- Non-invasive screening for carbon monoxide toxicity in the emergency department is valuable
Ann Emerg Med 49:718-9; author reply 719. 2007
- Carboxyhemoglobin and blood cyanide concentrations in relation to aviation accidents
Dennis V Canfield
Civil Aerospace Medical Institute, Federal Aviation Administration, Oklahoma City, OK, USA
Aviat Space Environ Med 76:978-80. 2005
..It is important in aviation accident investigations to determine if a fire occurred during flight or after the crash and to establish the source(s) of the toxic gases...
- Analysis of factors that influence rates of carbon monoxide uptake, distribution, and washout from blood and extravascular tissues using a multicompartment model
Margaret C Bruce
Department of Physiology, University of Kentucky, Lexington, 40506 0070, USA
J Appl Physiol 100:1171-80. 2006
..experimental data from 15 human subjects, for whom subject-specific parameters were known, multiple washout carboxyhemoglobin (COHb) levels were available, and CO exposure conditions were identical, to investigate the contributions of ..
- Death scene evaluation in a case of fatal accidental carbon monoxide toxicity
Antioco Franco Sedda
FIS ION TRIGA Reactor, ENEA Casaccia, SP Anguillarese 301, 00060 Rome, Italy
Forensic Sci Int 164:164-7. 2006
..The death was attributed to an accidental poisoning from carbon monoxide due to a sum of unfortunate circumstances...
- Standardising analysis of carbon monoxide rebreathing for application in anti-doping
Anthony C Alexander
Department of Physiology, Australian Institute of Sport, Australia
J Sci Med Sport 14:100-5. 2011
..5 above baseline levels...
- Assessing the severity of inhalation injuries in adults
Manchester Burns and Plastic Surgery Service, Burns and Wound Research Office, Burn Centre, Acute Block, Wythenshawe Hospital, Manchester, United Kingdom
Burns 36:212-6. 2010
..Larger prospective studies using bronchoscopic findings and P/F ratio would give us a better indication as to the value of a scoring system in adults that are admitted with inhalation injuries...
- Evidence for carbon monoxide as the major factor contributing to lower fetal weights in rats exposed to cigarette smoke
Edward L Carmines
Philip Morris USA, Center for Research and Technology, Richmond, Virginia 23219, USA
Toxicol Sci 102:383-91. 2008
..The results of this study suggest that the observed reduction in fetal weight after exposure to cigarette smoke in rats is due to CO toxicity and not nicotine toxicity...
- Carboxyhemoglobin levels in patients with sickle-cell anemia: relationship to hemolytic and vasoocclusive severity
D A Sears
Department of Medicine, Baylor College of Medicine and Ben Taub General Hospital, Houston, Texas 77030, USA
Am J Med Sci 322:345-8. 2001
..Furthermore, in sickle-cell disease, as in other hemolytic diseases, endogenous carbon monoxide production is increased because of increased heme catabolism...
- Increased carboxyhemoglobin in adult falciparum malaria is associated with disease severity and mortality
Tsin W Yeo
Global Health Division, Menzies School of Health Research and Charles Darwin University, Royal Darwin Hospital, Darwin, Australia
J Infect Dis 208:813-7. 2013
Heme oxygenase 1 expression is increased in pediatric patients with malaria. The carboxyhemoglobin level (a measure of heme oxygenase 1 activity) has not been assessed in adult patients with malaria...
- Inappropriate reference intervals for carboxyhemoglobin at some Florida hospitals
David Van Sickle
Clin Chem 52:338. 2006
- Performance of the RAD-57 pulse CO-oximeter compared with standard laboratory carboxyhemoglobin measurement
Department of Emergency Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
Ann Emerg Med 56:382-8. 2010
We assess agreement between carboxyhemoglobin levels measured by the Rad-57 signal extraction pulse CO-oximeter (RAD), a Food and Drug Administration-approved device for noninvasive bedside measurement, and standard laboratory arterial ..
- Comparative subchronic inhalation study of smoke from the 1R4F and 2R4F reference cigarettes
Mark A Higuchi
R J Reynolds Tobacco Company, Research and Development, In Vivo Toxicology, Winston Salem, North Carolina 27102, USA
Inhal Toxicol 16:1-20. 2004
..Clinical signs, body and organ weights, clinical chemistry, hematology, carboxyhemoglobin, serum nicotine, pulmonary plethysmography, gross pathology, and histopathology were determined...
- Carbon monoxide and the nervous system
J A Raub
United States Environmental Protection Agency, National Center for Environmental Assessment, Mail Code B 243 01, Research Triangle Park, NC 27711, USA
Neurosci Biobehav Rev 26:925-40. 2002
..enters the bloodstream through the lungs and attaches to hemoglobin (Hb), the body's oxygen carrier, forming carboxyhemoglobin (COHb) and thereby reducing oxygen (O(2)) delivery to the body's organs and tissues...
