immunoglobulins

Summary

Summary: Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.

Top Publications

  1. pmc Structure and function of immunoglobulins
    Harry W Schroeder
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    J Allergy Clin Immunol 125:S41-52. 2010
  2. ncbi The impact of glycosylation on the biological function and structure of human immunoglobulins
    James N Arnold
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Annu Rev Immunol 25:21-50. 2007
  3. pmc Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5
    Rushad Pavri
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Cell 143:122-33. 2010
  4. ncbi SynCAM, a synaptic adhesion molecule that drives synapse assembly
    Thomas Biederer
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 297:1525-31. 2002
  5. pmc IgT, a primitive immunoglobulin class specialized in mucosal immunity
    Yong an Zhang
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Nat Immunol 11:827-35. 2010
  6. ncbi Camelid immunoglobulins and nanobody technology
    S Muyldermans
    Laboratory of Cellular and Molecular Immunology, Department of Molecular and Cellular Interactions, VIB, Vrije Universiteit Brussel, Brussels, Belgium
    Vet Immunol Immunopathol 128:178-83. 2009
  7. ncbi Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration
    Patricia F Maness
    Department of Biochemistry and Biophysics and Neuroscience Research Center, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
    Nat Neurosci 10:19-26. 2007
  8. pmc Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration
    I Martin-Padura
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Cell Biol 142:117-27. 1998
  9. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
  10. ncbi Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells
    Tomohiko Wakayama
    Department of Histology and Embryology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Biol Reprod 76:1081-90. 2007

Detail Information

Publications308 found, 100 shown here

  1. pmc Structure and function of immunoglobulins
    Harry W Schroeder
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    J Allergy Clin Immunol 125:S41-52. 2010
    b>Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains...
  2. ncbi The impact of glycosylation on the biological function and structure of human immunoglobulins
    James N Arnold
    Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Annu Rev Immunol 25:21-50. 2007
    b>Immunoglobulins are the major secretory products of the adaptive immune system. Each is characterized by a distinctive set of glycoforms that reflects the wide variation in the number, type, and location of their oligosaccharides...
  3. pmc Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5
    Rushad Pavri
    Laboratory of Molecular Immunology, The Rockefeller University, New York, New York 10065, USA
    Cell 143:122-33. 2010
    ..Further, Spt5 accumulation at sites of Pol II stalling is predictive of AID-induced mutation. We propose that AID is targeted to sites of Pol II stalling in part via its association with Spt5...
  4. ncbi SynCAM, a synaptic adhesion molecule that drives synapse assembly
    Thomas Biederer
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 297:1525-31. 2002
    ....
  5. pmc IgT, a primitive immunoglobulin class specialized in mucosal immunity
    Yong an Zhang
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Nat Immunol 11:827-35. 2010
    Teleost fish are the most primitive bony vertebrates that contain immunoglobulins. In contrast to mammals and birds, these species are devoid of immunoglobulin A (IgA) or a functional equivalent...
  6. ncbi Camelid immunoglobulins and nanobody technology
    S Muyldermans
    Laboratory of Cellular and Molecular Immunology, Department of Molecular and Cellular Interactions, VIB, Vrije Universiteit Brussel, Brussels, Belgium
    Vet Immunol Immunopathol 128:178-83. 2009
    ..We have successfully developed recombinant Nbs for research purposes, as probe in biosensors, to diagnose infections, and to treat diseases like cancer or trypanosomosis...
  7. ncbi Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration
    Patricia F Maness
    Department of Biochemistry and Biophysics and Neuroscience Research Center, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27599 7260, USA
    Nat Neurosci 10:19-26. 2007
    ....
  8. pmc Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration
    I Martin-Padura
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Cell Biol 142:117-27. 1998
    ..Thus, JAM is a new component of endothelial and epithelial junctions that play a role in regulating monocyte transmigration...
  9. ncbi BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator
    P A Moore
    Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA
    Science 285:260-3. 1999
    ..The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation...
  10. ncbi Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells
    Tomohiko Wakayama
    Department of Histology and Embryology, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8640, Japan
    Biol Reprod 76:1081-90. 2007
    ..These findings suggest that the heterophilic binding of PVR to IGSF4A is responsible, at least in part, for the interaction between Sertoli and spermatogenic cells during mouse spermatogenesis...
  11. ncbi Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells
    Vanessa L Bryant
    Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
    J Immunol 179:8180-90. 2007
    ..These findings suggest that IL-21 produced by TFH cells during the primary as well as the subsequent responses to T cell-dependent Ag makes a major contribution to eliciting and maintaining long-lived humoral immunity...
  12. pmc The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo
    Abigail Woodfin
    William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
    Nat Immunol 12:761-9. 2011
    ..Our results identify JAM-C as a key regulator of polarized neutrophil TEM in vivo and suggest that reverse TEM of neutrophils can contribute to the dissemination of systemic inflammation...
  13. ncbi An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
    B Schiemann
    Biogen, 14 Cambridge Center, Cambridge, MA 02142, USA
    Science 293:2111-4. 2001
    ..In contrast, mice lacking BCMA had normal-appearing B lymphocyte compartments. BAFF therefore plays a crucial role in B cell development and can function through receptors other than BCMA...
  14. ncbi The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs
    Naokazu Inoue
    Genome Information Research Center, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    Nature 434:234-8. 2005
    ..Human sperm also contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamster eggs...
  15. ncbi The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves
    Tadahide Furuno
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
    J Immunol 174:6934-42. 2005
    ..At points of contact between neurites and wild-type BMMC, SgIGSF/SynCAM was locally concentrated in both neurites and BMMC. SgIGSF/SynCAM on mast cells appeared to predominantly mediate attachment and promote communication with nerves...
  16. ncbi Immunodeficiency in protein kinase cbeta-deficient mice
    M Leitges
    Max Delbruck Laboratorium in der Max Planck Gesellschaft, Carl von Linne Weg 10, D 50829 Köln, Germany
    Science 273:788-91. 1996
    ..Thus PKC-betaI and PKC-betaII play an important role in B cell activation and may be functionally linked to Bruton's tyrosine kinase in antigen receptor-mediated signal transduction...
  17. ncbi SynCAMs organize synapses through heterophilic adhesion
    Adam I Fogel
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 27:12516-30. 2007
    ..Our results define SynCAM proteins as components of novel heterophilic transsynaptic adhesion complexes that set up asymmetric interactions, with SynCAM proteins contributing to synapse organization and function...
  18. ncbi Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
    C Berlin
    Department of Pathology, Stanford University, California 94305
    Cell 74:185-95. 1993
    ..Alpha 4 beta 7 can also bind VCAM-1, but this requires greater integrin activation than binding to MAdCAM-1. The findings imply a selective role for the interaction of alpha 4 beta 7 and MAdCAM-1 lymphocyte in homing to mucosal sites...
