fibrin tissue adhesive

Summary

Summary: An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.

Top Publications

  1. ncbi Randomized clinical trial investigating the use of drains and fibrin sealant following surgery for breast cancer
    P K Jain
    Department of Surgery, Scarborough General Hospital, Woodland Drive, Scarborough YO12 6QL, UK
    Br J Surg 91:54-60. 2004
  2. ncbi Surgical management of anal fistulae: a systematic review
    A I Malik
    Colorectal Unit, Department of Surgery, Northern General Hospital, Sheffield, UK
    Colorectal Dis 10:420-30. 2008
  3. pmc Conjunctivolimbal autograft using a fibrin adhesive in pterygium surgery
    Hyun Ho Kim
    Department of Ophthalmology, Cheil Eye Hospital, Daegu, Korea
    Korean J Ophthalmol 22:147-54. 2008
  4. ncbi Preventing seroma in the latissimus dorsi flap donor site with fibrin sealant
    Jonathan C Weinrach
    Christus St Joseph Hospital, Plastic Surgery Residency Program, Houston, TX 77002, USA
    Ann Plast Surg 53:12-6. 2004
  5. ncbi The current status of tissue glues: part II. For adhesion of soft tissues
    Arun K Gosain
    Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee 53226, USA
    Plast Reconstr Surg 110:1581-4. 2002
  6. ncbi The venous graft as an effector of early angiogenesis in a fibrin matrix
    E Polykandriotis
    Department of Plastic and Hand Surgery, University of Erlangen Medical Center, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Microvasc Res 75:25-33. 2008
  7. ncbi Prevention of lymphorrhea by means of fibrin glue after axillary lymphadenectomy in breast cancer: prospective randomized trial
    F N Gilly
    Department of Surgery, Centre Hospitalo Universitaire Lyon Sud, Pierre Benite, France
    Eur Surg Res 30:439-43. 1998
  8. ncbi Fibrin glue treatment of complex anal fistulas has low success rate
    Rasmy Loungnarath
    Section of Colon and Rectal Surgery, Washington University School of Medicine Barnes Jewish Hospital, St Louis, Missouri, USA
    Dis Colon Rectum 47:432-6. 2004
  9. ncbi The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC): method description and recent developments
    Jan Philipp Benthien
    Department of Orthopaedic Surgery, University of Basel, Basel, Switzerland
    Knee Surg Sports Traumatol Arthrosc 19:1316-9. 2011
  10. ncbi A new fibrin sealant from Crotalus durissus terrificus venom: applications in medicine
    L C Barros
    Centro de Estudos de Venenos e Animais Peconhentos, Universidade Estadual Paulista, UNESP, Botucatu, Sao Paulo State, Brasil
    J Toxicol Environ Health B Crit Rev 12:553-71. 2009

Detail Information

Publications253 found, 100 shown here

  1. ncbi Randomized clinical trial investigating the use of drains and fibrin sealant following surgery for breast cancer
    P K Jain
    Department of Surgery, Scarborough General Hospital, Woodland Drive, Scarborough YO12 6QL, UK
    Br J Surg 91:54-60. 2004
    ..The aim of this study was to evaluate the effect of drains and fibrin sealant on the incidence of seroma formation...
  2. ncbi Surgical management of anal fistulae: a systematic review
    A I Malik
    Colorectal Unit, Department of Surgery, Northern General Hospital, Sheffield, UK
    Colorectal Dis 10:420-30. 2008
    ..We aimed to systematically review the available studies relating to the surgical management of anal fistulas...
  3. pmc Conjunctivolimbal autograft using a fibrin adhesive in pterygium surgery
    Hyun Ho Kim
    Department of Ophthalmology, Cheil Eye Hospital, Daegu, Korea
    Korean J Ophthalmol 22:147-54. 2008
    ..To evaluate the efficacy and safety of fibrin bioadhesive in conjunctivolimbal autograft surgery for primary pterygium...
  4. ncbi Preventing seroma in the latissimus dorsi flap donor site with fibrin sealant
    Jonathan C Weinrach
    Christus St Joseph Hospital, Plastic Surgery Residency Program, Houston, TX 77002, USA
    Ann Plast Surg 53:12-6. 2004
    ..047). This compares favorably with seroma rates as high as 79% described in the literature. In conclusion, the use of fibrin sealant in the latissimus flap donor site appears to be effective in preventing seroma...
  5. ncbi The current status of tissue glues: part II. For adhesion of soft tissues
    Arun K Gosain
    Department of Plastic Surgery, Medical College of Wisconsin, Milwaukee 53226, USA
    Plast Reconstr Surg 110:1581-4. 2002
  6. ncbi The venous graft as an effector of early angiogenesis in a fibrin matrix
    E Polykandriotis
    Department of Plastic and Hand Surgery, University of Erlangen Medical Center, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Microvasc Res 75:25-33. 2008
    ..From the three segments of the vascular axis in the AV loop the IVG is the most versatile for applications in the clinical as well as the experimental setting. Kinetics of angiogenesis warrant further investigation in the IVG...
  7. ncbi Prevention of lymphorrhea by means of fibrin glue after axillary lymphadenectomy in breast cancer: prospective randomized trial
    F N Gilly
    Department of Surgery, Centre Hospitalo Universitaire Lyon Sud, Pierre Benite, France
    Eur Surg Res 30:439-43. 1998
    ..006). One delayed seroma was observed in each group. Fibrin glue seems to reduce daily postoperative drainage and hospital stay, but did not affect delayed seroma formation after axillary lymphadenectomy for breast cancer...
  8. ncbi Fibrin glue treatment of complex anal fistulas has low success rate
    Rasmy Loungnarath
    Section of Colon and Rectal Surgery, Washington University School of Medicine Barnes Jewish Hospital, St Louis, Missouri, USA
    Dis Colon Rectum 47:432-6. 2004
    ..Reported success rates vary widely. The purpose of this study was to review the use of fibrin glue in the management of complex anal fistulas at a tertiary referral center...
