Genomes and Genes
eosinophil granule proteins
Summary: Proteins found in EOSINOPHIL granules. They are primarily basic proteins that play a role in host defense and the proinflammatory actions of activated eosinophils.
Publications181 found, 100 shown here
- The development of a sensitive and specific ELISA for mouse eosinophil peroxidase: assessment of eosinophil degranulation ex vivo and in models of human diseaseSergei I Ochkur
Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ 85259, United States
J Immunol Methods 375:138-47. 2012..The presence of extracellular eosinophil granule proteins in affected tissues is a well established and specific marker of eosinophil activation in both patients ..
- Antimicrobial activity of human eosinophil granule proteins: involvement in host defence against pathogensAnu Malik
Immunochemistry Laboratory, National Institute of Immunology, New Delhi, India
Crit Rev Microbiol 38:168-81. 2012..The four major eosinophil granule proteins, major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil derived neurotoxin (EDN) and ..
- In vitro killing of microfilariae of Brugia pahangi and Brugia malayi by eosinophil granule proteinsK J Hamann
Department of Immunology, Mayo Medical School, Rochester, MN 55905
J Immunol 144:3166-73. 1990..Here, we performed in vitro assays of the toxicity of four purified eosinophil granule proteins, namely, MBP, EPO, eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN), for the ..
- Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificityG J Swaminathan
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
J Biol Chem 276:26197-203. 2001..Our analysis suggests that EMBP specifically binds heparin. Based on our results, we propose a possible new function for this protein, which is likely to have implications for EMBP function...
- Differential extraction of eosinophil granule proteinsLyo E Ohnuki
Department of Dermatology, University of Utah, Salt Lake City, 84132, USA
J Immunol Methods 307:54-61. 2005..These results indicate that repetitive extraction of eosinophil granules yields an increased amount of all granule proteins, and that MBP2 can now be recovered in good quantities and in a relatively pure form...
- Serum eosinophil derived neurotoxin may reflect more strongly disease severity in childhood atopic dermatitis than eosinophil cationic proteinS Taniuchi
Department of Paediatrics, Kansai Medical University, Fumizonocho 10 15, Moriguchi, 570 8506, Osaka, Japan
J Dermatol Sci 26:79-82. 2001..The skin scores were more significantly correlated with serum EDN levels than ECP levels. We concluded that serum EDN may reflect more strongly disease severity as eosinophilic activation in AD children than serum ECP...
- Eosinophil granule proteins in peripheral blood granulocytesR I Abu-Ghazaleh
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905
J Leukoc Biol 52:611-8. 1992..5; EDN, 72 +/- 9; and ECP, 50 +/- 12. Therefore we conclude that these proteins are mainly expressed in eosinophils, but that certain ones are present in basophils and neutrophils...
- Polymorphism of the eosinophil cationic protein-gene is related to the expression of allergic symptomsU B Jönsson
Department of Medical Sciences and Asthma Research Centre, University of Uppsala, Uppsala, Sweden
Clin Exp Allergy 32:1092-5. 2002..This polymorphism would cause the change of the amino acid arginine (base at position 434 is G) at position 97 to threonine (base at position 434 is C)...
- Tissue eosinophilia in acute and chronic atopic dermatitis: a morphometric approach using quantitative image analysis of immunostainingP Kiehl
Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str 5, D 30449 Hannover, Germany
Br J Dermatol 145:720-9. 2001..The frequency and amount of tissue eosinophilia in spontaneous lesions of acute and chronic atopic dermatitis (AD) are still a matter of controversy, and little is known about the distribution of eosinophilia in skin...
- Two eosinophil granule proteins, eosinophil peroxidase and major basic protein, inhibit mucin release from hamster tracheal surface epithelial cells in primary cultureK C Kim
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore 21201, USA
Inflamm Res 48:314-7. 1999..Effects of eosinophil proteins on airway goblet cell mucin release were investigated using primary hamster tracheal surface epithelial (HTSE) cell cultures...
- Eosinophil granule proteins in the assessment of airway inflammation in pediatric bronchial asthmaO D Wolthers
Children s Clinic Randers, Randers, Denmark
Pediatr Allergy Immunol 14:248-54. 2003b>Eosinophil granule proteins such as eosinophil cationic protein (ECP), eosinophil peroxidase (EPO) and eosinophil protein X (EPX) in serum and urine are indirect measures of eosinophil activity...
- Interactions of eosinophil granule proteins with skin: limits of detection, persistence, and vasopermeabilizationMark D P Davis
Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA
J Allergy Clin Immunol 112:988-94. 2003b>Eosinophil granule proteins, including eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO), and major basic protein (MBP), are prominently deposited in skin in several cutaneous disorders ..
- Urine eosinophil protein X (EPX) is an in vitro parameter of inflammation in atopic dermatitis of the adult ageK Breuer
Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, D-30449 Hannover, Germany
Allergy 56:780-4. 2001..36, P<0.0001 and 0.34, P<0.0001, respectively). CONCLUSION: Urine EPX is a useful in vitro parameter of inflammation in atopic dermatitis of the adult age...