- Prenatal cigarette smoke exposure: pregnancy outcome and gestational changes in plasma nicotine concentration, hematocrit, and carboxyhemoglobin in a newly standardized rat model
Department of Pediatrics, Institute of Maternal and Child Health, Health Sciences Center, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
Toxicol Appl Pharmacol 214:118-25. 2006
..moderate to heavy smokers (20-60 ng/ml), (2) investigate the temporal changes in plasma Nic concentrations, carboxyhemoglobin, and hematocrit with advancing pregnancy, and (3) elucidate the effects of CS exposure on pregnancy outcome...
- Urban air quality and carboxyhemoglobin levels in a group of traffic policemen
Department of Public Health and Microbiology, University of Torino, Via Santena 5 bis, 10126 Torino, Italy
Sci Total Environ 376:109-15. 2007
..The role played by traffic pollution, indoor air quality in offices and tobacco smoke on the expression of carboxyhemoglobin (COHb%) levels was investigated in a large group of traffic policemen in Torino city (North-Western Italy)...
- Accuracy of carboxyhemoglobin detection by pulse CO-oximetry during hypoxemia
John R Feiner
Department of Anesthesia and Perioperative Care, University of California, San Francisco, 521 Parnassus Ave, San Francisco, CA 94143 0648
Anesth Analg 117:847-58. 2013
..recent introduction of a multiwavelength "pulse CO-oximeter" (Masimo Rainbow SET(®) Radical-7), obtaining carboxyhemoglobin (COHb) levels in blood required blood sampling and laboratory analysis...
- Increased heme catabolism in critically ill patients: correlation among exhaled carbon monoxide, arterial carboxyhemoglobin, and serum bilirubin IXalpha concentrations
Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
Am J Physiol Lung Cell Mol Physiol 290:L114-9. 2006
It has been reported that exhaled carbon monoxide (CO) concentrations and arterial carboxyhemoglobin (CO-Hb) concentration in blood may be increased in critically ill patients...
- [Carbon monoxide poisoning in the autopsy material of the Department of Forensic Medicine, Medical University Of Białystok in years 1998-2008]
Z Zakładu Medycyny Sadowej Uniwersytetu Medycznego w Białymstoku
Arch Med Sadowej Kryminol 59:177-82. 2009
..The criteria under evaluation included gender, age, alcohol level, carboxyhemoglobin concentration and site of poisoning...
- In vivo detection of hemoglobin oxygen saturation and carboxyhemoglobin saturation with multiwavelength photoacoustic microscopy
MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Opt Lett 37:3414-6. 2012
A method for noninvasively detecting hemoglobin oxygen saturation (SO2) and carboxyhemoglobin saturation (SCO) in subcutaneous microvasculature with multiwavelength photoacoustic microscopy is presented...
- [Effects of a smoking cessation education on smoking cessation, endothelial function, and serum carboxyhemoglobin in male patients with variant angina]
Sook Hee Cho
Department of Nursing, Nambu University, Gwangju, Korea
J Korean Acad Nurs 42:190-8. 2012
The aim of this study was to evaluate the effects of a smoking cessation education on endothelial function and carboxyhemoglobin levels in smokers with variant angina.
- Accuracy of noninvasive multiwave pulse oximetry compared with carboxyhemoglobin from blood gas analysis in unselected emergency department patients
Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria
Ann Emerg Med 58:74-9. 2011
..Multiwave pulse oximetry might facilitate the screening for occult poisoning by noninvasive measurement of carboxyhemoglobin (COHb), but its reliability is still unknown...
- Second-hand smoking and carboxyhemoglobin levels in children: a prospective observational study
Branden E Yee
Tufts University School of Medicine, Boston, MA, USA
Paediatr Anaesth 20:82-9. 2010
To establish baseline noninvasive carboxyhemoglobin (COHb) levels in children and determine the influence of exposure to environmental sources of carbon monoxide (CO), especially environmental tobacco smoke, on such levels.
- Carbon monoxide poisoning
L K Weaver
Hyperbaric Medicine and Comprehensive Wound Care Centers, LDS Hospital, Utah, USA
Crit Care Clin 15:297-317, viii. 1999
..Given the neurocognitive sequelae following CO poisoning, increased awareness and prevention of CO poisoning is imperative...
- Carboxyhemoglobin levels in Kenyan children with Plasmodium falciparum malaria
Aubrey J Cunnington
Department of Paediatrics, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
Am J Trop Med Hyg 71:43-7. 2004
..It degrades heme, producing carbon monoxide (CO), which causes elevated levels of carboxyhemoglobin (COHb)...
