blood proteins

Summary

Summary: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.

Top Publications

  1. ncbi The human plasma proteome: history, character, and diagnostic prospects
    N Leigh Anderson
    Plasma Proteome Institute, Washington, DC 20009 3450, USA
    Mol Cell Proteomics 1:845-67. 2002
  2. pmc Binding of blood proteins to carbon nanotubes reduces cytotoxicity
    Cuicui Ge
    Chinese Academy of Sciences Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100190, China
    Proc Natl Acad Sci U S A 108:16968-73. 2011
  3. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
  4. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
  5. pmc Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma
    Terri A Addona
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Biotechnol 27:633-41. 2009
  6. ncbi Expression of programmed death 1 ligands by murine T cells and APC
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 169:5538-45. 2002
  7. ncbi Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study
    Markus Ketteler
    Department of Nephrology and Immunology, University Hospital Aachen, Aachen, Germany
    Lancet 361:827-33. 2003
  8. pmc Plasma fetuin-A levels and the risk of type 2 diabetes
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 57:2762-7. 2008
  9. pmc Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons
    Liudmila Lapatsina
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin Buch, Germany
    Open Biol 2:120096. 2012
  10. ncbi The human plasma proteome: a nonredundant list developed by combination of four separate sources
    N Leigh Anderson
    The Plasma Proteome Institute, Washington DC 20009 3450, USA
    Mol Cell Proteomics 3:311-26. 2004

Research Grants

  1. Development of SPR/MS protein array platform
    Dobrin Nedelkov; Fiscal Year: 2007
  2. Development of SPR/MS protein array platform
    Dobrin Nedelkov; Fiscal Year: 2005
  3. Affinity-based Mass Spectrometry Protein Assays
    Dobrin Nedelkov; Fiscal Year: 2004
  4. CHROMATOGRAPHIC STUDIES OF FUNCTIONAL PROTEOMICS
    DAVID HAGE; Fiscal Year: 2009
  5. Proteomic Analysis of Retinal Ganglion Cell Death in Glaucoma
    GULGUN TEZEL; Fiscal Year: 2010
  6. Homocysteine: Vascular Biochemistry and Metabolism
    DONALD JACOBSEN; Fiscal Year: 2005
  7. PE BIOSYSTEMS VOYAGER DE MALDI-TOF
    Kenneth Mann; Fiscal Year: 2001
  8. Vascular Biochemistry of Vitamin B12
    DONALD JACOBSEN; Fiscal Year: 2006
  9. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
  10. Gene Therapy for Neurological Diseases
    Pedro Lowenstein; Fiscal Year: 2006

Detail Information

Publications312 found, 100 shown here

  1. ncbi The human plasma proteome: history, character, and diagnostic prospects
    N Leigh Anderson
    Plasma Proteome Institute, Washington, DC 20009 3450, USA
    Mol Cell Proteomics 1:845-67. 2002
    ....
  2. pmc Binding of blood proteins to carbon nanotubes reduces cytotoxicity
    Cuicui Ge
    Chinese Academy of Sciences Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100190, China
    Proc Natl Acad Sci U S A 108:16968-73. 2011
    ..leukemia cell line and human umbilical vein endothelial cells, reveal that the competitive bindings of blood proteins on the SWCNT surface can greatly alter their cellular interaction pathways and result in much reduced ..
  3. ncbi Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    Haidong Dong
    Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA
    Nat Med 8:793-800. 2002
    ..These findings have implications for the design of T cell-based cancer immunotherapy...
  4. ncbi PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    Y Latchman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Nat Immunol 2:261-8. 2001
    ..Taken together, these studies show overlapping functions of PD-L1 and PD-L2 and indicate a key role for the PD-L-PD-1 pathway in regulatingT cell responses...
  5. pmc Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma
    Terri A Addona
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Nat Biotechnol 27:633-41. 2009
    ..We provide data and benchmarks against which individual laboratories can compare their performance and evaluate new technologies for biomarker verification in plasma...
  6. ncbi Expression of programmed death 1 ligands by murine T cells and APC
    Tomohide Yamazaki
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    J Immunol 169:5538-45. 2002
    ..The inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms of PD-1-mediated immune regulation...
  7. ncbi Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study
    Markus Ketteler
    Department of Nephrology and Immunology, University Hospital Aachen, Aachen, Germany
    Lancet 361:827-33. 2003
    ..We aimed to investigate the hypothesis that AHSG deficiency is directly related to uraemic vascular calcification...
  8. pmc Plasma fetuin-A levels and the risk of type 2 diabetes
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Disease and Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Diabetes 57:2762-7. 2008
    ..We investigated whether plasma fetuin-A levels predict the incidence of type 2 diabetes in a large prospective, population-based study...
  9. pmc Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons
    Liudmila Lapatsina
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin Buch, Germany
    Open Biol 2:120096. 2012
    ..We suggest that the molecular features of this vesicular pool may be characteristic of a 'transducosome' in sensory neurons...
  10. ncbi The human plasma proteome: a nonredundant list developed by combination of four separate sources
    N Leigh Anderson
    The Plasma Proteome Institute, Washington DC 20009 3450, USA
    Mol Cell Proteomics 3:311-26. 2004
    ..The resulting nonredundant list confirms the presence of a number of interesting candidate marker proteins in plasma and serum...
  11. ncbi HUPO Plasma Proteome Project specimen collection and handling: towards the standardization of parameters for plasma proteome samples
    Alex J Rai
    The Johns Hopkins University School of Medicine, Department of Pathology, Division of Clinical Chemistry, Baltimore, MD 21287 7065, USA
    Proteomics 5:3262-77. 2005
    ..These findings help provide guidance on sample handling issues, with the overall suggestion being to be conscious of all possible pre-analytical variables as a prerequisite of any proteomic study...
  12. ncbi Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans
    Norbert Stefan
    Department of Internal Medicine, University of Tubingen, Germany
    Diabetes Care 29:853-7. 2006
    ..Therefore, we hypothesized that the AHSG plasma protein, which is exclusively secreted by the liver in humans, may not only be associated with insulin resistance but also with fat accumulation in the liver...
  13. pmc Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study
    Joachim H Ix
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
    Circulation 113:1760-7. 2006
    ..We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease...
