apolipoproteins

Summary

Summary: The protein components of lipoproteins which remain after the lipids to which the proteins are bound have been removed. They play an important role in lipid transport and metabolism.

Top Publications

  1. pmc APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, USA
    J Am Soc Nephrol 22:2129-37. 2011
  2. pmc Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene
    Shay Tzur
    Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Hum Genet 128:345-50. 2010
  3. ncbi The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese
    Toru Nabika
    Department of Laboratory Medicine, Shimane Medical University, 693 8501, Izumo, Japan
    Atherosclerosis 165:201-4. 2002
  4. doi Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study
    Matthew J McQueen
    Population Health Research Institute and McMaster University, Hamilton, ON, Canada
    Lancet 372:224-33. 2008
  5. ncbi Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women
    Paul M Ridker
    Donald W Reynolds Center for Cardiovascular Research, LeDucq Center for Molecular and Genetic Epidemiology, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 294:326-33. 2005
  6. ncbi Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels
    Len A Pennacchio
    Genome Sciences Department, MS 84 171, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Hum Mol Genet 11:3031-8. 2002
  7. pmc APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy
    Natalia Papeta
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Am Soc Nephrol 22:1991-6. 2011
  8. pmc Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo
    William R Lagor
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 29:40-6. 2009
  9. ncbi Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren
    Kazue Endo
    Department of Medical Science and Welfare, Institute of Community Medicine, University of Tsukuba, Tennoudai 1 1 1, Tsukuba shi, Ibaraki ken 305 8575, Japan
    Hum Genet 111:570-2. 2002
  10. ncbi Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis
    Christian Wolfrum
    The Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Med 11:418-22. 2005

Detail Information

Publications305 found, 100 shown here

  1. pmc APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy
    Jeffrey B Kopp
    Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland, USA
    J Am Soc Nephrol 22:2129-37. 2011
    ..These data add to the evidence base required to determine whether genetic testing for APOL1 has a use in clinical practice...
  2. pmc Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene
    Shay Tzur
    Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Hum Genet 128:345-50. 2010
    ....
  3. ncbi The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese
    Toru Nabika
    Department of Laboratory Medicine, Shimane Medical University, 693 8501, Izumo, Japan
    Atherosclerosis 165:201-4. 2002
    ..0001). This result indicates that polymorphism in the apoAV gene influence serum TG in populations of different ethnicities...
  4. doi Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study
    Matthew J McQueen
    Population Health Research Institute and McMaster University, Hamilton, ON, Canada
    Lancet 372:224-33. 2008
    Whether lipoproteins are better markers than lipids and lipoproteins for coronary heart disease is widely debated. Our aim was to compare the apolipoproteins and cholesterol as indices for risk of acute myocardial infarction.
  5. ncbi Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women
    Paul M Ridker
    Donald W Reynolds Center for Cardiovascular Research, LeDucq Center for Molecular and Genetic Epidemiology, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 294:326-33. 2005
    ..for cardiovascular risk detection are controversial with regard to the clinical utility of different lipid measures, non-high-density lipoprotein cholesterol (non-HDL-C), lipid ratios, apolipoproteins, and C-reactive protein (CRP).
  6. ncbi Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels
    Len A Pennacchio
    Genome Sciences Department, MS 84 171, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Hum Mol Genet 11:3031-8. 2002
    ..Together, the APOA5*2 and APOA5*3 haplotypes are found in 25-50% of African-Americans, Hispanics and Caucasians and support the contribution of common human variation to quantitative phenotypes in the general population...
  7. pmc APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy
    Natalia Papeta
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Am Soc Nephrol 22:1991-6. 2011
    ..These data further support the strong association of genetic variants in APOL1 with susceptibility to FSGS and HIVAN among African Americans...
  8. pmc Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo
    William R Lagor
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 29:40-6. 2009
    ..It is also known as lipid transfer inhibitor protein (LTIP) based on its ability to inhibit lipid transfer between lipoproteins ex vivo. We sought to investigate the role of ApoF in HDL metabolism...
  9. ncbi Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren
    Kazue Endo
    Department of Medical Science and Welfare, Institute of Community Medicine, University of Tsukuba, Tennoudai 1 1 1, Tsukuba shi, Ibaraki ken 305 8575, Japan
    Hum Genet 111:570-2. 2002
    ..4 (1.0-6.2). Our data suggested that the T/C promoter region polymorphism of the APOA5 gene appears to be a genetic risk factor for hypertriglyceridemia in Japanese children...