- Biological chemistry of carbon monoxide
Claude A Piantadosi
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Antioxid Redox Signal 4:259-70. 2002
..This article provides a brief update on the biochemistry of CO as it relates to Hp binding, chemical oxidative processes, and cellular function...
- Carboxyhaemoglobin concentration, smoking habit, and mortality in 25 years in the Renfrew/Paisley prospective cohort study
C L Hart
University of Glasgow, Glasgow, UK
Heart 92:321-4. 2006
..To investigate how carboxyhaemoglobin concentration is related to smoking habit and to assess whether carboxyhaemoglobin concentration is related to mortality...
- Carboxyhemoglobin half-life in carbon monoxide-poisoned patients treated with 100% oxygen at atmospheric pressure
L K Weaver
Hyperbaric Medicine and Pulmonary Division, LDS Hospital, Salt Lake City, UT 84143, USA
Chest 117:801-8. 2000
There are large reported differences for the carboxyhemoglobin (COHb) half-life (COHb t(1/2)) in humans breathing 100% atmospheric O(2) following CO inhalation in tightly controlled experiments compared to the COHb t(1/2) observed in ..
- Arterial carboxyhemoglobin level and outcome in critically ill patients
Daniel D Melley
Department of Critical Care Medicine, Imperial College School of Medicine, Royal Brompton Hospital, London, UK
Crit Care Med 35:1882-7. 2007
Arterial carboxyhemoglobin is elevated in patients with critical illness. It is an indicator of the endogenous production of carbon monoxide by the enzyme heme oxygenase, which modulates the response to oxidant stress...
- Cardiovascular effects of carbon monoxide poisoning
Department of Cardiology, Erciyes University, School of Medicine, Kayseri, Turkey
Am J Cardiol 99:322-4. 2007
..B-type natriuretic peptide and carboxyhemoglobin levels were measured. Patients with increased cardiac markers underwent coronary angiography...
- Time and sample site dependency of the optimized co-rebreathing method
Christopher J Gore
Department of Physiology, Australian Institute of Sport, Canberra, Australia
Med Sci Sports Exerc 38:1187-93. 2006
..so we compared capillary with venous blood to determine whether sampling site altered the percentage of carboxyhemoglobin (%HbCO) and the reliability and accuracy of the "2-min Hbmass...
- Isocapnic hyperpnea accelerates carbon monoxide elimination
J A Fisher
Department of Anaesthesia, University of Toronto, Toronto and Department of Physiology, Queens University, Kingston, Ontario, Canada
Am J Respir Crit Care Med 159:1289-92. 1999
..We examined the effect of nonrebreathing isocapnic hyperpnea on the rate of decrease of carboxyhemoglobin levels (COHb) in five pentobarbital-anesthetized ventilated dogs first exposed to CO and then ventilated ..
- Acute respiratory diseases and carboxyhemoglobin status in school children of Quito, Ecuador
Corporación Ecuatoriana de Biotecnología, Quito, Ecuador
Environ Health Perspect 113:607-11. 2005
..CO binds to hemoglobin, forming carboxyhemoglobin (COHb), and reduces oxygen delivery...
- Increased arterial carboxyhemoglobin concentrations in chronic obstructive pulmonary disease
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
Am J Respir Crit Care Med 171:1246-51. 2005
Exhaled carbon monoxide (CO) and arterial blood carboxyhemoglobin concentrations (Hb-CO) increase in inflammatory pulmonary diseases.
- Toxicological evaluation of glycerin as a cigarette ingredient
E L Carmines
Philip Morris USA, P O Box 26583, Richmond, VA 23261 6583, United States
Food Chem Toxicol 43:1521-39. 2005
- Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity
P M Vanscheeuwijck
CRC Contract Research Center, Tollaan 101c, B 1932, Zaventem, Belgium
Food Chem Toxicol 40:113-31. 2002
..The data indicate that the addition of these 333 commonly used ingredients, added to cigarettes in three groups, did not increase the inhalation toxicity of the smoke, even at the exaggerated levels used...
- Carboxyhemoglobin levels in carbon monoxide poisoning: do they correlate with the clinical picture?
Neil B Hampson
Center for Hyperbaric Medicine, Section of Pulmonary and Critical Care Medicine, Virginia Mason Medical Center, Seattle, WA 98101, USA
Am J Emerg Med 26:665-9. 2008
It is commonly written that carboxyhemoglobin (COHb) measurements correlate with the clinical presentation of patients poisoned with carbon monoxide (CO). However, the evidence supporting this concept is scanty...
