eosinophil granule proteins

Summary

Summary: Proteins found in EOSINOPHIL granules. They are primarily basic proteins that play a role in host defense and the proinflammatory actions of activated eosinophils.

Top Publications

  1. pmc The development of a sensitive and specific ELISA for mouse eosinophil peroxidase: assessment of eosinophil degranulation ex vivo and in models of human disease
    Sergei I Ochkur
    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ 85259, United States
    J Immunol Methods 375:138-47. 2012
  2. ncbi Antimicrobial activity of human eosinophil granule proteins: involvement in host defence against pathogens
    Anu Malik
    Immunochemistry Laboratory, National Institute of Immunology, New Delhi, India
    Crit Rev Microbiol 38:168-81. 2012
  3. ncbi In vitro killing of microfilariae of Brugia pahangi and Brugia malayi by eosinophil granule proteins
    K J Hamann
    Department of Immunology, Mayo Medical School, Rochester, MN 55905
    J Immunol 144:3166-73. 1990
  4. ncbi Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity
    G J Swaminathan
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Biol Chem 276:26197-203. 2001
  5. ncbi Differential extraction of eosinophil granule proteins
    Lyo E Ohnuki
    Department of Dermatology, University of Utah, Salt Lake City, 84132, USA
    J Immunol Methods 307:54-61. 2005
  6. ncbi Serum eosinophil derived neurotoxin may reflect more strongly disease severity in childhood atopic dermatitis than eosinophil cationic protein
    S Taniuchi
    Department of Paediatrics, Kansai Medical University, Fumizonocho 10 15, Moriguchi, 570 8506, Osaka, Japan
    J Dermatol Sci 26:79-82. 2001
  7. ncbi Eosinophil granule proteins in peripheral blood granulocytes
    R I Abu-Ghazaleh
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905
    J Leukoc Biol 52:611-8. 1992
  8. ncbi Polymorphism of the eosinophil cationic protein-gene is related to the expression of allergic symptoms
    U B Jönsson
    Department of Medical Sciences and Asthma Research Centre, University of Uppsala, Uppsala, Sweden
    Clin Exp Allergy 32:1092-5. 2002
  9. ncbi Tissue eosinophilia in acute and chronic atopic dermatitis: a morphometric approach using quantitative image analysis of immunostaining
    P Kiehl
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str 5, D 30449 Hannover, Germany
    Br J Dermatol 145:720-9. 2001
  10. ncbi Two eosinophil granule proteins, eosinophil peroxidase and major basic protein, inhibit mucin release from hamster tracheal surface epithelial cells in primary culture
    K C Kim
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore 21201, USA
    Inflamm Res 48:314-7. 1999

Detail Information

Publications181 found, 100 shown here

  1. pmc The development of a sensitive and specific ELISA for mouse eosinophil peroxidase: assessment of eosinophil degranulation ex vivo and in models of human disease
    Sergei I Ochkur
    Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, Scottsdale, AZ 85259, United States
    J Immunol Methods 375:138-47. 2012
    ..The presence of extracellular eosinophil granule proteins in affected tissues is a well established and specific marker of eosinophil activation in both patients ..
  2. ncbi Antimicrobial activity of human eosinophil granule proteins: involvement in host defence against pathogens
    Anu Malik
    Immunochemistry Laboratory, National Institute of Immunology, New Delhi, India
    Crit Rev Microbiol 38:168-81. 2012
    ..The four major eosinophil granule proteins, major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil derived neurotoxin (EDN) and ..
  3. ncbi In vitro killing of microfilariae of Brugia pahangi and Brugia malayi by eosinophil granule proteins
    K J Hamann
    Department of Immunology, Mayo Medical School, Rochester, MN 55905
    J Immunol 144:3166-73. 1990
    ..Here, we performed in vitro assays of the toxicity of four purified eosinophil granule proteins, namely, MBP, EPO, eosinophil cationic protein (ECP), and eosinophil-derived neurotoxin (EDN), for the ..
  4. ncbi Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity
    G J Swaminathan
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    J Biol Chem 276:26197-203. 2001
    ..Our analysis suggests that EMBP specifically binds heparin. Based on our results, we propose a possible new function for this protein, which is likely to have implications for EMBP function...
  5. ncbi Differential extraction of eosinophil granule proteins
    Lyo E Ohnuki
    Department of Dermatology, University of Utah, Salt Lake City, 84132, USA
    J Immunol Methods 307:54-61. 2005
    ..These results indicate that repetitive extraction of eosinophil granules yields an increased amount of all granule proteins, and that MBP2 can now be recovered in good quantities and in a relatively pure form...
  6. ncbi Serum eosinophil derived neurotoxin may reflect more strongly disease severity in childhood atopic dermatitis than eosinophil cationic protein
    S Taniuchi
    Department of Paediatrics, Kansai Medical University, Fumizonocho 10 15, Moriguchi, 570 8506, Osaka, Japan
    J Dermatol Sci 26:79-82. 2001
    ..The skin scores were more significantly correlated with serum EDN levels than ECP levels. We concluded that serum EDN may reflect more strongly disease severity as eosinophilic activation in AD children than serum ECP...
  7. ncbi Eosinophil granule proteins in peripheral blood granulocytes
    R I Abu-Ghazaleh
    Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905
    J Leukoc Biol 52:611-8. 1992
    ..5; EDN, 72 +/- 9; and ECP, 50 +/- 12. Therefore we conclude that these proteins are mainly expressed in eosinophils, but that certain ones are present in basophils and neutrophils...
  8. ncbi Polymorphism of the eosinophil cationic protein-gene is related to the expression of allergic symptoms
    U B Jönsson
    Department of Medical Sciences and Asthma Research Centre, University of Uppsala, Uppsala, Sweden
    Clin Exp Allergy 32:1092-5. 2002
    ..This polymorphism would cause the change of the amino acid arginine (base at position 434 is G) at position 97 to threonine (base at position 434 is C)...
