bacteriocins

Summary

Summary: Substances elaborated by specific strains of bacteria that are lethal against other strains of the same or related species. They are protein or lipopolysaccharide-protein complexes used in taxonomy studies of bacteria.

Top Publications

  1. ncbi Bacteriocins: developing innate immunity for food
    Paul D Cotter
    Alimentary Pharmabiotic Centre, Microbiology Department, University College Cork, Cork, Ireland
    Nat Rev Microbiol 3:777-88. 2005
  2. ncbi Bacteriocins - a viable alternative to antibiotics?
    Paul D Cotter
    Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland
    Nat Rev Microbiol 11:95-105. 2013
  3. ncbi Bacteriocins from lactic acid bacteria: production, purification, and food applications
    Luc De Vuyst
    Department of Applied Biological Sciences and Engineering, Research Group of Industrial Microbiology and Food Biotechnology, Vrije Universiteit Brussel, Brussels, Belgium
    J Mol Microbiol Biotechnol 13:194-9. 2007
  4. ncbi Biosynthesis and mode of action of lantibiotics
    Champak Chatterjee
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, Illinois, USA
    Chem Rev 105:633-84. 2005
  5. ncbi Lantibiotics: mode of action, biosynthesis and bioengineering
    G Bierbaum
    Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Curr Pharm Biotechnol 10:2-18. 2009
  6. ncbi Bacteriocins: evolution, ecology, and application
    Margaret A Riley
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511, USA
    Annu Rev Microbiol 56:117-37. 2002
  7. ncbi Lantibiotics: peptides of diverse structure and function
    Joanne M Willey
    Department of Biology, Hofstra University, Hempstead, New York 11549, USA
    Annu Rev Microbiol 61:477-501. 2007
  8. ncbi Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides
    A Peschel
    Mikrobielle Genetik, Universitat Tubingen, Waldhäuser Strasse 70 8, 72076 Tubingen, Germany
    J Biol Chem 274:8405-10. 1999
  9. ncbi Lipid II as a target for antibiotics
    Eefjan Breukink
    Department of Biochemistry of Membranes, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands
    Nat Rev Drug Discov 5:321-32. 2006
  10. ncbi Enterococcal cytolysin: a novel two component peptide system that serves as a bacterial defense against eukaryotic and prokaryotic cells
    Christopher R Cox
    Oklahoma Center for Neuroscience, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Curr Protein Pept Sci 6:77-84. 2005

Detail Information

Publications363 found, 100 shown here

  1. ncbi Bacteriocins: developing innate immunity for food
    Paul D Cotter
    Alimentary Pharmabiotic Centre, Microbiology Department, University College Cork, Cork, Ireland
    Nat Rev Microbiol 3:777-88. 2005
    b>Bacteriocins are bacterially produced antimicrobial peptides with narrow or broad host ranges...
  2. ncbi Bacteriocins - a viable alternative to antibiotics?
    Paul D Cotter
    Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland
    Nat Rev Microbiol 11:95-105. 2013
    Solutions are urgently required for the growing number of infections caused by antibiotic-resistant bacteria. Bacteriocins, which are antimicrobial peptides produced by certain bacteria, might warrant serious consideration as alternatives ..
  3. ncbi Bacteriocins from lactic acid bacteria: production, purification, and food applications
    Luc De Vuyst
    Department of Applied Biological Sciences and Engineering, Research Group of Industrial Microbiology and Food Biotechnology, Vrije Universiteit Brussel, Brussels, Belgium
    J Mol Microbiol Biotechnol 13:194-9. 2007
    ..This is mainly due to the production of organic acids, but also of other compounds, such as bacteriocins and antifungal peptides. Several bacteriocins with industrial potential have been purified and characterized...
  4. ncbi Biosynthesis and mode of action of lantibiotics
    Champak Chatterjee
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, Illinois, USA
    Chem Rev 105:633-84. 2005
  5. ncbi Lantibiotics: mode of action, biosynthesis and bioengineering
    G Bierbaum
    Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Curr Pharm Biotechnol 10:2-18. 2009
    ..Furthermore, variant lantibiotics with enhanced properties have been engineered and at least one promising new lantibiotic with strong activity against multiresistant pathogens has been described...
  6. ncbi Bacteriocins: evolution, ecology, and application
    Margaret A Riley
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06511, USA
    Annu Rev Microbiol 56:117-37. 2002
    ..include classical antibiotics, metabolic by-products, lytic agents, numerous types of protein exotoxins, and bacteriocins. The abundance and diversity of this potent arsenal of weapons are clear...
  7. ncbi Lantibiotics: peptides of diverse structure and function
    Joanne M Willey
    Department of Biology, Hofstra University, Hempstead, New York 11549, USA
    Annu Rev Microbiol 61:477-501. 2007
    ....
  8. ncbi Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides
    A Peschel
    Mikrobielle Genetik, Universitat Tubingen, Waldhäuser Strasse 70 8, 72076 Tubingen, Germany
    J Biol Chem 274:8405-10. 1999
    ..We propose a role of the D-alanine-esterified teichoic acids which occur in many pathogenic bacteria in the protection against human and animal defense systems...
  9. ncbi Lipid II as a target for antibiotics
    Eefjan Breukink
    Department of Biochemistry of Membranes, Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands
    Nat Rev Drug Discov 5:321-32. 2006
    ....
  10. ncbi Enterococcal cytolysin: a novel two component peptide system that serves as a bacterial defense against eukaryotic and prokaryotic cells
    Christopher R Cox
    Oklahoma Center for Neuroscience, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Curr Protein Pept Sci 6:77-84. 2005
    ..Cytolytic activity requires two unique peptides that possess modifications characteristic of the lantibiotic bacteriocins, and these peptides are broadly similar in size to most cationic eukaryotic defensins...
  11. pmc Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118
    Sinead C Corr
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Proc Natl Acad Sci U S A 104:7617-21. 2007
    ..monocytogenes expressing the cognate Abp118 immunity protein AbpIM, confirming that the antimicrobial effect is a result of direct antagonism between Lb. salivarius and the pathogen, mediated by the bacteriocin Abp118...
  12. ncbi Quorum sensing control of lantibiotic production; nisin and subtilin autoregulate their own biosynthesis
    Michiel Kleerebezem
    NIZO Food Research, Wageningen Centre for Food Sciences, Kernhemseweg 2, PO Box 20, 6710 BA Ede, The Netherlands
    Peptides 25:1405-14. 2004
    ..Finally, the exploitation of these regulatory characteristics for the development of highly effective controlled gene expression systems in Gram-positive bacteria is discussed...
