orosomucoid

Summary

Top Publications

  1. ncbi The acute phase protein alpha1-acid glycoprotein: a model for altered glycosylation during diseases
    Fabrizio Ceciliani
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Universita di Milano, Sezione di Patologia Generale e Parassitologia, Via Celoria 10 20133, Milano, Italy
    Curr Protein Pept Sci 8:91-108. 2007
  2. pmc α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice
    Fernando Spiller
    Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Diabetes 61:1584-91. 2012
  3. ncbi Alpha(1)-acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties
    Tino Hochepied
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, Ghent University, KL Ledeganckstraat 35, Belgium
    Cytokine Growth Factor Rev 14:25-34. 2003
  4. ncbi Detailed structural features of glycan chains derived from alpha1-acid glycoproteins of several different animals: the presence of hypersialylated, O-acetylated sialic acids but not disialyl residues
    Miyako Nakano
    Faculty of Pharmaceutical Sciences, Kinki University, Kowakae 3 4 1, Higashi Osaka 577 8502, Japan
    Glycobiology 14:431-41. 2004
  5. ncbi Increased urinary orosomucoid excretion: a proposed marker for inflammation and endothelial dysfunction in patients with type 2 diabetes
    M S Christiansen
    Department of Clinical Biochemistry, Amager Hospital, Copenhagen, Denmark
    Scand J Clin Lab Invest 69:272-81. 2009
  6. pmc Structure and expression of the genes coding for human alpha 1-acid glycoprotein
    L Dente
    European Molecular Biology Laboratory, Heidelberg, FRG
    EMBO J 6:2289-96. 1987
  7. ncbi Increased urinary excretion of orosomucoid is a risk predictor of diabetic nephropathy
    Hongjuan Jiang
    Department of Nephrology, the Second Hospital of Shandong University, Jinan, China
    Nephrology (Carlton) 14:332-7. 2009
  8. ncbi Parallel increase in urinary excretion rates of immunoglobulin G, ceruloplasmin, transferrin, and orosomucoid in normoalbuminuric type 2 diabetic patients
    Takuma Narita
    Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University School of Medicine, Akita, Japan
    Diabetes Care 27:1176-81. 2004
  9. ncbi Early aldosterone-regulated genes in cardiomyocytes: clues to cardiac remodeling?
    Geza Fejes-Toth
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, New Hampshire 03756 0001, USA
    Endocrinology 148:1502-10. 2007
  10. ncbi Increased urinary orosomucoid excretion predicts preeclampsia in pregnant women with pregestational type 1 diabetes
    M S Christiansen
    Department of Clinical Biochemistry and Department of Medicine, Amager Hospital, Italiensvej 1, Copenhagen S, Denmark
    Diabetes Res Clin Pract 89:16-21. 2010

Research Grants

  1. Mechanism of sgk action in the collecting duct
    Geza Fejes Toth; Fiscal Year: 2005
  2. Eosinophil ORMDL3 and allergic inflammation
    P Sriramarao; Fiscal Year: 2012
  3. CHADSS: Chagas Disease Scan Study
    Jamary Oliveira-Filho; Fiscal Year: 2013
  4. LOCATION OF PORE SYSTEMS IN CAPILLARY WALLS
    George Palade; Fiscal Year: 2000
  5. LUNG CAPILLARY PERMEABILITY WITH HIGH VASCULAR PRESSURES
    Mary Townsley; Fiscal Year: 1991
  6. Pharmacogenetics of Methadone
    C Devane; Fiscal Year: 2003
  7. GENETIC LINKAGE STUDY OF ALCOHOLISM
    Raymond Crowe; Fiscal Year: 1993
  8. DIABETES AND CARDIOVASCULAR RISK IN MEXICO CITY
    Michael Stern; Fiscal Year: 2000
  9. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
  10. PHEROMONES--IDENTIFICATION/BIOCHEMICAL STUDIES
    Milos Novotny; Fiscal Year: 2001

Detail Information

Publications274 found, 100 shown here

  1. ncbi The acute phase protein alpha1-acid glycoprotein: a model for altered glycosylation during diseases
    Fabrizio Ceciliani
    Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Universita di Milano, Sezione di Patologia Generale e Parassitologia, Via Celoria 10 20133, Milano, Italy
    Curr Protein Pept Sci 8:91-108. 2007
    ..A critical evaluation of the impact of different AGP glycoforms on both its transport and anti-inflammatory features, and how the modifications of the glycan pattern can be utilized in clinical biochemistry, is also discussed...
  2. pmc α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice
    Fernando Spiller
    Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Diabetes 61:1584-91. 2012
    ..Together, these data suggest that AGP may be involved in reduction of neutrophil migration and increased susceptibility to sepsis in diabetic mice...
  3. ncbi Alpha(1)-acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties
    Tino Hochepied
    Department for Molecular Biomedical Research, Flanders Interuniversity Institute for Biotechnology, Ghent University, KL Ledeganckstraat 35, Belgium
    Cytokine Growth Factor Rev 14:25-34. 2003
    ..In vivo, AGP clearly has protective effects in several models of inflammation. Here we review the data supporting an anti-inflammatory and immunomodulating role of AGP...
  4. ncbi Detailed structural features of glycan chains derived from alpha1-acid glycoproteins of several different animals: the presence of hypersialylated, O-acetylated sialic acids but not disialyl residues
    Miyako Nakano
    Faculty of Pharmaceutical Sciences, Kinki University, Kowakae 3 4 1, Higashi Osaka 577 8502, Japan
    Glycobiology 14:431-41. 2004
    ..Furthermore the major sialic acid in these carbohydrate chains was N-glycolylneuraminic acid. It should be noted that these sialic acids are attached to multiple sites of the core oligosaccharide and are not present as disialyl groups...
  5. ncbi Increased urinary orosomucoid excretion: a proposed marker for inflammation and endothelial dysfunction in patients with type 2 diabetes
    M S Christiansen
    Department of Clinical Biochemistry, Amager Hospital, Copenhagen, Denmark
    Scand J Clin Lab Invest 69:272-81. 2009
    In a previous study, urinary orosomucoid excretion rate (UOER) independently predicted cardiovascular mortality in patients with type 2 diabetes...
  6. pmc Structure and expression of the genes coding for human alpha 1-acid glycoprotein
    L Dente
    European Molecular Biology Laboratory, Heidelberg, FRG
    EMBO J 6:2289-96. 1987
    ..Using Hep3B hepatoma cells as a model system for the in vitro study of the acute phase reaction, we show that only AGP-A is strongly induced by treatment with culture medium of LPS stimulated monocytes...
