coagulase

Summary

Summary: Enzymes that cause coagulation in plasma by forming a complex with human PROTHROMBIN. Coagulases are produced by certain STAPHYLOCOCCUS and YERSINIA PESTIS. Staphylococci produce two types of coagulase: Staphylocoagulase, a free coagulase that produces true clotting of plasma, and Staphylococcal clumping factor, a bound coagulase in the cell wall that induces clumping of cells in the presence of fibrinogen.

Top Publications

  1. ncbi Distribution of staphylococcal cassette chromosome mec (SCCmec) types I, II, III and IV in coagulase-negative staphylococci from patients attending a tertiary hospital in southern Brazil
    Alice Beatriz Mombach Pinheiro Machado
    Unidade de Microbiologia e Biologia Molecular, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90 035 903, Brazil
    J Med Microbiol 56:1328-33. 2007
  2. ncbi Coagulase-negative staphylococcal infections
    Kathie L Rogers
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 986280 Nebraska Medical Center, Omaha, NE 68198 6280, USA
    Infect Dis Clin North Am 23:73-98. 2009
  3. pmc Diversity of SCCmec elements in methicillin-resistant coagulase-negative staphylococci clinical isolates
    Zhiyong Zong
    Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
    PLoS ONE 6:e20191. 2011
  4. ncbi Coagulase-negative staphylococci: update on the molecular epidemiology and clinical presentation, with a focus on Staphylococcus epidermidis and Staphylococcus saprophyticus
    M Widerström
    Department of Infectious Diseases, Ostersund Hospital, Ostersund, Sweden
    Eur J Clin Microbiol Infect Dis 31:7-20. 2012
  5. pmc Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections
    Molly McAdow
    Department of Microbiology, University of Chicago, Chicago, Ill 60637, USA
    J Innate Immun 4:141-8. 2012
  6. ncbi Role of coagulase-negative staphylococci in human disease
    A Piette
    Department of Microbiology, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium
    Vet Microbiol 134:45-54. 2009
  7. pmc Evolution of nasal carriage of methicillin-resistant coagulase-negative staphylococci in a remote population
    David Lebeaux
    Bacteriology Unit and French National Reference Center for Bacterial Resistance in Commensal Flora, Diderot Paris 7 University and Bichat Claude Bernard Teaching Hospital Assistance Publique Hôpitaux de Paris, Paris, France
    Antimicrob Agents Chemother 56:315-23. 2012
  8. ncbi Prevalence of antiseptic-resistance genes in Staphylococcus aureus and coagulase-negative staphylococci colonising nurses and the general population in Hong Kong
    M Zhang
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, China
    J Hosp Infect 78:113-7. 2011
  9. pmc Prevalence and characteristics of methicillin-resistant coagulase-negative staphylococci from livestock, chicken carcasses, bulk tank milk, minced meat, and contact persons
    Helen Huber
    Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Winterthurerstrasse 272, 8057 Zurich, Switzerland
    BMC Vet Res 7:6. 2011
  10. ncbi Methicillin-resistant coagulase-negative staphylococci in the community: high homology of SCCmec IVa between Staphylococcus epidermidis and major clones of methicillin-resistant Staphylococcus aureus
    Francois Barbier
    Bacteriology Unit and National Reference Center for Emergence of Resistance in Commensal Flora, 2EA 3964, Bichat Claude Bernard Hospital, Assistance Publique Hôpitaux de Paris and Xavier Bichat Medical School, Denis Diderot Paris 7 University, Paris, France
    J Infect Dis 202:270-81. 2010

Detail Information

Publications333 found, 100 shown here

  1. ncbi Distribution of staphylococcal cassette chromosome mec (SCCmec) types I, II, III and IV in coagulase-negative staphylococci from patients attending a tertiary hospital in southern Brazil
    Alice Beatriz Mombach Pinheiro Machado
    Unidade de Microbiologia e Biologia Molecular, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90 035 903, Brazil
    J Med Microbiol 56:1328-33. 2007
    b>Coagulase-negative staphylococci (CoNS) are now recognized as the aetiological agents of an important range of infections in humans...
  2. ncbi Coagulase-negative staphylococcal infections
    Kathie L Rogers
    Department of Pathology and Microbiology, University of Nebraska Medical Center, 986280 Nebraska Medical Center, Omaha, NE 68198 6280, USA
    Infect Dis Clin North Am 23:73-98. 2009
    b>Coagulase-negative staphylococci (CNS) are differentiated from the closely related but more virulent Staphylococcus aureus by their inability to produce free coagulase. Currently, there are over 40 recognized species of CNS...
  3. pmc Diversity of SCCmec elements in methicillin-resistant coagulase-negative staphylococci clinical isolates
    Zhiyong Zong
    Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China
    PLoS ONE 6:e20191. 2011
    Methicillin-resistant coagulase-negative staphylococci (MR-CoNS) are opportunistic pathogens and serve as a large reservoir of staphylococcal cassette chromosome mec (SCCmec)...
  4. ncbi Coagulase-negative staphylococci: update on the molecular epidemiology and clinical presentation, with a focus on Staphylococcus epidermidis and Staphylococcus saprophyticus
    M Widerström
    Department of Infectious Diseases, Ostersund Hospital, Ostersund, Sweden
    Eur J Clin Microbiol Infect Dis 31:7-20. 2012
    b>Coagulase-negative staphylococci (CoNS), originally described as ubiquitous commensals of the healthy human skin and mucosa, have emerged as important opportunistic pathogens primarily causing healthcare-associated infections in patients ..
  5. pmc Staphylococcus aureus secretes coagulase and von Willebrand factor binding protein to modify the coagulation cascade and establish host infections
    Molly McAdow
    Department of Microbiology, University of Chicago, Chicago, Ill 60637, USA
    J Innate Immun 4:141-8. 2012
    ..Two staphylococcal products, the canonical coagulase (Coa) as well as the recently identified von Willebrand factor binding protein (vWbp), promote similar ..
  6. ncbi Role of coagulase-negative staphylococci in human disease
    A Piette
    Department of Microbiology, University Hospital Ghent, De Pintelaan 185, 9000 Ghent, Belgium
    Vet Microbiol 134:45-54. 2009
    b>Coagulase-negative staphylococci (CNS) are normal inhabitants of human skin and mucous membranes...
  7. pmc Evolution of nasal carriage of methicillin-resistant coagulase-negative staphylococci in a remote population
    David Lebeaux
    Bacteriology Unit and French National Reference Center for Bacterial Resistance in Commensal Flora, Diderot Paris 7 University and Bichat Claude Bernard Teaching Hospital Assistance Publique Hôpitaux de Paris, Paris, France
    Antimicrob Agents Chemother 56:315-23. 2012
    Nasal carriage of methicillin-resistant coagulase-negative staphylococci (MR-CoNS) is highly prevalent in community subjects, but its dynamic has been little investigated...
  8. ncbi Prevalence of antiseptic-resistance genes in Staphylococcus aureus and coagulase-negative staphylococci colonising nurses and the general population in Hong Kong
    M Zhang
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, China
    J Hosp Infect 78:113-7. 2011
    ..Staphylococcus aureus and coagulase-negative staphylococci (CoNS) isolated from 249 nurses were compared for qacA/B and smr positivity with carriage ..