  13. ncbi Evaluation of essential and variable residues of nukacin ISK-1 by NNK scanning
    Mohammad R Islam
    Laboratory of Microbial Technology, Division of Microbial Science and Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Mol Microbiol 72:1438-47. 2009
    ..We obtained two variants, Asp13Glu and Val22Ile, which exhibited a twofold higher specific activity compared with the wild-type and are the first reported type-A(II) lantibiotic mutant peptides with increased potency...
  14. pmc Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions
    Casie E Soltani
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 104:20226-31. 2007
    ..These studies provide an example of a structural motif that specifically mediates the interaction of a bacterial toxin with a cholesterol-rich membrane...
  15. ncbi An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II
    Hester E Hasper
    Department of Biochemistry of Membranes, Bijvoet Center for Biomolecular Research, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH, Utrecht, Netherlands
    Science 313:1636-7. 2006
    ..We describe an alternative mechanism by which members of the lantibiotic family kill Gram-positive bacteria by removing lipid II from the cell division site (or septum) and thus block cell wall synthesis...
  16. pmc BAGEL2: mining for bacteriocins in genomic data
    Anne De Jong
    Department of Molecular Genetics, University of Groningen, Groningen, The Netherlands
    Nucleic Acids Res 38:W647-51. 2010
    Mining bacterial genomes for bacteriocins is a challenging task due to the substantial structure and sequence diversity, and generally small sizes, of these antimicrobial peptides...
  17. ncbi Biosynthesis, immunity, regulation, mode of action and engineering of the model lantibiotic nisin
    J Lubelski
    Molecular Genetics Department, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    Cell Mol Life Sci 65:455-76. 2008
    ....
  18. ncbi The dawning of a 'Golden era' in lantibiotic bioengineering
    Des Field
    Department of Microbiology, University College Cork, Cork, Ireland
    Mol Microbiol 78:1077-87. 2010
    ..This review charts these recent developments which suggest that we are entering a 'Golden era' of lantibiotic bioengineering...
  19. ncbi Discovery, biosynthesis, and engineering of lantipeptides
    Patrick J Knerr
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Annu Rev Biochem 81:479-505. 2012
    ....
  20. ncbi MMBL proteins: from lectin to bacteriocin
    Maarten G K Ghequire
    Centre of Microbial and Plant Genetics, KU Leuven, Kasteelpark Arenberg 20, 3001 Heverlee, Belgium
    Biochem Soc Trans 40:1553-9. 2012
    Arguably, bacteriocins deployed in warfare among related bacteria are among the most diverse proteinacous compounds with respect to structure and mode of action...
  21. ncbi Crystal structure of cytotoxin protein suilysin from Streptococcus suis
    Lingfeng Xu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China
    Protein Cell 1:96-105. 2010
    ..This observation suggests that the current view of the structure-function relationship between CDC proteins and membrane association is far from complete...
  22. ncbi Production of antimicrobial substances by Bacillus subtilis LFE-1, B. firmus HO-1 and B. licheniformis T6-5 isolated from an oil reservoir in Brazil
    E Korenblum
    Departamento de Microbiologia Geral, Instituto de Microbiologia Prof Paulo de Góes IMPPG, Centro de Ciencias da Saude CCS, Universidade Federal do Rio de Janeiro UFRJ, Brazil
    J Appl Microbiol 98:667-75. 2005
    ..Furthermore, physiological and biochemical characteristics of the antimicrobial compounds produced by the selected strains were determined...
  23. ncbi Bacteria killing their own kind: novel bacteriocins of Pseudomonas and other gamma-proteobacteria
    Annabel H A Parret
    Trends Microbiol 10:107-12. 2002
  24. ncbi Detection and characterization of the novel bacteriocin entomocin 9, and safety evaluation of its producer, Bacillus thuringiensis ssp. entomocidus HD9
    A Cherif
    Laboratoire de Microbiologie, Departement de Biologie, Faculte des Sciences de Tunis, Campus Universitaire, Tunis, Tunisia
    J Appl Microbiol 95:990-1000. 2003
    To identify and characterize new bacteriocins from a collection of 41 strains belonging to 27 subspecies of Bacillus thuringiensis, and to evaluate the safety of the producers.
  25. pmc Genome mining demonstrates the widespread occurrence of gene clusters encoding bacteriocins in cyanobacteria
    Hao Wang
    Division of Microbiology, Department of Food and Environment Sciences, University of Helsinki, Helsinki, Finland
    PLoS ONE 6:e22384. 2011
    ..A new class of bacteriocins produced through the proteolytic cleavage and heterocyclization of precursor proteins was recently identified ..
  26. pmc Bacteriocin as weapons in the marine animal-associated bacteria warfare: inventory and potential applications as an aquaculture probiotic
    Florie Desriac
    Universite Europeenne de Bretagne, Universite de Brest, Institut Universitaire de Technologie, Laboratoire, Universitaire de Biodiversité et d Ecologie Microbienne EA3882, 6 rue de l Université, 29334 Quimper Cedex, France
    Mar Drugs 8:1153-77. 2010
    ..b>Bacteriocins, ribosomally synthesized antibiotic peptides, constitute one of the most potent weapons to fight against ..
  27. ncbi Structure-function relationships of the non-lanthionine-containing peptide (class II) bacteriocins produced by gram-positive bacteria
    J Nissen-Meyer
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    Curr Pharm Biotechnol 10:19-37. 2009
    This review focuses on the structure and mode-of-action of non-lanthionine-containing peptide bacteriocins produced by Gram-positive bacteria...
  28. pmc Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family
    Daniel H Haft
    The J Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
    BMC Biol 8:70. 2010
    ..TOMM peptides are small and highly variable, frequently missed by gene-finders and occasionally situated far from the thiazole/oxazole forming genes. Thus, locating a substrate for a particular TOMM pathway can be a challenging endeavor...
  29. ncbi Bacteriocin-based strategies for food biopreservation
    Antonio Galvez
    Area de Microbiologia, Facultad de Ciencias Experimentales, Universidad de Jaen, Spain
    Int J Food Microbiol 120:51-70. 2007
    b>Bacteriocins are ribosomally-synthesized peptides or proteins with antimicrobial activity, produced by different groups of bacteria. Many lactic acid bacteria (LAB) produce bacteriocins with rather broad spectra of inhibition...
  30. ncbi Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin
    Kara S Giddings
    Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Nat Struct Mol Biol 11:1173-8. 2004
    ..ILY specifically binds to huCD59 via residues that are the binding site for the C8alpha and C9 complement proteins. These studies provide a new model for the mechanism of cellular recognition by a CDC...
