oxyhemoglobins

Summary

Summary: A compound formed by the combination of hemoglobin and oxygen. It is a complex in which the oxygen is bound directly to the iron without causing a change from the ferrous to the ferric state.

Top Publications

  1. ncbi Multichannel near-infrared spectroscopy in depression and schizophrenia: cognitive brain activation study
    Tomohiro Suto
    Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Gunma, Japan
    Biol Psychiatry 55:501-11. 2004
  2. ncbi Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model
    Y Hoshi
    Biophysics Group, Research Institute for Electronic Science, Hokkaido University, Sapporo 060 0812, Japan
    J Appl Physiol (1985) 90:1657-62. 2001
  3. pmc HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain
    Theodore J Huppert
    Departments of Radiology and Bioengineering, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Appl Opt 48:D280-98. 2009
  4. pmc Simultaneous mapping of temporally-resolved blood flow velocity and oxygenation in femoral artery and vein during reactive hyperemia
    Michael C Langham
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Cardiovasc Magn Reson 13:66. 2011
  5. ncbi DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study
    Philippa A Jackson
    Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK
    Br J Nutr 107:1093-8. 2012
  6. ncbi Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation
    Andrew K Dunn
    Athinoula A Martinos Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Opt Lett 28:28-30. 2003
  7. pmc Short separation channel location impacts the performance of short channel regression in NIRS
    Louis Gagnon
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 59:2518-28. 2012
  8. ncbi Impairment of 3000-m run time at altitude is influenced by arterial oxyhemoglobin saturation
    Robert F Chapman
    Human Performance Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN, USA
    Med Sci Sports Exerc 43:1649-56. 2011
  9. pmc Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging
    Amr Yafi
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, Calif 92617, USA
    Plast Reconstr Surg 127:117-30. 2011
  10. pmc Cerebral and peripheral tissue oxygenation in children supported on ECMO for cardio-respiratory failure
    Maria D Papademetriou
    Biomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK
    Adv Exp Med Biol 662:447-53. 2010

Detail Information

Publications251 found, 100 shown here

  1. ncbi Multichannel near-infrared spectroscopy in depression and schizophrenia: cognitive brain activation study
    Tomohiro Suto
    Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Gunma, Japan
    Biol Psychiatry 55:501-11. 2004
    ..Recent developments in near-infrared spectroscopy (NIRS) have enabled the noninvasive clarification of brain functions in psychiatric disorders with measurement of hemoglobin concentrations as cerebral blood volume...
  2. ncbi Interpretation of near-infrared spectroscopy signals: a study with a newly developed perfused rat brain model
    Y Hoshi
    Biophysics Group, Research Institute for Electronic Science, Hokkaido University, Sapporo 060 0812, Japan
    J Appl Physiol (1985) 90:1657-62. 2001
    ....
  3. pmc HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain
    Theodore J Huppert
    Departments of Radiology and Bioengineering, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Appl Opt 48:D280-98. 2009
    ..These methods are described within the context of the MATLAB-based graphical user interface program, HomER, which we have developed and distributed to facilitate the processing of optical functional brain data...
  4. pmc Simultaneous mapping of temporally-resolved blood flow velocity and oxygenation in femoral artery and vein during reactive hyperemia
    Michael C Langham
    Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    J Cardiovasc Magn Reson 13:66. 2011
    ..Here we demonstrate the feasibility of a simultaneous measurement of blood flow and HbO2 in the femoral circulation as part of a single procedure...
  5. ncbi DHA-rich oil modulates the cerebral haemodynamic response to cognitive tasks in healthy young adults: a near IR spectroscopy pilot study
    Philippa A Jackson
    Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK
    Br J Nutr 107:1093-8. 2012
    ..These encouraging pilot data warrant further application of NIRS in this area...
  6. ncbi Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation
    Andrew K Dunn
    Athinoula A Martinos Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Opt Lett 28:28-30. 2003
    ..This is of significance to the neuroscience community and will lead to a better understanding of the interrelationship of neural, metabolic, and hemodynamic processes in normal and diseased brains...
  7. pmc Short separation channel location impacts the performance of short channel regression in NIRS
    Louis Gagnon
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 59:2518-28. 2012
    ..Using small separations located farther than 2 cm away resulted in mild or negligible improvements only...
  8. ncbi Impairment of 3000-m run time at altitude is influenced by arterial oxyhemoglobin saturation
    Robert F Chapman
    Human Performance Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN, USA
    Med Sci Sports Exerc 43:1649-56. 2011
    ..The decline in maximal oxygen uptake (ΔVO(2)max) with acute exposure to moderate altitude is dependent on the ability to maintain arterial oxyhemoglobin saturation (SaO2)...
  9. pmc Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging
    Amr Yafi
    Beckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, Calif 92617, USA
    Plast Reconstr Surg 127:117-30. 2011
    ..The purpose of this study was to investigate the capabilities of a novel optical wide-field imaging technology known as spatial frequency domain imaging to quantitatively assess reconstructive tissue status...
  10. pmc Cerebral and peripheral tissue oxygenation in children supported on ECMO for cardio-respiratory failure
    Maria D Papademetriou
    Biomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK
    Adv Exp Med Biol 662:447-53. 2010
    ..Spectral analysis was performed on the oxyhaemoglobin data collected from these patients with the aim of comparing oscillations at range of frequencies appearing in the two measurement sites...
  11. ncbi Alterations in prefrontal cortical activity in the course of treatment for late-life depression as assessed on near-infrared spectroscopy
    Yasunori Onishi
    Department of Psychiatry, Jichi Medical University, Shimotsuke, Japan
    Psychiatry Clin Neurosci 62:177-84. 2008
    ..To evaluate the severity of depression by measuring alterations in prefrontal cortical activity associated with mood disorders, as assessed on near-infrared spectroscopy...
  12. pmc First-in-human pilot study of a spatial frequency domain oxygenation imaging system
    Sylvain Gioux
    Beth Israel Deaconess Medical Center, Division of Hematology Oncology, Department of Medicine, Boston, Massachusetts 02215, USA
    J Biomed Opt 16:086015. 2011
    ..Overall, this study lays the foundation for clinical translation of endogenous contrast imaging using SFDI...
  13. ncbi Influence of skin blood flow on near-infrared spectroscopy signals measured on the forehead during a verbal fluency task
    Toshimitsu Takahashi
    Department of Neurophysiology, Juntendo University Graduate School of Medicine, Tokyo, Japan
    Neuroimage 57:991-1002. 2011
    ..43). These results suggest that a major part of the task-related changes in the oxyHb concentration in the forehead is due to task-related changes in the skin blood flow, which is under different autonomic control than heart rate...
  14. ncbi Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex
    Andrew K Dunn
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 27:279-90. 2005
    ..Multi-parameter full field imaging of the functional response provides a more complete picture of the hemodynamic response to functional activation including the spatial and temporal estimation of CMRO(2) changes...
  15. ncbi The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics
    D A Boas
    NMR Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Neuroimage 13:76-90. 2001
    ..For the standard NIRS analysis to become more accurate for focal changes, it must account for the position of the focal change relative to the source and detector as well as the wavelength dependent optical properties of the medium...