  9. ncbi The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC): method description and recent developments
    Jan Philipp Benthien
    Department of Orthopaedic Surgery, University of Basel, Basel, Switzerland
    Knee Surg Sports Traumatol Arthrosc 19:1316-9. 2011
    ..This technical note describes the method of autologous matrix-induced chondrogenesis (AMIC), a one-step procedure combining subchondral microfracture with the fixation of a collagen I/III membrane with fibrin glue or sutures...
  10. ncbi A new fibrin sealant from Crotalus durissus terrificus venom: applications in medicine
    L C Barros
    Centro de Estudos de Venenos e Animais Peconhentos, Universidade Estadual Paulista, UNESP, Botucatu, Sao Paulo State, Brasil
    J Toxicol Environ Health B Crit Rev 12:553-71. 2009
    ..The effectiveness of this new fibrin sealant is reviewed and its development and employment are described...
  11. ncbi Mid-term results of Autologous Matrix-Induced Chondrogenesis for treatment of focal cartilage defects in the knee
    J Gille
    Department of Orthopaedics and Trauma, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Knee Surg Sports Traumatol Arthrosc 18:1456-64. 2010
    ..However, further studies with long-term follow-up are needed to determine whether the grafted area will maintain structural and functional integrity over time...
  12. ncbi Comparison of fibrin glue versus suture for conjunctival autografting in pterygium surgery: a meta-analysis
    Hong wei Pan
    Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, China
    Ophthalmology 118:1049-54. 2011
    ..To evaluate the safety and clinical efficacy of fibrin glue in pterygium surgery with conjunctival autografting...
  13. ncbi Sutureless human sclera donor patch graft for Ahmed glaucoma valve
    Lucio Zeppa
    Unità Operativa di Oculistica, Presidio Ospedaliero Giuseppe Moscati, Avellino Italy
    Eur J Ophthalmol 20:546-51. 2010
    ..To report the safety and effectiveness of a sutureless human sclera donor patch graft covering the subconjunctival portion of glaucoma drainage implant tube to prevent its erosion throughout the overlying conjunctiva...
  14. ncbi Glued posterior chamber IOL in eyes with deficient capsular support: a retrospective analysis of 1-year post-operative outcomes
    D A Kumar
    Dr Agarwal s Eye Hospital and Eye Research Centre, Chennai, India
    Eye (Lond) 24:1143-8. 2010
    ..To evaluate the post-operative outcome of fibrin glue-assisted posterior chamber intraocular lens (IOL) implantation in eyes with deficient capsular support after 1 year...
  15. ncbi Fibrin sealant reduces the duration and amount of fluid drainage after axillary dissection: a randomized prospective clinical trial
    M Moore
    Department of Surgery and the Tissue Adhesive Center, University of Virginia, Charlottesville, USA
    J Am Coll Surg 192:591-9. 2001
    ..The viral safety of the product was also supported...
  16. ncbi Fibrin glue versus sutures for attaching the conjunctival autograft in pterygium surgery: a prospective observer masked clinical trial
    S Srinivasan
    Department of Ophthalmology, Toronto Western Hospital, Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada
    Br J Ophthalmol 93:215-8. 2009
    ..To compare the degree of conjunctival autograft inflammation, subconjunctival haemorrhage (SCH) and graft stability following the use of sutures or fibrin glue (FG) during pterygium surgery...
  17. ncbi Experience improves successful use of fibrin sealant in total knee arthroplasty: implications for surgical education
    Gwo Jaw Wang
    Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia, USA
    J Long Term Eff Med Implants 13:389-97. 2003
    ..04). The decline between the early C, 3.51 +/- 0.21 g/dL, and the early FS, 3.25 +/- 0.22 g/dL, was 0.26 g/dL (p = 0.34). This study demonstrates the importance of experience and education in successful application of tissue adhesives...
  18. ncbi Randomized clinical trial of tranexamic acid-free fibrin sealant during vascular surgical procedures
    R T A Chalmers
    Royal Infirmary of Edinburgh, Edinburgh, UK
    Br J Surg 97:1784-9. 2010
    ..This study evaluated the safety and haemostatic effectiveness of a fibrin sealant (EVICEL(™) Fibrin Sealant (Human)) during vascular surgery...
  19. ncbi A comparative study of tissue glue and vicryl suture for closing limbal-conjunctival autografts and histologic evaluation after pterygium excision
    Yasemin Ozdamar
    Ankara Ulucanlar Eye Research Hospital, Ankara, Turkey
    Cornea 27:552-8. 2008
    ..To compare clinical and histopathologic outcomes of tissue glue and vicryl suture to attach limbal conjunctival autografts in pterygium surgery...
  20. ncbi The use of fibrin glue in surgery of the knee
    S Patel
    Department of Orthopaedics, University College Hospital, 235 Euston Road, London NW1 2BU, UK
    J Bone Joint Surg Br 92:1325-31. 2010
    ..Consequently, it has the potential to be used in a number of ways in orthopaedic surgery. The purpose of this review is to address its use in surgery of the knee in which it appears to offer great promise...
  21. ncbi Watertight cataract incision closure using fibrin tissue adhesive
    John A Hovanesian
    Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, USA
    J Cataract Refract Surg 33:1461-3. 2007
    To determine whether a simple method for applying fibrin tissue adhesive to a clear corneal cataract incision can create a watertight seal.
  22. ncbi Effectiveness of autologous fibrin tissue adhesive in reducing postoperative blood loss during total hip arthroplasty: a prospective randomised study of 100 cases
    M Mawatari
    Department of Orthopaedic Surgery, Saga University, Saga City, Japan
    J Orthop Surg (Hong Kong) 14:117-21. 2006
    To evaluate the effectiveness of autologous fibrin tissue adhesive (auto-FTA) in reducing blood loss during cementless total hip arthroplasty (THA).