  9. pmc Prevalence and characteristics of methicillin-resistant coagulase-negative staphylococci from livestock, chicken carcasses, bulk tank milk, minced meat, and contact persons
    Helen Huber
    Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Winterthurerstrasse 272, 8057 Zurich, Switzerland
    BMC Vet Res 7:6. 2011
    Methicillin-resistant coagulase-negative staphylococci (MR-CNS) are of increasing importance to animal and public health...
  10. ncbi Methicillin-resistant coagulase-negative staphylococci in the community: high homology of SCCmec IVa between Staphylococcus epidermidis and major clones of methicillin-resistant Staphylococcus aureus
    Francois Barbier
    Bacteriology Unit and National Reference Center for Emergence of Resistance in Commensal Flora, 2EA 3964, Bichat Claude Bernard Hospital, Assistance Publique Hôpitaux de Paris and Xavier Bichat Medical School, Denis Diderot Paris 7 University, Paris, France
    J Infect Dis 202:270-81. 2010
    Data on community spread of methicillin-resistant coagulase-negative staphylococci (MR-CoNS) are scarce...
  11. pmc Contribution of coagulases towards Staphylococcus aureus disease and protective immunity
    Alice G Cheng
    Department of Microbiology, University of Chicago, Chicago, Illinois, United States of America
    PLoS Pathog 6:e1001036. 2010
    ..S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp)...
  12. pmc Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus and decreases complement-mediated phagocytosis
    Pamela S Hair
    Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Infect Immun 78:1717-27. 2010
    ..High levels of factor I binding by clinical strains correlated with poor phagocytosis. In summary, our results suggest that the interaction of ClfA with factor I contributes to S. aureus virulence by a complement-mediated mechanism...
  13. pmc Comparative assessment of antibiotic susceptibility of coagulase-negative staphylococci in biofilm versus planktonic culture as assessed by bacterial enumeration or rapid XTT colorimetry
    Nuno Cerca
    Centro de Engenharia Biólogica, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    J Antimicrob Chemother 56:331-6. 2005
    To quantitatively compare the antibiotic susceptibility of biofilms formed by the coagulase-negative staphylococci (CoNS) Staphylococcus epidermidis and Staphylococcus haemolyticus with the susceptibility of planktonic cultures.
  14. ncbi Coagulase-negative staphylococci: role as pathogens
    J Huebner
    Dept of Infectious Diseases, Children s Hospital, Boston, Massachusetts, USA
    Annu Rev Med 50:223-36. 1999
    b>Coagulase-negative staphylococci have long been regarded as apathogenic but their important role as pathogens and their increasing incidence have been recognized and studied in recent years...
  15. ncbi Periodontal status and bacteremia with oral viridans streptococci and coagulase negative staphylococci in allogeneic hematopoietic stem cell transplantation recipients: a prospective observational study
    Judith E Raber-Durlacher
    Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands
    Support Care Cancer 21:1621-7. 2013
    ..g., gingivitis and periodontitis) and the development of bacteremia during neutropenia following allogeneic hematopoietic stem cell transplantation (HSCT)...
  16. ncbi Bacterial substitution of coagulase-negative staphylococci for streptococci on the oral mucosa after hematopoietic cell transplantation
    Yoshihiko Soga
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Kita ku, Okayama, 700 8525, Japan
    Support Care Cancer 19:995-1000. 2011
    b>Coagulase-negative staphylococci (CoNS) are frequently isolated from blood cultures of hematopoietic cell transplantation (HCT) patients...
  17. ncbi Clinical and microbiological profile of persistent coagulase-negative staphylococcal bacteraemia in neonates
    G Dimitriou
    Neonatal Intensive Care Unit, Department of Paediatrics, School of Medicine, University of Patras, Patras, Greece
    Clin Microbiol Infect 17:1684-90. 2011
    An atypical pattern of coagulase-negative staphylococcal (CoNS) sepsis, characterized by persistence despite aggressive antibiotic therapy, has been described in neonates cared for in neonatal intensive-care units...
  18. ncbi Protection against experimental Staphylococcus aureus arthritis by vaccination with clumping factor A, a novel virulence determinant
    E Josefsson
    Department of Rheumatology, University of Goteborg, Goteborg, Sweden
    J Infect Dis 184:1572-80. 2001
    ..Taken together, these data strongly suggest that ClfA is a crucial virulence determinant for septic arthritis and an excellent target for the generation of immune therapies directed against S. aureus...
  19. ncbi Methicillin-resistant strains of Staphylococcus aureus and coagulase-negative staphylococus from clinical isolates at Felege Hiwot Refferal Hospital, North West Ethiopia
    Bayeh Abera
    Bahir Dar University, Medical Faculty of Education, P O Box, 1498 Bahir Dar
    Ethiop Med J 46:149-54. 2008
    ..Methicillin-resistant staphylococci are one of the major causes of nosocomial infection. The aim of this study was to determine Methicillin-resistant strain of staphylococci and its antibiotic resistance...
  20. ncbi Identification and methicillin resistance of coagulase-negative staphylococci isolated from nasal cavity of healthy horses
    Jolanta Karakulska
    Department of Immunology, Microbiology and Physiological Chemistry Faculty of Biotechnology and Animal Husbandry West Pomeranian University of Technology, Szczecin, Poland Doktora Judyma 24, 71 466, Szczecin, Poland
    J Microbiol 50:444-51. 2012
    ..8%) isolates susceptible to cefoxitin. In total, from 12 horses (28.6%), 17 (19.5%) MRCoNS were isolated. The highest percentage of MRCoNS was noted among S. sciuri isolates (100%)...
  21. ncbi Distribution and expression of macrolide resistance genes in coagulase-negative staphylococci
    S G Gatermann
    Abteilung für Medizinische Mikrobiologie, Ruhr Universitat Bochum, Bochum, Germany
    Clin Microbiol Infect 13:777-81. 2007
    In total, 494 isolates of coagulase-negative staphylococci (CoNS) were identified to the species level by biochemical tests and sodA sequencing...
  22. ncbi Detection of methicillin resistance in coagulase-negative staphylococci and in staphylococci directly from simulated blood cultures using the EVIGENE MRSA Detection Kit
    Ane B Poulsen
    Department of Microbiological R and D, Statens Serum Institut, Copenhagen, Denmark
    J Antimicrob Chemother 51:419-21. 2003
    The EVIGENE MRSA Detection Kit was evaluated on coagulase-negative staphylococci (CoNS) from agar plates and on staphylococci directly from positive spiked blood cultures...
  23. pmc Coagulase-negative staphylococci as reservoirs of genes facilitating MRSA infection: Staphylococcal commensal species such as Staphylococcus epidermidis are being recognized as important sources of genes promoting MRSA colonization and virulence
    Michael Otto
    Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD, USA
    Bioessays 35:4-11. 2013
    ..aureus contribute to survival in the human host, how they are transferred to S. aureus, and why this exchange appears to be uni-directional...
