen
Umea University Hospital, Umea, Sweden
Arthritis Rheum 62:383-91. 2010..To identify whether cytokines, cytokine-related factors, and chemokines are up-regulated prior to the development of rheumatoid arthritis (RA)...
- Follicular helper T cells are required for systemic autoimmunityMichelle A Linterman
Division of Immunology and Genetics, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia
J Exp Med 206:561-76. 2009Production of high-affinity pathogenic autoantibodies appears to be central to the pathogenesis of lupus...
- Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damageJing Shi
Department of Rheumatology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
Proc Natl Acad Sci U S A 108:17372-7. 2011..ACPA and anti-CarP antibodies are distinct autoantibodies because, in selected double-positive patients, the anti-CarP antibody binding to carbamylated antigens could ..
- Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosusCasandra C van Bavel
Department of Nephrology, Nephrology Research Laboratory, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Ann Rheum Dis 70:201-7. 2011..Released chromatin, modified during apoptosis, activates the immune system resulting in the formation of autoantibodies. A study was undertaken to identify apoptosis-induced histone modifications that play a role in SLE.
- Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodiesJosep Dalmau
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Lancet Neurol 7:1091-8. 2008..We aimed to analyse the clinical and immunological features of patients with the disorder and examine the effects of antibodies against NMDA receptors in neuronal cultures...
- Antibody to aquaporin-4 in the long-term course of neuromyelitis opticaS Jarius
Neurosciences Group, Weatherall Institute of Molecular Medicine, and Department of Neurology, John Radcliffe Hospital, University of Oxford, UK
Brain 131:3072-80. 2008..preceded by an up to 3-fold increase in AQP4-Ab titres, which was not paralleled by a rise in other serum autoantibodies in one patient...
- A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunityCarola G Vinuesa
Division of Immunology and Genetics, John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
Nature 435:452-8. 2005..sanroque mice fail to repress diabetes-causing T cells, and develop high titres of autoantibodies and a pattern of pathology consistent with lupus...
- Serum autoantibodies as biomarkers for early cancer detectionHwee Tong Tan
Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore
FEBS J 276:6880-904. 2009b>Autoantibodies against autologous tumor-associated antigens have been detected in the asymptomatic stage of cancer and can thus serve as biomarkers for early cancer diagnosis...
- Toward defining the autoimmune microbiome for type 1 diabetesAdriana Giongo
Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611 0700, USA
ISME J 5:82-91. 2011..In addition, bacteria that negatively correlated with the autoimmune state may prove to be useful in the prevention of autoimmunity development in high-risk children...
- p53 Antibodies in the sera of patients with various types of cancer: a reviewT Soussi
Laboratoire de Génotoxicologie des tumeurs, Institut Curie, Paris, France
Cancer Res 60:1777-88. 2000..The finding of p53-Abs in the sera of individuals who are at high risk of cancer, such as exposed workers or heavy smokers, indicates that they have promising potential in the early detection of cancer...
- Autoantibodies in breast cancer: their use as an aid to early diagnosisC Chapman
Division of Breast Surgery, The University of Nottingham, Nottingham, UK
Ann Oncol 18:868-73. 2007There is increasing evidence that the immune system produces a humoral response to cancer-derived antigens. This study assessed the diagnostic potential of autoantibodies to multiple known tumour-associated proteins.
- Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titreToshiyuki Takahashi
Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
Brain 130:1235-43. 2007....
- Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complicationsRoberto Negro
Department of Endocrinology, Azienda Ospedaliera LE 1, P O V Fazzi, Piazza F Muratore, 73100 Lecce, Italy
J Clin Endocrinol Metab 91:2587-91. 2006..Euthyroid women with autoimmune thyroid disease show impairment of thyroid function during gestation and seem to suffer from a higher rate of obstetrical complications...
- Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgMM Boes
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 97:1184-9. 2000..and rheumatoid arthritis are characterized by the presence of high levels of circulating IgM and IgG autoantibodies. Although IgG autoantibodies often are pathogenic, the role of IgM autoantibodies in autoimmune disease is not ..
- Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferationJonathan A Deane
Laboratory of Immunogenetics, NIAID NIH, Rockville, MD 20852, USA
Immunity 27:801-10. 2007..These results underscore the importance of tightly regulating expression of TLR7 to prevent spontaneous triggering of harmful autoreactive and inflammatory responses...
- Peripheral and central biodistribution of (111)In-labeled anti-beta-amyloid autoantibodies in a transgenic mouse model of Alzheimer's diseaseMichael Bacher
Department of Neurology, Philipps University, Rudolf Bultmann Str 8, 35033 Marburg, Germany
Neurosci Lett 449:240-5. 2009..the biodistribution of intravenously applicated (111)indium-conjugated affinity-purified human polyclonal autoantibodies (NAbs-Abeta) was compared to that of monoclonal anti-Abeta(1-17) (6E10), anti-Abeta(17-24) antibodies (4G8) ..
- Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritisJeremy Sokolove
Division of Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, United States of America
PLoS ONE 7:e35296. 2012..Though prior studies have demonstrated the appearance of RA-related autoantibodies years before the onset of clinical RA, the pattern of immunologic events preceding the development of RA ..
- Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic riskV Parikka
Department of Pediatrics, Turku University Hospital, Kiinamyllynkatu 4 8, PO Box 52, 20521 Turku, Finland
Diabetologia 55:1926-36. 2012The aim of the study was to investigate the timing of the appearance of autoantibodies associated with type 1 diabetes between birth and puberty, the natural fate of these autoantibodies and the predictive power of autoantibody ..
- Clinical validation of an autoantibody test for lung cancerP Boyle
International Prevention Research Institute, Lyon, France
Ann Oncol 22:383-9. 2011b>Autoantibodies may be present in a variety of underlying cancers several years before tumours can be detected and testing for their presence may allow earlier diagnosis...
- Complement activation by (auto-) antibodiesNina A Daha
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Mol Immunol 48:1656-65. 2011..In the current review, we discuss complement activation by (auto-) antibodies by the different pathways...
- Diagnosis of Parkinson's disease based on disease-specific autoantibody profiles in human seraMin Han
University of Medicine and Dentistry of New Jersey Graduate School of Biomedical Sciences at the School of Osteopathic Medicine, Stratford, New Jersey, United States of America
PLoS ONE 7:e32383. 2012..In the present study, we used human protein microarrays to reveal serum autoantibodies that are differentially expressed among PD and control subjects...