- Effects of human mast cell tryptase and eosinophil granule proteins on the kinetics of blood clottingMichael Samoszuk
Pathology Department, University of California Irvine, UCI Medical Building 10, Route 40, 101 The City Drive, Orange, CA 92868 3298, USA
Am J Hematol 73:18-25. 2003..b>Eosinophil granule proteins and purified eosinophil peroxidase markedly reduced the anticoagulant properties of the mast cell ..
- Neutrophil and eosinophil granule proteins as markers of response to local prednisolone treatment in distal ulcerative colitis and proctitisP Sangfelt
Department of Internal Medicine, University Hospital, Uppsala, Sweden
Am J Gastroenterol 96:1085-90. 2001..05) in the response group and often occurred before clinical improvement. There was a nonsignificant trend toward a decrease in the concentrations of ECP and EPO at the end of treatment in responders...
- Double-blind, randomized, placebo-controlled trial of effect of nedocromil sodium on clinical and inflammatory parameters of asthma in children allergic to dust miteI Stelmach
M. Curie Hospital, Department of Pediatrics and Allergy, Zgierz, Poland
Allergy 56:518-24. 2001..No correlation was found between any of the measured parameters. CONCLUSION: Nedocromil sodium provided effective anti-inflammatory treatment for children with moderate atopic asthma...
- Eosinophils and eosinophilic cationic protein in induced sputum and blood: effects of budesonide and terbutaline treatmentRuth E Aldridge
Canterbury Respiratory Research Unit, Christchurch School of Medicine, University of Otago, Christchurch Hospital, Christchurch, New Zealand
Ann Allergy Asthma Immunol 89:492-7. 2002..Eosinophilic cationic protein (ECP) levels in sputum and blood correlate with clinical severity, and serial measurements of ECP have been proposed as a suitable candidate...
- Identification and characterization of human eosinophil cationic protein by an epitope-specific antibodyE Boix
Departament de Bioquimica i Biologia Molecular, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
J Leukoc Biol 69:1027-35. 2001....
- Comparison of anti-inflammatory and clinical effects of beclomethasone dipropionate and salmeterol in moderate asthmaE Bacci
Cardiothoracic Dept, University of Pisa, Cisaneelo Hospital, Italy
Eur Respir J 20:66-72. 2002..Beclomethasone also had an overall greater clinical effect, although the improvement in symptoms and peak expiratory flow variability was similar after both treatments...
- Serum eosinophil cationic protein levels measured during exacerbation of asthma: characteristics of patients with low titresH Matsumoto
Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan
Clin Exp Allergy 31:637-43. 2001..Mechanisms other than eosinophilic inflammation, such as airway remodelling, may be involved in asthma exacerbation in these patients...
- Significance of the eosinophil cationic protein/eosinophil count ratio in asthmatic patients: its relationship to disease severityM Fujitaka
Department of Pediatrics, Hiroshima University School of Medicine, Japan
Ann Allergy Asthma Immunol 86:323-9. 2001..CONCLUSIONS: The ECP/Eo ratio may be useful in assessing asthma severity; however, the serum ECP concentration or peripheral blood eosinophil count is not useful...
- Eosinophil markers in blood, serum, and urine for monitoring the clinical course in childhood asthma: impact of budesonide treatment and withdrawalK Lönnkvist
Astrid Lindgren Children s Hospital, Stockholm and the Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Hospital, Stockholm
J Allergy Clin Immunol 107:812-7. 2001..Few studies have focused on the dynamics of airway inflammation as reflected by the activity of the eosinophils and their proteins after withdrawal of inhaled corticosteroids...
- Influence of different dosage schedules of inhaled fluticasone propionate on peripheral blood cytokine concentrations in childhood asthmaM J Visser
Department of Pulmonology, University Hospital Groningen, The Netherlands
Clin Exp Allergy 32:1497-503. 2002..Asthma is characterized by eosinophilic airways inflammation with elevated levels of IL-4, IL-5 and sICAM-1, and reduced levels of IL-10 and IFN-gamma. Inhaled corticosteroids powerfully reduce airways inflammation...
- Mild exacerbations and eosinophilic inflammation in patients with stable, well-controlled asthma after 1 year of follow-upJ Belda
Hospital de la Santa Creu i Sant Pau, Barcelona, Catalunya, Spain
Chest 119:1011-7. 2001..Eosinophilic inflammation expressed as eosinophil count and ECP is associated with higher risk of mild exacerbation...
- Effect of physical and chemical methods of homogenization on inflammatory mediators in sputum of asthma patientsE Grebski
Pulmonary Division, Department of Internal Medicine, University of Zurich, Switzerland
Chest 119:1521-5. 2001..CONCLUSIONS: The sputum processing by DTT caused a statistically significant fall in EPO and MPO concentrations but did not significantly influence the measured concentrations of ECP and EPX...
- Effect of suplatast tosilate on airway hyperresponsiveness and inflammation in asthma patientsM Yoshida
Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Higashiku, Fukuoka, Japan
J Asthma 39:545-52. 2002..These results strongly suggest that oral administration of suplatast tosilate suppresses airway hyperresponsiveness in asthma patients by reducing eosinophilic inflammation in the airways...
