methemoglobin

Summary

Top Publications

  1. ncbi Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin
    Rozalina Grubina
    Vascular Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:12916-27. 2007
  2. ncbi Methemoglobin--it's not just blue: a concise review
    Jay Umbreit
    PPD Inc, Wilmington, North Carolina 28412, USA
    Am J Hematol 82:134-44. 2007
  3. ncbi Reduction of methemoglobin via electron transfer from photoreduced flavin: restoration of O2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles
    Hiromi Sakai
    Advanced Research Institute for Science and Engineering, Waseda University, Tokyo 169 8555, Japan
    Bioconjug Chem 15:1037-45. 2004
  4. pmc Pathway for heme uptake from human methemoglobin by the iron-regulated surface determinants system of Staphylococcus aureus
    Hui Zhu
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59718, USA
    J Biol Chem 283:18450-60. 2008
  5. pmc Synthesis, antiprotozoal, antimicrobial, β-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis(8-aminoquinolines)
    Kirandeep Kaur
    Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab 160 062, India
    Bioorg Med Chem 19:197-210. 2011
  6. pmc Shr of group A streptococcus is a new type of composite NEAT protein involved in sequestering haem from methaemoglobin
    Mahamoudou Ouattara
    Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USA
    Mol Microbiol 78:739-56. 2010
  7. pmc Functionally distinct NEAT (NEAr Transporter) domains within the Staphylococcus aureus IsdH/HarA protein extract heme from methemoglobin
    Rosemarie M Pilpa
    Department of Chemistry and Biochemistry, UCLA DOE Institute for Genomics and Proteomics, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 284:1166-76. 2009
  8. ncbi MRI of thermally denatured blood: methemoglobin formation and relaxation effects
    K Farahani
    Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, CA 90024 1721, USA
    Magn Reson Imaging 17:1489-94. 1999
  9. ncbi Pro-stimulatory role of methemoglobin in inflammation through hemin oxidation and polymerization
    Rohitas Deshmukh
    Malaria Research Group, Department of Biotechnology, Indian Institute of Technology Guwahati, Assam 781039, India
    Inflamm Allergy Drug Targets 12:68-78. 2013
  10. ncbi Plasma methemoglobin as a potential biomarker of anemic stress in humans
    Gregory M T Hare
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Can J Anaesth 59:348-56. 2012

Detail Information

Publications234 found, 100 shown here

  1. ncbi Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin
    Rozalina Grubina
    Vascular Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:12916-27. 2007
    ..reacts with deoxyhemoglobin in an allosteric reaction that generates NO and oxidizes deoxyhemoglobin to methemoglobin. NO then reacts at a nearly diffusion-limited rate with deoxyhemoglobin to form iron-nitrosyl-hemoglobin, ..
  2. ncbi Methemoglobin--it's not just blue: a concise review
    Jay Umbreit
    PPD Inc, Wilmington, North Carolina 28412, USA
    Am J Hematol 82:134-44. 2007
    ..besides carrying oxygen to the tissues, and regulates vascular tone and inflammation via a redox couple with methemoglobin. Hemoglobin has iron in the reduced valance Fe(II) and methemoglobin has iron in the oxidized valance Fe (III),..
  3. ncbi Reduction of methemoglobin via electron transfer from photoreduced flavin: restoration of O2-binding of concentrated hemoglobin solution coencapsulated in phospholipid vesicles
    Hiromi Sakai
    Advanced Research Institute for Science and Engineering, Waseda University, Tokyo 169 8555, Japan
    Bioconjug Chem 15:1037-45. 2004
    Ferric methemoglobin is reduced to its ferrous form by photoirradiation either by direct photoexcitation of the heme portion to induce electron transfer from the surrounding media (Sakai at al...
  4. pmc Pathway for heme uptake from human methemoglobin by the iron-regulated surface determinants system of Staphylococcus aureus
    Hui Zhu
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59718, USA
    J Biol Chem 283:18450-60. 2008
    ..of heme acquisition by this system, we have investigated hemin transfer between the various couples of human methemoglobin (metHb), IsdA, IsdB, IsdC, and IsdE by spectroscopic and kinetic analyses...
  5. pmc Synthesis, antiprotozoal, antimicrobial, β-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis(8-aminoquinolines)
    Kirandeep Kaur
    Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab 160 062, India
    Bioorg Med Chem 19:197-210. 2011
    ..antimicrobial (a panel of pathogenic bacteria and fungi), cytotoxicity, β-hematin inhibitory and methemoglobin (MetHb) formation activities...
  6. pmc Shr of group A streptococcus is a new type of composite NEAT protein involved in sequestering haem from methaemoglobin
    Mahamoudou Ouattara
    Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USA
    Mol Microbiol 78:739-56. 2010
    ..We suggest that Shr is the prototype of a new group of NEAT composite proteins involved in haem uptake found in pyogenic streptococci and Clostridium novyi...
  7. pmc Functionally distinct NEAT (NEAr Transporter) domains within the Staphylococcus aureus IsdH/HarA protein extract heme from methemoglobin
    Rosemarie M Pilpa
    Department of Chemistry and Biochemistry, UCLA DOE Institute for Genomics and Proteomics, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 284:1166-76. 2009
    ..We also demonstrate that the IsdC NEAT domain can capture heme directly from Hb, suggesting that there are multiple pathways for heme transfer across the cell wall...
  8. ncbi MRI of thermally denatured blood: methemoglobin formation and relaxation effects
    K Farahani
    Department of Radiological Sciences, UCLA School of Medicine, Los Angeles, CA 90024 1721, USA
    Magn Reson Imaging 17:1489-94. 1999
    ..The aims of this study were two-fold: to find evidence for heat-induced conversion of hemoglobin (Hb) to methemoglobin (mHb), and to investigate the effects of heat treatment of in-vitro blood components upon their MR relaxation ..
  9. ncbi Pro-stimulatory role of methemoglobin in inflammation through hemin oxidation and polymerization
    Rohitas Deshmukh
    Malaria Research Group, Department of Biotechnology, Indian Institute of Technology Guwahati, Assam 781039, India
    Inflamm Allergy Drug Targets 12:68-78. 2013
    ..The current study aimed to characterize the role of major pro-oxidant factor methemoglobin present in the malaria culture supernatant contributing in inflammation during malaria...
  10. ncbi Plasma methemoglobin as a potential biomarker of anemic stress in humans
    Gregory M T Hare
    Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, Canada
    Can J Anaesth 59:348-56. 2012
    ..Hemoglobin (Hb) oxidation to methemoglobin (MetHb) may be a byproduct of such local NO production...
  11. ncbi Characterization of methemoglobin formation induced by 3,5-dichloroaniline, 4-amino-2,6-dichlorophenol and 3,5-dichlorophenylhydroxylamine
    M A Valentovic
    Department of Pharmacology, Marshall University School of Medicine, Huntington, WV 25704 9388, USA
    Toxicology 118:23-36. 1997
    ..This study characterized the capacity of 3,5-dichloroaniline and two putative metabolites to induce methemoglobin formation. In vivo intraperitoneal (i.p.) administration of 0...