  10. ncbi Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis
    Christian Wolfrum
    The Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Med 11:418-22. 2005
    ..Accordingly, apoM-deficient mice lacked prebeta-HDL, a subclass of lipid-poor apolipoproteins that serves as a key acceptor of peripheral cellular cholesterol...
  11. pmc Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome
    Iain Moore
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, United Kingdom
    Blood 115:379-87. 2010
    ..In 5 patients mutations were identified: 1 in CFH, 1 in CFI, 1 in CD46, and 2 in C3. The latter observation emphasizes that multiple concurrent factors may be necessary in individual patients for disease manifestation...
  12. pmc The APOL1 gene and allograft survival after kidney transplantation
    A M Reeves-Daniel
    Department of Internal Medicine, Section on Nephrology, Winston Salem, North Carolina, USA
    Am J Transplant 11:1025-30. 2011
    ..If replicated, APOL1 genotyping could improve the donor selection process and maximize long-term renal allograft survival...
  13. ncbi A novel human apolipoprotein (apoM)
    N Xu
    Department of Clinical Chemistry, University of Lund, University Hospital, Malmo, S 20502 Malmo, Sweden
    J Biol Chem 274:31286-90. 1999
    ..This finding suggests that apoM is linked to the single phospholipid layer of lipoproteins with a hydrophobic signal anchor. In conclusion, a novel human apolipoprotein, the function of which remains to be determined, is described...
  14. ncbi Identification of novel members of the serum amyloid A protein superfamily as constitutive apolipoproteins of high density lipoprotein
    A S Whitehead
    Department of Immunology, Children s Hospital, Boston, Massachusetts
    J Biol Chem 267:3862-7. 1992
    ..was partially sequenced, and immunochemical analyses indicated that it constitutes a distinct subclass of apolipoproteins within the SAA superfamily. A C-SAA cDNA clone was isolated from a human liver library and sequenced...
  15. ncbi Human apolipoprotein E. The complete amino acid sequence
    S C Rall
    J Biol Chem 257:4171-8. 1982
  16. pmc Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans
    Jon C Gonzales
    Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, UCSD, La Jolla, California 92093 0687, USA
    J Clin Invest 123:2742-51. 2013
    ..We sought to identify the relevant apolipoproteins on TRLs that mediate binding to SDC1 and determine their clinical relevance...
  17. ncbi Hyperglycemia down-regulates apolipoprotein M expression in vivo and in vitro
    Xiaoying Zhang
    Comprehensive Laboratory, The Third Affiliated Hospital, Suzhou University, Changzhou 213003, China
    Biochim Biophys Acta 1771:879-82. 2007
    ..However, in HepG2 cells both glucose and insulin markedly inhibited apoM expression these effects were additive. Thus, the possible effects of insulin in vivo seem to be mediated indirectly...
  18. ncbi Down-regulation of apolipoprotein M expression is mediated by phosphatidylinositol 3-kinase in HepG2 cells
    Ning Xu
    Section of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lunds University, S 221 85 Lund, Sweden
    Biochim Biophys Acta 1761:256-60. 2006
    ..In conclusion, this study shows that apoM expression is regulated by PI3-kinase in HepG2-cells...
  19. doi Fasting and nonfasting lipid levels: influence of normal food intake on lipids, lipoproteins, apolipoproteins, and cardiovascular risk prediction
    Anne Langsted
    Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark
    Circulation 118:2047-56. 2008
    ..Lipid profiles are usually measured after fasting. We tested the hypotheses that these levels change only minimally in response to normal food intake and that nonfasting levels predict cardiovascular events...
  20. doi Apolipoproteins: metabolic role and clinical biochemistry applications
    Marek H Dominiczak
    NHS Greater Glasgow and Clyde Clinical Biochemistry Service and College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 0YN, UK
    Ann Clin Biochem 48:498-515. 2011
    Lipoprotein metabolism is dependent on apolipoproteins, multifunctional proteins that serve as templates for the assembly of lipoprotein particles, maintain their structure and direct their metabolism through binding to membrane ..
  21. doi Apolipoprotein M promoter polymorphisms alter promoter activity and confer the susceptibility to the development of type 1 diabetes
    Xiaopan Wu
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, 5 Dongdan 3 Tiao, Beijing 100005, PR China
    Clin Biochem 42:17-21. 2009
    ..Apolipoprotein M plays an important role in the formation of prebeta-HDL and cholesterol efflux to HDL. In the present study, we investigate the potential association between the ApoM promoter polymorphisms and type 1 diabetes...