- [Effect of triamcinolone acetonide, montelukast, nedocromil sodium and formoterol on eosinophil blood counts, ECP serum levels and clinical progression of asthma in children]Iwona Stelmach
Samodzielny Oddział Kliniczny Interny Dzieciecej i Alergologii Instytutu Pediatrii Akademii Medycznej w Łodzi
Pol Merkur Lekarski 12:208-13. 2002..This study shows that triamcinolon, montelukast contribute to inhibition of allergic inflammation by decreasing eosinophil blood counts and ECP. The serum level of ECP seems to be a good clinical marker of monitoring the disease...
- Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patientsYasushi Obase
Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
Chest 121:143-50. 2002..Leukotrienes (LTs) are important in asthma, and LT modifiers modulate antigen-induced asthma. Overproduction of LT by suppression of cyclooxygenase activity is involved in patients with aspirin-intolerant asthma (AIA)...
- The inflammatory marker serum eosinophil cationic protein (ECP) compared with PEF as a tool to decide inhaled corticosteroid dose in asthmatic patientsO Lowhagen
Asthma and Allergy Research Group, Sahlgrenska University Hospital, Gothenburg, Sweden
Respir Med 96:95-101. 2002..Recommendations suggesting lung function tests in current guidelines may be difficult to translate into clinical practice, however, a combination of inflammatory markers, lung function and symptoms may still improve asthma control...
- Effect of budesonide on the perception of induced airway narrowing in subjects with asthmaCheryl M Salome
Institute of Respiratory Medicine, University of Sydney, Sydney, New South Wales, Australia
Am J Respir Crit Care Med 165:15-21. 2002..We conclude that treatment with budesonide enhances the perception of airway narrowing, but the effect is unrelated to budesonide dose, or to changes in circulating eosinophil markers...
- Measurement of airway inflammation in asthmaNicola Wilson
Department of Paediatrics, Royal Brompton and Harefield National Health Service Trust, London, United Kingdom
Curr Opin Pulm Med 8:25-32. 2002..However, application of these markers continues to further our understanding of the disease process and provides the potential for more appropriate, customized therapy...
- Down-regulated IL-5 receptor expression on peripheral blood eosinophils from budesonide-treated children with asthmaC Hellman
Department of Medicine, Division of Clinical Immunology and Allergy, Stockholm, Sweden
Allergy 57:323-8. 2002..The expression and function of cytokine receptors on peripheral blood eosinophils (PBE) from healthy and asthmatic children are poorly characterized...
- Effect of theophylline on airway inflammation in asthmaJ Yang
Wuhan University People's Hospital, Wuhan 430060, China
Acta Pharmacol Sin 22:475-80. 2001..01), too. CONCLUSION: These results indicated that low dose theophylline had inhibitory action on airway inflammation in asthma with noticeable improvement of the patients' symptoms and lung function...
- Smoking and airway inflammation in patients with mild asthmaG W Chalmers
Department of Respiratory Medicine, Western Infirmary, Glasgow, UK
Chest 120:1917-22. 2001....
- A randomized, double-blind trial of the effect of glucocorticoid, antileukotriene and beta-agonist treatment on IL-10 serum levels in children with asthmaI Stelmach
Department of Paediatrics and Allergy, The M Curie Hospital, 35 Parzeczewska Str 95 100 Zgierz, Poland
Clin Exp Allergy 32:264-9. 2002..Triamcinolone has anti-inflammatory properties and the anti-inflammatory effects of montelukast and formoterol have been discussed...
- Sputum induction: effect of nebulizer output and inhalation time on cell counts and fluid-phase measuresJ Belda
The Asthma Research Group, Department of Medicine and Nuclear Medicine, St Joseph' s Healthcare and McMaster University, Hamilton, Ontario, Canada
Clin Exp Allergy 31:1740-4. 2001..The results draw attention to the need to standardize the volume and time of nebulization to accurately interpret and compare results...
- Comparison of hydrofluoroalkane-beclomethasone dipropionate Autohaler with budesonide Turbuhaler in asthma controlH Worth
Medizinische Klinik I, , Germany
Respiration 68:517-26. 2001..36 for HFA-BDP and -4.88 for BUD TH (p < 0.01). CONCLUSIONS: HFA-BDP 800 microg x day(-1) provided control of moderate-to-severe asthma with efficacy and safety at least similar to BUD TH 1,600 microg x day(-1)...
- Sputum eosinophilia in Churg-Strauss syndromeH Meziane
Clinique des Maladies Respiratoires and INSERM U 454, Hospital Arnaud deVilleneuve, CHU Montpellier, France
Respir Med 95:799-801. 2001..Eosinophil percentage in sputum and the total number of eosinophils in peripheral blood were more predictive of exacerbations of CSS than sputum ECP...
- Airway neutrophil inflammation in nonasthmatic patients with food allergyBenoit Wallaert
Clinique des Maladies Respiratoires, Service de Pneumologie et Immuno Allergologie, hôpital A Calmette, CHRU Lille, 59037 Lille Cedex, France
Allergy 57:405-10. 2002..In order to explain this observation, we sought to examine the presence of a bronchial inflammation in induced sputum of nonasthmatic patients with FA...
