avian proteins

Summary

Summary: Proteins obtained from species of BIRDS.

Top Publications

  1. ncbi Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Development 121:1321-32. 1995
  2. ncbi Neural crest emigration from the neural tube depends on regulated cadherin expression
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Development 125:2963-71. 1998
  3. ncbi Gene expression profiling reveals differentially expressed genes in ovarian cancer of the hen: support for oviductal origin?
    Lindsey S Trevino
    Department of Animal Science, Cornell University, Ithaca, NY, USA
    Horm Cancer 1:177-86. 2010
  4. ncbi A molecular clock operates during chick autopod proximal-distal outgrowth
    Susana Pascoal
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, 4710 057 Braga, Portugal
    J Mol Biol 368:303-9. 2007
  5. pmc A PHD12-Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition
    Pablo H Strobl-Mazzulla
    Biología del Desarrollo, Instituto de Investigaciones Biotecnológicas Instituto Tecnológico de Chascomús, Consejo Nacional de Investigaciones Científicas y Técnicas Universidad Nacional de San Martín, 7130 Chascomus, Argentina
    J Cell Biol 198:999-1010. 2012
  6. pmc The phylogenetic distribution of ultraviolet sensitivity in birds
    Anders Odeen
    Department of Animal Ecology, Uppsala University, Norbyvagen 18D, Uppsala S 752 36, Sweden
    BMC Evol Biol 13:36. 2013
  7. ncbi The metastasis-associated extracellular matrix protein osteopontin forms transient structure in ligand interaction sites
    Gerald Platzer
    Department of Structural and Computational Biology, Max F Perutz Laboratories, University of Vienna, Vienna Biocenter Campus 5, A 1030 Vienna, Austria
    Biochemistry 50:6113-24. 2011
  8. pmc Gene expression profiling to identify eggshell proteins involved in physical defense of the chicken egg
    Vincent Jonchère
    Institut National de la Recherche Agronomique, UR83 Recherches Avicoles, Nouzilly, France
    BMC Genomics 11:57. 2010
  9. pmc Lack of dosage compensation accompanies the arrested stage of sex chromosome evolution in ostriches
    Sofia Adolfsson
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 30:806-10. 2013
  10. ncbi Initiation of neural induction by FGF signalling before gastrulation
    A Streit
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Nature 406:74-8. 2000

Research Grants

  1. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2009
  2. Metabolic Regulation of Reproduction
    GREGORY FRALEY; Fiscal Year: 2006
  3. Completion of a Large Insertional Screen in Zebrafish
    Nancy Hopkins; Fiscal Year: 2005
  4. Cdx in GI Differentiation and Transdifferentiation
    Debra Silberg; Fiscal Year: 2005
  5. Analysis of the SARS Virus S glycoproteins
    Paul Bates; Fiscal Year: 2005
  6. CD4+ memory T cell recruitment by cyclophilin
    Michael Bukrinsky; Fiscal Year: 2004
  7. Understanding cell biology of Delta-Notch interactions
    GERALDINE WEINMASTER; Fiscal Year: 2006
  8. The Role of Vpr in HIV-1 Nuclear Translocation
    Michael Bukrinsky; Fiscal Year: 2006
  9. REGULATION OF INTESTINE-SPECIFIC GENE TRANSCRIPTION
    Eunran Suh; Fiscal Year: 2006
  10. Zebrafish in Comparative Context: A Symposium
    Thomas Schilling; Fiscal Year: 2006

Detail Information

Publications245 found, 100 shown here

  1. ncbi Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Japan
    Development 121:1321-32. 1995
    ..The cadherin-mediated specific interaction between crest cells likely plays a role in intercellular signaling between homotypic cells as well as in sorting of heterotypic cells...
  2. ncbi Neural crest emigration from the neural tube depends on regulated cadherin expression
    S Nakagawa
    Department of Biophysics, Faculty of Science, Kyoto University, Kitashirakawa, Sakyo ku, Kyoto 606 8502, Japan
    Development 125:2963-71. 1998
    ..These findings suggest that the regulation of cadherin expression or its activity at the neural crest-forming area plays a critical role in neural crest emigration from the neural tube...
  3. ncbi Gene expression profiling reveals differentially expressed genes in ovarian cancer of the hen: support for oviductal origin?
    Lindsey S Trevino
    Department of Animal Science, Cornell University, Ithaca, NY, USA
    Horm Cancer 1:177-86. 2010
    ..These data suggest that chicken ovarian tumors may arise from alternative sites, including the oviduct...
  4. ncbi A molecular clock operates during chick autopod proximal-distal outgrowth
    Susana Pascoal
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, 4710 057 Braga, Portugal
    J Mol Biol 368:303-9. 2007
    ..We suggest that temporal control exerted by cyclic gene expression can be a widespread mechanism providing cellular temporal information during vertebrate embryonic development...
  5. pmc A PHD12-Snail2 repressive complex epigenetically mediates neural crest epithelial-to-mesenchymal transition
    Pablo H Strobl-Mazzulla
    Biología del Desarrollo, Instituto de Investigaciones Biotecnológicas Instituto Tecnológico de Chascomús, Consejo Nacional de Investigaciones Científicas y Técnicas Universidad Nacional de San Martín, 7130 Chascomus, Argentina
    J Cell Biol 198:999-1010. 2012
    ....
  6. pmc The phylogenetic distribution of ultraviolet sensitivity in birds
    Anders Odeen
    Department of Animal Ecology, Uppsala University, Norbyvagen 18D, Uppsala S 752 36, Sweden
    BMC Evol Biol 13:36. 2013
    ..Whether birds are UVS or VS can nowadays be inferred from a wide range of species via genomic sequencing of the UV/violet SWS1 cone opsin gene...
  7. ncbi The metastasis-associated extracellular matrix protein osteopontin forms transient structure in ligand interaction sites
    Gerald Platzer
    Department of Structural and Computational Biology, Max F Perutz Laboratories, University of Vienna, Vienna Biocenter Campus 5, A 1030 Vienna, Austria
    Biochemistry 50:6113-24. 2011
    ..The conformational flexibility combined with the modular architecture of OPN may represent an important structural prerequisite for its functional diversity...