  9. ncbi Tissue eosinophilia in acute and chronic atopic dermatitis: a morphometric approach using quantitative image analysis of immunostaining
    P Kiehl
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str 5, D 30449 Hannover, Germany
    Br J Dermatol 145:720-9. 2001
    ..The frequency and amount of tissue eosinophilia in spontaneous lesions of acute and chronic atopic dermatitis (AD) are still a matter of controversy, and little is known about the distribution of eosinophilia in skin...
  10. ncbi Two eosinophil granule proteins, eosinophil peroxidase and major basic protein, inhibit mucin release from hamster tracheal surface epithelial cells in primary culture
    K C Kim
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore 21201, USA
    Inflamm Res 48:314-7. 1999
    ..Effects of eosinophil proteins on airway goblet cell mucin release were investigated using primary hamster tracheal surface epithelial (HTSE) cell cultures...
  11. ncbi Eosinophil granule proteins in the assessment of airway inflammation in pediatric bronchial asthma
    O D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 14:248-54. 2003
    b>Eosinophil granule proteins such as eosinophil cationic protein (ECP), eosinophil peroxidase (EPO) and eosinophil protein X (EPX) in serum and urine are indirect measures of eosinophil activity...
  12. ncbi Interactions of eosinophil granule proteins with skin: limits of detection, persistence, and vasopermeabilization
    Mark D P Davis
    Department of Dermatology, Mayo Clinic and Foundation, Rochester, Minn, USA
    J Allergy Clin Immunol 112:988-94. 2003
    b>Eosinophil granule proteins, including eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO), and major basic protein (MBP), are prominently deposited in skin in several cutaneous disorders ..
  13. ncbi Urine eosinophil protein X (EPX) is an in vitro parameter of inflammation in atopic dermatitis of the adult age
    K Breuer
    Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Strasse 5, D-30449 Hannover, Germany
    Allergy 56:780-4. 2001
    ..36, P<0.0001 and 0.34, P<0.0001, respectively). CONCLUSION: Urine EPX is a useful in vitro parameter of inflammation in atopic dermatitis of the adult age...
  14. ncbi Effects of human mast cell tryptase and eosinophil granule proteins on the kinetics of blood clotting
    Michael Samoszuk
    Pathology Department, University of California Irvine, UCI Medical Building 10, Route 40, 101 The City Drive, Orange, CA 92868 3298, USA
    Am J Hematol 73:18-25. 2003
    ..b>Eosinophil granule proteins and purified eosinophil peroxidase markedly reduced the anticoagulant properties of the mast cell ..
  15. ncbi Neutrophil and eosinophil granule proteins as markers of response to local prednisolone treatment in distal ulcerative colitis and proctitis
    P Sangfelt
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Am J Gastroenterol 96:1085-90. 2001
    ..05) in the response group and often occurred before clinical improvement. There was a nonsignificant trend toward a decrease in the concentrations of ECP and EPO at the end of treatment in responders...
  16. ncbi Double-blind, randomized, placebo-controlled trial of effect of nedocromil sodium on clinical and inflammatory parameters of asthma in children allergic to dust mite
    I Stelmach
    M. Curie Hospital, Department of Pediatrics and Allergy, Zgierz, Poland
    Allergy 56:518-24. 2001
    ..No correlation was found between any of the measured parameters. CONCLUSION: Nedocromil sodium provided effective anti-inflammatory treatment for children with moderate atopic asthma...
  17. ncbi Eosinophils and eosinophilic cationic protein in induced sputum and blood: effects of budesonide and terbutaline treatment
    Ruth E Aldridge
    Canterbury Respiratory Research Unit, Christchurch School of Medicine, University of Otago, Christchurch Hospital, Christchurch, New Zealand
    Ann Allergy Asthma Immunol 89:492-7. 2002
    ..Eosinophilic cationic protein (ECP) levels in sputum and blood correlate with clinical severity, and serial measurements of ECP have been proposed as a suitable candidate...
  18. ncbi Identification and characterization of human eosinophil cationic protein by an epitope-specific antibody
    E Boix
    Departament de Bioquimica i Biologia Molecular, Facultat de Ciencies, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    J Leukoc Biol 69:1027-35. 2001
    ....
  19. ncbi Comparison of anti-inflammatory and clinical effects of beclomethasone dipropionate and salmeterol in moderate asthma
    E Bacci
    Cardiothoracic Dept, University of Pisa, Cisaneelo Hospital, Italy
    Eur Respir J 20:66-72. 2002
    ..Beclomethasone also had an overall greater clinical effect, although the improvement in symptoms and peak expiratory flow variability was similar after both treatments...
  20. ncbi Serum eosinophil cationic protein levels measured during exacerbation of asthma: characteristics of patients with low titres
    H Matsumoto
    Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan
    Clin Exp Allergy 31:637-43. 2001
    ..Mechanisms other than eosinophilic inflammation, such as airway remodelling, may be involved in asthma exacerbation in these patients...
  21. ncbi Significance of the eosinophil cationic protein/eosinophil count ratio in asthmatic patients: its relationship to disease severity
    M Fujitaka
    Department of Pediatrics, Hiroshima University School of Medicine, Japan
    Ann Allergy Asthma Immunol 86:323-9. 2001
    ..CONCLUSIONS: The ECP/Eo ratio may be useful in assessing asthma severity; however, the serum ECP concentration or peripheral blood eosinophil count is not useful...
  22. ncbi Eosinophil markers in blood, serum, and urine for monitoring the clinical course in childhood asthma: impact of budesonide treatment and withdrawal
    K Lönnkvist
    Astrid Lindgren Children s Hospital, Stockholm and the Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Hospital, Stockholm
    J Allergy Clin Immunol 107:812-7. 2001
    ..Few studies have focused on the dynamics of airway inflammation as reflected by the activity of the eosinophils and their proteins after withdrawal of inhaled corticosteroids...