- A comparison of clinical use of fluticasone propionate and beclomethasone dipropionate in pediatric asthmaB R Nong
Department of Pediatrics, Veteran General Hospital-Kaohsiung, No. 386, Ta-Chung 1st Road, Kaohsiung, Taiwan
Kaohsiung J Med Sci 17:302-11. 2001..In conclusion, native data indicated that the potency of 100 micrograms of FP was equal to that of 200 micrograms of BD and that few side effects were noted in FP group. It is recommended that this drug be introduced for clinical use...
- Increased CD69 expression on peripheral blood eosinophils after specific inhalation challengePatrizia Pignatti
Servizio Autonomo di Allergologia e Immunologia Clinica, Fondazione S Maugeri, IRCCS, Istituto Scientifico di Pavia, Centro Medico di Pavia, Loc Cravino, Via Ferrata 8, 27100 Pavia, Italy
Allergy 57:411-6. 2002....
- [The relationship between eosinophils, activated T lymphocyte, leukotreine and the exercise-induced asthma]Y Guo
Department of Respiratory Medicine, Beijing Hospital, Beijing 100730, China
Zhonghua Jie He He Hu Xi Za Zhi 24:360-4. 2001..CONCLUSIONS: Hyperventilation during exercise may not be the cause leading to EIA, neither did the activation of T lymphocytes, IL-4 and IL-5 gene expression nor ECP. Leukotriene may play an important role in the pathogenesis of EIA...
- Liposome-entrapped D. pteronyssinus vaccination in mild asthma patients: effect of 1-year double-blind, placebo-controlled trial on inflammation, bronchial hyperresponsiveness and immediate and late bronchial responses to the allergenM J Alvarez
Department of Allergy, Hospital Virgen del Camino, Pamplona, Spain
Clin Exp Allergy 32:1574-82. 2002..Allergen vaccination is effective in mite-allergic asthma. Liposomes are immunological adjuvants that can act as allergen carriers...
- Acupuncture and bronchial asthma: a long-term randomized study of the effects of real versus sham acupuncture compared to controls in patients with bronchial asthmaTullio C Medici
Department of Internal Medicine, University Hospital Zurich, Switzerland
J Altern Complement Med 8:737-50; discussion 751-4. 2002..Although there are many published studies on acupuncture and asthma, few meet the scientific criteria necessary to prove the effectiveness of acupuncture...
- Assessment of inhaled BDP-dose dependency of exhaled nitric oxide and local and serum eosinophilic markers in steroids-naive nonatopic asthmaticsR Dal Negro
Lung Department, Hospital of Bussolengo, Verona, Italy
Allergy 58:1018-22. 2003....
- [Pathophysiology of airway hyperresponsiveness, the importance of early intervention in the treatment of asthma]Terufumi Shimoda
Nihon Kokyuki Gakkai Zasshi 41:606-10. 2003
- Absence of association of peripheral blood eosinophilia or increased eosinophil cationic protein with bronchial hyperresponsiveness during asthma remissionYoung Yull Koh
Department of Pediatrics and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
Ann Allergy Asthma Immunol 91:297-302. 2003..The mechanisms responsible for persistent bronchial hyperresponsiveness (BHR) in adolescents with long-term asthma remission are poorly understood...
- Increased prostaglandin E2 concentrations and cyclooxygenase-2 expression in asthmatic subjects with sputum eosinophiliaMirella Profita
Institute of Lung Pathophysiology, Italian National Research Council, Palermo, Italy
J Allergy Clin Immunol 112:709-16. 2003..Recently it has been reported that PGE2 can enhance eosinophil survival in vitro...
- [Clinical effects of long-term administration of pranlukast, a leukotriene receptor antagonist, on adult patients with bronchial asthma]Takahiko Horiguchi
Department of Internal Medicine, Fujita Health University Second Hospital, 3 6 10 Otobashi, Nakagawa Ku, Nagoya, 454 8509, Japan
Nihon Kokyuki Gakkai Zasshi 41:696-703. 2003..One year after medication was suspended, Group III showed a significant increase in the number of night visits to a medical facility and a rise in the serum ECP level. These findings indicated the efficacy of pranlukast...
- Efficacy of a short course of parent-initiated oral prednisolone for viral wheeze in children aged 1-5 years: randomised controlled trialAbraham Oommen
Leicester Children s Asthma Centre, Institute for Lung Health, University of Leicester, Leicester, UK
Lancet 362:1433-8. 2003..However, evidence for this treatment strategy is conflicting. We therefore aimed to assess the efficacy of a short course of oral prednisolone for preschool viral wheeze, with stratification for systemic eosinophil priming...
- Effect of inhaled beclomethasone dipropionate on peroxynitrite inhibitory activity in induced sputum from asthmatic patientsHiroshi Kanazawa
Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
Chest 124:1755-61. 2003..Therefore, this study was designed to examine the effect of inhaled beclomethasone dipropionate (BDP) on peroxynitrite inhibitory activity in induced sputum from asthmatic patients...
- Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in childrenRobert C Strunk
Washington University School of Medicine, St Louis, MO, USA
J Allergy Clin Immunol 112:883-92. 2003..Insufficient information is available concerning correlations between eNO and biologic, physiologic, and clinical characteristics of asthma in children currently not taking controller medications...