  23. ncbi Subconjunctival carboplatin in fibrin sealant in the treatment of transgenic murine retinoblastoma
    Kurtis R Van Quill
    Ocular Oncology Unit, Department of Ophthalmology, University of California at San Francisco, San Francisco, California 94143, USA
    Ophthalmology 112:1151-8. 2005
    ..To evaluate the efficacy of subconjunctival carboplatin in fibrin sealant in the treatment of transgenic murine retinoblastoma...
  24. ncbi A review of bioceramics and fibrin sealant
    L Le Guehennec
    INSERM EM 9903, Research Center on Materials of Biological Interest Faculty of Dental Surgery, Place Alexis Ricordeau, 44042 Nantes Cedex, France
    Eur Cell Mater 8:1-10; discussion 10-1. 2004
    ..This review discusses both the advantages and disadvantages, as well as the future perspectives, of using bioceramic-fibrin composites in various clinical indications...
  25. ncbi Post-injury regeneration in rat sciatic nerve facilitated by neurotrophic factors secreted by amniotic fluid mesenchymal stem cells
    Hung Chuan Pan
    Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan
    J Clin Neurosci 14:1089-98. 2007
    ..The increased nerve regeneration found in this study may be due to the neurotrophic factors secreted by amniotic fluid mesenchymal stem cells...
  26. ncbi The use of fibrin glue in skin grafts and tissue-engineered skin replacements: a review
    L J Currie
    Blond McIndoe Centre for Medical Research, Queen Victoria Hospital, East Grinstead, West Sussex, United Kingdom
    Plast Reconstr Surg 108:1713-26. 2001
    ..Fibrin glue has also been shown to be a suitable delivery vehicle for exogenous growth factors that may in the future be used to accelerate wound healing...
  27. ncbi Fibrin: a versatile scaffold for tissue engineering applications
    Tamer A E Ahmed
    Department of Cellular and Molecular Medicine, University of Ottawa, Ontario, Canada
    Tissue Eng Part B Rev 14:199-215. 2008
    ..Thus, fibrin is a versatile biopolymer, which shows a great potential in tissue regeneration and wound healing...
  28. pmc Fibrin glue in ophthalmology
    Anita Panda
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Indian J Ophthalmol 57:371-9. 2009
    ..The purpose of this review is to discuss the currently available information on fibrin glue...
  29. ncbi Effectiveness of a new carrier-bound fibrin sealant versus argon beamer as haemostatic agent during liver resection: a randomised prospective trial
    Andrea Frilling
    Department of General Surgery and Transplantation, University Hospital of Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Langenbecks Arch Surg 390:114-20. 2005
    ..A new carrier-bound fibrin sealant, TachoSil, is expected to be efficacious and safe as a haemostatic treatment in hepatic resection...
  30. ncbi Use of fibrin sealant to reduce bloody drainage and hemoglobin loss after total knee arthroplasty: a brief note on a randomized prospective trial
    G J Wang
    University of Virginia Health System, Charlottesville 22908, USA
    J Bone Joint Surg Am 83:1503-5. 2001
    ..A phase-III trial that included fifty-three patients undergoing unilateral primary total knee arthroplasty with cement was conducted to investigate the hemostatic efficacy of fibrin sealant...
  31. ncbi Fibrin glue as an osteoinductive protein in a mouse model
    S Abiraman
    Implant Biology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India
    Biomaterials 23:3023-31. 2002
    ..On the contrary, the uncoated granules did not show any de novo bone formation. This experimental study provides an evidence of the positive role of FG as a potential osteoinductive biologic tissue adhesive...
  32. ncbi Fibrin glue versus sutures for conjunctival autografting in pterygium surgery: a prospective comparative study
    A Karalezli
    Department of Ophthalmology, Baskent University School of Medicine, Ankara, Turkey
    Br J Ophthalmol 92:1206-10. 2008
    ..To compare the use of fibrin glue versus sutures for fixating conjunctival autografts in patients undergoing pterygium excision...
  33. ncbi Estimating the pathogen safety of manufactured human plasma products: application to fibrin sealants and to thrombin
    Bernard Horowitz
    Horowitz Consultants, LLC, Key Biscayne, Florida, USA
    Transfusion 48:1739-53. 2008
    ....
  34. ncbi Treatment of traumatic LASIK flap dislocation and epithelial ingrowth with fibrin glue
    David L Yeh
    Duke University Eye Center, Durham, NC 27710, USA
    Am J Ophthalmol 141:960-2. 2006
    ..To describe a case of a traumatic late dislocation of a laser-assisted in situ keratomileusis (LASIK) flap complicated by epithelial ingrowth...
  35. pmc Use of human fibrin glue (Tissucol) versus staples for mesh fixation in laparoscopic transabdominal preperitoneal hernioplasty: a prospective, randomized study
    Federico Lovisetto
    Dipartimento di Scienze Chirurgiche, Rianimatorie Riabilitative e dei Trapianti d Organo, Facolta di Medicina, University of Pavia, Pavia, Italy
    Ann Surg 245:222-31. 2007
    ..The aim of this study was to compare the morbidity of fixation of prosthetic meshes using Tissucol fibrin glue versus staples in laparoscopic transabdominal preperitoneal (TAPP) repair of inguinal and femoral hernias...
  36. ncbi Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis
    Peter A M Everts
    Department of Peri Operative Blood Management, Catharina Hospital, Eindhoven, The Netherlands
    Knee Surg Sports Traumatol Arthrosc 15:888-94. 2007
    ..We conclude that peri-operatively applied platelet gel and fibrin sealant may improve the range of motion after total knee arthroplasty, decreases the length of stay and may reduce the incidence of arthrofibrosis...
  37. ncbi Bulk physicochemical, interconnectivity, and mechanical properties of calcium phosphate cements-fibrin glue composites for bone substitute applications
    M A Lopez-Heredia
    Department of Biomaterials, College of Dental Science, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Biomed Mater Res A 101:478-90. 2013
    ..Moreover, 0.500 mL of long setting FG modified the observed fracture behavior of the CPC-FG...