- Different stages of rheumatoid arthritis: features of the synovium in the preclinical phaseM G H van de Sande
Division of Clinical Immunology and Rheumatology, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
Ann Rheum Dis 70:772-7. 2011..It is currently unknown whether the disease process starts in the synovium, the primary target of RA, or at other sites in the body...
- Autoantibodies against tumor-related antigens: incidence and biologic significanceSebastian Kobold
Department of Oncology, Hematology, Stem Cell Transplantation with the section Pneumology, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Hum Immunol 71:643-51. 2010..little has been done to systematically evaluate the significance of spontaneously occurring tumor-associated autoantibodies. For this article, we screened the relevant literature on the incidence and significance of tumor-induced ..
- Autoantibodies to estrogen receptor α interfere with T lymphocyte homeostasis and are associated with disease activity in systemic lupus erythematosusTania Colasanti
Istituto Superiore di Sanita, Rome, Italy, and San Raffaele Institute Sulmona, L Aquila, Italy
Arthritis Rheum 64:778-87. 2012..Aberrations of lymphocyte homeostasis that lead to the production of multiple pathogenic autoantibodies, including autoantibodies specific to estrogen receptor (ER), have been detected in the peripheral blood of ..
- NMO-IgG predicts the outcome of recurrent optic neuritisM Matiello
Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
Neurology 70:2197-200. 2008..Recurrent ON may herald multiple sclerosis (MS) or NMO, or it may occur as an isolated syndrome. The prognosis and response to therapy differs in each of these contexts...
- Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin trapsNishant Dwivedi
University of Tennessee Health Science Center, Memphis, TN 38163, USA
Arthritis Rheum 64:982-92. 2012..To test the hypothesis that autoantigen modifications by peptidylarginine deiminase type 4 (PAD-4) increase immunoreactivity...
- A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritisLeonid Padyukov
Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Ann Rheum Dis 70:259-65. 2011..The aim of the current study is to provide and compare GWAS data for both subsets...
- Autoantibodies in lung cancer: possibilities for early detection and subsequent cureC J Chapman
Division of Breast Surgery, The University of Nottingham, Nottingham NG5 1PB, UK
Thorax 63:228-33. 2008..b>Autoantibodies have been shown to be present in the circulation of people with various forms of solid tumour before cancer-..
- Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and NutritionIvor D Hill
North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, Flourtown, PA 19031, USA
J Pediatr Gastroenterol Nutr 40:1-19. 2005..This document represents the official recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition on the diagnosis and treatment of celiac disease in children and adolescents...
- Toll-like receptors in systemic autoimmune diseaseAnn Marshak-Rothstein
Department of Microbiology, Boston University School of Medicine, 80 East Concord Street, Boston, Massachusetts 02118, USA
Nat Rev Immunol 6:823-35. 2006....
- Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. American College of PathologistsA Kavanaugh
University of Texas Southwest Medical School, Dallas, USA
Arch Pathol Lab Med 124:71-81. 2000..based on published medical literature for use of the antinuclear antibody (ANA) test and tests for specific autoantibodies to nuclear antigens in the diagnostic evaluation, prognostic assessment, and monitoring of patients with ..
- Circulating autoantibodies to phosphorylated α-enolase are a hallmark of pancreatic cancerBarbara Tomaino
Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, Turin, Italy
J Proteome Res 10:105-12. 2011..In PDAC patients, α-enolase (ENOA) is up-regulated and elicits the production of autoantibodies. Here, we analyzed the autoantibody response to post-translational modifications of ENOA in PDAC patients...
- The pathogenesis of idiopathic membranous nephropathy: a 50-year odysseyRichard J Glassock
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Am J Kidney Dis 56:157-67. 2010..Circulating autoantibodies (immunoglobulin G4 and immunoglobulin G1 subclasses) interacting with antigens native to or planted in the ..
- Epidermal transglutaminase (TGase 3) is the autoantigen of dermatitis herpetiformisMiklós Sárdy
Department of Dermato Venereology, Semmelweis University, H 1085 Budapest, Maria u 41, Hungary
J Exp Med 195:747-57. 2002....
- Apoptosis-associated acetylation on histone H2B is an epitope for lupus autoantibodiesCasandra C van Bavel
Nephrology Research Laboratory, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
Mol Immunol 47:511-6. 2009..Here, we evaluate whether apoptosis-induced histone modifications on H2B exist that are targeted by LG11-2 or lupus-derived plasmas...
- Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strainsL Morel
Departments of Medicine and Pathology, University of Florida, Gainesville, FL 32610, USA
Proc Natl Acad Sci U S A 97:6670-5. 2000....
- A survey of the humoral immune response of cancer patients to a panel of human tumor antigensE Stockert
Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York 10021, USA
J Exp Med 187:1349-54. 1998..As the proportion of melanomas expressing NY-ESO-1 is 20-40% and only patients with NY-ESO-1(+) tumors have antibody, this would suggest that a high percentage of patients with NY-ESO-1(+) tumors develop an antibody response to NY-ESO-1...
- Autoantibody signatures: progress and perspectives for early cancer detectionC Desmetz
CHU Montpellier, Laboratoire de Biologie Cellulaire et Hormonale, Hopital Arnaud de Villeneuve, Montpellier, France
J Cell Mol Med 15:2013-24. 2011..with cancer and no signs of overt metastases, sensitive methods have been developed to identify circulating autoantibodies and their antigen counterparts in several cancers...
- Autism: maternally derived antibodies specific for fetal brain proteinsDaniel Braunschweig
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, CA, USA
Neurotoxicology 29:226-31. 2008..A potential role for maternal autoantibodies in the etiology of some cases of autism has been proposed in previous studies...
- Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteinsS Horkko
Department of Medicine, University of California, San Diego, La Jolla, California 92093 0682
J Clin Invest 103:117-28. 1999We recently cloned monoclonal IgM autoantibodies which bind to epitopes of oxidized low-density lipoprotein (OxLDL) from apoE-deficient mice (EO- autoantibodies)...
- Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1Tihamer Orban
Joslin Diabetes Center, Boston, Massachusetts, USA
Diabetes Care 32:2269-74. 2009..prospective studies regarding the prediction of type 1 diabetes by specific types of pancreatic islet autoantibodies, either alone or in combination...
- Autoantibodies in lupus: culprits or passive bystanders?Ole P Rekvig
Molecular Pathology Research Group, Institute of Medical Biology, University of Tromsø, Norway
Autoimmun Rev 11:596-603. 2012Several autoantibodies are culprits in the pathogenesis of organ damage in systemic lupus erythematosus, by means of established or postulated mechanisms, whereby inducing a perturbation of cell structure and function, with consequent ..