  23. ncbi Influence of different dosage schedules of inhaled fluticasone propionate on peripheral blood cytokine concentrations in childhood asthma
    M J Visser
    Department of Pulmonology, University Hospital Groningen, The Netherlands
    Clin Exp Allergy 32:1497-503. 2002
    ..Asthma is characterized by eosinophilic airways inflammation with elevated levels of IL-4, IL-5 and sICAM-1, and reduced levels of IL-10 and IFN-gamma. Inhaled corticosteroids powerfully reduce airways inflammation...
  24. ncbi Mild exacerbations and eosinophilic inflammation in patients with stable, well-controlled asthma after 1 year of follow-up
    J Belda
    Hospital de la Santa Creu i Sant Pau, Barcelona, Catalunya, Spain
    Chest 119:1011-7. 2001
    ..Eosinophilic inflammation expressed as eosinophil count and ECP is associated with higher risk of mild exacerbation...
  25. ncbi Effect of physical and chemical methods of homogenization on inflammatory mediators in sputum of asthma patients
    E Grebski
    Pulmonary Division, Department of Internal Medicine, University of Zurich, Switzerland
    Chest 119:1521-5. 2001
    ..CONCLUSIONS: The sputum processing by DTT caused a statistically significant fall in EPO and MPO concentrations but did not significantly influence the measured concentrations of ECP and EPX...
  26. ncbi Effect of suplatast tosilate on airway hyperresponsiveness and inflammation in asthma patients
    M Yoshida
    Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Higashiku, Fukuoka, Japan
    J Asthma 39:545-52. 2002
    ..These results strongly suggest that oral administration of suplatast tosilate suppresses airway hyperresponsiveness in asthma patients by reducing eosinophilic inflammation in the airways...
  27. ncbi [Effect of triamcinolone acetonide, montelukast, nedocromil sodium and formoterol on eosinophil blood counts, ECP serum levels and clinical progression of asthma in children]
    Iwona Stelmach
    Samodzielny Oddział Kliniczny Interny Dzieciecej i Alergologii Instytutu Pediatrii Akademii Medycznej w Łodzi
    Pol Merkur Lekarski 12:208-13. 2002
    ..This study shows that triamcinolon, montelukast contribute to inhibition of allergic inflammation by decreasing eosinophil blood counts and ECP. The serum level of ECP seems to be a good clinical marker of monitoring the disease...
  28. ncbi Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients
    Yasushi Obase
    Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan
    Chest 121:143-50. 2002
    ..Leukotrienes (LTs) are important in asthma, and LT modifiers modulate antigen-induced asthma. Overproduction of LT by suppression of cyclooxygenase activity is involved in patients with aspirin-intolerant asthma (AIA)...
  29. ncbi The inflammatory marker serum eosinophil cationic protein (ECP) compared with PEF as a tool to decide inhaled corticosteroid dose in asthmatic patients
    O Lowhagen
    Asthma and Allergy Research Group, Sahlgrenska University Hospital, Gothenburg, Sweden
    Respir Med 96:95-101. 2002
    ..Recommendations suggesting lung function tests in current guidelines may be difficult to translate into clinical practice, however, a combination of inflammatory markers, lung function and symptoms may still improve asthma control...
  30. ncbi Effect of budesonide on the perception of induced airway narrowing in subjects with asthma
    Cheryl M Salome
    Institute of Respiratory Medicine, University of Sydney, Sydney, New South Wales, Australia
    Am J Respir Crit Care Med 165:15-21. 2002
    ..We conclude that treatment with budesonide enhances the perception of airway narrowing, but the effect is unrelated to budesonide dose, or to changes in circulating eosinophil markers...
  31. ncbi Measurement of airway inflammation in asthma
    Nicola Wilson
    Department of Paediatrics, Royal Brompton and Harefield National Health Service Trust, London, United Kingdom
    Curr Opin Pulm Med 8:25-32. 2002
    ..However, application of these markers continues to further our understanding of the disease process and provides the potential for more appropriate, customized therapy...
  32. ncbi Down-regulated IL-5 receptor expression on peripheral blood eosinophils from budesonide-treated children with asthma
    C Hellman
    Department of Medicine, Division of Clinical Immunology and Allergy, Stockholm, Sweden
    Allergy 57:323-8. 2002
    ..The expression and function of cytokine receptors on peripheral blood eosinophils (PBE) from healthy and asthmatic children are poorly characterized...
  33. ncbi Effect of theophylline on airway inflammation in asthma
    J Yang
    Wuhan University People's Hospital, Wuhan 430060, China
    Acta Pharmacol Sin 22:475-80. 2001
    ..01), too. CONCLUSION: These results indicated that low dose theophylline had inhibitory action on airway inflammation in asthma with noticeable improvement of the patients' symptoms and lung function...
  34. ncbi Smoking and airway inflammation in patients with mild asthma
    G W Chalmers
    Department of Respiratory Medicine, Western Infirmary, Glasgow, UK
    Chest 120:1917-22. 2001
    ....
  35. ncbi A randomized, double-blind trial of the effect of glucocorticoid, antileukotriene and beta-agonist treatment on IL-10 serum levels in children with asthma
    I Stelmach
    Department of Paediatrics and Allergy, The M Curie Hospital, 35 Parzeczewska Str 95 100 Zgierz, Poland
    Clin Exp Allergy 32:264-9. 2002
    ..Triamcinolone has anti-inflammatory properties and the anti-inflammatory effects of montelukast and formoterol have been discussed...
  36. ncbi Sputum induction: effect of nebulizer output and inhalation time on cell counts and fluid-phase measures
    J Belda
    The Asthma Research Group, Department of Medicine and Nuclear Medicine, St Joseph' s Healthcare and McMaster University, Hamilton, Ontario, Canada
    Clin Exp Allergy 31:1740-4. 2001
    ..The results draw attention to the need to standardize the volume and time of nebulization to accurately interpret and compare results...