  16. ncbi Noninvasive evaluation of intrarenal oxygenation with BOLD MRI
    P V Prasad
    Department of Radiology and Medicine, Beth Israel Hospital, Boston, MA 02215, USA
    Circulation 94:3271-5. 1996
    ....
  17. ncbi Synchronization between arterial blood pressure and cerebral oxyhaemoglobin concentration investigated by wavelet cross-correlation
    A B Rowley
    Department of Engineering Science, University of Oxford, Oxford, UK
    Physiol Meas 28:161-73. 2007
    ....
  18. ncbi Sex and age dependencies of cerebral blood volume changes during cognitive activation: a multichannel near-infrared spectroscopy study
    Masaki Kameyama
    Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
    Neuroimage 22:1715-21. 2004
    ..Sex- and age-dependent differences in cerebral activation, as demonstrated in the present study, should be considered when interpreting cerebral blood volume, cerebral blood flow, and cerebral glucose metabolism data...
  19. ncbi Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion
    Karel J Zuzak
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Anal Chem 74:2021-8. 2002
    ....
  20. ncbi Practicality of wavelength selection to improve signal-to-noise ratio in near-infrared spectroscopy
    Hiroki Sato
    Advanced Research Laboratory, Hitachi, Ltd, 2520 Akanuma, Hatoyama, Saitama 350 0395, Japan
    Neuroimage 21:1554-62. 2004
    ..The improved S/N enables more sensitive statistical analysis, which is essential to functional mapping with NIRS...
  21. ncbi Minimal arterial in-flow protects renal oxygenation and function during porcine partial nephrectomy: confirmation by hyperspectral imaging
    Sara L Best
    Department of Urology, University of Texas Southwestern Medical School, Dallas, TX, USA
    Urology 78:961-6. 2011
    ..Renal ischemia during partial nephrectomy can have adverse consequences on renal function...
  22. ncbi Evaluation of a near-infrared spectrometer (NIRO 300) for the detection of intracranial oxygenation changes in the adult head
    P G Al-Rawi
    University Department of Neurosurgery, Addenbrooke's Hospital, Cambridge, UK
    Stroke 32:2492-500. 2001
    ..5% and 0%, respectively, and specificity was 100% and 0%, respectively. CONCLUSIONS: The NIRO 300 reflects changes in cerebral tissue oxygenation when TOI is calculated, with a high degree of sensitivity and specificity...
  23. pmc Spatial frequency domain imaging of port wine stain biochemical composition in response to laser therapy: a pilot study
    Amaan Mazhar
    Beckman Laser Institute, University of California, Irvine, California 92612, USA
    Lasers Surg Med 44:611-21. 2012
    ..Herein, we present a pilot study using a newly developed, light emitting diode (LED) based spatial frequency domain imaging (SFDI) device to record quantitatively biochemical compositional changes in PWS after laser therapy...
  24. ncbi Use of fNIRS to assess resting state functional connectivity
    Chun Ming Lu
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, PR China
    J Neurosci Methods 186:242-9. 2010
    ..The potential influence of a specific low-frequency filtering range (0.04-0.15 Hz and 0.01-0.08 Hz) and three fNIRS parameters (oxy-Hb, deoxy-Hb, and total-Hb) on RSFC results were also examined...
  25. ncbi Caffeine stimulates ventilation in athletes with exercise-induced hypoxemia
    Robert F Chapman
    Human Performance Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA
    Med Sci Sports Exerc 40:1080-6. 2008
    ....
  26. ncbi The effect of resistive breathing on leg muscle oxygenation using near-infrared spectroscopy during exercise in men
    John M Kowalchuk
    Department of Physiology, St George s Hospital Medical School, Cranmer Terrance, Tooting, London SW17 0RE, UK
    Exp Physiol 87:601-11. 2002
    ..Assuming that leg muscle O2 consumption did not decrease, this implies that leg blood flow was not reduced consequent to a redistribution of flow away from the working leg muscle...
  27. ncbi Wavelength dependence of the precision of noninvasive optical measurement of oxy-, deoxy-, and total-hemoglobin concentration
    Y Yamashita
    Hitachi, Ltd, Advanced Research Laboratory, Hatoyama, Saitama, 350 0395
    Med Phys 28:1108-14. 2001
    ..The measurement of the concentration changes made using an 830/664-nm pair are two times (oxy-Hb) and six times (deoxy-Hb) more precise than those made using an 830/782-nm pair...
  28. ncbi Near-infrared spectroscopy: does it function in functional activation studies of the adult brain?
    H Obrig
    Department of Neurology, Charite, Humboldt Universitat zu Berlin, 10098, Berlin, Germany
    Int J Psychophysiol 35:125-42. 2000
    ..Some of the work described here has been published elsewhere...
  29. pmc Determination of optical properties of turbid media spanning visible and near-infrared regimes via spatially modulated quantitative spectroscopy
    Rolf B Saager
    University of California Irvine, Beckman Laser Institute, Irvine, California 92612, USA mail
    J Biomed Opt 15:017012. 2010
    ..The resultant absorption spectrum was well described by a multichromophore fit, and the quantitative values for oxy- and deoxyhemoglobin, water, and melanin were within published ranges for skin...
  30. ncbi Assessment of renal oxygenation during partial nephrectomy using hyperspectral imaging
    Michael S Holzer
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Urol 186:400-4. 2011
    ..We describe our initial experience using hyperspectral imaging to assess renal hemoglobin saturation parameters during open partial nephrectomy for renal cortical tumors in humans...
  31. ncbi Absolute quantification of oxygenated hemoglobin within the visual cortex with functional near infrared spectroscopy (fNIRS)
    Michelle A McIntosh
    Department of Vision Sciences, Glasgow Caledonian University, Glasgow, United Kingdom
    Invest Ophthalmol Vis Sci 51:4856-60. 2010
    ..To examine absolute changes in oxygenated (HbO) and deoxygenated (Hb) hemoglobin concentrations over the visual cortex in response to visual stimulation. Before this study, only relative changes have been reported at the visual cortex...
  32. ncbi The limitations of near-infrared spectroscopy to assess cerebrovascular reactivity: the role of slow frequency oscillations
    Jennifer Diedler
    Academic Neurosurgical Unit, University of Cambridge Clinical School, Cambridge, United Kingdom
    Anesth Analg 113:849-57. 2011
    ..In the current study, we investigated the role of slow oscillations of total hemoglobin for NIRS-based cerebrovascular reactivity monitoring...
  33. ncbi Effect of 2,3-diphosphoglycerate on O2-dissociation kinetics of hemoglobin and glycosylated hemoglobin using the stopped flow technique and an improved in vitro method for hemoglobin glycosylation
    J P Marschner
    Department of Clinical Pharmacology, University Hospital, Frankfurt Main
    Int J Clin Pharmacol Ther 32:116-21. 1994
    ....
  34. ncbi Brain activation in elderly people with and without dementia: Influences of gender and medication
    Melany M Richter
    Laboratory of Psychophysiology and Functional Imaging, University Hospital of Psychiatry and Psychotherapy, Wuerzburg, Germany
    World J Biol Psychiatry 8:23-9. 2007
    ..In HHb, evidence for an entrainment effect was found. In the light of existing literature, the present study suggests an interaction of gender and age regarding brain activation patterns which should be aimed at in future investigations...