  24. ncbi Linezolid-resistant clinical isolates of meticillin-resistant coagulase-negative staphylococci and Enterococcus faecium from China
    Jia Chang Cai
    2nd Affiliated Hospital of Zhejiang University, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, PR China
    J Med Microbiol 61:1568-73. 2012
    Seventeen meticillin-resistant coagulase-negative staphylococci (MRCoNS), including ten Staphylococcus capitis, four Staphylococcus cohnii, two Staphylococcus haemolyticus and one Staphylococcus sciuri, and an Enterococcus faecium ..
  25. pmc Methicillin-resistant coagulase-negative staphylococci on pig farms as a reservoir of heterogeneous staphylococcal cassette chromosome mec elements
    Pawel Tulinski
    Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Appl Environ Microbiol 78:299-304. 2012
    ..aureus (MRSA) likely originated by acquisition of the staphylococcal cassette chromosome mec (SCCmec) from coagulase-negative staphylococci (CNS)...
  26. pmc Diversity of Staphylococcus species strains based on partial kat (catalase) gene sequences and design of a PCR-restriction fragment length polymorphism assay for identification and differentiation of coagulase-positive species (S. aureus, S. delphini, S.
    Giuseppe Blaiotta
    Department of Food Science, School of Agriculture, University of Naples Federico II, Via Universita 100, 80055 Portici, Italy
    J Clin Microbiol 48:192-201. 2010
    ..developed for rapid unequivocal identification/differentiation, at species and subspecies levels, of coagulase-positive staphylococci (CPS)...
  27. pmc Acceleration of the direct identification of Staphylococcus aureus versus coagulase-negative staphylococci from blood culture material: a comparison of six bacterial DNA extraction methods
    A J M Loonen
    PAMM Laboratory for Medical Microbiology, Eindhoven Veldhoven, The Netherlands
    Eur J Clin Microbiol Infect Dis 30:337-42. 2011
    To accelerate differentiation between Staphylococcus aureus and coagulase-negative staphylococci (CNS), this study aimed to compare six different DNA extraction methods from two commonly used blood culture materials, i.e...
  28. ncbi Coagulase-negative staphylococci as cause of bovine mastitis- not so different from Staphylococcus aureus?
    Suvi Taponen
    University of Helsinki, Department of Production Animal Medicine, Helsinki, Finland
    Vet Microbiol 134:29-36. 2009
    In this review of the literature, mastitis-causing coagulase-negative staphylococci (CNS) and Staphylococcus aureus are compared...
  29. pmc Regional profiling for determination of genotype diversity of mastitis-specific Staphylococcus aureus lineage in Canada by use of clumping factor A, pulsed-field gel electrophoresis, and spa typing
    Kamaleldin B Said
    McGill University, Montreal, Quebec, Canada
    J Clin Microbiol 48:375-86. 2010
    ..Thus, concordant with the results of PFGE and spa typing, clfA typing proved useful for revealing the clonal nature of the mastitis isolate lineage and for the rapid profiling of subpopulations with comparable discriminatory powers...
  30. pmc Multiple staphylococcal cassette chromosomes and allelic variants of cassette chromosome recombinases in Staphylococcus aureus and coagulase-negative staphylococci from Norway
    Anne Merethe Hanssen
    Department of Microbiology and Virology, Faculty of Medicine, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Antimicrob Agents Chemother 51:1671-7. 2007
    ..b>Coagulase-negative staphylococci (CoNS) contained several representatives of different ccr complexes and thus seemed to ..
  31. ncbi Identification and characterization of methicillin-resistant coagulase-negative staphylococci from bovine mastitis
    Andrea T Fessler
    Institute of Farm Animal Genetics, Friedrich Loeffler Institut FLI, Neustadt Mariensee, Germany
    J Antimicrob Chemother 65:1576-82. 2010
    ..focused on the correlation between geno- and phenotypic tests in the correct assessment of mecA-mediated methicillin resistance among coagulase-negative staphylococci (CoNS) and the further characterization of mecA-positive isolates.
  32. pmc Comparison of genotypic and phenotypic methods for species-level identification of clinical isolates of coagulase-negative staphylococci
    E Heikens
    Eijkman Winkler Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    J Clin Microbiol 43:2286-90. 2005
    To compare commonly used phenotypic methods with genotypic identification methods 47 clinical isolates of coagulase-negative staphylococci (CONS), 10 CONS ATCC strains, and a Staphylococcus aureus clinical isolate were identified using ..
  33. pmc Key role for clumping factor B in Staphylococcus aureus nasal colonization of humans
    Heiman F L Wertheim
    Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    PLoS Med 5:e17. 2008
    ..aureus colonizes the nose are still unknown. The staphylococcal cell-wall protein clumping factor B (ClfB) promotes adhesion to squamous epithelial cells in vitro and might be a physiologically relevant colonization factor...
  34. pmc Structural and biochemical characterization of Staphylococcus aureus clumping factor B/ligand interactions
    Vannakambadi K Ganesh
    Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 286:25963-72. 2011
    ..A common motif GSSGXG found in both ligands is part of the ClfB-binding site. This motif is found in many human proteins thus raising the possibility that ClfB recognizes additional ligands...
  35. pmc A play in four acts: Staphylococcus aureus abscess formation
    Alice G Cheng
    Department of Microbiology, University of Chicago, Chicago, Illinois 60637, USA
    Trends Microbiol 19:225-32. 2011
    ..Protein A and coagulases are distinctive virulence attributes for S. aureus, and humoral immune responses specific for these polypeptides provide protection against abscess formation in animal models of staphylococcal disease...
  36. pmc Signal peptides direct surface proteins to two distinct envelope locations of Staphylococcus aureus
    Andrea DeDent
    Department of Microbiology, University of Chicago, Chicago, IL 60637, USA
    EMBO J 27:2656-68. 2008
    ....
  37. ncbi Coagulase-negative staphylococci-emerging mastitis pathogens
    Satu Pyörälä
    University of Helsinki, Department of Production Animal Medicine, FI 04920 Saarentaus, Finland
    Vet Microbiol 134:3-8. 2009
    b>Coagulase-negative staphylococci (CNS) have become the most common bovine mastitis isolate in many countries and could therefore be described as emerging mastitis pathogens...
  38. pmc Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci
    K R Fiebelkorn
    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas 78229 3750, USA
    J Clin Microbiol 41:4740-4. 2003
    ..A group of 130 clinical isolates of Staphylococcus aureus and 100 isolates of erythromycin-resistant coagulase-negative staphylococci (CNS) were examined by disk approximation; all CNS isolates and a subset of S...
  39. pmc Reassessing the role of Staphylococcus aureus clumping factor and fibronectin-binding protein by expression in Lactococcus lactis
    Y A Que
    Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Infect Immun 69:6296-302. 2001
    ..Taken together, the present observations suggest that if antiadhesin therapy were to be developed, at least both of the clfA and fnbA products should be blocked for the therapy to be effective...
  40. ncbi Pathogenesis of infections due to coagulase-negative staphylococci
    Christof von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Munster, Germany
    Lancet Infect Dis 2:677-85. 2002
    As a group, the coagulase-negative staphylococci (CoNS) are among the most frequently isolated bacteria in the clinical microbiology laboratory and are becoming increasingly important, especially as causes of hospital-acquired infections...