  37. ncbi Comparison of hydrofluoroalkane-beclomethasone dipropionate Autohaler with budesonide Turbuhaler in asthma control
    H Worth
    Medizinische Klinik I, , Germany
    Respiration 68:517-26. 2001
    ..36 for HFA-BDP and -4.88 for BUD TH (p < 0.01). CONCLUSIONS: HFA-BDP 800 microg x day(-1) provided control of moderate-to-severe asthma with efficacy and safety at least similar to BUD TH 1,600 microg x day(-1)...
  38. ncbi Sputum eosinophilia in Churg-Strauss syndrome
    H Meziane
    Clinique des Maladies Respiratoires and INSERM U 454, Hospital Arnaud deVilleneuve, CHU Montpellier, France
    Respir Med 95:799-801. 2001
    ..Eosinophil percentage in sputum and the total number of eosinophils in peripheral blood were more predictive of exacerbations of CSS than sputum ECP...
  39. ncbi Airway neutrophil inflammation in nonasthmatic patients with food allergy
    Benoit Wallaert
    Clinique des Maladies Respiratoires, Service de Pneumologie et Immuno Allergologie, hôpital A Calmette, CHRU Lille, 59037 Lille Cedex, France
    Allergy 57:405-10. 2002
    ..In order to explain this observation, we sought to examine the presence of a bronchial inflammation in induced sputum of nonasthmatic patients with FA...
  40. ncbi A comparison of clinical use of fluticasone propionate and beclomethasone dipropionate in pediatric asthma
    B R Nong
    Department of Pediatrics, Veteran General Hospital-Kaohsiung, No. 386, Ta-Chung 1st Road, Kaohsiung, Taiwan
    Kaohsiung J Med Sci 17:302-11. 2001
    ..In conclusion, native data indicated that the potency of 100 micrograms of FP was equal to that of 200 micrograms of BD and that few side effects were noted in FP group. It is recommended that this drug be introduced for clinical use...
  41. ncbi Increased CD69 expression on peripheral blood eosinophils after specific inhalation challenge
    Patrizia Pignatti
    Servizio Autonomo di Allergologia e Immunologia Clinica, Fondazione S Maugeri, IRCCS, Istituto Scientifico di Pavia, Centro Medico di Pavia, Loc Cravino, Via Ferrata 8, 27100 Pavia, Italy
    Allergy 57:411-6. 2002
    ....
  42. ncbi [The relationship between eosinophils, activated T lymphocyte, leukotreine and the exercise-induced asthma]
    Y Guo
    Department of Respiratory Medicine, Beijing Hospital, Beijing 100730, China
    Zhonghua Jie He He Hu Xi Za Zhi 24:360-4. 2001
    ..CONCLUSIONS: Hyperventilation during exercise may not be the cause leading to EIA, neither did the activation of T lymphocytes, IL-4 and IL-5 gene expression nor ECP. Leukotriene may play an important role in the pathogenesis of EIA...
  43. ncbi Liposome-entrapped D. pteronyssinus vaccination in mild asthma patients: effect of 1-year double-blind, placebo-controlled trial on inflammation, bronchial hyperresponsiveness and immediate and late bronchial responses to the allergen
    M J Alvarez
    Department of Allergy, Hospital Virgen del Camino, Pamplona, Spain
    Clin Exp Allergy 32:1574-82. 2002
    ..Allergen vaccination is effective in mite-allergic asthma. Liposomes are immunological adjuvants that can act as allergen carriers...
  44. ncbi Acupuncture and bronchial asthma: a long-term randomized study of the effects of real versus sham acupuncture compared to controls in patients with bronchial asthma
    Tullio C Medici
    Department of Internal Medicine, University Hospital Zurich, Switzerland
    J Altern Complement Med 8:737-50; discussion 751-4. 2002
    ..Although there are many published studies on acupuncture and asthma, few meet the scientific criteria necessary to prove the effectiveness of acupuncture...
  45. ncbi Assessment of inhaled BDP-dose dependency of exhaled nitric oxide and local and serum eosinophilic markers in steroids-naive nonatopic asthmatics
    R Dal Negro
    Lung Department, Hospital of Bussolengo, Verona, Italy
    Allergy 58:1018-22. 2003
    ....
  46. ncbi [Pathophysiology of airway hyperresponsiveness, the importance of early intervention in the treatment of asthma]
    Terufumi Shimoda
    Nihon Kokyuki Gakkai Zasshi 41:606-10. 2003
  47. ncbi Absence of association of peripheral blood eosinophilia or increased eosinophil cationic protein with bronchial hyperresponsiveness during asthma remission
    Young Yull Koh
    Department of Pediatrics and Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
    Ann Allergy Asthma Immunol 91:297-302. 2003
    ..The mechanisms responsible for persistent bronchial hyperresponsiveness (BHR) in adolescents with long-term asthma remission are poorly understood...
  48. ncbi Increased prostaglandin E2 concentrations and cyclooxygenase-2 expression in asthmatic subjects with sputum eosinophilia
    Mirella Profita
    Institute of Lung Pathophysiology, Italian National Research Council, Palermo, Italy
    J Allergy Clin Immunol 112:709-16. 2003
    ..Recently it has been reported that PGE2 can enhance eosinophil survival in vitro...
  49. ncbi [Clinical effects of long-term administration of pranlukast, a leukotriene receptor antagonist, on adult patients with bronchial asthma]
    Takahiko Horiguchi
    Department of Internal Medicine, Fujita Health University Second Hospital, 3 6 10 Otobashi, Nakagawa Ku, Nagoya, 454 8509, Japan
    Nihon Kokyuki Gakkai Zasshi 41:696-703. 2003
    ..One year after medication was suspended, Group III showed a significant increase in the number of night visits to a medical facility and a rise in the serum ECP level. These findings indicated the efficacy of pranlukast...
  50. ncbi Efficacy of a short course of parent-initiated oral prednisolone for viral wheeze in children aged 1-5 years: randomised controlled trial
    Abraham Oommen
    Leicester Children s Asthma Centre, Institute for Lung Health, University of Leicester, Leicester, UK
    Lancet 362:1433-8. 2003
    ..However, evidence for this treatment strategy is conflicting. We therefore aimed to assess the efficacy of a short course of oral prednisolone for preschool viral wheeze, with stratification for systemic eosinophil priming...