  14. pmc Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    Yoshiko Iwai
    Department of Medical Chemistry, Graduate School of Medicine, Japan Science and Technology Corporation, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 99:12293-7. 2002
    ....
  15. ncbi An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)
    Lars G Fritsche
    Institute of Human Genetics, University of Regensburg, Franz Josef Strauss Allee 11, Regensburg, Germany
    Hum Mol Genet 19:4694-704. 2010
    ..Our findings allude to a critical balance between the complement regulators CFHR3, CFHR1 and factor H and further emphasize the central role of complement regulation in AMD pathology...
  16. pmc The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification
    Cora Schafer
    Interdisciplinary Center for Clinical Research on Biochematerials, University Clinics, Aachen, Germany
    J Clin Invest 112:357-66. 2003
    ..Taken together, our data demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide a novel therapeutic concept to prevent ectopic calcification accompanying various diseases...
  17. ncbi Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins
    S Tsukita
    College of Medical Technology, Kyoto University, Sakyo ku, Kyoto 606, Japan
    J Biol Chem 274:34507-10. 1999
  18. ncbi High-abundance polypeptides of the human plasma proteome comprising the top 4 logs of polypeptide abundance
    Glen L Hortin
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Clin Chem 54:1608-16. 2008
    ..Plasma contains thousands of proteins, but a small number of these proteins comprise the majority of protein molecules and mass...
  19. ncbi Serum peptide profiling by magnetic particle-assisted, automated sample processing and MALDI-TOF mass spectrometry
    Josep Villanueva
    Protein Center, Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Anal Chem 76:1560-70. 2004
    ..This, in turn, served to create a learning algorithm that correctly predicted 96.4% of the samples as either normal or diseased...
  20. ncbi Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database
    Gilbert S Omenn
    Internal Medicine, University of Michigan, Ann Arbor, MI 48109 0656, USA
    Proteomics 5:3226-45. 2005
    ....
  21. pmc Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome
    Peter F Zipfel
    Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena, Germany
    PLoS Genet 3:e41. 2007
    ..The identification of CFHR1/CFHR3 deficiency in aHUS patients may lead to the design of new diagnostic approaches, such as enhanced testing for these genes...
  22. pmc Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group
    Melissa K Tuck
    Division of Hematology Oncology, University of Michigan, Ann Arbor, Michigan 48109 0725, USA
    J Proteome Res 8:113-7. 2009
    ..This report presents our consensus on SOPs for the collection, processing, handling, and storage of serum and plasma for biomarker discovery and validation...
  23. pmc Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
    D Reczek
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 139:169-79. 1997
    ..Since PDZ domains are known to mediate associations with integral membrane proteins, one mode of membrane attachment of ezrin is likely to be mediated through EBP50...
  24. pmc Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs
    Hannah M Burgess
    MRC Centre for Reproductive Health MRC Human Reproductive Sciences Unit, Queens Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Cell Sci 124:3344-55. 2011
    ..These data also provide mechanistic insight into reports that transcriptional inhibitors and expression of certain viral proteins cause relocation of PABP to the nucleus...
  25. ncbi Comparative study of three proteomic quantitative methods, DIGE, cICAT, and iTRAQ, using 2D gel- or LC-MALDI TOF/TOF
    Wells W Wu
    Proteomics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Proteome Res 5:651-8. 2006
    ..Protein profiling on HCT-116 and HCT-116 p53 -/- cell lysates displayed limited overlapping among proteins identified by the three methods, suggesting the complementary nature of these methods...
  26. ncbi Depletion of one, six, twelve or twenty major blood proteins before proteomic analysis: the more the better?
    Stephane Roche
    CHU Montpellier, Biochimie Saint Eloi, Plateforme de Protéomique Clinique 80 av A Fliche, Montpellier, France
    J Proteomics 72:945-51. 2009
    Depletion of major blood proteins is one of the most promising approaches to access low abundant biomarkers using proteomics...
  27. ncbi Structural basis of calcification inhibition by alpha 2-HS glycoprotein/fetuin-A. Formation of colloidal calciprotein particles
    Alexander Heiss
    IZKF BIOMAT, University Clinics, RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Biol Chem 278:13333-41. 2003
    ..The computer-modeled domain structures suggest that a dense array of acidic residues on an extended beta-sheet of the cystatin-like domain Ahsg-D1 mediates efficient inhibition...
  28. ncbi Stomatin modulates gating of acid-sensing ion channels
    Margaret P Price
    Department of Internal Medicine, University of Iowa College of Medicine, 200 Hawkins Dr, Iowa City, IA 52242, USA
    J Biol Chem 279:53886-91. 2004
    ..Our findings indicate that modulation of DEG/ENaC channels by stomatin-like proteins is evolutionarily conserved and may have important implications for mammalian nociception and mechanosensation...
  29. ncbi MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
    Miriam B Goodman
    Department of Biological Sciences, Columbia University, New York 10027, USA
    Nature 415:1039-42. 2002
    ..Some of these channels may mediate mechanosensory responses...
  30. ncbi Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification
    Joanne L Reynolds
    Division of Cardiovascular Medicine, Level 6, ACCI, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Am Soc Nephrol 16:2920-30. 2005
    ..Strategies aimed at maintaining normal circulating levels of fetuin-A may prove beneficial in patients with ESRD...
  31. pmc Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome
    Iain Moore
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    Blood 115:379-87. 2010
    ..In 5 patients mutations were identified: 1 in CFH, 1 in CFI, 1 in CD46, and 2 in C3. The latter observation emphasizes that multiple concurrent factors may be necessary in individual patients for disease manifestation...
  32. ncbi Protein biomarker discovery and validation: the long and uncertain path to clinical utility
    Nader Rifai
    Departments of Laboratory Medicine and Pathology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Nat Biotechnol 24:971-83. 2006
    ....
  33. ncbi Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency
    Mihaly Jozsi
    Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
    Blood 111:1512-4. 2008
    ..Screening for both factors is obviously relevant for HUS patients as reduction of CFH autoantibody levels represents a therapeutic option...
  34. ncbi ERM proteins in cell adhesion and membrane dynamics
    P Mangeat
    Universite Montpellier II, CNRS UMR 5539, C C 107, 34095 Montpellier Cedex 05, France
    Trends Cell Biol 9:187-92. 1999
    ..This review discusses current understanding of the structure and function of members of the ERM family of proteins...