  38. pmc Fibrin glue-assisted glaucoma drainage device surgery
    M Y Kahook
    Department of Ophthalmology, University of Colorado Health Sciences Center, Rocky Mountain Lions Eye Institute, CO 80045, USA
    Br J Ophthalmol 90:1486-9. 2006
    ..To describe the use of fibrin glue as a suture substitute for portions of glaucoma drainage device (GDD) surgery...
  39. pmc Fibrin tissue adhesive reduces postoperative blood loss in total knee arthroplasty
    Luigi Sabatini
    Orthopedics and Traumatology Department, Ospedale Civile di Saluzzo, Via Spielberg 58, 12037, Saluzzo, CN, Italy
    J Orthop Traumatol 13:145-51. 2012
    ..Blood transfusion is often required in total knee replacement; various methods of blood preservation have been studied. The best solution is to reduce the loss of blood during and after surgery...
  40. pmc Reduction of blood loss in primary hip arthroplasty with tranexamic acid or fibrin spray
    Jamie S McConnell
    Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
    Acta Orthop 82:660-3. 2011
    ..Previous studies have shown that either fibrin spray or tranexamic acid can reduce blood loss at total hip replacement, but the 2 treatments have not been directly compared. We therefore conducted a randomized, controlled trial...
  41. ncbi Clinical application of tissue adhesives in soft-tissue surgery of the head and neck
    John Yoo
    Department of Otolaryngology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, UK
    Curr Opin Otolaryngol Head Neck Surg 16:312-7. 2008
    ..To evaluate the clinical applications of tissue adhesives in soft-tissue surgery of the head and neck, and to highlight the practical and theoretical differences between the various synthetic and biologic products...
  42. ncbi Use of fibrin sealant in laparoscopic gastric bypass for the morbidly obese
    Meng G Martin Lee
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Obes Surg 14:1321-6. 2004
    ..This paper discusses the biological and clinical evidence for use of fibrin sealant in laparoscopic gastric bypass...
  43. ncbi Fatal intraoperative anaphylaxis related to aprotinin after local application of fibrin glue
    Anne Marie Oswald
    Anesthesiology 99:762-3. 2003
  44. ncbi The use of fibrin glue in plastic surgery
    Eric Mooney
    Bassett Healthcare, 38 Nelson Avenue, Cooperstown, NY 13326 1017, USA
    Plast Reconstr Surg 124:989-92. 2009
    ..This article provides an overview of fibrin glue, including its composition, mechanism of action, availability, safety, efficacy, and potential applications in plastic surgery...
  45. ncbi Applications of fibrin sealant in surgery
    Meng G Martin Lee
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Surg Innov 12:203-13. 2005
    ..The applications of fibrin sealant are expanding, and new preparations of fibrin sealant are currently being evaluated...
  46. ncbi Fibrin sealant (Tissucol) enhances tissue integration of condensed polytetrafluoroethylene meshes and reduces early adhesion formation in experimental intraabdominal peritoneal onlay mesh repair
    Alexander H Petter-Puchner
    Ludwig Boltzmann Institute for Traumatology at the Research Center of the AUVA, Cluster for Tissue Regeneration, Vienna, Austria
    J Surg Res 150:190-5. 2008
    ..It was tested whether FS application allowed the reduction of sutures for mesh fixation without increasing the risk of mesh dislocation...
  47. ncbi Intraoperative application of fibrin sealant does not reduce the duration of closed suction drainage following radical axillary lymph node dissection in melanoma patients: a prospective randomized trial in 58 patients
    Heiko Neuss
    Department of General, Visceral, Thoracic and Vascular Surgery, Medical Faculty of Humboldt University, Charite Universitaetsmedizin Berlin, Charite, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    World J Surg 32:1450-5. 2008
    ..To study the effect of intraoperatively applied fibrin sealant following RALND a randomized patient-blinded trial was carried out...
  48. ncbi Topical gentamicin does not provide any additional anastomotic strength when combined with fibrin glue
    Gokulakkrishna Subhas
    Department of Surgery, Providence Hospital and Medical Centers, Southfield, MI 48075, USA
    Am J Surg 201:339-43. 2011
    ..We evaluated the effect of a combination of fibrin sealant and topical gentamicin on a colonic anastomosis in a rat model...
  49. ncbi Role of fibrin glue in the prevention of peritoneal adhesions in ventral hernia repair
    Juan Antonio Martín-Cartes
    Surgical Department, Laparoscopic Surgery Unit, Virgen del Rocio University Hospital, c Baños 76, 41002, Seville, Spain
    Surg Today 38:135-40. 2008
    ..The aim of this study was to investigate the effects of fibrin glue on the prevention of postoperative peritoneal adhesion to prosthetic materials used in ventral hernia repair...
  50. ncbi Fibrin sealant (evicel® [quixil®/crosseal™]): a review of its use as supportive treatment for haemostasis in surgery
    Sohita Dhillon
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Drugs 71:1893-915. 2011
    ....
  51. ncbi Histological effects of fibrin glue on nervous tissue: a safety study in rats
    Joost De Vries
    Department of Neurosurgery, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Surg Neurol 57:415-22; discussion 422. 2002
    ..To verify the safety of intracranial application of fibrin glue, we investigated the histologic effects of fibrin glue on brain tissue and intracranial nerves of rats...
  52. ncbi Anastomotic sealing with a fibrin-coated collagen patch in small-diameter bowel
    Martin Chmelnik
    Division of Pediatric Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Langenbecks Arch Surg 396:685-91. 2011
    ..The aim of this study was to evaluate the complication rates and inflammatory response in TachoSil™-sealed small-diameter anastomoses with conventional and reduced suture number as a model for neonatal bowel surgery...
  53. ncbi Fibrin glue is effective healing perianal fistulas in patients with Crohn's disease
    Jean Charles Grimaud
    Hopital Nord, Centre d investigation Clinique Marseille Nord, Universite Mediterranee, Marseille, France
    Gastroenterology 138:2275-81, 2281.e1. 2010
    ..We assessed the efficacy and safety of a heterologous fibrin glue that was injected into the fistula tracts of patients with Crohn's disease (ClinicalTrials.gov No. NCT00723047)...