- Large-scale analysis of tumor necrosis factor α levels in systemic lupus erythematosusCorinna E Weckerle
University of Chicago, Chicago, Illinois
Arthritis Rheum 64:2947-52. 2012..The aim of this study was to look for associations between serum TNFα levels, clinical manifestations of SLE, autoantibodies, and serum interferon-α (IFNα) levels in a large multiancestral SLE cohort.
- Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritisJie Ma
Department of Laboratory Medicine, The Affiliated People s Hospital, and School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China
Clin Dev Immunol 2012:827480. 2012..Taken together, these findings have shown that the increased frequency of circulating Tfh cells is correlated with elevated levels of anti-CCP antibody, indicating the possible involvement of Tfh cells in the disease progression of RA...
- Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravisBin Zhang
Department of Neurology, Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, 1120 15th St, Augusta, GA 30912, USA
Arch Neurol 69:445-51. 2012....
- Cellular and synaptic mechanisms of anti-NMDA receptor encephalitisEthan G Hughes
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 30:5866-75. 2010We recently described a severe, potentially lethal, but treatment-responsive encephalitis that associates with autoantibodies to the NMDA receptor (NMDAR) and results in behavioral symptoms similar to those obtained with models of genetic ..
- Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient miceMarie Laure Santiago-Raber
Department of Pathology and Immunology, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
J Autoimmun 34:339-48. 2010..these questions by assessing the effect of the TLR9 and/or TLR7 deletion on the production of various autoantibodies and the development of lupus nephritis in C57BL/6 mice congenic for the Nba2 (NZB autoimmunity 2) locus (B6...
- Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's diseaseRichard Dodel
Department of Neurology, Philipps University Marburg, D 35043 Marburg, Germany
J Neurosci 31:5847-54. 2011..Recently, we reported naturally occurring autoantibodies against Aβ (NAbs-Aβ) being reduced in Alzheimer's disease patients...
- Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravisAlexandra Pevzner
Department of Physiological Genomics, Institute for Physiology, Ludwig Maximilians University, Pettenkoferstrasse 12, 80336, Munich, Germany
J Neurol 259:427-35. 2012..Approximately 80% of all myasthenia gravis patients have autoantibodies against the nicotinic acetylcholine receptor in their serum...
- Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer seraJi Qiu
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Clin Oncol 26:5060-6. 2008We have implemented a high throughput platform for quantitative analysis of serum autoantibodies, which we have applied to lung cancer for discovery of novel antigens and for validation in prediagnostic sera of autoantibodies to antigens ..
- Apoptosis in the pathogenesis of systemic lupus erythematosusL E Munoz
Department of Internal Medicine 3, Institute for Clinical Immunology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
Lupus 17:371-5. 2008..Furthermore, phagocytosis of apoptotic cells may lead to a pro-inflammatory response in the presence of autoantibodies. This may sustain inflammatory conditions and the pathology found in overt lupus.
- Neuronal PAD4 expression and protein citrullination: possible role in production of autoantibodies associated with neurodegenerative diseaseNimish K Acharya
New Jersey Institute for Successful Aging NJISA at University of Medicine and Dentistry of New Jersey UMDNJ, School of Osteopathic medicine SOM, 2 Medical Center Drive, Stratford, NJ 08084, USA
J Autoimmun 38:369-80. 2012..that expression of PADs and protein citrullination plays a role in the production of brain-reactive autoantibodies that may contribute to Alzheimer's-related brain pathology...
- Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody productionSharon A Chung
Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, United States of America
PLoS Genet 7:e1001323. 2011..Lack of strong SNP associations may suggest that other types of genetic variation or non-genetic factors such as environmental exposures have a greater impact on susceptibility to anti-dsDNA - SLE...
- Clinical significance of anti-Ro52 (TRIM21) antibodies non-associated with anti-SSA 60kDa antibodies: results of a multicentric studyP Ghillani
Laboratoire d Immunochimie, Groupe Hospitalier Pitie Salpetriere, Paris, France
Autoimmun Rev 10:509-13. 2011..The presence of anti-Ro52 antibodies should probably precede development of autoimmune disease and must induce sequential follow-up of positive patients, particularly in interstitial lung disease progression...
- Investigations of caspr2, an autoantigen of encephalitis and neuromyotoniaEric Lancaster
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
Ann Neurol 69:303-11. 2011....
- Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndromeIain Moore
Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
Blood 115:379-87. 2010Factor H autoantibodies have been reported in approximately 10% of patients with atypical hemolytic uremic syndrome (aHUS) and are associated with deficiency of factor H-related proteins 1 and 3...
- Direct characterization of target podocyte antigens and auto-antibodies in human membranous glomerulonephritis: Alfa-enolase and borderline antigensMaurizio Bruschi
Division of Nephrology and Laboratory on Pathophysiology of Uremia, G Gaslini Children Hospital, Genoa, Italy
J Proteomics 74:2008-17. 2011..Circulating anti α-enolase auto-antibodies can be detected in sera of a significant quota of MGN patients. Like other auto-antigens, α-enolase may be implicated in the pathogenesis of human MGN...
- Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strainsB S Andrews
J Exp Med 148:1198-215. 1978..The common elements of lymphoid hyperplasia, B-cell hyperactivity, autoantibodies, circulating immune complex (IC), complement consumption, IC glomerulonephritis with gp70 deposition, and ..
- Clinical and laboratory aspects of Ro/SSA-52 autoantibodiesCaterina Defendenti
Laboratory Unit, Fatebenefratelli Hospital, Milan, Italy
Autoimmun Rev 10:150-4. 2011..Anti-Ro/SSA52 autoantibodies are more frequent than other autoantibodies possibly because of the antigen's accessible and ubiquitous nature...
- Pathogenesis of systemic lupus erythematosusC C Mok
Department of Medicine and Geriatrics, Tuen Mun Hospital, Tsing Chung Koon Road, New Territories, Hong Kong
J Clin Pathol 56:481-90. 2003..suppression, and the shifting of T helper 1 (Th1) to Th2 immune responses leads to B cell hyperactivity and the production of pathogenic autoantibodies. Finally, certain environmental factors are probably required to trigger the disease.
- IL-17 plays an important role in the development of experimental autoimmune encephalomyelitisYutaka Komiyama
Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
J Immunol 177:566-73. 2006..These observations indicate that IL-17 rather than IFN-gamma plays a crucial role in the development of EAE...
- Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigenEric Lancaster
Department of Neurology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
Lancet Neurol 9:67-76. 2010..Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features of one such disorder and to identify the autoantigen involved...
- Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degenerationXiaorong Gu
Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
J Biol Chem 278:42027-35. 2003..CEP-modified proteins, produced anti-CEP antibodies, and initiated analysis of CEP immunoreactivity and autoantibodies in human plasma...
- The sentinel within: exploiting the immune system for cancer biomarkersKaren S Anderson
Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Proteome Res 4:1123-33. 2005..These advances are opening the door for targeted vaccine development, and for using immune response signatures as biomarkers for cancer diagnosis and monitoring...
- Protective autoantibodies: role in homeostasis, clinical importance, and therapeutic potentialYehuda Shoenfeld
Department of Medicine B, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel
Arthritis Rheum 52:2599-606. 2005
- Risk factors for cardiovascular disease in systemic lupus erythematosusE Svenungsson
Department of Rheumatology and Centre for Molecular Medicine, King Gustaf V Research Institute, Karolinska Hospital, Stockholm, Sweden
Circulation 104:1887-93. 2001..We determined the prevalence of traditional and nontraditional risk factors for CVD in SLE patients with and without CVD compared with controls...
- Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosisFrancisco J Quintana
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:18889-94. 2008..RRMS was characterized by autoantibodies to heat shock proteins that were not observed in PPMS or SPMS...
- Laboratory testing in the diagnosis and management of idiopathic inflammatory myopathiesIra N Targoff
Department of Medicine, Veterans Affairs Medical Center, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Rheum Dis Clin North Am 28:859-90, viii. 2002..to assess muscle injury; (2) immunologic tests that detect markers of the disease process, including serum autoantibodies that have been associated with myositis; and (3) general laboratory tests that are used to assess the patient'..
- Autoimmune liver serology: current diagnostic and clinical challengesDimitrios P Bogdanos
Institute of Liver Studies, King s College London School of Medicine, London SE5 9RS, UK
World J Gastroenterol 14:3374-87. 2008Liver-related autoantibodies are crucial for the correct diagnosis and classification of autoimmune liver diseases (AiLD), namely autoimmune hepatitis types 1 and 2 (AIH-1 and 2), primary biliary cirrhosis (PBC), and the sclerosing ..
- Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosusCorinna E Weckerle
University of Chicago, Chicago, IL, USA
Arthritis Rheum 63:1044-53. 2011..This study was undertaken to detect associations between clinical and serologic disease manifestations and serum IFNα activity in a large diverse SLE cohort, using multivariate and network analyses...
- Mutation of DNASE1 in people with systemic lupus erythematosusK Yasutomo
Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima 770 8503, Japan
Nat Genet 28:313-4. 2001..These data are consistent with the hypothesis that a direct connection exists between low activity of DNASE1 and progression of human SLE...
- Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinasePhilip L Cohen
Department of Medicine, Division of Rheumatology, University of Pennsylvania, and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
J Exp Med 196:135-40. 2002..These mice should be an excellent model for studying the role of apoptotic debris as an immunogenic stimulus for systemic autoimmunity...
- Thyrotropin receptor autoantibodies are independent risk factors for Graves' ophthalmopathy and help to predict severity and outcome of the diseaseAnja K Eckstein
Department of Ophthalmology, Essen University Clinic, Hufelandstrasse 55, D 45122 Essen, Germany
J Clin Endocrinol Metab 91:3464-70. 2006..The objective of this study was to examine whether TSH-receptor antibody [TSH binding inhibitory antibodies (TBII)] levels are associated with the severity of Graves' ophthalmopathy (GO) over the entire course of the disease...
Research Grants107 found, 100 shown here
- IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICEChella David; Fiscal Year: 2009..These mice will be evaluated for in vivo arthritis, autoantibodies and function of T and B cells...
- Predictors of Pregnancy Outcome in SLE and APSJane E Salmon; Fiscal Year: 2012..In addition to causing placental dysfunction, maternal autoantibodies may also directly impair fetal brain development...
- Maternal Autoantibodies: Pathogenesis of Neonatal LupusJILL PAMELA BUYON; Fiscal Year: 2013..predicts with near certainty that the mother, who may have a rheumatic disease or be asymptomatic, will have autoantibodies (Ab) to SSA/Ro ribonucleoproteins...
- Complement Activation in Pregnancy and HypertensionJean F Regal; Fiscal Year: 2013..Studies of preeclampsia have focused on mediators of hypertension including autoantibodies to angiotensin II type I receptor (AT1-AA) and anti-angiogenic factors such as soluble fms-like tyrosine ..
- Epigenetic downregulation of the antibody response and inhibition of autoimmunityPaolo Casali; Fiscal Year: 2013..mediate autoimmunity, including systemic lupus (SLE), in which heavily mutated and class-switched (mainly IgG) autoantibodies to nuclear antigens, as secreted by large numbers of plasma cells, produce widespread tissue and organ injury...
- Suppression of pathogenic autoantibodies in lupus by inhibition of AIDJohn D Mountz; Fiscal Year: 2012..lead to upregulation of activation-induced cytidine deaminase (AID) and the production of highly pathogenic autoantibodies. The significance of these studies lies in the identification of a mechanistic link between IL-17 and ..
- IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICEVeena Taneja; Fiscal Year: 2013..These mice will be evaluated for in vivo arthritis, autoantibodies and function of T and B cells...
- Gene Transcription in SLEGeorge C Tsokos; Fiscal Year: 2012..We also demonstrated that anti-CD3/TCR autoantibodies activate calcium/calmodulin kinase IV (CaMKIV) which is found primarily in the nucleus where it phosphorylates ..
- Macrophage-based Human Gene Therapy for Hereditary PAPBruce C Trapnell; Fiscal Year: 2012..of the GM-R (GM-R[unreadable]KO mice) or in GM-CSF (GMKO mice), and in humans with neutralizing GM-CSF autoantibodies (autoimmune PAP), all of which result in pulmonary histopathology and molecular pathology similar to ..
- Impact of smoking on immune response and arthritis in humanized miceVeena Taneja; Fiscal Year: 2011..These humanized mice mimic rheumatoid arthritis in pathology and autoantibodies. Arthritic mice produce autoantibodies like rheumatoid factor and anti-cyclic citrullinated peptide antibodies ..
- Gender Bias in Lupus: Contribution of Sex ChromosomesRam Raj Singh; Fiscal Year: 2012..will be ascertained using disease measures (proteinuria, creatinine, blood urea nitrogen and renal pathology), autoantibodies and immune responses...