  35. ncbi Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Str 5, D 45711 Datteln, Germany
    J Clin Endocrinol Metab 93:4479-85. 2008
    ..There are very limited data available concerning the relationships between fetuin-A, weight status, nonalcoholic fatty liver disease (NAFLD), and features of the metabolic syndrome (MetS) in obese humans, and especially in children...
  36. ncbi Peptidomic analysis of human blood specimens: comparison between plasma specimens and serum by differential peptide display
    Harald Tammen
    BioVisioN AG, Hannover, Germany
    Proteomics 5:3414-22. 2005
    ..For analysis of the low-molecular-weight proteome, we recommend the use of platelet-depleted EDTA or citrate plasma...
  37. ncbi PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2
    LauraL Carter
    Wyeth Genetics Institute, Cambridge, MA 02140, USA
    Eur J Immunol 32:634-43. 2002
    ..However, CD8(+) T cells may be more sensitive to modulation by the PD-1:PD-L pathway because of their intrinsic inability to produce significant levels of IL-2...
  38. ncbi Serum and plasma proteomics
    Haleem J Issaq
    Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC Frederick, Inc, NCI Frederick, P O Box B, Frederick, Maryland 21702, USA
    Chem Rev 107:3601-20. 2007
  39. ncbi Proteome-based plasma biomarkers for Alzheimer's disease
    A Hye
    King s College London, MRC Centre for Neurodegeneration Research London, UK
    Brain 129:3042-50. 2006
    ..These findings suggest that blood may be a rich source for biomarkers of Alzheimer's disease and that CFH, together with other proteins such as alpha-2M may be a specific markers of this illness...
  40. ncbi Low fetuin-A levels are associated with cardiovascular death: Impact of variations in the gene encoding fetuin
    Peter Stenvinkel
    Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska University Hospital, Stockholm, Sweden
    Kidney Int 67:2383-92. 2005
    ..In the present study, we evaluated the association between fetuin-A, clinical phenotype, and outcome, as well as the impact of fetuin gene (AHSG) polymorphisms on the protein product and outcome...
  41. ncbi The influence of protein adsorption on nanoparticle association with cultured endothelial cells
    Morton S Ehrenberg
    Department of Biomedical Engineering, University of Rochester, Goergen Hall, Rochester, NY 14627, USA
    Biomaterials 30:603-10. 2009
    ..We therefore conclude that cellular association is not dependent on the identity of adsorbed proteins and therefore unlikely to require specific binding to any particular cellular receptors...
  42. pmc Comparison of multiplex immunoassay platforms
    Qin Fu
    Departments of Medicine, Biomedical Engineering, Biological Chemistry, Bayview Proteomics Center, Johns Hopkins University, Baltimore, MD 21224, USA
    Clin Chem 56:314-8. 2010
    ..We have measured the reproducibility, reliability, robustness, accuracy, and throughput of commercially available multiplex immunoassays to ascertain their suitability for serum biomarker analysis and validation...
  43. pmc Enhanced detection of low abundance human plasma proteins using a tandem IgY12-SuperMix immunoaffinity separation strategy
    Wei Jun Qian
    Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Mol Cell Proteomics 7:1963-73. 2008
    ....
  44. ncbi Mass spectrometric quantitation of peptides and proteins using Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA)
    N Leigh Anderson
    Plasma Proteome Institute, PO Box 53450, Washington, DC 20009 3450, USA
    J Proteome Res 3:235-44. 2004
    ..The method appears suitable for rapid generation of assays for defined proteins, and should find application in the validation of diagnostic protein panels in large sample sets...
  45. pmc Proteomic signatures in plasma during early acute renal allograft rejection
    Gabriela V Cohen Freue
    Prevention of Organ Failure PROOF Centre of Excellence, Vancouver, British Columbia, Canada
    Mol Cell Proteomics 9:1954-67. 2010
    ..This study provides evidence that protein concentrations in plasma may provide a relevant measure for the occurrence of BCAR and offers a potential tool for immunologic monitoring...
  46. ncbi Differences among techniques for high-abundant protein depletion
    Nina Zolotarjova
    Agilent Technologies, Wilmington, DE 19808, USA
    Proteomics 5:3304-13. 2005
    ..Significant differences are noted between the depletion techniques employed, and this should be considered based on the expectations set during experimental design...
  47. ncbi Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy
    Stefano Tiziani
    Henry Wellcome Building for Biomolecular NMR Spectroscopy, CR UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TT, UK
    Anal Biochem 377:16-23. 2008
    ..We also describe a new method to recover the hydrophobic fraction for ultrafiltration with good reproducibility...
  48. ncbi Analysis of differentially expressed proteins involved in hand, foot and mouth disease and normal sera
    L Deng
    Guangzhou Women and Children s Medical Center, Guangzhou, China
    Clin Microbiol Infect 18:E188-96. 2012
    ..These findings build up a comprehensive profile of the HFMD proteome and provide a useful basis for further analysis of the pathogenic mechanism and the regulatory network of HFMD...
  49. ncbi Human RhAG ammonia channel is impaired by the Phe65Ser mutation in overhydrated stomatocytic red cells
    Sandrine Genetet
    INSERM U, Paris, France
    Am J Physiol Cell Physiol 302:C419-28. 2012
    ....
  50. ncbi Erysipelas caused by group A streptococcus activates the contact system and induces the release of heparin-binding protein
    Adam Linder
    Division of Infection Medicine, Department of Clinical Sciences, Lund University Hospital, Lund, Sweden
    J Invest Dermatol 130:1365-72. 2010
    ..The results suggest that group A streptococci induce contact activation and HBP release during skin infection, which likely contribute to the symptoms seen in erysipelas: fever, pain, erythema, and edema...
  51. ncbi HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases
    Y Suzuki
    Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 158:2736-44. 1997
    ..Deletion mutant analysis of these proteins reveals that the association is mediated by the amino terminal region of HS1 and the carboxyl-terminal half of HAX-1. The potential role of the HAX-1/HS1 complex is discussed...
  52. ncbi Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry
    Hui Zhang
    Institute for Systems Biology, 1441 N 34th Street, Seattle, Washington 98103 8904, USA
    Nat Biotechnol 21:660-6. 2003
    ..The recovered peptides are then identified and quantified by MS/MS. We applied the approach to the analysis of plasma membrane proteins and proteins contained in human blood serum...