  54. ncbi Hemostatic effectiveness of Fibrin pad after partial nephrectomy in swine
    Richard W Hutchinson
    Ethicon, Inc, a Johnson and Johnson Company, Somerville, New Jersey 08876 0151, USA
    J Surg Res 167:e291-8. 2011
    ..In this model, severe bleeding can be managed by concurrent use of several currently available treatments, or a more convenient option that offers performance and safety advantages...
  55. ncbi A prospective randomized trial: the influence of intraoperative application of fibrin glue after radical inguinal/iliacal lymph node dissection on postoperative morbidity
    H Neuss
    Department of General, Visceral, Thoracic and Vascular Surgery, Charite, Universitaetsmedizin Berlin, Charite, Campus Mitte, Berlin, Germany
    Eur J Surg Oncol 35:884-9. 2009
    ..To detect whether fibrin glue application results in a decreased lymphatic secretion following RILND a randomized patient blinded clinical trial was conducted...
  56. ncbi Fibrin glue as a sealant for high-risk anastomosis in surgery for morbid obesity
    Carson D Liu
    University of California, Los Angeles School of Medicine and Greater Los Angeles VA Medical Center, Department of Surgery, Los Angeles, CA 10833, USA
    Obes Surg 13:45-8. 2003
    ..Fibrin sealant, Tisseel, was used by one surgeon on 120 consecutive patients at the gastrojejunal anastomosis in Roux-en-Y gastric bypass (RYGBP). We hypothesized that the application of fibrin sealant would decrease anastomotic leaks...
  57. pmc Fibrin sealant does not decrease seroma output or time to drain removal following inguino-femoral lymph node dissection in melanoma patients: a randomized controlled trial (NCT00506311)
    Melinda M Mortenson
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    World J Surg Oncol 6:63. 2008
    ....
  58. ncbi Anastomotic leakage after laparoscopic resection of rectal cancer: the impact of fibrin glue
    Jung Wook Huh
    Department of Surgery, Chonnam National University, Hwasun Hospital and Medical School, Gwangju, Korea
    Am J Surg 199:435-41. 2010
    ..The aim of this study was to evaluate whether the use of fibrin glue as a sealant over an anastomosis is a risk factor for anastomotic leakage after laparoscopic rectal cancer surgery...
  59. pmc Comments on using fibrin glue in pterygium surgery
    L S Alvarenga
    Br J Ophthalmol 89:392; author reply 392. 2005
  60. ncbi Haemostatic sealants in nephron-sparing surgery: what surgeons need to know
    Orietta Dalpiaz
    Department of Urology, Medical University Innsbruck, Innsbruck, Austria
    BJU Int 102:1502-8. 2008
    ..They should not be viewed as an alternative, but as complementary agents to be used to improve surgical outcomes. Further prospective studies are necessary to validate their role in relation to other haemostatic support techniques...
  61. ncbi Anastomotic leak prophylaxis using a vapor-heated fibrin sealant: report on 738 gastric bypass patients
    James A Sapala
    Harper University Hospital, the Detroit Medical Center and Centers for Obesity Related Illness CORI, Detroit, MI, USA
    Obes Surg 14:35-42. 2004
    ..Therefore, we designed a 2-year, prospective study to determine the therapeutic efficacy of vapor-heated fibrin sealant to prevent anastomotic leaks at the gastro-jejunostomy (GJS) site...
  62. ncbi Fibrin glue in the endoscopic treatment of fistulae and anastomotic leakages of the gastrointestinal tract
    Elisabeth Lippert
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Int J Colorectal Dis 26:303-11. 2011
    ..However, patients often are severely ill and endoscopic therapeutic options have been suggested to avoid surgical intervention...
  63. ncbi A fibrin glue composition as carrier for nucleic acid vectors
    Ulrike Schillinger
    Institute of Experimental Oncology, Technische Universitat Munchen, Munich, Germany
    Pharm Res 25:2946-62. 2008
    ..The purpose of this study was to generate a gene vector-doted fibrin glue as a versatile injectable implant to be used in gene therapy supported tissue regeneration...
  64. ncbi Autologous human fibrin glue in multilayered amniotic membrane transplantation
    Altan Atakan Ozcan
    Cukurova University School of Medicine, Department of Ophthalmology, 01330 Balcali, Adana Turkey
    Ann Ophthalmol (Skokie) 40:107-9. 2008
    ..Defective epithelium of descemetocele was removed; separate and multilayered amniotic membranes were transplanted using autologous human fibrin glue. Finally a large amnion at the top was sutured on the cornea...
  65. ncbi Fibrin tissue-filler glue for persistent epithelial defects
    Peter M Sumich
    Clin Experiment Ophthalmol 31:267-9. 2003
  66. ncbi [Fibrin glue for closing conjunctival wounds in ophthalmic surgery]
    T Krzizok
    Zentrum für Augenheilkunde, Justus Liebig Universitat, Giessen
    Ophthalmologe 101:1006-10. 2004
    ..We examined the ability of fibrin glue--instead of sutures--to close conjunctival wounds at the end of different ophthalmic surgeries...
  67. ncbi Fibrin glue-assisted augmented amniotic membrane transplantation for the treatment of large noninfectious corneal perforations
    Hong Kyun Kim
    Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, South Korea
    Cornea 28:170-6. 2009
    ..To evaluate and report the efficacy of fibrin glue (FG)-assisted augmented amniotic membrane transplantation (AMT) in patients with large corneal perforations...
  68. ncbi Advances in the use of adhesives in ophthalmology
    Stanley M Chan
    Cornea Service, Hopital Maisonneuve Rosemont, University of Montreal, Montreal, Quebec, Canada
    Curr Opin Ophthalmol 15:305-10. 2004
    ..To summarize the known uses of available medical tissue adhesives in the management of diseases of the anterior segment, highlighting recent developments in the field...