- Carbon monoxide poisoning
Claude A Piantadosi
Duke University Medical Center, Durham, NC 27710, USA
N Engl J Med 347:1054-5. 2002
- Increased blood carboxyhaemoglobin concentrations in inflammatory pulmonary diseases
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai 980 8574, Japan
Thorax 57:779-83. 2002
..A study was undertaken to determine whether arterial blood Hb-CO increases in patients with inflammatory pulmonary diseases...
- Carboxyhemoglobin elevation due to hemolytic anemia
Neil B Hampson
Center for Hyperbaric Medicine, Virginia Mason Medical Center, Seattle, Washington, USA
J Emerg Med 33:17-9. 2007
..hemolysis with associated endogenous carbon monoxide (CO) production resulted in elevation of the patient's carboxyhemoglobin (COHb) level to as high as 9.7%...
- High carboxyhemoglobin concentrations occur in swine during desflurane anesthesia in the presence of partially dried carbon dioxide absorbents
E J Frink
Department of Anesthesiology, The University of Arizona Health Sciences Center, Tucson 85724 5114, USA
Anesthesiology 87:308-16. 1997
Increased carboxyhemoglobin concentrations in patients receiving inhalation anesthetics (desflurane, enflurane, and isoflurane) have been reported...
- Relation of whole blood carboxyhemoglobin concentration to ambient carbon monoxide exposure estimated using regression
Carole B Rudra
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, State University of New York, 270 Farber Hall, Buffalo, NY 14214 8001, USA
Am J Epidemiol 171:942-51. 2010
..The authors examined the relation between estimated CO exposure and blood carboxyhemoglobin concentration in 708 pregnant western Washington State women (1996-2004)...
- Carboxyhemoglobin and its correlation to disease severity in cirrhotics
Tram T Tran
Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
J Clin Gastroenterol 41:211-5. 2007
To assess the correlation of serum carboxyhemoglobin (CO-Hb) to severity of liver disease as compared with Model for End Stage Liver Disease (MELD) score, Child Pugh score, and clinical parameters.
- Effects of increasing carboxyhemoglobin on the single breath carbon monoxide diffusing capacity
Brian L Graham
Division of Respirology, Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Am J Respir Crit Care Med 165:1504-10. 2002
Although carboxyhemoglobin (COHb) is often increased in smokers, American Thoracic Society recommendations for adjusting the single breath carbon monoxide (CO) diffusing capacity (DL(CO)(SB)) for COHb remain optional...
- Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation
Su N Kim
College of Pharmacy, Seoul National University, Shinrim Dong, Kwanak Ku, Seoul, Korea
Drug Metab Dispos 35:1754-8. 2007
..is metabolically converted to carbon monoxide mostly by CYP2E1 in liver, resulting in elevation of blood carboxyhemoglobin (COHb) levels...
- Subchronic inhalation by rats of mainstream smoke from a cigarette that primarily heats tobacco compared to a cigarette that burns tobacco
P H Ayres
R J Reynolds Tobacco Co, Research and Development, Division of Toxicology, PO Box 1236, Winston Salem, NC 27102, USA
Inhal Toxicol 13:149-86. 2001
..Clinical signs, body and organ weights, clinical chemistry, hematology, carboxyhemoglobin, serum nicotine, plethysmography, gross pathology, and histopathology were determined...
- Carboxyhemoglobin and thiocyanate as biomarkers of exposure to carbon monoxide and hydrogen cyanide in tobacco smoke
ABF Analytisch biologisches Forschungslabor GmbH, Goethestrasse 20, 80336 Munchen, Germany
Exp Toxicol Pathol 58:101-24. 2006
..Two 'classical' biomarkers of exposure to tobacco, namely carboxyhemoglobin (COHb and its equivalent carbon monoxide in exhalate, COex) and thiocyanate (SCN) in body fluids are ..
- Measurement of carboxyhemoglobin and methemoglobin by pulse oximetry: a human volunteer study
Steven J Barker
Department of Anesthesiology, University of Arizona College of Medicine, P O Box 245114, Tucson, Arizona 85724 5114, USA
Anesthesiology 105:892-7. 2006
A new eight-wavelength pulse oximeter is designed to measure methemoglobin and carboxyhemoglobin, in addition to the usual measurements of hemoglobin oxygen saturation and pulse rate...
- Carbon monoxide exposure from cooking in snow caves at high altitude
L E Keyes
Women s Health Research Center, University of Colorado Health Sciences Center, Denver, USA
Wilderness Environ Med 12:208-12. 2001
..We hypothesized that ambient CO and serum carboxyhemoglobin (COHb) levels would increase and that even low levels of COHb would be associated with symptoms of CO ..
- Low-flow anesthesia and reduced animal size increase carboxyhemoglobin levels in swine during desflurane and isoflurane breakdown in dried soda lime
Department of Anesthesiology, Hospital Juan Canalejo, La Coruna, Spain
Anesth Analg 89:909-16. 1999
..of animal size, anesthetic concentration, and fresh gas flow (FGF) rate on inspired carbon monoxide (CO) and carboxyhemoglobin (COHb) during anesthesia in swine, using soda lime previously dried to 1 +/- 0.1% water content...