  53. ncbi The relationship between early concentrations of 25 blood proteins and cerebral white matter injury in preterm newborns: the ELGAN study
    Alan Leviton
    Neuroepidemiology Unit, Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    J Pediatr 158:897-903.e1-5. 2011
    ..To evaluate whether concentrations of inflammation-related proteins are elevated in the blood of preterm newborns who develop cerebral white matter damage...
  54. ncbi A single conserved proline residue determines the membrane topology of stomatin
    Ivan Kadurin
    Institute of Physiology II, University of Wurzburg, Röntgenring 9, Wurzburg, Germany
    Biochem J 418:587-94. 2009
    ..The single-pass transmembrane form exists also for SLP-3 and it should be considered that it mediates part of the physiological functions of stomatin and related proteins...
  55. ncbi Dietary patterns and ethnicity are associated with distinct plasma proteomic groups
    Bibiana Garcia-Bailo
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
    Am J Clin Nutr 95:352-61. 2012
    ..However, little is known about how concentrations of many plasma proteins vary between individuals from different ethnocultural groups with different dietary habits...
  56. pmc Sampling the N-terminal proteome of human blood
    David Wildes
    Department of Pharmaceutical Chemistry, University of California, San Francisco, Byers Hall, 1700 4th Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:4561-6. 2010
    ..to a large number of cleavages that have not been reported previously, including over 200 cleavages of blood proteins by aminopeptidases...
  57. ncbi Elevated plasma levels of antimicrobial polypeptides in patients with severe sepsis
    Ingrid Berkestedt
    Department of Anaesthesiology and Intensive Care, Lund University, and Lund University Hospital, Lund, Sweden
    J Innate Immun 2:478-82. 2010
    ..In conclusion, levels of several AMPs are increased in sepsis and correlate with circulatory derangement. This probably reflects neutrophil activation as part of an innate immune response...
  58. ncbi Deficient expression of bactericidal/permeability-increasing protein in immunocompromised hosts: translational potential of replacement therapy
    Christine D Palmer
    Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Biochem Soc Trans 39:994-9. 2011
    ....
  59. ncbi Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery
    John M Koomen
    Department of Molecular Pathology, University of Texas, M D Anderson Cancer Center, 0089, UT M D, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    J Proteome Res 4:972-81. 2005
    ..On the basis of these data, we discuss limitations in biomarker discovery in the low molecular weight plasma or serum proteome using crude fractionation coupled to MALDI-MS profiling...
  60. ncbi From infection to autoimmunity: a new model for induction of ANCA against the bactericidal/permeability increasing protein (BPI)
    Hendrik Schultz
    Division of Infectious Diseases, Department of Internal Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive SW54 GH, Iowa City, Iowa 52242 1081, USA
    Autoimmun Rev 6:223-7. 2007
    ....
  61. pmc Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis
    Daniel P Gale
    Division of Medicine, University College, London, UK
    Lancet 376:794-801. 2010
    ..We aimed to establish the genetic basis for a familial disorder of complement regulation associated with persistent microscopic haematuria, recurrent macroscopic haematuria, glomerulonephritis, and progressive renal failure...
  62. ncbi Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degeneration
    Katharina E Schmid-Kubista
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Invest Ophthalmol Vis Sci 50:5070-9. 2009
    ....
  63. ncbi Depletion of multiple high-abundance proteins improves protein profiling capacities of human serum and plasma
    Lynn A Echan
    The Wistar Institute, Philadelphia, PA 19104, USA
    Proteomics 5:3292-303. 2005
    ..This study compared a recently commercialized HPLC column containing antibodies to six of the most abundant blood proteins ("Top-6 depletion") with either older Cibacron blue/Protein A or G depletion methods or no depletion...
  64. ncbi Serum fetuin-A in nondialyzed patients with diabetic nephropathy: relationship with coronary artery calcification
    Rajnish Mehrotra
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Kidney Int 67:1070-7. 2005
    ..Fetuin-A is the most potent circulating inhibitor of calcium phosphorus precipitation and, possibly, an important mediator of insulin resistance...
  65. ncbi Comparison of protein enrichment strategies for proteome analysis of plasma
    Julia E Bandow
    Pfizer Global Research and Development, Pfizer Inc, Ann Arbor, MI, USA
    Proteomics 10:1416-25. 2010
    ..However, detectable protein spots in the different plasma fractions contained exclusively high-abundant proteins normally present in plasma at concentrations between 1 microg and 40 mg/mL...
  66. pmc Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations
    David M Rissin
    Quanterix Corporation, Cambridge, Massachusetts, USA
    Nat Biotechnol 28:595-9. 2010
    ..Digital ELISA detected prostate-specific antigen (PSA) in sera from patients who had undergone radical prostatectomy at concentrations as low as 14 fg/ml (0.4 fM)...
  67. pmc Isolation of a protein Z-dependent plasma protease inhibitor
    X Han
    Division of Hematology, Barnes Jewish Hospital at Washington University School of Medicine, 216 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 95:9250-5. 1998
    ..The inhibitory process appears to involve the formation of a factor Xa-PZ-ZPI complex at the phospholipid surface...
  68. ncbi Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
    K Takahashi
    Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita 565, Japan
    J Biol Chem 272:23371-5. 1997
    ..These results suggest that ERM as well as Rho GDI and the Rho GDP/GTP exchange factor are involved in the activation of the Rho subfamily members, which then regulate reorganization of actin filaments through the ERM system...
  69. ncbi Proteomic technologies for the identification of disease biomarkers in serum: advances and challenges ahead
    Sandipan Ray
    Wadhwani Research Center for Biosciences and Bioengineering, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India
    Proteomics 11:2139-61. 2011
    ..In this article, we will discuss the current status of serum proteome analysis for the biomarker discovery and address key technological advancements, with a focus on challenges and amenable solutions...
  70. ncbi Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4
    C A Blanchong
    Children s Research Institute, 700 Children s Drive, Columbus, OH 43205 2696, USA
    Int Immunopharmacol 1:365-92. 2001
    ..An undesirable accompanying byproduct of this phenomenon is the inherent deleterious recombinations among the RCCX constituents leading to autoimmune and genetic disorders...