  12. ncbi EPR spectroscopy of nitrite complexes of methemoglobin
    David E Schwab
    Department of Chemistry and Biochemistry, Montana State University, P O Box 173400, Bozeman, Montana 59717, USA
    Inorg Chem 49:6330-7. 2010
    ..raised in recent studies of the structure and affinity of the nitrite ligand in complexes with Fe(III) in methemoglobin (metHb)...
  13. ncbi Accuracy of methemoglobin detection by pulse CO-oximetry during hypoxia
    John R Feiner
    Department of Anesthesia and Perioperative Care, University of California at San Francisco, 521 Parnassus Ave, San Francisco, CA 94143 0648, USA
    Anesth Analg 111:143-8. 2010
    b>Methemoglobin in the blood cannot be detected by conventional pulse oximetry, although it can bias the oximeter's estimate (Spo2) of the true arterial functional oxygen saturation (Sao2)...
  14. ncbi Plasma levels of lidocaine, o-toluidine, and prilocaine after application of 8.5 g Oraqix in patients with generalized periodontitis: effect on blood methemoglobin and tolerability
    Britt Marie Herdevall
    Specialist Dental Clinic, Sodertalje, Sweden
    Acta Odontol Scand 61:230-4. 2003
    ..5 g Oraqix (212.5 mg of lidocaine base and 212.5 mg of prilocaine base) in periodontal pockets was well tolerated and displayed a wide safety margin with respect to plasma levels normally associated with systemic toxicity...
  15. ncbi Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation
    Christian Stefani
    Iron Metabolism and Chelation Program, Department of Pathology, University of Sydney, Sydney, New South Wales 2006, Australia
    J Med Chem 56:357-70. 2013
    ..Major findings include that methemoglobin formation mediated by the lipophilic t-BuBpT series was significantly (p < 0.05-0...
  16. ncbi Interference of patent blue dye with pulse oximetry readings, methemoglobin measurements, and blue urine in sentinel lymph node mapping: a case report and review of the literature
    Hou Chuan Lai
    Department of Anesthesiology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Acta Anaesthesiol Taiwan 49:162-4. 2011
    ..The unexpected events might be a consequence of excessive administration of PB dye. We also reviewed the published discourses in literature on the adverse effects of PB dye...
  17. ncbi Methemoglobin formation by triapine, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and other anticancer thiosemicarbazones: identification of novel thiosemicarbazones and therapeutics that prevent this effect
    Patricia Quach
    Discipline of Pathology, University of Sydney, Sydney, New South Wales, Australia
    Mol Pharmacol 82:105-14. 2012
    ..These studies have demonstrated that 3-AP induces methemoglobin (metHb) formation and hypoxia in patients, limiting its usefulness...
  18. ncbi Methemoglobin exposure produces toxicological effects in macrophages due to multiple ROS spike induced apoptosis
    Rohitas Deshmukh
    Malaria Research Group, Department of Biotechnology, Indian Institute of Technology, Guwahati, Assam 781039, India
    Toxicol In Vitro 27:16-23. 2013
    ..Presence of methemoglobin in body fluids such as blood, cerebrospinal fluid and urine is associated with tissue damage...
  19. ncbi Methemoglobin incites primaquine toxicity through single-electron oxidation and modification
    S N Balaji
    Malaria Research Group, Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, Assam, India
    J Basic Clin Physiol Pharmacol 24:105-14. 2013
    ..Primaquine (Pq) metabolic products are responsible for drug-associated hemotoxicity and limit primaquine usage...
  20. ncbi Extracellular methemoglobin primes red blood cell aggregation in malaria: an in vitro mechanistic study
    S N Balaji
    Malaria Research Group, Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India
    FEBS Lett 587:350-7. 2013
    ..Ammonium sulfate fractionation and immunodepletion of methemoglobin from culture supernatant confirms methemoglobin as a major aggregant...
  21. pmc The near-iron transporter (NEAT) domains of the anthrax hemophore IsdX2 require a critical glutamine to extract heme from methemoglobin
    Erin S Honsa
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 288:8479-90. 2013
    ..Additionally, we used a spectroscopic analysis to show that IsdX2 NEAT domains only scavenge heme from methemoglobin (metHb) and that autoxidation of oxyhemoglobin to metHb must occur prior to extraction...
  22. ncbi Reactions of deoxy-, oxy-, and methemoglobin with nitrogen monoxide. Mechanistic studies of the S-nitrosothiol formation under different mixing conditions
    Susanna Herold
    Laboratorium für Anorganische Chemie, Eidgenossische Technische Hochschule, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 278:6623-34. 2003
    ..Our data strongly suggest that, because of mixing artifacts, care should be taken to use results from in vitro experiments to draw conclusion on the mechanism of the reaction in vivo...
  23. ncbi Effect of heavy metal exposure on blood haemoglobin concentration and methemoglobin percentage in Lumbricus terrestris
    A Calisi
    Department of Biological and Environmental Sciences and Technologies, University of Salento, via prov le Lecce Monteroni, 73100, Lecce, Italy
    Ecotoxicology 20:847-54. 2011
    ..possible effect of heavy metal (cadmium, copper, mercury) exposure on Hb concentration and oxidation state (methemoglobin formation) in the earthworm Lumbricus terrestris...
  24. ncbi Metmyoglobin and methemoglobin catalyze the isomerization of peroxynitrite to nitrate
    Susanna Herold
    Laboratorium für Anorganische Chemie, Eidgenossische Technische Hochschule, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Biochemistry 42:14036-46. 2003
    ..Moreover, the globin offers very little protection, as the heme-free (apoMb) and heme-blocked (metMbCN) forms only partly prevent nitration of free tyrosine...
  25. pmc Hemoglobin as a nitrite anhydrase: modeling methemoglobin-mediated N2O3 formation
    Kathrin H Hopmann
    Centre for Theoretical and Computational Chemistry and Department of Chemistry, University of Tromsø, N 9037 Tromsø, Norway
    Chemistry 17:6348-58. 2011
    ..be readily explained by the reaction Hb-Fe(3+)+NO(2)(-)+NO⇌Hb-Fe(2+)+N(2)O(3), the exact manner in which methemoglobin (Hb-Fe(3+)), nitrite and NO interact with one another is unclear...
  26. pmc An electron paramagnetic resonance study of the affinity of nitrite for methemoglobin
    Bradley I Goetz
    Department of Physics, Wake Forest University, Winston Salem, NC 27109, USA
    Nitric Oxide 22:149-54. 2010
    ..The latter reaction is hypothesized to involve reactions on NO, nitrite and methemoglobin to form N(2)O(3) in an anhydrase reaction...
  27. ncbi Cerebral malaria and the hemolysis/methemoglobin/heme hypothesis: shedding new light on an old disease
    Ana Pamplona
    Unidade de Malaria, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisboa, Portugal
    Int J Biochem Cell Biol 41:711-6. 2009
    ..In this review, we discuss the role of hemolysis, methemoglobin and free heme in CM, brought to light by our recent studies in mice as well as by other studies in humans.