  7. ncbi Increased urinary excretion of orosomucoid is a risk predictor of diabetic nephropathy
    Hongjuan Jiang
    Department of Nephrology, the Second Hospital of Shandong University, Jinan, China
    Nephrology (Carlton) 14:332-7. 2009
    ..Identification of the risk predictor of diabetic nephropathy (DN) remains a major challenge currently. Thus, proteomic approaches to identify DN-related biomarker were performed...
  8. ncbi Parallel increase in urinary excretion rates of immunoglobulin G, ceruloplasmin, transferrin, and orosomucoid in normoalbuminuric type 2 diabetic patients
    Takuma Narita
    Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University School of Medicine, Akita, Japan
    Diabetes Care 27:1176-81. 2004
    ..molecular radii <55 A and different isoelectric points (pI), such as IgG, ceruloplasmin, transferrin, and orosomucoid, have been independently reported to precede the development of microalbuminuria in diabetic patients...
  9. ncbi Early aldosterone-regulated genes in cardiomyocytes: clues to cardiac remodeling?
    Geza Fejes-Toth
    Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, New Hampshire 03756 0001, USA
    Endocrinology 148:1502-10. 2007
    ..acid synthase-2), signaling, and regulation of vascular tone (RGS2, adrenomedullin) and inflammation (orosomucoid). Protein synthesis inhibitors did not prevent aldosterone induction of these genes...
  10. ncbi Increased urinary orosomucoid excretion predicts preeclampsia in pregnant women with pregestational type 1 diabetes
    M S Christiansen
    Department of Clinical Biochemistry and Department of Medicine, Amager Hospital, Italiensvej 1, Copenhagen S, Denmark
    Diabetes Res Clin Pract 89:16-21. 2010
    We evaluated the urinary orosomucoid excretion (UOE) as a biomarker of preeclampsia and preterm delivery in pregnant women with type 1 diabetes.
  11. ncbi Orosomucoid in urine predicts cardiovascular and over-all mortality in patients with Type II diabetes
    Merete S Christiansen
    Department of Clinical Biochemistry, Amager Hospital, Italiensvej 1, DK 2300 Copenhagen S, Denmark
    Diabetologia 45:115-20. 2002
    Urinary orosomucoid excretion rate is increased in a substantial proportion of patients with Type II (non-insulin-dependent) diabetes mellitus and normal urinary albumin excretion rate...
  12. ncbi Human alpha-1-glycoprotein and its interactions with drugs
    Z H Israili
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Drug Metab Rev 33:161-235. 2001
    ..It can be predicted that in the future, rapid automatic methods to measure binding to albumin and/or AAG will routinely be used in drug development and in clinical practice to predict and/or guide therapy...
  13. ncbi The peripheral benzodiazepine receptor ligand PK11195 binds with high affinity to the acute phase reactant alpha1-acid glycoprotein: implications for the use of the ligand as a CNS inflammatory marker
    Andrew Lockhart
    GlaxoSmithKline, Translational Medicine and Technology, Addenbrooke s Centre for Clinical Investigation, Addenbrooke s Hospital, Cambridge CB2 2GG, UK
    Nucl Med Biol 30:199-206. 2003
    ..Finally, local synthesis of AGP at the site of brain injury may contribute the pattern of [(11)C]PK11195 binding observed in neuroinflammatory diseases...
  14. pmc Protection by alpha 1-acid glycoprotein against tumor necrosis factor-induced lethality
    C Libert
    Laboratory of Molecular Biology, University of Gent, Belgium
    J Exp Med 180:1571-5. 1994
    ..The known platelet aggregation-inhibitory activity of alpha 1-acid glycoprotein provides a possible explanation for this protective capacity...
  15. ncbi Orosomucoid has a cAMP-dependent effect on human endothelial cells and inhibits the action of histamine
    J Sorensson
    Department of Physiology, Goteborg University, SE 405 30 Goteborg, Sweden
    Am J Physiol Heart Circ Physiol 278:H1725-31. 2000
    The plasma protein orosomucoid (alpha(1)-acid glycoprotein) has previously been shown to constitute a critical component of the capillary barrier...
  16. ncbi Multilectin assay for detecting fibrosis-specific glyco-alteration by means of lectin microarray
    Atsushi Kuno
    Research Center for Medical Glycoscience RCMG, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Clin Chem 57:48-56. 2011
    ..We therefore developed a compatible multiple lectin-antibody sandwich immunoassay on the basis of the results obtained by the lectin microarray analysis for monitoring fibrosis...
  17. ncbi Mass spectrometric and linear discriminant analysis of N-glycans of human serum alpha-1-acid glycoprotein in cancer patients and healthy individuals
    Timea Imre
    Institute of Structural Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Budapest, Pusztaszeri u 59 67, Hungary
    J Proteomics 71:186-97. 2008
    ..The pilot study presented here demonstrates that mass spectrometry combined with linear discriminant analysis (LDA) may provide valuable data for identifying and studying the pathophysiology of malignant diseases...
  18. ncbi The glomerular endothelial cell coat is essential for glomerular filtration
    Vincent Fridén
    Department of Molecular and Clinical Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
    Kidney Int 79:1322-30. 2011
    ..One of these proteins, orosomucoid, has previously been shown to be important for capillary permselectivity...
  19. pmc Systemic inflammation in cardiovascular and periodontal disease: comparative study
    Ingrid Glurich
    Department of Oral Biology, State University of New York at Buffalo, 14214, USA
    Clin Diagn Lab Immunol 9:425-32. 2002
    ..The data support the hypothesis that localized persistent infection may influence systemic levels of inflammatory mediators. Changes in inflammatory mediator levels potentially impact inflammation-associated atherosclerotic processes...
  20. ncbi Glycosylation of site-specific glycans of alpha1-acid glycoprotein and alterations in acute and chronic inflammation
    Koji Higai
    Department of Clinical Chemistry, School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274 8510, Japan
    Biochim Biophys Acta 1725:128-35. 2005
    ..We investigated alteration of N-glycans at each of glycosylation sites of AGP in the sera of patients with acute and chronic inflammation...
  21. ncbi CSF and serum orosomucoid (alpha-1-acid glycoprotein) in patients with multiple sclerosis: a comparison among particular subgroups of MS patients
    Pavel Adam
    Laboratory of Reference for CSF and Neuroimmunology, Department of Clinical Biochemistry, Immunology and Haematology, Homolka Hospital, Prague, Czech Republic
    Clin Chim Acta 334:107-10. 2003
    To compare cerebrospinal fluid (CSF) and serum orosomucoid (alpha-1-acid glycoprotein-AAG) concentrations in various subgroups of patients with multiple sclerosis (MS).