  69. ncbi Effect of fibrin glue on lymphatic drainage and on drain removal time after modified radical mastectomy: a prospective randomized study
    Ali Naki Ulusoy
    Department of Surgery, Ondokuz Mayis University School of Medicine, Samsun, Turkey
    Breast J 9:393-6. 2003
    ..05). In conclusion; fibrin glue application had no significant benefit on axillary lymphatic drainage, drain removal time, or seroma formation...
  70. ncbi Fibrin glue versus N-butyl-2-cyanoacrylate in corneal perforations
    Ashok Sharma
    Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
    Ophthalmology 110:291-8. 2003
    ..To compare the efficacy of fibrin glue and N-butyl-2-cyanoacrylate in corneal perforations...
  71. ncbi Mechanical quality of tissue engineered cartilage: results after 6 and 12 weeks in vivo
    G N Duda
    Charite, Campus Virchow Klinikum, Humboldt University of Berlin, Augustenburger Platz 1, D 13353 Berlin, Germany
    J Biomed Mater Res 53:673-7. 2000
    ..As an adjunct to histological analysis, mechanical testing may be a valuable tool for judging the utility of engineered cartilage prior to a broad clinical usage...
  72. ncbi Fibrin sealant: past, present, and future: a brief review
    William D Spotnitz
    Department of Surgery, Surgical Therapeutic Advancement Center, University of Virginia Health System, P O Box 801370, Charlottesville, VA, 22908 1370, USA
    World J Surg 34:632-4. 2010
    ....
  73. ncbi Impact of manufacturing, irradiation and filtration steps to bacterial contamination of autologous fibrin sealant
    Christoph Buchta
    Department for Blood Group Serology and Transfusion Medicine, Vienna Medical University, Vienna, Austria
    Biologicals 32:165-9. 2004
    ..Especially in the orthopaedic setting, application of contaminated fibrin sealant can cause severe infections...
  74. ncbi Comparison of a new fibrin sealant with standard topical hemostatic agents
    Myron Schwartz
    Department of Surgery, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Surg 139:1148-54. 2004
    ..Fibrin sealants represent an improvement over conventional topical hemostatic agents, because they contain components that actively form clot. However, most available agents contain nonhuman protein, which represents an immunologic risk...
  75. ncbi Human amniotic membrane transplantation with fibrin glue in management of primary pterygia: a new tuck-in technique
    Arun K Jain
    Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    Cornea 27:94-9. 2008
    ..To report the use of fibrin glue for attaching the human amniotic membrane graft with a tuck-in technique after primary pterygium excision...
  76. ncbi Systematic review and meta-analysis of the use of fibrin sealant to prevent seroma formation after breast cancer surgery
    P A Carless
    Discipline of Clinical Pharmacology, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
    Br J Surg 93:810-9. 2006
    ..The use of fibrin sealant has been proposed as a means of preventing seroma formation following breast cancer surgery. Conflicting trial results require the efficacy of fibrin sealant to be reviewed critically...
  77. ncbi Fibrin glue for fistula-in-ano: the evidence reviewed
    M T Swinscoe
    Academic Surgical Unit, Level 8, Clinical Sciences Building St James s University Hospital, Leeds LS9 7TF, United Kingdom
    Tech Coloproctol 9:89-94. 2005
    ..The quality of data to assess the efficacy of fibrin glue in the treatment of anal fistulae is poor and further clinical trials are needed. Fistula complexity is the main factor that adversely influences long-term healing rates...
  78. ncbi Human fibrin tissue adhesive for sutureless lamellar keratoplasty and scleral patch adhesion: a pilot study
    Herbert E Kaufman
    Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Ophthalmology 110:2168-72. 2003
    ..To determine whether a fibrin adhesive can facilitate the performance of sutureless lamellar keratoplasty and attachment of amnion to bare sclera...
  79. ncbi Tissue glue in sutureless vitreoretinal surgery for the treatment of wound leakage
    Cosar Batman
    Department of Vitreoretinal Surgery, Ankara Ulucanlar Eye Research Hospital, Ankara, Turkey
    Ophthalmic Surg Lasers Imaging 39:100-6. 2008
    ..To assess the surgical outcomes of the use of tissue glue to close sclerotomy sites when required and the views of ultrasound biomicroscopy of the sclerotomy sites in 23- and 25-gauge vitrectomy systems...
  80. ncbi Comparison of fibrin glue with sutures for pterygium excision surgery with conjunctival autografts
    Reece C Hall
    Ophthalmology Department, Wellington Hospital, Capital Coast District Health Board, Wellington, New Zealand
    Clin Experiment Ophthalmol 37:584-9. 2009
    ..To compare pterygium excision conjunctival autograft surgery using Tisseel fibrin glue versus Vicryl sutures...
  81. ncbi Platelet-rich plasma and platelet gel: a review
    Peter A M Everts
    Department of Extra Corporeal Blood Management, Catharina Hospital, Eindhoven, The Netherlands
    J Extra Corpor Technol 38:174-87. 2006
    ..This review addresses a large variety of aspects relevant to platelets, platelet-rich plasma, and the application of platelet gel. In addition, an overview of recent animal and human studies is presented...
  82. ncbi Comparison of fibrin sealant and sutures for conjunctival autograft fixation in pterygium surgery: one-year follow-up
    Jin Jiang
    Eye Center, Affiliated Second Hospital, College of Medicine, Zhejiang University, Hangzhou, China
    Ophthalmologica 222:105-11. 2008
    ..To evaluate the efficacy and safety of fibrin sealant in conjunctival autograft fixation in pterygium surgery...
  83. ncbi Safety and efficacy of currently available fibrin tissue adhesives
    K H Siedentop
    Department of Otolaryngology-Head and Neck Surgery, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA
    Am J Otolaryngol 22:230-5. 2001
    ..bonding power, preparation time, and costs associated with currently available autologous and homologous fibrin tissue adhesive preparations...
  84. ncbi Use of human fibrin glue and amniotic membrane transplant in corneal perforation
    B Duchesne
    Department of Ophthalmology, CHU Sart Tilman, University of Liege, Belgium
    Cornea 20:230-2. 2001
    ..To repair corneal perforation using human fibrin glue (HFG) and amniotic membrane transplant (AMT)...