  35. ncbi Simultaneous near-infrared spectroscopy monitoring of left and right occipital areas reveals contra-lateral hemodynamic changes upon hemi-field paradigm
    W N Colier
    Department of Physiology 237, University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Vision Res 41:97-102. 2001
    ....
  36. ncbi Functional near-infrared optical imaging: utility and limitations in human brain mapping
    Yoko Hoshi
    Department of Integrated Neuroscience, Tokyo Institute of Psychiatry, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    Psychophysiology 40:511-20. 2003
    ....
  37. ncbi Frontal lobe function in bipolar disorder: a multichannel near-infrared spectroscopy study
    Masaki Kameyama
    Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi shi, Gunma 371 8511, Japan
    Neuroimage 29:172-84. 2006
    ..Bipolar disorder and major depression were characterized by preserved but delayed and reduced frontal lobe activations, respectively, in the present high-time-resolution study by multichannel NIRS...
  38. ncbi Age dependency of the hemodynamic response as measured by functional near-infrared spectroscopy
    Matthias L Schroeter
    Max Planck Institute of Cognitive Neuroscience, Stephanstrasse 1a, 04103 Leipzig, Germany
    Neuroimage 19:555-64. 2003
    ..In summary, our findings suggest that aging decreases the hemodynamic response in the frontal association cortex during functional activation, omitting the primary motor cortex...
  39. ncbi Cerebral blood oxygenation changes induced by auditory stimulation in newborn infants measured by near infrared spectroscopy
    K Sakatani
    Department of Neurosurgery, China Japan Friendship Hospital, Hepingli, Beijing, People s Republic of China
    Early Hum Dev 55:229-36. 1999
    ..These results support the hypothesis that increments in O2 consumption exceed increments in O2 delivery during neuronal activity in newborns...
  40. ncbi Functional frequency-domain near-infrared spectroscopy detects fast neuronal signal in the motor cortex
    Martin Wolf
    Laboratory for Fluorescence Dynamics, Department of Physics, University of Illinois at Urbana Champaign, 61801 3080, USA
    Neuroimage 17:1868-75. 2002
    ..6. The advantage of this noninvasive technique with respect to electrical recording is that it is able to detect neuronal activity with the relatively high spatial resolution of 8 mm...
  41. ncbi Removal of the skin blood flow artifact in functional near-infrared spectroscopic imaging data through independent component analysis
    Satoru Kohno
    Shimadzu Corporation, Medical Systems Division, Research and Development Department, Kyoto 604 8511, Japan
    J Biomed Opt 12:062111. 2007
    ..The coefficient of correlation indicates strong correlation. Localized activation areas around the premotor and medial somatosensory cortices are shown more clearly by eliminating the extracted component...
  42. ncbi Effects of skin pigmentation on pulse oximeter accuracy at low saturation
    Philip E Bickler
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Anesthesiology 102:715-9. 2005
    ..It is uncertain whether skin pigmentation affects pulse oximeter accuracy at low HbO2 saturation...
  43. ncbi Simultaneous measurement of cerebral tissue oxygenation over the adult frontal and motor cortex during rest and functional activation
    Terence S Leung
    Department of Medical Physics and Bioengineering, University College London, London, WC1E 6JA, UK
    Adv Exp Med Biol 510:385-9. 2003
  44. ncbi The influence of a clear layer on near-infrared spectrophotometry measurements using a liquid neonatal head phantom
    M Wolf
    Clinic for Neonatology, University Hospital, Zurich, Switzerland
    Phys Med Biol 44:1743-53. 1999
    ..3, 29.2, 23.4 and 16.6%. Concentration changes were underestimated by a factor of six to ten. This study demonstrates the need to develop algorithms which take into consideration anatomical structures...
  45. pmc Role of the cysteine protease interpain A of Prevotella intermedia in breakdown and release of haem from haemoglobin
    Dominic P Byrne
    School of Dental Sciences, University of Liverpool, Daulby Street, Liverpool L69 3GN, UK
    Biochem J 425:257-64. 2010
    ..In summary, we conclude that InpA may play a central role in haem acquisition by mediating oxyhaemoglobin oxidation, and by degrading aquomethaemoglobin in which haem-globin affinity is weakened under acidic conditions...
  46. ncbi Dark skin decreases the accuracy of pulse oximeters at low oxygen saturation: the effects of oximeter probe type and gender
    John R Feiner
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California 94143 0648, USA
    Anesth Analg 105:S18-23, tables of contents. 2007
    ..Pulse oximetry may overestimate arterial oxyhemoglobin saturation (Sao2) at low Sao2 levels in individuals with darkly pigmented skin, but other factors, such as gender and oximeter probe type, remain less studied...
  47. ncbi Effect of probe arrangement on reproducibility of images by near-infrared topography evaluated by a virtual head phantom
    Hiroshi Kawaguchi
    Department of Electronics and Electrical Engineering, Keio University, Japan
    Appl Opt 46:1658-68. 2007
    ..The overlapping measurements by the double-density probe arrangement can improve the reproducibility of the image obtained by NIR topography...
  48. ncbi Multidistance probe arrangement to eliminate artifacts in functional near-infrared spectroscopy
    Toru Yamada
    National Institute of Advanced Industrial Science and Technology, Neuroscience Research Institute, 1 1 1 Umezono Central 2, Tsukuba, Ibaraki 305 8568, Japan
    J Biomed Opt 14:064034. 2009
    ..A statistically significant increase in oxygenated hemoglobin and decrease in deoxygenated hemoglobin are simultaneously observed at the contralateral primary motor area...
  49. pmc Red blood cell magnetophoresis
    Maciej Zborowski
    Department of Biomedical Engineering ND20, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44915, USA
    Biophys J 84:2638-45. 2003
    ..Magnetophoresis may open up an approach to characterize and separate cells for biochemical analysis based on intrinsic and extrinsic magnetic properties of biological macromolecules...
  50. ncbi Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation
    Andrew M Siegel
    Tufts University Bioengineering Center, Medford, MA 02155, USA
    Phys Med Biol 48:1391-403. 2003
    ....
  51. ncbi Noninvasive optical imaging in the visual cortex in young infants
    Takashi Kusaka
    Maternal Perinatal Center, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Hum Brain Mapp 22:122-32. 2004
    ..Our results demonstrated that regional hemodynamic change could be detected in a small area around the visual cortex. MNIRS offers considerable potential for research and noninvasive clinical applications...
  52. ncbi Characterization of renal ischemia using DLP hyperspectral imaging: a pilot study comparing artery-only occlusion versus artery and vein occlusion
    Chad R Tracy
    University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    J Endourol 24:321-5. 2010
    ....
  53. pmc Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging
    Maria Angela Franceschini
    NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Psychophysiology 40:548-60. 2003
    ..Our findings based on optical imaging are in agreement with results in the literature obtained with positron emission tomography and functional magnetic resonance imaging...