  22. ncbi Α₁-acid glycoprotein modulates phagocytosis and killing of Escherichia coli by bovine polymorphonuclear leucocytes and monocytes
    Cristina Lecchi
    Universita degli Studi di Milano, Dipartimento di Patologia Animale, Igiene e Sanita Pubblica Veterinaria, Via Celoria 10, 20133 Milano, Italy
    Vet J 196:47-51. 2013
    ..coli by PMNs was reduced following dephosphorylation. The findings indicate that the functions of PMNs and monocytes are differentially regulated by varying concentrations of AGP and its phosphorylation state...
  23. pmc Acute-phase protein alpha-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism
    F L A C Mestriner
    Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Proc Natl Acad Sci U S A 104:19595-600. 2007
    ..These data demonstrate that AGP, an acute-phase protein, inhibits neutrophil migration by an NO-dependent process and suggest that AGP also participates in human sepsis...
  24. ncbi Beneficial effects of orosomucoid on the glomerular barrier in puromycin aminonucleoside-induced nephrosis
    Clara Hjalmarsson
    Department of Nephrology, Sahlgrenska Acaedmy, Gothenburg, Sweden
    Nephrol Dial Transplant 21:1223-30. 2006
    In a hitherto unconfirmed report, orosomucoid was reported to ameliorate the nephrotic syndrome induced by puromycin aminonucleoside (PAN) in rats.
  25. ncbi Orosomucoid in urine is a powerful predictor of cardiovascular mortality in normoalbuminuric patients with type 2 diabetes at five years of follow-up
    M S Christiansen
    Department of Clinical Biochemistry, Amager Hospital, Italiensvej 1, 2300 Copenhagen, Denmark
    Diabetologia 48:386-93. 2005
    To study whether urinary orosomucoid excretion rate (UOER) predicts mortality in normoalbuminuric patients with diabetes at 5 years of follow-up, and to investigate the relationship between orosomucoid in serum and urine.
  26. ncbi Targeting specificity and pharmacokinetics of asialoorosomucoid, a specific ligand for asialglycoprotein receptor on hepatocyte
    Dong Ye Yang
    The Center for Biotechnology and BioMedicine, Graduate School at Shenzhen, Tsinghua University, Shenzhen, and Department of Gastroenterology, Xiangya Second Hospital, Changsha, Hunan, China
    J Dig Dis 8:89-95. 2007
    ..To testify that the asialoorosomucoid (ASOR) prepared by us has liver-targeting specificity and to investigate its pharmacokinetic characteristics...
  27. ncbi Role of orosomucoid in the regulation of plasma proteolytic systems during experimental renal failure
    M V Osikov
    Department of Pathophysiology, Chelyabinsk State Medical Academy, Federal Agency for Health Care and Social Development, Russia
    Bull Exp Biol Med 148:20-2. 2009
    ..Treatment with glycoprotein was followed by partial recovery of fibrin formation and complement system. These changes were probably related to accumulation of glycoprotein in the renal tissue and in situ protective effect...
  28. ncbi Increased urinary orosomucoid excretion is not related to impaired renal function in patients with type 2 diabetes
    Merete Skovdal Christiansen
    Department of Clinical Biochemistry, Amager Hospital, Copenhagen, Denmark
    J Diabetes Complications 24:28-36. 2010
    Increased urinary orosomucoid excretion rate (UOER) independently predicted cardiovascular mortality in patients with type 2 diabetes at 5-years of follow-up...
  29. ncbi Isoform differentiation of intact AGP from human serum by capillary electrophoresis-mass spectrometry
    Sara Ongay
    Institute of Organic Chemistry C S I C, Juan de la Cierva 3, 28006, Madrid, Spain
    Anal Bioanal Chem 398:845-55. 2010
    ..High inter-individual variability among AGP isoforms expression was observed. The presented method enables for the first time clinical studies based on detailed isoform distribution of intact glycoproteins...
  30. ncbi Stage-dependent increase of orosomucoid and zinc-alpha2-glycoprotein in urinary bladder cancer
    Ster Irmak
    Department of Urology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Proteomics 5:4296-304. 2005
    ..with subsequent MS analyses, conventional immunoblotting and immunohistochemistry we identified two proteins, orosomucoid (ORM) and human zinc-alpha(2)-glycoprotein (ZAG), which were increased in the urine samples of patients with ..
  31. ncbi Addition of purified orosomucoid preserves the glomerular permeability for albumin in isolated perfused rat kidneys
    E Johnsson
    Department of Physiology, , Sweden
    Acta Physiol Scand 147:1-8. 1993
    The serum protein, orosomucoid has been shown to be essential for the maintenance of normal capillary permeability in several different organs, including the kidney...
  32. ncbi Evidence for the existence of multiple alpha 1-acid glycoprotein genes in the mouse
    R Cooper
    J Biol Chem 261:1849-53. 1986
    ..Kaufmann, H., Isemura, S., Bauer, F., Emura, J., Motoyama, T., Ishiguro, M., and Nanno, S. (1973) Biochemistry 12, 2711-2724), we propose that at least two functional AGP genes may also exist in humans...
  33. ncbi The effect of dietary soy genistein on pig growth and viral replication during a viral challenge
    L L Greiner
    Department of Animal Science, Iowa State University, Ames 50011, USA
    J Anim Sci 79:1272-9. 2001
    ..These data indicate that soy genistein at dietary concentrations of 200 to 400 ppm is an orally active immune modulator that enhances systemic serum virus elimination and body growth in virally challenged pigs...
  34. ncbi Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity
    J Boncela
    Center for Microbiology and Virology, Polish Academy of Sciences 93 232 Lodz, Poland
    J Biol Chem 276:35305-11. 2001
    ....
  35. ncbi Orosomucoid (alpha1-acid glycoprotein) plasma concentration and genetic variants: effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation
    Sara Colombo
    Division of Clinical Pharmacology and Toxicology, University Hospital of Lausanne, Institute of Microbiology, Lausanne, Switzerland
    Clin Pharmacol Ther 80:307-18. 2006
    Protease inhibitors are highly bound to orosomucoid (ORM) (alpha1-acid glycoprotein), an acute-phase plasma protein encoded by 2 polymorphic genes, which may modulate their disposition...