  31. ncbi Bacteriocins: safe, natural antimicrobials for food preservation
    J Cleveland
    Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick 08901, USA
    Int J Food Microbiol 71:1-20. 2001
    b>Bacteriocins are antibacterial proteins produced by bacteria that kill or inhibit the growth of other bacteria. Many lactic acid bacteria (LAB) produce a high diversity of different bacteriocins...
  32. pmc Plant lectin-like bacteriocin from a rhizosphere-colonizing Pseudomonas isolate
    Annabel H A Parret
    Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, Kasteelpark Arenberg 20, B 3001 Heverlee, Belgium
    J Bacteriol 185:897-908. 2003
    ..Most likely, the mode of action of this lectin-like bacteriocin is different from the modes of action of previously described Pseudomonas bacteriocins.
  33. ncbi The ecological role of bacteriocins in bacterial competition
    M A Riley
    Dept of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06511, USA
    Trends Microbiol 7:129-33. 1999
    b>Bacteriocins are an abundant class of antimicrobial molecules that appear to mediate population dynamics within species. The bacteriocins of Escherichia coli have served as a model for exploring the ecological role of these potent toxins...
  34. pmc Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin
    Galina Polekhina
    Biota Structural Biology Laboratory, St Vincent s Institute of Medical Research, 9 Princes Street, Fitzroy, Victoria 3065, Australia
    Proc Natl Acad Sci U S A 102:600-5. 2005
    ..We have determined the crystal structure of ILY, which, when compared to the known structure of a prototypical CDC, suggests that the basic aspects of its 3D structure are likely to be conserved in all CDCs...
  35. pmc An extracellular loop of the mannose phosphotransferase system component IIC is responsible for specific targeting by class IIa bacteriocins
    Morten Kjos
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, As, Norway
    J Bacteriol 192:5906-13. 2010
    Class IIa bacteriocins target a phylogenetically defined subgroup of mannose-phosphotransferase systems (man-PTS) on sensitive cells...
  36. pmc Discovery of a widely distributed toxin biosynthetic gene cluster
    Shaun W Lee
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:5879-84. 2008
    b>Bacteriocins represent a large family of ribosomally produced peptide antibiotics...
  37. pmc A simple model host for identifying Gram-positive virulence factors
    D A Garsin
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:10892-7. 2001
    ..We exploit the apparent parallels between Gram-positive infection in simple and more complex organisms by using the nematode to identify an E. faecalis virulence factor, ScrB, which is relevant to mammalian pathogenesis...
  38. pmc Lantibiotics as probes for phosphatidylethanolamine
    Ming Zhao
    Department of Biophysics, Medical College of Wisconsin, Milwaukee, 53226, USA
    Amino Acids 41:1071-9. 2011
    ..The utilities of lantibiotic-based molecular probes will help accelerate the characterization of PE as an abundant, yet elusive membrane component...
  39. pmc The cholesterol-dependent cytolysin signature motif: a critical element in the allosteric pathway that couples membrane binding to pore assembly
    Kelley J Dowd
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    PLoS Pathog 8:e1002787. 2012
    ..These studies show for the first time that the undecapeptide of the cholesterol-binding CDCs forms a critical element of the allosteric pathway that controls the assembly of the pore complex...
  40. pmc Production of multiple bacteriocins from a single locus by gastrointestinal strains of Lactobacillus salivarius
    Eileen F O'Shea
    Teagasc Food Research Centre, Moorepark, Fermoy, Co Cork, Ireland
    J Bacteriol 193:6973-82. 2011
    b>Bacteriocins produced by Lactobacillus salivarius isolates derived from a gastrointestinal origin have previously demonstrated efficacy for in vivo protection against Listeria monocytogenes infection...
  41. pmc Competitive interactions in Escherichia coli populations: the role of bacteriocins
    Hadeel Majeed
    Zuckerberg Institute for Water Research, J Blaustein Institutes for Desert Research, Ben Gurion University, Sde Boqer Campus, Israel
    ISME J 5:71-81. 2011
    ..In bacterial systems, competition is often driven by the production of bacteriocins, which are narrow-spectrum proteinaceous toxins that serve to kill closely related species, providing the ..
  42. pmc Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13
    Jasmin Dischinger
    Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany
    PLoS ONE 4:e6788. 2009
    ..The structural gene (lanA) as well as the other genes which are involved in lantibiotic modification (lanM, lanB, lanC, lanP), regulation (lanR, lanK), export (lanT(P)) and immunity (lanEFG) are organized in biosynthetic gene clusters...
  43. ncbi Production of bioactive substances by intestinal bacteria as a basis for explaining probiotic mechanisms: bacteriocins and conjugated linoleic acid
    Eileen F O'Shea
    Teagasc Food Research Centre, Moorepark, Fermoy, Co Cork, Ireland
    Int J Food Microbiol 152:189-205. 2012
    ..b>Bacteriocins and fatty acids are just two examples of pharmabiotic substances which may contribute to probiotic ..
  44. pmc Native microbial colonization of Drosophila melanogaster and its use as a model of Enterococcus faecalis pathogenesis
    Christopher R Cox
    The Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Infect Immun 75:1565-76. 2007
    ..The anatomical distribution of enterococci in the Drosophila GI tract was determined by immunohistochemical staining of thin sections of naturally colonized and reassociated flies...
  45. ncbi Overexpression, purification and crystallization of bacteriocin LlpA from Pseudomonas sp. BW11M1
    Annabel H A Parret
    Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, 3001 Heverlee, Belgium
    Acta Crystallogr D Biol Crystallogr 60:1922-4. 2004
    ..Single crystals were grown by vapour diffusion and belong to space group P2(1)2(1)2, with unit-cell parameters a = 150.5, b = 154.5, c = 34.2 A. The crystals diffract to at least 2.2 A using synchrotron radiation...
  46. pmc Transcription analysis of a lantibiotic gene cluster from Bifidobacterium longum DJO10A
    Ju Hoon Lee
    Department of Food Science and Nutrition, Microbial and Plant Genomics Institute, University of Minnesota, 1500 Gortner Ave, St Paul, MN 55108, USA
    Appl Environ Microbiol 77:5879-87. 2011
    ..Understanding the transcription regulation of this lanA gene is the first step toward enabling production of this novel and potentially interesting lantibiotic in broth cultures...
  47. pmc The crystal structure of the lipid II-degrading bacteriocin syringacin M suggests unexpected evolutionary relationships between colicin M-like bacteriocins
    Rhys Grinter
    Institute of Infection, Immunity, and Inflammation, School of Life Sciences, College of Medical, Veterinary, and Life Sciences, University of Glasgow, Glasgow G12 8TA, Scotland, United Kingdom
    J Biol Chem 287:38876-88. 2012
    Colicin-like bacteriocins show potential as next generation antibiotics with clinical and agricultural applications...