  41. ncbi Coagulase-negative staphylococcal sepsis in neonates. Association between antibiotic resistance, biofilm formation and the host inflammatory response
    Claus Klingenberg
    Department of Pediatrics, University Hospital of North Norway
    Pediatr Infect Dis J 24:817-22. 2005
    b>Coagulase-negative staphylococci (CoNS) are the most prevalent pathogens causing late onset sepsis in neonates. They are often multiresistant to antibiotics, and the ability to form biofilm is considered their main virulence determinant.
  42. pmc Local variants of Staphylococcal cassette chromosome mec in sporadic methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococci: evidence of horizontal gene transfer?
    Anne Merethe Hanssen
    Department of Microbiology and Virology, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Antimicrob Agents Chemother 48:285-96. 2004
    ..Clinical isolates of coagulase-negative staphylococci (CoNS; n = 39) and S...
  43. pmc Characterization of methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus spp. isolated from US West Coast public marine beaches
    Olusegun O Soge
    Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA
    J Antimicrob Chemother 64:1148-55. 2009
    ..was to isolate and characterize methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus spp...
  44. ncbi Persistent strains of coagulase-negative staphylococci in a neonatal intensive care unit: virulence factors and invasiveness
    C Klingenberg
    Department of Paediatrics, University Hospital of North Norway, Tromsø, Norway
    Clin Microbiol Infect 13:1100-11. 2007
    b>Coagulase-negative staphylococci (CoNS) are the major cause of nosocomial bacteraemia in neonates...
  45. ncbi Staphylococcus pseudintermedius sp. nov., a coagulase-positive species from animals
    Luc A Devriese
    Department of Pathology, Bacteriology and Poultry Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Int J Syst Evol Microbiol 55:1569-73. 2005
    ..were isolated from lesions and show several characteristics typical of pathogenic staphylococci, such as coagulase, DNase and beta-haemolysin production, the pathogenic significance of the novel species remains unclear...
  46. ncbi Characterization of toxin production of coagulase-negative staphylococci isolated from food and starter cultures
    Christiane Zell
    Institute of Microbial Genetics, University of Tubingen, Tubingen, Germany
    Int J Food Microbiol 127:246-51. 2008
    In this study a comprehensive analysis of toxin production of food associated coagulase-negative staphylococci (CNS) was investigated...
  47. ncbi Antimicrobial susceptibility of coagulase-negative staphylococci isolated from bovine milk samples
    O C Sampimon
    GD Animal Health Service, Arnsbergstraat 7, P O Box 9, 7400 AA Deventer, The Netherlands
    Vet Microbiol 150:173-9. 2011
    The aim of this study was to examine whether antimicrobial resistance profiles of coagulase-negative Staphylococcus (CNS) species isolated from milk of dairy cows differed between bacterial species, and to compare results obtained by ..
  48. ncbi Antibiotic resistance and molecular characterization of clinical isolates of methicillin-resistant coagulase-negative staphylococci isolated from bacteremic patients in oncohematology
    O Bouchami
    Laboratory Department, Centre National de Greffe de Moelle Osseuse, Tunis, Tunisia
    Folia Microbiol (Praha) 56:122-30. 2011
    ..PFGE) of SmaI macrorestriction fragments of genomic DNA were used to characterize 45 methicillin-resistant coagulase-negative staphylococci (MRCoNS) isolates responsible of bacteremia recovered in patients at the Bone Marrow ..
  49. pmc Cfr-mediated linezolid-resistance among methicillin-resistant coagulase-negative staphylococci from infections of humans
    Lanqing Cui
    Institute of Clinical Pharmacology, Peking University First Hospital, Peking University, Beijing, People s Republic of China
    PLoS ONE 8:e57096. 2013
    Four methicillin-resistant coagulase-negative staphylococci (MRCoNS), one Staphylococcus haemolyticus and three Staphylococcus cohnii, from infections of humans collected via the Ministry of Health National Antimicrobial Resistance ..
  50. ncbi Evaluation and treatment of neonates with suspected late-onset sepsis: a survey of neonatologists' practices
    Lorry G Rubin
    Department of Pediatrics, Schneider Children s Hospital of the North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
    Pediatrics 110:e42. 2002
    ..To ascertain current diagnostic and treatment practices for suspected late-onset sepsis in infants in neonatal intensive care units (NICUs) and identify areas that may benefit from clinical practice guidelines...
  51. ncbi Emergence of coagulase-negative staphylococci as a cause of native valve endocarditis
    Vivian H Chu
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Infect Dis 46:232-42. 2008
    b>Coagulase-negative staphylococci (CoNS) are an infrequent cause of native valve endocarditis (NVE), and our understanding of NVE caused by CoNS is incomplete.
  52. pmc Two distinct coagulase-dependent barriers protect Staphylococcus aureus from neutrophils in a three dimensional in vitro infection model
    Christoph Guggenberger
    Max von Pettenkofer Institut, Ludwig Maximilians University of Munich LMU, Munich, Germany
    PLoS Pathog 8:e1002434. 2012
    ..g. fibrinogen binding proteins Eap and Emp) and prothrombin activators such as Coagulase (Coa) and vWbp are involved in abscess formation...
  53. pmc Coagulase-negative staphylococcal infections in the neonatal intensive care unit
    Naomi Jean-Baptiste
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Infect Control Hosp Epidemiol 32:679-86. 2011
    b>Coagulase-negative staphylococci (CoNS) are the most commonly isolated pathogens in the neonatal intensive care unit (NICU). CoNS infections are associated with increased morbidity, including neurodevelopmental impairment.
  54. ncbi Coagulase-negative staphylococci: clinical, microbiological and molecular features to predict true bacteraemia
    Patricia Garcia
    Unidad Docente Asociada de Laboratorios Clínicos, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
    J Med Microbiol 53:67-72. 2004
    b>Coagulase-negative staphylococci (CNS) are frequently isolated from blood cultures, where they may be only a contaminant or the cause of bacteraemia...
  55. ncbi Staphylococcal colonization of mucosal and lesional skin sites in atopic and healthy dogs
    Jennifer Fazakerley
    Department of Veterinary Clinical Science, The University of Liverpool, Faculty of Veterinary Science, Liverpool, UK
    Vet Dermatol 20:179-84. 2009
    ..b>Coagulase positive staphylococcal isolates were identified to the species level...
  56. ncbi Glycopeptide resistance in coagulase-negative staphylococci isolated in blood cultures from patients with hematological malignancies during three decades
    E Ahlstrand
    Department of Medicine, Division of Hematology, Orebro University Hospital, 701 85 Orebro, Sweden
    Eur J Clin Microbiol Infect Dis 30:1349-54. 2011
    ..The presence of heterogeneously glycopeptide-intermediate staphylococci (hGIS) was analyzed among 405 coagulase-negative staphylococci (CoNS) isolates...
  57. ncbi Molecular epidemiology of coagulase-negative staphylococcal bacteraemia in a newborn intensive care unit
    O Raimundo
    Department of Biotechnology and Environmental Biology, Royal Melbourne Institute of Technology, Melbourne, Australia
    J Hosp Infect 51:33-42. 2002
    We isolated 55 coagulase-negative staphylococci (CoNS) over two separate 12-month periods (26 in 1993 and 29 in 1996) from the blood of neonates in a neonatal intensive case unit (NICU) in Melbourne, Australia and compared them by pulse-..