  36. ncbi The influence of alpha1-acid glycoprotein (orosomucoid) and its glycoforms on the function of human thyrocytes and CHO cells transfected with the human TSH receptor
    T Zimmermann-Belsing
    Department of Endocrinology P 2131, University Hospital Righospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Mol Cell Endocrinol 188:241-51. 2002
    Local immunological reactions might influence the structure of alpha1-acid glycoprotein (AGP, orosomucoid) leading to a pathological condition in e.g. the thyroid...
  37. ncbi Fucosylation of alpha1-acid glycoprotein (orosomucoid) compared with traditional biochemical markers of inflammation in recent onset rheumatoid arthritis
    Ingvar Ryden
    Department of Clinical Chemistry, Kalmar County Hospital, S 39185 Kalmar, Sweden
    Clin Chim Acta 317:221-9. 2002
    Fucosylation of alpha1-acid glycoprotein (AGP, orosomucoid) has previously been found to be increased in patients with rheumatoid arthritis. Furthermore, the degree of fucosylation has been suggested to reflect disease activity...
  38. ncbi Evaluation of the effect of the immunopurification-based procedures on the CZE-UV and CZE-ESI-TOF-MS determination of isoforms of intact alpha-1-acid glycoprotein from human serum
    Sara Ongay
    Institute of Organic Chemistry C S I C, Madrid, Spain
    Electrophoresis 31:1796-804. 2010
    ..Both CZE methods show no indication that acidic precipitation influences the glycosylation (including sialylation) of AGP...
  39. ncbi Liquid chromatographic and mass spectrometric analysis of human serum acid alpha-1-glycoprotein
    T Kremmer
    National Institute of Oncology, Department of Biochemistry, PO Box 21, H 1122 Budapest, Hungary
    Biomed Chromatogr 18:323-9. 2004
    Human serum acid alpha-1-glycoprotein (AGP, orosomucoid) content of healthy individuals and cancer patients was measured, isolated and purified using a protocol of fast and biocompatible sample preparation, ion exchange and dye-ligand ..
  40. ncbi Molecular cloning and nucleotide sequence of complementary DNA encoding rabbit alpha 1-acid glycoprotein
    B K Ray
    Department of Veterinary Microbiology, University of Missouri, Columbia 65211
    Biochem Biophys Res Commun 178:507-13. 1991
    ..Such a response of AGP gene expression makes it a major member of the acute phase responsive genes in rabbit liver...
  41. ncbi A comparison of the concentrations of C-reactive protein and alpha1-acid glycoprotein in the serum of young and adult dogs with acute inflammation
    S Hayashi
    Laboratory of Immunology, Faculty of Environmental and Health Sciences, Azabu University, Sagamihara, Kanagawa, Japan
    Vet Res Commun 25:117-26. 2001
    ..The CRP and AAG in dogs inoculated with the viral vaccine did not increase. In dogs with fractures or subjected to percutaneous gastrostomy, the CRP and AAG concentrations correlated with the condition of dogs...
  42. ncbi Quantitative evaluation of lectin-reactive glycoforms of α(1)-acid glycoprotein using lectin affinity capillary electrophoresis with fluorescence detection
    Kiyohito Shimura
    Department of Natural Sciences, School of Medicine, Fukushima Medical University, Fukushima, Japan
    Electrophoresis 32:2188-93. 2011
    ....
  43. ncbi Altered glycosylation of alpha1-acid glycoprotein in patients with inflammation and diabetes mellitus
    Koji Higai
    Department of Clinical Chemistry, School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan
    Clin Chim Acta 329:117-25. 2003
    ..In this study, we investigated N-glycan structures of AGP purified from the sera of patients with acute inflammation (n=5), type 2 diabetes mellitus (n=5), and healthy individuals (n=5)...
  44. ncbi Long-term pathologic changes of alpha1-acid glycoprotein (orosomucoid) glycoforms in autoimmune thyroid disease
    T Zimmermann-Belsing
    Department of Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Autoimmunity 35:441-7. 2002
    ..We measured alpha1-acid-glycoprotein (AGP) in patients with autoimmune thyroid disease to study a possible relationship between microheterogeneity of the naturally occurring glycoforms of AGP and autoimmune thyroid disease...
  45. ncbi Severe rheumatoid arthritis prohibits the pregnancy-induced decrease in alpha3-fucosylation of alpha1-acid glycoprotein
    E C Havenaar
    Department of Medical Chemistry, Vrije Universiteit, Amsterdam, The Netherlands
    Glycoconj J 15:723-9. 1998
    ..This indicates a relationship between changes in alpha3-fucosylation of AGP and RA disease activity...
  46. ncbi Rat alpha 1-acid glycoprotein mRNA. Cloning of double-stranded cDNA and kinetics of induction of mRNA levels following acute inflammation
    G A Ricca
    J Biol Chem 256:10362-8. 1981
  47. ncbi The acute phase response of acid soluble glycoprotein, alpha(1)-acid glycoprotein, ceruloplasmin, haptoglobin and C-reactive protein, in the pig
    P D Eckersall
    Department of Veterinary Medicine, University of Glasgow Veterinary School, UK
    Vet Immunol Immunopathol 51:377-85. 1996
    ..C-reactive protein and haptoglobin are likely to be the best markers for the identification of inflammatory lesions in pigs...
  48. pmc Human alpha1-acid glycoprotein binds to CCR5 expressed on the plasma membrane of human primary macrophages
    A Atemezem
    Laboratoire de Biologie Cellulaire, JE 2138, faculté de médecine Leonard de Vinci, Universite Paris XIII, Bobigny 93017, France
    Biochem J 356:121-8. 2001
    ..This suggests that the inhibitory effect of AGP on the infection of human primary macrophages by R5 HIV-1 may be related to specific binding of AGP to a macrophage membrane lectin or lectin-like component and to CCR5...
  49. ncbi Glycosylation of alpha1-acid glycoprotein in inflammatory disease: analysis by high-pH anion-exchange chromatography and concanavalin A crossed affinity immunoelectrophoresis
    I Ryden
    Department of Clinical Chemistry, County Hospital, Kalmar, Sweden
    Glycoconj J 14:481-8. 1997
    ....
  50. ncbi Beneficial effect of albumin therapy attributable to alpha1-acid glycoprotein?
    Eva Maria Muchitsch
    Stroke 34:4-5; author reply 4-5. 2003
  51. ncbi Development of a fast and simple immunochromatographic method to purify alpha 1-acid glycoprotein from serum for analysis of its isoforms by capillary electrophoresis
    Sara Ongay
    Institute of Organic Chemistry C S I C, Juan de la Cierva 3, 28006 Madrid, Spain
    Anal Chim Acta 663:206-12. 2010
    ..The applicability of this fast and easy purification method developed for analyzing by CZE isoforms of AGP from natural serum samples by CZE is demonstrated...