- ANIMAL MODELS OF HYPERTHYROIDISMSandra M McLachlan; Fiscal Year: 2012..disorder, has an unusual etiology: the immune system targets one molecule, the thyrotropin receptor (TSHR), autoantibodies mediate disease, and the target organ is stimulated not destroyed...
- CNS Demyelinating Autoimmunity Targeting Water Channel ComplexesSEAN JOSEPH PITTOCK; Fiscal Year: 2013..This study aims to 1) determine the frequency of autoantibodies targeting aquaporin-4 or its partner proteins and how often this condition is misdiagnosed and mistreated as ..
- Endothelial-reactive antibodies: a diagnostic test for Susac's syndromeWILLIAM JAMES WALDMAN; Fiscal Year: 2011..10 SS patients, are designed to test the hypotheses that SS patients harbor circulating endothelial-reactive autoantibodies, and that the protein targets of these antibodies, once identified, can be exploited for the development of a ..
- Proteome Bead-Display for Discovery of Tumor AntigensMark Lim; Fiscal Year: 2013..One of the most promising candidates for such biomarkers is tumor-associated autoantigens (TAA), autoantibodies to which have been detected in patient's blood even in the early stages of cancer...
- HEPATIC DEGRADATION OF CYTOCHROME P450 ENZYMESMaria Almira Correia; Fiscal Year: 2013..to the outer plasma membrane, whereupon it is recognized by the immune surveillance system, engendering pathogenic autoantibodies clinically associated with alcoholic liver disease, drug-induced hepatitis, and hypersensitivity syndromes.
- Autoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targetsYang Xia; Fiscal Year: 2010..compelling, hypothesis that key clinical features of preeclampsia (PE) are due to the presence of pathogenic autoantibodies that activate the major angiotensin receptor, AT1...
- HLA-D Region in Systemic Lupus Erythematosus PathogenesisShu Man Fu; Fiscal Year: 2013..Our research in lupus genetics and the mechanism of diversification of lupus related autoantibodies and the insight gained in taking care of these patients led us to postulate the hypothesis that takes into ..
- Role of Estrogen Receptors in Lupus-Modulators of the Inflammatory ResponseGary S Gilkeson; Fiscal Year: 2013..and pathologic renal disease and had significantly prolonged survival, despite increased serum levels of autoantibodies. These findings led us to postulate that the primary impact of ER[unreadable] deficiency in lupus nephritis ..
- Regulation of the anti-phospholipid response in SLEAnne Davidson; Fiscal Year: 2013..T cell help is required for initial activation of anti-phospholipid B cells and induction of high affinity IgG autoantibodies. Our proposal is based on the following hypotheses: 1) Over-expression of TLR7 alters either B cell selection ..
- PET Imaging Agent for Diabetes MellitusJOGESH MUKHERJEE; Fiscal Year: 2010..Methods to predict the development of clinical T1DM currently rely on the detection of multiple autoantibodies to islet- associated proteins combined with HLA genotyping...
- High Throughput Screening of the Autoimmune EpitomeNancy J Olsen; Fiscal Year: 2010..They will then be used to measure and characterize autoantibodies from subjects with clinically evident SLE as well as those with early or incomplete forms of the disease...
- Developing Novel Serological Biomarkers for Autoimmune Liver DiseasesXuhang Li; Fiscal Year: 2013..Most of the current AILD biomarkers are autoantibodies, such as ANA/SMA for type-1 AIH;AMA for PBC (no specific PSC marker), suggesting that serum autoantibodies are ..
- Naturally Occurring IgM Anti-Leucocyte Autoantibodies Protect Against Renal IRIMARK DOUGLAS OKUSA; Fiscal Year: 2013..overall goal of this multi-PI proposal is to investigate the role of naturally occurring IgM anti-leucocyte autoantibodies in inhibiting inflammatory processes that occur after ischemia-reperfusion injury (IRI)...
- Atrial Fibrillation in Hyperthyroidism: Active Antibodies to Autonomic ReceptorsDAVID KEM; Fiscal Year: 2013..patients with autoimmune Graves'hyperthyroidism and atrial fibrillation (AF) have coexisting activating autoantibodies (AA) to the beta1-adrenergic (B1AR) and M2 muscarinic receptors (M2R)...
- Anti-Phospholipid Multiplex For Pathologic EpitopesPaul O Neilsen; Fiscal Year: 2010..Diagnosis of APS is complicated due to the heterogeneity of types of autoantibodies produced and their specific target antigens...
- Development of New Molecular Probes for Diagnostic Imaging of AtherosclerosisKAREN CATHERIN BRILEY SAEBO; Fiscal Year: 2010..Since OxLDL is immunogenic, autoantibodies that specifically bind oxidation-specific epitopes have been isolated from mice (MDA2 and E06) and humans (..
- Antibody Mediated Autoimmunity in Neuromyelitis OpticaHANS CHRISTIAN VON BUEDINGEN; Fiscal Year: 2013..It is unclear whether antigens other than AQP4 are also targets of pathologically relevant autoantibodies and no information is available regarding epitope targets of pathogenic autoantibodies in anti- AQP4 ..
- Predictive Ability of Gene Expression Signatures In Skin as SSc BiomarkersMONIQUE EVANGELINE HINCHCLIFF; Fiscal Year: 2013..Current SSc classification systems based upon serum autoantibodies and extent of skin fibrosis are unreliable biomarkers to predict disease course or treatment response...
- The Effects of C-Reactive Protein on AutoimmunityTerry W Du Clos; Fiscal Year: 2013..Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by autoantibodies against nuclear antigens...
- Developing small molecule therapeutics for lupusThomas R Coleman; Fiscal Year: 2012..SLE is characterized by the production of autoantibodies, many of which have specificity for nuclear antigens, in particular, DNA...
- Proteomic Identification of Actionable Biomarkers in Rheumatoid ArthritisWilliam H Robinson; Fiscal Year: 2010..microarray analysis revealed the targeting of a variety of candidate native and citrullinated antigens by autoantibodies in established RA...
- Post Translational Modifications in Tolerance and AutoimmunityMark J Mamula; Fiscal Year: 2012..With relevance to our work, autoantibodies to other protein modifications, notably citrulline proteins, have become diagnostic for autoimmune syndromes ..
- Caspase 8: A Novel Suppressor of Dendritic Cell-Mediated AutoimmunityCarla M Cuda; Fiscal Year: 2013..lupus erythematosus (SLE) is a multi-organ and destructive autoimmune disease characterized by pathogenic autoantibodies. While it has been accepted that dendritic cells play an important role in the initiation of the disease, only ..