  48. ncbi Pheromone-induced expression of recombinant proteins in Streptococcus thermophilus
    Trinelise Blomqvist
    Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, P O Box 5003, 1432, As, Norway
    Arch Microbiol 186:465-73. 2006
    ..thermophilus LMG 18311, and show that the StbABCHR quorum-sensing system can be exploited for inducible expression of recombinant proteins in this bacterial species...
  49. ncbi Bacteriocin-like substance production by Bacillus licheniformis strain P40
    F Cladera-Olivera
    Laboratorio de Bioquimica e Microbiologia Aplicada, Departamento de Ciencia de Alimentos, ICTA, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
    Lett Appl Microbiol 38:251-6. 2004
    ..To investigate the production of bacteriocin-like compounds by Bacillus spp. isolated from the Amazon basin...
  50. pmc Salivaricin P, one of a family of two-component antilisterial bacteriocins produced by intestinal isolates of Lactobacillus salivarius
    Eoin Barrett
    Teagasc Biotechnology Centre, Moorepark Food Research Centre, Fermoy, Co Cork, Ireland
    Appl Environ Microbiol 73:3719-23. 2007
    ..This observation suggests that two-component bacteriocins may be a common feature of intestinal L. salivarius strains.
  51. ncbi The Enterococcus faecalis cytolysin: a novel toxin active against eukaryotic and prokaryotic cells
    Phillip S Coburn
    Department of Microbiology and Immunology, Stanton L Young Biomedical Research Center, Rm 356, The University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Cell Microbiol 5:661-9. 2003
    The enterococcal cytolysin, a two-peptide lytic system, is a divergent relative of a large family of toxins and bacteriocins secreted by pathogenic and non-pathogenic Gram-positive bacteria...
  52. pmc Effect of Streptococcus salivarius K12 on the in vitro growth of Candida albicans and its protective effect in an oral candidiasis model
    Sanae A Ishijima
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    Appl Environ Microbiol 78:2190-9. 2012
    ..S. salivarius K12 may be useful as a probiotic as a protective tool for oral care, especially with regard to candidiasis...
  53. pmc Isolation and identification of a bacteriocin with antibacterial and antibiofilm activity from Citrobacter freundii
    Robert M Q Shanks
    Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Microbiol 194:575-87. 2012
    ..coli, Citrobacter species, and Klebsiella pneumoniae cells in a planktonic and biofilm state. This study suggests that bacteriocins can be an effective way to control surface-attached pathogenic bacteria.
  54. pmc Effect of Lactobacillus salivarius bacteriocin Abp118 on the mouse and pig intestinal microbiota
    Eliette Riboulet-Bisson
    Department of Microbiology, University College Cork, Cork, Ireland
    PLoS ONE 7:e31113. 2012
    ..Thus L. salivarius UCC118 administration has a significant but subtle impact on mouse and pig microbiota, by a mechanism that seems at least partially bacteriocin-dependent...
  55. ncbi A comparison of the activities of lacticin 3147 and nisin against drug-resistant Staphylococcus aureus and Enterococcus species
    Clare Piper
    Department of Microbiology, University College Cork, College Road, Cork, Ireland
    J Antimicrob Chemother 64:546-51. 2009
    ..Our goal was to compare the activities of lacticin 3147 and nisin, two of the most well characterized lantibiotics, against antibiotic-resistant staphylococci and enterococci...
  56. pmc Entianin, a novel subtilin-like lantibiotic from Bacillus subtilis subsp. spizizenii DSM 15029T with high antimicrobial activity
    Sebastian W Fuchs
    Institute for Molecular Biosciences, Max von Laue Str 9, Goethe University Frankfurt, D 60438 Frankfurt, Germany
    Appl Environ Microbiol 77:1698-707. 2011
    ..Remarkably, S-entianin and S-subtilin showed considerable autoinduction activity, clearly demonstrating that autoinduction and antibiotic activity underlie different molecular mechanisms...
  57. pmc Bacteriocin diversity in Streptococcus and Enterococcus
    Ingolf F Nes
    Laboratory of Microbial Gene Technology, Norwegian University of Life Sciences, N 1432 As, Norway
    J Bacteriol 189:1189-98. 2007
  58. ncbi Bacteriocins: modes of action and potentials in food preservation and control of food poisoning
    T Abee
    Food Chemistry and Microbiology Section, Department of Food Science, Wageningen Agricultural University, Bomenweg, The Netherlands
    Int J Food Microbiol 28:169-85. 1995
    ..for nutrients and the presence of starter-derived inhibitors such as lactic acid, hydrogen peroxide and bacteriocins (Ray and Daeschel, 1992)...
  59. pmc Production of the Bsa lantibiotic by community-acquired Staphylococcus aureus strains
    Karen M Daly
    Department of Microbiology, University College Cork, Cork, Ireland
    J Bacteriol 192:1131-42. 2010
    ..aureus...
  60. pmc Role of bacteriocins in mediating interactions of bacterial isolates taken from cystic fibrosis patients
    Suphan Bakkal
    Department of Biology, University of Massachusetts Amherst, 611 North Pleasant Street, Amherst, MA 01003, USA
    Microbiology 156:2058-67. 2010
    ..These data suggest that bacteriocin-based inhibition may play a role in governing Pa and Bcc interactions in the CF lung and may, therefore, offer a novel approach to mediating these often fatal infections...
  61. ncbi Production of class II bacteriocins by lactic acid bacteria; an example of biological warfare and communication
    Vincent G H Eijsink
    Agricultural University of Norway, Department of Chemistry and Biotechnology, As
    Antonie Van Leeuwenhoek 81:639-54. 2002
    ..acid bacteria (LAB) fight competing Gram-positive microorganisms by secreting anti-microbial peptides called bacteriocins. Peptide bacteriocins are usually divided into lantibiotics (class I) and non-lantibiotics (class II), the ..
  62. pmc Nine post-translational modifications during the biosynthesis of cinnamycin
    Ayse Okesli
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, United States
    J Am Chem Soc 133:13753-60. 2011
    ..A small protein encoded by cinorf7 is critical for the formation of the cross-link between Lys19 and dehydroalanine 6 as shown by coexpression studies of CinA, CinM, CinX, and Cinorf7 in E. coli...
  63. pmc Human- and plant-pathogenic Pseudomonas species produce bacteriocins exhibiting colicin M-like hydrolase activity towards peptidoglycan precursors
    Hélène Barreteau
    Universite Paris Sud, Institut de Biochimie et Biophysique Moleculaire et Cellulaire, UMR 8619, Orsay F 91405, France
    J Bacteriol 191:3657-64. 2009
    ..aeruginosa strains. These proteins thus represent a new class of bacteriocins (pyocins), the first ones reported thus far in the genus Pseudomonas that target peptidoglycan metabolism.