- Carboxyhemoglobin formation as an unexpected side effect of inhaled nitric oxide therapy in severe acute respiratory distress syndrome
Division of Critical Care, Department of Internal Medicine, University Hospital, Lausanne, Switzerland
Crit Care Med 32:2537-9. 2004
..To report an unexpected cause of carboxyhemoglobinemia associated with inhaled nitric oxide therapy in severe acute respiratory distress syndrome...
- The dose-response relationship between cigarette consumption, biochemical markers and risk of lung cancer
M R Law
BUPA Epidemiology Research Group, Department of Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, St Bartholomew s and The Royal London School of Medicine, UK
Br J Cancer 75:1690-3. 1997
..The anomaly is explained by the observation that heavier smokers inhale less smoke from each cigarette...
- Suicide by inhalation of carbon monoxide in a residential fire
Laboratoire de Sciences Judiciaires et de Médecine Légale, Edifice Wilfrid Derome, 1701, Parthenais street, 12th Floor, Montreal, Quebec, Canada
J Forensic Sci 50:937-8. 2005
..The autopsy revealed smoke inhalation and the toxicological analysis revealed carboxyhemoglobin levels of 67%...
- Chronic inhalation of carbon monoxide: effects on the respiratory and cardiovascular system at doses corresponding to tobacco smoking
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Toxicology 228:280-90. 2006
..The effects on the cardiovascular system seem to involve myocardial hypertrophy, but not atherogenesis...
- Pulmonary gas exchange and educational level: a community study
Dept of Thoracic Medicine, Institute of Medicine, University of Bergen, N 5021 Bergen, Norway
Eur Respir J 23:583-8. 2004
..Such risk factors may, for instance, be higher exposure to airborne pollutants, poorer housing conditions, or lower consumption of fruit and vegetables. Further exploration is called for...
- The hemoglobin cyanomet ligation analogue and carbon monoxide induce similar allosteric mechanisms
Dipartimento di Scienze e Tecnologie Biomediche, University of Milano, L I T A, Via Fratelli Cervi, 93, I 20090 Segrate MI, Italy
Biophys Chem 109:201-13. 2004
- Potential interference by hydroxocobalamin on cooximetry hemoglobin measurements during cyanide and smoke inhalation treatments
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, CA, USA
Ann Emerg Med 49:802-5. 2007
..peak at 532 nm), we investigate potential interference effects of OHCob on total hemoglobin concentration (tHb), carboxyhemoglobin (COHb), methemoglobin (MetHb), and oxyhemoglobin (Hb-O2) cooximetry measurement values in blood.
- [A study on the effect of methanal during determination of carbon monoxide in blood]
You Yi Yan
West China School of Preclinical and Forensic and Medicine, Sichuan University, Chengdu 610044, China
Fa Yi Xue Za Zhi 20:23-5. 2004
To confirm whether formaldehyde disturb detecting carbon monoxide in blood. To give an evidence that can be used for detecting carboxyhemoglobin more accurately in carbon monoxide posioning appraises.
- Carbon monoxide poisoning while using a small cooking stove in a tent
Department of Anaesthesia and Intensive Care, Hammerfest Hospital, Hammerfest, Norway
Am J Emerg Med 22:204-6. 2004
..Venous blood samples were obtained every 15 minutes for measurement of carboxyhemoglobin (COHb). After 2 hours, all the subjects had significant CO levels in their blood (mean COHb = 21.5%)...
- Determination of carboxyhemoglobin levels and health effects on officers working at the Istanbul Bosphorus Bridge
Institute of Environmental Sciences, Bogazici University, Istanbul, Turkey
J Environ Sci Health A Tox Hazard Subst Environ Eng 39:1129-39. 2004
..The purpose of this research was to determine the relation between carboxyhemoglobin (COHb) and CO levels and its health effects on cashiers working at the Istanbul Bosphorus Bridge...
- COHb% as a marker of cardiovascular risk in never smokers: results from a population-based cohort study
Department of Clinical Sciences in Malmo, Epidemiological Research Group, Lund University, Malmo University Hospital, Malmo, Sweden
Scand J Public Health 34:609-15. 2006
..The objective in this population-based cohort study has been to describe inter-individual differences in COHb% in never smokers and to estimate the associated cardiovascular risk...
- The optimised CO-rebreathing method: a new tool to determine total haemoglobin mass routinely
Department of Sports Medicine and Sports Physiology, University of Bayreuth, Universitatsstrasse 30, 95440, Bayreuth, Germany
Eur J Appl Physiol 95:486-95. 2005
..Inhaling a CO-bolus markedly simplifies the CO-rebreathing method without reducing validity and reliability and can be used for routine determination of tHb for various indications...