  28. ncbi Consequences of methemoglobinemia in pregnancy in newborns, children, and adults: issues raised by new findings on methemoglobin catabolism
    Lucijan Mohorovic
    Department of Environmental Medicine, University of Rijeka School of Medicine, Rijeka, Croatia
    J Matern Fetal Neonatal Med 23:956-9. 2010
    The aim of this review is to warn about the effects of methemoglobin and its catabolic products and the toxic effects caused by environmental oxidants that cause high-risk pregnancy and may later impair the health of newborns, children ..
  29. pmc Synthesis, antimalarial, antileishmanial, antimicrobial, cytotoxicity, and methemoglobin (MetHB) formation activities of new 8-quinolinamines
    Kirandeep Kaur
    Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab 160 062, India
    Bioorg Med Chem 15:915-30. 2007
    ..Several analogs, notably 21-24, 26-32, and 60, showed less MetHb formation compared to primaquine indicating the potential of these compounds in 8-quinolinamine-based antimalarial drug development...
  30. pmc Blood levels of methemoglobin in patients with aluminum phosphide poisoning and its correlation with patient's outcome
    Babak Mostafazadeh
    Department of Medical Toxicology and Forensic Medicine, Loghman Hakim Poison Hospital, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    J Med Toxicol 7:40-3. 2011
    ..following aluminum phosphide (AlP) intoxication has been reported, probable effect of blood level of methemoglobin (Met-Hb) on outcome of AlP-poisoned patients has not yet been investigated...
  31. pmc The level of maternal methemoglobin during pregnancy in an air-polluted environment
    Lucijan Mohorovic
    Obstetric and Gynecologic Primary Care, Labin, Croatia
    Environ Health Perspect 111:1902-5. 2003
    ..determine if a correlation could be established between the ground-level concentrations of sulfur dioxide and methemoglobin concentrations in pregnant women when a coal-powered thermoelectric power plant was in operation ("dirty" ..
  32. ncbi Simulation study of methemoglobin reduction in erythrocytes. Differential contributions of two pathways to tolerance to oxidative stress
    Ayako Kinoshita
    Institute for Advanced Biosciences, Keio University, Fujisawa, Kanagawa 252 8520, Japan
    FEBS J 274:1449-58. 2007
    b>Methemoglobin (metHb), an oxidized form of hemoglobin, is unable to bind and carry oxygen. Erythrocytes are continuously subjected to oxidative stress and nitrite exposure, which results in the spontaneous formation of metHb...
  33. ncbi N-acetylcysteine reduces methemoglobin in vitro
    R O Wright
    Division of General Pediatrics, Children s Hospital, Boston, Massachusetts, USA
    Ann Emerg Med 28:499-503. 1996
    To determine whether N-acetylcysteine (NAC reduces methemoglobin.
  34. ncbi Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity
    Meenakshi Jain
    National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab 160 062, India
    J Med Chem 47:285-7. 2004
    ..yoelii nigeriensis strain in vivo. Compound 2 was also evaluated for methemoglobin (MetHb) toxicity...
  35. ncbi Internal electron transfer between hemes and Cu(II) bound at cysteine beta93 promotes methemoglobin reduction by carbon monoxide
    C Bonaventura
    Marine Freshwater Biomedical Center, Duke University Marine Laboratory, Beaufort, North Carolina 28516, USA
    J Biol Chem 274:5499-507. 1999
    ..The beta hemes in Cu(II)-metHb are reduced under CO at rates close to those observed for cytochrome c oxidase, where heme and copper are present together in the oxygen-binding site and where internal electron transfer also occurs...
  36. ncbi Nitric oxide scavenging by barley hemoglobin is facilitated by a monodehydroascorbate reductase-mediated ascorbate reduction of methemoglobin
    Abir U Igamberdiev
    Department of Plant Science, University of Manitoba, Winnipeg, MB, R3T 2N2 Canada
    Planta 223:1033-40. 2006
    ..NO scavenging is facilitated by monodehydroascorbate reductase mediating a coupled reaction involving ferric Hb reduction in the presence of ascorbate and NADH...
  37. ncbi Methemoglobin is a potent activator of endothelial cells by stimulating IL-6 and IL-8 production and E-selectin membrane expression
    Xueying Liu
    Department of Cell Biology and Molecular Medicine, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G 626, Newark, NJ 07103, USA
    Am J Physiol Cell Physiol 285:C1036-46. 2003
    ..Endothelial cells are direct targets of free Hb or its oxidative derivatives, including methemoglobin (MHb) and hemin...
  38. ncbi Perioperative changes in carbonylhemoglobin and methemoglobin during abdominal surgery: alteration in endogenous generation of carbon monoxide
    Ryoji Takeda
    Department of Surgery, Kyoto City Hospital, Higashitakada cho, Mibu, Nakagyo ku, Japan
    J Gastroenterol Hepatol 17:535-41. 2002
    ..Therefore, we investigated perioperative changes in CO generation during abdominal surgery...
  39. ncbi Trehalose glass-facilitated thermal reduction of metmyoglobin and methemoglobin
    Anandhi Ray
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Chem Soc 124:7270-1. 2002
    ....
  40. pmc Characterization of erythrocytic uptake and release and disposition pathways of nitrite, nitrate, methemoglobin, and iron-nitrosyl hemoglobin in the human circulation
    Yuen Yi Hon
    Clinical Center Pharmacy Department, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Drug Metab Dispos 38:1707-13. 2010
    ..model to describe the in vivo erythrocytic uptake and release and disposition pathways of nitrite, nitrate, methemoglobin, and iron-nitrosyl hemoglobin in the human circulation...
  41. ncbi The role of methemoglobinemia in early and late complicated pregnancy
    Lucijan Mohorovic
    Obstetric and Gynecologic Primary Care, Creska 2, 52221 Rabac, Labin, Croatia
    Med Hypotheses 68:1114-9. 2007
    The objective of this review was to direct attention about methemoglobin as a biomarker which has an important role in the detection of adverse effects of the oxidative stress, misbalanced production of ROS, RNS and RSS...
  42. ncbi Measurement of carboxyhemoglobin and methemoglobin by pulse oximetry: a human volunteer study
    Steven J Barker
    Department of Anesthesiology, University of Arizona College of Medicine, P O Box 245114, Tucson, Arizona 85724 5114, USA
    Anesthesiology 105:892-7. 2006
    A new eight-wavelength pulse oximeter is designed to measure methemoglobin and carboxyhemoglobin, in addition to the usual measurements of hemoglobin oxygen saturation and pulse rate...
  43. ncbi Antioxidant protein 2 prevents methemoglobin formation in erythrocyte hemolysates
    Karl M Stuhlmeier
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Vienna, Austria
    Eur J Biochem 270:334-41. 2003
    ..Recombinant AOP2 prevented induced as well as noninduced methemoglobin formation in erythrocyte hemolysates, indicating its antioxidant properties...