  58. ncbi Coagulase negative staphylococci and their participation in pathogenesis of human infections
    A Longauerova
    Institute of Microbiology, Faculty ofMedicine, University Hospital, Comenius University, Bratislava, Slovakia
    Bratisl Lek Listy 107:448-52. 2006
    b>Coagulase negative staphylococci are among the bacteria routinely isolated at various clinical microbiology departments. There are presently 41 recognized taxons, designated coagulase negative staphylococci...
  59. ncbi Sepsis due to linezolid resistant Staphylococcus cohnii and Staphylococcus kloosii: first reports of linezolid resistance in coagulase negative staphylococci from India
    M A Peer
    Department of Clinical Microbiology, Sher I Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India
    Indian J Med Microbiol 29:60-2. 2011
    ..Herein, we report two cases of linezolid resistant, coagulase negative staphylococcal sepsis for the first time from India...
  60. ncbi Coagulase-negative staphylococcal sepsis as a predictor of bronchopulmonary dysplasia
    Magnus Liljedahl
    Department of Paediatrics, Orebro University Hospital, SE 70185 Orebro, Sweden
    Acta Paediatr 93:211-5. 2004
    To determine whether sepsis caused by coagulase-negative staphylococci (CoNS) is a risk factor for developing bronchopulmonary dysplasia (BPD) in premature newborns.
  61. pmc Effects of subinhibitory concentrations of vancomycin or cefamandole on biofilm production by coagulase-negative staphylococci
    W M Dunne
    Department of Pathology, Children s Hospital of Wisconsin, Milwaukee
    Antimicrob Agents Chemother 34:390-3. 1990
    ..biofilm layer produced on a plastic surface by 23 clinical isolates and 1 reference strain of slime-positive, coagulase-negative staphylococci was measured following growth in subinhibitory concentrations (sub-MICs) of cefamandole ..
  62. ncbi Central venous catheter removal versus in situ treatment in neonates with coagulase-negative staphylococcal bacteremia
    M Gary Karlowicz
    Department of Pediatrics, Eastern Virginia Medical School, Children s Hospital of the King s Daughters, Norfolk, VA 23507, USA
    Pediatr Infect Dis J 21:22-7. 2002
    To determine how often neonates with coagulase-negative staphylococcal (CONS) bacteremia can be treated successfully without removing the central venous catheter (CVC).
  63. pmc Molecular epidemiology of coagulase-negative staphylococci causing sepsis in a neonatal intensive care unit over an 11-year period
    Tannette G Krediet
    Department of Neonatology, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    J Clin Microbiol 42:992-5. 2004
    b>Coagulase-negative staphylococci (CoNS) are the major causative microorganisms in neonatal nosocomial sepsis...
  64. ncbi Epidemiology of drug resistance: the case of Staphylococcus aureus and coagulase-negative staphylococci infections
    Ernesto Calderon-Jaimes
    Departamento de Inmunoquímica y Biología Celular, Hospital Infantil de Mexico Federico Gomez, Dr Márquez No 162, Colonia Doctores, 06720 Mexico, D F, Mexico
    Salud Publica Mex 44:108-12. 2002
    ..To study the activity of several antibiotics against Staphylococcus spp...
  65. ncbi Polymerase chain reaction detection of enterotoxins genes in coagulase-negative staphylococci isolated from Brazilian Minas cheese
    Vera Lucia Mores Rall
    Department of Microbiology and Immunology, Institute of Biosciences, Sao Paulo State University UNESP, Botucatu, Sao Paulo, Brazil
    Foodborne Pathog Dis 7:1121-3. 2010
    ..Staphylococcus aureus has been always thought to be the only pathogenic species among Staphylococcus, while coagulase-negative staphylococci (CNS) were classified as contaminant agents...
  66. ncbi Screening for skin carriage of methicillin-resistant coagulase-positive staphylococci and Staphylococcus schleiferi in dogs with healthy and inflamed skin
    Gregory C Griffeth
    Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA
    Vet Dermatol 19:142-9. 2008
    ..skin disease to determine prevalence of carriage and relative frequency of methicillin resistance in coagulase-positive staphylococci and S. schleiferi ssp. schleiferi...
  67. pmc Rapid and accurate species-level identification of coagulase-negative staphylococci by using the sodA gene as a target
    C Poyart
    Laboratoire Mixte Pasteur Necker de Recherche sur les Streptocoques et Streptococcies and Unité INSERM 411, Faculte de Medecine Necker Enfants Malades, Paris, France
    J Clin Microbiol 39:4296-301. 2001
    ..DNA fragment internal (sodA(int)) to the sodA gene encoding the manganese-dependent superoxide dismutase in 40 coagulase-negative staphylococcal (CNS) type strains...
  68. ncbi Non- epidermidis coagulase-negative staphylococcal bacteremia: clinical predictors of true bacteremia
    J Ruhe
    Department of Medicine, Infectious Diseases Section, Tulane University School of Medicine, 1430 Tulane Avenue SL 87, New Orleans, LA 70112, USA
    Eur J Clin Microbiol Infect Dis 23:495-8. 2004
    In order to explore the clinical significance and risk factors for true bacteremia caused by coagulase-negative staphylococci (CNS) other than Staphylococcus epidermidis, a retrospective cohort study of 160 patients with at least one ..
  69. ncbi Defective neutrophil oxidative burst in preterm newborns on exposure to coagulase-negative staphylococci
    Maria Björkqvist
    Department of Pediatrics, Orebro University Hospital, S 701 85 Orebro, Sweden
    Pediatr Res 55:966-71. 2004
    ..oxidative burst in term (n = 10) and preterm newborns <31 wk gestational age (n = 10) after stimulation with coagulase-negative staphylococci in vitro...
  70. ncbi Comparing clinical and microbiological methods for the diagnosis of true bacteraemia among patients with multiple blood cultures positive for coagulase-negative staphylococci
    I Al Wohoush
    Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Clin Microbiol Infect 17:569-71. 2011
    ..Control and Prevention (CDC) clinical criteria as well as other microbiological methods for the diagnosis of coagulase-negative staphylococci bacteraemia...
  71. ncbi Antibiotic resistance of coagulase-negative staphylococci associated with food and used in starter cultures
    Marion Resch
    University of Hohenheim, Institute of Food Science and Biotechnology, Section Food Microbiology, Garbenstrasse 28, D 70599 Stuttgart, Germany
    Int J Food Microbiol 127:99-104. 2008
    The resistance of 330 coagulase-negative staphylococci (CNS) associated with food or used in starter cultures and belonging to the species Staphylococcus carnosus, Staphylococcus condimenti, Staphylococcus piscifermentans, Staphylococcus ..
  72. pmc Coagulase positive staphylococcal colonization of humans and their household pets
    Beth A Hanselman
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1
    Can Vet J 50:954-8. 2009
    ..Indistinguishable canine and human S. pseudintermedius isolates were present in 4/9 of households with a human who was colonized...