  64. ncbi Effect of bioengineering lacticin 3147 lanthionine bridges on specific activity and resistance to heat and proteases
    Srinivas Suda
    Department of Microbiology, University College Cork, Cork, Ireland
    Chem Biol 17:1151-60. 2010
    ..Although switching Lan and meLan bridges has variable consequences, it was consistently observed that an intact N-terminal lanthionine bridge (Ring A) confers Ltnα with enhanced resistance to thermal and proteolytic degradation...
  65. ncbi Solid supported chemical syntheses of both components of the lantibiotic lacticin 3147
    Wei Liu
    Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2G2
    J Am Chem Soc 133:14216-9. 2011
    ..Both successive and interlocking ring systems were synthesized on-resin, thereby providing a general methodology for this family of natural products...
  66. ncbi Production and partial characterization of bacteriocin-like pepitdes by Bacillus licheniformis ZJU12
    Lili He
    Institute of Biotechnology, Zhejiang University, Hangzhou 310029, China
    Microbiol Res 161:321-6. 2006
    ..5. No adverse effect of the antagonistic compound to mice was observed in acute toxicity tests with the dose of 0.8 mg/20 g...
  67. ncbi Pediocin PA-1 and a pediocin producing Lactobacillus plantarum strain do not change the HMA rat microbiota
    Nete Bernbom
    Department of Microbiology and Risk Assessment, National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Int J Food Microbiol 130:251-7. 2009
    ..Pediocin PA-1 did not mediate changes of the rat microbiota, and a biological assay indicated that the bacteriocin was degraded or inactivated during passage through the intestine...
  68. pmc Determination of essential and variable residues in pediocin PA-1 by NNK scanning
    Tatsuya Tominaga
    Saitama Industrial Technology Center North Institute, 2 133 Suehiro, Kumagaya, Saitama 360 0031, Japan
    Appl Environ Microbiol 72:1141-7. 2006
    ....
  69. ncbi Are bacteriocins underexploited? Novel applications for old antimicrobials
    Manuel Montalbán-López
    Departamento de Microbiologia, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain
    Curr Pharm Biotechnol 12:1205-20. 2011
    b>Bacteriocins are ribosomally synthesized (poly)peptides produced by almost all prokaryotic lineages...
  70. ncbi Thuricin 7: a novel bacteriocin produced by Bacillus thuringiensis BMG1.7, a new strain isolated from soil
    A Cherif
    Laboratoire de Microbiologie, Departement de Biologie, Faculte des Sciences de Tunis, Tunisia
    Lett Appl Microbiol 32:243-7. 2001
    ..Detection and identification of new antagonistic activities towards Bacillus cereus and relatives...
  71. ncbi Purification and characterization of a bacteriocin-like compound (Lichenin) produced anaerobically by Bacillus licheniformis isolated from water buffalo
    P Pattnaik
    Molecular Biology Unit, Dairy Microbiology Division, National Dairy Research Institute, Karnal, India
    J Appl Microbiol 91:636-45. 2001
    ..No homology with previously reported bacteriocins was observed and has been designated as Lichenin...
  72. ncbi Cell-cell communication in gram-positive bacteria
    G M Dunny
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455, USA
    Annu Rev Microbiol 51:527-64. 1997
    ..The microbial processes controlled by extracellular signaling include the expression of virulence factors, the expression of gene transfer functions, and the production of antibiotics...
  73. ncbi Fundamental functionality: recent developments in understanding the structure-activity relationships of lantibiotic peptides
    Avena C Ross
    Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada
    J Antibiot (Tokyo) 64:27-34. 2011
    ..This review will focus on the individual systems and the valuable information obtained from the many mutants produced...
  74. pmc Purification and characterization of a novel class IIa bacteriocin, piscicocin CS526, from surimi-associated Carnobacterium piscicola CS526
    Koji Yamazaki
    Laboratory of Marine Food Science, Graduate School of Fisheries Sciences, Hokkaido University, 3 1 1 Minato, Hakodate 041 8611, Japan
    Appl Environ Microbiol 71:554-7. 2005
    ..The N-terminal sequence was YGNGL, not the YGNGV consensus motif common in class IIa bacteriocins (alternate residues underlined)...
  75. ncbi Virulence factors of Enterococcus faecalis and Enterococcus faecium blood culture isolates
    H A Elsner
    Abteilung für Transfusionsmedizin, Medizinische Hochschule Hannover, Germany
    Eur J Clin Microbiol Infect Dis 19:39-42. 2000
    ..The significance of these factors in the pathogenesis of enterococcal infection needs to be elucidated in further studies...
  76. ncbi Chapter 21. In vitro studies of lantibiotic biosynthesis
    Bo Li
    Department of Chemistry and the Howard Hughes Medical Institute, University of Illinois, Urbana, Illinois, USA
    Methods Enzymol 458:533-58. 2009
    ..Several of the enzymatic reactions involved in lantibiotic biosynthesis have been reconstituted in vitro in recent years and these systems as well as a general overview of lantibiotic biosynthesis are discussed in this chapter...
  77. ncbi Cysteine S-glycosylation, a new post-translational modification found in glycopeptide bacteriocins
    Judith Stepper
    Institute of Molecular Biosciences, Massey University, Palmerston North, New Zealand
    FEBS Lett 585:645-50. 2011
    ..no confirmed examples of sidechain glycosylation in ribosomal antimicrobial polypeptides collectively known as bacteriocins. Here we show that glycocin F, a bacteriocin secreted by Lactobacillus plantarum KW30, is modified by an N-..
  78. ncbi Involvement of the mpo operon in resistance to class IIa bacteriocins in Listeria monocytogenes
    Safia Arous
    MFA, Laboratoire de Chimie de l Ean et de l Environnement, UMR CNRA 6008, Universite de Poitiers, 40 Avenue du Recteur Pineau, 86022 Poitiers Cedex, France
    FEMS Microbiol Lett 238:37-41. 2004
    High resistance to class IIa bacteriocins in Listeria monocytogenes has been clearly linked to lack of expression of the mptACD operon, encoding the EIIt Man mannose PTS permease...
  79. pmc Novel lectin-like bacteriocins of biocontrol strain Pseudomonas fluorescens Pf-5
    Annabel H A Parret
    Centre of Microbial and Plant Genetics, Katholieke Universiteit Leuven, Kasteelpark Arenberg 20, B 3001 Heverlee, Belgium
    Appl Environ Microbiol 71:5197-207. 2005
    ..fluorescens strains, as well as the related mushroom pathogen Pseudomonas tolaasii. LlpA-type bacteriocins are characterized by a domain structure consisting of tandem monocot mannose-binding lectin (MMBL) domains...