- [The effect of suplatast tosilate on the patients with atopic dermatitis--relationship between clinical symptoms and immunological parameters]Naoyuki Higashi
Department of Dermatology, Nippon Medical School
Arerugi 52:1065-73. 2003..7) There was no sign of adverse effects of the drug. From the above mentioned results, we confirmed the high efficacy of suplatast tosilate in the treatment of atopic dermatitis...
- [Effects of interleukin-1 receptor antagonist on the apoptosis of eosinophil in guinea pig with asthma]Feng Xu
Medical and Pharmacological, Institute of Yangzhou University, Yangzhou 225001, China
Yao Xue Xue Bao 38:661-4. 2003..To evaluate the effect of interleukin-1 receptor antagonist(IL-1ra) on apoptosis and associated mechanism of eosinophil in guinea pig with asthma...
- Effect of nasal triamcinolone acetonide on seasonal variations of bronchial hyperresponsiveness and bronchial inflammation in nonasthmatic children with seasonal allergic rhinitisFazil Orhan
Faculty of Medicine, Department of Pediatric Allergy, Hacettepe University, Ankara, Turkey
Ann Allergy Asthma Immunol 92:438-45. 2004..Recent evidence suggests that patients with allergic rhinitis have lower airway inflammation and a higher prevalence of bronchial hyperresponsiveness (BHR) regardless of asthma...
- Clinical evaluation of a transdermal therapeutic system of the beta2-agonist tulobuterol in patients with mild or moderate persistent bronchial asthmaTakahiko Horiguchi
Department of Internal Medicine, Fujita Health University Second Hospital, Nagoya, Aichi, Japan
Arzneimittelforschung 54:280-5. 2004....
- The ECP/Eo count ratio in children with asthmaIwona Stelmach
Department of Pediatrics and Allergy, M Curie Hospital, Zgierz, Poland
J Asthma 41:539-46. 2004..84; 95% CI: 1.02-3.34) a risk of moderate asthma. These data show that the ECP/Eo ratio is a better and more useful marker than ECP or peripheral blood eosinophil count separately in assessing asthma in children...
- Nitric oxide metabolites, eosinophils, and eosinophilic cationic protein in patients with asthma: sputum versus bloodAn Soo Jang
Department of Internal Medicine, Cheju National University College of Medicine, Jeju, Korea
J Korean Med Sci 18:489-93. 2003..These findings suggest that the proportion of eosinophils in sputum have more accurate diagnostic marker of asthmatic airway inflammation than NO metabolites in sputum in differentiating asthmatic patients from control subjects...
- [The influence oc glycocorticoid therapy on sputum ECP concentration in symptomatic patients with bronchial asthma]Joanna Hermanowicz-Salamon
Klinika i Katedra Chorób Wewnetrznych, Pneumonologii i Alergologii Akademii Medycznej w Warszawie
Pneumonol Alergol Pol 70:527-35. 2002..7 +/- 9.4 mcg/L, higher than in controls 12 +/- 5.8 mcg/L (p = 0.04). There were a significant correlations between total eosinophil count and serum (r = 0.6396) and sputum ECP(r = 0.4683) in exacerbation...
- High eosinophil cationic protein level in asthmatic patients with "heat" ZhengChing Hsaing Hsu
Department of Pediatric, China Medical College Hospital, Taichung, Taiwan
Am J Chin Med 31:277-83. 2003..Therefore, we conclude that ECP in asthmatic patients plays an important role in the development of "heat" manifestations as diagnosed by TCM...
- Antigen-specific IgE and IgA antibodies in bronchoalveolar lavage fluid are associated with stronger antigen-induced late phase reactionsR S Peebles
Divisions of Clinical Immunology and Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
Clin Exp Allergy 31:239-48. 2001..The results of this study point towards the possibility that allergen-specific IgE and IgA may be independently involved in the pathogenesis of the late phase reaction. This notion merits further exploration...
- Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthmaF Marcucci
Institute of Pediatrics, University of Perugia, Italy
Allergy 56:231-6. 2001..CONCLUSIONS: Both specific IgE and ECP in the nasal mucosa showed a better correlation with allergen exposure than serum evaluations. With an appropriate method, allergic inflammation may be best monitored in the nasal mucosa...
- Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndromeHans Uwe Simon
Department of Pharmacology, University of Bern, Bern, Switzerland
Eur J Immunol 33:834-9. 2003..These data suggest that patients with increased eosinophil surface CD25 expression are at higher risk of eosinophil degranulation and subsequent tissue damage when IL-2 is present at inflammatory sites...
- Eosinophils and eosinophil products in asthmaWaseem Saeed
Department of Pulmonology, Military Hospital, Pakistan
J Ayub Med Coll Abbottabad 14:49-55. 2002..Eosinophil-mediated damage to the respiratory epithelium is a major pathogenetic mechanism in asthma. This article is a review of the latest works about the relationship of eosinophil and eosinophil products with asthma...
- The relationship between inflammation and dipalmitoyl phosphatidycholine in induced sputum of children with asthmaAnne B Chang
Flinders University Northern Territory Clinical School, Alice Springs Hospital, Northern Territory, Australia
J Asthma 40:63-70. 2003..In this study we hypothesized that the degree of inflammation influences the level of dipalmitoyl phosphatidycholine (DPPC) in airways of children with asthma...