  52. ncbi Receptor-mediated uptake of human alpha1-acid glycoprotein into liver parenchymal cells in mice
    Kazuaki Matsumoto
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862 0973, Japan
    Drug Metab Pharmacokinet 25:101-7. 2010
    ..These findings help improve our understanding of the clearance mechanism of AGP...
  53. ncbi Increased alpha3-fucosylation of alpha(1)-acid glycoprotein in patients with congenital disorder of glycosylation type IA (CDG-Ia)
    W Van Dijk
    Glycoimmunology Group, Department of Molecular Cell Biology, Reaearch Institute Immunology and Inflammatory Disease, VU Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    FEBS Lett 494:232-5. 2001
    ..The concomitantly occurring increased branching of the glycans of AGP and the increased fucosyltransferase activity in plasma suggest that a chronic hepatic inflammatory reaction has induced the increase in fucosylation...
  54. pmc The acute phase reactant orosomucoid-1 is a bimodal regulator of angiogenesis with time- and context-dependent inhibitory and stimulatory properties
    Giovanni Ligresti
    Department of Pathology, University of Washington, Seattle, Washington, USA
    PLoS ONE 7:e41387. 2012
    ..the genes upregulated in wounded tissues are tumor necrosis factor-alpha (TNFα) and the acute phase reactant orosomucoid-1 (ORM1)...
  55. ncbi Activated human PMN synthesize and release a strongly fucosylated glycoform of alpha1-acid glycoprotein, which is transiently deposited in human myocardial infarction
    Dennis C W Poland
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Leukoc Biol 78:453-61. 2005
    ..We suggest that AGP glycoforms in PMN provide an endogenous feedback-inhibitory response to excessive inflammation...
  56. ncbi Pro-angiogenic properties of orosomucoid (ORM)
    Ster Irmak
    Institute of Anatomy, University Hospital Essen, Hufelandstr 55, D 45147 Essen, Germany
    Exp Cell Res 315:3201-9. 2009
    The acute phase protein orosomucoid (ORM), also known as alpha1-acid glycoprotein (AGP), is found to be increased in infection, inflammation and cancer...
  57. ncbi Serum acute phase protein concentrations in dogs with autoimmune hemolytic anemia
    K D Mitchell
    Department of Clinical Studies, University of Guelph, Guelph, ON, Canada
    J Vet Intern Med 23:585-91. 2009
    ..Serial monitoring of acute phase protein (APP) concentrations in canine autoimmune hemolytic anemia (AIHA) has not been reported...
  58. ncbi Function-stabilizing mechanism of plasminogen activator inhibitor type 1 induced upon binding to alpha1-acid glycoprotein
    Katarzyna Smolarczyk
    Center of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Biochemistry 44:12384-90. 2005
    ..In conclusion, our present data suggest that AGP binding stabilizes the active conformation of PAI-1 by restricting the movement of beta-sheet A and thereby preventing insertion of the reactive center loop...
  59. ncbi Inducible expression and regulation of the alpha 1-acid glycoprotein gene by alveolar macrophages: prostaglandin E2 and cyclic AMP act as new positive stimuli
    T Fournier
    Institut National de la Sante et de la Recherche Medicale, Unité 408, Faculte Xavier Bichat, Paris, France
    J Immunol 163:2883-90. 1999
    ..Our data showed that 1) AGP expression is inducible specifically in alveolar macrophages in vivo and in vitro; and 2) PGE2 and cAMP act as new positive stimuli for AGP gene expression...
  60. ncbi Association between faecal shedding of feline coronavirus and serum alpha1-acid glycoprotein sialylation
    Saverio Paltrinieri
    Dipartimento di Patologia Animale Igiene e Sanità Pubblica Veterinaria, Via Celoria 10, Milan, Italy
    J Feline Med Surg 10:514-8. 2008
    ..These results suggest that hypersialylation of AGP may be involved in host-virus interactions...
  61. ncbi The acute-phase protein alpha 1-acid glycoprotein (AGP) induces rises in cytosolic Ca2+ in neutrophil granulocytes via sialic acid binding immunoglobulin-like lectins (siglecs)
    Peter Gunnarsson
    Division of Pharmacology, Department of Medicine and Care, Linkoping University, S 581 85 Linkoping, Sweden
    FASEB J 21:4059-69. 2007
    ..Our report provides the first evidence for a signaling capacity by AGP through a defined receptor. Pre-engagement of L-selectin significantly enhanced this signaling capacity...
  62. ncbi Membrane-induced conformational change of alpha1-acid glycoprotein characterized by vacuum-ultraviolet circular dichroism spectroscopy
    Koichi Matsuo
    Hiroshima Synchrotron Radiation Center, Hiroshima University, Higashi Hiroshima 739 0046, Japan
    Biochemistry 48:9103-11. 2009
    ..These results provide the first sequence-level information on the membrane-binding mechanism and structure-function relationship of AGP...
  63. pmc Adipocytokine orosomucoid integrates inflammatory and metabolic signals to preserve energy homeostasis by resolving immoderate inflammation
    Yun Sok Lee
    Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 285:22174-85. 2010
    b>Orosomucoid (ORM), also called alpha-1 acid glycoprotein, is an abundant plasma protein that is an immunomodulator induced by stressful conditions such as infections...
  64. ncbi alpha1-acid glycoprotein fucosylation as a marker of carcinoma progression and prognosis
    Shinji Hashimoto
    Department of General Surgical Science Surgery 1, Gunma University, Graduate School of Medicine, Maebashi, Japan
    Cancer 101:2825-36. 2004
    ..Serum alpha1-acid glycoprotein (AGP), an acute-phase protein secreted by the liver, carries alpha(1,3)-fucosylated structures on its 5 highly branched, N-linked sugar chains...
  65. ncbi Binding of alpha1-acid glycoprotein to membrane results in a unique structural change and ligand release
    Koji Nishi
    Graduate School of Pharmaceutical Science, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Biochemistry 43:10513-9. 2004
    ..The conformational change induces binding to the membrane aided by electrostatic interaction, and AGP subsequently takes on a predominantly alpha-helical conformation...
  66. ncbi Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis
    Bart de Vries
    Department of Surgery, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Academic Hospital Maastricht and Maastricht University, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands
    Transplantation 78:1116-24. 2004
    ..However, the precise mechanism of protection remains to be established. We therefore studied the effects of exogenous human AGP (hAGP) in a mouse model of ischemic acute renal failure...