  80. ncbi Diversity and applications of Bacillus bacteriocins
    Hikmate Abriouel
    Departamento de Ciencias de la Salud, Area de Microbiologia, Facultad de Ciencias Experimentales, Universidad de Jaen, Jaen, Spain
    FEMS Microbiol Rev 35:201-32. 2011
    ..known to produce a wide arsenal of antimicrobial substances, including peptide and lipopeptide antibiotics, and bacteriocins. Many of the Bacillus bacteriocins belong to the lantibiotics, a category of post-translationally modified ..
  81. pmc The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV
    F Qi
    Department of Oral Biology, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Appl Environ Microbiol 67:15-21. 2001
    ..Mutacin II is a member of subgroup AII in the lantibiotic family of bacteriocins, and mutacins I and III belong to subgroup AI in the lantibiotic family...
  82. pmc Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile
    Mary C Rea
    Biotechnology Department, Teagasc, Moorepark Food Research Centre, Fermoy, Ireland
    Proc Natl Acad Sci U S A 107:9352-7. 2010
    ..Thuricin CD is a two-component antimicrobial peptide system with sulfur to alpha-carbon linkages, and it may have potential as a targeted therapy in the treatment of CDAD while also reducing collateral impact on the commensal flora...
  83. pmc Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis
    Raymond W Bourdeau
    Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:14645-56. 2009
    ..Novel structural elements and unique cellular functions of ALO revealed by our studies provide new insight into the molecular basis for the diverse nature of the CDC family...
  84. ncbi Bacteriocin diversity: ecological and evolutionary perspectives
    Margaret A Riley
    Department of Ecology and Evolutionary Biology, 165 Prospect Street, Yale University, New Haven, CT 06511, USA
    Biochimie 84:357-64. 2002
    The bacteriocin family is the most abundant and diverse group of bacterial defense systems. Bacteriocins range from the well-studied narrow spectrum, high molecular weight colicins produced by Escherichia coli and the short polypeptide ..
  85. ncbi Two-peptide lantibiotics: a medical perspective
    Elaine M Lawton
    Department of Microbiology, University College Cork, Cork, Ireland
    Mini Rev Med Chem 7:1236-47. 2007
    ....
  86. ncbi Microcins, gene-encoded antibacterial peptides from enterobacteria
    Sophie Duquesne
    Laboratory of Chemistry and Biochemistry of Natural Substances, UMR 5154 CNRS, Department of Regulations, Development and Molecular Diversity, National Museum of Natural History, CP 54, 57 rue Cuvier, 75005, Paris, France
    Nat Prod Rep 24:708-34. 2007
    ..This review provides an updated overview of microcin structures, antibacterial activities, genetic systems and biosyntheses, as well as of their mechanisms of action...
  87. pmc The dual role of bacteriocins as anti- and probiotics
    O Gillor
    Department of Environmental Hydrology and Microbiology, Zuckerberg Institute for Water Research, J Blaustein Institutes for Desert Research, Ben Gurion University of the Negev, Sde Boker Campus, Beersheba, 84990, Israel
    Appl Microbiol Biotechnol 81:591-606. 2008
    ..The most commonly encountered of these are bacteriocins, a large and functionally diverse family of antimicrobials found in all major lineages of Bacteria...
  88. ncbi A phylogenetic approach to assessing the targets of microbial warfare
    M A Riley
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520 8106, USA
    J Evol Biol 16:690-7. 2003
    b>Bacteriocins are the most abundant and diverse defense systems in bacteria...
  89. pmc Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights
    Yuki Goto
    Department of Chemistry, University of Illinois at Urbana Champaign, Urbana, Illinois, United States of America
    PLoS Biol 8:e1000339. 2010
    ....
  90. ncbi Discovery of medically significant lantibiotics
    Clare Piper
    Department of Microbiology, University College Cork, Cork, Ireland
    Curr Drug Discov Technol 6:1-18. 2009
    ..In so doing we highlight how some, or all, of these approaches have the potential to result in the development of clinically important drugs...
  91. pmc Genetic analysis of a unique bacteriocin, Smb, produced by Streptococcus mutans GS5
    Hideo Yonezawa
    Department of Oral Biology, State University of New York, 3435 Main St, Buffalo, NY 14214, USA
    Antimicrob Agents Chemother 49:541-8. 2005
    ..These results suggest that Smb belongs to the class I bacteriocin family, and its expression is dependent on CSP-induced quorum sensing...
  92. pmc Isolation of a Lactobacillus salivarius strain and purification of its bacteriocin, which is inhibitory to Campylobacter jejuni in the chicken gastrointestinal system
    N J Stern
    USDA ARS, Russell Research Center, Athens, GA 30604, USA
    Antimicrob Agents Chemother 50:3111-6. 2006
    ..The determined amino acid sequence was consistent with class IIa bacteriocins. Interestingly, OR-7 had sequence similarity, even in the C-terminal region, to acidocin A, which was ..
  93. pmc Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes
    Lucy C Foulston
    John Innes Centre, Norwich NR4 7UH, United Kingdom
    Proc Natl Acad Sci U S A 107:13461-6. 2010
    ....
  94. ncbi Streptococcus rattus strain BHT produces both a class I two-component lantibiotic and a class II bacteriocin
    Otto Hyink
    Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand
    FEMS Microbiol Lett 252:235-41. 2005
    ..rattus BHT produces two quite different types of bacteriocin activity, named BHT-A and BHT-B. The two bacteriocins were purified and analysed for activity and by MALDI-TOF mass spectrophotometry...
  95. pmc Studies with bioengineered Nisin peptides highlight the broad-spectrum potency of Nisin V
    Des Field
    Department of Microbiology, University College Cork, Cork, Ireland
    Microb Biotechnol 3:473-86. 2010
    ..Significantly, this enhanced activity was validated in a model food system against L. monocytogenes. We conclude that Nisin V possesses significant potential as a novel preservative or chemotherapeutic compound...
  96. ncbi The C-terminal domain of pediocin-like antimicrobial peptides (class IIa bacteriocins) is involved in specific recognition of the C-terminal part of cognate immunity proteins and in determining the antimicrobial spectrum
    Line Johnsen
    Program for Biochemistry and Molecular Biology, Department of Molecular Biosciences, University of Oslo, Oslo 0316, Norway
    J Biol Chem 280:9243-50. 2005
    The pediocin-like bacteriocins contain two domains: a cationic N-terminal beta-sheet domain that mediates binding of the bacteriocin to the target cell surface and a more hydrophobic C-terminal hairpin-like domain that penetrates into the ..