  44. ncbi [The involvement of nitric oxide in formation of hemoglobin oxygen-binding properties]
    V V Zinchuk
    Grodno Medical University, Belarus
    Usp Fiziol Nauk 34:33-45. 2003
    ..In reaction with hemoglobin NO forms methemoglobin, nitrosyl-hemoglobin (HbFe2+NO) and S-nitrosohemoglobin (SNO-Hb)...
  45. ncbi Hemoglobin autoxidation and regulation of endogenous H2O2 levels in erythrocytes
    Robert M Johnson
    Department of Biochemistry and Molecular Biology, Wayne State Medical School, 540 E Canfield, Detroit, MI 48201, USA
    Free Radic Biol Med 39:1407-17. 2005
    ..b>Methemoglobin and the rate of catalase inactivation by 3-amino-2,4,5-triazole (3-AT) were determined...
  46. ncbi In vitro evaluation of antioxidant properties of Cocos nucifera Linn. water
    Sudheer Kumar Mantena
    Department of Pharmacology, Collega of Pharmaceutical Sciences, Manipal 576 199, Karnataka, India
    Nahrung 47:126-31. 2003
    ..CW protected hemoglobin from nitrite-induced oxidation to methemoglobin when added before the autocatalytic stage of the oxidation...
  47. ncbi Vasoactivity of S-nitrosohemoglobin: role of oxygen, heme, and NO oxidation states
    Jack H Crawford
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Blood 101:4408-15. 2003
    ..This suggests that oxygen-dependent modulation of SNOHb vasoactivity does not occur by controlling the allosteric state of Hb but is a property of vessel responsiveness to nitrosovasodilators at low oxygen tensions...
  48. ncbi A 74-year-old woman with desaturation following surgery. Co-oximetry is the first step in making the diagnosis of dyshemoglobinemia
    Matthias W König
    Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Chest 123:613-6. 2003
  49. ncbi Nitrite disrupts multiple physiological functions in aquatic animals
    Frank B Jensen
    Institute of Biology, University of Southern Denmark, Campusvej 55, DK 5230 M Odense, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 135:9-24. 2003
    ..Rainbow trout fall into two groups with regard to susceptibility and physiological response. These two groups are not related to sex but show significant different nitrite uptake rates...
  50. ncbi Blood viscosity maintains microvascular conditions during normovolemic anemia independent of blood oxygen-carrying capacity
    Pedro Cabrales
    La Jolla Bioengineering Institute, La Jolla, CA, USA
    Am J Physiol Heart Circ Physiol 291:H581-90. 2006
    Responses to exchange transfusion with red blood cells (RBCs) containing methemoglobin (MetRBC) were studied in an acute isovolemic hemodiluted hamster window chamber model to determine whether oxygen content participates in the ..
  51. ncbi Kinetics of the reactions of nitrogen monoxide and nitrite with ferryl hemoglobin
    Susanna Herold
    Laboratorium für Anorganische Chemie, Eidgenossische Technische Hochschule, ETH Honggerberg, Zurich, Switzerland
    Free Radic Biol Med 34:531-45. 2003
    ..0 and 20 degrees C), but increases with decreasing pH (1.8 x 10(3) M(-1)s(-1) at pH 6.4 and 20 degrees C). Thus, under acidic conditions as found in ischemic tissues, this reaction may also have a physiological relevance...
  52. ncbi The effects of nitroglycerine on the redox status of rat erythrocytes and reticulocytes
    S D Marković
    Institute of Biology and Ecology, Faculty of Sciences, Kragujevac, Serbia
    Physiol Res 55:389-96. 2006
    ..However, NTG robustly increased concentration of methemoglobin (MetHb), suggesting that NTG bio-transformation was primarily connected with hemoglobin (Hb)...
  53. ncbi Blood storage for forensic hemoglobin analysis using CO-oximeter
    Naoya Watanabe
    Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Hokkaido Igaku Zasshi 78:289-95. 2003
    ..And changes in the values of oxyhemoglobin (O2Hb), methemoglobin (MetHb), carboxyhemoglobin (COHb), deoxyhemoglobin (HHb) and total hemoglobin (THb) were examined...
  54. ncbi Oxidation of hemoglobin to methemoglobin in intact erythrocyte by a hydroperoxide induces formation of glutathionyl hemoglobin and binding of alpha-hemoglobin to membrane
    Kaori Murakami
    Department of Nutrition and Health Science, Faculty of Human Environmental Science, Fukuoka Women s University, 1 1 1 Kasumigaoka, Higashi ku, Fukuoka, Japan
    Arch Biochem Biophys 417:244-50. 2003
    ..The formation of G-Hb occurred linearly until 10 min in parallel with the formation of methemoglobin (metHb) after exhaustion of reduced glutathione...
  55. ncbi Inhibitory effects of flavonoids on free radical-induced hemolysis and their oxidative effects on hemoglobin
    Shuji Kitagawa
    Niigata University of Pharmacy and Applied Life Sciences, Faculty of Pharmaceutical Sciences, Niigata, Japan
    Chem Pharm Bull (Tokyo) 52:999-1001. 2004
    ..of AAPH, the relatively hydrophobic flavonoids quercetin and morin induced the oxidation of oxyhemoglobin to methemoglobin. Oxidation by quercetin was especially marked. However, this oxidation did not induce hemolysis...
  56. pmc Cross-linking with O-raffinose lowers oxygen affinity and stabilizes haemoglobin in a non-cooperative T-state conformation
    Yiping Jia
    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research CBER, Food and Drug Administration FDA, Bethesda, Maryland 20892, USA
    Biochem J 384:367-75. 2004
    ..Although the physiological ramifications of locking HbA(0) in the T conformation with the O-raffinose are still unknown, valuable insights into haemoglobin function are provided by these studies of O-R-polyHbA(0)...
  57. ncbi Metabolism of pyrogallol to purpurogallin by human erythrocytic hemoglobin
    Kaori Miyazaki
    Department of Geriatric Medicine, Tokyo Medical University, Japan
    Tohoku J Exp Med 203:319-30. 2004
    ..having three hydroxy groups at the adjacent positions in the benzene ring, oxidized human oxyhemoglobin to methemoglobin and reduced human methemoglobin to oxyhemoglobin...
  58. ncbi Scavenging of reactive nitrogen species by oxygenated hemoglobin: globin radicals and nitrotyrosines distinguish nitrite from nitric oxide reaction
    Donatella Pietraforte
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    Free Radic Biol Med 37:1244-55. 2004
    ..Collectively, these results indicate that NO2- reaction with oxyHb causes an oxidative challenge not observed with *NO. The differences in oxidation mechanisms of *NO and NO2- are discussed...
  59. ncbi Laboratory assessment of oxygenation in methemoglobinemia
    Shannon Haymond
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Clin Chem 51:434-44. 2005
    ..This case conference reviews laboratory methods for assessing oxygenation status: arterial blood gases, pulse oximetry, and CO-oximetry. Caveats of these measurements are discussed in the context of two methemoglobinemia cases...