  51. ncbi Effect of inhaled beclomethasone dipropionate on peroxynitrite inhibitory activity in induced sputum from asthmatic patients
    Hiroshi Kanazawa
    Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
    Chest 124:1755-61. 2003
    ..Therefore, this study was designed to examine the effect of inhaled beclomethasone dipropionate (BDP) on peroxynitrite inhibitory activity in induced sputum from asthmatic patients...
  52. ncbi Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children
    Robert C Strunk
    Washington University School of Medicine, St Louis, MO, USA
    J Allergy Clin Immunol 112:883-92. 2003
    ..Insufficient information is available concerning correlations between eNO and biologic, physiologic, and clinical characteristics of asthma in children currently not taking controller medications...
  53. ncbi [The effect of suplatast tosilate on the patients with atopic dermatitis--relationship between clinical symptoms and immunological parameters]
    Naoyuki Higashi
    Department of Dermatology, Nippon Medical School
    Arerugi 52:1065-73. 2003
    ..7) There was no sign of adverse effects of the drug. From the above mentioned results, we confirmed the high efficacy of suplatast tosilate in the treatment of atopic dermatitis...
  54. ncbi [Effects of interleukin-1 receptor antagonist on the apoptosis of eosinophil in guinea pig with asthma]
    Feng Xu
    Medical and Pharmacological, Institute of Yangzhou University, Yangzhou 225001, China
    Yao Xue Xue Bao 38:661-4. 2003
    ..To evaluate the effect of interleukin-1 receptor antagonist(IL-1ra) on apoptosis and associated mechanism of eosinophil in guinea pig with asthma...
  55. ncbi Effect of nasal triamcinolone acetonide on seasonal variations of bronchial hyperresponsiveness and bronchial inflammation in nonasthmatic children with seasonal allergic rhinitis
    Fazil Orhan
    Faculty of Medicine, Department of Pediatric Allergy, Hacettepe University, Ankara, Turkey
    Ann Allergy Asthma Immunol 92:438-45. 2004
    ..Recent evidence suggests that patients with allergic rhinitis have lower airway inflammation and a higher prevalence of bronchial hyperresponsiveness (BHR) regardless of asthma...
  56. ncbi Clinical evaluation of a transdermal therapeutic system of the beta2-agonist tulobuterol in patients with mild or moderate persistent bronchial asthma
    Takahiko Horiguchi
    Department of Internal Medicine, Fujita Health University Second Hospital, Nagoya, Aichi, Japan
    Arzneimittelforschung 54:280-5. 2004
    ....
  57. ncbi The ECP/Eo count ratio in children with asthma
    Iwona Stelmach
    Department of Pediatrics and Allergy, M Curie Hospital, Zgierz, Poland
    J Asthma 41:539-46. 2004
    ..84; 95% CI: 1.02-3.34) a risk of moderate asthma. These data show that the ECP/Eo ratio is a better and more useful marker than ECP or peripheral blood eosinophil count separately in assessing asthma in children...
  58. pmc Nitric oxide metabolites, eosinophils, and eosinophilic cationic protein in patients with asthma: sputum versus blood
    An Soo Jang
    Department of Internal Medicine, Cheju National University College of Medicine, Jeju, Korea
    J Korean Med Sci 18:489-93. 2003
    ..These findings suggest that the proportion of eosinophils in sputum have more accurate diagnostic marker of asthmatic airway inflammation than NO metabolites in sputum in differentiating asthmatic patients from control subjects...
  59. ncbi [The influence oc glycocorticoid therapy on sputum ECP concentration in symptomatic patients with bronchial asthma]
    Joanna Hermanowicz-Salamon
    Klinika i Katedra Chorób Wewnetrznych, Pneumonologii i Alergologii Akademii Medycznej w Warszawie
    Pneumonol Alergol Pol 70:527-35. 2002
    ..7 +/- 9.4 mcg/L, higher than in controls 12 +/- 5.8 mcg/L (p = 0.04). There were a significant correlations between total eosinophil count and serum (r = 0.6396) and sputum ECP(r = 0.4683) in exacerbation...
  60. ncbi High eosinophil cationic protein level in asthmatic patients with "heat" Zheng
    Ching Hsaing Hsu
    Department of Pediatric, China Medical College Hospital, Taichung, Taiwan
    Am J Chin Med 31:277-83. 2003
    ..Therefore, we conclude that ECP in asthmatic patients plays an important role in the development of "heat" manifestations as diagnosed by TCM...
  61. ncbi Antigen-specific IgE and IgA antibodies in bronchoalveolar lavage fluid are associated with stronger antigen-induced late phase reactions
    R S Peebles
    Divisions of Clinical Immunology and Pulmonary and Critical Care Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, Maryland 21224, USA
    Clin Exp Allergy 31:239-48. 2001
    ..The results of this study point towards the possibility that allergen-specific IgE and IgA may be independently involved in the pathogenesis of the late phase reaction. This notion merits further exploration...
  62. ncbi Eosinophil cationic protein and specific IgE in serum and nasal mucosa of patients with grass-pollen-allergic rhinitis and asthma
    F Marcucci
    Institute of Pediatrics, University of Perugia, Italy
    Allergy 56:231-6. 2001
    ..CONCLUSIONS: Both specific IgE and ECP in the nasal mucosa showed a better correlation with allergen exposure than serum evaluations. With an appropriate method, allergic inflammation may be best monitored in the nasal mucosa...
  63. ncbi Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome
    Hans Uwe Simon
    Department of Pharmacology, University of Bern, Bern, Switzerland
    Eur J Immunol 33:834-9. 2003
    ..These data suggest that patients with increased eosinophil surface CD25 expression are at higher risk of eosinophil degranulation and subsequent tissue damage when IL-2 is present at inflammatory sites...