  54. ncbi The oxygenation response to functional stimulation: is there a physiological meaning to the lag between parameters?
    S Boden
    Berlin NeuroImaging Center, Chariteplatz 1, 10098 Berlin, Germany
    Neuroimage 36:100-7. 2007
    ..These data shed some doubt on the alleged fundamental physiological difference between cortical hemodynamic regulation in motor and visual cortex and highlight the relevance to respect contributions of the systemic hemodynamics...
  55. pmc A combination of both arginine- and lysine-specific gingipain activity of Porphyromonas gingivalis is necessary for the generation of the micro-oxo bishaem-containing pigment from haemoglobin
    John W Smalley
    Unit of Basic Dental Science, Department of Clinical Dental Sciences, University of Liverpool, The Edwards Building, Daulby Street, Liverpool L69 3GN, UK
    Biochem J 379:833-40. 2004
    ..These results show that one or both of RgpA and RgpB gingipains, in addition to the lysine-specific gingipain, is necessary for the production of mu-oxo bishaem from haemoglobin by whole cells of P. gingivalis...
  56. ncbi Activation of the prefrontal cortex to trauma-related stimuli measured by near-infrared spectroscopy in posttraumatic stress disorder due to terrorism
    Koji Matsuo
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Psychophysiology 40:492-500. 2003
    ..Significantly enhanced SCR was also observed in the victims with PTSD during trauma-related stimuli. The findings suggest that measurement of cerebral hemodynamic response by NIRS is useful for psychophysiological assessment of PTSD...
  57. ncbi Hemichrome formation observed in human haemoglobin A under various buffer conditions
    Y Sugawara
    Department of Health Science, Hiroshima Prefectural Women s University, Health Science, Hiroshima, Japan
    Acta Physiol Scand 179:49-59. 2003
    ..To observe hemichrome formation in human haemoglobin A under various buffer conditions...
  58. ncbi Prefrontal cortical involvement in young infants' analysis of novelty
    Tamami Nakano
    Department of Physical and Health Education, Graduate School of Education, University of Tokyo, Tokyo 113 0033, Japan
    Cereb Cortex 19:455-63. 2009
    ....
  59. ncbi Hemodynamic responses to visual stimulation in occipital and frontal cortex of newborn infants: a near-infrared optical topography study
    Gentaro Taga
    Graduate School of Education, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
    Early Hum Dev 75:S203-10. 2003
    ..These results suggest that the cerebrovascular coupling is already functioning in newborn's brain. The prefrontal activation implies that it may contribute to early processing of sensory signals...
  60. ncbi The right hemisphere of sleeping infant perceives sentential prosody
    Fumitaka Homae
    Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Agency, Kawaguchi Center Building, Kawaguchi shi, Saitama
    Neurosci Res 54:276-80. 2006
    ..Our findings suggest that prosodic processing in the right hemisphere may facilitate the acquisition of lexical or syntactic knowledge in the early stages of language development...
  61. ncbi The impact of the Micro-Lightguide O2C for the quantification of tissue ischemia in diabetic foot ulcers
    Stefan Beckert
    Department of General Surgery, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    Diabetes Care 27:2863-7. 2004
    ..This study investigates the impact of the tissue O2 analysis system "O2C" for noninvasive quantification of tissue oxygenation in diabetic foot ulcer patients...
  62. ncbi Sequential action of R- and K-specific gingipains of Porphyromonas gingivalis in the generation of the haem-containing pigment from oxyhaemoglobin
    John W Smalley
    Department of Clinical Dental Sciences, The University of Liverpool, Liverpool, UK
    Arch Biochem Biophys 465:44-9. 2007
    ..W. Smalley, M.F. Thomas, A.J. Birss, R. Withnall, J. Silver, Biochem. J. 379 (2004) 833-840.] of the requirement for a combination of both R- and K-gingipains for pigment production from oxyhaemoglobin by P. gingivalis...
  63. ncbi Parameters of postocclusive reactive hyperemia measured by near infrared spectroscopy in patients with peripheral vascular disease and in healthy volunteers
    R Kragelj
    University of Ljubljana, Faculty of Electrical Engineering, Slovenia
    Ann Biomed Eng 29:311-20. 2001
    ..Although longer time parameters of reactive hyperemia and lower rates of hyperemic response were detected, the difference between both groups was not statistically significant...
  64. ncbi Prefrontal brain activation during stop-signal response inhibition: an event-related functional near-infrared spectroscopy study
    Maren Boecker
    Department of Medical Psychology and Medical Sociology, University Hospital Aachen, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Behav Brain Res 176:259-66. 2007
    ..The findings indicate that NIRS is suitable for the functional identification of prefrontal activation during the inhibition of initiated responses and provide further support for the contribution of the PFC to response inhibition...
  65. pmc Interactions of Porphyromonas gingivalis with oxyhaemoglobin and deoxyhaemoglobin
    John W Smalley
    Unit of Oral Biology, The Edwards Building, Department of Clinical Dental Sciences, University of Liverpool, Daulby Street, Liverpool L69 3GN, U K
    Biochem J 362:239-45. 2002
    ..Interaction of cells with deoxyhaemoglobin resulted in formation of an iron(III) haem species (Soret gamma(max), 393 nm), identified as pure mu-oxo bishaem...
  66. ncbi Age estimation of blood stains by hemoglobin derivative determination using reflectance spectroscopy
    Rolf H Bremmer
    Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Forensic Sci Int 206:166-71. 2011
    ..In conclusion, we propose that the results obtained under controlled conditions demand further evaluation of their possible value for age determination of blood stains on crime scenes...
  67. ncbi Reduced frontopolar activation during verbal fluency task in schizophrenia: a multi-channel near-infrared spectroscopy study
    Ryu Takizawa
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Schizophr Res 99:250-62. 2008
    ....
  68. ncbi Decreased prefrontal activation during letter fluency task in adults with pervasive developmental disorders: a near-infrared spectroscopy study
    Hitoshi Kuwabara
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Behav Brain Res 172:272-7. 2006
    ..The present results may be also potentially useful for applying NIRS to clinical settings of child psychiatry...
  69. ncbi Synchronization between background activity and visually evoked potential is not mirrored by focal hyperoxygenation: implications for the interpretation of vascular brain imaging
    Stefan P Koch
    Berlin NeuroImaging Centre, Department of Neurology, Charite Universitatsmedizin Berlin, 10117 Berlin, Germany
    J Neurosci 26:4940-8. 2006
    ....
  70. ncbi Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study
    Naresh M Punjabi
    Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD21224, USA
    Am J Epidemiol 160:521-30. 2004
    ..The results of this study suggest that SDB is independently associated with glucose intolerance and insulin resistance and may lead to type 2 diabetes mellitus...
  71. ncbi Relationship of arousals from sleep to sympathetic nervous system activity and BP in obstructive sleep apnea
    J S Loredo
    Department of Medicine, University of California, San Diego, USA
    Chest 116:655-9. 1999
    ..Obstructive sleep apnea (OSA) patients have a high frequency of arousals. We hypothesized that arousals significantly influence tonic sympathetic nervous system function...