- Surplus value of eosinophil count and ECP to diagnose and monitor asthmatic patientsC J Pronk-Admiraal
Laboratory of Clinical Chemistry, Haematology and Immunology Medical Centre, Postbus 501 1800 AM Alkmaar, The Netherlands
Neth J Med 58:9-17. 2001..The additional value of serum ECP concentrations and eosinophil counts to detect an asthmatic constitution for individual cases is doubtful...
- Macrophage migration inhibitory factor (MIF) in bronchial asthmaE Yamaguchi
The First Department of Medicine, School of Medicine, Hokkaido University, Japan
Clin Exp Allergy 30:1244-9. 2000..Airways inflammation is a central feature of bronchial asthma and is characterized by the accumulation of eosinophils...
- Effects of low dose fluticasone/salmeterol combination on surrogate inflammatory markers in moderate persistent asthmaG P Currie
Asthma and Allergy Research Group Department of Pathology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
Allergy 58:602-7. 2003..We wished to examine the effects of low dose fluticasone/salmeterol combination on different commonly used inflammatory markers in moderate persistent asthma...
- A randomized controlled trial on the effect of montelukast on sputum eosinophil cationic protein in children with corticosteroid-dependent asthmaElke Strauch
Mathildenstrabetae 1, D 79106 Freiburg, Germany
Pediatr Res 54:198-203. 2003..05), or eosinophil count (p > 0.05) was found. In conclusion, add-on treatment with montelukast can suppress sputum ECP in children with steroid-dependent asthma, while at the same time an improvement in quality of life items occurs...
- Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthmaRonina A Covar
Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology and the Division of Allergy Clinical Immunology, Department of Pediatrics, Denver, Colorado, USA
J Pediatr 142:469-75. 2003..Exhaled nitric oxide (FE(NO)) was evaluated in children with asthma after 4 to 6 years of treatment with budesonide, nedocromil, or albuterol as needed...
- The effect of seratrodast on eosinophil cationic protein and symptoms in asthmaticsToshihiko Fukuoka
The Pulmonary Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
J Asthma 40:257-64. 2003..Seratrodast may be useful as an anti-inflammatory agent and beneficial when added to inhaled corticosteroids in the treatment of bronchial asthma...
- Roles of genotypes of beta2-adrenergic receptor in the relationship between eosinophil counts and lung function in Taiwanese adolescentsYing Chu Lin
Graduate Institute of Environmental and Occupational Health, National Cheng Kung University, College of Medicine, Tainan, Taiwan
J Asthma 40:265-72. 2003..The association between an increase of EOS and lower lung function can be differentiated by beta2AR genotypes at amino acid 16...
- Circulating fibrosis markers, eosinophil cationic protein and eosinophil protein X in patients with Wuchereria bancrofti infection: association with clinical statusP Esterre
Immunology Unit, Institut de Recherches Medicales Malarde, Papeete, Tahiti, French Polynesia
Parasite 13:165-70. 2006..of several circulating fibrosis markers (type I collagen I, type III procollagen, hyaluronan) and eosinophil granule proteins (ECP and EPX) in lymphatic filariosis patients to investigate their relationship with clinical, ..
- Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophilsF Levi-Schaffer
Department of Allergy and Clinical Immunology, Royal Brompton Hospital, London, UK
Blood 85:2579-86. 1995..Dot blot analysis with specific monoclonal antibodies (MoAbs) was used to detect the eosinophil granule proteins major basic protein (MBP) and eosinophil cationic protein (ECP)...
- Serum eosinophil granule proteins predict asthma risk in allergic rhinitisL P Nielsen
Departments of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark
Allergy 64:733-7. 2009..It is important to characterize these patients, thereby offering the possibility for prevention. This study evaluated eosinophil parameters as potential indicators of deteriorating allergic airway disease...
- Vesicle-mediated secretion of human eosinophil granule-derived major basic proteinRossana C N Melo
Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
Lab Invest 89:769-81. 2009..of inflammation noted losses of granule cores in the absence of granule exocytosis and suggested that eosinophil granule proteins might be released through piecemeal degranulation (PMD), a secretory process mediated by transport ..
- Eosinophils alter colonic epithelial barrier function: role for major basic proteinGlenn T Furuta
Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Boston, MA 02115, USA
Am J Physiol Gastrointest Liver Physiol 289:G890-7. 2005..In conclusion, MBP decreases epithelial barrier function and in this manner contributes to the pathogenesis of inflammatory bowel diseases...
- Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamilyK J Hamann
Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905
Genomics 7:535-46. 1990Human genomic DNAs for the eosinophil granule proteins, eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP), were isolated from genomic libraries...
- High vascular endothelial growth factor levels in NZW mice do not correlate with collagen deposition in allergic asthmaLuciana M C Vasquez-Pinto
Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
Int Arch Allergy Immunol 142:19-27. 2007..Eosinophil peroxidase (EPO) is one of the eosinophil granule proteins involved in the early response, but its participation in airway remodeling is not established...