  64. ncbi Eosinophils and eosinophil products in asthma
    Waseem Saeed
    Department of Pulmonology, Military Hospital, Pakistan
    J Ayub Med Coll Abbottabad 14:49-55. 2002
    ..Eosinophil-mediated damage to the respiratory epithelium is a major pathogenetic mechanism in asthma. This article is a review of the latest works about the relationship of eosinophil and eosinophil products with asthma...
  65. ncbi The relationship between inflammation and dipalmitoyl phosphatidycholine in induced sputum of children with asthma
    Anne B Chang
    Flinders University Northern Territory Clinical School, Alice Springs Hospital, Northern Territory, Australia
    J Asthma 40:63-70. 2003
    ..In this study we hypothesized that the degree of inflammation influences the level of dipalmitoyl phosphatidycholine (DPPC) in airways of children with asthma...
  66. ncbi Surplus value of eosinophil count and ECP to diagnose and monitor asthmatic patients
    C J Pronk-Admiraal
    Laboratory of Clinical Chemistry, Haematology and Immunology Medical Centre, Postbus 501 1800 AM Alkmaar, The Netherlands
    Neth J Med 58:9-17. 2001
    ..The additional value of serum ECP concentrations and eosinophil counts to detect an asthmatic constitution for individual cases is doubtful...
  67. ncbi Macrophage migration inhibitory factor (MIF) in bronchial asthma
    E Yamaguchi
    The First Department of Medicine, School of Medicine, Hokkaido University, Japan
    Clin Exp Allergy 30:1244-9. 2000
    ..Airways inflammation is a central feature of bronchial asthma and is characterized by the accumulation of eosinophils...
  68. ncbi Effects of low dose fluticasone/salmeterol combination on surrogate inflammatory markers in moderate persistent asthma
    G P Currie
    Asthma and Allergy Research Group Department of Pathology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Allergy 58:602-7. 2003
    ..We wished to examine the effects of low dose fluticasone/salmeterol combination on different commonly used inflammatory markers in moderate persistent asthma...
  69. ncbi A randomized controlled trial on the effect of montelukast on sputum eosinophil cationic protein in children with corticosteroid-dependent asthma
    Elke Strauch
    Mathildenstrabetae 1, D 79106 Freiburg, Germany
    Pediatr Res 54:198-203. 2003
    ..05), or eosinophil count (p > 0.05) was found. In conclusion, add-on treatment with montelukast can suppress sputum ECP in children with steroid-dependent asthma, while at the same time an improvement in quality of life items occurs...
  70. ncbi Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma
    Ronina A Covar
    Ira J and Jacqueline Neimark Laboratory of Clinical Pharmacology and the Division of Allergy Clinical Immunology, Department of Pediatrics, Denver, Colorado, USA
    J Pediatr 142:469-75. 2003
    ..Exhaled nitric oxide (FE(NO)) was evaluated in children with asthma after 4 to 6 years of treatment with budesonide, nedocromil, or albuterol as needed...
  71. ncbi The effect of seratrodast on eosinophil cationic protein and symptoms in asthmatics
    Toshihiko Fukuoka
    The Pulmonary Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    J Asthma 40:257-64. 2003
    ..Seratrodast may be useful as an anti-inflammatory agent and beneficial when added to inhaled corticosteroids in the treatment of bronchial asthma...
  72. ncbi Roles of genotypes of beta2-adrenergic receptor in the relationship between eosinophil counts and lung function in Taiwanese adolescents
    Ying Chu Lin
    Graduate Institute of Environmental and Occupational Health, National Cheng Kung University, College of Medicine, Tainan, Taiwan
    J Asthma 40:265-72. 2003
    ..The association between an increase of EOS and lower lung function can be differentiated by beta2AR genotypes at amino acid 16...
  73. ncbi Circulating fibrosis markers, eosinophil cationic protein and eosinophil protein X in patients with Wuchereria bancrofti infection: association with clinical status
    P Esterre
    Immunology Unit, Institut de Recherches Medicales Malarde, Papeete, Tahiti, French Polynesia
    Parasite 13:165-70. 2006
    ..of several circulating fibrosis markers (type I collagen I, type III procollagen, hyaluronan) and eosinophil granule proteins (ECP and EPX) in lymphatic filariosis patients to investigate their relationship with clinical, ..
  74. ncbi Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils
    F Levi-Schaffer
    Department of Allergy and Clinical Immunology, Royal Brompton Hospital, London, UK
    Blood 85:2579-86. 1995
    ..Dot blot analysis with specific monoclonal antibodies (MoAbs) was used to detect the eosinophil granule proteins major basic protein (MBP) and eosinophil cationic protein (ECP)...
  75. ncbi Serum eosinophil granule proteins predict asthma risk in allergic rhinitis
    L P Nielsen
    Departments of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark
    Allergy 64:733-7. 2009
    ..It is important to characterize these patients, thereby offering the possibility for prevention. This study evaluated eosinophil parameters as potential indicators of deteriorating allergic airway disease...
  76. pmc Vesicle-mediated secretion of human eosinophil granule-derived major basic protein
    Rossana C N Melo
    Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil
    Lab Invest 89:769-81. 2009
    ..of inflammation noted losses of granule cores in the absence of granule exocytosis and suggested that eosinophil granule proteins might be released through piecemeal degranulation (PMD), a secretory process mediated by transport ..
  77. ncbi Eosinophils alter colonic epithelial barrier function: role for major basic protein
    Glenn T Furuta
    Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Gastrointest Liver Physiol 289:G890-7. 2005
    ..In conclusion, MBP decreases epithelial barrier function and in this manner contributes to the pathogenesis of inflammatory bowel diseases...
  78. ncbi Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily
    K J Hamann
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905
    Genomics 7:535-46. 1990
    Human genomic DNAs for the eosinophil granule proteins, eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP), were isolated from genomic libraries...