  8. pmc Gene expression profiling to identify eggshell proteins involved in physical defense of the chicken egg
    Vincent Jonchère
    Institut National de la Recherche Agronomique, UR83 Recherches Avicoles, Nouzilly, France
    BMC Genomics 11:57. 2010
    ..An extensive bioinformatic analysis on genes over-expressed in the uterus allowed us to identify novel eggshell proteins that contribute to the egg's natural defenses...
  9. pmc Lack of dosage compensation accompanies the arrested stage of sex chromosome evolution in ostriches
    Sofia Adolfsson
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 30:806-10. 2013
    ..Our results indicate that dosage compensation is a prerequisite for, not only a consequence of, sex chromosome evolution...
  10. ncbi Initiation of neural induction by FGF signalling before gastrulation
    A Streit
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Nature 406:74-8. 2000
    ..We show that the organizer and some of its precursor cells produce a fibroblast growth factor signal, which can initiate, and is required for, neural induction...
  11. ncbi A novel avian hypothalamic peptide inhibiting gonadotropin release
    K Tsutsui
    Laboratory of Brain Science, Hiroshima University, Higashi Hiroshima, 739 8521, Japan
    Biochem Biophys Res Commun 275:661-7. 2000
    ..This is the first hypothalamic peptide inhibiting gonadotropin release reported in a vertebrate. We therefore term it gonadotropin-inhibitory hormone (GnIH)...
  12. ncbi Jagged 1 regulates the restriction of Sox2 expression in the developing chicken inner ear: a mechanism for sensory organ specification
    Joana Neves
    CEXS, Universitat Pompeu Fabra, Parc de Recerca Biomedica de Barcelona, C Dr Aiguader 88, 08003 Barcelona, Spain
    Development 138:735-44. 2011
    ..This provides a mechanism to couple patterning and cell fate specification during the development of sensory organs...
  13. pmc Dopamine receptors in a songbird brain
    Lubica Kubikova
    Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Comp Neurol 518:741-69. 2010
    ..Our findings are consistent with hypotheses that dopamine receptors may be involved in song development and social context-dependent behaviors...
  14. ncbi A novel G protein-coupled receptor for gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica): identification, expression and binding activity
    H Yin
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    J Endocrinol 184:257-66. 2005
    ..These results suggest that GnIH acts directly on the pituitary via GnIH receptor to inhibit gonadotropin release. GnIH may also act on the hypothalamus to inhibit gonadotropin-releasing hormone release...
  15. ncbi Differential responsiveness in brain and behavior to sexually dimorphic long calls in male and female zebra finches
    Sharon M H Gobes
    Behavioural Biology and Helmholtz Institute, Utrecht University, 3508 TB Utrecht, The Netherlands
    J Comp Neurol 516:312-20. 2009
    ..Thus, male and female zebra finches both show a behavioral preference for female calls, but differential neuronal activation in response to sexually dimorphic calls...
  16. ncbi The chicken egg yolk plasma and granule proteomes
    Karlheinz Mann
    Max Planck Institut fur Biochemie, Abteilung Proteomics und Signaltransduktion, Am Klopferspitz 18, Martinsried, Germany
    Proteomics 8:178-91. 2008
    ..The list of chicken egg yolk proteins provided in this report is by far the most comprehensive at present and may serve as a starting point for the characterization of less well-known yolk proteins...
  17. pmc Characterization of the histone H2A.Z-1 and H2A.Z-2 isoforms in vertebrates
    Deanna Dryhurst
    Department of Biochemistry and Microbiology and The Center for Biomedical Research, University of Victoria, Petch Building, Victoria, BC, V8W 3P6, Canada
    BMC Biol 7:86. 2009
    ..Z mediates its effects are not entirely understood. However, it is now known that H2A.Z has two protein isoforms in vertebrates, H2A.Z-1 and H2A.Z-2, which are encoded by separate genes and differ by 3 amino acid residues...
  18. ncbi Proteomic analysis of the chicken egg vitelline membrane
    Karlheinz Mann
    Max Planck Institut fur Biochemie, Abteilung Proteomics und Signaltransduktion, Martinsried, Germany
    Proteomics 8:2322-32. 2008
    ..The list of VM proteins presented in this report is by far the most comprehensive dataset available at present and complements proteomic analyses of chicken egg compartments published previously...
  19. pmc Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6
    Jason R Spence
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Mol Vis 13:57-65. 2007
    ..To elucidate the early cellular events that take place during induction of retina regeneration in the embryonic chick, focusing on the relationship between fibroblast growth factor (FGF) signaling and the regulation of Pax6 and Mitf...
  20. ncbi Olive oil-supplemented diet alleviates acute heat stress-induced mitochondrial ROS production in chicken skeletal muscle
    Ahmad Mujahid
    Nutritional Biochemistry of Animals, Life Sciences, Graduate School of Agricultural Science, Tohoku Univ, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Am J Physiol Regul Integr Comp Physiol 297:R690-8. 2009
    ..These results show that under heat stress, mitochondrial ROS production and olive oil-induced reduction of ROS production may occur due to changes in respiratory chain activity as well as avUCP expression in skeletal muscle mitochondria...
  21. ncbi Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ
    Marieangela C Wilson
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 277:3666-72. 2002
    ..FRET may provide a non-invasive technique for measuring changes in these interactions in living cells...
  22. ncbi The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway
    Georgina Mosedale
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Struct Mol Biol 12:763-71. 2005
    ..This discovery sheds light on the origins, regulation and molecular function of the FA tumor-suppressor pathway in the maintenance of genome stability...
  23. ncbi Identification of a new gene family specifically expressed in chicken embryonic stem cells and early embryo
    H Acloque
    Laboratoire de Biologie Moléculaire et Cellulaire de l Ecole Normale Supérieure de Lyon, CNRS UMR5665, INRA LA 913, 46 allee d Italie, 69364 Lyon Cedex 07, France
    Mech Dev 103:79-91. 2001
    ..In the cENS we identified a promoter region whose activity is strong in CES cells and decreases after induced differentiation showing a highly specific transcriptional activity specific of undifferentiated chicken embryonic stem cells...