  71. ncbi Stomatin-domain proteins
    Liudmilla Lapatsina
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13092 Berlin Buch, Germany
    Eur J Cell Biol 91:240-5. 2012
    ..Future studies into the precise structure and mechanism of stomatin-like proteins need to address these important questions to clarify the detailed cellular function of stomatin-domain containing proteins...
  72. ncbi Isolation of cDNA coding for an ubiquitous membrane protein deficient in high Na+, low K+ stomatocytic erythrocytes
    G W Stewart
    Department of Medicine, University College and Middlesex Medical School, Rayne Institute, London, UK
    Blood 79:1593-601. 1992
    ..As a membrane-bound inhibitor protein of Na+ and K+ transport, it is unique among the known components of membrane-transport proteins...
  73. ncbi Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke: the Edinburgh Artery Study
    Ioanna Tzoulaki
    Wolfson Unit for Prevention of Peripheral Vascular Diseases, Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Circulation 115:2119-27. 2007
    ....
  74. ncbi Combined approach of hematological biomarkers and plasma protein SAA for improvement of radiation dose assessment triage in biodosimetry applications
    Natalia I Ossetrova
    AFRRI, SRD, 8901 Wisconsin Avenue, Bethesda, MD 20889 5603, USA
    Health Phys 98:204-8. 2010
    ....
  75. ncbi Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles
    Hans Tapper
    Department of Cell and Molecular Biology, Lund University, Sweden
    Blood 99:1785-93. 2002
    ..The ability of neutrophils to secrete HBP from secretory vesicles may be important for proinflammatory functions of this protein, such as the alteration of vascular permeability...
  76. ncbi Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes
    N Ahmed
    Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
    Diabetologia 48:1590-603. 2005
    ....
  77. ncbi Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines
    J Krijgsveld
    Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    J Biol Chem 275:20374-81. 2000
    ..Killing of B. subtilis by either TC appeared to be very rapid. Because TCs were unable to dissipate the membrane potential of L. lactis, the mechanism of TC-mediated killing most probably does not involve pore formation...
  78. pmc Molecular diversity of antimicrobial effectors in the oyster Crassostrea gigas
    Paulina Schmitt
    IFREMER, CNRS, Universite de Montpellier II, IRD, UMR 5119 Ecosystèmes Lagunaires, Place Eugene Bataillon, CC80, 34095 Montpellier, France
    BMC Evol Biol 10:23. 2010
    ..For that, we analyzed genomic and transcript sequences obtained by specific PCR amplification and in silico searches...
  79. ncbi Two-dimensional difference gel electrophoresis (DiGE) analysis of plasmas from dengue fever patients
    Lidiane M Albuquerque
    Lab Toxinologia and Lab Imunofarmacologia, Pavilhao Ozorio de Almeida, Instituto Oswaldo Cruz and Instituto de Pesquisa Clinica Evandro Chagas, FIOCRUZ, Av Brasil 4365, 21040 900 Rio de Janeiro, Brazil
    J Proteome Res 8:5431-41. 2009
    ..The possible involvement of these proteins in the inflammatory process triggered by dengue virus infection and in the repair mechanisms of vascular damage occurring in this pathology is discussed in this study...
  80. ncbi Serum protein profiling in mice: identification of Factor XIIIa as a potential biomarker for muscular dystrophy
    Sharmini Alagaratnam
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Proteomics 8:1552-63. 2008
    ..This work underlines the translational aspect of serum protein profiling in mice and supports a further study with serum from patients with neuromuscular disorders...
  81. ncbi Serum peptidome profiling revealed platelet factor 4 as a potential discriminating Peptide associated with pancreatic cancer
    Georg Martin Fiedler
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
    Clin Cancer Res 15:3812-9. 2009
    ....
  82. ncbi Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISA
    J C ter Steege
    Department of Pediatrics, Academic Hospital Maastricht, The Netherlands
    Free Radic Biol Med 25:953-63. 1998
    ..0 +/- 28.2 microM in celiac disease patients. Both nitrotyrosine and NOx levels declined when the patients were on a gluten-free diet, suggesting a relation between intestinal inflammation and plasma nitrotyrosine and NOx levels...
  83. pmc High dynamic range characterization of the trauma patient plasma proteome
    Tao Liu
    Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99354, USA
    Mol Cell Proteomics 5:1899-913. 2006
    ....
  84. pmc Depletion of abundant plasma proteins and limitations of plasma proteomics
    Chengjian Tu
    The Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Proteome Res 9:4982-91. 2010
    ..Untargeted proteomic analyses using current LC-MS/MS platforms-even with immunodepletion-cannot be expected to efficiently discover low-abundance, disease-specific biomarkers in plasma...
  85. pmc Computational prediction of human proteins that can be secreted into the bloodstream
    Juan Cui
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Bioinformatics 24:2370-5. 2008
    ..Our study demonstrated that our method can provide highly useful information to link genomic and proteomic studies for disease biomarker discovery. Our software can be accessed at http://csbl1.bmb.uga.edu/cgi-bin/Secretion/secretion.cgi...
  86. ncbi PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx
    Colin D Bingle
    Respiratory Medicine Unit, Division of Genomic Medicine, University of Sheffield Medical School, Sheffield, S10 2RX, UK
    Hum Mol Genet 11:937-43. 2002
    ..We suggest that members of the PLUNC family may function in the innate immune response in regions of the mouth, nose and lungs, which are sites of significant bacterial exposure...
  87. pmc betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system
    S Berghs
    Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cell Biol 151:985-1002. 2000
    ..Thus, we suggest that betaIVSigma1 spectrin interacts with ankyrin(G) 480/270-kD and participates in the clustering of voltage-gated Na(+) channels and cell-adhesion molecules at initial segments and nodes of Ranvier...
  88. ncbi Clinical indications for plasma protein assays: transthyretin (prealbumin) in inflammation and malnutrition
    A Myron Johnson
    Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC 27410, USA
    Clin Chem Lab Med 45:419-26. 2007
    ..In addition to these caveats, assays for TTR have a relatively high level of uncertainty ("imprecision"). Clinical evaluation--history and physical examination--should remain the mainstay of nutritional assessment...
  89. ncbi High throughput quantitative analysis of serum proteins using glycopeptide capture and liquid chromatography mass spectrometry
    Hui Zhang
    Institute for Systems Biology, Seattle, WA 98103, USA
    Mol Cell Proteomics 4:144-55. 2005
    ..We further identify, by tandem mass spectrometry, some of the peptides that were consistently elevated in cancer mice compared with their control littermates...