  22. ncbi Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration
    H N van der Vliet
    Department of Experimental Hepatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    J Biol Chem 276:44512-20. 2001
    ..The protein encoded by this gene had appreciable homology with apolipoproteins A-I and A-IV...
  23. pmc The APOL1 genotype of African American kidney transplant recipients does not impact 5-year allograft survival
    B T Lee
    Department of Medicine, Division of Nephrology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 12:1924-8. 2012
    ..Thus, we were able to conclude that APOL1 genotypes do not increase risk of allograft loss after kidney transplantations, and carrying 2 APOL1 risk alleles should not be an impediment to transplantation...
  24. pmc MYH9 and APOL1 are both associated with sickle cell disease nephropathy
    Allison E Ashley-Koch
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA allison ashleykoch duke edu
    Br J Haematol 155:386-94. 2011
    ..Our data provide insight into the pathobiology of renal dysfunction in SCD, suggesting that MYH9 and APOL1 are both associated with risk...
  25. doi The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
    J Biol Chem 283:18765-72. 2008
    Lipoproteins consist of lipids solubilized by apolipoproteins. The lipid-binding structural motifs of apolipoproteins include amphipathic alpha-helixes and beta-sheets...
  26. pmc APOL1 localization in normal kidney and nondiabetic kidney disease
    Sethu M Madhavan
    Department of Medicine and the Rammel kamp Center for Education and Research, Metro Health System Campus, Cleveland, Ohio, USA
    J Am Soc Nephrol 22:2119-28. 2011
    ..Comparing the renal distribution of APOL1 in nondiabetic kidney disease to normal kidney suggests that a previously unrecognized arteriopathy may contribute to disease pathogenesis in patients of African ancestry...
  27. pmc Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7
    Nobukiyo Tanaka
    Department of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    J Lipid Res 51:2591-9. 2010
    ..experiments demonstrated that endogenous ABCA7 predominantly resides on the cell surface and that the apolipoproteins increase the surface ABCA7...
  28. doi Molecular basis of C-reactive protein binding and modulation of complement activation by factor H-related protein 4
    Mario Hebecker
    Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Jena, Germany
    Mol Immunol 47:1347-55. 2010
    ..In summary, these data reveal the molecular basis of the specific interaction of CFHR4 with native CRP and suggest a role for CFHR4 in enhancing opsonization via CRP binding...
  29. ncbi Newly identified apolipoprotein AV gene predisposes to high plasma triglycerides in familial combined hyperlipidemia
    Josep Ribalta
    Unitat de Recerca de Lipids i Arteriosclerosi, Institut de Recerca en Ciències de la Salut, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Sant Llorenc 21, 43201 Reus, Spain
    Clin Chem 48:1597-600. 2002
  30. ncbi Plasma lipoproteins: apolipoprotein structure and function
    R W Mahley
    J Lipid Res 25:1277-94. 1984
    ..The major apolipoproteins include apoE, apoB, apoA-I, apoA-II, apoA-IV, apoC-I, apoC-II, and apoC-III...
  31. ncbi Apolipoproteins modulate the inflammatory response to lipopolysaccharide
    Jimmy F P Berbee
    TNO Quality of Life, Department of Biomedical Research, Gaubius Laboratory, Leiden, The Netherlands
    J Endotoxin Res 11:97-103. 2005
    ..loss of apoCI, and an increase in apoE-containing HDL, as related to the effect of LPS on a wide range of apolipoproteins, plasma enzymes, lipid transfer factors, and receptors that are involved in HDL metabolism...
  32. ncbi Isolation and characterization of human apolipoprotein M-containing lipoproteins
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospital, University of Copenhagen, Copenhagen DK 2100, Denmark
    J Lipid Res 47:1833-43. 2006
    ..Nevertheless, apoM designates a subpopulation of HDL that protects LDL against oxidation and stimulates cholesterol efflux more efficiently than HDL lacking apoM...
  33. ncbi Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis
    Philip J Barter
    Hanson Institute and the Department of Cardiology, Royal Adelaide Hospital, Adelaide, Australia
    Arterioscler Thromb Vasc Biol 23:160-7. 2003
    ..Thus, it seems important and timely to test the hypothesis in randomized trials of humans that pharmacological inhibition of CETP retards the development of atherosclerosis...
  34. ncbi Effect of apolipoprotein M on high density lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knock-out mice
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    J Biol Chem 283:1839-47. 2008
    ..The effect of apoM on atherosclerosis may be facilitated by enzymatic modulation of plasma HDL particles, increased cholesterol efflux from foam cells, and an antioxidative effect of apoM-containing HDL...