  85. ncbi A prospective, randomized trial evaluating the safety and efficacy of fibrin sealant in tubeless percutaneous nephrolithotomy
    Hemendra N Shah
    R G Stone Urological Research Institute, Khar W, and Tata Memorial Hospital, 21 A, 14 A Road, Ahimsa Marg, Mumbai 400052, India
    J Urol 176:2488-92; discussion 2492-3. 2006
    ..We performed a prospective, randomized trial to assess the safety and efficacy of fibrin sealant in tubeless percutaneous nephrolithotomy...
  86. pmc Sutureless amniotic membrane transplantation for partial limbal stem cell deficiency
    Ahmad Kheirkhah
    Ocular Surface Center, Miami, Florida 33173, USA
    Am J Ophthalmol 145:787-94. 2008
    ..To evaluate the results of sutureless amniotic membrane (AM) transplantation using fibrin glue for reconstructing corneal surfaces with partial limbal stem cell deficiency (LSCD)...
  87. ncbi State-of-the-art review: Hemostats, sealants, and adhesives II: Update as well as how and when to use the components of the surgical toolbox
    William D Spotnitz
    Surgical Therapeutic Advancement Center, Department of Surgery, University of Virginia Health System, PO Box 801370, Charlottesville, VA 22908, USA
    Clin Appl Thromb Hemost 16:497-514. 2010
    ..Recommendations with respect to how and when to best use these materials will be presented. A review of the recent literature is also provided with respect to the most recent uses of these materials in specific surgical specialties...
  88. ncbi Amniotic membrane transplantation with fibrin glue for conjunctivochalasis
    Ahmad Kheirkhah
    Ocular Surface Center, Miami, FL 33173, USA
    Am J Ophthalmol 144:311-3. 2007
    ..To evaluate the feasibility of performing sutureless amniotic membrane transplantation (AMT) using fibrin glue for conjunctivochalasis...
  89. ncbi Fibrin glue-antibiotic mixture in the treatment of anal fistulae: experience with 69 cases
    L Patrlj
    Department of Abdominal Surgery, University Hospital Merkur, Zagreb, Republic of Croatia
    Dig Surg 17:77-80. 2000
    ..To investigate the potential value of the use of the fibrin glue-antibiotic mixture in the treatment of anal fistulae...
  90. ncbi A randomized, controlled trial of fibrin glue vs. conventional treatment for anal fistula
    Ian Lindsey
    Department of Colorectal Surgery, John Radcliffe Hospital, Oxford, United Kingdom
    Dis Colon Rectum 45:1608-15. 2002
    ..We aimed to compare the outcomes of patients with low and high anal fistulas randomly assigned to either fibrin glue or conventional treatment...
  91. ncbi The effect of sealing with a fixed combination of collagen matrix-bound coagulation factors on the healing of colonic anastomoses in experimental high-risk mice models
    Dimitrios Pantelis
    Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rheinische Friedrich Wilhelms University Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Langenbecks Arch Surg 395:1039-48. 2010
    ....
  92. ncbi Sutureless lamellar keratoplasty: a modified approach for fibrin glue application
    Maria Cecília Barros Duarte
    Duke University Medical Center, Duke University Eye Center, Durham, NC 27710, USA
    Cornea 26:1127-8. 2007
    ..To report a case where fibrin glue was applied with a modified approach to secure the graft to the host bed in lamellar keratoplasty...
  93. ncbi Reduction in bile leaks following adult split liver transplant using a fibrin-collagen sponge: A pilot study
    Luca Toti
    Queen Elizabeth Hospital, Birmingham, UK
    Dig Liver Dis 42:205-9. 2010
    ..We compared surgical complications in patients who had the cut surface of the donor liver treated with a patch to those in whom the cut surface of the liver was treated with fibrin glue...
  94. ncbi Fibrin glue mixed with gelatin/hyaluronic acid/chondroitin-6-sulfate tri-copolymer for articular cartilage tissue engineering: the results of real-time polymerase chain reaction
    Cheng Hung Chou
    Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei 100, Taiwan
    J Biomed Mater Res A 82:757-67. 2007
    ..The evidence could support that GHC6S-fibrin glue would be a promising scaffold for articular cartilage tissue engineering...
  95. ncbi Fibrin glue for anal fistulas: long-term results
    Stephen M Sentovich
    Section of Colon and Rectal Surgery, Department of Surgery, Boston University School of Medicine, Boston, MA, USA
    Dis Colon Rectum 46:498-502. 2003
    ..The aim of this study was to evaluate the long-term success and complication rate of fibrin-glue treatment of anal fistulas...
  96. ncbi Fibrin glue in the management of anal fistulae
    T M Hammond
    Centre for Academic Surgery, Institute of Cell and Molecular Science, Barts and The London, Queen Mary School of Medicine and Dentistry, London, UK
    Colorectal Dis 6:308-19. 2004
    ..The objective of this review was to ascertain the role of fibrin glue in the management of anal fistulae, including assessment of recurrence rates, continence disturbance and other complications...
  97. ncbi The contribution of platelets in the production of cryoprecipitates for use in a fibrin glue
    G Rock
    The University of Ottawa, Ottawa, ON, Canada
    Vox Sang 91:252-5. 2006
    ..Cryoprecipitate has a wide application for use as a fibrin glue. In some situations, platelets are added to the preparation in order to enhance the fibrin glue...
  98. ncbi Fibrin glues of human origin
    Mauro Valbonesi
    Department of Immunohematology, San Martino University Hospital, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Best Pract Res Clin Haematol 19:191-203. 2006
    ..Instead of more new technologies, larger studies are now needed to quantify the benefits and clarify the optimal application for these products...