  97. pmc Specific protein-membrane contacts are required for prepore and pore assembly by a cholesterol-dependent cytolysin
    Casie E Soltani
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 282:15709-16. 2007
    ..These studies reveal that pore formation by ILY, and probably other CDCs, is affected by an intricate and coupled sequence of interactions between domain 4 and the membrane...
  98. pmc Intermedilysin-receptor interactions during assembly of the pore complex: assembly intermediates increase host cell susceptibility to complement-mediated lysis
    Stephanie LaChapelle
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Biol Chem 284:12719-26. 2009
    ..We further show that the assembly intermediates increase the sensitivity of the host cell to lysis by its complement membrane attack complex, apparently by blocking the hCD59-binding site for complement proteins C8alpha and C9...
  99. ncbi Predominance of a bacteriocin-producing Lactobacillus salivarius component of a five-strain probiotic in the porcine ileum and effects on host immune phenotype
    Maria C Walsh
    Department of Animal Science, Purdue University, West Lafayette, IN, USA
    FEMS Microbiol Ecol 64:317-27. 2008
    ..The findings also suggest that the five-strain combination may function as a probiotic, at least in part, via immunomodulation...
  100. ncbi New developments and applications of bacteriocins and peptides in foods
    S Mills
    Food for Health Ireland, Moorepark Food Research Center, Fermoy, County Cork, Ireland
    Annu Rev Food Sci Technol 2:299-329. 2011
    ..The best known examples of biopreservation involve bacteriocins. However, with the exception of nisin, bacteriocins have received limited use in the food industry...
  101. ncbi Isolation, structure elucidation, and synergistic antibacterial activity of a novel two-component lantibiotic lichenicidin from Bacillus licheniformis VK21
    Zakhar O Shenkarev
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho Maklaya Str 16 10, Moscow, Russia
    Biochemistry 49:6462-72. 2010
    ..Our results afford molecular insight into the mechanism of lichenicidin VK21 action...

Research Grants48

  1. Bacteriocins inhibiting growth of vaginal lactobacilli
    Vivien Pybus; Fiscal Year: 2004
    ..in my laboratory show that certain strains of vaginal enterococci can produce a class of antibiotics known as bacteriocins, which inhibit the growth of vaginal lactobacilli in vitro...
  2. Coordinate regulation of competence and pneumocin production in S. pneumoniae
    SUZANNE RACHEL DAWID; Fiscal Year: 2013
    ..The production of lytic pneumococcal bacteriocins (pneumocins) from the blp locus has the potential to expand the target range for DNA release...
  3. Impact of the Nasal Microbiome on S. aureus Colonization and Infection
    Mary Bessesen; Fiscal Year: 2013
    ..Possibilities include development of probiotic therapies, identification of bacteriocins produced by MRSA-inhibitory commensals, which may be applied to the nares or other body sites to prevent ..
  4. 3rd ASM Conference on Enterococci
    Don B Clewell; Fiscal Year: 2010
    ..sessions will cover: 1) molecular biology and genomics;2) virulence;3) antibiotic therapy and resistance;4) bacteriocins;5) plasmids and horizontal transfer;6) epidemiology and food connections;and 7) biofilms...
  5. Lactobacilli as a source of natural microbicides against HIV-1
    RUTH INGRID CONNOR; Fiscal Year: 2011
    ..Lactic acid bacteria also produce an array of antimicrobial molecules, termed bacteriocins, that are effective against competing organisms in the local milieu...
  6. Antimicrobial peptide resistance in Campylobacter jejuni
    Jun Lin; Fiscal Year: 2010
    ..Notably, several potent anti-Campylobacter bacteriocins, a group of AMPs produced by commensal bacteria, dramatically reduced C...
  7. Therapeutic intervention for Brucella
    AMY RAMBOW LARSEN; Fiscal Year: 2009
    ..treated Brucella will be performed to examine for distortion of the bacterial membrane as observed for other bacteriocins (8, 9)...
  8. Experiment based genome mining of ribosomal natural products
    Bradley S Moore; Fiscal Year: 2013
    ..to biosynthesize ribosomally- encoded, post-translationally modified natural products such as lantibiotics, bacteriocins, microcins, cyanobactins, thiopeptides, and lasso peptides, thereby making this class of underappreciated ..
  9. Bacterial and host factors in pneumococcal competition
    JEFFREY NEAL WEISER; Fiscal Year: 2013
    ..A mechanism that may underlie this intraspecies competition is based on the elaboration of pneumococcal bacteriocins (pneumocins)...
  10. Design and Use of Novel Bacteriocins
    Shaun Lee; Fiscal Year: 2011
    DESCRIPTION (Provided by the applicant) Abstract: Bacteriocins are a large class of ribosomally synthesized toxins that have been shown to be effective antibiotics, food preservatives, anti-infectives and anti-cancer therapeutics...
  11. Bacteriocins of the Intestinal Bacteroidales
    Laurie E Comstock; Fiscal Year: 2013
    ..This application addresses the production of bacterially-encoded antimicrobial molecules, known as bacteriocins. Bacteriocin production by intestinal Bacteroides spp...
  12. Non-Antibiotic Selectable Markers for Bacillus Anthracis
    James Kirby; Fiscal Year: 2009
    ..In the first, we will define the ability of markers conferring resistance to bacteriocins, heavy metals, chemotherapeutics, and herbicides to function as selectable markers in Bacillus anthracis...
  13. EXTRACHROMOSOMAL ELEMENTS IN GRAM NEGATIVE BACTERIA
    Roy Curtiss; Fiscal Year: 1980
    ..that confer resistance to chemotherapeutic drugs, that specify production of surface antigens, hemolysins, bacteriocins, toxins and other invasins and/or that alter biochemical traits so as to make clinical identification difficult,..
  14. ADDRESSING RESISTANCE IN ANTIMICROBIAL DESIGN
    ROBERT DORIT; Fiscal Year: 2000
    ..Employing the bacteriocins, a class of highly toxic, naturally occurring antimicrobials, as our model system, this proposal describes a ..
  15. Global Mechanisms of Bacteriocin Resistance in Listeria
    Kurt Miller; Fiscal Year: 2007
    ..L. monocytogenes in foods can be controlled by antimicrobial peptides known as class IIa bacteriocins. These peptides are produced by a number of beneficial lactic acid bacterial species that are used in food ..
  16. Evolution of Stress-Induced Bacterial Toxins
    Margaret A Riley; Fiscal Year: 2010
    b>Bacteriocins comprise a large, functionally diverse family of toxins often described as the microbial world's first choice in defense strategies...