  67. ncbi Structural and drug-binding properties of alpha(1)-acid glycoprotein in reverse micelles
    Koji Nishi
    Biopharmaceutics Laboratory, Faculty of Pharmaceutical Science, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
    Biochim Biophys Acta 1601:185-91. 2002
    ..The present results suggest that when AGP interacts with the biomembrane, it undergoes a structural transition to a unique structure that differs from the native and denatured states and has a reduced ligand-binding capacity...
  68. ncbi Determination of alpha-1 acid glycoprotein in patients with Ph+ chronic myeloid leukemia during the first 13 weeks of therapy with STI571
    Philipp Le Coutre
    Abteilung für Hämatologie und Onkologie, Campus Virchow, Charite, Humboldt Universitat, Berlin, Germany
    Blood Cells Mol Dis 28:75-85. 2002
    ....
  69. ncbi Determination of drug-serum protein interactions via fluorescence polarization measurements
    Ulf Mathias
    Institute of Pharmaceutical Sciences, University of Freiburg, Albertstr 25, Freiburg, Germany
    Anal Bioanal Chem 388:1147-56. 2007
    ..Figure Fluorescence polarization displacement titration of dansylsarcosine (3D-structure as insert) bound to human serum albumin (HSA) by naproxene...
  70. ncbi Structure of human alpha1-acid glycoprotein and its high-affinity binding site
    Vladimír Kopecký
    Institute of Physics, Charles University, Ke Karlovu 5, CZ 12116 Prague 2, Czech Republic
    Biochem Biophys Res Commun 300:41-6. 2003
    ..Raman difference spectroscopy confirmed the proximity of Trp(122) to progesterone binding...
  71. ncbi Kinetics of {alpha}2-macroglobulin and {alpha}1-acid glycoprotein in rats subjected to repeated acute inflammatory stimulation
    Toshio Honjo
    Azabu University, Fuchinobe, Sagamihara, Kanagawa, Japan
    Lab Anim 44:150-4. 2010
    ..05 and 0.4 mL/rat injection groups. Differences in peak serum levels in the 0.05 and 0.4 mL/rat groups were attributed to differences in the production of IL-6 and CINC-1, which are thought to contribute to alpha2M and AAG production...
  72. ncbi Macrophage inhibitory factor, plasminogen activator inhibitor-1, other acute phase proteins, and inflammatory mediators normalize as a result of weight loss in morbidly obese subjects treated with gastric restrictive surgery
    F M H van Dielen
    Department of General Surgery, Nutrition Research Institute Maastricht and University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 89:4062-8. 2004
    ..However, 2 yr after surgery, the inflammatory mediators reach near normal values.These findings may be an explanation for the reduced comorbidity seen in morbidly obese patients after gastric restrictive surgery...
  73. ncbi Organogold complexes probe a large beta-barrel cavity for human serum alpha1-acid glycoprotein
    Ferenc Zsila
    Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, P O Box 17, H 1525, Hungary
    Biochim Biophys Acta 1784:1106-14. 2008
    ..The organogold complexes were successfully docked into the central cavity of this model...
  74. ncbi Preventive and therapeutic effects of alpha-acid glycoprotein in mice infected with B. anthracis
    I G Shemyakin
    State Research Center of Applied Microbiology, Obolensk, Moscow
    Bull Exp Biol Med 140:439-44. 2005
    ..Administration of the test preparations 24 h after infection decreased the concentration of tumor necrosis factor-alpha...
  75. ncbi Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S
    I Yuasa
    Department of Legal Medicine, Tottori University School of Medicine, Yonago, Japan
    Hum Genet 99:393-8. 1997
    The human orosomucoid (ORM) is controlled by two closely linked loci, ORM1 and ORM2, and two tandem genes, AGP1 and AGP2, encoding the proteins produced by the two loci, have been cloned...
  76. ncbi The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin
    Dorian L Schönfeld
    Lehrstuhl fur Biologische Chemie, Technische Universitat Munchen, An der Saatzucht 5, 85350 Freising Weihenstephan, Germany
    J Mol Biol 384:393-405. 2008
    ....
  77. ncbi Different temperature sensitivity of endosomes involved in transport to lysosomes and transcytosis in rat hepatocytes: analysis by free-flow electrophoresis
    Isabella Ellinger
    Department of Pathophysiology, University of Vienna, Vienna, Austria
    Electrophoresis 23:2117-29. 2002
    ....
  78. ncbi H2, the minor subunit of the human asialoglycoprotein receptor, trafficks intracellularly and forms homo-oligomers, but does not bind asialo-orosomucoid
    Amit Saxena
    Department of Biochemistry and Molecular Biology, and The Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    J Biol Chem 277:35297-304. 2002
    ..However, unlike H1, which can bind the ligand asialo-orosomucoid (ASOR) when overexpressed in COS-7 cells, H2 failed to bind or endocytose ASOR...
  79. pmc Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein
    M J Treuheit
    Department of Chemistry, University of Cincinnati, OH 45221 0172
    Biochem J 283:105-12. 1992
    b>Orosomucoid (OMD) contains complex bi-, tri- and tetra-antennary glycan chains. Subfractionation of OMD into three molecular variants using concanavalin A lectin chromatography is based on variations in these complex structures...
  80. ncbi Pathophysiological and immune cell responses in calves prior to and following lung challenge with formalin-killed Pasteurella multocida biotype A:3 and protection studies involving subsequent homologous live challenge
    A Dowling
    Bacteriology Division, Moredun Research Institute, International Research Centre, Pentlands Science Park, Penicuik, Midlothian EH26 0PZ, UK
    Vet Immunol Immunopathol 100:197-207. 2004
    ..multocida was able to survive intracellularly during this assay. There was no indication that lung exposure to formalin-killed P. multocida conferred protection against subsequent homologous live challenge...
  81. ncbi Pre-symptomatic increase in urine-orosomucoid excretion in pre-eclamptic women
    Camilla S Kronborg
    Department of Gynecology and Obstetrics, Randers County Hospital, Randers, Denmark
    Acta Obstet Gynecol Scand 86:930-7. 2007
    ..We evaluated urine excretion and plasma levels of orosomucoid and albumin longitudinally in healthy and pre-eclamptic pregnancies...
  82. ncbi Factors affecting cytochrome P-450 3A activity in cancer patients
    Sharyn D Baker
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231 1000, USA
    Clin Cancer Res 10:8341-50. 2004
    ..The purpose is to identify the demographic, physiologic, and inheritable factors that influence CYP3A activity in cancer patients...