  72. ncbi Functional MR imaging: comparison of BOLD signal intensity changes in fetal organs with fetal and maternal oxyhemoglobin saturation during hypoxia in sheep
    Ulrike Wedegärtner
    Department of Diagnostic and Interventional Radiology, University Medical Center, Hamburg Eppendorf, Germany
    Radiology 238:872-80. 2006
    ..To compare relative changes in blood oxygen level-dependent (BOLD) signal intensity in the fetal brain, liver, heart, lungs, and cotyledon with maternal and fetal blood oxygenation during maternal hypoxia in sheep...
  73. ncbi Prefrontal cerebral blood volume patterns while playing video games--a near-infrared spectroscopy study
    Shinichiro Nagamitsu
    Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi machi Kurume City, Fukuoka 830 0011, Japan
    Brain Dev 28:315-21. 2006
    ....
  74. pmc Dynamic physiological modeling for functional diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 30:88-101. 2006
    ..This state-space approach to DOT analysis could be extended to BOLD fMRI analysis, multimodal studies and real-time analysis...
  75. ncbi Motor imagery in response to fake feedback measured by functional near-infrared spectroscopy
    Lisa Holper
    Biomedical Optics Research Laboratory, Clinic of Neonatology, University Hospital Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland
    Neuroimage 50:190-7. 2010
    ..We present fNIRS data of MI performance in response to different feedback conditions indicating that there exist distinct oxygenation patterns. These data may contribute to the development of fNIRS controlled feedback systems...
  76. ncbi Near-infrared spectroscopy analysis of frontal lobe dysfunction in schizophrenia
    Toshikazu Shinba
    Department of Stress Disorders Research and Integrative Neuroscience, Tokyo Institute of Psychiatry, Tokyo, Japan
    Biol Psychiatry 55:154-64. 2004
    ..In the present study, frontal function in schizophrenic patients was analyzed by NIRS during random number generation (RNG), ruler-catching (RC), and sequential finger-to-thumb (SFT) tasks...
  77. ncbi Bedside functional imaging of the premature infant brain during passive motor activation
    S R Hintz
    Biomedical Optics Group, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Hansen Physics Laboratory, Palo Alto, California, USA
    J Perinat Med 29:335-43. 2001
    ..Imaging methods, which use near-infrared light allow for non-invasive measurements by taking advantage of the fact that hemoglobin is a strong absorber at these wavelengths...
  78. ncbi Transcutaneous near-infrared spectroscopy for detection of regional spinal ischemia during intercostal artery ligation: preliminary experimental results
    Scott A LeMaire
    Cardiovascular Surgery Service, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Tex, USA
    J Thorac Cardiovasc Surg 132:1150-5. 2006
    ..We hypothesized that near-infrared spectroscopy could provide such information during intercostal and lumbar artery ligation in pigs...
  79. ncbi Changes of cerebral blood oxygenation and optical pathlength during activation and deactivation in the prefrontal cortex measured by time-resolved near infrared spectroscopy
    Kaoru Sakatani
    Department of Neurological Surgery, Nihon University School of Medicine, Japan
    Life Sci 78:2734-41. 2006
    ..The present results will be useful for quantitative measurement of hemodynamic changes during activation and deactivation in the adults by near infrared spectroscopy...
  80. ncbi Near-infrared spectroscopy and imaging of tumor vascular oxygenation
    Hanli Liu
    Biomedical Engineering Program, The University of Texas at Arlington, 76019, USA
    Methods Enzymol 386:349-78. 2004
  81. ncbi Maintained cerebral and skeletal muscle oxygenation during maximal exercise in patients with liver cirrhosis
    Henning Bay Nielsen
    Department of Hepatology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 København O, Denmark
    J Hepatol 43:266-71. 2005
    ..In cirrhotic patients, insufficient redistribution of blood from splanchnic organs to the central circulation could limit blood supply to skeletal muscles and the brain during exercise...
  82. ncbi Effects of assuming constant optical scattering on measurements of muscle oxygenation by near-infrared spectroscopy during exercise
    Leonardo F Ferreira
    Department of Kinesiology, Kansas State University, Manhattan, KS 66506 0302, USA
    J Appl Physiol 102:358-67. 2007
    ..8 s. In conclusion, mu'(s) changed from light to peak exercise. Furthermore, assuming a constant mu'(s) led to an overestimation of the changes in NIRS variables during exercise and distortion of the recovery kinetics...
  83. ncbi Effects of cerebral ischemia on evoked cerebral blood oxygenation responses and BOLD contrast functional MRI in stroke patients
    Yoshihiro Murata
    Department of Neurosurgery, Nihon University School of Medicine, 30 1, Oyaguchi Kamimachi, Itabashi ku, Tokyo 173 8610, Japan
    Stroke 37:2514-20. 2006
    ....
  84. ncbi Evoked-cerebral blood oxygenation changes in false-negative activations in BOLD contrast functional MRI of patients with brain tumors
    Norio Fujiwara
    Department of Neurosurgery, Nihon University School of Medicine, Tokyo, Japan
    Neuroimage 21:1464-71. 2004
    ..e. increases in Deoxy-Hb) and the software employed to calculate the activation maps, which does not regard an increase of Deoxy-Hb (i.e., a decrease in BOLD-fMRI signal) as neuronal activation...
  85. ncbi Changes in masseteric hemodynamics time-related to mental stress
    O Hidaka
    Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Dent Res 83:185-90. 2004
    ..These results suggest that mental stress induces hemodynamic changes that are not associated with EMG activity in the masseter muscle of healthy adult females...
  86. ncbi Electrostimulation improves muscle perfusion but does not affect either muscle deoxygenation or pulmonary oxygen consumption kinetics during a heavy constant-load exercise
    Gwenael Layec
    Faculte de Medecine de Marseille, Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, 27 Bd Jean Moulin, 13005, Marseille, France
    Eur J Appl Physiol 102:289-97. 2008
    ..These results suggest that improved O(2) delivery by residual hyperaemia induced by EMS does not accelerate the rate of aerobic metabolism during heavy exercise at least in trained subjects...
  87. ncbi Near-infrared spectroscopy in evaluation of cerebral oxygenation during vasovagal syncope
    E Szufladowicz
    National Institute of Cardiology, Alpejska 42, 04 628 Warsaw, Poland
    Physiol Meas 25:823-36. 2004
    ..3 min before the syncope. They preceded the presyncope symptoms about 1.3 min (p < 0.005), the blood pressure and heart rate drop 2.2 min (p < 0.0001) and the arterial blood saturation 2.6 min (p < 0.00001)...
  88. ncbi Activation of the prefrontal cortex during memory learning: near-infrared spectroscopy study
    Mie Matsui
    Department of Neuropsychiatry and Neuropsychology, Graduate School of Medicine, University of Toyama, Sugitani, Toyama, Japan
    Psychiatry Clin Neurosci 61:31-8. 2007
    ..There were no significant relationships between the behavior indices and the changes in hemoglobin. Further studies are needed to clarify usefulness of NIRS in patients with psychiatric disorder...