  90. pmc Bladder cancer associated glycoprotein signatures revealed by urinary proteomic profiling
    Paweena Kreunin
    Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA
    J Proteome Res 6:2631-9. 2007
    ....
  91. pmc Development of multimarker panel for early detection of endometrial cancer. High diagnostic power of prolactin
    Zoya Yurkovetsky
    University of Pittsburgh Cancer Institute, Hillman Cancer Center, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    Gynecol Oncol 107:58-65. 2007
    ..Therefore, prevention and early detection may further reduce the burden of this challenging disease...
  92. pmc Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells
    Maria Ruzzene
    Dipartimento di Chimica Biologica, Universita di Padova, Viale G Colombo, 3 35121 Padova, Italy
    Biochem J 364:41-7. 2002
    ....
  93. pmc A serum protein-based algorithm for the detection of Alzheimer disease
    Sid E O'Bryant
    Texas Tech University Health Science Center, Department of Neurology, Lubbock, TX 79430, USA
    Arch Neurol 67:1077-81. 2010
    ..To develop an algorithm that separates patients with Alzheimer disease (AD) from controls...
  94. pmc Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A
    Bernd Denecke
    Interdisciplinary Center for Clinical Research on Biomaterials IZKF BIOMAT, University Hospital, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Biochem J 376:135-45. 2003
    ..Therefore fetuin-B may have a function that is partly overlapping, if not identical, with the function of fetuin-A...
  95. ncbi alpha 2-HS glycoprotein/fetuin, a transforming growth factor-beta/bone morphogenetic protein antagonist, regulates postnatal bone growth and remodeling
    Melanie Szweras
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 277:19991-7. 2002
    ..Our results demonstrate that ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis...
  96. ncbi Identification of serum biomarkers in brain-injured adults: potential for predicting elevated intracranial pressure
    Georgene Hergenroeder
    Vivian L Smith Center for Neurologic Research, University of Texas Medical School, Houston, TX, USA
    J Neurotrauma 25:79-93. 2008
    ..Our results support the use of serum as a source for discovery of TBI biomarkers, and indicate that serum biomarkers may have utility for predicting secondary pathologies (e.g., elevated ICP) associated with TBI...
  97. ncbi Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation
    Sumie Manno
    Department of Biochemistry, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Biol Chem 280:7581-7. 2005
    ..These findings have enabled us to define a regulatory role for 4.1R phosphorylation in dynamic regulation of red cell membrane properties...
  98. pmc Down-regulation of PROS1 gene expression by 17beta-estradiol via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex
    Atsuo Suzuki
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya 461 8673, Japan
    J Biol Chem 285:13444-53. 2010
    ....
  99. ncbi Membrane and juxtamembrane targeting by PH and PTB domains
    Jonathan P DiNitto
    Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Two Biotech, Worcester, MA 01605, USA
    Biochim Biophys Acta 1761:850-67. 2006
    ..In this review, we highlight unifying recognition principles and further illustrate with examples how divergent mechanisms contribute to membrane and juxtamembrane targeting by PH and PTB domains...
  100. pmc Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood
    Rong Fan
    NanoSystems Biology Cancer Center, California Institute of Technology, MC 127 72, 1200 E California Blvd, Pasadena, California 91125, USA
    Nat Biotechnol 26:1373-8. 2008
    ..Our device holds potential for inexpensive, noninvasive and informative clinical diagnoses, particularly in point-of-care settings...
  101. ncbi Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells
    P Varnai
    Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Biol Chem 274:10983-9. 1999
    ....

Research Grants70

  1. Development of SPR/MS protein array platform
    Dobrin Nedelkov; Fiscal Year: 2007
    ..abstract_text> ..
  2. Development of SPR/MS protein array platform
    Dobrin Nedelkov; Fiscal Year: 2005
    ....
  3. Affinity-based Mass Spectrometry Protein Assays
    Dobrin Nedelkov; Fiscal Year: 2004
    ..abstract_text> ..
  4. CHROMATOGRAPHIC STUDIES OF FUNCTIONAL PROTEOMICS
    DAVID HAGE; Fiscal Year: 2009
    ..This, in turn, should allow an improved description of how the transport, metabolism, and effective dose of a drug will differ between a diabetic patient and an individual without diabetes. ..
  5. Proteomic Analysis of Retinal Ganglion Cell Death in Glaucoma
    GULGUN TEZEL; Fiscal Year: 2010
    ..These studies are expected to provide comprehensive information about the nerve cell death process, thereby allowing new treatment possibilities for 3 million Americans suffering from glaucoma. ..
  6. Homocysteine: Vascular Biochemistry and Metabolism
    DONALD JACOBSEN; Fiscal Year: 2005
    ..This aim is driven by the hypothesis that homocysteine alters vascular cell function by targeting and modulating the activity of specific molecules on and within the cell. ..
  7. PE BIOSYSTEMS VOYAGER DE MALDI-TOF
    Kenneth Mann; Fiscal Year: 2001
    ..The fulfillment of the specific aims described in detail in the twelve research proposals would be facilitated by the addiction of a Voyager-DE MALDI-TOF ..
  8. Vascular Biochemistry of Vitamin B12
    DONALD JACOBSEN; Fiscal Year: 2006
    ..abstract_text> ..
  9. Phase I Clinical Trials of Anti-Cancer Agents
    Francis Giles; Fiscal Year: 2007
    ..abstract_text> ..
  10. Gene Therapy for Neurological Diseases
    Pedro Lowenstein; Fiscal Year: 2006
    ..abstract_text> ..
  11. MOLECULAR BASIS OF COAGULATION PROTEASE SPECIFICITY
    Alireza R Rezaie; Fiscal Year: 2010
    ....
  12. Antiretroviral-Induced Defects in Muscle Protein Synthesis
    Charles H Lang; Fiscal Year: 2010
    ..Such data is needed to both realize the full potential and avoid possible pitfalls of this drug in the long-term treatment of HIV-infected individuals. ..
  13. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2007
    ..whether increased SOD1 in transgenic mice protects against hypertension similar to tempol; d. the role of NADPH oxidase, by measuring p22 phox expression and the effect of apocynin. ..