  19. ncbi Impairment of social and emotional behaviors in Cadm1-knockout mice
    Yuki Takayanagi
    Department of Physiology, Jichi Medical University, 3311 1 Yakushiji, Shimotsuke shi, Tochigi Ken 329 0498, Japan
    Biochem Biophys Res Commun 396:703-8. 2010
    ....
  20. ncbi Mutations in the gene encoding CADM1 are associated with autism spectrum disorder
    Yu Zhiling
    Department of Pediatrics, Jichi Medical University, 3311 1 Yakushiji, Shimotsukeshi, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 377:926-9. 2008
    ..Our findings provide key support for the unified idea that impaired synaptogenesis underlies the pathogenesis of ASD...
  21. ncbi Immunoglobulins, antibody repertoire and B cell development
    J E Butler
    Department of Microbiology, University of Iowa, Iowa City, IA, USA
    Dev Comp Immunol 33:321-33. 2009
    ..This chapter traces the study of the humoral immune system of this species through its various eras of discovery and compiles the results in tables and figures that should be a useful reference for educators and investigators...
  22. ncbi Function and histopathology of a cell adhesion molecule TSLC1 in cancer
    Qi lian Liang
    Department of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China
    Cancer Invest 29:107-12. 2011
    ..On the basis of these, we propose that TSLC1 represents a promising biomarker for cancer diagnosis and a potential target for cancer therapy...
  23. ncbi Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily
    L J Zhou
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 154:3821-35. 1995
    ..Thus, CD83 serves as a useful and specific marker for this unique population of human blood dendritic cells...
  24. pmc B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
    Danielle T Avery
    Immunology Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    J Exp Med 207:155-71. 2010
    ..STAT3-activating cytokines such as IL-21 thus underpin Ag-specific humoral immune responses and provide a mechanism for the functional antibody deficit in STAT3-deficient patients...
  25. ncbi Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells
    Tatsushi Shingai
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Osaka, Japan
    J Biol Chem 278:35421-7. 2003
    ..These results indicate the unique localization of Necl-2 and its possible involvement in localization of a transmembrane protein(s) through Pals2...
  26. ncbi Development of a human adaptive immune system in cord blood cell-transplanted mice
    Elisabetta Traggiai
    Institute for Research in Biomedicine IRB, Via Vela 6, 6500 Bellinzona, Switzerland
    Science 304:104-7. 2004
    ..This provides a valuable model to study development and function of the human adaptive immune system in vivo...
  27. ncbi Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus
    M Odendahl
    Deutsches Rheuma ForschungsZentrum Berlin, Charite University Hospital, Berlin, Germany
    J Immunol 165:5970-9. 2000
    ..These results indicate that there are profound abnormalities in the various B cell compartments in SLE that respond differently to immunosuppressive therapy...
  28. pmc STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation
    SEAN A DIEHL
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 180:4805-15. 2008
    ..Thus, up-regulation of BLIMP1 alone is not sufficient for differentiation of primary human B cells into plasma cells; concomitant down-regulation of BCL6 is absolutely required for completion of the plasma cell differentiation program...
  29. ncbi Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model
    Hidefumi Hiramatsu
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Blood 102:873-80. 2003
    ..Immature B cells resided mainly in bone marrow (BM), whereas mature B cells with surface immunoglobulins were preferentially found in spleen. NK cells were identified in BM and spleen...
  30. ncbi Plasma cells: finding new light at the end of B cell development
    K L Calame
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Nat Immunol 2:1103-8. 2001
    ..This review will summarize our current understanding of the molecules that regulate commitment to a plasma cell fate and those that mediate plasma cell function...
  31. ncbi Clinical assessment of blood leukocytes, serum cytokines, and serum immunoglobulins as responses to sleep deprivation in laboratory rats
    Carol A Everson
    Medical College of Wisconsin, Veterans Affairs Medical Center, Neurology Research 151, 5000 West National Ave, Milwaukee WI 53295, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1054-63. 2005
    ....
  32. ncbi TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer
    M Kuramochi
    Tumor Suppression and Functional Genomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Nat Genet 27:427-30. 2001
    ..2. Thus, attenuation of TSLC1 expression occurred in 85% of primary tumors with LOH. Hypermethylation of the TSLC1 promoter would seem to represent the 'second hit' in NSCLC with LOH...
  33. pmc Perspectives on immunoglobulins in colostrum and milk
    Walter L Hurley
    Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Nutrients 3:442-74. 2011
    b>Immunoglobulins form an important component of the immunological activity found in milk and colostrum. They are central to the immunological link that occurs when the mother transfers passive immunity to the offspring...
  34. ncbi The tumor suppressor protein TSLC1 is involved in cell-cell adhesion
    Mari Masuda
    Tumor Suppression and Functional Genomics Project, National Cancer Center Research Institutes, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 277:31014-9. 2002
    ..Taken together, these results indicate that TSLC1 mediates intracellular adhesion through homophilic interactions in a Ca(2+)/Mg(2+)-independent manner...
  35. ncbi Repertoire of human natural anti-glycan immunoglobulins. Do we have auto-antibodies?
    Nicolai Bovin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russian Federation
    Biochim Biophys Acta 1820:1373-82. 2012
    ..Their epitope specificity did not vary between different healthy individuals. Nominally, all the mentioned immunoglobulins could be classified as auto-antibodies.
  36. pmc CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion
    Elena P Moiseeva
    Department of Infection, Immunity and Inflammation, Institute for Lung Health, Clinical Sciences Wing, Glenfield Hospital, University of Leicester, Leicester LE3 9QP, UK
    Cell Mol Life Sci 69:2751-64. 2012
    ..The most highly expressed SP4 isoform is likely to contribute to MC aggregation and longevity in mastocytosis, and augment the pathophysiology of allergic diseases...
  37. ncbi Overexpression of a cell adhesion molecule, TSLC1, as a possible molecular marker for acute-type adult T-cell leukemia
    Hidenori Sasaki
    Department of Biochemistry, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Blood 105:1204-13. 2005
    ..These results suggested that the ectopic expression of TSLC1 could provide a novel marker for acute-type ATL and may participate in tissue invasion, a characteristic feature of the malignant ATL cells...
  38. ncbi Neuronal RA175/SynCAM1 isoforms are processed by tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM17-like proteases
    Yuko Tanabe
    Division of Development and Differentiation, Department of Human Inherited Metabolic Disease, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi machi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 444:16-21. 2008
    ....
  39. pmc On the genomics of immunoglobulins in the gray, short-tailed opossum Monodelphis domestica
    Xinxin Wang
    Department of Biology, Center for Evolutionary and Theoretical Immunology, The University of New Mexico, Albuquerque, NM 87131, USA
    Immunogenetics 61:581-96. 2009
    ..domestica, the only non-eutherian mammalian species for which this has been accomplished, strengthening the utility of this species as a model organism...