  79. ncbi High vascular endothelial growth factor levels in NZW mice do not correlate with collagen deposition in allergic asthma
    Luciana M C Vasquez-Pinto
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Int Arch Allergy Immunol 142:19-27. 2007
    ..Eosinophil peroxidase (EPO) is one of the eosinophil granule proteins involved in the early response, but its participation in airway remodeling is not established...
  80. ncbi Inflammation and cell-cell interactions in airway hyperresponsiveness
    A R Leff
    Department of Medicine, University of Chicago, Illinois 60637
    Am J Physiol 260:L189-206. 1991
    ..The molecular biology of the eosinophil granule proteins has characterized four distinct substances, each of which exerts potential cytotoxic effects on airway ..
  81. ncbi Evidence for eosinophil degranulation in acute appendicitis
    G Santosh
    Department of Pathology, Medical College, Calicut 673 008, Kerala, India
    Indian J Pathol Microbiol 51:172-4. 2008
    ..This study aimed to measure the eosinophil degranulation resulting in a rise in the serum of eosinophil granule proteins that would be expected in such cases...
  82. ncbi Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells
    Kim Doan Katrina Nguyen
    Division of Pediatric Gastroenterology, Hepatology, and Nutrition, SUNY Downstate Medical Center, Brooklyn, NY, USA
    J Pediatr Gastroenterol Nutr 51:556-62. 2010
    ..Eosinophilic esophagitis mimics GERD, but eosinophil granule proteins, known to mediate inflammation, have not been linked to BE...
  83. pmc Eosinophil infiltration and degranulation in oesophageal mucosa from adult patients with eosinophilic oesophagitis: a retrospective and comparative study on pathological biopsy
    S Mueller
    Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany
    J Clin Pathol 59:1175-80. 2006
    ..To examine eosinophil infiltration and degranulation in 50 oesophageal biopsy specimens from 30 patients (21 men, 9 women; mean 39 years) with eosinophilic oesophagitis, by haematoxylin and eosin staining and immunohistochemistry...
  84. ncbi Eosinophil granule proteins and their role in disease
    G M Walsh
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Foresterhill, UK
    Curr Opin Hematol 8:28-33. 2001
    ..This review will update recent developments in understanding the role that eosinophil granule proteins play in human disease, particularly those of the respiratory tract.
  85. ncbi CD48 is an allergen and IL-3-induced activation molecule on eosinophils
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Immunol 177:77-83. 2006
    ..Furthermore, cross-linking CD48 on human eosinophils triggers release of eosinophil granule proteins. Assessment of CD48 expression in a murine model of experimental asthma revealed that CD48 is induced ..
  86. pmc Eosinophil granules function extracellularly as receptor-mediated secretory organelles
    Josiane S Neves
    Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:18478-83. 2008
    ..ligand-responsive, secretion-competent structures constitute a novel postcytolytic mechanism for regulated secretion of eosinophil granule proteins that may contribute to eosinophil-mediated inflammation and immunomodulation.
  87. ncbi Eosinophil degranulation status in allergic rhinitis: observations before and during seasonal allergen exposure
    C A Ahlstrom-Emanuelsson
    Department of Otorhinolaryngology, Head and Neck Surgery, Lund University Hospital, 221 84 Lund, Sweden
    Eur Respir J 24:750-7. 2004
    ..In association with the development of symptomatic seasonal allergic rhinitis, the tissue deposition of eosinophil granule proteins is dramatically elevated through increased eosinophil numbers, together with markedly augmented ..
  88. pmc Interleukin-16 expression and release in bullous pemphigoid
    A Frezzolini
    Laboratory of Immunology and Allergology, Istituto Dermopatico dell Immacolata, IDI IRCCS, Rome, Italy
    Clin Exp Immunol 137:595-600. 2004
    ....
  89. ncbi Longitudinal case analysis in atopic dermatitis
    P Helmbold
    Department of Dermatology, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Acta Derm Venereol 80:348-52. 2000
    ..In conclusion, longitudinal time-series analysis might represent an interesting and adequate method to generate and test new hypotheses on biomedical problems which cannot be addressed by cross-sectional studies...
  90. ncbi [Eosinophil cationic protein in serum of children with food allergy]
    Elzbieta Maciorkowska
    III Klinika Chorob Dzieci, Akademii Medycznej w Białymstoku
    Pol Merkur Lekarski 14:13-6. 2003
    ..The studies indicate that the exclusive evaluation of ECP concentration in serum does not reflect unequivocally the severity of pathological changes of gastric mucosa in children with food allergy...
  91. ncbi Crystal structure of eosinophil cationic protein at 2.4 A resolution
    E Boix
    Department of Biology and Biochemistry, University of Bath, UK
    Biochemistry 38:16794-801. 1999
    ..The structure also shows how the cationic residues are distributed on the surface of the ECP molecule that may have implications for an understanding of the cytotoxicity of this enzyme...
  92. ncbi Clinical assessment of asthma severity partially corresponds to sputum eosinophilic airway inflammation
    M L Bartoli
    Cardiothoracic Department, Respiratory Pathophysiology, Ospedale di Cisanello, University of Pisa, Via Paradisa 2, Pisa 56124, Italy
    Respir Med 98:184-93. 2004
    ..In conclusion, the assessment of asthma severity according to clinical and functional findings only partially corresponds to the severity of eosinophilic airway inflammation as assessed by induced sputum analysis...
  93. ncbi Inflammation markers and symptom activity in children with bronchial asthma. Influence of atopy and eczema
    K H Carlsen
    Voksentoppen Center of Asthma, Allergy and Chronic Lung Diseases in Children, Oslo, Norway
    Pediatr Allergy Immunol 8:112-20. 1997
    ..However, the relative impact of asthma symptoms and atopic eczema upon serum (s)-ECP in asthmatic children has not been established...
  94. ncbi The effects of an anti-CD11a mAb, efalizumab, on allergen-induced airway responses and airway inflammation in subjects with atopic asthma
    Gail M Gauvreau
    Department of Medicine, McMaster University, Health Sciences Centre, Hamilton, ON, Canada
    J Allergy Clin Immunol 112:331-8. 2003
    ..Blocking of LFA-1/intercellular adhesion molecule interactions could inhibit asthmatic inflammation by blocking adhesion and activation of LFA-1-positive leukocytes...