- B cell metabolism in activation and autoantibody productionJeffrey C Rathmell; Fiscal Year: 2013..As autoantibodies promote a variety of SLE-associated pathologies, including immune complex formation and deposition responsible ..
- Progesterone &Estrogen Differentially Regulate DC Function in Lupus AutoimmunityGrant Hughes; Fiscal Year: 2012..In SLE, however, immune complexes (ICs) comprised of autoantibodies (autoAbs) and nuclear antigens (Ags), through TLRs 7 and 9, activate myeloid DCs (mDCs) and stimulate ..
- Bacterial peptidylarginine deiminase, a link between gums and joint diseaseJAN S POTEMPA; Fiscal Year: 2013..proteins at periodontitis sites may also predispose susceptible individuals to the development of autoantibodies and initiation of RA...
- Role of B cells in pathogenesis of Collagen-induced Arthritis in Humanized MiceVeena Taneja; Fiscal Year: 2012..Females have hyperactive B cells which contribute towards the development of autoantibodies and presentation of antigens to T cells leading to increased incidence in females...
- Syk blockade in bullous skin diseasesUma Sinha; Fiscal Year: 2012..two direct therapeutic actions important for BP pathogenesis;1) reduction of the BCR-triggered production of autoantibodies, and 2) uncoupling of the FcR-mediated triggering of the inflammatory response...
- STUDIES ON THE STRUCTURE OF BASEMENT MEMBRANESBILLY GERALD HUDSON; Fiscal Year: 2013..Aim 4: To characterize the heterogeneity of 13 GP and 15 GP autoantibodies. We have recently determined that the a5 Gp autoantibodies, in addition to the well-known a3 GP autoantibodies ..
- The Role of IgE in Autoimmune Skin DiseasesJanet A Fairley; Fiscal Year: 2013..by applicant): Bullous pemphigoid (BP) is a blistering disease of the skin characterized by development of autoantibodies directed against BP180, a cell-substrate attachment protein...
- Role of GM-CSF in Myeloid Cell Function and Innate ImmunityBruce C Trapnell; Fiscal Year: 2013..and AM functions, and innate immunity, and that in ~90% of patients, PAP is caused by a high level of GM-CSF autoantibodies (GMAbs). Current evidence suggests GM-CSF regulates surfactant homeostasis via the transcription factors PU...
- A Mouse Model for Emotional Disorder Caused by Mild Traumatic Brain InjuryANTON J REINER; Fiscal Year: 2013..and serological assessments of biomarkers that are predictive and perhaps causally related (for example, autoantibodies against neural antigens) to the process causing secondary brain damage...
- Regulation of the anti-phospholipid response in SLEAnne Davidson; Fiscal Year: 2009..T cell help is required for initial activation of anti-phospholipid B cells and induction of high affinity IgG autoantibodies. We hypothesize that immune complex formation and opsonization of apoptotic particles by IgG anti-phospholipid ..
- Proteomics Biomarkers Development LaboratorySamir Hanash; Fiscal Year: 2009..cancer, indicating the utility of assays of specific circulating tumor protein antigens or their corresponding autoantibodies, for the early detection of cancer...
- Somatic hypermutation and class switching in autoimmunityPaolo Casali; Fiscal Year: 2013..Like antibodies to microbial pathogens, most pathogenic autoantibodies are somatically hypermutated and class-switched...
- Preventive Approach to Congenital Heart Block with Hydroxychloroquine (PATCH)JILL PAMELA BUYON; Fiscal Year: 2013DESCRIPTION (provided by applicant): One of the strongest clinical associations with autoantibodies directed to components of the Ro/La ribonucleoprotein complex is the development of congenital heart block (CHB) in an offspring, an ..
- MECHANISMS AND PATHOGENESIS OF PRIMARY BILIARY CIRRHOSISMERRILL E GERSHWIN; Fiscal Year: 2013..by a targeted immune response to small biliary epithelial cells (BEC) and the presence of antimitochondrial autoantibodies (AMAs), which react specifically with the lipoyl domain of the pyruvate dehydrogenase complex E2 subunit (PDC-..
- Multi-Ethnic Study of Autoimmunity and Cardiovascular DiseaseDarcy S Majka; Fiscal Year: 2013..CTD-related autoantibodies have been identified in individuals years before they develop rheumatoid arthritis and lupus, but most ..
- A protein array platform for anti-citrulline antibodies in Rheumatoid ArthritisJi Qiu; Fiscal Year: 2013..Recent studies demonstrated the value of identifying autoantibodies to particular antigens in the elucidation of RA etiology...
- CENTER FOR CANCER BIOLOGY RESEARCHW Keith Miskimins; Fiscal Year: 2011..This information will be used to develop a new diagnostic test for prostate cancer that detects autoantibodies in patient serum...
- Regulation of Migration of Autoreactive Germinal Centers and Precursor B CellsJohn D Mountz; Fiscal Year: 2013..PUBLIC HEALTH RELEVANCE: Short Narrative Autoantibodies play a critical role in the development of autoimmune diseases such as rheumatoid arthritis and systemic lupus ..
- Disconnecting CR2/CD21 from Its C3d Ligand to Ameliorate LupusVERNON MICHAEL HOLERS; Fiscal Year: 2013..High affinity autoantibodies and B lymphocytes play central roles in the immunopathogenesis of human systemic lupus erythematosus (SLE)...
- Clinical Risk Prediction Modeling in Rheumatoid ArthritisElizabeth W Karlson; Fiscal Year: 2013..Identification of autoantibodies and cytokines present many years prior to RA onset provides an exciting opportunity to intervene during the ..
- B CELL HYPERACTIVITY IN AUTOIMMUNITYAnn Marshak Rothstein; Fiscal Year: 2010..It is characterized by the excessive production of a wide range of autoantibodies specific for self antigens such as chromatin, ribonucleoproteins and phospholipids...
- Novel Biomarkers and Causal Pathways in RA SusceptbilityKaren H Costenbader; Fiscal Year: 2013..Premature immunosenescence with aberrant recognition of self-antigens may be central to RA development. Autoantibodies to citrullinated peptides are increasingly recognized as specific biomarkers, and potentially contributing ..
- CD19 Tyrosine-mediated Signal Transduction in vivoLouis B Justement; Fiscal Year: 2012..cell surface receptor, fail to form marginal zone B cells or germinal centers and have a propensity to produce autoantibodies. Our new data demonstrate that lack of marginal zone B cells results in defects in other components of the ..