  24. ncbi Molecular and morphological evidences place the extinct New Zealand endemic Turnagra capensis in the Oriolidae
    Dario Zuccon
    Dario Zuccon, Molecular Systematics Laboratory, Swedish Museum of Natural History, Box 50007, SE 104 05 Stockholm, Sweden
    Mol Phylogenet Evol 62:414-26. 2012
    ..We show also that the published molecular support to link Turnagra with Ptilonorhynchidae was biased by the use of incorrect genetic data and weak analyses...
  25. pmc A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors
    Barbara Seidler
    Department of Internal Medicine 2, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 105:10137-42. 2008
    ....
  26. pmc An EAV-HP insertion in 5' Flanking region of SLCO1B3 causes blue eggshell in the chicken
    Zhepeng Wang
    National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding, and Reproduction of the Ministry of Agriculture, China Agricultural University, Beijing, China
    PLoS Genet 9:e1003183. 2013
    ....
  27. pmc cIRF-3, a new member of the interferon regulatory factor (IRF) family that is rapidly and transiently induced by dsRNA
    C E Grant
    Cancer Research Laboratories, Queen s University, Kingston, Ontario, Canada
    Nucleic Acids Res 23:2137-46. 1995
    ..Co-treatment of cells with cycloheximide results in superinduction of cIRF-3 mRNA. The structural and regulatory characteristics of cIRF-3 indicate that it is the first example of a non-mammalian IRF protein...
  28. pmc Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton
    I Sadler
    Department of Biology, University of Utah, Salt Lake City 84112
    J Cell Biol 119:1573-87. 1992
    ....
  29. pmc Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain
    Takayoshi Ubuka
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    Proc Natl Acad Sci U S A 102:3052-7. 2005
    ..Melatonin appears to act directly on GnIH neurons through its receptor to induce GnIH expression. This is the first demonstration, to our knowledge, of a direct action of melatonin on neuropeptide induction in any vertebrate class...
  30. pmc AHCYL1 is mediated by estrogen-induced ERK1/2 MAPK cell signaling and microRNA regulation to effect functional aspects of the avian oviduct
    Wooyoung Jeong
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea
    PLoS ONE 7:e49204. 2012
    ....
  31. pmc A critical role for Cadherin6B in regulating avian neural crest emigration
    E G Coles
    California Institute of Technology, Division of Biology, Pasadena, CA 91125, USA
    Dev Biol 312:533-44. 2007
    ..Our data reveal a novel role for Cad6B in controlling the proper timing of neural crest emigration and delamination from the neural tube of the avian embryo...
  32. ncbi TLR15 is unique to avian and reptilian lineages and recognizes a yeast-derived agonist
    Amy C Boyd
    The Jenner Institute, Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 189:4930-8. 2012
    ..Identification of yeast as an agonist source for TLR15 provides a functional framework for consideration of this TLR within the context of pattern recognition receptor evolution and may impact on the development of novel adjuvants...
  33. ncbi Chicken chromobox proteins: cDNA cloning of CHCB1, -2, -3 and their relation to W-heterochromatin
    K Yamaguchi
    Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan
    Exp Cell Res 242:303-14. 1998
    ....
  34. pmc The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair
    Ivan V Rosado
    MRC Laboratory of Molecular Biology, Hills Rd, Cambridge CB20QH, UK
    Nucleic Acids Res 37:4360-70. 2009
    ..Overall our results lead us to reappraise the role of helicase domain associated activities of FANCM with respect to the activation of the FA pathway, crosslink repair and in the resolution of recombination intermediates...
  35. pmc Two ZBP1 KH domains facilitate beta-actin mRNA localization, granule formation, and cytoskeletal attachment
    Kim L Farina
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 160:77-87. 2003
    ....
  36. ncbi An RCAS-TVA-based approach to designer mouse models
    Sandra Orsulic
    Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Mamm Genome 13:543-7. 2002
  37. ncbi Developmental changes in gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica) hypothalamo-hypophysial system
    T Ubuka
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    J Endocrinol 178:311-8. 2003
    ..These results suggest that GnIH begins its function around hatch and acts as a hypothalamic factor to regulate gonadotropin release in the bird...
  38. ncbi Association of a single-nucleotide substitution in TYRP1 with roux in Japanese quail (Coturnix japonica)
    N J Nadeau
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Anim Genet 38:609-13. 2007
    ..In addition, the Phe282 amino acid appears to be of functional significance, as it is highly conserved across the vertebrates. This is the first demonstration that TYRP1 has a role in pigmentation in birds...
  39. ncbi Gonadotropin-inhibitory peptide in song sparrows (Melospiza melodia) in different reproductive conditions, and in house sparrows (Passer domesticus) relative to chicken-gonadotropin-releasing hormone
    G E Bentley
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    J Neuroendocrinol 15:794-802. 2003
    ..In summary, GnIH has the potential to regulate gonadotropin release at more than one level, and its distribution is suggestive of multiple regulatory functions in the central nervous system...
  40. ncbi Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail
    Takayoshi Ubuka
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    Endocrinology 147:1187-94. 2006
    ..To our knowledge, GnIH is the first identified hypothalamic neuropeptide inhibiting reproductive function in any vertebrate class...
  41. ncbi Distribution of a novel avian gonadotropin-inhibitory hormone in the quail brain
    Kazuyoshi Ukena
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, 739 8521, Higashi Hiroshima, Japan
    Cell Tissue Res 312:73-9. 2003
    ..Thus, GnIH may participate not only in neuroendocrine functions, but also in behavioral and autonomic mechanisms...
  42. ncbi Characterization and application of oviductal epithelial cells in vitro in Gallus domesticus
    Jin Gyoung Jung
    Avicore Biotechnology Institute, Optifarm Solution Inc, Gyeonggi Do, Republic of Korea
    Biol Reprod 85:798-807. 2011
    ..05). In conclusion, these data demonstrate the potential of cultured OECs as a model system for providing a better understanding of the regulation of gene expression and for the production of an avian transgenic bioreactor...