  17. MOLECULAR EVOLUTION OF ENTERIC BACTERIOCINS
    Margaret Riley; Fiscal Year: 2002
    ..One class of antimicrobials, the bacteriocins, has received increasing attention because of the surprisingly high levels of bacteriocin diversity observed, ..
  18. Evolution of Antibiotic Resistance in Enteric Bacteria
    Margaret Riley; Fiscal Year: 2009
    ..abstract_text> ..
  19. Structure-based mutational analysis of RNA polymerase
    KONSTANTIN V SEVERINOV; Fiscal Year: 2010
    ..The proposed work is significant from the public health standpoint since information necessary for development of new and/or improved drugs that target bacterial transcription will be obtained. ..
  20. X-RAY CRYSTALLOGRAPHIC STUDIES OF TAQ RNA POLYMERASE
    Seth Darst; Fiscal Year: 2008
    ..Determine the crystal structure of RNAP with the transcription elongation factor GreA/B; 5. Determine the crystal structure of T. thermophilus sigma (E) holoenzyme. ..
  21. Symbiont Models for Natural Product Pathway Manipulation
    Eric W Schmidt; Fiscal Year: 2010
    ..This study will thus provide practical solutions to problems in drug discovery and development with marine natural products. ..
  22. Molecular epidemiologic identification of pneumococcal tissue specific genes
    MELINDA MARY PETTIGREW; Fiscal Year: 2010
    ..A greater understanding of the genetic factors that influence the virulence potential of pneumococcal clones is critical to our ability to develop effective methods to control, prevent, and treat these important infections. ..
  23. MOUSE MODELS OF DNA REPAIR - DEFECTIVE HUMAN DISEASES
    Errol Friedberg; Fiscal Year: 2011
    ..abstract_text> ..
  24. Structural Basis for Sporulation in Bacillus
    Seth A Darst; Fiscal Year: 2010
    ..4. Structurally characterize the ?F regulatory system (?F/SpollAA/SpollAB/SpollE) controlling the initiation of Bacillus sporulation. ..
  25. DNA REPAIR AND CANCER PRONE HEREDITARY HUMAN DISEASE
    Errol Friedberg; Fiscal Year: 2002
    ....
  26. Structure/Function of the Bacterial TRCF
    Seth Darst; Fiscal Year: 2008
    ..3. Determine the structural basis for the specific transcription termination activity of TRCF through structural studies of an RNAP ternary elongation complex (RNAP/DNA/RNA) with TRCF. ..
  27. DNA REPAIR AND ITS RELATIONSHIP TO CARCINOGENESIS
    Errol Friedberg; Fiscal Year: 2001
    ..There is reason to believe that the proteins encoded by these genes operate in a different chromatin-modulating complex, and it is proposed to isolate and characterize this putative complex as well. ..
  28. STRUCTURAL PARAMETERS OF E COLI RNA POLYMERASE
    Seth Darst; Fiscal Year: 2001
    ....
  29. Cell-cell communication in Streptomyces coelicolor
    Joanne Willey; Fiscal Year: 2004
    ..abstract_text> ..
  30. Single molecule analyses of RNA polymerase II elongation
    Karen Adelman; Fiscal Year: 2004
    ..abstract_text> ..
  31. Gene Discovery for Pneumococcal Otitis Media
    Melinda Pettigrew; Fiscal Year: 2005
    ..Discovery of additional factors involved in streptococcal OM will facilitate the development of new strategies for the control and prevention of this important disease. ..
  32. Differential Gene Expresion in Yersinia pestis
    Kathleen McDonough; Fiscal Year: 2005
    ..Characterization of Y. pestis-specific genes and their proteins in future studies will also identify potential mechanisms by which Y. pestis emerged as a new pathogen distinct from Yptb. ..
  33. Air Quality Improvements of The Animal Facility
    Michael Gilmore; Fiscal Year: 2005
    ..This will significantly improve the quality of vision research conducted by the Faculty at the Schepens. ..
  34. Resistant Enterococci in the GI tract Consortium
    Michael Gilmore; Fiscal Year: 2004
    ..Based on these results, well-grounded specific questions can be postulated and tested subsequently to verify their importance in vivo, ultimately leading to the design of agents to prevent colonization by antibiotic resistant strains. ..
  35. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  36. ORAL BIOFILMS: DIFFERENTIAL DISPLAY AND GENETIC EXCHANGE
    Michael Gilmore; Fiscal Year: 2003
    ..abstract_text> ..
  37. MECHANISTIC STUDIES ON PHOSPHORUS REDOX ENZYMES
    WILLEM VAN DER DONK; Fiscal Year: 2006
    ..The studies on HtxA focus on potential use of alternative substrates as well as developing a fundamental understanding of the mode of catalysis. ..
  38. Inorganic Antimicrobials in Exocrine Fluids
    Michael Ashby; Fiscal Year: 2008
    ..The ultimate objective of our research is the development of specific approaches to reduce pathogenic flora without altering the normal commensal (non-injurious) flora of the oral cavity. [unreadable] [unreadable] [unreadable]..
  39. Upgrade of in-house X-ray diffraction equipment
    Seth Darst; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  40. GLUCAN BINDING PROTEINS OF ORAL STREPTOCOCCI
    Jeffrey Banas; Fiscal Year: 2007
    ..abstract_text> ..
  41. Natural antimicrobials against bacterial vaginosis
    Michael Chikindas; Fiscal Year: 2006
    ..Our research will lead to a new approach for BV prophylaxis and treatment. ..
  42. Cell Wall Components' Role in Enterococcal Endocarditis
    Gary Dunny; Fiscal Year: 2006
    ..faecalis virulence. 2) Determine the functional domains of Asc10 that confer the activities identified in Aim 1. 3) Examine the expression of bacterial and host genes during the course of infections. ..
  43. Drosophila model of antibiotic resistant infection
    Michael Gilmore; Fiscal Year: 2006
    ..abstract_text> ..
  44. 2007 Vitamin B12 and Corphins Gordon Conference
    WILLEM VAN DER DONK; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  45. A BACTERIAL GROUP II INTRON INVOLVED IN CONJUGATION
    Gary Dunny; Fiscal Year: 2002
    ..Identification and analysis of small molecule splicing inhibitors using a splicing-dependent conjugation assay. ..
  46. Development and evaluation of subunit vaccine CmeC against Campylobacter jejuni
    Jun Lin; Fiscal Year: 2008
    ..S. The proposed research will provide novel information on the development of effective vaccine against C. jejuni to protect public health. [unreadable] [unreadable] [unreadable]..