  40. ncbi Defective B cell development and function in Btk-deficient mice
    W N Khan
    Howard Hughes Medical Institute, Childrens Hospital, Boston, Massachusetts 02115, USA
    Immunity 3:283-99. 1995
    ..These results prove that lack of Btk function results in an Xid phenotype and further suggest a differential requirement for Btk during the early stages of murine versus human B lymphocyte development...
  41. pmc Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients
    Mei Tian
    Key Laboratory of Ministry of Health for Biotech Drug, Key Laboratory for Modern Medicine and Technology of Shandong Province, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan 250062, PR China
    BMC Cancer 8:241. 2008
    ..Pancreatic juice is an ideal specimen for PDAC biomarkers discovery, because it is an exceptionally rich source of proteins released from pancreatic cancer cells...
  42. ncbi Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif
    L L Isom
    Department of Pharmacology, University of Washington Seattle 98195 7280, USA
    Cell 83:433-42. 1995
    ..They may be important regulators of sodium channel expression and localization in neurons...
  43. ncbi B cell heterogeneity in the teleost kidney: evidence for a maturation gradient from anterior to posterior kidney
    Patty Zwollo
    Department of Biology, The College of William and Mary, Virginia Institute of Marine Science, The College of William and Mary, 23185, USA
    J Immunol 174:6608-16. 2005
    ..Lastly, our data support the notion that the trout kidney is a complex, multifunctional immune organ with the potential to support both hemopoiesis as well as humoral immune activation...
  44. ncbi A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2
    H Gomyo
    Radiobiology Division, Oncogene Division, Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genomics 62:139-46. 1999
    ..The IGSF4 gene, a novel gene that is shown to be located in the common loss of heterozygosity region, possesses a number of interesting features and may be good candidate for a tumor suppressor gene...
  45. ncbi Longterm safety of patients receiving rituximab in rheumatoid arthritis clinical trials
    Ronald F van Vollenhoven
    Karolinska University Hospital, Stockholm, Sweden
    J Rheumatol 37:558-67. 2010
    ..To evaluate the longterm safety of rituximab in clinical trials in patients with rheumatoid arthritis (RA)...
  46. ncbi Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    P Waterhouse
    Department of Immunology, University of Toronto, Ontario, Canada
    Science 270:985-8. 1995
    ..Thus, CTLA-4 acts as a negative regulator of T cell activation and is vital for the control of lymphocyte homeostasis...
  47. ncbi The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM
    Kent S Boles
    Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Blood 106:779-86. 2005
    ..Furthermore, they reveal Necl-2 as one of the molecular targets that allows the immunosurveillance network to distinguish tumor cells from normal cells...
  48. ncbi Regulation of a late phase of T cell polarity and effector functions by Crtam
    Jung Hua Yeh
    Department of Immunology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Cell 132:846-59. 2008
    ..Crtam engagement thus modulates signals many hours beyond the initial activation event and dynamically influences the adaptive immune response...
  49. ncbi New insights into the diversity and function of neuronal immunoglobulin superfamily molecules
    Genevieve Rougon
    Laboratoire NMDA CNRS UMR 6156, Universite de la Mediterranee, Institut de Biologie du Developpement IBDM, Marseille Cedex 9, 13288 France
    Annu Rev Neurosci 26:207-38. 2003
    ..We illustrate that the complexity of IgSF protein function results from various different levels of regulation including regulation of gene expression, protein localization, and protein interactions...
  50. ncbi Dendrite branching and self-avoidance are controlled by Turtle, a conserved IgSF protein in Drosophila
    Hong Long
    Centre for Research in Neuroscience and Department of Neurology and Neurosurgery, McGill University, and the McGill University Health Centre Research Institute, QC, Canada
    Development 136:3475-84. 2009
    ....
  51. ncbi Extensive diversity of Ig-superfamily proteins in the immune system of insects
    Fiona L Watson
    Department of Cancer Biology, Dana Farber Cancer Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 309:1874-8. 2005
    ....
  52. ncbi The chicken leukocyte receptor cluster
    Birgit C Viertlboeck
    Institute of Animal Physiology, Department of Veterinary Sciences, LMU Munchen, Veterinarstr 13, 80539 Munchen, Germany
    Vet Immunol Immunopathol 144:1-10. 2011
    ..Detailed analyses of CHIR-AB1, its crystal structure, the interaction to IgY and functional capabilities allow us to draw conclusions regarding Fc receptor phylogeny and function...
  53. ncbi Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome
    M Kestila
    Department of Biochemistry, University of Oulu, Finland
    Mol Cell 1:575-82. 1998
    ..The results demonstrate a crucial role for this protein in the development or function of the kidney filtration barrier...
  54. ncbi The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance
    Anja Fuchs
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Semin Cancer Biol 16:359-66. 2006
    ..We here review current knowledge on these receptors, CD226, CD96 and CRTAM, and their role in tumor immunosurveillance...
  55. pmc The terminal immunoglobulin-like repeats of LigA and LigB of Leptospira enhance their binding to gelatin binding domain of fibronectin and host cells
    Yi Pin Lin
    Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 5:e11301. 2010
    ..This is the first report about the interaction of gelatin binding domain of Fn and Lig proteins and provides an example of Lig-gelatin binding domain binding mediating bacterial-host interaction...
  56. pmc NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily
    C Cantoni
    Istituto Nazionale per la Ricerca sul Cancro and Centro Biotecnologie Avanzate, 16132 Genova, Italy
    J Exp Med 189:787-96. 1999
    ..Unlike genes coding for other receptors involved in NK cell triggering or inhibition, the NKp44 gene is on human chromosome 6...
  57. pmc Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1
    Louise van der Weyden
    Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK
    Mol Cancer 11:29. 2012
    ..Inactivation of CADM1, either by promoter hypermethylation or loss of heterozygosity, has been reported in a wide variety of tumor types, thus it has been postulated as a tumor suppressor gene...
  58. ncbi Use of cytomegalovirus hyperimmunoglobulin for prevention of congenital cytomegalovirus disease: a retrospective analysis
    Horst Buxmann
    Department of Neonatology, University Hospital, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt Main, Germany
    J Perinat Med 40:439-46. 2012
    ....
  59. ncbi Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg
    Hiroshi Fukuhara
    Tumor Suppression and Functional Genomics Project, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 22:6160-5. 2003
    ..These results suggest that TSLC1 and MPP3 are involved in the same cascade of cell-cell interaction, and that the disruption of this cascade might lead cells to malignant growth and tumor formation in lung cancer...
  60. ncbi Visualization of the moment of mouse sperm-egg fusion and dynamic localization of IZUMO1
    Yuhkoh Satouh
    World Premier International Immunology Frontier Research Center, Osaka University, Yamadaoka 3 1, Suita, Osaka 565 0871, Japan
    J Cell Sci 125:4985-90. 2012
    ..Translocation of IZUMO1 during the fertilization process was clarified, and a fundamental mechanism in mammalian fertilization is postulated...
  61. ncbi Tumor suppressor CADM1 is involved in epithelial cell structure
    Mika Sakurai-Yageta
    Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 390:977-82. 2009
    ..These findings suggest that CADM1 is involved in the formation of epithelia-like cell structure with 4.1B and MPP2, while loss of its function could cause morphological transformation of cancer cells...