  14. A PCT Sample Preparation System for Proteomic Research and Clinical Diagnostics
    Feng Tao; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  15. Colonoscopy Utilization in North Carolina
    David Ransohoff; Fiscal Year: 2006
    ..It may provide the basis to develop interventions to optimize the allocation of colonoscopy effort in programs of CRC screening and surveillance. ..
  16. Treatment of Crohn's Disease with Growth Hormone
    Tamara Hannon; Fiscal Year: 2006
    ....
  17. MECHANISMS OF CELL INJURY IN BURN COMPLICATED BY SEPSIS
    Deborah Carlson; Fiscal Year: 2006
    ..The proposed work focuses on five specific aims to increase our understanding of the cellular events involved in burn and sepsis-related myocardial injury. ..
  18. INTEGRATE/PHARMACOKINETIC/ANTIRETROVIRUS RESISTANCE TEST
    Edward Acosta; Fiscal Year: 2006
    ..abstract_text> ..
  19. Progesterone regulation of human luteal cell viability
    John Peluso; Fiscal Year: 2006
    ..Such selective manipulation of the P4's actions could have far reaching effects on the treatment for infertility, contraception and certain types of cancers. [unreadable] [unreadable]..
  20. Nucleic Acid Purification Using Pressure Cycling Technology
    Feng Tao; Fiscal Year: 2007
    ..If successful, this technology could be immediately employed in many fields of life sciences. [unreadable] [unreadable] [unreadable]..
  21. Rapid and Inexpensive Biochip Based Allergy Testing
    Bryce Nelson; Fiscal Year: 2007
    ..The goal of the Phase II project is to develop a allergy biochip that is capable of providing accurate results rapidly with little patient discomfort. [unreadable] [unreadable]..
  22. Cellular and Molecular Mechanisms of Vascular Permeability
    RADU STAN; Fiscal Year: 2009
    ..The techniques employed are cell fractionation, biochemical assays, cell free-assays, in-vivo transport studies, genetically modified animal models, cell culture, transfections, light and electron microscopy. ..
  23. MMP-2 in Periodontal Disease and Oral Cancer
    Bjorn Steffensen; Fiscal Year: 2008
    ..The proposed studies should define the specific binding sites of MMP-2 and collagen and explore a new strategy to inhibit MMP-2 in periodontal disease and oral cancer. ..
  24. Nephrology Training Grant
    Scott Thomson; Fiscal Year: 2008
    ..An interactive research environment and shared seminar programs between UCSD, Salk Institute, and numerous other research institutes in La Jolla further enhances the training program. ..
  25. Resolution of Gouty Inflammation
    STEPHEN MALAWISTA; Fiscal Year: 2008
    ..We suggest further that this reprogramming of lipid mediators may explain in part the action of therapeutic agents such as colchicine, and could lead to better treatment for this condition. [unreadable] [unreadable] [unreadable]..
  26. Membrane Transport of NH3 and NH4+
    NAZIH NAKHOUL; Fiscal Year: 2008
    ..These are new properties of NH3/NH4+ transport that will help explain the role of NH3 and NH4+ in acidosis and their effect on transport of other ions a well. ..
  27. PRIMARY STRUCTURE OF PROTHROMBIN
    Kenneth Mann; Fiscal Year: 2008
    ..The major aim of this project is to elucidate the structure/function relationships of this material with respect to factor V inactivation and to access its potential significance in the pathology of human thrombosis. ..
  28. Gene Delivery into Human Hematopoietic Cells
    Arthur Bank; Fiscal Year: 2008
    ..The gene delivery technology should also be applicable for use in treating other human diseases as well. ..
  29. Removal of Protein-Bound Solutes by Dialysis
    Timothy Meyer; Fiscal Year: 2007
    ..The proposed ancillary study to the FHN will provide a unique opportunity to relate protein-bound solute levels to other chemical parameters and indices of well-being in a large group of hemodialysis patients. ..
  30. Hereditary Hemolytic Anemia: A Proteomic Approach
    JASON WOODEN; Fiscal Year: 2007
    ..We hope that a deeper understanding of protein-protein interactions within the RBC can provide new insights into inherited hemolytic anemia. ..
  31. MMP-2 and Fibronectin Fragmentation in Periodontal Diseases and Oral Cancer
    Bjorn Steffensen; Fiscal Year: 2010
    ..Successful inhibition of fibronectin fragmentation could be of significant benefit for the management of both periodontal disease and oral cancer. ..
  32. Pharmacogenetics of Antidepressant Drugs
    Ma Li Wong; Fiscal Year: 2007
    ..This K-24 award will make possible for the P.I. to significantly increase her time allocation for patient-oriented research and for mentoring of junior trainees and fellows in clinical research. [unreadable] [unreadable]..
  33. Substance Abuse and HIV: Genetics and Disease Progression
    Howard Crystal; Fiscal Year: 2009
    ..Using all relevant longitudinal data, we will evaluate the effects of gene polymorphisms on the risk of persistent substance abuse, on progression to AIDS and to death, and on the risk of depression. ..
  34. COLLAGEN BIOSYNTHESIS OF CULTURED FIBROBLASTS
    Jouni Uitto; Fiscal Year: 2006
    ....
  35. Mechanisms Progression in Renal Insufficiency
    Timothy Meyer; Fiscal Year: 2006
    ..These studies, like those of endocytosis, will employ knockout mice to assess the importance of potential mediators of injury which are not yet subject to pharmacologic manipulation. ..
  36. Transciption Factor Interactions Using Addressed Arrays
    Bryce Nelson; Fiscal Year: 2004
    ..In Phase II, we plan to expand the scope of the research described in this Phase I proposal by increasing the density of the DNA LineArrays and microchannels and by studying DNA binding activities of cellular extracts. ..
  37. Symphony Multiplex Peptide Synthesizer w/ VISION Workstn
    Kenneth Mann; Fiscal Year: 2004
    ..There is currently no preparative HPLC system on the campus of the University of Vermont and this system is badly needed for many investigators. ..
  38. PERMSELECTIVE PROPERTIES OF TUMOR AND WOUND BLOOD VESSEL
    HAROLD DVORAK; Fiscal Year: 2004
    ..abstract_text> ..
  39. Maximize RAS Blockade in Diabetic Nephropathy
    Timothy Meyer; Fiscal Year: 2003
    ..But the number of such trials which can be performed is limited. Short term trials, such as those described in this proposal, are urgently required to help identify treatment regimens which merit further, longer term study. ..