- Dissection of the ACPA response in African-Americans with Rheumatoid ArthritisS Louis Bridges; Fiscal Year: 2013..g. smoking and exposure to exogenous and self-antigens). RA is characterized by serum autoantibodies, including anti-citrullinated peptide/protein antibodies (ACPA), measured clinically by the anti-cyclic ..
- Immune-pathophysiology of lymphocytic foci in Sjogren's syndromeCuong Q Nguyen; Fiscal Year: 2010..Recent studies suggest that B cells and autoantibodies play a critical role in onset of exocrine glandular dysfunction...
- ETIOLOGY AND PATHOGENESIS OF PEMPHIGUSLuis A Diaz; Fiscal Year: 2013..This epidermal-specific autoimmune disease is mediated by pathogenic IgG4 anti-desmoglein 1 (Dsg1) autoantibodies. In 1994, we identified the Amerindian Reservation of Limao Verde (LV), Brazil composed of ~1,400 individuals ..
- CENTER FOR CANCER BIOLOGY RESEARCHW Keith Miskimins; Fiscal Year: 2013..This information will be used to develop a new diagnostic test for prostate cancer that detects autoantibodies in patient serum...
- Antigen Identification in a Novel Model of Spontaneous Autoimmune Ovarian DiseaseMickie H Cheng; Fiscal Year: 2012..Autoimmunity is manifested by development of antigen-specific autoantibodies, organ infiltration, and transfer of disease by lymphocytes from affected aire KO mice...
- PATHOGENESIS OF AUTOANTIBODIES IN PRISTANE-INDUCED LUPUSWestley H Reeves; Fiscal Year: 2013..p. injection of tetramethylpentadecane (TMPD, pristane), anti-Sm/RNP and anti-DNA autoantibodies are induced and immune complex-mediated glomerulonephritis develops...
- Outcomes Research in Rheumatic DiseasesDinesh Khanna; Fiscal Year: 2013..S. scleroderma centers. The goals of the registry include: i) to determine whether the clinical phenotypes and autoantibodies at baseline in early, diffuse scleroderma are associated with, and predict, clinical, radiological, and ..
- The role of peroxidasin in Goodpasture's diseaseABRAHAM SCOTT MCCALL; Fiscal Year: 2013..crosslinked by a sulfilimine chemical bond (-S=N-), which renders the NC1 hexamer inert to binding of GP autoantibodies. This bond is formed by the recently identified enzyme peroxidasin (PXDN) which putatively utilizes hydrogen ..
- Carbohydrate Antigenic Biomarkers for Epithelial CancersMinoru Fukuda; Fiscal Year: 2013..This will open the way to analysis of cancer patient sera for the presence of autoantibodies to F77 and AE3 and any other glycan biomarkers and to the design of new analysis procedures for the detection ..
- Study of FcR Genes: Macrophages and LymphocytesJEFFREY VICTOR RAVETCH; Fiscal Year: 2013DESCRIPTION (provided by applicant): The loss of tolerance to self-antigens with the resultant accumulation of autoantibodies and pathogenic immune complexes is a hallmark of many autoimmune diseases and contributes to their pathological ..
- Interferons and cytotoxic lymphocytes in dermatomyositis and cutaneous lupusDAVID FRANKLIN FIORENTINO; Fiscal Year: 2013..recent studies have identified a distinct cutaneous phenotype (in seronegative DM patients) associated with autoantibodies to MDA5, an autoantigen regulated by type I IFNs and cleaved during lymphocyte-mediated cytotoxicity...
- Glycoproteins and Glycan-Binding IgGs: Biomarkers for Cancer and Inflammatory DiHyesook Kim; Fiscal Year: 2013..Identification of prostate cancer- specific glycans recognized by autoantibodies will lead to development of glycan-based therapeutics.
- A role for IL-1 in SJIA monocyte phenotypes: A RAPPORT ancillary studyElizabeth D Mellins; Fiscal Year: 2013..activation syndrome and amyloidosis support involvement of the innate immune system, as do the paucity of autoantibodies or MHC alleles that predispose to disease...
- GENETIC ANALYSIS OF LUPUS AUTOIMMUNITYJudith James; Fiscal Year: 2000..anti-nRNP antibodies; the peptides used as immunogens were selected since they are also bound by human lupus autoantibodies. The peptide-immunized rabbits, in addition to anti-Sm and anti-nRNP antibodies, also develop positive ANA, ..
- Pancreas Volume in Preclinical Type 1 DiabetesMartha L Campbell-Thompson; Fiscal Year: 2013..profound, reductions in pancreas weight were also observed in organ donors with only single diabetes-related autoantibodies. These findings underscore that changes in pancreas weight may represent an early event in the pathogenesis of ..
- Preventive Interventions Leadership U01Samir M Hanash; Fiscal Year: 2013..mouse models of breast cancer to identify tumor antigens that induce an immune response in the form of autoantibodies that can be used for early diagnosis of breast cancer and that have potential for vaccine development...
- Pathways of plasma cell differentiation in autoimmunityLoren D Erickson; Fiscal Year: 2013..is to directly assess the role of BCMA in the regulation of plasma cell (PC) survival and the development of autoantibodies. BCMA is a member of the TNF receptor family and was first described by our group as a critical receptor on ..
- XENOBIOTICS AND PRIMARY BILIARY CIRRHOSISMERRILL E GERSHWIN; Fiscal Year: 2013..This thesis is based on our analysis of the reactivity of anti-mitochondrial autoantibodies (AMA) to specific xenobiotic chemicals utilizing tools of quantitative structure activity relationships (QSAR)...
- Discovery of Novel Autoantigens in Patients with Inclusion Body MyositisKEVIN C O'CONNOR; Fiscal Year: 2013..In the second part of the project, the sero-prevalence of IBM autoantibodies will be determined...
- Rituximab Therapy in Patients with IPFKEVIN FITZGERALD GIBSON; Fiscal Year: 2013..Recent findings of our research group, as well as others, show that autoantibodies are associated with IPF progression...
- Initiating Events in AMD: a mouse model for the human diseaseJOE GILBERT HOLLYFIELD; Fiscal Year: 2013..In addition, autoantibodies against CEP were more abundant in the circulation (plasma) of individuals with AMD than in age-matched ..
- ANCA GLOMERULONEPHRITIS: FROM MOLECULES TO MANRonald J Falk; Fiscal Year: 2013Glomerulonephritis and vasculitis caused by anti-neutrophil cytoplasmic autoantibodies (ANCA) Is the most common form of rapidly progressive glomerular disease...