  62. pmc Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells
    Bernadette Pöllinger
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    J Exp Med 206:1303-16. 2009
    ..The secreted autoantibodies are pathogenic, enhancing demyelinating EAE episodes. RR mice constitute the first spontaneous animal model for the most common form of multiple sclerosis (MS), RR MS...
  63. ncbi Avian IgY antibodies and their recombinant equivalents in research, diagnostics and therapy
    Edzard Spillner
    Institute of Biochemistry and Molecular Biology, Department of Chemistry, University of Hamburg, Martin Luther King Platz 6, 20146 Hamburg, Germany
    Biologicals 40:313-22. 2012
    ..This review presents comprehensive information on the generation, purification, modification and applications of polyclonal and monoclonal IgY antibodies...
  64. ncbi Experimental evidence for direct in situ binding of IgM and IgT to early trophonts of Ichthyophthirius multifiliis (Fouquet) in the gills of rainbow trout, Oncorhynchus mykiss (Walbaum)
    L von Gersdorff Jørgensen
    Laboratory of Aquatic Pathobiology, Section of Biomedicine, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark
    J Fish Dis 34:749-55. 2011
    ..This study indicates that antibodies play an important part in the protection of immune fish against Ich although additional humoral and cellular factors may contribute to this reaction...
  65. pmc Teleost fish mount complex clonal IgM and IgT responses in spleen upon systemic viral infection
    Rosario Castro
    Virologie et Immunologie Moléculaires, INRA, Jouy en Josas, France
    PLoS Pathog 9:e1003098. 2013
    ..Thus, it appears that the general properties of antibody responses were already in place in common ancestors of fish and mammals, and were globally conserved during evolution with possible functional convergences...
  66. pmc Lateral assembly of the immunoglobulin protein SynCAM 1 controls its adhesive function and instructs synapse formation
    Adam I Fogel
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA
    EMBO J 30:4728-38. 2011
    ..These findings provide novel insights into synapse development and the adhesive mechanisms of Ig superfamily members...
  67. pmc Turtle functions downstream of Cut in differentially regulating class specific dendrite morphogenesis in Drosophila
    Mikolaj J Sulkowski
    School of Systems Biology, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 6:e22611. 2011
    ..Furthermore, the presence of numerous regulators suggests that they must work in concert. However, presently, few genetic pathways regulating dendrite development have been defined...
  68. ncbi A novel receptor involved in T-cell activation
    B G Cocks
    DNAX Research Institute of Molecular and Cellular Biology, Human Immunology Department, Palo Alto, California 94304 1104, USA
    Nature 376:260-3. 1995
    ..Thus SLAM is a novel receptor on T cells that, when engaged, potentiates T-cell expansion in a CD28-independent manner and induces a Th0/Th1 cytokine production profile...
  69. pmc A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis
    Harald F Langer
    Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 71:4096-105. 2011
    ..Together, JAM-C represents a novel therapeutic target for melanoma metastasis...
  70. ncbi Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth
    Chrystelle Lamagna
    Department of Pathology and Immunology, Centre Medical Universitaire, Geneva, Switzerland
    Cancer Res 65:5703-10. 2005
    ..Importantly, the antibody does not induce pathologic side effects in vivo. These findings show for the first time a role for JAM-C in angiogenesis and define JAM-C as a valuable target for antitumor therapies...
  71. pmc Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression
    Thomas E Sussan
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2185, USA
    Mol Cancer 4:28. 2005
    ..These results and the observation that TSLC1 is down-regulated in a number of tumors suggest that TSLC1 functions as a critical switch mediating repression of tumorigenesis...
  72. ncbi Expression of IgM, IgD, and IgY in a reptile, Anolis carolinensis
    Zhiguo Wei
    State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, Peoples Republic of China
    J Immunol 183:3858-64. 2009
    ..The absence of an IgA-encoding gene in the lizard IGH locus suggests a complex evolutionary history for IgA in the saurian lineage leading to modern birds, lizards, and their relatives...
  73. ncbi The immunoglobulin superfamily of neuronal cell adhesion molecules: lessons from animal models and correlation with human disease
    Markella Katidou
    University of Crete, Faculty of Medicine, Vassilika Vouton, Heraklion, Crete, Greece
    Biotechnol J 3:1564-80. 2008
    ..In this review, we concentrate on the NCAM, L1 and contactin subfamilies of neuronal IgCAMs summarizing recent functional studies from model systems and highlighting their links to disease pathogenesis...
  74. ncbi Adaptive immune response in JAM-C-deficient mice: normal initiation but reduced IgG memory
    Claudia Zimmerli
    Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland
    J Immunol 182:4728-36. 2009
    ..Taken together, these data suggest that JAM-C deficiency affects the adaptive humoral immune response against pathogens, in addition to the innate immune system...
  75. pmc Cell adhesion molecule 1: a novel risk factor for venous thrombosis
    Sandra J Hasstedt
    Department of Human Genetics, University of Utah, Salt Lake City, USA
    Blood 114:3084-91. 2009
    ..Finally, we have for the first time demonstrated CADM1 in endothelial cells, where it appears to be selectively involved in endothelial cell migration, suggesting a role in endothelial barrier repair...
  76. pmc Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system
    Kazuhiko Nishida
    Graduate School of Frontier Biosciences, Osaka University, Yamadaoka 1 3, Suita, Osaka 565 0871, Japan
    J Biol Chem 285:373-80. 2010
    ..We provided further evidence that Nephrin and Neph3 could interact homophilically and heterophilically, suggesting that Nephrin and Neph3 might regulate certain developmental aspects of Ptf1a-positive neurons as homo- or heterooligomers...
  77. pmc CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells
    Mari Masuda
    Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    J Biol Chem 285:15511-22. 2010
    ..Our results indicate that Tiam1 integrates signals from CADM1 to regulate the actin cytoskeleton through Rac activation, which may lead to tissue infiltration of leukemic cells in ATL patients...
  78. ncbi Production of brain-derived neurotrophic factor by mononuclear cells of patients with multiple sclerosis treated with glatiramer acetate, interferon-beta 1a, and high doses of immunoglobulins
    P Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia 06158, Italy
    Mult Scler 13:313-31. 2007
    ..sclerosis (MS) patients, who underwent treatment with glatiramer acetate (GA), interferon (IFN)-beta 1a, and immunoglobulins (Igs) (20 per treatment group), were assessed for levels of brain-derived neurotrophic factor (BDNF) in the ..
  79. ncbi Immunoglobulin dosage and switch from intravenous to subcutaneous immunoglobulin replacement therapy in patients with primary hypogammaglobulinemia: decreasing dosage does not alter serum IgG levels
    Sylvain Thepot
    Departement d Immunologie, Hopital Saint Louis, Assistance Publique Hopitaux de Paris, 1 avenue Claude Vellefaux, 75010 Paris, France
    J Clin Immunol 30:602-6. 2010
    ..The impact of reducing immunoglobulin dosage while switching from intravenous to subcutaneous replacement therapy was evaluated...