  95. ncbi Nasal patency and biomarkers in nasal lavage--the significance of air exchange rate and type of ventilation in schools
    R Wålinder
    Department of Occupational and Environmental Medicine, Uppsala University Hospital, Sweden
    Int Arch Occup Environ Health 71:479-86. 1998
    ..The aim of the present study was to examine the relationships between the ventilation rate and the type of ventilation system, on the one hand, and objective nasal measures, on the other...
  96. ncbi Ratio of eosinophil cationic protein/eosinophil count as a new marker in children with acute asthma
    C Imai
    Department of Pediatrics, Niigata University School of Medicine, Japan
    Pediatr Int 41:142-6. 1999
    ..It is a matter of concern whether serum eosinophil cationic protein (ECP) can be considered as a disease marker in children with acute asthma being treated without corticosteroids...
  97. ncbi CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma
    T Jinquan
    Laboratory of Medical Allergology, Allergy Unit, National University Hospital, University of Copenhagen, Copenhagen, Denmark
    J Immunol 165:1548-56. 2000
    ....
  98. pmc Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines
    P Romagnani
    Department of Physiopathology, Section of Clinical Immunology, University of Florence, Florence, Italy
    Am J Pathol 155:1195-204. 1999
    ..Our findings indicate that these chemokines may play an important role in the differentiation and/or migration of this mast cell subset in connective tissues, as well as in sites of allergic inflammation...
  99. ncbi Serum levels of eosinophilic cationic protein (ECP), myeloperoxidase (MPO), lipid peroxidation products, interleukin (IL)-5 and interferon (IFN)-gamma in children with bronchial asthma at acute asthma attack and remission
    O Kalayci
    Hacettepe University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey
    Turk J Pediatr 42:9-16. 2000
    ..Serum IL-5 and IFN-gamma levels are not appropriate for use in the follow-up of asthmatic children...
  100. ncbi Matrix metalloproteinase-9, its tissue inhibitor(TIMP)-1 and CRP in Alzheimer's disease
    Michael Inspector
    Neuroimmunology Unit, Carmel Medical Center, Haifa, Israel
    Eur Neurol 53:155-7. 2005
  101. ncbi Urinary eosinophil protein X in children with asthma: influence of atopy and airway infections
    K Oymar
    Department of Pediatrics, Rogaland Central Hospital, Stavanger, Norway
    Pediatr Allergy Immunol 12:34-41. 2001
    ....

Research Grants12

  1. Eosinophil Granule Proteins and Their Functions
    Gerald Gleich; Fiscal Year: 2006
    ..Under the auspices of this grant, we have investigated the structure and function of eosinophil granule proteins, including major basic protein (MBP1), eosinophil-derived neurotoxin (EDN), eosinophil cationic protein ..
  2. Role of Spi-C in eosinophil development and functional responses
    PATRICIA CHANDHOK FULKERSON; Fiscal Year: 2013
    ..differentiation, survival and effector function via regulation of IL-5Ra expression and expression of eosinophil granule proteins. Defining the molecular regulators of eosinophil function and IL-5 responsiveness will undoubtedly ..
  3. Mouse Models of Eosinophil-Associated Lung Dysfunction
    Nancy A Lee; Fiscal Year: 2013
    ..define the pulmonary remodeling events, including induced lung dysfunction, mediated by the release of eosinophil granule proteins. PUBLIC HEALTH RELEVANCE: The scientific literature abounds with studies which question whether the ..
  4. Novel minimally invasive assessment of gastrointestinal inflammation in food alle
    Glenn Furuta; Fiscal Year: 2009
    ..using the EST, performing measurements of specific eosinophil-expressed inflammatory mediators (eosinophil granule proteins), to determine their associations with the histopathologic features of EE disease...
  5. CARDIOTOXICITY OF EOSINOPHIL GRANULE CATIONIC PROTEINS
    Helene Rosenberg; Fiscal Year: 1991
    ..to identify functionally significant amino acid sequences and to clarify the mechanisms by which the eosinophil granule proteins interact with their cardiovascular targets...
  6. EOSINOPHIL LEUKOCYTES AND ATOPIC DERMATITIS
    KRISTIN LEIFERMAN; Fiscal Year: 1993
    ..Second, because high concentrations of toxic eosinophil granule proteins are deposited in the skin, the effects of granule proteins on epithelium and mast cells will be ..
  7. Global Gene Expression in Chronic Rhinosinusitis
    DOUGLAS PLAGER; Fiscal Year: 2005
    ..These new molecular approaches should shed light on the mechanisms of CRS and open novel avenues for diagnosis and treatment of this difficult disease. ..
  8. Mechanisms of Eosinophilic Inflammation in Human Asthma
    Hirohito Kita; Fiscal Year: 2005
    ..abstract_text> ..
  9. Planning a Multicenter Oral Itraconazole Trial in Chronic Rhinosinusitis Patients
    Hirohito Kita; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. MECHANISMS OF EOSINOPHIL DEGRANULATION IN HUMAN DISEASE
    Hirohito Kita; Fiscal Year: 2010
    ..Relevance: Patients with asthma have persistent respiratory problems. This research will investigate how the interaction of immune cells and our environment cause and worsen the disease. ..
  11. Neutrophils and HIV-1 infection
    Larry Thomas; Fiscal Year: 2006
    ..It is predicted that the results of this study will provide a basis for expanded and detailed analysis for potential and previously unrecognized involvement of neutrophils in HIV-1 transmission and disease. ..
  12. HIV and Neutrophil Function in Oral Disease
    Larry Thomas; Fiscal Year: 2003
    ..As such, the results may provide an additional target to enhance innate immunity within the oral cavity and also to decrease the vertical transmission of HIV in breast milk. ..