  60. ncbi Simultaneous monitoring of nitric oxide, oxyhemoglobin and deoxyhemoglobin from small areas of the rat brain by in vivo visible spectroscopy and a least-square approach
    Felipe A Martín
    Area de Psicobiologia, Universidad de La Laguna, Tenerife 38201, Canary Islands, Spain
    J Neurosci Methods 140:75-80. 2004
    ..Under physiological conditions, NO reacts with oxyhemoglobin (OxyHb) to form methemoglobin (MetHb) at a very high rate...
  61. ncbi Small angle x-ray scattering (SAXS) study of the extracellular Hemoglobin of Glossoscolex paulistus: effect of pH, iron oxidation state, and interaction with anionic SDS surfactant
    Emerson Luiz Gelamo
    Departamento de Quimica e Fisica Molecular, Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, USP, C P 780, 13560 970 Sao Carlos, Sao Paulo, Brazil
    J Biol Chem 279:33298-305. 2004
    ..Our results give support to conclude that the iron oxidation state is an important factor modulating the oligomeric dissociation...
  62. ncbi Hemoglobin mediated contraction of the isolated rat thoracic aorta: why is precontraction necessary?
    H W Kim
    Brown University and The Miriam Hospital, Providence, RI 02906, USA
    Artif Cells Blood Substit Immobil Biotechnol 33:27-36. 2005
    ..This may explain why the Hb mediated additional contraction occurs only after an agonist induced precontraction...
  63. ncbi Role of thiamine thiol form in nitric oxide metabolism
    A I Stepuro
    Institute of Biochemistry, National Academy of Sciences of Belarus, Bulvar Keninskogo Komsomola 50, 230017 Grodno, Belarus
    Biochemistry (Mosc) 70:339-49. 2005
    ..the release of nitric oxide was recorded by the production of nitrite or the oxidation of oxyhemoglobin to methemoglobin. The concentration of the thiol form in the body under physiological pH values (7.2-7.4) did not exceed 1.5-2...
  64. ncbi Nitric oxide scavenging by red blood cells as a function of hematocrit and oxygenation
    Ivan Azarov
    Department of Physics, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27109, USA
    J Biol Chem 280:39024-32. 2005
    ..These observations may have important physiological implications within the microvasculature and for pathophysiological disruption of nitric oxide homeostasis in diseases...
  65. ncbi UVA-ketoprofen-induced hemoglobin radicals detected by immuno-spin trapping
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 77:585-91. 2003
    ..The methemoglobin (metHb) radicals react covalently with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) to form nitroxyl radical ..
  66. ncbi Enalapril increases mitochondrial nitric oxide synthase activity in heart and liver
    Alberto Boveris
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Antioxid Redox Signal 5:691-7. 2003
    ..as determined by dual wavelength spectrophotometry (577-591 nm) following hemoglobin oxidation to methemoglobin. The response to enalapril treatment, attributed to a gene-mediated up-regulation of mitochondrial nitric ..
  67. ncbi Effects of choline on hemorheological properties and NO metabolism of human erythrocytes
    Tiago Santos
    Institute of Biochemistry, Faculty of Medicine, University of Lisbon, Avenida Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Clin Hemorheol Microcirc 29:41-51. 2003
    ..To determine the effects of choline on red blood cell membrane properties and NO metabolism...
  68. pmc The case of the missing NO-hemoglobin: spectral changes suggestive of heme redox reactions reflect changes in NO-heme geometry
    Angela Fago
    Nicholas School of the Environment and Earth Sciences, Duke University, Beaufort, NC 28516, USA
    Proc Natl Acad Sci U S A 100:12087-92. 2003
    ....
  69. ncbi A new sensitive assay reveals that hemoglobin is oxidatively modified in vivo
    Niels B J Vollaard
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK
    Free Radic Biol Med 39:1216-28. 2005
    ..The exercise-induced increase is short-lived, suggesting the existence of an active mechanism for repairing or removing the damaged heme proteins...
  70. ncbi Noninvasive in vivo monitoring of methemoglobin formation and reduction with broadband diffuse optical spectroscopy
    Jangwoen Lee
    Laser Microbeam and Medical Program, Beckman Laser Institute, 1002 Health Sciences Rd East, University of California, Irvine, CA 92612 1475, USA
    J Appl Physiol 100:615-22. 2006
    We present noninvasive, quantitative in vivo measurements of methemoglobin formation and reduction in a rabbit model using broadband diffuse optical spectroscopy (DOS)...
  71. ncbi Characterization of hydrogen peroxide removal reaction by hemoglobin in the presence of reduced pyridine nucleotides
    Noriyoshi Masuoka
    Department of Biochemistry, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, 700 8558, Okayama, Japan
    Biochim Biophys Acta 1637:46-54. 2003
    ..We deduced that the removal reaction by hemoglobin included formations of methemoglobin and the ferryl radical and reduction of the latter with pyridine nucleotides...
  72. ncbi Electron spin resonance investigation of semiquinone radicals formed from the reaction of ubiquinone 0 with human oxyhemoglobin
    Qiong Guo
    Laboratories of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 277:6104-10. 2002
    ..Subsequently UQ(0) bound to the beta-93 cysteinyl residue of HbO(2) to form a covalent-binding adduct responsible for the broad spectrum...
  73. ncbi Acetylphenylhydrazine induced haemoglobin oxidation in erythrocytes studied by Mössbauer spectroscopy
    S Croci
    Instituto di Scienze Fisiche, INFM-Udr Parma, University of Parma, Italy
    Biochim Biophys Acta 1568:99-104. 2001
    ....
  74. ncbi Apparent specific volume of human hemoglobin: effect of ligand state and contribution of heme
    Edward DeMoll
    Section of Neurobiology, School of Biological Sciences, Institute of Molecular and Cell Biology, and Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA
    Anal Biochem 363:196-203. 2007
    ..The contribution can be estimated from the difference between the measured volume of each molecular species and that calculated from the amino acid composition...
  75. ncbi Reaction of melatonin with hemoglobin-derived oxoferryl radicals and inhibition of the hydroperoxide-induced hemoglobin denaturation in red blood cells
    L Tesoriere
    Department of Pharmacological Sciences, University of Palermo, Italy
    J Pineal Res 31:114-9. 2001
    ..A decrease of heme loss and accumulation of soluble methemoglobin (met-Hb) are explained in terms of the interaction of the indoleamine with perferryl Hb (Hb[Fe(IV)=O]), a ..
  76. ncbi Inhaled nitric oxide improves survival rates during hypoxia in a sickle cell (SAD) mouse model
    R Martinez-Ruiz
    Department of Anesthesia Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    Anesthesiology 94:1113-8. 2001
    ..Changes in HbSAD oxygen affinity were not detected with NO breathing, and methemoglobin levels were low in all surviving mice...
  77. ncbi Modulation of erythrocyte hemorheological properties by band 3 phosphorylation and dephosphorylation
    Carlota Saldanha
    Instituto de Biopatologia Química and Unidade de Biopatologia Vascular, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa, Lisboa, Portugal
    Clin Hemorheol Microcirc 36:183-94. 2007
    ..In conclusion, the results suggest that erythrocyte aggregation index is dependent of the phosphorylated/dephosphorylated state of band 3...