  43. pmc Fatty acyl-CoA reductases of birds
    Janine Hellenbrand
    Special Botany, Institute for Biology I, RWTH Aachen University, Aachen, Germany
    BMC Biochem 12:64. 2011
    ..Alcohol-forming fatty acyl-CoA reductases (FAR) catalyze the reduction of activated acyl groups to fatty alcohols that can be esterified with acyl-CoA thioesters forming wax esters...
  44. ncbi The developmentally regulated avian Ch21 lipocalin is an extracellular fatty acid-binding protein
    F D Cancedda
    Centro di Biotecnologie Avanzate, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    J Biol Chem 271:20163-9. 1996
    ..We propose to rename the Ch21 protein as extracellular fatty acid-binding protein (Ex-FABP)...
  45. ncbi Development of a flexible and specific gene delivery system for production of murine tumor models
    G H Fisher
    Varmus Lab, NIH NCI DBS, 49 Convent Drive, Building 49, 4A56, Bethesda, Maryland 20892, USA
    Oncogene 18:5253-60. 1999
    ..We discuss the theoretical and practical aspects of using recombinant avian retroviruses with TVA transgenic mice to generate cancer models...
  46. ncbi Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade
    Jun K Takeuchi
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5, Takayama, Ikoma, Nara 630 0101, Japan
    Development 130:2729-39. 2003
    ....
  47. ncbi Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH)
    George E Bentley
    Department of Integrative Biology, University of California, Berkeley, 94720, USA
    Horm Behav 49:550-5. 2006
    ..These data demonstrate direct effects of GnIH upon reproductive physiology and behavior, possibly via separate actions on two forms of GnRH...
  48. pmc Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination
    Kazuhiko Yamamoto
    Department of Immunology and Molecular Genetics, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    Mol Cell Biol 25:34-43. 2005
    ..Thus, we propose that FancD2 promotes a subpathway of HR that normally mediates gene conversion by a mechanism that avoids crossing over and hence SCEs...
  49. ncbi Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain
    S Yoshida
    Departments of Biochemistry, Obstetrics and Gynecology, and Pathology, Nagoya University School of Medicine, Japan
    Eur J Biochem 267:4372-80. 2000
    ..No oligomer formation took place between the intact wild-type Ret and Bsg proteins. In conclusion, these data indicate that the N-terminal Ig-like domain is necessary and sufficient for oligomer formation by Bsg on the plasma membrane...
  50. ncbi Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis
    G V Mallo
    U 315 INSERM, Marseille, France
    Int J Cancer 74:35-44. 1997
    ..It was concluded that decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis...
  51. ncbi Multiple functions of fibroblast growth factor-8 (FGF-8) in chick eye development
    A Vogel-Höpker
    Division of Anatomy, Department of Surgery, University of California, San Diego, 92093 0604, USA
    Mech Dev 94:25-36. 2000
    ..This is apparent by the expression of a lens specific marker, L-Maf, and by morphological changes of lens cells. These results suggest that FGF-8 plays a role in the initiation and differentiation of neural retina and lens...
  52. ncbi A highly conserved RNA-binding protein for cytoplasmic mRNA localization in vertebrates
    J O Deshler
    Department of Cell Biology Harvard Medical School 240 Longwood Avenue, Boston, Massachusetts, 02115, USA
    Curr Biol 8:489-96. 1998
    ..We recently discovered Vera, a protein that binds specifically to the Vg1 localization element and is involved in the localization of Vg1 mRNA in Xenopus oocytes...
  53. pmc Differential expression of alpha 2 macroglobulin in response to dietylstilbestrol and in ovarian carcinomas in chickens
    Whasun Lim
    Department of Agricultural Biotechnology, Seoul National University, 599 Gwanak Ro, Gwanak Gu, Seoul 151 921, Korea
    Reprod Biol Endocrinol 9:137. 2011
    ..Therefore, we investigated estrogen regulation of A2M gene expression during development of the chicken oviduct, and its expression in normal and cancerous ovaries from chickens...
  54. ncbi Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis
    I Palmeirim
    Institut d Embryologie Cellulaire et Moleculaire du Centre National de la Recherche Scientifique et du College de France, Nogent sur Marne
    Cell 91:639-48. 1997
    ....
  55. ncbi ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family
    D L Falls
    Neurobiology Department, Harvard Medical School, Boston, Massachusetts 02115
    Cell 72:801-15. 1993
    ..Our data suggest that members of the ARIA protein family promote the formation and maintenance of chemical synapses and, furthermore, that receptor tyrosine kinases play important roles in this process...
  56. ncbi Expression of the avian-specific toll-like receptor 15 in chicken heterophils is mediated by gram-negative and gram-positive bacteria, but not TLR agonists
    Jessica R Nerren
    USDA ARS Southern Plains Agricultural Research Center, 2881 F and B Road, College Station, TX 77845, USA
    Vet Immunol Immunopathol 136:151-6. 2010
    ....
  57. ncbi WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo
    Y Kawakami
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 104:891-900. 2001
    ..Thus, three WNT signals mediated by beta-catenin control both limb initiation and AER induction in the vertebrate embryo...
  58. ncbi Gonadotropin-inhibitory hormone in Gambel's white-crowned sparrow (Zonotrichia leucophrys gambelii): cDNA identification, transcript localization and functional effects in laboratory and field experiments
    T Osugi
    Laboratory of Brain Science, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi hiroshima 739 8521, Japan
    J Endocrinol 182:33-42. 2004
    ..Thus, GnIH appears to be a modulator of gonadotropin release...
  59. ncbi Unique properties of the chicken TLR4/MD-2 complex: selective lipopolysaccharide activation of the MyD88-dependent pathway
    A Marijke Keestra
    Department of Infectious Diseases and Immunology, Utrecht University, Utrecht, The Netherlands
    J Immunol 181:4354-62. 2008
    ....