- [Why should we discuss CO poisoning now?]
Chudoku Kenkyu 19:11-2. 2006
- Multiple active site conformers in the carbon monoxide complexes of trematode hemoglobins
Tapan K Das
Pfizer Global Biologics, Chesterfield, Missouri 63017, USA
J Biol Chem 281:11471-9. 2006
..In this conformer, the B10 Tyr assumes an alternative conformation consistent with one of the conformers seen the crystal structure. Implications of the multiple configurations on the ligand kinetics are discussed...
- [Carbon monoxide poisoning in the autopsy material of the Department of Forensic Medicine, Medical University of Białystok in the years 1998-2003]
Zakładu Medycyny Sadowej, Akademii Medycznej w Białymstoku
Arch Med Sadowej Kryminol 55:42-6. 2005
..0%) of a total of 2408 autopsy reports reviewed. Possible relationships between carboxyhemoglobin concentration and ethanol concentration, age and gender of the victims were assessed...
- Noninvasive fireground assessment of carboxyhemoglobin levels in firefighters
David C Cone
Division of EMS, Section of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut 06519 1315, USA
Prehosp Emerg Care 9:8-13. 2005
b>Carboxyhemoglobin (COHb) levels can be estimated by chemical analysis of exhaled alveolar breath. Such noninvasive measurement could be used on the fireground to screen both firefighters (FFs) and victims...
- [The producer-gas epidemic and an important hematologic discovery]
Lakartidningen 102:2007-8. 2005
- [Levels of carbon monoxide and hydrogen cyanide in blood of fire victims in the autopsy material of the Department of Forensic Medicine, Medical University of Białystok]
Zakładu Medycyny Sadowej Akademii Medycznej w Białymstoku
Arch Med Sadowej Kryminol 55:130-3. 2005
..8 to 39.2 microg/l, the COHb levels ranged from 16.0 to 85.0%. The level of hydrogen cyanide was determined by the pyrazolopyridine method modified by Nedoma, and the COHb level was determined by the Wolff method...
- [Pathophysiology, myths and mysteries of acute carbon monoxide poisoning]
Chudoku Kenkyu 19:23-33. 2006
- Carbon monoxide
Children s National Medical Center, Washington, DC, USA
Pediatr Rev 26:150-1. 2005
- [Precision and accuracy of "a pocket" pulse oximeter in Mexico City]
Clínica de Suefio, Instituto Nacional de Enfermedades Respiratorias, Tlalpan, DF Mexico
Rev Invest Clin 58:28-33. 2006
..The objective was to evaluate the precision and accuracy of a "pocket" pulse oximeter at an altitude of 2,240 m above sea level...
- [The role of ethanol in complex poisonings with carbon monoxide and hydrogen cyanide in fire victims]
Z Katedry Medycyny Sadowej Slaskiej Akademii Medycznej w Katowicach
Arch Med Sadowej Kryminol 56:9-14. 2006
..It was also shown that the increased ethanol caused a drop in HbCO and HCN levels. To evaluate HbCO and HCN levels, the regression and correlation analysis was used...
- [Carbon monoxide contamination: an environmental health problem]
Departmento de Toxicologia, Facultad de Medicina, Universidad Nacional de Colombia
Rev Salud Publica (Bogota) 8:108-17. 2006
..Lack of memory, attention, concentration and Parkinson-type altered movement are the neuropsychological changes most frequently associated with chronic exposure to low levels of carbon monoxide and carboxyhaemoglobin...
- Effect of combined exposure to carbon monoxide and cyanides in selected forensic cases
Department of Medicine and Public Health, Institute of Legal Medicine, University of Verona, Policlinico G B Rossi, P le L A Scuro, 37134 Verona, Italy
J Clin Forensic Med 11:264-7. 2004
..Two case studies are presented here, in which the results of the toxicological examinations are quite different, and the contributions of CO and HCN in a fire asphyxiation are considered...
- A suicide using a homemade carbon monoxide "death machine"
Joseph A Prahlow
South Bend Medical Foundation and Indiana University School of Medicine South Bend Center for Medical Education at the University of Notre Dame, South Bend, Indiana 46601, USA
Am J Forensic Med Pathol 26:177-80. 2005
..Presented herein is a case of suicidal CO poisoning in which the CO was produced via a chemical reaction between formic acid and sulfuric acid within a homemade device...
- Spectroscopic and functional characterization of T state hemoglobin conformations encapsulated in silica gels
Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Ullman 303, Bronx, New York 10461, USA
Biochemistry 43:13674-82. 2004
..Thus, it appears that the encapsulation protocol-dependent rate of ligand-binding-induced relaxation determines the functional properties of the initially encapsulated deoxy-HbA population...