  89. ncbi In vitro measurements of absolute blood oxygen saturation using pulsed near-infrared photoacoustic spectroscopy: accuracy and resolution
    Jan Laufer
    Department of Medical Physics and Bioengineering, University College London, Malet Place Engineering Building, London WC1E 6BT, UK
    Phys Med Biol 50:4409-28. 2005
    ..5% SO2 for effective attenuation spectra. The smallest change in oxygen saturation that can be measured using this technique was +/-1% SO2...
  90. ncbi Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia
    Sonoko Ijichi
    Kagawa University, Department of Pediatrics, Faculty of Medicine, Mikicho 1750 1, Kitagun, Kagawa 761 0793, Japan
    J Biomed Opt 10:024026. 2005
    ..Therefore, abs of the head with BET by FC is more useful for estimation of the absolute values of oxyHb and deoxyHb of the piglet head...
  91. ncbi Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study
    Valentina Quaresima
    University of L Aquila, Department of Biomedical Sciences and Technologies, I 67100 L Aquila, Italy
    J Biomed Opt 10:11012. 2005
    ..1+/-0.5%) compared to left side of the prefrontal cortex (0.9+/-0.5%) (P=0.005). A different pattern of cortical activation (characterized by the lack of HHb decrease or even increased HHb) was observed in the remaining subjects...
  92. ncbi Brain cell function during hypoxemia in near-term lambs: a near-infrared spectroscopy study
    Sandra van Os
    Division of Neonatology, Department of Pediatrics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Biol Neonate 88:79-86. 2005
    ..Sufficient O2 supply to the brain is necessary for adequate cerebral energy metabolism, function and growth...
  93. ncbi Detection of cerebral oxyhaemoglobin changes during vestibular Coriolis cross-coupling stimulation using near infrared spectroscopy
    A Kobayashi
    Pharmacochemistry Section, Aeromedical Laboratory, Japan Air Self Defense Force, Tachikawa shi, Tokyo
    Neurosci Lett 394:83-7. 2006
    ..NIRS can be used to monitor discrete cortical blood flow changes resulting from vestibular and other forms of stimulation...
  94. ncbi Hemodilutional anemia impairs neurologic outcome after cardiopulmonary bypass in a piglet model
    Takashi Miura
    Terumo Medical Pranex, Kanagawa, Japan
    J Thorac Cardiovasc Surg 133:29-36. 2007
    ..The effect of hemodilution on neurologic outcome after cardiopulmonary bypass remains unclear. We studied the influences of hematocrit on cerebral oxygenation and neuropathologic outcome in a piglet model...
  95. ncbi Reduced prefrontal oxygenation in Alzheimer disease during verbal fluency tasks
    Martin J Herrmann
    University Hospital of Psychiatry and Psychotherapy, University of Wurzburg, Germany
    Am J Geriatr Psychiatry 16:125-35. 2008
    ..As previous research suggested changes in functional brain activation in prefrontal brain areas of patients with dementia, the aim of this study was to replicate these findings by means of multichannel NIRS...
  96. ncbi Transabdominal fetal pulse oximetry with near-infrared spectroscopy
    Anthony M Vintzileos
    Department of Obstetrics, Gynecology and Reproductive Sciences, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Am J Obstet Gynecol 192:129-33. 2005
    ..The purpose of this study was to determine the feasibility of noninvasive fetal pulse oximetry in the human fetus with transabdominal continuous-wave near-infrared spectroscopy...
  97. ncbi Effect of muscle tensing on cerebral oxygen status during sustained high +Gz
    Asao Kobayashi
    Pharmacochemistry Section, Aeromedical Laboratory, Japan Air Self Defense Force, Tokyo
    Aviat Space Environ Med 73:597-600. 2002
    ..To assess the effects of muscle tensing on sustained +Gz tolerance, we measured muscle activity and cerebral oxygen status (COS) during anti-G straining maneuvers at sustained high +Gz...
  98. ncbi Clinical evaluation of time-resolved spectroscopy by measuring cerebral hemodynamics during cardiopulmonary bypass surgery
    Etsuko Ohmae
    Hamamatsu Photonics K K, Central Research Laboratory, 5000 Hirakuchi, Hamamatsu, Shizuoka, 434 8601, Japan
    J Biomed Opt 12:062112. 2007
    ..Moreover, there was a good correlation between tHb and Hct values (r(2)=0.63). We concluded that time-resolved spectroscopy reflected the conditions of cerebral hemodynamics of patients during surgical operations...
  99. ncbi Near-infrared spectroscopy (NIRS): a non-invasive in vivo methodology for analysis of brain vascular and metabolic activities in real time in rodents
    Francesco Crespi
    Biology, Psychiatry CEDD, GlaxoSmithKline, Via Fleming 4, Verona, Italy
    Curr Vasc Pharmacol 5:305-21. 2007
    ..The data gathered in rat treated with exogenous O(2), indicate an original relationship between NIRS analysis of brain metabolism and electrical changes in this major nucleus of CNS involved in neurophysiologic and pathologic activities...
  100. ncbi Multimodal investigation of fMRI and fNIRS derived breath hold BOLD signals with an expanded balloon model
    U E Emir
    Institute of Biomedical Engineering, Bogazici University, 34342 Bebek Istanbul, Turkey
    Physiol Meas 29:49-63. 2008
    ..In conclusion, a multimodal approach with an appropriate biophysical model gave a comprehensive description of the hemodynamic response during BHT...
  101. ncbi Near infrared and visible spectroscopic measurements to detect changes in light scattering and hemoglobin oxygen saturation from rat spinal cord during peripheral stimulation
    Hanli Liu
    Joint Graduate Program of Biomedical Engineering, University of Texas at Arlington UT Southwestern Medical Center at Dallas, Arlington, TX 76019, USA
    Neuroimage 40:217-27. 2008
    ....

Research Grants63

  1. Real-Time Optical Diagnosis of Inflammatory Bowel Disease using SFDI
    Sylvain Gioux; Fiscal Year: 2013
    ....
  2. Soluble guanylyl cyclase modulation by endogenous elements and exogenous factors
    Emil Martin; Fiscal Year: 2012
    ..Understanding the mechanisms governing sGC function (ligand selectivity, enzyme activation or deactivation) is essential for improving existing regimens and developing new sGC-directed therapies. ..
  3. Real-Time Flap Viability Monitoring during Facial Transplantation using SFDI
    BERNARD TRAVIS LEE; Fiscal Year: 2013
    ....
  4. Cerebral artery Ca2+ signaling & subarachnoid hemorrhage
    George Wellman; Fiscal Year: 2009
    ..This study should significantly enhance current knowledge with respect to Ca2+signaling and constriction of cerebral arteries in health and disease and provide insight into possible new therapies for the treatment of cerebral vasospasm. ..
  5. Rapid, noninvasive diagnosis and monitoring of shock
    DONALD SANDERSON PROUGH; Fiscal Year: 2010
    ..The proposed optoacoustic system will replace invasive, intermittent diagnostic testing of central venous blood oxygenation hemoglobin with noninvasive, rapid, and continuous monitoring. ..
  6. The development of novel peptidic and peptidomimetic therapies for the treatment
    BRIAN BUERK BRENNAN; Fiscal Year: 2012
    ..The research proposed is the first step in defining the feasibility of a new strategy for treating this disorder through the use of modern screening and selection techniques. ..