  60. pmc Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crest
    Ki Sook Park
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Development 137:2691-701. 2010
    ..Thus, the overall EMT of neural crest cells occurs via two distinct steps: a cadherin 6B and BMP signaling-mediated de-epithelialization, and a subsequent delamination through the basement membrane...
  61. ncbi Exogenous growth factors induce the production of ganglion cells at the retinal margin
    Andy J Fischer
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    Development 129:2283-91. 2002
    ..We conclude that the types of cells produced by progenitors at the retinal margin can be altered by exogenous growth factors and that normally the microenvironment imposes limitations on the types of neurons produced...
  62. ncbi Ultraviolet visual sensitivity in three avian lineages: paleognaths, parrots, and passerines
    Zachary Aidala
    Biopsychology and Behavioral Neuroscience Program, The Graduate Center of City University of New York, 365 Fifth Ave, New York, NY 10016 4309, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 198:495-510. 2012
    ..The results should stimulate future research into the functional parallels between the roles of visual signals and the genetic basis of visual sensitivity in birds and other taxa...
  63. ncbi Characterization of novel secreted and membrane proteins isolated by the signal sequence trap method
    M Shirozu
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    Genomics 37:273-80. 1996
    ..These results indicate that the SST method is effective and useful for the isolation of secreted and membrane proteins without knowledge of their functions...
  64. pmc Promoter hijack reveals pericentrin functions in mitosis and the DNA damage response
    Yifan Wang
    Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland
    Cell Cycle 12:635-46. 2013
    ..However, pericentrin disruption in Mcph1-/- cells abrogated centrosome hyperamplification after IR. We conclude that pericentrin controls genomic stability by both ensuring appropriate mitotic spindle activity and centrosome regulation...
  65. pmc CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A
    T Pushkarsky
    The Picower Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 98:6360-5. 2001
    ..These results suggest that HIV-1 entry depends on an interaction between virus-associated CyPA and CD147 on a target cell...
  66. ncbi Regionalized expression of ADAM13 during chicken embryonic development
    Juntang Lin
    Institute of Anatomy I, Friedrich Schiller University of Jena, Jena, Germany
    Dev Dyn 236:862-70. 2007
    ..Furthermore, ADAM13 mRNA was also detected in several tissues and organs, such as the somites and their derived muscles, the meninges surrounding the spinal cord, the dorsal aorta, the developing kidney, and several digestive organs...
  67. ncbi Molecular cloning and functional expression of gicerin, a novel cell adhesion molecule that binds to neurite outgrowth factor
    E Taira
    Department of Pharmacology, Osaka University School of Medicine, Japan
    Neuron 12:861-72. 1994
    ..Cells transfected stably with gicerin cDNA adhered to NOF and aggregated with each other, indicating that gicerin exhibits both heterophilic and homophilic adhesion activities...
  68. ncbi Localisation of the genomic sequence interval for the blue eggshell gene using an F2 resource population of Dongxiang chickens
    X T Wang
    China Agricultural University, Beijing, China
    Br Poult Sci 51:507-9. 2010
    ..3. Based on these results, we inferred that the O locus was located between the A and (tg)(n) loci, that is, Chr1:67,296,991-69,140,571, which is the first genomic sequence interval to be established for the blue eggshell gene...
  69. ncbi Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells
    I Duluc
    Institut National de la Sante et de la Recherche Medicale, Unité 381, Strasbourg, France
    J Cell Sci 110:1317-24. 1997
    ..They also indicate that the level of Cdx-1 and Cdx-2 homeobox gene expression is influenced by epithelial-mesenchymal cell interactions in the intestinal mucosa...
  70. ncbi Meat-type chickens have a higher efficiency of mitochondrial oxidative phosphorylation than laying-type chickens
    Masaaki Toyomizu
    Science of Biological Function, Life Science, Graduate School of Agricultural Science, Tohoku University, 1 1 Tsutsumidori Amamiyamachi, Aoba ku, Sendai 981 8555, Japan
    Comp Biochem Physiol A Mol Integr Physiol 159:75-81. 2011
    ..The current results regarding a higher efficiency of oxidative phosphorylation and UCP content may partially support the high feed efficiency of meat-type chickens...
  71. ncbi Ex-FABP, extracellular fatty acid binding protein, is a stress lipocalin expressed during chicken embryo development
    Fiorella Descalzi Cancedda
    Istituto Nazionale per la Ricerca sul Cancro, Centro Biotecnologie Avanzate, Genova, Italy
    Mol Cell Biochem 239:221-5. 2002
    ....
  72. pmc Inter-familial relationships of the shorebirds (Aves: Charadriiformes) based on nuclear DNA sequence data
    Per G P Ericson
    Department of Vertebrate Zoology and Molecular Systematics Laboratory, Swedish Museum of Natural History, Stockholm, Sweden
    BMC Evol Biol 3:16. 2003
    ..We also test earlier suggestions that bustards and sandgrouses may be nested with the charadriiforms. The data is analysed with methods based on the parsimony and maximum-likelihood criteria...
  73. ncbi Dietary high fluorine induces apoptosis and alters Bcl-2, Bax, and caspase-3 protein expression in the cecal tonsil lymphocytes of broilers
    Juan Liu
    Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya an 625014 Sichuan, China
    Biol Trace Elem Res 152:25-30. 2013
    ....
  74. ncbi Expression, regulation, and tissue distribution of the Ch21 protein during chicken embryogenesis
    B Dozin
    Laboratorio Differenziamento Cellulare, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    J Biol Chem 267:2979-85. 1992
    ..Thus quiescence per se is not the primary factor determining the expression of the protein...
  75. ncbi Inhibition of cell proliferation and induction of apoptosis by ExFABP gene targeting
    Eddi Di Marco
    Istituto Nazionale per la Ricerca sul Cancro, Centro Biotecnologie Avanzate, Genova, Italy
    J Cell Physiol 196:464-73. 2003
    ..We suggest that Ex-FABP acts as a constitutive survival protein and that its expression and activation are fundamental to protect chondrocytes from cell death...