- Inflammation and cell-cell interactions in airway hyperresponsivenessA R Leff
Department of Medicine, University of Chicago, Illinois 60637
Am J Physiol 260:L189-206. 1991..The molecular biology of the eosinophil granule proteins has characterized four distinct substances, each of which exerts potential cytotoxic effects on airway ..
- Evidence for eosinophil degranulation in acute appendicitisG Santosh
Department of Pathology, Medical College, Calicut 673 008, Kerala, India
Indian J Pathol Microbiol 51:172-4. 2008..This study aimed to measure the eosinophil degranulation resulting in a rise in the serum of eosinophil granule proteins that would be expected in such cases...
- Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cellsKim Doan Katrina Nguyen
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, SUNY Downstate Medical Center, Brooklyn, NY, USA
J Pediatr Gastroenterol Nutr 51:556-62. 2010..Eosinophilic esophagitis mimics GERD, but eosinophil granule proteins, known to mediate inflammation, have not been linked to BE...
- Eosinophil infiltration and degranulation in oesophageal mucosa from adult patients with eosinophilic oesophagitis: a retrospective and comparative study on pathological biopsyS Mueller
Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany
J Clin Pathol 59:1175-80. 2006..To examine eosinophil infiltration and degranulation in 50 oesophageal biopsy specimens from 30 patients (21 men, 9 women; mean 39 years) with eosinophilic oesophagitis, by haematoxylin and eosin staining and immunohistochemistry...
- Eosinophil granule proteins and their role in diseaseG M Walsh
Department of Medicine and Therapeutics, University of Aberdeen Medical School, Foresterhill, UK
Curr Opin Hematol 8:28-33. 2001..This review will update recent developments in understanding the role that eosinophil granule proteins play in human disease, particularly those of the respiratory tract.
- CD48 is an allergen and IL-3-induced activation molecule on eosinophilsAriel Munitz
Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
J Immunol 177:77-83. 2006..Furthermore, cross-linking CD48 on human eosinophils triggers release of eosinophil granule proteins. Assessment of CD48 expression in a murine model of experimental asthma revealed that CD48 is induced ..
- Eosinophil granules function extracellularly as receptor-mediated secretory organellesJosiane S Neves
Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:18478-83. 2008..ligand-responsive, secretion-competent structures constitute a novel postcytolytic mechanism for regulated secretion of eosinophil granule proteins that may contribute to eosinophil-mediated inflammation and immunomodulation.
- Eosinophil degranulation status in allergic rhinitis: observations before and during seasonal allergen exposureC A Ahlstrom-Emanuelsson
Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, 221 84 Lund, Sweden
Eur Respir J 24:750-7. 2004..In association with the development of symptomatic seasonal allergic rhinitis, the tissue deposition of eosinophil granule proteins is dramatically elevated through increased eosinophil numbers, together with markedly augmented ..
- Interleukin-16 expression and release in bullous pemphigoidA Frezzolini
Laboratory of Immunology and Allergology, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
Clin Exp Immunol 137:595-600. 2004....
- Longitudinal case analysis in atopic dermatitisP Helmbold
Department of Dermatology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
Acta Derm Venereol 80:348-52. 2000..In conclusion, longitudinal time-series analysis might represent an interesting and adequate method to generate and test new hypotheses on biomedical problems which cannot be addressed by cross-sectional studies...
- [Eosinophil cationic protein in serum of children with food allergy]Elzbieta Maciorkowska
III Klinika Chorob Dzieci, Akademii Medycznej w Białymstoku
Pol Merkur Lekarski 14:13-6. 2003..The studies indicate that the exclusive evaluation of ECP concentration in serum does not reflect unequivocally the severity of pathological changes of gastric mucosa in children with food allergy...
- Crystal structure of eosinophil cationic protein at 2.4 A resolutionE Boix
Department of Biology and Biochemistry, University of Bath, UK
Biochemistry 38:16794-801. 1999..The structure also shows how the cationic residues are distributed on the surface of the ECP molecule that may have implications for an understanding of the cytotoxicity of this enzyme...
- Clinical assessment of asthma severity partially corresponds to sputum eosinophilic airway inflammationM L Bartoli
Cardiothoracic Department, Respiratory Pathophysiology, Ospedale di Cisanello, University of Pisa, Via Paradisa 2, Pisa 56124, Italy
Respir Med 98:184-93. 2004..In conclusion, the assessment of asthma severity according to clinical and functional findings only partially corresponds to the severity of eosinophilic airway inflammation as assessed by induced sputum analysis...
- Inflammation markers and symptom activity in children with bronchial asthma. Influence of atopy and eczemaK H Carlsen
Voksentoppen Center of Asthma, Allergy and Chronic Lung Diseases in Children, Oslo, Norway
Pediatr Allergy Immunol 8:112-20. 1997..However, the relative impact of asthma symptoms and atopic eczema upon serum (s)-ECP in asthmatic children has not been established...
- The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthmaGail M Gauvreau
Department of Medicine, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
J Allergy Clin Immunol 112:331-8. 2003..Blocking of LFA-1/intercellular adhesion molecule interactions could inhibit asthmatic inflammation by blocking adhesion and activation of LFA-1-positive leukocytes...