  73. ncbi Antibiotic resistance patterns of coagulase-negative staphylococcus strains isolated from blood cultures of septicemic patients in Turkey
    F Koksal
    Department of Microbiology and Clinical Microbiology, Istanbul University Cerrahpasa Medical Faculty, 34098 Cerrahpasa, Istanbul, Turkey
    Microbiol Res 164:404-10. 2009
    The aim of this study is to determine antibiotic resistance patterns and slime production characteristics of coagulase-negative Staphylococci (CoNS) caused nosocomial bacteremia...
  74. ncbi Antimicrobial resistance and production of biofilms in clinical isolates of coagulase-negative Staphylococcus strains
    María Cristina Gaudioso de Allori
    Cátedra de Bacteriología, Instituto de Microbiología Luis C Verna, Facultad de Bioquimica, Química, Farmacia y Biotecnología, Universidad Nacional de Tucuman, Argentina
    Biol Pharm Bull 29:1592-6. 2006
    b>Coagulase-negative Staphylococcus (CNS) strains are frequently associated with bacteremia and hospital-acquired infections. 293 CNS strains were isolated from 744 samples from a dialysis center in S. M...
  75. ncbi Isolation of methicillin-resistant coagulase-negative staphylococci from patients undergoing continuous ambulatory peritoneal dialysis (CAPD) and comparison of different molecular techniques for discriminating isolates of Staphylococcus epidermidis
    Elaine Marques de Mattos
    Laboratorio de Biologia Molecular de Bacterias, Instituto de Microbiologia Prof Paulo de Goes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Diagn Microbiol Infect Dis 45:13-22. 2003
    b>Coagulase-negative staphylococci (CNS) have emerged as an important pathogen in nosocomial infections. About 80%-90% of CNS isolates associated with hospital infections are methicillin-resistant coagulase-negative staphylococci (MRCNS)...
  76. ncbi The sae locus of Staphylococcus aureus controls exoprotein synthesis at the transcriptional level
    A T Giraudo
    Departamento de Microbiologia, Facultad de Ciencias Exactas, Fisico Quimicas y Naturales, Universidad Nacional Río Cuarto, Ruta 36 Km 601, 5800 Rio Cuarto, Cordoba, Argentina
    Arch Microbiol 168:53-8. 1997
    ..designated sae, that leads to the production of drastically diminished levels of alpha- and beta-hemolysins and coagulase and slightly reduced levels of protein A has been described...
  77. ncbi Organ- and host-specific clonal groups of Staphylococcus aureus from human infections and bovine mastitis revealed by the clumping factor A gene
    Kamaleldin B Said
    Department of Animal Science, McGill University, Quebec, Canada
    Foodborne Pathog Dis 7:111-9. 2010
    ..Thus, clfA is useful in detecting the clonal lineage of mastitis, and tracing and grouping organ-specific strains, and might be a potential tool for studying host specialization and selection...
  78. ncbi Low occurrence of safety hazards in coagulase negative staphylococci isolated from fermented foodstuffs
    Sergine Even
    INRA, UMR1253 STLO, 85 rue de Saint Brieuc, F 35042 Rennes, France
    Int J Food Microbiol 139:87-95. 2010
    Some coagulase negative staphylococci (CNS) species play an important role in the fermentation of meat and milk products and are considered as food-grade...
  79. ncbi Comparative subproteome analyses of planktonic and sessile Staphylococcus xylosus C2a: new insight in cell physiology of a coagulase-negative Staphylococcus in biofilm
    Stella Planchon
    INRA, UR454 Microbiologie, F 63122 Saint Genes Champanelle, France
    J Proteome Res 8:1797-809. 2009
    ..To gain further insight in protein determinants involved in biofilm formation by this coagulase-negative Staphylococcus, a comparative proteomic analysis between planktonic and sessile cells was performed...
  80. ncbi Repeat-based subtyping and grouping of Staphylococcus aureus from human infections and bovine mastitis using the R-domain of the clumping factor A gene
    Kamaleldin B Said
    Department of Animal Science, McGill University, Ste Anne de Bellevue, Quebec H9X 3V9, Canada
    Diagn Microbiol Infect Dis 63:24-37. 2009
    ..Moreover, existence of variant repeats in human strains and the dominance of a clonal motif in mastitis may imply that a specific selection has occurred in the mammary gland...
  81. ncbi Interaction of coagulase-negative Staphylococcus species with bovine mammary epithelial cells
    R A Almeida
    Food Safety Center of Excellence, Department of Animal Science, Knoxville, TN 37996
    Microb Pathog 31:205-12. 2001
    Three coagulase-negative Staphylococcus species (CNS) (Staphylococcus epidermidis, Staphylococcus xylosus and Staphylococcus hyicus), from the milk of cows with mastitis, were used to evaluate adherence to and internalization by bovine ..
  82. ncbi Argatroban inhibits staphylothrombin
    A Hijikata-Okunomiya
    J Thromb Haemost 1:2060-1. 2003
  83. ncbi Pharmacodynamic comparison of linezolid, teicoplanin and vancomycin against clinical isolates of Staphylococcus aureus and coagulase-negative staphylococci collected from hospitals in Brazil
    J L Kuti
    Center for Anti Infective Research and Development, Hartford Hospital, CT, USA
    Clin Microbiol Infect 14:116-23. 2008
    ..5000-patient Monte-Carlo simulation against 119 non-duplicate clinical isolates of Staphylococcus aureus and 82 coagulase-negative staphylococci (CNS) collected from hospitals in Brazil between 2003 and 2005...
  84. ncbi Identification of clinical coagulase-negative staphylococci, isolated in microbiology laboratories, by matrix-assisted laser desorption/ionization-time of flight mass spectrometry and two automated systems
    C Dupont
    Hopital Raymond Poincare, Garches, France
    Clin Microbiol Infect 16:998-1004. 2010
    ..Becton Dickinson Diagnostic Systems, France) and VITEK-2 (bioMérieux, Marcy L'Etoile, France), for the ID of coagulase-negative staphylococci (CoNS)...
  85. pmc Simultaneous detection of Staphylococcus aureus and coagulase-negative staphylococci in positive blood cultures by real-time PCR with two fluorescence resonance energy transfer probe sets
    H Sakai
    Department of Anatomic Pathology, Section of Surgical Pathology, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    J Clin Microbiol 42:5739-44. 2004
    ..This assay was 100% sensitive and 100% specific for the detection of the Staphylococcus genus and of S. aureus...
  86. pmc A ten year, multicentre study of coagulase negative staphylococcal infections in Australasian neonatal units
    D Isaacs
    Department of Immunology and Infectious Diseases, Children s Hospital Westmead, Westmead, NSW 2145, Australia
    Arch Dis Child Fetal Neonatal Ed 88:F89-93. 2003
    To study late onset systemic infections with coagulase negative staphylococci.
  87. ncbi Prevalence and herd-level risk factors for intramammary infection with coagulase-negative staphylococci in Dutch dairy herds
    O C Sampimon
    GD Animal Health Service, Deventer, The Netherlands
    Vet Microbiol 134:37-44. 2009
    In this study, the prevalence of intramammary infection (IMI) with coagulase-negative staphylococci (CNS) in The Netherlands was estimated on 49 randomly selected herds with at least 40 lactating cows...