  83. ncbi Alpha-1-acid glycoprotein as an independent predictor for treatment effects and a prognostic factor of survival in patients with non-small cell lung cancer treated with docetaxel
    Rene Bruno
    Drug Metabolism and Pharmacokinetics, Aventis Pharma SA, tri E2 325, 20 Avenue Raymond Aron, 92165 Antony Cedex, France
    Clin Cancer Res 9:1077-82. 2003
    ..To identify predictors of treatment outcome and survival in patients with non-small cell lung cancer (NSCLC) treated with docetaxel...
  84. ncbi Identification of alpha 1-acid glycoprotein (orosomucoid) in human synovial fluid by capillary electrophoresis
    A Rice
    School of Biology and Biochemistry, Queen's University of Belfast, UK
    J Chromatogr A 772:305-11. 1997
    ..The hydrophilic glycoprotein is identified as alpha 1-acid glycoprotein (AGP), orosomucoid, by co-injection methods with human AGP and by reaction with neuraminidase which released N-acetylneuraminic ..
  85. ncbi Monitoring urinary orosomucoid in acute inflammation: observations on urinary excretion of orosomucoid, albumin, alpha1-microglobulin, and IgG
    Erik Magid
    Departments of Clinical Biochemistry and Anaesthesiology, Amager Hospital, Copenhagen, Denmark
    Clin Chem 51:2052-8. 2005
    ..We performed an observational study of the urinary excretion of orosomucoid (alpha(1)-acid glycoprotein), albumin, alpha(1)-microglobulin (protein HC), and IgG to obtain quantitative and ..
  86. ncbi The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2
    H Nakamura
    Department of Legal Medicine, Shimane Medical University, Izumo, 693 8501, Japan
    Biochem Biophys Res Commun 276:779-84. 2000
    The human alpha(1)-acid glycoprotein (AGP) or orosomucoid (ORM) is controlled by the two tandemly arranged genes, AGP1 and AGP2...
  87. ncbi Long-term change in cholesterol in relation to inflammation-sensitive plasma proteins: a longitudinal study
    Gunnar Engstrom
    Department of Clinical Science, Section for Epidemiology, Lund University, Malmo University Hospital, Sweden
    Ann Epidemiol 17:57-63. 2007
    ..This longitudinal study explores whether elevated levels of inflammation-sensitive plasma proteins (ISPs) are a risk factor for developing increased cholesterol and triglyceride levels...
  88. ncbi Risk of myocardial infarction and stroke in smokers is related to plasma levels of inflammation-sensitive proteins
    P Lind
    Department of Internal Medicine, Malmo University Hospital, S 20502 Malmo, Sweden
    Arterioscler Thromb Vasc Biol 24:577-82. 2004
    ....
  89. ncbi Reference maps of mouse serum acute-phase proteins: changes with LPS-induced inflammation and apolipoprotein A-I and A-II transgenes
    Robin Wait
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, UK
    Proteomics 5:4245-53. 2005
    ..The greatest changes (four-fold 48 h after LPS administration) were observed for haptoglobin and hemopexin. Orosomucoid/alpha(1)-acid glycoprotein and apolipoprotein A-I increased steadily, to 50-60% above baseline at 96 h from ..
  90. ncbi N-acetylcysteine for preventing pump-induced oxidoinflammatory response during cardiopulmonary bypass
    Nehir Sucu
    Department of Cardiovascular Surgery, Mersin University, Medical School, Zeytinlibahce Cad, 33079 Mersin, Turkey
    Surg Today 34:237-42. 2004
    ..To investigate the effect of N-acetylcysteine on preventing pump-induced oxidoinflammatory response during cardiopulmonary bypass (CPB)...
  91. ncbi Interpretation of serum ferritin concentrations as indicators of total-body iron stores in survey populations: the role of biomarkers for the acute phase response
    John L Beard
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Am J Clin Nutr 84:1498-505. 2006
    ..Few, however, have examined which biomarker better identifies persons with spurious elevations in iron status markers...
  92. ncbi Inflammation and reduced albumin synthesis associated with stable decline in serum albumin in hemodialysis patients
    George A Kaysen
    Division of Nephrology, Department of Medicine, University of California Davis, Davis, California 95616, USA
    Kidney Int 65:1408-15. 2004
    ..3 g/dL was accompanied by a change in albumin synthesis and if so whether these changes were associated with increased levels of acute phase proteins and/or with a decrease in equilibrated normalized protein catabolic rate (enPCR)...
  93. ncbi [Drug binding to blood proteins: characteristics, roles and pathophysiological changes]
    Jean Paul Tillement
    Unité Fonctionnelle de Pharmacologie et Toxicologie, CHIC, 40 avenue de Verdun, F 94010 Creteil
    Bull Acad Natl Med 190:935-46; discussion 946-7. 2006
    ..Low binding capacities are said to be permissive, as they do not lead to drug retention. Modifications of restrictive binding can influence other pharmacokinetic parameters and also have clinical implications...
  94. ncbi Inflammation-sensitive plasma proteins and incidence of myocardial infarction in men with low cardiovascular risk
    Gunnar Engstrom
    Department of Community Medicine, Malmo University Hospital, S 20502 Malmo, Sweden
    Arterioscler Thromb Vasc Biol 23:2247-51. 2003
    ..This prospective study explored whether incidence of MI in nonsmoking, nondiabetic men with normal blood pressure and serum lipids is related to inflammation-sensitive plasma proteins (ISPs)...
  95. ncbi [Does the estimation of acute phase protein concentrations in cerebrospinal fluid and/or in serum in patients with viral meningitis carry diagnostic importance? Part I. Lymphocytic meningitis caused by epidemic parotitis]
    Marek Łobos
    Katedra Diagnostyki Laboratoryjnej, Zakład Diagnostyki Laboratoryjnej i Biochemii Klinicznej Uniwersytet Medyczny w Łodzi
    Przegl Epidemiol 56:615-22. 2002
    ....
  96. ncbi Morphine in children with cancer: impact of age, chemotherapy and other factors on protein binding
    Simin O Mashayekhi
    Department of Therapeutics, Faculty of Pharmacy, Tabriz Medical Science University, Iran
    J Pain Palliat Care Pharmacother 21:5-12. 2007
    ..Binding was unaffected by pH in samples from patients. Morphine binding was influenced by concentrations of albumin, AAG and morphine itself, but not by age...