  40. LYME DISEASE--HOST PARASITE INTERACTIONS
    STEPHEN MALAWISTA; Fiscal Year: 2003
    ..These studies may provide the technical and conceptual basis for improvements in diagnostic and prognostic aspects of inflammatory diseases. ..
  41. Tissue Homogenizaton by Pressure Cycling Technology
    Feng Tao; Fiscal Year: 2003
    ..The successful development of the PCT homogenization technology will benefit molecular based analytical procedures in genomics, medical, forensic, agricultural, pharmaceutical, veterinary and clinical applications ..
  42. Biomarker Chip for Osteoarthritis
    Stephen Kingsmore; Fiscal Year: 2002
    ..We also will identify other reagents as potentially useful biomarkers for OA with the aim of designing an OA chip. ..
  43. CNS transcription modulation in peripheral inflammation
    Ma Li Wong; Fiscal Year: 2002
    ..The proposed studies will result in new data that will be needed for us to generate novel testable hypotheses, which will provide the framework for future R0l applications. ..
  44. HUMAN GLOBIN GENE TRANSFER AND EXPRESSION
    Arthur Bank; Fiscal Year: 2002
    ....
  45. IMMUNE PEPTIDES IN AEDES AEGYPTI
    TIMOTHY YOSHINO; Fiscal Year: 2002
    ....
  46. PHYSIOLOGY OF RENAL SODIUM/BICARBONATE COTRANSPORT
    Walter Boron; Fiscal Year: 2001
    ..The use of isolated, perfused tubules will insure that the expression of the transporters is as normal as possible, and that anatomical origin of the tubules is precisely known. ..
  47. HUPO 2nd Annual World Congress Montreal 2003
    Samir Hanash; Fiscal Year: 2003
    ....
  48. CLINICAL RESEARCH CURRICULUM
    David Ransohoff; Fiscal Year: 2004
    ..abstract_text> ..
  49. Regulation of Oocyte Viability by Granulosa Cell Contact
    John Peluso; Fiscal Year: 2004
    ..abstract_text> ..
  50. The Glycosylation Gap and Diabetic Complications
    Robert Cohen; Fiscal Year: 2005
    ..The proposal therefore has potentially important basic science, clinical and population implications. ..
  51. Induced hypothermic arrest in traumatic shock
    Hasan Alam; Fiscal Year: 2005
    ..Sub aim 2: Develop and test methods and techniques that can facilitate the induction of hypothermic arrest in the setting of traumatic shock. ..
  52. MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS
    T O SHEA; Fiscal Year: 2005
    ..abstract_text> ..
  53. Alveolar Epithelium in Acute Lung Injury
    Lorraine Ware; Fiscal Year: 2005
    ..Combined with a compelling research project, the training will -provide the skills necessary for a successful career in biomedical research. ..
  54. Role of TIMAP in Vascular Development and Function
    BARBARA BALLERMANN; Fiscal Year: 2005
    ..The current proposal explores the possibility that TIMAP represents a critical component of a 67LR signaling pathway, and thereby is involved in regulating endothelial cell motility, tube formation, and apoptosis. ..
  55. REGULATION OF HUMAN GLOBIN GENE EXPRESSION
    Arthur Bank; Fiscal Year: 2004
    ..abstract_text> ..
  56. Novel antibacterial agents for treatment of Tularemia
    Nachum Kaplan; Fiscal Year: 2004
    ..tularensis microbiological data and animal model data to warrant inclusion of the information on the product label as a narrow spectrum agent that could be used in the event of a F. tularensis release. ..
  57. Gene Therapy for Glioma
    Pedro Lowenstein; Fiscal Year: 2004
    ..Our long term aim is to translate this novel therapeutic approach into a Phase I clinical trial for GBM. ..
  58. Decision Support Systems for MAG3 Renography
    Andrew Taylor; Fiscal Year: 2005
    ..abstract_text> ..
  59. 12th International Symposium on Basement Membranes
    Jouni Uitto; Fiscal Year: 2005
    ..In that sense, the meeting will meet some of the goals of the National Institutes of Health Roadmap Initiative. ..
  60. Endonuclease dificiency in breast cancer progression
    Alexei Basnakian; Fiscal Year: 2006
    ..The next specific aim will be focused on functional studies to determine the role of EndoG in dedifferentiation and invasiveness of breast cancer cells in vitro (Specific Aim 2). ..
  61. WAVE DNA Fragment Analysis System
    Jouni Uitto; Fiscal Year: 2001
    ..It is highly suitable for analysis of a set of genes in a large number of individuals as well as identification of mutations and polymorphisms in many genes of interest. ..
  62. ADENOVIRAL VECTORS FOR DELIVERY OF ANGIOGENIC CYTOKINES
    HAROLD DVORAK; Fiscal Year: 2008
    ..Aim 2. Elucidate the mechanisms by which mother vessels evolve into daughter vessels. Aim 3. Generate normal blood vessels with mixtures of primary and secondary cytokines. ..
  63. Molecular Genetics of Familial Tumoral Calcinosis
    Jouni Uitto; Fiscal Year: 2009
    ..abstract_text> ..
  64. CO POISONING IN THE CONTEXT OF A REPERFUSION INJURY
    Stephen Thom; Fiscal Year: 2003
    ..The research plan is aimed to test the hypothesis that immune responses and the associated oxidative stress cause neurological injuries. ..
  65. Arterial 5-HT Transporter Function
    Stephanie Watts; Fiscal Year: 2009
    ..abstract_text> ..
  66. RED CELL CYTOSKELETAL PROTEIN AND MITOSIS
    Shu Ching Huang; Fiscal Year: 2008
    ..Finally, we shall define the relationship between changes in the expression of these 4.1R isoforms and the transition from proliferation to post-mitotic states during erythroid differentiation. ..
  67. Frontotemporal degeneration: a basis for clinical trials
    David Knopman; Fiscal Year: 2006
    ..abstract_text> ..
  68. Neuroprotective Role of Fetuin in Cerebral Ischemia
    Haichao Wang; Fiscal Year: 2008
    ..Answers to these questions will improve our understanding of the pathophysiology of ischemic neural injury, and identify novel therapeutic agents for the treatment of stroke and related disorders. ..