  88. ncbi Bovine intramammary infections caused by coagulase-negative staphylococci may persist throughout lactation according to amplified fragment length polymorphism-based analysis
    S Taponen
    Department of Production Animal Medicine, University of Helsinki, 00014 Helsinki, Finland
    J Dairy Sci 90:3301-7. 2007
    Persistence of coagulase-negative staphylococci (CNS) in intramammary infections during lactation was studied in a research dairy herd of University of Helsinki...
  89. ncbi Prevalence and persistence of coagulase-negative Staphylococcus species in three dairy research herds
    B E Gillespie
    Department of Animal Science, The University of Tennessee, Knoxville, TN 37996, USA
    Vet Microbiol 134:65-72. 2009
    b>Coagulase-negative Staphylococcus species (CNS) were isolated from 11.3% (1407 of 12,412) of mammary quarter milk samples obtained from cows in three dairy research herds in 2005...
  90. ncbi Coagulase-negative staphylococci isolated from bovine extramammary sites and intramammary infections in a single dairy herd
    Suvi Taponen
    University of Helsinki, Faculty of Veterinary Medicine, Department of Production Animal Medicine, Finland
    J Dairy Res 75:422-9. 2008
    Isolates of various species of coagulase-negative staphylococci (CNS) from extramammary swab samples were compared with isolates of bovine mastitis CNS species...
  91. ncbi Clinical characteristics and persistence of bovine mastitis caused by different species of coagulase-negative staphylococci identified with API or AFLP
    Suvi Taponen
    University of Helsinki, Faculty of Veterinary Medicine, Department of Clinical Veterinary Sciences, Finland
    Vet Microbiol 115:199-207. 2006
    The coagulase-negative staphylococcal species causing mastitis in lactating cattle were identified and possible differences in the clinical characteristics or persistence of mastitis caused by different CNS were evaluated...
  92. pmc Identification of Staphylococcus aureus: DNase and Mannitol salt agar improve the efficiency of the tube coagulase test
    David P Kateete
    Department of Medical Microbiology, School of Biomedical Sciences, Makerere University College of Health Sciences, Upper Mulago hill road, Kampala, Uganda
    Ann Clin Microbiol Antimicrob 9:23. 2010
    ..In many developing countries, the tube coagulase test is usually confirmatory for S. aureus and is routinely done using either human or sheep plasma...
  93. ncbi Diversity of staphylococcal cassette chromosome in coagulase-negative staphylococci from animal sources
    Y Zhang
    Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, USA
    J Appl Microbiol 107:1375-83. 2009
    To type the staphylococcal cassette chromosome (SCC) in coagulase-negative staphylococci (CoNS) from animal sources.
  94. ncbi Species identification of staphylococci by amplification and sequencing of the tuf gene compared to the gap gene and by matrix-assisted laser desorption ionization time-of-flight mass spectrometry
    M Bergeron
    Laboratoire de Bacteriologie, Centre de biologie et pathologie est, Hospices Civils de Lyon, Bron, France
    Eur J Clin Microbiol Infect Dis 30:343-54. 2011
    Staphylococcal species, notably, coagulase-negative staphylococci (CoNS), are frequently misidentified using phenotypic methods...
  95. ncbi Mucosa or skin as source of coagulase-negative staphylococcal bacteraemia?
    Silvia F Costa
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    Lancet Infect Dis 4:278-86. 2004
    ..is associated with significant morbidity, mortality, and cost worldwide, and is most commonly caused by coagulase-negative staphylococci (CONS)...
  96. ncbi Coagulase-negative staphylococci. Pathogens have major role in nosocomial infections
    C von Eiff
    Institute of Medical Microbiology, University of Münster Hospital and Clinics, Domagkstrasse 10, 48149 Munster, Germany
    Postgrad Med 110:63-4, 69-70, 73-6. 2001
    b>Coagulase-negative staphylococci live naturally on the skin and mucous membranes of humans and are therefore often found in clinical specimens...
  97. pmc The ica operon and biofilm production in coagulase-negative Staphylococci associated with carriage and disease in a neonatal intensive care unit
    G D I de Silva
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 40:382-8. 2002
    b>Coagulase-negative staphylococci (CoNS) are a major cause of sepsis in the neonatal intensive care unit (NICU). We evaluated the hypothesis that the ica operon and biofilm production are associated with CoNS disease in this setting...
  98. ncbi Serum procalcitonin for discrimination of blood contamination from bloodstream infection due to coagulase-negative staphylococci
    P Schuetz
    Dept of Internal Medicine, University Hospital Basel, Petersgraben 4, Basel, 4031, BS, Switzerland
    Infection 35:352-5. 2007
    ..value of serum procalcitonin (PCT) to distinguish blood contamination from bloodstream infection (BSI) due to coagulase-negative staphylococci was evaluated...
  99. ncbi Coagulase-negative staphylococcal infections in the neonate and child: an update
    Mohan P Venkatesh
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2300, USA
    Semin Pediatr Infect Dis 17:120-7. 2006
    b>Coagulase-negative staphylococcus (CONS) infection is the most common bloodstream infection treated in neonatal and pediatric intensive care units and significantly impacts patient mortality and morbidity...
  100. ncbi Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation
    Rainer Friedrich
    Abteilung Strukturforschung, Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    Nature 425:535-9. 2003
    ..These investigations demonstrate unambiguously the validity of the zymogen-activation mechanism known as 'molecular sexuality'...
  101. ncbi The antibacterial activity of honey against coagulase-negative staphylococci
    V M French
    Honey Research Unit, Department of Biological Sciences University of Waikato, Hamilton, New Zealand
    J Antimicrob Chemother 56:228-31. 2005
    Development of antibiotic-resistant strains of coagulase-negative staphylococci has complicated the management of infections associated with the use of invasive medical devices, and innovative treatment and prophylactic options are ..

Research Grants32

  1. Prevention and therapy of Staphylococcus aureus infections
    Olaf Schneewind; Fiscal Year: 2010
    ..During staphylococcal infection, protein A, coagulase and von-Willebrand-Factor binding-protein impart toxic functions on blood clotting or immune suppression that ..
  2. Hemostatic-antibiotic Combination for Prevention of MRSA Surgical Site Infections
    Timothy C Fisher; Fiscal Year: 2010
    ..Aureus and coagulase-negative Staph species...
  3. The Role of Lactate in the ???Metabolic Evolution??? of Staphylococcus aureus
    Anthony R Richardson; Fiscal Year: 2013
    ..NO.-resistance is not apparent in other bacteria, including closely related coagulase negative staphylococci (CNS). We have found that the key to S. aureus NO...
  4. POINT OF CARE DIAGNOSTICS FOR URINARY TRACT INFECTION
    KUMAR SUBRAMANIAN; Fiscal Year: 2012
    ..coli, and coagulase negative Staphylococcus...
  5. Pathobiology of Staphyloccocus areus Endocarditis
    PETER ROLF PANIZZI; Fiscal Year: 2010
    ..b>Coagulase-positive S...
  6. Pathobiology of Staphyloccocus areus Endocarditis
    PETER ROLF PANIZZI; Fiscal Year: 2013
    ..b>Coagulase-positive S...
  7. Hemostatic Factors as Determinants of Bacterial Virulence and Host Defense.
    Jay L Degen; Fiscal Year: 2010
    ..genetic changes in prothrombin, plasminogen and their respective microbial-derived activators: coagulase and staphylokinase (Aim 2 and 3)...