  7. Noninvasive Functional and Cellular Imaging of Epilepsy
    Huabei Jiang; Fiscal Year: 2013
    ..Both technological development and in vivo animal studies are proposed in this application. ..
  8. Neurocognitive Function and Cerebral Perfusion in Cardiac Surgery
    Daniel C Lee; Fiscal Year: 2011
    ..The information gathered will help surgeons and anesthesiologists manage patients appropriately to prevent neurological complications. ..
  9. SoundTrak: A Data Acquisition and Analysis System for OSDB
    B Parker; Fiscal Year: 2009
    ..This decision underscores the relevance of the project and the viability of the marketplace. ..
  10. High resolution functional MRI of columnar structures
    Ravi Menon; Fiscal Year: 2007
    ..The concentrations of oxyhemoglobin [HbO] and deoxyhemoglobin [Hbr] will also be measured using NIR spectroscopy (NIRS). Blood flow will be measured using a commercial fiber optic laser Doppler flow system (Oxyflow, Oxford Optronix). ..
  11. AUTO-ANALYZER FOR FIVE HEMOGLOBIN SPECIES AND BILIRUBIN
    JOHN STEINKE; Fiscal Year: 1992
    ..Steinke's device. Light from this source will be sequentially passed through seven filters, each of which will eliminate all wavelengths except the one assigned to that filter...
  12. MEASURING QOL DURING TREATMENT FOR SLEEP APNEA
    JEANNETTE BREUGELMANS; Fiscal Year: 2000
    ..abstract_text> ..
  13. Role of astroglia in cocaine-induced neurotoxicity
    Helene Benveniste; Fiscal Year: 2009
    ....
  14. Cerebral Microvascular Endothelin Production
    Momoh Yakubu; Fiscal Year: 2003
    ..Our understanding of the mechanisms underlying the consequences of SAH will make it possible for early and appropriate intervention to prevent or reduce these complications from hemorrhagic stroke. ..
  15. NONINVASIC OPTICAL SENSOR FOR HEMOGLOBIN MEASUREMENTS
    LEONARD WINCHESTER; Fiscal Year: 1999
    ..This type of instrumentation clearly has commercial potential and should be of interest to an assortment of health care providers. PROPOSED COMMERCIAL APPLICATION: Not available. ..
  16. DIABETIC KETOACIDOSIS: ALTERATIONS IN MINERAL METABOLISM
    Joseph Fisher; Fiscal Year: 1980
    ..During the next grant year, it is anticipated that a sufficient number of additional subjects will be investigated to determine if there is statistical significance in these observations. ..
  17. CEREBRAL OXYGENATION MONITOR
    Stephen Walker; Fiscal Year: 2001
    ..PROPOSED COMMERCIAL APPLICATIONS: Market research shows over 80% of birthing sites in the US will acquire a noninvasive, intrauterine fetal cerebral oxygenation monitor if it costs less than $1,000. ..
  18. OXYGEN AFFINITY AND OXYGEN TRANSPORT IN STRIATED MUSCLE
    Mary Ellsworth; Fiscal Year: 1992
    ..In addition, these studies should provide useful information on the relationship between the coincident clinical observations of an impairment of peripheral oxygen utilization and altered hemoglobin oxygen affinity...
  19. ENDOGENOUS CO AND O2 TRANSFER IN PREGNANCY HYPERTENSION
    STEPHEN ENTMAN; Fiscal Year: 1990
    ..Finally, the project will test the hypothesis that maternal hyperoxygenation can effectively reverse this process, displace CO from maternal and fetal hemoglobin, shifting P50 to the right and thus reverse fetal stress/distress...
  20. Respiratory Peridocity and Cognitive Decline in Elders
    Barbara Carlson; Fiscal Year: 2006
    ..abstract_text> ..
  21. NEONATAL OPTICAL NON-INVASIVE BRAIN OXYGENATION MONITOR
    PAUL BENNI; Fiscal Year: 2002
    ..5% in the first year [27]. NIRS offers improved capability in neonatal monitoring to assist physicians in the care of several hundred thousand neonates and infants a year. ..
  22. NEONATAL OPTICAL NON-INVASIVE BRAIN OXYGENATION MONITOR
    PAUL BENNI; Fiscal Year: 2000
    ..5% in the first year [27]. NlRS offers improved capability in neonatal monitoring to assist physicians in the care of several hundred thousand neonates and infants a year. ..
  23. Diagnostic Imaging of Blood in Breast Tumor Angiogenesis
    Alexander Oraevsky; Fiscal Year: 2004
    ....
  24. Anti-apoptosis as a new therapy for cerebral vasospasm
    John Zhang; Fiscal Year: 2005
    ..We expect that our results will ultimately identify potential therapeutic targets of the apoptosis pathway that can be directed towards the treatment of cerebral vasospasm after SAH. ..
  25. MRI-Compatible Diffuse Optical Tomography System
    ANDREAS HIELSCHER; Fiscal Year: 2005
    ..This comparison will quantify the advantages and disadvantages of these different optical imaging modalities. ..
  26. The Dynamics of Nitric Oxide in the Vascular System
    Jack Lancaster; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  27. fMRI BOLD contrast relationship to cerebrovascular tone
    Todd Parrish; Fiscal Year: 2006
    ..The theme of this proposal is to investigate the impact of physiologic mechanisms (reactivity, flow, hematocrit, neuronal activity) on the generation of BOLD signal and more importantly BOLD contrast. ..
  28. STUDIES OF SURVIVORS OF PREHOSPITAL CARDIAC ARREST
    Robert Myerburg; Fiscal Year: 1980
    ..Similar short-term (8 hours) studies are being carried out to determine the relationship between diurnal variations in frequency of arrhythmias and corresponding fluctuations in blood levels of antiarrhythmic agents...
  29. MASS TRANSFER IN THE MICROCIRCULATION
    J Hellums; Fiscal Year: 1991
    ..Direct determination of hemoglobin saturation changes will be made in red cell suspensions flowing in the capillaries. Measurements of heme absorbance will be used to monitor oxygen transport over a wide range of conditions...
  30. OPTICAL IMAGING DEVICE OF THE RETINAL FUNCTION
    Peter Soliz; Fiscal Year: 2000
    ..Kestrel is introducing innovative applications of optical functional imaging technologies and methodologies that could improve the diagnosis of glaucoma. ..
  31. CAPILLARY-TUBE HEMOGLOBINOMETER-OXIMETER
    JOHN STEINKE; Fiscal Year: 1991
    ..If the proposed investigation is successful, the envisaged portable oximeter-hemoglobinometer could compete successfully for an enormous market-hospitals and doctor's offices worldwide...
  32. Expression of Sleep Disordered Breathing in Inbred
    ARNON RUBIN; Fiscal Year: 2002
    ..We anticipate these studies will provide unique insights not possible in human studies, and lead to a better understanding of how genetic determinants of respiratory control contribute to the expression of SDB. ..