- Novel Neutrophil Autoantigens in Systemic Lupus ErythematosusKaihong Su; Fiscal Year: 2013..Based on these results, we hypothesize that a subset of autoantibodies from SLE patients recognizes neutrophil antigens and activates neutrophils, which contributes to tissue damage ..
- Role of transglutaminase 2 in celiac sprueChaitan Khosla; Fiscal Year: 2013..TG2 is also the primary target of autoantibodies in celiac disease...
- A+PSA Assay for Improved Prostate Cancer Diagnosis and Risk AssessmentGang Zeng; Fiscal Year: 2013DESCRIPTION (provided by applicant): Circulating autoantibodies (autoAb) against tumor-associated antigens (TAA) provide critical information about the immunocompetence of the host and the immunogenicity of the endogenously arising tumor...
- The Role of the Lung in the Initiation of Rheumatoid ArthritisKevin D Deane; Fiscal Year: 2013..It is now well-established that RA-related autoantibodies (Abs) may be elevated in blood years prior to the onset of symptomatic inflammatory arthritis (IA), with this ..
- The endosomal SLC15A4 proton-coupled histidine transporter in lupusArgyrios N Theofilopoulos; Fiscal Year: 2013..by applicant): Systemic lupus erythematosus in humans and spontaneous mouse models is characterized by autoantibodies to nuclear and cytoplasmic materials that contain RNA, DNA or both, and considerable evidence indicates a ..
- Autoantibody and BCR peptide-specific T cells in lupus nephritisJAMES BEN ST CLAIR; Fiscal Year: 2013..However, the mechanisms by which T cells are primed, the specificity of renal T cells, and how autoantibodies are initially elicited are still large unanswered questions...
- Lupus Glomenulonephritis and NK T cellsSamuel Strober; Fiscal Year: 2013..cell surface, and induce polyclonal activation of the B cells with secretion of IgM, IgG and IgG anti-dsDNA autoantibodies. Conventional CD4+ T cells (non-NK T cells) have little helper activity for antibody secretion...
- Protein Markers to T1D ProgressionQibin Zhang; Fiscal Year: 2013..Currently, autoantibodies to islet cell antigens serve to identify those at increased risk for T1D, yet additional biomarkers are ..
- A Novel Approach Applying CGM Metrics to Identify a Prediabetic StateMASSIMO T PIETROPAOLO; Fiscal Year: 2013..These subjects are longitudinally followed and deeply phenotyped with respect to multiple islet-related autoantibodies, HLA genotyping, metabolic assessment and many other risk factors...
- Role of Interleukin 14 in Sjogren's DiseaseJulian L Ambrus; Fiscal Year: 2013..of Sj"gren's disease will be evaluated with and without therapy, including hypergammaglobulinemia, autoantibodies, loss of salivary gland secretions and infiltration of salivary glands and lungs with lymphocytes...
- Large-Scale Characterization of Autoantibody Responses in Rheumatoid ArthritisWilliam H Robinson; Fiscal Year: 2013..5% of the world population, yet the key autoantigen targets remain unknown. Production of autoantibodies, such as the anti-citrullinated protein antibodies (ACPAs), is a hallmark of RA...
- Development of a novel biomarker test for autism risk screeningSergei Svarovsky; Fiscal Year: 2013..To evaluate the immunoreactivity of the endogenous autoantibodies from mothers of children with autism and typically developing controls against these expressed proteins...
- PAD2: An Arginine Deiminase that Regulates ArthritisKerri A Mowen; Fiscal Year: 2013..PAD enzymes have been implicated in RA pathology because many RA autoantibodies are directed against citrullinated proteins...
- Markers of Beta Cell Dysfunction and Hypoglycemia in ACCORDElizabeth R Seaquist; Fiscal Year: 2013..Aim 1b: To measure baseline autoantibodies to GAD 65 (GAD), intracytoplasmic domain of the tyrosine phosphatase-like protein IA-2 (IA-2A) and insulin (..
- MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITYKai Wucherpfennig; Fiscal Year: 2001..In PV patients, autoantibodies against a keratinocyte adhesion molecule, desmoglein 3, inhibit desmoglein 3-mediated kearatinocyte adhesion ..
- Role of CD48:CD244 Pathway in Systemic Lupus ErythematosusDANIEL RABIN BROWN; Fiscal Year: 2013..Study the role of CD244 in mediating T cell and B cell tolerance. CD244-/- mice spontaneously develop autoantibodies. When CD244-/- mice were bred to the Y-linked autoimmune accelerator locus (Yaa), the resulting strain ..
- Nelfinavir in SLE: A Pilot Phase IIa Clinical TrialBetty Diamond; Fiscal Year: 2013..data demonstrating that nelfinavir acts, in part, as a decoy antigen to quench the pathogenic lupus anti-dsDNA autoantibodies, we propose to assess the safety and preliminary efficacy of nelfinavir as a lupus therapeutic in a pilot ..
- Zinc Transporter-8-Specific T Cell Responses in the Prediction of Type 1 DiabetesHELENA KRISTIINA REIJONEN; Fiscal Year: 2013..for progression to T1D, and that appearance of Zn-T8-specific T cells may precede the emergence of Zn-T8 autoantibodies. The relationship and hierarchy between Zn-T8-specific T cell responses and other biochemical autoantibodies (..
- ANTIBODIES WITH PROTHROMBINASE ACTIVITY IN LUPUSPerumal Thiagarajan; Fiscal Year: 2003Prothrombin is the precursor of thrombin, the central enzyme in blood coagulation. Prothrombin binding autoantibodies from lupus patients are clinically associated with thrombosis, but the association is paradoxical, because conventional ..
- A Novel Genetic Model of Systemic Lupus ErythematosusBoris Reizis; Fiscal Year: 2013..by applicant): Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of autoantibodies against nucleic acids, most prominently against double-stranded DNA (dsDNA)...
- Autoimmunity in Rag Deficiency: A Nexus of Immunodeficiency and DysregulationJolan E Walter; Fiscal Year: 2013..B cell repertoire at distinct stages of B cell maturation with or without the use of anti- BAFF monoclonal autoantibodies would allow us to compare the relative importance of the disruption in central versus peripheral tolerance ..
- Interactions of lgC4 &lgE anti-Dsg1 Autoantibodies in Endemic Pemphigus FoliaceuYe Qian; Fiscal Year: 2013..Additionally, this K01 Award will promote the career advancement of the applicant and help him to achieve research independence. ..