  97. ncbi Inflammation-sensitive plasma proteins are associated with future weight gain
    Gunnar Engstrom
    Department of Community Medicine, Lund University, Malmo, Sweden
    Diabetes 52:2097-101. 2003
    ..This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) (fibrinogen, orosomucoid, alpha1-antitrypsin, haptoglobin, and ceruloplasmin) are associated with future weight gain...
  98. ncbi Association of classical and related inflammatory markers with high-sensitivity C-reactive protein in healthy individuals: results from the Stanislas cohort
    Hind Berrahmoune
    INSERM, U525, Equipe 4, Nancy, France
    Clin Chem Lab Med 45:1339-46. 2007
    ..Therefore, as a first step, we examined interrelationships between serum hs-CRP concentrations and inflammatory, adhesion and growth factors in healthy adults...
  99. ncbi Elevated inflammation markers in pheochromocytoma compared to other forms of hypertension
    Tomas Zelinka
    3rd Department of Medicine, General Faculty Hospital, Praha, Czech Republic
    Neuroimmunomodulation 14:57-64. 2007
    ..To investigate the effect of long-term catecholamine excess in pheochromocytoma on leukocyte and platelet count and on proteins of acute-phase response...
  100. ncbi The binding of HIV-1 protease inhibitors to human serum proteins
    Arne SchOn
    Department of Biology and Biocalorimetry Center, The Johns Hopkins University, Baltimore, MD 21218, USA
    Biophys Chem 105:221-30. 2003
    ..In these cases the required inhibitor concentrations can be up to 2000 times higher and beyond the solubility limits of the inhibitors...
  101. ncbi Relationship between serum levels of some acute-phase proteins and stage of disease and performance status in patients with lung cancer
    Abdulkadir Yildirim
    Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey
    Med Sci Monit 13:CR195-200. 2007
    ....

Research Grants26

  1. Mechanism of sgk action in the collecting duct
    Geza Fejes Toth; Fiscal Year: 2005
    ..abstract_text> ..
  2. Eosinophil ORMDL3 and allergic inflammation
    P Sriramarao; Fiscal Year: 2012
    ..Studies involving genome-wide association and microarray approaches have led to the identification of orosomucoid 1-like 3 (ORMDL3) as a candidate gene for susceptibility to asthma...
  3. CHADSS: Chagas Disease Scan Study
    Jamary Oliveira-Filho; Fiscal Year: 2013
    ..Biomarkers orosomucoid, neprilysin, interleukin-6 (IL-6) and matrix metalloproteinase-9 (MMP-9) were identified as diagnostic and ..
  4. LOCATION OF PORE SYSTEMS IN CAPILLARY WALLS
    George Palade; Fiscal Year: 2000
    ..I. In the first specific aim, experiments utilizing alpha1-acidic glycoprotein (orosomucoid) as a tracer are proposed to reinforce the concept/process of transcytosis in the handling of macromolecules in ..
  5. LUNG CAPILLARY PERMEABILITY WITH HIGH VASCULAR PRESSURES
    Mary Townsley; Fiscal Year: 1991
    ..of alveolar fluid and protein and to assess the role of endothelial surface charge, the glycoprotein orosomucoid (a modulator of neutrophil radical production), and interstitial hydration in altering permeability, as all are ..
  6. Pharmacogenetics of Methadone
    C Devane; Fiscal Year: 2003
    ..This study will form the basis for subsequent studies which should provide a more rational basis for dosing of methadone in pregnant addicts. ..
  7. GENETIC LINKAGE STUDY OF ALCOHOLISM
    Raymond Crowe; Fiscal Year: 1993
    ..those showing provisional evidence of linkage to alcoholism or depression spectrum disease(esterase D and orosomucoid, respectively), and' p those that can be consider-ed candidate gene loci (alcohol and aldehyde dehydrogenases)...
  8. DIABETES AND CARDIOVASCULAR RISK IN MEXICO CITY
    Michael Stern; Fiscal Year: 2000
    ..e., the hypothesis that both type II diabetes and atherosclerosis have common genetic and environmental antecedents. ..
  9. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..
  10. PHEROMONES--IDENTIFICATION/BIOCHEMICAL STUDIES
    Milos Novotny; Fiscal Year: 2001
    ..Understanding the aspects of chemical communication in the species could also be important in a population control of wild rodents. ..
  11. Structure-Function Analysis of Lactoferrin
    DOUGLAS MCABEE; Fiscal Year: 2002
    ..Lt sub-domains, which when removed from Lf-Tf hybrids elicit a loss-of-binding phenotype, will be placed into a Tf background to determine if they confer a gain-of-binding phenotype on Tf. ..
  12. Antenatal and preschool iron and zinc use and cognition
    Parul Christian; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  13. Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older Women
    Richard Semba; Fiscal Year: 2008
    ..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
  14. Hepcidin and the pathogenesis of anemia in older adults.
    Richard D Semba; Fiscal Year: 2010
    ..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
  15. TRIPTORELIN FOR OVARY PROTECTION IN CHILDHOOD LIPUS
    Hermine Brunner; Fiscal Year: 2007
    ..Abstract Not Provided ..
  16. INTEGRATE/PHARMACOKINETIC/ANTIRETROVIRUS RESISTANCE TEST
    Edward Acosta; Fiscal Year: 2006
    ..abstract_text> ..
  17. Iron Deficiency and Anemia in HIV and HCV-Infected Women
    Richard Semba; Fiscal Year: 2005
    ..S. and elsewhere. ..
  18. ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDS
    Richard Semba; Fiscal Year: 2005
    ....
  19. VITAMIN A SUPPLEMENTATION FOR HIV INFECTED CHILDREN
    Richard Semba; Fiscal Year: 2002
    ....
  20. MICRONUTRIENTS AND MOTHER TO CHILD TRANSMISSION OF HIV
    Richard Semba; Fiscal Year: 2001
    ..The relationship between mastitis and breastmilk HIV load and the epidemiology and microbiology of mastitis will be examined in a new cohort of HIV-infected lactating women. ..
  21. HMGB1/2 and Cellular Response to Fraudulent Nucleosides
    Evgeny Krynetskiy; Fiscal Year: 2007
    ..abstract_text> ..
  22. MOLECULAR MECHANISM OF MINERALOCORTICOID RECEPTOR ACTION
    Geza Fejes Toth; Fiscal Year: 2003
    ..abstract_text> ..
  23. IRON DEFICIENCY AND DOPAMINE
    John Beard; Fiscal Year: 2004
    ..This expansion of study to other neurotransmitters will significantly contribute to our knowledge of the effects of iron deficiency on brain functioning in early life. ..