  33. OPTICAL IMAGING DEVICE OF THE RETINAL FUNCTION
    Peter Soliz; Fiscal Year: 2003
    ..20 patients with diagnosed visual field loss due to the nerve fiber loss will be imaged and their NFL damage optically measured. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE ..
  34. Oxyhemoglobin Desaturation and Vasculopathy in SCD
    Kwaku Ohene Frempong; Fiscal Year: 2008
    ..Interventions will include clinically-indicated adenotonsillectomy, positive pressure oxygen administration, and nocturnal oxygen supplementation. ..
  35. THE SLEEP HEART HEALTH STUDY
    Naresh Punjabi; Fiscal Year: 2007
    ..Accomplishing these goals will provide important information concerning the public health impact of SDB. ..
  36. Sleep Apnea: Upper Airway Nerve Injury
    Sigrid Veasey; Fiscal Year: 2009
    ..Collectively, the proposed studies will unveil important mechanisms of neuronal injury in obstructive sleep apnea and should reveal diabetes is a risk factor for this neural injury in sleep apnea. ..
  37. DIFFERENTIAL VULNERABILITY TO MORBIDITIES OF SLEEP APNEA
    Sigrid Veasey; Fiscal Year: 2003
    ..Therefore, this work provides an essential foundation for determining gene function in the susceptibility of sleepiness, impaired cognation and behavioral responses caused by obstructive sleep apnea. (End of Abstract.) ..
  38. Auditory Information and Object Individuation in Infancy
    Teresa Wilcox; Fiscal Year: 2005
    ..These theories eventually will be used by parents, educators, and daycare providers to create environments that are most likely to facilitate learning about the physical nature of objects in healthy and at-risk infants. ..
  39. Longtitudinal Changes in Sleep Structure: Implications for Health Outcomes
    Naresh Punjabi; Fiscal Year: 2010
    ....
  40. Effects of aging on sleep architecture
    Naresh Punjabi; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  41. The Neural Basis of Object Processing in Infancy
    Teresa Wilcox; Fiscal Year: 2006
    ....
  42. EARLY IDENTIFICATION AND TREATMENT OF SLEEP APNEA
    Naresh Punjabi; Fiscal Year: 2003
    ..Punjabi the opportunity to reach his full potential as a clinical investigator. ..
  43. Effects of Nitric Oxide in Sickle Cell Blood
    DANIEL KIM SHAPIRO; Fiscal Year: 2006
    ..Our studies will help us understand important issues related to NO's role in sickle cell disease and in the general population. ..
  44. Sleep-Health & Knowledge in U.S. Hispanics
    JOSE LOREDO; Fiscal Year: 2009
    ..S. Mexican-American Hispanics should include intensive focus on Sleep Health and Sleep Health knowledge deficits. Key Words: Sleep disorders;Minority health;Epidemiology. ..
  45. Spontaneous Arousals in "CHIME" Infants at Risk for SIDS
    ROBERT DARNALL; Fiscal Year: 2006
    ..Finally, we will examine the relationships among the level of arousal, post-conceptional age, sleep state, and other infant behaviors such as feeding that are also associated with changes in autonomic activity. ..
  46. NON-INVASIVE OPTICAL IMAGING OF THE HUMAN BRAIN
    MARIA FRANCESCHINI; Fiscal Year: 2002
    ..abstract_text> ..
  47. Home-based vs. Supervised Exercise for Claudicants
    Andrew W Gardner; Fiscal Year: 2010
    ....
  48. EXERCISE FOR ELDERLY PERIPHERAL REVASCULARIZED PATIENTS
    Andrew Gardner; Fiscal Year: 2004
    ....
  49. CHEMORECEPTORS AND HYPERTENSION AND SLEEP APNEA
    JOSE LOREDO; Fiscal Year: 2003
    ..This training will provide the basis of an MPH degree and a solid theoretical background for future conduct of quality clinical research. ..
  50. PROTON RELAXATION AND CONTRAST MECHANISMS IN MRI
    John Gore; Fiscal Year: 2001
    ..This should in turn provide guidance on the interpretation of signals in conventional MR images and will motivate new approaches to tissue characterization. ..
  51. CAUSES OF SLEEP-INDUCED BREATHING INSTABILITIES
    Jerome Dempsey; Fiscal Year: 2002
    ..These latter studies conduced in sleep are important to testing the sensitivity of respiratory control mechanisms to mechanical feedback-a problem which remains relatively unexplored, especially in the human. ..
  52. Near infrared/MR system for imaging brain oxygenation
    Jeffrey Dunn; Fiscal Year: 2002
    ..This grant will produce a novel imaging modality which can non-invasively monitor cerebral oxygenation, structure, and blood flow. ..
  53. Molecular Pathophysiology of HbE Diseases
    RHODA HIRSCH; Fiscal Year: 2005
    ..abstract_text> ..
  54. Regulation of Hypoxia Inducible Factor-1 by Nitric Oxide
    Lisa Palmer; Fiscal Year: 2004
    ..At the completion of this project, we believe we will have identified several new targets for the prevention and treatment of hypoxia- induced and primary pulmonary hypertension. ..
  55. Perceiving-the-present: a general theory of illusions
    Mark Changizi; Fiscal Year: 2006
    ..Such elucidation of the function computed by the visual system is of great use, for without understanding function, one cannot make sense of the mechanisms implementing those functions in the brain. ..
  56. Instrument to Measure Oxygen Affinity of Hemoglobin
    Kim Vandegriff; Fiscal Year: 2004
    ..abstract_text> ..
  57. Pancreatic Islet Imaging and Blood Flow
    John Gore; Fiscal Year: 2005
    ..abstract_text> ..
  58. Oxygen Carriers for Hypovolemic Circulatory Collapse
    Robert Winslow; Fiscal Year: 2007
    ..The research described in this proposal will focus on molecules and formulations specifically tailored for use in prehospital and trauma settings. ..
  59. OPIOID DEPRESSION OF RESPIRATORY NEURONS
    PETER LALLEY; Fiscal Year: 2003
    ..It will also test a new method that may alleviate opioid-induced depression of respiration without affecting analgesia, and counteract respiratory depression by overdose of opioids. ..
  60. Contrast Mechanisms in Diffusion Weighted MRI
    John Gore; Fiscal Year: 2008
    ....
  61. Engineering Large scale pathways from organisms to Escherichia coli
    James Liao; Fiscal Year: 2008
    ..In particular, selected projects proposed here will be used as modules in a workshop established by FRT at Ohio State and form the basis for a course (Metabolic Engineering) at UCLA. ..
  62. Postpartum Sleep Deprivation and Fragmentation: Effects on Maternal Functioning
    HAWLEY MONTGOMERY DOWNS; Fiscal Year: 2008
    ..The study results will help researchers develop better strategies for improving the sleep of new mothers, and in turn improving their ability to function effectively. [unreadable] [unreadable] [unreadable]..
  63. MECHANISMS OF BRAIN EDEMA AFTER INTRACEREBRAL HEMORRHAGE
    Guohua Xi; Fiscal Year: 2009
    ..The purpose of our project is to investigate the mechanisms involved in thrombin-induced brain edema. If our hypotheses are correct, these experiments may lead to novel methods of treating ICH. ..