  8. 2011 Staphyloccocal Diseases Gordon Research Conference
    Vance G Fowler; Fiscal Year: 2011
    ..aureus and coagulase-negative staphylococci...
  9. Population Genomics of Staphylococci
    Ashley Robinson; Fiscal Year: 2013
    ..Staphylococcus epidermidis and other coagulase-negative staphylococci, once exclusively considered to be commensal species, have emerged as a leading cause of ..
  10. Multi-componet Vaccine for Staphylcoccus epidermidis
    Tomas Maira Litran; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Coagulase-negative staphylococci (CoNS), notably Staphylococcus epidermidis, are a predominant cause of hospital-acquired infections and treatment can be difficult owing to biofilm formation and ..
  11. GENOME ANALYSIS OF STAPHYLOCOCCUS EPIDERMIDIS
    Steven Gill; Fiscal Year: 2001
    The goal of this project is to determine the complete genome sequence of Staphylococcus epidermidis, a coagulase negative staphylococci (CoNS) which is an emerging pathogen of increasing clinical significance. Of the CoNS group, S...
  12. ELECTRON TRANSPORT VARIANTS IN STAPHYLOCOCCAL DISEASE
    Richard Proctor; Fiscal Year: 2001
    ..24-48 hrs on solid medium and overgrown in liquid medium) and misidentify ETVs because they are atypical (slowly coagulase positive, non-hemolytic, mannitol negative, non-pigmented)...
  13. ADHESINS OF COAGULASE NEGATIVE STAPHYLOCOCCI
    Gerald Pier; Fiscal Year: 1999
    ..application's long- term specific aims are to elucidate mechanisms whereby Staphylococcus epidermidis and other coagulase-negative staphylococci (CoNS) have become one of the most important nosocomial pathogens during the past decade...
  14. GORDON CONFERENCE ON STAPHYLOCOCCAL DISEASES
    Henry Chambers; Fiscal Year: 1999
    ..There will be nine scientific sessions held over five days on biology of both Staphylococcus aureus and coagulase-negative staphylococci with topics including virulence and virulence factors, animal models of staphylococcal ..
  15. GLYCOPEPTIDE RESISTANCE LOCI IN STAPHYLOCOCCUS AUREUS
    Susan Boyle Vavra; Fiscal Year: 2001
    ..GP resistance has been recognized among the less-pathogenic coagulase-negative staphylococcal species for many years...
  16. Imaging Endocarditis
    Peter Panizzi; Fiscal Year: 2009
    ..The leading cause of deaths from ABE is associated with coagulase-positive Staphylococcus aureus infections which account for 40-50% of neonatal endocarditis and 30-40% of ..
  17. STAPHYLOCOCCAL METHICILLIN RESISTANCE LOCUS
    Gordon Archer; Fiscal Year: 2003
    ..The total extent and composition of mec DNA will also be determined among MR S. aureus and coagulase-negative staphylococci by cloning large, overlapping DNA fragments and DNA sequencing and PCR amplification, ..
  18. ACTIVE & PASSIVE IMMUNIZATION FOR STAPHYLOCOCCAL DISEASE
    Subramonia Pillai; Fiscal Year: 2000
    ..and recombinant human monoclonal antibodies effective against diseases caused by Staphylococcus aureus and coagulase negative staphylococci (CoNS, mostly S. epidermidis). S...
  19. Novel Biosensor for Detecting Antibiotic Resistance
    Jean Clarke; Fiscal Year: 2006
    ..concentrations of biological analytes, in this case, MRSA mecA gene (for resistance identification), coa gene (coagulase, for species identification), and PBP2a protein (penicillin binding protein 2a, for resistance identification)...
  20. STAPHYLOCOCCUS AND METHICILLIN RESISTANCE ASSAY
    JAMES STORHOFF; Fiscal Year: 2001
    ..the proposed research is to develop a rapid, simultaneous assay permitting determination of mecA gene carriage, coagulase gene presence, and multiple 16S ribosomal RNA gene sequences...
  21. Gordon Research Conference on Staphylococcal Diseases
    Henry Chambers; Fiscal Year: 2001
    ..The emphasis of this conference is on the biology of Staphylococcus aureus and coagulase-negative staphylococci; pathogenesis of diseases caused by staphylococci; and recent advances in basic, applied, ..
  22. GORDON CONFERENCE ON STAPHYLOCOCCAL DISEASE
    George Stewart; Fiscal Year: 1991
    ..the human major histocompatibility complex, their pathophysiology, and regulation of their genes), surface properties of coagulase negative staphylococci, and molecular epidemiology (DNA probes, DNA fingerprinting of clinical isolates).
  23. Ligand-Receptor Segregation and Airway Remodeling
    Joseph Zabner; Fiscal Year: 2007
    ..We hypothesize that in the asthmatic airways, alterations in the epithelial barrier play a central role in airway epithelial remodeling. ..
  24. Innate Effectors of rAls3p-N Anti-Candida Vaccine
    Brad J Spellberg; Fiscal Year: 2010
    ..PNS 398/2590 (Rev. 11/07) Page - Continuation Format Page ..
  25. Novel antibacterial agents for treatment of Tularemia
    Nachum Kaplan; Fiscal Year: 2004
    ..tularensis microbiological data and animal model data to warrant inclusion of the information on the product label as a narrow spectrum agent that could be used in the event of a F. tularensis release. ..
  26. Triple action chimera: eradication of nasal S. aureus by cell wall hydrolases
    DAVID MATTHEW DONOVAN; Fiscal Year: 2010
    ..This study will explore a novel antimicrobial agent (a triple action chimeric viral enzyme) to eradicate S. aureus nasal colonization, since nasal carriage is a known risk factor for infection. ..
  27. CARDIOTOXICITY OF STREPTOCOCCAL PYROGENIC EXOTOXINS
    Patrick Schlievert; Fiscal Year: 2006
    ....
  28. Spread of Community-Acquired MRSA Among Household Contacts
    Robert S Daum; Fiscal Year: 2010
    ....
  29. MECHANISMS OF GLYCOPEPTIDE RESISTANCE IN STAPHYLOCOCCI
    Robert Daum; Fiscal Year: 2006
    ..cell wall reorganization; pleiotropic changes have been documented such as altered peptidoglycan structure, coagulase activity, binding of vancomycin, autolytic activity and lysostaphin susceptibility...
  30. MRSA Colonization and Control in the Cook County Jail - R01
    Robert Daum; Fiscal Year: 2008
    ..We hope that the Cook County jail will become a model jail for the control of MRSA and other resistant bacteria. [unreadable] [unreadable] [unreadable]..
  31. Transmission Dynamics of Antimocrobial-resistant bacteria in dialysis units
    ERIKA D AGATA; Fiscal Year: 2007
    ..Limiting ARB spread will ultimately reduce infections caused by ARB and improve CHD patient outcomes. [unreadable] [unreadable] [unreadable]..
  32. Adrenergic Antagonism During Murine Candidiasis
    Brad Spellberg; Fiscal Year: 2008
    ..For these reasons, the potential for adrenergic antagonism to act as an effective immunotherapy is highly meritorious of investigation in this training application. ..