- Nasal patency and biomarkers in nasal lavage--the significance of air exchange rate and type of ventilation in schoolsR Wålinder
Department of Occupational and Environmental Medicine, Uppsala University Hospital, Sweden
Int Arch Occup Environ Health 71:479-86. 1998..The aim of the present study was to examine the relationships between the ventilation rate and the type of ventilation system, on the one hand, and objective nasal measures, on the other...
- Ratio of eosinophil cationic protein/eosinophil count as a new marker in children with acute asthmaC Imai
Department of Pediatrics, Niigata University School of Medicine, Japan
Pediatr Int 41:142-6. 1999..It is a matter of concern whether serum eosinophil cationic protein (ECP) can be considered as a disease marker in children with acute asthma being treated without corticosteroids...
- CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gammaT Jinquan
Laboratory of Medical Allergology, Allergy Unit, National University Hospital, University of Copenhagen, Copenhagen, Denmark
J Immunol 165:1548-56. 2000....
- Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokinesP Romagnani
Department of Physiopathology, Section of Clinical Immunology, University of Florence, Florence, Italy
Am J Pathol 155:1195-204. 1999..Our findings indicate that these chemokines may play an important role in the differentiation and/or migration of this mast cell subset in connective tissues, as well as in sites of allergic inflammation...
- Serum levels of eosinophilic cationic protein (ECP), myeloperoxidase (MPO), lipid peroxidation products, interleukin (IL)-5 and interferon (IFN)-gamma in children with bronchial asthma at acute asthma attack and remissionO Kalayci
Hacettepe University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey
Turk J Pediatr 42:9-16. 2000..Serum IL-5 and IFN-gamma levels are not appropriate for use in the follow-up of asthmatic children...
- Matrix metalloproteinase-9, its tissue inhibitor(TIMP)-1 and CRP in Alzheimer's diseaseMichael Inspector
Neuroimmunology Unit, Carmel Medical Center, Haifa, Israel
Eur Neurol 53:155-7. 2005
- Urinary eosinophil protein X in children with asthma: influence of atopy and airway infectionsK Oymar
Department of Pediatrics, Rogaland Central Hospital, Stavanger, Norway
Pediatr Allergy Immunol 12:34-41. 2001....
- Eosinophil Granule Proteins and Their FunctionsGerald Gleich; Fiscal Year: 2006..Under the auspices of this grant, we have investigated the structure and function of eosinophil granule proteins, including major basic protein (MBP1), eosinophil-derived neurotoxin (EDN), eosinophil cationic protein ..
- Role of Spi-C in eosinophil development and functional responsesPATRICIA CHANDHOK FULKERSON; Fiscal Year: 2013..differentiation, survival and effector function via regulation of IL-5Ra expression and expression of eosinophil granule proteins. Defining the molecular regulators of eosinophil function and IL-5 responsiveness will undoubtedly ..
- Mouse Models of Eosinophil-Associated Lung DysfunctionNancy A Lee; Fiscal Year: 2013..define the pulmonary remodeling events, including induced lung dysfunction, mediated by the release of eosinophil granule proteins. PUBLIC HEALTH RELEVANCE: The scientific literature abounds with studies which question whether the ..
- Novel minimally invasive assessment of gastrointestinal inflammation in food alleGlenn Furuta; Fiscal Year: 2009..using the EST, performing measurements of specific eosinophil-expressed inflammatory mediators (eosinophil granule proteins), to determine their associations with the histopathologic features of EE disease...
- CARDIOTOXICITY OF EOSINOPHIL GRANULE CATIONIC PROTEINSHelene Rosenberg; Fiscal Year: 1991..to identify functionally significant amino acid sequences and to clarify the mechanisms by which the eosinophil granule proteins interact with their cardiovascular targets...
- EOSINOPHIL LEUKOCYTES AND ATOPIC DERMATITISKRISTIN LEIFERMAN; Fiscal Year: 1993..Second, because high concentrations of toxic eosinophil granule proteins are deposited in the skin, the effects of granule proteins on epithelium and mast cells will be ..
- Global Gene Expression in Chronic RhinosinusitisDOUGLAS PLAGER; Fiscal Year: 2005..These new molecular approaches should shed light on the mechanisms of CRS and open novel avenues for diagnosis and treatment of this difficult disease. ..
- Mechanisms of Eosinophilic Inflammation in Human AsthmaHirohito Kita; Fiscal Year: 2005..abstract_text> ..
- Planning a Multicenter Oral Itraconazole Trial in Chronic Rhinosinusitis PatientsHirohito Kita; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- MECHANISMS OF EOSINOPHIL DEGRANULATION IN HUMAN DISEASEHirohito Kita; Fiscal Year: 2010..Relevance: Patients with asthma have persistent respiratory problems. This research will investigate how the interaction of immune cells and our environment cause and worsen the disease. ..
- Neutrophils and HIV-1 infectionLarry Thomas; Fiscal Year: 2006..It is predicted that the results of this study will provide a basis for expanded and detailed analysis for potential and previously unrecognized involvement of neutrophils in HIV-1 transmission and disease. ..
- HIV and Neutrophil Function in Oral DiseaseLarry Thomas; Fiscal Year: 2003..As such, the results may provide an additional target to enhance innate immunity within the oral cavity and also to decrease the vertical transmission of HIV in breast milk. ..