  76. ncbi Ovalbumin-related gene Y protein bears carbohydrate chains of the ovomucoid type
    Junko Hirose
    Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Shiga, Japan
    Biosci Biotechnol Biochem 70:144-51. 2006
    ..We conclude that ovalbumin Y is a unique chimeric glycoprotein having an amino acid sequence similar to that of ovalbumin, but having a carbohydrate moiety similar to that of ovomucoid...
  77. pmc Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest
    Lisa A Taneyhill
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Development 134:1481-90. 2007
    ..These results are the first to describe a direct target of Snail2 repression in vivo and in the context of the EMT that characterizes neural crest development...
  78. pmc Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of chickens to infection by subgroup A avian sarcoma and leukosis viruses
    Daniel Elleder
    Department of Cellular and Viral Genetics, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague
    J Virol 78:13489-500. 2004
    ..Line 7(2) tva(r2) contains a 4-bp insertion in exon 1 that causes a change in the reading frame, which blocks expression of the Tva receptor...
  79. pmc Biochemical properties of gastrokine-1 purified from chicken gizzard smooth muscle
    Karim Hnia
    INSERM ERI 25 Muscle et Pathologies, Universite Montpellier 1, EA 4202, CHU Arnaud de Villeneuve, Montpellier, France
    PLoS ONE 3:e3854. 2008
    ..We focused on the F-actin interaction with gastrokine-1 and the potential role and function in smooth muscle contractile properties...
  80. ncbi Establishment of embryonic neuroepithelial cell lines exhibiting an epiplastic expression pattern of region specific markers
    Jeannette Nardelli
    INSERM U368, Ecole Normale Superieure, Paris, France
    J Neurosci Res 73:737-52. 2003
    ..With respect to these as yet unique properties, b2T cells constitute an original alternative tool to in vivo models for the analysis of molecular pathways involved in the patterning of the neural tube...
  81. ncbi The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription
    Claudia Bagutti
    Friedrich Miescher Institute, Novartis Forschungsstiftung, PO Box 2543, CH 4002 Basel, Switzerland
    J Cell Sci 116:2957-66. 2003
    ....
  82. pmc The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure
    Jo Ellen Feugate
    Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA
    J Cell Biol 156:161-72. 2002
    ....
  83. ncbi Teneurin 2 is expressed by the neurons of the thalamofugal visual system in situ and promotes homophilic cell-cell adhesion in vitro
    Beatrix P Rubin
    Friedrich Miescher Institute, Novartis Research Foundation, PO Box 2543, CH 4002 Basel, Switzerland
    Development 129:4697-705. 2002
    ..These observations indicate that the homophilic binding of teneurin 2 may play a role in the development of specific neuronal circuits in the developing visual system...
  84. ncbi Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation
    Guojun Sheng
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Cell 115:603-13. 2003
    ..These results reveal that neural induction requires cessation of mesoderm formation at the midline in addition to the decision between epidermis and neural plate...
  85. ncbi Boundary formation and compartition in the avian diencephalon
    C W Larsen
    Medical Research Council Centre for Developmental Neurobiology, King's College London, London SE1 1UL, England
    J Neurosci 21:4699-711. 2001
    ..Our results suggest that the diencephalon does not have an overt segmental pattern...
  86. ncbi Insulin and fibroblast growth factor 2 activate a neurogenic program in Müller glia of the chicken retina
    Andy J Fischer
    Department of Biological Structure, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 22:9387-98. 2002
    ..These findings imply that exogenous growth factors might be used to stimulate endogenous glial cells to regenerate neurons in the CNS...
  87. ncbi Gallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes
    S S Harwig
    Department of Medicine, UCLA Center for the Health Sciences 90024
    FEBS Lett 342:281-5. 1994
    ..The 9 invariant residues (6 cysteines, 2 glycines and 1 proline) common to avian gallinacins and bovine beta-defensins are likely to constitute the essential primary structural motif of this ancient family of host-defense peptides...
  88. pmc Pair bonding in the female zebra finch: a potential role for the nucleus taeniae
    L A Svec
    Neuroscience Program, 108 Giltner Hall, Michigan State University, East Lansing, MI 48824, USA
    Neuroscience 160:275-83. 2009
    ..The results indicate that the nucleus taeniae may play some role in the maintenance of pair bonds in this species. Additionally, females may provide some signal to influence elements of the behavior of males...
  89. ncbi All four members of the Ten-m/Odz family of transmembrane proteins form dimers
    Kang Feng
    Department of Experimental Pathology, Lund University, S 221 85 Lund, Sweden
    J Biol Chem 277:26128-35. 2002
    ....
  90. ncbi Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors
    David F Chang
    The Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 4:107-18. 2003
    ....
  91. ncbi To the 30-nm chromatin fiber and beyond
    Nicholas L Adkins
    Department of Biological Sciences, College of Science, Marshall University, 1 John Marshall Drive, Huntington, WV 25701, USA
    Biochim Biophys Acta 1677:12-23. 2004
    ..The major points of emphasis of this review will assess the structure, function and recently documented exchanges amongst various members of the CAP family...
  92. ncbi A role for the hypoblast (AVE) in the initiation of neural induction, independent of its ability to position the primitive streak
    Amanda Albazerchi
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Dev Biol 301:489-503. 2007
    ..Interestingly, FGF and retinoids, generally considered as caudalizing factors, are shown here to play a role in the induction of a transient "pre-neural/pre-forebrain" state...
  93. pmc Gallinacin-3, an inducible epithelial beta-defensin in the chicken
    C Zhao
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    Infect Immun 69:2684-91. 2001
    ....
  94. ncbi Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken
    David J Lynn
    Education and Research Centre, St Vincent s University Hospital, 4, Dublin, Ireland
    Immunogenetics 56:170-7. 2004
    ..An evolutionary analysis of the gallinacin family has detected sites-primarily in the mature AMP-that are under positive selection in these molecules. The functional implications of these results are discussed...
  95. ncbi Identification of chick frizzled-10 expressed in the developing limb and the central nervous system
    Y Kawakami
    Department of Molecular Biology, Kawasaki Medical School, Kurashiki, Japan
    Mech Dev 91:375-8. 2000
    ..Fz-10 is also expressed in the feather bud and branchial arch. Implantation of Sonic hedgehog (Shh)-expressing cells into the anterior margin of the limb bud resulted in the induction of Fz-10 expression in anterior-dorsal mesenchyme...