  80. ncbi Effects of parental effort on blood stress protein HSP60 and immunoglobulins in female blue tits: a brood size manipulation experiment
    Santiago Merino
    Departamento de Ecologia Evolutiva, Museo Nacional de Ciencias Naturales CSIC, Madrid, Spain
    J Anim Ecol 75:1147-53. 2006
    ..effort on changes in two types of proteins related with stress: the blood stress protein HSP60 and the plasma immunoglobulins. 2...
  81. ncbi Junctional Adhesion Molecules (JAMs) are differentially expressed in fibroblasts and co-localize with ZO-1 to adherens-like junctions
    Andrew P Morris
    Department of Integrative Biology and Pharmacology, University of Texas at Houston Medical School, Houston, Texas 77030, USA
    Cell Commun Adhes 13:233-47. 2006
    ..We conclude that endogenous JAM-C is an integral component of the dermal fibroblast adherens-like junction, and our data extend the expression and potential function of JAMs into mesenchymal tissues...
  82. ncbi Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women
    Renee M Overmeer
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 129:2218-25. 2011
    ..In conclusion, the methylation marker panel CADM1-M18 and MAL-M1 may serve as an alternative molecular triage tool for hrHPV-positive women...
  83. pmc Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules
    Heli Liu
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 286:797-805. 2011
    ..Our structures reveal a conserved homophilic adhesion mode for the L1 family and also shed light on how the pathological mutations of L1 affect its structure and function...
  84. ncbi A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP) part 1: immunization of infants, children, and adolescents
    Eric E Mast
    Division of Viral Hepatitis, National Center for Infectious Diseases, USA
    MMWR Recomm Rep 54:1-31. 2005
    ..The second part of the ACIP statement, which will include updated recommendations and strategies to increase hepatitis B vaccination of adults, will be published separately...
  85. ncbi The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues
    Sussan Nourshargh
    National Heart and Lung Institute, Imperial College London, UK
    J Leukoc Biol 80:714-8. 2006
    ..In vivo data with blocking antibodies or inactivation of JAM-A and PECAM genes indicate that the role of these two proteins depends on the stimulus and the experimental model used...
  86. ncbi Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
    Baohua Zhou
    Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA
    Nat Immunol 6:1047-53. 2005
    ..These findings suggest that TSLP is an important factor necessary and sufficient for the initiation of allergic airway inflammation...
  87. pmc IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF
    François Ehrenmann
    IMGT, the international ImMunoGeneTics information system, Universite Montpellier 2, Laboratoire d ImmunoGenetique Moleculaire LIGM, Institut de Genetique Humaine IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
    Nucleic Acids Res 38:D301-7. 2010
    ..IMGT/3Dstructure-DB contains 3D structures of immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility complex (MHC) proteins, antigen receptor/..
  88. ncbi Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins
    George F Widhopf
    UCSD School of Medicine, 9500 Gilman Dr, La Jolla, CA 9209, USA
    Blood 104:2499-504. 2004
    ..This finding provides compelling evidence that the Ig expressed by CLL B cells are highly selected and not representative of the Ig expressed by naive B cells...
  89. ncbi CD83 on dendritic cells: more than just a marker for maturation
    Matthias Lechmann
    Dept of Dermatology, University of Erlangen Nurnberg, Hartmannstrasse 14, D 91052, Erlangen, Germany
    Trends Immunol 23:273-5. 2002
    ..Recently, we have shown that the soluble extracellular CD83 domain inhibits DC-mediated T-cell proliferation, representing the first report describing a functional role for CD83...
  90. pmc Towards a molecular understanding of titin
    S Labeit
    European Molecular Biology Laboratory, Heidelberg, FRG
    EMBO J 11:1711-6. 1992
    ..We conclude that A-band titin is likely to be involved in the ordered assembly of the vertebrate thick filament...
  91. ncbi Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins
    L D Shultz
    J Immunol 116:936-43. 1976
    ..mutation motheaten (me) are deficient in capacity for immune response but show an elevated level of serum immunoglobulins. In comparison to spleen cells from normal sibs, spleen cells from me/me mice have a severely depressed 19S ..
  92. pmc Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly
    P Young
    European Molecular Biology Laboratory, Structural Biology Division, 69117 Heidelberg, Germany
    J Cell Biol 154:123-36. 2001
    ....
  93. ncbi Blood-cerebrospinal fluid barrier and intrathecal immunoglobulins compared to field diagnosis of central nervous system involvement in sleeping sickness
    S Bisser
    Institut d Epidémiologie Neurologique et de Neurologie Tropicale EA3174, Faculte de Medecine, 2 rue du Docteur Raymond Marcland, 87025 Limoges Cedex, France
    J Neurol Sci 193:127-35. 2002
    ..Improved criteria including B-CSFB dysfunction and IgM detection are needed in order to provide an adapted treatment regimen...
  94. pmc Detection of human Toxoplasma-specific immunoglobulins A, M, and G with a recombinant Toxoplasma gondii rop2 protein
    V Martin
    Departamento de Parasitologia, ANLIS Dr Carlos G Malbran, Buenos Aires, Argentina
    Clin Diagn Lab Immunol 5:627-31. 1998
    ..8% of group A sera and in 97.6% of the sera with acute-phase marker immunoglobulins (groups B, C, and D). The percentage of IgA antibody reactivity against Rop2196-561 was 17...
  95. ncbi Titins: giant proteins in charge of muscle ultrastructure and elasticity
    S Labeit
    European Molecular Biology Laboratory, Heidelberg, Germany
    Science 270:293-6. 1995
    ..This suggests that titin may act as two springs in series. The differential expression of the springs provides a molecular explanation for the diversity of sarcomere length and resting tension in vertebrate striated muscles...
  96. ncbi A critical role for IL-21 in regulating immunoglobulin production
    Katsutoshi Ozaki
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1674, USA
    Science 298:1630-4. 2002
    ..This suggests that these gammac-dependent cytokines may be those whose inactivation is primarily responsible for the B cell defect in humans with XSCID...
  97. pmc Kinetic analysis of L1 homophilic interaction: role of the first four immunoglobulin domains and implications on binding mechanism
    Ricardo M Gouveia
    Instituto de Tecnologia Quimica e Biologica, Avenida da República, Apartado 127, 2780 157 Oeiras, Portugal
    J Biol Chem 283:28038-47. 2008
    ..Furthermore, they are compatible with a cooperative interaction between modules Ig1-Ig4 in a horseshoe conformation...
  98. ncbi Immunoglobulins and complement in postmortem multiple sclerosis tissue
    Michael H Barnett
    Department of Medicine, Institute of Clinical Neurosciences, University of Sydney, New South Wales, Australia
    Ann Neurol 65:32-46. 2009
    ..evidence of a discrete, specific immune response in multiple sclerosis (MS) by analyzing the distribution of immunoglobulins and complement in tissue derived from cases of MS, and from control inflammatory white matter diseases known ..