  78. ncbi Transition of hemoglobin between two tertiary conformations: determination of equilibrium and thermodynamic parameters from the reaction of 5,5'-dithiobis(2-nitrobenzoate) with the CysF9[93]beta sulfhydryl group
    Kehinde Onwochei Okonjo
    Department of Chemistry, University of Ibadan, Ibadan, Nigeria
    Biophys Chem 128:56-62. 2007
    ..22+/-0.06. The standard enthalpy and entropy changes for the isomerization are DeltaH(o)(rt)=24.2 kJ mol(-1) and DeltaS(o)(rt)=68.8 JK(-1)mol(-1), respectively...
  79. ncbi [Effect of nebivolol on the blood oxygen transport]
    V V Zinchuk
    Eksp Klin Farmakol 70:44-7. 2007
    ..01), thereby indicating the dose dependence of the drug effect. Greater drug concentration resulted in higher methemoglobin level and nitrate/nitrite content...
  80. ncbi In vitro and in vivo kinetic handling of nitrite in blood: effects of varying hemoglobin oxygen saturation
    Arlin B Blood
    Center for Perinatal Research and Division of Neonatology, Loma Linda University School of Medicine, CA 92354, USA
    Am J Physiol Heart Circ Physiol 293:H1508-17. 2007
    ..10 mg/kg iv) was given to normoxic or hypoxic newborn lambs, and the time course of plasma nitrite and methemoglobin (MetHb) concentrations was measured...
  81. ncbi The heme pocket geometry of Lucina pectinata hemoglobin II restricts nitric oxide and peroxide entry: model of ligand control for the design of a stable oxygen carrier
    Walleska De Jesus-Bonilla
    Department of Chemistry, University of Puerto Rico, Mayaguez Campus, P O Box 9019, Mayagüez 00681 9019, Puerto Rico
    Biochemistry 46:10451-60. 2007
    ..Engineering of second-generation Hb-based oxygen therapeutics that are resistant to NO/H2O2-driven oxidation may ultimately require further optimization of the heme pocket architecture to limit heme exposure to solvent...
  82. ncbi Assay and characterization of the NO dioxygenase activity of flavohemoglobins
    Paul R Gardner
    Department of Chemistry, University of Dayton, Dayton, Ohio, USA
    Methods Enzymol 436:217-37. 2008
    ..14.12.17) activity and function of flavohemoglobins are described. The methods may also be applied to the discovery and design of inhibitors for use as antibiotics or as modulators of *NO signaling...
  83. ncbi Separation of hemoglobin variants in single human erythrocytes by capillary electrophoresis with laser-induced native fluorescence detection
    S J Lillard
    Department of Chemistry, Iowa State University, Ames 50011, USA
    J Chromatogr A 718:397-404. 1995
    ..Normal adult cells contained 9.6% and 4.8% glycated beta- and alpha-chains, respectively. Cells with elevated Hb A1 gave 30% and 12%, respectively. The amounts of glycated Hb and total Hb in a given cell were found to be uncorrelated...
  84. ncbi Iron nitrosyl hemoglobin formation from the reactions of hemoglobin and hydroxyurea
    Jinming Huang
    Department of Chemistry, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Biochemistry 41:2466-74. 2002
    ..Electron paramagnetic resonance spectroscopy shows that hydroxyurea reacts with oxy-, deoxy-, and methemoglobin to produce 2-6% of iron nitrosyl hemoglobin. No S-nitrosohemoglobin forms during these reactions...
  85. ncbi Inhibition of human hemoglobin autoxidation by sodium n-dodecyl sulphate
    Dayer Mohammad Reza
    Institute of Biochemistry and Biophysics, University of Tehran, Iran
    J Biochem Mol Biol 35:364-70. 2002
    ..The induction of the deoxy form in the presence of SDS was confirmed by densitometry techniques. The compact structure of deoxyhemoglobin blocks the formation of met-conformation in low SDS concentrations...
  86. ncbi In vivo spectroscopy: a novel approach for simultaneously estimating nitric oxide and hemodynamic parameters in the rat brain
    José L González-Mora
    Departamento de Fisiologia, Facultad de Medicina, Universidad de La Laguna, Tenerife 38071, Canary Islands, Spain
    J Neurosci Methods 119:151-61. 2002
    ..Under physiological conditions, NO reacts with oxyhemoglobin (OxyHb) to form methemoglobin (MetHb) at a very high rate...
  87. ncbi [Precision and accuracy of "a pocket" pulse oximeter in Mexico City]
    Luis Torre-Bouscoulet
    Clínica de Suefio, Instituto Nacional de Enfermedades Respiratorias, Tlalpan, DF Mexico
    Rev Invest Clin 58:28-33. 2006
    ..The objective was to evaluate the precision and accuracy of a "pocket" pulse oximeter at an altitude of 2,240 m above sea level...
  88. ncbi Interaction of sodium dodecyl sulfate with human native and cross-linked hemoglobins: a transient kinetic study
    Apurba Kumar Sau
    Department of Chemical Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Colaba, 400 005, Mumbai, India
    Biophys Chem 98:267-73. 2002
    ..83 mM) with human native and cross-linked oxyhemoglobin (oxyHb) and methemoglobin (metHb) has been investigated by optical spectroscopy and stopped-flow transient kinetic measurements...
  89. ncbi Site-specific cross-linking of human and bovine hemoglobins differentially alters oxygen binding and redox side reactions producing rhombic heme and heme degradation
    Enika Nagababu
    Molecular Dynamics Section, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224 6823, USA
    Biochemistry 41:7407-15. 2002
    ..These findings establish the importance of these secondary oxidative reactions over autoxidation in evaluating the toxicity of HBOCs...
  90. ncbi Potential interference by hydroxocobalamin on cooximetry hemoglobin measurements during cyanide and smoke inhalation treatments
    Jangwoen Lee
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA, USA
    Ann Emerg Med 49:802-5. 2007
    ..peak at 532 nm), we investigate potential interference effects of OHCob on total hemoglobin concentration (tHb), carboxyhemoglobin (COHb), methemoglobin (MetHb), and oxyhemoglobin (Hb-O2) cooximetry measurement values in blood.
  91. pmc Nitric oxide reaction with red blood cells and hemoglobin under heterogeneous conditions
    Tae H Han
    Department of Chemical Engineering, University of California, Los Angeles, CA 90095 1592, USA
    Proc Natl Acad Sci U S A 99:7763-8. 2002
    ..These results were supported further by mathematically modeling NO-Hb reactions and diffusion...
  92. pmc Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo
    Jacqueline Dunne
    Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK
    Biochem J 399:513-24. 2006
    ..g. haemolytic anaemias, subarachnoid haemorrhage, rhabdomyolysis...