- Short-term exposure evaluation of adult smokers switching from conventional to first-generation electrically heated cigarettes during controlled smoking
Hans J Roethig
Philip Morris USA, Clinical Evaluation, 615 Maury Street, Richmond, VA 23224 4121, USA
J Clin Pharmacol 45:133-45. 2005
..in 110 male and female adult smokers evaluated biomarkers of tobacco smoke exposure (carbon monoxide [CO], carboxyhemoglobin [CO-Hb], nicotine, urine mutagenicity) under controlled smoking conditions when adult smokers of 1 ..
- Myocardial dysfunction and potential cardiac hypoxia in rats induced by carbon monoxide inhalation
Intensive Care Unit and Hyperbaric Regional Center, University Hospital of Lille, Lille, France
Am J Respir Crit Care Med 174:320-5. 2006
..Although neurologic mechanisms have been investigated, the effects of CO on cardiovascular function are still poorly understood...
- Acute carbon monoxide exposure: diagnosis evaluation, treatment
Quinnipiac University, Hamden, Conn, USA
JAAPA 18:41-6. 2005
- Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs
Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Sezione di Biochimica e Fisiologia Veterinaria, Universita degli Studi di Milano, Milan, Italy
FASEB J 19:2045-7. 2005
..Lastly, CO pretreatment prevents LPS-induced ICAM expression on lung endothelium and inhibits leukocyte marginalization on lung parenchyma...
- Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery: role of circulating ATP
Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
Circ Res 91:1046-55. 2002
- Carbon monoxide inhalation reduces pulmonary inflammatory response during cardiopulmonary bypass in pigs
Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Germany
Anesthesiology 108:1025-36. 2008
..The authors hypothesized that inhaled carbon monoxide before initiation of CPB would reduce inflammatory response in the lungs...
- A randomized, controlled exposure study in adult smokers of full flavor Marlboro cigarettes switching to Marlboro Lights or Marlboro Ultra Lights cigarettes
Philip Morris USA Research Center, Clinical Evaluation, 4201 Commerce Road, Richmond, VA 23234, USA
Regul Toxicol Pharmacol 51:295-305. 2008
..Conclusions. Switching smokers to lower FTC tar yield cigarettes, on average, reduces nicotine and other biomarkers considered surrogates of tar exposure...
- Toxicity of fire smoke
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
Crit Rev Toxicol 32:259-89. 2002
..above can sometimes be the principal cause of death or their addition can result in much lower than expected carboxyhemoglobin levels in fire victims...
- Determination of plasma volume in anaesthetized piglets using the carbon monoxide (CO) method
J K Heltne
Department of Anaesthesia and Intensive Care, Haukeland University Hospital, University of Bergen, N 5021 Bergen, Norway
Lab Anim 36:344-50. 2002
..The agreement between the compared methods was satisfactory. Plasma volume determined with the CO method is safe, accurate and has no signs of major side effects...
- Affinity of carbon monoxide to hemoglobin increases at low oxygen fractions
Department of Anaesthesiology and Intensive Care, University of Munster, Munster, Germany
Biochem Biophys Res Commun 295:975-7. 2002
..However, it is still debated why the paradoxical arterio-venous carboxyhemoglobin (COHb) difference occurs only during critical illness but not in healthy volunteers...
- Analysis of carbon monoxide
Medical Toxicology Unit, Guy s and St Thomas Hospital NHS Trust, Avonley Road, London SE14 5ER, UK
Ann Clin Biochem 39:378-91. 2002
..Gas chromatographic methods are also appropriate when examining post-mortem blood samples where putrefaction or heat stress has resulted in a significant change in haemoglobin composition...
- Kinetics of nitric oxide binding to R-state hemoglobin
Department of Physics, Wake Forest University, Winston Salem, North Carolina 27109, USA
Biochem Biophys Res Commun 292:812-8. 2002
..1 +/- 0.1) x 10(7) (s(-1) M(-1)), which is essentially the same as that reported for T-state NO binding. (c)2002 Elsevier Science (USA)...
- Lipid peroxidation in the rat brain after CO inhalation is temperature dependent
Department of Legal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Free Radic Biol Med 31:1417-23. 2001
..Hypothermia may be applicable to treat patients after CO inhalation...
- Inhaled carbon monoxide and hyperoxic lung injury in rats
C E Clayton
Division of Pulmonary Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Physiol Lung Cell Mol Physiol 281:L949-57. 2001
..Thus significant protection by CO against O(2)-induced lung injury could not be confirmed in rats, even at CO concentrations associated with apoptosis in the brain...