  99. pmc A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms
    Michael R Sawaya
    Howard Hughes Medical Institute, UCLA DOE Institute of Genomics and Proteomics, Los Angeles, CA 90095, USA
    Cell 134:1007-18. 2008
    ..These studies provide insight into how "matching" at all three pairs of variable domains in Dscam mediates isoform-specific recognition...
  100. pmc Identification of IgF, a hinge-region-containing Ig class, and IgD in Xenopus tropicalis
    Yaofeng Zhao
    State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100094, People s Republic of China
    Proc Natl Acad Sci U S A 103:12087-92. 2006
    ..The IgH locus of X. tropicalis shows a 5' V(H)-D(H)-J(H)-C(mu)-C(delta)-C(chi)-C(upsilon)-C(phi) 3' organization, suggesting that the mammalian and amphibian Ig heavy-chain loci share a common ancestor...
  101. pmc SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning
    Elissa M Robbins
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Neuron 68:894-906. 2010
    ..The reciprocal effects of increased SynCAM 1 expression and loss reveal that this adhesion molecule contributes to the regulation of synapse number and plasticity, and impacts how neuronal networks undergo activity-dependent changes...

Research Grants79

  1. Importance of antigen specific immunoglobulin responses in controlling SIV/SHIV i
    Bapi Pahar; Fiscal Year: 2010
    ..Using this approach, we predict that we will be able to correlate SIV specific mucosal immune responses with reduction of viremia and protection from disease progression in macaques infected with pathogenic viruses. ..
  2. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..Understanding the pathogenesis of the reactive form of amyloidosis may reveal avenues for treatment of not only AA amyloidosis but also other forms of amyloidosis in the Veteran population. ..
  3. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    ....
  4. Vascular dysfunction and oxidative stress in primary amyloidosis
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2010
    ..The research will provide important information on the basis and possible treatment of primary systemic amyloidosis that may lead to improvement in survival in these patients. ..
  5. Non-coding RNA engineers antibody diversity
    Uttiya Basu; Fiscal Year: 2011
    ..Antibodies are polypeptide complexes produced from B-lymphocytes that are present in the bodily fluids of vertebrates, and are used by the immune system to identify and neutralize foreign antigens, such as bacteria and viruses. ..
  6. Antibody-mediated Gene Therapy for the Treatment of Cancer
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..The outstanding research environment at UCLA, the guidance from my experienced mentors, and this award will greatly facilitate my success in reaching my goals and will open a new dimension in my professional development. ..
  7. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ....
  8. Role of Endocytosis and Vesicular Trafficking in Podocyte Health and Filter Integ
    Puneet Garg; Fiscal Year: 2012
    ....
  9. Fic-mediated Adenylylation
    CAROLYN ANN WORBY; Fiscal Year: 2013
    ..This covalent addition of AMP blocks signal transduction pathways in the host that are important for combating bacterial infections. ..
  10. MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSE
    David R Brown; Fiscal Year: 2010
    ....
  11. Lysosomal phospholipase A2 in autoimmune disease
    JAMES ALAN SHAYMAN; Fiscal Year: 2013
    ..Understanding the mechanisms whereby impaired degradation of phospholipids result in the autoimmune phenotype may provide new insights into the pathogenesis of lupus and potential new targets for therapy. ..
  12. Regulation of the VDJ recombinase during genotoxic stress
    Karla K Rodgers; Fiscal Year: 2013
    ..The ability to enhance such a regulatory process may lead to decreased risks of developing lymphoid malignancies following exposure to radiation and other DNA damaging drugs. ..
  13. Microbial Diversity in Mechanisms of Disulfide Bond Formation and Reduction
    Dana Boyd; Fiscal Year: 2013
    ..large amounts of proteins that have disulfide bonds and are medically important such as peptide hormones and immunoglobulins. Also, since disulfide-bonded proteins are found in many of the most prominent bacterial virulence factors, ..
  14. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2012
    ....
  15. Targeting Siglec-8/-F to treat eosinophil and mast cell related disorders
    Bruce S Bochner; Fiscal Year: 2013
    ....
  16. Hypoplastic Left Heart Syndrome: Expression of RHD in the Fetus?
    Pirooz Eghtesady; Fiscal Year: 2013
    ..Tremendous resources are devoted to its medical management. Therefore, understanding why HLHS happens, the goal of the proposed research would have great significance and relevance to public health. ..
  17. IMMUNOLOGIC BASIS OF RESISTANCE AND HYPERSENSITIVITY
    KARL FRANK AUSTEN; Fiscal Year: 2012
    ..Characterization of these proinflammatory pathways allows for therapeutic approaches based on targeted intervention. ..
  18. High Throughput Screening of the Autoimmune Epitome
    Nancy J Olsen; Fiscal Year: 2010
    ..Using this as a model system, it is hoped that other autoimmune diseases will benefit from early diagnosis and treatment. ..
  19. A Fourth Outcome: DNA Damage and the Differentiation of B Cells
    Michael A Teitell; Fiscal Year: 2013
    ..Overall, we dissect a new and unexpected fourth outcome for DNA damage- cell differentiation. ..
  20. Antiviral prophylaxis to prevent perinatal transmission of HBV in Thailand
    GONZAGUE JOSEPH JOURDAIN; Fiscal Year: 2013
    ..An interim analysis will be conducted when half of the outcomes are available. The results of the study will help define policy to manage HBV infected pregnant women to prevent perinatal transmission. ..
  21. Protein Handling By Renal Proximal Tubule Epithelial Cells
    Nicholas Ferrell; Fiscal Year: 2013
    ..For Aim 2, we will investigate the affects of other high molecular weight proteins (transferrin and immunoglobulins) that enter the tubule in disease to evaluate if these proteins compete with albumin in the endocytic ..
  22. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Many vitally important proteins which are secreted (such as immunoglobulins and polypeptide hormones) or present at the cell surface (including cell adhesion molecules and signaling receptors) are ..
  23. Immunoglobulin Activation of Fibroblasts
    Terry J Smith; Fiscal Year: 2012
    ..In this proposal, we identify abnormalities in human immune system that underlie development of TAO, and apply these insights to animal models in which treatments can be developed. ..
  24. Novel Erythroid Cell Membrane Protein
    Emery H Bresnick; Fiscal Year: 2010
    ....
  25. NICHD INTERNATIONAL & DOMESTIC PEDIATRIC &MATERNAL HIV STUDIES COORDINATING CTR
    CAROL NESEL; Fiscal Year: 2013
    ..This repository serves as a resource for Network and external investigators who are interested in answering specific questions related to HIV/AIDS. ..