  93. ncbi Role of redox potential of hemoglobin-based oxygen carriers on methemoglobin reduction by plasma components
    Scott C Dorman
    Department of Chemistry, University of South Alabama, Mobile, USA
    Artif Cells Blood Substit Immobil Biotechnol 30:39-51. 2002
    ..This is necessary for the reversible binding/release of molecular oxygen and minimization of methemoglobin (Fe+3) formation. Acellular hemoglobins are especially susceptible to oxidation and denaturation...
  94. ncbi Exposure to malondialdehyde induces an early redox unbalance preceding membrane toxicity in human erythrocytes
    Luisa Tesoriere
    Department of Pharmaceutical Toxicological and Biological Chemistry, University of Palermo, Italy
    Free Radic Res 36:89-97. 2002
    ..Accumulation of methemoglobin, and formation of small amounts of hemichrome were later evident...
  95. ncbi Oxygen-related processes in red blood cells exposed to tert-butyl hydroperoxide
    I K Dremza
    Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno, Belarus
    Redox Rep 11:185-92. 2006
    ..Neither GSH nor oxyhaemoglobin oxidation depended on oxygen pressure...
  96. ncbi The effect of simvastatin on erythrocyte membrane fluidity during oxidative stress induced by cardiopulmonary bypass: a randomized controlled study
    Raffaella Coccia
    Department of Biochemical Sciences, University La Sapienza, Rome, Italy
    Clin Ther 29:1706-17. 2007
    ..Abnormal erythrocyte deformability can cause severe complications during cardiopulmonary bypass (CPB) surgery, including both hemolysis and perfusion abnormalities...
  97. ncbi Antidotal treatment of cyanide poisoning
    Bruno Megarbane
    Réanimation Médicale et Toxicologique, Universite Paris VII, INSERM U26, Hospital Lariboisiere, Paris, France
    J Chin Med Assoc 66:193-203. 2003
    ..Oxygen counteracts efficiently cyanide action at the mitochondrial level. Sodium thiosulfate, methemoglobin forming agents and cobalt compounds act efficiently by complexing or transforming cyanide into non-toxic ..
  98. ncbi Mechanism of the contractile effect of diaspirin-cross-linked hemoglobin in rat isolated aorta strip denuded of endothelium as revealed using an oil-immersion procedure
    F Rioux
    Centre de Recherche, , , Canada
    Can J Physiol Pharmacol 74:1171-9. 1996
    ..to drugs in the Krebs medium followed by replacement of the Krebs medium by mineral oil) was mimicked by methemoglobin and metmyoglobin, but not by cytochrome c, albumin, hemin, hematin, Fe2+, and a variety of hemorphins...
  99. ncbi Two cases of methemoglobinemia following zopiclone ingestion
    Hin Tat Fung
    Tuen Mun Hospital, Hong Kong, China
    Clin Toxicol (Phila) 46:167-70. 2008
    ..Intoxication with zopiclone is expected to produce drowsiness, confusion and coma but not methemoglobinemia. We report two cases of zopiclone overdose with methemoglobinemia...
  100. ncbi The availability of toxicological analyses for poisoned patients in Ireland
    Nicola Cassidy
    National Poisons Information Centre, Beaumont Hospital, Dublin, Ireland
    Clin Toxicol (Phila) 48:373-9. 2010
    ..Some professional associations in different countries quote these guidelines but there are no data to support adherence to these recommendations in the medical literature...
  101. ncbi Ascaris suum NADH-methemo(myo)globin reductase systems recovering differential functions of hemoglobin and myoglobin, adapting to environmental hypoxia
    Shinzaburo Takamiya
    Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Parasitol Int 58:278-84. 2009
    ..and dually localized in extracellular perienteric fluid and hypodermis, is involved in both perienteric NADH-methemoglobin and cytosolic NADH-metmyoglobin reduction, where cytochrome b5 functions as an electron carrier between NADH-..

Research Grants35

  1. Noninvasive Methemoglobin Monitoring Technology
    LEONARD WINCHESTER; Fiscal Year: 2007
    ..applicant): This research is designed to meet a critical need for a noninvasive, reliable, and cost-effective methemoglobin sensor...
  2. Effect of Inducible Antioxidants on Hemoglobin Toxicity
    Raymond F Regan; Fiscal Year: 2010
    ..Hb toxicity is mediated by transfer of its heme moieties to nearby cells, which is favored by its oxidation to methemoglobin. Hemin, the oxidized form of heme, is then catabolized by the heme oxygenase enzymes to iron, carbon monoxide, ..
  3. Crystalline hydroxocobalamin and methemoglobin as a treatment of H2S intoxication
    PHILIPPE A HAOUZI; Fiscal Year: 2013
    ..H2S very rapidly in the blood and tissues of rats based on the use of the crystalline form of low dose of methemoglobin (as a source of ferric Iron) and high dose of Vitamin B12 (as a source of oxidized Cobalt)...
  4. Role of nitrite and hemoglobin in vascular NO homeostasis in the fetus and adult
    Arlin B Blood; Fiscal Year: 2013
    ..we will investigate the physiological importance of a recently discovered reaction between nitrite, NO, and methemoglobin, which may explain how the erythrocyte is capable of releasing vasoactive amounts of NO...
  5. Heme toxicity and vaso-occlusion in sickle cell disease
    Gregory M Vercellotti; Fiscal Year: 2013
    ..Hemolysis releases hemoglobin in the vasculature, which when oxidized to methemoglobin can release toxic heme that promotes a pro-oxidative, pro-inflammatory and pro-thrombotic environment...
  6. Acute Cyanide Toxicity, Complex IV, NO & Nitrite
    James Peterson; Fiscal Year: 2010
    ..has decreased, in part, because of the uncertain assumption that its mechanism of action is the induction of methemoglobin (MetHb)...
  7. Pulse CO-Oximeter for Multiple Hemoglobin Species
    JONAS POLOGE; Fiscal Year: 2009
    ..In reality, two other hemoglobin species -- carboxyhemoglobin (COHb) and methemoglobin (metHb), collectively termed dyshemoglobins -- are present at all times...
  8. CYTOCHROME B5--A CASE STUDY IN MOLECULAR RECOGNITION
    Mario Rivera; Fiscal Year: 1999
    ..The form found in erythrocytes is involved in the pathway for methemoglobin reduction...
  9. Analyses of gradient echo MRI data
    Yi Wang; Fiscal Year: 2013
    ..is particularly useful for studying blood deoxyhemoglobin (foundation of fMRI) and blood breakdown products, methemoglobin, hemosiderin and ferritin (various bleeding disorders including traumatic brain injury, hemorrhage and ..
  10. Quantitative Brain Tissue Magnetic Susceptibility Property Analyzer
    Yi Wang; Fiscal Year: 2011
    ..is particularly useful for studying blood deoxyhemoglobin (foundation of fMRI) and blood breakdown products, methemoglobin, hemosiderin and ferritin (various bleeding disorders including traumatic brain injury, hemorrhage and ..