  35. pmc Population-based risk assessment of APOL1 on renal disease
    David J Friedman
    Renal Division, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Am Soc Nephrol 22:2098-105. 2011
    ..In contrast, African Americans without the risk genotype and European Americans appear to have similar risk for developing nondiabetic CKD...
  36. doi The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans
    Barry I Freedman
    Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Am Soc Nephrol 21:1422-6. 2010
    ..This association likely explains racial disparities in nondiabetic nephropathy as a result of the high prevalence of risk alleles in individuals of African ancestry...
  37. ncbi ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins
    Ashley M Vaughan
    Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, Washington 98195 6426, USA
    J Biol Chem 280:30150-7. 2005
    ..These studies show that ABCG1 redistributes cholesterol to cell-surface domains where it becomes accessible for removal by HDL, consistent with a direct role of ABCG1 in cellular cholesterol transport...
  38. ncbi Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes
    David Perez-Morga
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium
    Science 309:469-72. 2005
    ..In Trypanosoma brucei, apolipoprotein L-I was targeted to the lysosomal membrane and triggered depolarization of this membrane, continuous influx of chloride, and subsequent osmotic swelling of the lysosome until the trypanosome lysed...
  39. ncbi Apolipoprotein J: structure and tissue distribution
    H V de Silva
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Ohio 45267 0575
    Biochemistry 29:5380-9. 1990
    ..ApoJ is unique among previously characterized human apolipoproteins in its structure and tissue distribution.
  40. pmc A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9
    Giulio Genovese
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 78:698-704. 2010
    ..Further studies will be required to establish which variants are causally related to kidney disease, what mutations caused the selective sweep, and to ultimately determine if these are the same...
  41. ncbi A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins
    B A Corbett
    Department of Psychiatry and Behavioral Sciences, University of California at Davis, Sacramento, CA 95817, USA
    Mol Psychiatry 12:292-306. 2007
    ....
  42. doi Low-grade inflammation, and dysfunction of high-density lipoprotein and its apolipoproteins as a major driver of cardiometabolic risk
    Altan Onat
    Turkish Society of Cardiology, Istanbul University, Istanbul 34098, Turkey
    Metabolism 60:499-512. 2011
    ..The great impact in public health of the dysfunction of protective serum proteins requires individual clinical recognition, appropriate preventive measures, and delineation of management, including with anti-inflammatory drugs...
  43. ncbi C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    P M Ridker
    Center for Cardiovascular Disease Prevention, and Division of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 342:836-43. 2000
    ..Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events...
  44. ncbi Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids
    Bradley E Aouizerat
    Department of Physiological Nursing, University of California San Francisco, San Francisco, CA 94143, USA
    J Lipid Res 44:1167-73. 2003
    ..These findings indicate that APOAV is an important determinant of plasma TG and lipoprotein cholesterol, and is potentially a risk factor for cardiovascular disease...
  45. ncbi An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing
    L A Pennacchio
    Genome Sciences Department, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 294:169-73. 2001
    ..These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease...
  46. ncbi Apolipoprotein AV accelerates plasma hydrolysis of triglyceride-rich lipoproteins by interaction with proteoglycan-bound lipoprotein lipase
    Martin Merkel
    Department of Internal Medicine IUniversity Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    J Biol Chem 280:21553-60. 2005
    ..A direct interaction between LPL and apoAV was found by ligand blotting. It is proposed, that apoAV reduces triglyceride levels by guiding VLDL and chylomicrons to proteoglycan-bound LPL for lipolysis...
  47. pmc Genetic variation in APOL1 associates with younger age at hemodialysis initiation
    Zahra Kanji
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Soc Nephrol 22:2091-7. 2011
    ..In conclusion, genetic variations in APOL1 identify African Americans that initiate chronic hemodialysis at a younger age. Early interventions to prevent progression of kidney disease may benefit this high-risk population...
  48. ncbi Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivo
    Ning Xu
    Department of Clinical Chemistry, Institute of Laboratory Medicine, University Hospital of Lund, S 221 85 Lund, Sweden
    Biochem Biophys Res Commun 321:916-21. 2004
    ..We conclude that both leptin and leptin-receptor are essential for the apoM expression, indicating that leptin is physiologically regulating apoM synthesis in vivo...
  49. ncbi Genetic variation in apolipoprotein D and Alzheimer's disease
    Seppo Helisalmi
    Dept of Neuroscience and Neurology, University Hospital and University of Kuopio, Kuopio, Finland
    J Neurol 251:951-7. 2004
    ..Each method suggested that the -352G allele frequency is higher for EOAD in the eastern Finnish population...