  96. ncbi Effects of age, egg-laying activity, and Salmonella-inoculation on the expressions of gallinacin mRNA in the vagina of the hen oviduct
    Yukinori Yoshimura
    Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima, Japan
    J Reprod Dev 52:211-8. 2006
    ..Also, synthesis of these antimicrobial peptides in the vagina may increase in response to SE and LPS to eliminate SE bacteria...
  97. ncbi Müller glia are a potential source of neural regeneration in the postnatal chicken retina
    A J Fischer
    Department of Biological Structure, University of Washington School of Medicine, Health Science Center, PO Box 357420, Seattle, Washington 98195, USA
    Nat Neurosci 4:247-52. 2001
    ..We propose that, in response to damage, Müller glia in the retina are a potential source of neural regeneration...
  98. ncbi Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1
    Stefan Huttelmaier
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nature 438:512-5. 2005
    ..These sequential events provide both temporal and spatial control over beta-actin mRNA translation, which is important for cell migration and neurite outgrowth...
  99. pmc Characterization of a beta-actin mRNA zipcode-binding protein
    A F Ross
    Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655, USA
    Mol Cell Biol 17:2158-65. 1997
    ..These data suggest that the 68-kDa ZBP-1 we have isolated and cloned is an RNA-binding protein that functions within a complex to localize beta-actin mRNA...
  100. pmc Expression patterns of Wnt genes during development of an anterior part of the chicken eye
    Valentina M Fokina
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 1072, USA
    Dev Dyn 235:496-505. 2006
    ..These data suggest that Wnt signaling might play important roles in anterior eye development...

Research Grants47

  1. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2009
    ....
  2. Metabolic Regulation of Reproduction
    GREGORY FRALEY; Fiscal Year: 2006
    ..It is hoped that this basic knowledge will lead to a better understanding of disorders of reproduction that are associated with diabetes and thus provide an enlightened path towards their treatment. ..
  3. Completion of a Large Insertional Screen in Zebrafish
    Nancy Hopkins; Fiscal Year: 2005
    ....
  4. Cdx in GI Differentiation and Transdifferentiation
    Debra Silberg; Fiscal Year: 2005
    ..In summary, the overall goal of this project is to elucidate the biological roles of Cdxl and Cdx2 in intestinal metaplasia and the molecular mechanisms of the transdifferentiation program induced by Cdxl and Cdx2. ..
  5. Analysis of the SARS Virus S glycoproteins
    Paul Bates; Fiscal Year: 2005
    ....
  6. CD4+ memory T cell recruitment by cyclophilin
    Michael Bukrinsky; Fiscal Year: 2004
    ..Therefore, the R03 mechanism appears highly appropriate. If proven, this hypothesis will serve as a foundation for a new research program, which might suggest novel approaches to treatment of HIV-1 infection. ..
  7. Understanding cell biology of Delta-Notch interactions
    GERALDINE WEINMASTER; Fiscal Year: 2006
    ....
  8. The Role of Vpr in HIV-1 Nuclear Translocation
    Michael Bukrinsky; Fiscal Year: 2006
    ..These results will be significant, because they are expected to facilitate discovery of agents that would inhibit Vpr activity and thus attenuate HIV replication. ..
  9. REGULATION OF INTESTINE-SPECIFIC GENE TRANSCRIPTION
    Eunran Suh; Fiscal Year: 2006
    ..abstract_text> ..
  10. Zebrafish in Comparative Context: A Symposium
    Thomas Schilling; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  11. WT1 Expression in Patients with MDS Treated with ATG an*
    H Deeg; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  12. Genetic Control of Schwann Cell Differentiation
    JOHN RUTLEDGE BERMINGHAM; Fiscal Year: 2011
    ..By understanding how the Lgi4 protein controls Schwann cell development, we will establish new avenues for the treatment of myelin disorders and nerve injury. ..
  13. Understanding Head Development: A Segmental Groundplan of Vertebrates
    Thomas Schilling; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  14. Cell Death and Clonal Survival in Myelodysplastic Syndr*
    H Deeg; Fiscal Year: 2008
    ..To achieve these objectives, we must better understand the underlying mechanisms of MDS and thereby identify ways by which the disease process can be arrested, progression prevented, and the disease hopefully be cured. ..
  15. Therapeutics targeting cathepsin-activated viral entry
    Paul Bates; Fiscal Year: 2008
    ..In conclusion, the proposed work will produce candidate molecules for treatment of infection by viruses such as Ebola, SARS CoV and Hendra. [unreadable] [unreadable] [unreadable]..
  16. Oxadaizols: Rationally designed compounds targeting HIV nuclear importation
    Michael Bukrinsky; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. Analysis of Therapeutic Adipose Tissue Remodeling
    JAMES GRANNEMAN; Fiscal Year: 2004
    ..2) To examine adipose tissue cellular dynamics during therapeutic remodeling induced by agonist activation of beta3-adrenergic receptors and PPAR-gamma. ..
  18. FUNCTIONAL ANALYSIS OF RSV ENVELOPE GLYCOPROTEIN
    Paul Bates; Fiscal Year: 2002
    ..3) Determine the consequences of the Tva/EnvA interaction: cooperative effects on conformational changes, characterization of activated EnvA, and analysis of the effects of peptides to conserved regions of TM. ..
  19. NOTCH SIGNALING IN MAMMALIAN CELLS
    GERALDINE WEINMASTER; Fiscal Year: 2002
    ..Together the experiments proposed in this grant will provide new information on the structure/function requirements of Notch-ligand interactions and thereby extend our present understanding of mammalian Notch signaling. ..
  20. BETA 1 AND BETA 3 ADRENORECEPTORS
    JAMES GRANNEMAN; Fiscal Year: 2001
    ..Aim 2. To further characterize the differential signaling properties of beta1- beta3-AR and to examine the cellular and molecular basis. Specific Aim 3. To examine the molecular pharmacology of beta3-AR-selective agonists. ..