  26. Long-Range Genetic and Epigenetic Control of Igh Gene Assembly
    Eugene M Oltz; Fiscal Year: 2010
    ..We propose studies to address how precursor B cells control long-range changes in the spatial organization of the immunoglobulin heavy chain locus to ensure its proper assembly and pursuant generation of an adaptive immune system. ..
  27. Antibody Mediated Autoimmunity in Neuromyelitis Optica
    HANS CHRISTIAN VON BUEDINGEN; Fiscal Year: 2013
    ..recombinant monoclonal antibodies (rAbs) generated from CSF plasma cells, and by b.) purified soluble immunoglobulins from serum and CSF from anti- AQP4 seropositive NMO patients...
  28. Regulation of Immunoglobulin Class Switch in Aged Mice
    Bonnie B Blomberg; Fiscal Year: 2013
    ..Studies of protein and mRNA stability, post translational regulation, and signal transduction pathways including MAPK, will determine key molecular elements in the control of Ig class switch in aged mice. ..
  29. TREM-1 in Lung Immune Response
    Ruxana T Sadikot; Fiscal Year: 2013
    ..aeruginosa. ..
  30. Role of the developmental regulator Gon4-like in B lymphopoiesis
    JOHN D COLGAN; Fiscal Year: 2011
    ..Further, the knowledge gained will provide new insights regarding the fundamental processes that contribute to immune dysfunction or the development of lymphoid cancers. ..
  31. Nanoliposome-based Treatment of Amyloid Protein (AL) Toxicity
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2013
    ....
  32. Recombinant Antibodies from the Sea Lamprey
    ZEEV contact PANCER; Fiscal Year: 2010
    ..We propose to develop high affinity recombinant antibodies from the sea lamprey as a completely new class of recognition molecules for diagnostic, analytic, and biosensor applications in biotechnology. ..
  33. Origins of Diversity at Human Classical MHC Class I Genes
    PETER R PARHAM; Fiscal Year: 2013
    ..By studying these rapidly evolving immune system components in closely related species of non-human primate we will gain new insight and greater understanding of the human system and its contribution to human health and survival. ..
  34. Nogo Receptors as Therapeutic Targets in a Model of Multiple Sclerosis
    BENJAMIN MATTHEW SEGAL; Fiscal Year: 2013
    ..If successful, NgR antagonists will represent the first class of agents used to treat MS that have both anti-inflammatory and neuroprotective/ neurorestorative properties. ..
  35. Enhancement of Dendritic Cells After Burn Injury
    Tracy Toliver Kinsky; Fiscal Year: 2009
    ..These studies will determine rf enhancement of dendritic cells after severe bums can increase resistance to bum wound infection, and will determine the contribution of dendritic cells to specific immune functions. ..
  36. Improved idiotype immunotherapy for lymphoma by RNA vaccine delivery
    ALISON ANNE MCCORMICK; Fiscal Year: 2010
    ..Unlike current therapies, custom vaccines are easily made, and may facilitate widespread adoption of individualized patient immunotherapy. ..
  37. Molecular Mechanisms and Treatment of Primary Amyloid AL Cardiomyopathy
    Ronglih Liao; Fiscal Year: 2013
    ..This work represents our continued intensive investigation of the mechanism underlying amyloid cardiomyopathy. ..
  38. Accessibility Control of Antigen Receptor Gene Assembly
    Eugene M Oltz; Fiscal Year: 2013
    ..We propose studies to address how precursor T lymphocytes activate the T cell receptor beta locus at the earliest stages of thymocyte development to ensure its proper assembly by V(D)J recombination. ..
  39. Lymph Node Alterations in Cancer
    M ALANNA RUDDELL; Fiscal Year: 2013
    ..The contribution of B cell-derived immunoglobulins or other secreted components to TDLN lymphangiogenesis and metastasis will be tested by injection of serum ..
  40. Defining the interaction of FCRLA with immunoglobulin
    PETER DANIEL BURROWS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The intracellular assembly of immunoglobulins (Ig) in B lineage cells is essential for normal antibody responses and is stringently regulated at multiple levels by endoplasmic reticulum (ER) ..
  41. MOLECULAR BASIS OF IMMUNOGLOBULIN HEAVY CHAIN SWITCH
    JANET M STAVNEZER; Fiscal Year: 2013
    ..We will investigate what makes these other sites targets for AID, and for DNA break formation. Thus our studies will also shed light on the important question of how AID chooses its targets. ..
  42. Viral Gastroenteritis: Basis of Protection and Virulence
    HARRY BERNARD GREENBERG; Fiscal Year: 2013
    ..They also represent a highly tractable system to study basic aspects of innate, acquired and mucosal immunity and viral pathogenesis, all important issues for the future of infectious disease prevention and treatment. ..
  43. Role of ncRNA Surveillance Complex "RNA Exosome" in Class Switch Recombination an
    Uttiya Basu; Fiscal Year: 2013
    ..Understanding of AID function in B-lymphocytes will allow treatment of these patients with directed clinical therapies. ..
  44. Specific Contribution of a New IG Isotype (IGT) in Teleost Fish Immune Responses
    J Oriol Sunyer; Fiscal Year: 2013
    ..Therefore, a better knowledge of the fish immune system is essential to the development of new therapeutic agents and vaccines to prevent fish diseases. ..
  45. CRTC2 in Cellular Development, Function, and Neoplasia
    Michael A Teitell; Fiscal Year: 2013
    ..Overall, our studies expand the role for CRTC2 beyond metabolism and characterize an unexpected new regulator of B cell development and function. ..
  46. Human Population Diversity in Leukocyte Receptors
    PETER R PARHAM; Fiscal Year: 2013
    ..This project will determine the variability of these genes in the human population and how these differences affect their function. ..
  47. Immune Tolerance in Non-clonal Immune Systems
    David Nemazee; Fiscal Year: 2013
    ..The goal of this project is to determine how immune tolerance normally suppresses the generation of self reactive antibodies and to identify genes involved in the process. ..
  48. Lambda phage as a scaffold for influenza immunization
    Stephen Dewhurst; Fiscal Year: 2009
    ..copy number in a quasicrystalline array that facilitates antibody production through cross-linking of surface immunoglobulins. The central hypothesis of this proposal is that influenza A virus vaccine approaches can be improved, by ..
  49. Mechanisms of Immune Modulation by Probiotics
    Lijuan Yuan; Fiscal Year: 2012
    ....
  50. Regulation of CD4+ T cell responses by a progesterone receptor
    Grant Hughes; Fiscal Year: 2013
    ....
  51. Trefoil Factors Regulate Th2 Immunity
    DEBROSKI R HERBERT; Fiscal Year: 2013
    ..Successful completion of these aims will produce a better understanding of how Type 2 immunity is generated during parasite infection, which also bears relevance to therapies used to treat allergic disease. ..
  52. OUTER MEMBRANE PROTEINS OF PATHOGENIC LEPTOSPIRA SPECIES
    David A Haake; Fiscal Year: 2013
    ..We will develop outer membrane protein-based vaccines that prevent acquisition of renal infection by reservoir hosts and effectively block shedding of pathogenic leptospires. ..