- Spectral characteristics of a compound altering cytochrome P450 spectra from vertebrate microsomes suggest that it is a functional protein
T A Rocha-e-Silva
Department of Physiological Sciences, , SP, , Brazil
Comp Biochem Physiol C Toxicol Pharmacol 130:53-66. 2001
..The possibility that an unknown protein may substitute for cytochrome P450 in microsomes under certain environmental conditions and play a role in animal adaptation to unfavorable environmental fluctuations is discussed...
- Acute effects of passive smoking on the coronary circulation in healthy young adults
Department of Internal Medicine and Cardiology, Osaka City University Medical School, 1-4-3 Asahimachi Abeno-ku, Osaka City, Japan 545-8585
JAMA 286:436-41. 2001
..001). CONCLUSIONS: Passive smoking substantially reduced CFVR in healthy nonsmokers. This finding provides direct evidence that passive smoking may cause endothelial dysfunction of the coronary circulation in nonsmokers...
- Increased exhaled carbon monoxide concentration during living donor liver transplantation
Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
Int J Mol Med 21:75-81. 2008
..72 ppm (p<0.0001). There was an excellent correlation among an increase in CO concentration, arterial carboxyhemoglobin levels at the time of reperfusion (r(2)=0.19, p=0...
- Ligand migration and binding in the dimeric hemoglobin of Scapharca inaequivalvis
Institute of Biophysics, University of Ulm, 89069 Ulm, Germany
Biochemistry 46:14018-31. 2007
..For HbI, the so-called histidine gate mechanism proposed for other globins appears as a plausible entry/exit route as well...
- Population pharmacokinetic analysis of carboxyhaemoglobin concentrations in adult cigarette smokers
Projections Research Inc, Phoenixville, PA, USA
Br J Clin Pharmacol 65:30-9. 2008
..To develop a population-based model to describe and predict the pharmacokinetics of carboxyhaemoglobin (COHb) in adult smokers...
- Loss of CO from the intravascular bed and its impact on the optimised CO-rebreathing method
Department of Sports Medicine and Sports Physiology, University of Bayreuth, Universitaetsstrasse 30, 95447 Bayreuth, Germany
Eur J Appl Physiol 100:383-91. 2007
..The loss of CO due to exhalation and diffusion to myoglobin is of minor impact. It should, however, be considered by using correction factors to obtain high accuracy when determining total haemoglobin mass...
- Effects of levels of cigarette smoke exposure on symptom-limited spiroergometry
Department of Research, Development and Engineering, Clinical Evaluation, Philip Morris USA, Richmond, VA 23234, USA
Prev Cardiol 10:83-91. 2007
..8 x 10(3) mm Hg/min [P<.01 vs CC;] CC, 30.7+/-29.2+/-3.6 x 10(3) mm Hg/min) indicating that reduced exposure from tobacco smoke and NS for 3 days may improve cardiovascular function as detected by symptom-limited spiroergometry...
- Alarming levels of carboxyhemoglobin in a unit of banked blood
Departments of Anesthesiology and Cardiothoracic Surgery, Albany Medical Center, New York 12208, USA
Anesth Analg 97:289-90, table of contents. 2003
Increased levels of carboxyhemoglobin (COHb) are frequently found in units of packed red blood cells...
- [Opinionating on the cause of poisoning and death in fire victims]
Z Katedry Medycyny Sadowej Slaskiej Akademii Medycznej w Katowicach
Arch Med Sadowej Kryminol 57:231-5. 2007
..Alcohol intoxication status of the victims was also determined. Based on the obtained results, comprehensive toxicological and medico-legal opinions on the cause of death of all the examined fire-associated fatalities were done...
- A multicompartment model of carboxyhemoglobin and carboxymyoglobin responses to inhalation of carbon monoxide
Eugene N Bruce
Center for Biomedical Engineering, University of Kentucky, Lexington, KY 40506 0070, USA
J Appl Physiol (1985) 95:1235-47. 2003
..dissociation curve is represented by a modified Hill equation whose parameters are functions of the carboxyhemoglobin (HbCO) level...
- Exhaled carbon monoxide levels change in relation to inspired oxygen fraction during general anesthesia
Department of Anesthesiology, Kitano Hospital, The Tazuke Kofukai Medical Research Institute, Osaka, Japan
Anesth Analg 105:696-9. 2007
..The fraction of inspired oxygen (Fio2) is often changed during artificial ventilation. To investigate the effect of changes of Fio2 on exhaled CO, we measured exhaled CO levels during general anesthesia...
- Distal ligand reactivity and quaternary structure studies of proximally detached hemoglobins
T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore Maryland 21218, USA
Biochemistry 40:3780-95. 2001
..Some residual allosteric interactions may remain operative at the beta-chains of rHb (alphaH87G)...