  99. ncbi [Fistulas and fissures. Part I: perianal fistulas]
    W Heitland
    Klinikum Bogenhausen, Klinik für Visceral, Thorax und Gefasschirurgie, Städtisches Klinikum München GmbH, Englschalkinger Strasse 77, 81925 Munchen
    Chirurg 79:430-8. 2008
    ..Excision of the external fistula tract, closure of the internal opening, and a local advancement flap are now competing with fistulotomy, curettage, and immediate reconstruction...
  100. ncbi Role of conjunctival inflammation in surgical outcome after amniotic membrane transplantation with or without fibrin glue for pterygium
    Ahmad Kheirkhah
    Ocular Surface Center, Miami, FL 33173, USA
    Cornea 27:56-63. 2008
    ..To determine the clinical significance of postoperative conjunctival inflammation noted at the third or fourth week after intraoperative application of mitomycin C and amniotic membrane transplantation for pterygium...
  101. ncbi Fistula-in-ano: advances in treatment
    Samer Deeba
    Department of Biosurgery and Surgical Technology, St Mary s Hospital, Norfolk Place, London W2 1NY, UK
    Am J Surg 196:95-9. 2008
    ..This review summarizes the history of fistula-in-ano management, the current techniques available, and describes new technologies...

Research Grants27

  1. Synovium-based articular cartilage tissue engineering
    Ernst B Hunziker; Fiscal Year: 2010
    ..We believe that this project is highly innovative and that the results of this research will have a significant impact on the future treatment of osteoarthritic lesions and on improvement of the health status of the US population. ..
  2. Clinical Development of Hemostatic Agent ClotFoam for Severe Hemorrhage
    Maja Nowakowski; Fiscal Year: 2013
    ..Substantial economic activity will be generated from the global provision of this core component. ..
  3. Transscleral Drug Delivery for Retinal Disorders
    HENRY FRANCIS EDELHAUSER; Fiscal Year: 2010
    ..These delivery techniques should be safer and more effective than the state of the art. Ultimately, these results will guide us in enhancing drug treatments in ophthalmic practice. ..
  4. Reducing Mortality from Acute Hemorrhage in Trauma
    RHONDA K COOKE; Fiscal Year: 2012
    ..Reducing death from acute hemorrhage in trauma care will be a major step forward in reducing overall trauma mortality. ..
  5. CLOTTING FACTORS FROM FISH BLOOD FOR FIBRIN SEALANTS
    Evelyn Sawyer; Fiscal Year: 2000
    ..The U.S. market is over $400 million, in addition to military use. ..
  6. DEVELOPMENT OF A FIBRIN SEALANT DELIVERY METHOD
    BRENDA MORSE; Fiscal Year: 1991
    ..The objective of this study is to develop and evaluate a unique method for the mixing and delivery of fibrin sealant in a single syringe or container system...
  7. Responses to Surgical and Bronchoscopic Volume Reduction
    Edward Ingenito; Fiscal Year: 2006
    ..We believe that by accomplishing these objectives, we can help advance this technology into the clinical arena. ..
  8. CHARACTERIZATION OF FIBRIN SEALANT FORMULATIONS
    EDWARD LUCK; Fiscal Year: 1992
    ....
  9. Wayne State University Clinical Translational Science
    Michael Diamond; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  10. 8th Conference - Chemistry & Biology Mineralized Tissue
    WILLIAM LANDIS; Fiscal Year: 2004
    ....
  11. Effect of Diabetes on Bone Integration of Implants
    Michael McCracken; Fiscal Year: 2002
    ..This knowledge may lead to bioengineered materials which will modify and improve bone healing response in diabetic patients who receive implants. ..
  12. OCULAR HERPES SIMPLEX
    Herbert Kaufman; Fiscal Year: 2008
    ..If they are additive to or synergistic with acyclovir in suppressing viral DNA production, tests on human infection could almost certainly follow. [unreadable] [unreadable] [unreadable]..
  13. CORE GRANT FOR VISION RESEARCH
    Herbert Kaufman; Fiscal Year: 2008
    ..This Core Grant has [unreadable] been a vital force in keeping vision research highly active at LSU for the past 25 years, and we hope that it will continue to serve this function in the future. [unreadable] [unreadable]..
  14. Fibronectin peptides for treatment of burns
    Richard Clark; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  15. MINERAL-MATRIX RELATIONS IN CALCIFYING TISSUES
    WILLIAM LANDIS; Fiscal Year: 2006
    ....
  16. Systematic Integration POR into Clinical Pathway of HCC
    Myron Schwartz; Fiscal Year: 2006
    ..This program provides a truly remarkable opportunity to make meaningful progress in understanding, preventing and treating HCC, while in the process providing fertile training ground for young physician-scientists. ..
  17. HOMOCYSTEINE AND PROGRESSION OF ATHEROSCLEROSIS
    Lloyd Taylor; Fiscal Year: 2002
    ..abstract_text> ..
  18. Periodontal Disease and Rheumatoid Arthritis
    Michael McCracken; Fiscal Year: 2005
    ..Furthermore, it is hypothesized that among patients with rheumatoid arthritis, an association exists between the rate of progression of inflammatory arthritis and the progression of periodontal disease. ..
  19. Chitosan hemostatic device for laparoscopic applications
    Hua Xie; Fiscal Year: 2005
    ..abstract_text> ..
  20. Regulation of Fibroblast Survival in the Collagen Matrix
    Mark Carlson; Fiscal Year: 2005
    ..Loss of matrix anchorage is hypothesized to reverse these effects and induce apoptosis. The involvement of each protein will be probed with mutated isoforms. ..
  21. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2007
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  22. Enriched IVIG for the treatment of West Nile Virus
    Israel Nur; Fiscal Year: 2005
    ..In the absence of sufficient WN antibodies in convalescent donors, hyper-immune donors treated with an attenuated vaccine may be explored as an alternative source of plasma. ..
  23. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2004
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  24. DERIVATIZED HYALURONAN FOR WOUND HEALING
    Richard Clark; Fiscal Year: 2001
    ..Finally it will be determined whether hyaluronan constructs that are optimal in vitro for cell migration are also optimal in vivo for cutaneous wound healing. ..
  25. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2003
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..