  11. AUTO-ANALYZER FOR FIVE HEMOGLOBIN SPECIES AND BILIRUBIN
    JOHN STEINKE; Fiscal Year: 1992
    ..percent oxyhemoglobin saturation); percent HbCO (percent carboxyhemoglobin saturation); percent Hi (percent methemoglobin saturation; also known as hemiglobin); percent Hb (percent deoxyhemoglobin saturation); percent SHb (percent ..
  12. ERYTHROPOIETIC AND HEMODYNAMIC RESPONSE TO HYPOXEMIA
    John Widness; Fiscal Year: 1990
    ..Fetal hypoxemia will be induced by the intravenous infusion of sodium nitrite resulting in methemoglobin formation, and simultaneous P50 changes will be induced experimentally by fetal pH changes...
  13. IRON AND OXYGEN CHEMISTRIES IN SIPUNCULAN BLOOD
    DONALD KURTZ; Fiscal Year: 1992
    ..This system closely resembles that for reduction of methemoglobin in the human erythrocyte, which prevents methemoglobinemia...
  14. REFERENCE LABORATORY TO EVALUATE THERAPIES FOR SCD
    Toshio Asakura; Fiscal Year: 2004
    ..The SCD-RL also studies the adverse effects of potential drugs such as formation of methemoglobin, hemolysis, and/or increase in the amount of denatured hemoglobin inside RBCs...
  15. STRUCTURE-FUNCTION RELATIONSHIP OF HEMOGLOBIN A
    Ali Mansouri; Fiscal Year: 1980
    ..This work deals with the study of the influence of conformational changes on enzymatic methemoglobin reduction as well as with several aspects of oxidation...
  16. GENETIC SUSCEPTIBILITY TO AROMATIC AMINE TOXICITY
    CHARLENE MCQUEEN; Fiscal Year: 1992
    ..The major toxic responses to this class of chemicals are the production of methemoglobin and tumors...
  17. NONINVASIC OPTICAL SENSOR FOR HEMOGLOBIN MEASUREMENTS
    LEONARD WINCHESTER; Fiscal Year: 1999
    ..be measured are levels of oxyhemoglobin (O2Hb) reduced or deoxyhemoglobin (RHb), carboxyhemoglobin (COHb) and methemoglobin (MetHb). It also became evident that the approach could also be used to estimate hematocrit...
  18. PEDIATRIC SUB-MICROLITER BLOOD SAMPLING AND ASSAY
    Wilson Smart; Fiscal Year: 2000
    ..will then be inserted into the detector and the optical absorbance of oxy-hemoglobin, deoxy-hemoglobin, and methemoglobin will be measured using 3 light emitting diodes (LEDs)...
  19. IN VITRO IMMUNOTOXICITY STUDIES ON A HERBICIDE PROPANIL
    John Barnett; Fiscal Year: 2000
    ..Earlier studies showed a neurotoxic as well as a hematotoxic effects, i.e., propanil causes anemia and methemoglobin formation. The immunotoxic effects of propanil have been documented by Barnett and his coworkers...
  20. NOVEL ORGANIC REAGENTS FOR BIOMEDICAL APPLICATIONS
    RAMACHANDRA HOSMANE; Fiscal Year: 2002
    ..and investigate their physical, compositional, and functional properties, including molecular weight, methemoglobin levels, storage stability, oxygen affinity (P50), cooperativity (Hill n value), and dependence of P50 on pH (..
  21. OXYGEN TRANSPORT: HEMOGLOBINS WITH MODIFIED HEMES
    John Moffat; Fiscal Year: 1980
    ..Almost the last readily accessible liganded hemoglobin is nitrite methemoglobin which is unusual as it may be either N- or O-bonded; X-ray studies may reveal this...
  22. Mechanically Stable Blood Substitutes
    Andre Francis Palmer; Fiscal Year: 2010
    ..The proposed work is both innovative and significant, because novel LEAcHb hybrid vesicles with engineered structural and mechanical characteristics will be created for use as an artificial blood substitute. ..
  23. SPLENIC TOXICITY OF ANILINE
    M Firoze Khan; Fiscal Year: 2010
    ..These studies will elucidate the mechanisms of aniline-induced splenic toxicity, and will be important in devising strategies to prevent toxicity, and in risk assessment of aniline and other structurally-related aromatic amines. ..
  24. Enhanced O2 Delivery to C3A Hepatocytes
    Andre Palmer; Fiscal Year: 2009
    ..The knowledge gained from this study is expected to be of benefit in the design of hepatocyte containing HF bioreactors for use as potential BLADs. ..
  25. Xenobiotics, Lipid Peroxidation and Autoimmunity
    M Firoze Khan; Fiscal Year: 2006
    ..abstract_text> ..
  26. Effects of Nitric Oxide in Sickle Cell Blood
    DANIEL KIM SHAPIRO; Fiscal Year: 2006
    ..Our studies will help us understand important issues related to NO's role in sickle cell disease and in the general population. ..
  27. EARDA Transition: Further Enhance Faculty and Student R*
    Harpal Singh; Fiscal Year: 2005
    ..The administration enthusiastically supports, and is committed to the continuation of research development capability of faculty and students when EARDA funding concludes. ..
  28. Honors Undergraduate Research Training at SSU
    Harpal Singh; Fiscal Year: 2006
    ..A mandatory Bioethics course is proposed for MARC participants. The SSU MARC program is a concerted approach to enlarge the pool of minority biomedical scientists. ..
  29. PET Evaluation of Hemorrhagic Shock and Resuscitation
    Vibhudutta Awasthi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  30. RECEPTOR MEDIATED OXIDATIVE STRESS
    HOWARD SHERTZER; Fiscal Year: 2003
    ..These studies will improve our understanding of how PHAHs such as TCDD generate oxidative stress and mutagenesis, leading to better models for risk assessment and novel strategies for intervention in PHAH-mediated toxicity. ..
  31. Cohort Study of Nitrate Exposure, MHG, and Health
    Catherine Zeman; Fiscal Year: 2004
    ..diarrheal disease experiences), methemoglobinemia history and/or self reported symptoms, if any, current methemoglobin level, and lymphocyte response status as an indicator of immuno-competency; (a number of measures including ..
  32. Instrument to Measure Oxygen Affinity of Hemoglobin
    Kim Vandegriff; Fiscal Year: 2004
    ..abstract_text> ..
  33. Thermodynamic Properties of NADH:Nitrate Reductase
    Michael Barber; Fiscal Year: 2005
    ..These studies will enhance our understanding of important structure-function relationships in NR and other related metalloflavoproteins. ..
  34. Glutathione in Environmental Toxicity and Disease
    HOWARD SHERTZER; Fiscal Year: 2007
    ..Our proposed research should therefore help focus future genotype-phenotype association studies between the appropriate DNA variant sites in the GCLC and GCLM genes and disease. ..
  35. Metabolism and Carcinogenicity of Heterocyclic Amines
    TERRY ZENSER; Fiscal Year: 2007
    ..Determine effect of DSS-induced colitis inflammation) in IQ carcinogenicity. The long-term goal is to understand the role of RNOS on HCA carcinogenesis. ..