  21. LENTIVIRUS VECTORS FOR CYSTIC FIBROSIS GENE THERAPY
    Paul Bates; Fiscal Year: 2002
    ..abstract_text> ..
  22. INVESTIGATING A ROLE FOR NOTCH SIGNALING IN ANGIOGENESIS
    GERALDINE WEINMASTER; Fiscal Year: 2001
    ..abstract_text> ..
  23. REGULATION OF CDX GENE EXPRESSION IN COLON CANCER
    Eunran Suh; Fiscal Year: 2002
    ..This will provide the basis for understanding the network of cellular pathways that control these important cell specific transcription factors and how they are altered in neoplasia. ..
  24. BIOLOGICAL FUNCTION OF XRCC2 IN RECOMBINATIONAL REPAIR
    Nan Liu; Fiscal Year: 2003
    ..This study will lead to a better understanding of the role of XRCC2 in mammalian HRR and the importance of this pathway in maintaining chromosomal stability. ..
  25. NUCLEAR TRANSLOCATION OF HIV 1 GENOME AS A DRUG TARGET
    Michael Bukrinsky; Fiscal Year: 2004
    ..Upon completion, these studies are expected to define potent anti-HIV compounds working through a novel mechanism different from that of any other currently used drug. ..
  26. Molecular Mechanisms Underlying Barrett's Esophagus
    Debra Silberg; Fiscal Year: 2003
    ....
  27. Imaging Technology for HIV Nuclear Import Inhibitors
    Michael Bukrinsky; Fiscal Year: 2003
    ..The imaging technology will greatly augment the value of the project by adding a superior method for analyzing the activity of the drugs. ..
  28. NOVEL THERAPEUTIC STRATEGIES IN MYELODYSPLASTIC SYNDROME
    H Deeg; Fiscal Year: 2003
    ..Optimization of therapy, in turn, should reduce morbidity and mortality associated with MDS and improve the quality of life of patients with MDS. ..
  29. GENETIC ANALYSIS OF NUCLEOTIDE EXCISION REPAIR
    LAWRENCE THOMPSON; Fiscal Year: 2002
    ..These mechanistic insights will guide future structural studies on ERCC2. ..
  30. FANCONI ANEMIA GENE PATHWAY IN RADIATION RESPONSES
    LAWRENCE THOMPSON; Fiscal Year: 2004
    ..The results of these studies will lead to more specific models of the nature of the FA protein "pathway" and its quantitative contributions to multiple biological effects associated with IR-mediated oxidative damage. ..
  31. HIV Impairs Reverse Cholesterol Transport
    Michael Bukrinsky; Fiscal Year: 2006
    ..These studies are expected to yield sufficient information upon which to base a well-planned and rigorous series of further investigations. [unreadable] [unreadable]..
  32. Homologous Recombination & Human Cell Radiosensitivity
    LAWRENCE THOMPSON; Fiscal Year: 2009
    ..These integrated studies may lead to a more rational basis for cancer radiotherapy and bring'insights into how HRR prevents the initiation of carcihogenesis by endogenous processes and exogenous agents. ..
  33. A flexible somatic and sporadic mouse model for pancreatic ductal adenocarcinoma
    Brian Lewis; Fiscal Year: 2007
    ..Such an advance would benefit public health by reducing the mortality associated with this disease. [unreadable] [unreadable] [unreadable]..
  34. Leukocyte recruitment by cyclophilinc-CD147 interaction
    Michael Bukrinsky; Fiscal Year: 2005
    ..This exploratory proposal is fully consistent with the goals of this PA as it extends our previous discovery toward new directions related to regulation of inflammatory responses. ..
  35. Molecular mediators of metastasis in hepatocellular carcinoma
    Brian C Lewis; Fiscal Year: 2010
    ..abstract_text> ..
  36. Developing a mouse model to study Notch furin processing
    GERALDINE WEINMASTER; Fiscal Year: 2002
    ....
  37. Molecular Mechanisms in Vertebrate Midbrain Development
    Seema Agarwala; Fiscal Year: 2010
    ..Understanding the specification of midbrain neurons is also crucial to the development of stem cell based therapeutic strategies to combat Parkinson's disease and stroke. ..
  38. Transgenic Chickens using Primordial Germ Cells
    Marie Cecile van de Lavoir; Fiscal Year: 2007
    ..These transfected cell popupations will then be trafficked through the germline to obtain a flock of transgenic chickens. [unreadable] [unreadable]..
  39. Function of CMF1 Protein During Avian Myogenesis
    MARY DEES; Fiscal Year: 2006
    ..Novel approaches to identify CMF1 related proteins are Included in this proposal. The overall goal is to elucidate novel mechanisms that regulate myogenesis and of developmental processes in general. ..
  40. Primordial germ cells from chicken embryonic stem cells
    Marie Cecile van de Lavoir; Fiscal Year: 2005
    ..To obtain robust levels of germline transmission this application proposes to derive PGCs from embryonic stem cells and to colonize the gonad with in vitro derived PGCs. ..
  41. Production of Polyclonal Antibodies in Eggs
    Marie Cecile van de Lavoir; Fiscal Year: 2003
    ..abstract_text> ..
  42. REGULATION OF B CELL DEVELOPMENT AND SIGNALING BY BTK
    David Rawlings; Fiscal Year: 2008
    ....
  43. Lentiviral Gene Therapy for Wiskott-Aldrich Syndrome
    David Rawlings; Fiscal Year: 2007
    ..abstract_text> ..
  44. Lentiviral Gene Therapy of X-linked Agammaglobulinemia
    David Rawlings; Fiscal Year: 2008
    ..Overcoming these technical challenges should also provide insight for development of gene therapy in congenital diseases that lack a selective advantage. ..
  45. CELLULAR AND MOLECULAR STUDIES OF VESTIBULAR HAIR CELLS
    MANNING CORREIA; Fiscal Year: 2007
    ..The two specific aims of this project are linked in that one drives studies of the the effector pKir2.1 and the second directs studies the msucarinic receptors in the pathway proposed above. ..