  53. Influenza Immunity: Protective Mechanisms Against Pandemic Respiratory Virus
    MARK MORRIS DAVIS; Fiscal Year: 2013
    ..It will also provide important information regarding the mechanisms responsible for the generation of protective B cell immunity against a wide array of other important human pathogens and bioterrorism agents. ..
  54. Chemokines and Lymphoid Tissue Organization and Function
    Jason G Cyster; Fiscal Year: 2013
    ....
  55. EPIDEMIOLOGY OF HELICOBACTER PYLORI TRANSMISSION
    Julie Parsonnet; Fiscal Year: 2010
    ..pylori differ from person-to-person and from population-to-population, we hope this study will also expand the toolkit of immunoepidemiology for further studies in human populations. ..
  56. Diagnostic tools to link Bacteroides fragilis toxin isotypes and human disease
    Saraspadee Mootien; Fiscal Year: 2012
    ..The third is also an ELISA-based assay, which will detect immunoglobulins specific to individual BFT isotypes in human serum samples...
  57. Regulation of B Lymphocyte Defects in Senescent Humans
    Bonnie B Blomberg; Fiscal Year: 2013
    ....
  58. Aging Oxidative Stress and Microglia
    Paula C Bickford; Fiscal Year: 2013
    ..This will inform us as to critical pathways to target for the development of new interventions to improve cognitive aging. ..
  59. Tannerella forsythia intercations with host cells and other bacteria
    Ashu Sharma; Fiscal Year: 2012
    ..The studies proposed in this application are aimed at understanding the mechanisms of BspA-induced pathogenesis in periodontal disease and will be vital in developing therapeutic strategies against periodontal diseases in future. ..
  60. Validating a novel biomarker of clinical progression and survival in CLL
    Randall S Davis; Fiscal Year: 2013
    ....
  61. Modulation of Autoimmune Diabetes by N-acetyl-D-glucosamine Specific B cells
    BRIAN L DIZON; Fiscal Year: 2010
    ..Understanding the mechanisms involved in this link may provide insight on new strategies for earlier diagnosis, treatments, and prevention of T1D. ..
  62. Id3/B Lymphocytes and Atherosclerosis
    Coleen A McNamara; Fiscal Year: 2010
    ..built a team of leading experts in vascular disease, Id3, B cells and immunoglobulin production that uniquely positions us to make contributions toward understanding the mechanisms whereby B cells mediate atheroprotection ..
  63. Anti-Idiotype Therapy of Human B Cell Malignancy
    Ronald Levy; Fiscal Year: 2007
    ..Again, our eventual intention[unreadable] will be to design new clinical trials based on the enhanced potency of the vaccine maneuver provided DCs.[unreadable]..
  64. Immunoglobulin Somatic Mutation
    Ursula Storb; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page ............................................................................................................................................ 1 Description, ..
  65. Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
    Wayne G Shreffler; Fiscal Year: 2009
    ..Food allergy accounts for approximately 30,000 episodes of anaphylaxis and 100-200 deaths. This proposal is to study how allergen immunotherapy can protect people so that ultimately it can be more effective. ..
  66. AID in somatic mutation of immunoglobulin genes
    URSULA B STORB; Fiscal Year: 2010
    ..This process is beneficial, because it can result in highly specific and efficient antibodies against pathogens and cancer. However, it is also dangerous, because it can cause cancer of lymphocytes and autoimmunity. ..
  67. Immunoglobulin CDR-H3 and neutralizing antibodies to HIV
    Harry Schroeder; Fiscal Year: 2009
    ..In previous studies we have shown that immunoglobulins with hydrophobic CDR-H3s are normally culled from the conventional B cell repertoire...
  68. INTESTINAL & PLACENTAL FC-RECEPTORS FOR IMMUNOGLOBULIN
    Neil Simister; Fiscal Year: 2000
    ..Lastly, the proposed work almost completes the studies that follow directly from the discovery by the P.I. of MHC class I-related FcRs, and additional time will be essential to consider and plan future research directions. ..
  69. High-Throughput Low Cost Production of Chromatin-Immunoprecipitation-Grade Antib
    KEITH ELLIOTT KROPP; Fiscal Year: 2010
    ..coli, can serve as a low cost substitute for full length immunoglobulins in ChIP experiments...
  70. Analysis of Human B Cell Tolerance in Humanized Mice
    Roberta Pelanda; Fiscal Year: 2009
    ..These novel systems will also be amenable for testing novel potential therapeutics on patient cells. ..
  71. MEMBRANE RECEPTOR TRAFFICKING AND ANTIGEN PROCESSING
    Richard Mitchell; Fiscal Year: 1999
    ....
  72. IDIOTYPES AND IMMUNE COMPLEXES IN IGA NEPHROPATHIES
    Susan Jackson; Fiscal Year: 1993
    ..deposits) of IgA NP as well as determine the presence of disease- specific idiotypic markers of these immunoglobulins. We will also search for crossreactive idiotypes on IgA rheumatoid factors as well as study the possibility ..
  73. TISSUE SPECIFIC GENE EXPRESSION
    Huntington Potter; Fiscal Year: 1990
    ....
  74. Regulation of lung alveolar epithelial protein transport
    Kwang Jin Kim; Fiscal Year: 2005
    ..g., albumin (Alb) and immunoglobulins G (IgG)) are absorbed via saturable processes at rates greater than those predicted by passive diffusional ..
  75. EXPRESSION OF IMMUNOGLOBULIN GENES IN TRANSGENIC MICE
    Ursula Storb; Fiscal Year: 2000
    ..It is expected that these experiments will contribute to the understanding of the control of B cell development and Ig gene expression, and will provide new insights into immunological disorders with a B cell component. ..
  76. BC1-2 REARRANGEMENTS IN CLL
    Louise Showe; Fiscal Year: 1992
    ..These studies can help to define the molecular basis of the pathogenesis of CLL...
  77. IMMUNOGLOBULIN GENE TARGETING INTO THE MOUSE GERM LINE
    Matthias Wabl; Fiscal Year: 1992
    ..Mice with the deletion of Cdelta or the transcription termination site may reveal the function of IgD, and mice with an already arranged VDJ segment in the germ line will be tested for their antibody repertoire...
  78. CONTROL OF IMMUNOGLOBULIN SYNTHESIS
    Ursula Storb; Fiscal Year: 2001
    ..Understanding this mechanism will provide a fundamental basis for the unraveling of many diseases involving the immune system, such as autoimmunities, infectious diseases, allergies and cancer. ..
  79. Nanotechnology for One Step Concentration and Preservation of Labile Biomarkers i
    LANCE ALLEN LIOTTA; Fiscal Year: 2010
    ..in exceedingly low concentrations within complex mixtures of high-abundance proteins such as albumin and immunoglobulins. Moreover, biomarkers in the blood may be subjected to degradation during transportation and storage...