  50. doi Serendipitous fatty acid binding reveals the structural determinants for ligand recognition in apolipoprotein M
    Madhumati Sevvana
    Lehrstuhl für Biotechnik, Department of Biology, Friedrich Alexander University Erlangen Nuremberg, Im IZMP, Henkestr 91, D 91052 Erlangen, Germany
    J Mol Biol 393:920-36. 2009
    ....
  51. doi Plasma apolipoprotein M is reduced in metabolic syndrome but does not predict intima media thickness
    Robin P F Dullaart
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Clin Chim Acta 406:129-33. 2009
    ..Plasma apoM is decreased in obese mouse models. We hypothesized that plasma apoM is lower in metabolic syndrome (MetS) subjects, and determined whether intima media thickness (IMT) is associated with apoM...
  52. ncbi Immunolocalization of apolipoproteins in aortic atherosclerosis in American youths and young adults: findings from the PDAY study
    Y Ishikawa
    Department of Pathology, Toho University School of Medicine, 5-21-16 Omori-nishi, Ohta-ku, Tokyo 143-8540, Japan
    Atherosclerosis 158:215-25. 2001
    The immunohistochemical distribution of apolipoproteins in the abdominal aortas of 142 men, 15-34 years of age, collected in a cooperative multicenter study group (Pathobiological Determinants of Atherosclerosis in Youth) was examined in ..
  53. doi Intrahepatic role of exchangeable apolipoproteins in lipoprotein assembly and secretion
    Meenakshi Sundaram
    Department of Biochemistry, Microbiology, and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ontario, Canada
    Arterioscler Thromb Vasc Biol 32:1073-8. 2012
    Exchangeable apolipoproteins, composed mainly of amphipathic α-helices, are associated with various plasma lipoproteins and play an important role in the metabolism of those lipoproteins to which they bind...
  54. doi Characteristics of apolipoprotein M and its relation to atherosclerosis and diabetes
    Yan wei Hu
    Laboratory Medicine Center, Nangfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China
    Biochim Biophys Acta 1801:100-5. 2010
    ..Here, we review the progress made in understanding the structure, distribution, and regulation of apoM and its potential role in lipoprotein metabolism, diabetes, and atherosclerosis...
  55. ncbi Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins
    Hiroyuki Saito
    Lipid Research Group, The Children s Hospital of Philadelphia, Abramson Research Center, Suite 1102, 3615 Civic Center Boulevard, University of Pennsylvania School of Medicine, Philadelphia, 19104 4318, USA
    Prog Lipid Res 43:350-80. 2004
    Exchangeable apolipoproteins function in lipid transport as structural components of lipoprotein particles, cofactors for enzymes and ligands for cell-surface receptors...
  56. ncbi APOA5 polymorphisms influence plasma triglycerides in young, healthy African Americans and whites of the CARDIA Study
    Kathy L E Klos
    Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA
    J Lipid Res 46:564-71. 2005
    ..46% among white males, and 0-0.69% among African American females. The results of our study suggest a small but replicable context-dependent influence of the APOA5 gene region on plasma TG levels in young, healthy individuals...
  57. pmc Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
    Christina Christoffersen
    Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 108:9613-8. 2011
    ..Our results demonstrate that apoM, by delivering S1P to the S1P(1) receptor on endothelial cells, is a vasculoprotective constituent of HDL...
  58. ncbi Synthesis, intracellular processing, and signal peptide of human apolipoprotein E
    V I Zannis
    J Biol Chem 259:5495-9. 1984
    ..These findings demonstrate that apo-E is synthesized as preprotein and undergoes intracellular proteolysis and glycosylation and extracellular desialation to attain the major asialoapo-E isoprotein form observed in plasma...
  59. ncbi Relevance of apolipoproteins in the development of fatty liver and fatty liver-related peripartum diseases in dairy cows
    Norio Katoh
    Hokkaido Research Station, National Institute of Animal Health, Sapporo, Japan
    J Vet Med Sci 64:293-307. 2002
    ..Moreover, determination of the apolipoprotein concentrations and enzyme activity during the peripartum period is useful for early diagnoses of these diseases...
  60. ncbi Apolipoproteins C-III and A-V as predictors of very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics
    Dick C Chan
    Metabolic Research Center, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia
    Arterioscler Thromb Vasc Biol 26:590-6. 2006
    ..We also explored the relationship between these parameters of VLDL metabolism and VLDL-apoC-III kinetics...
  61. doi Liver X receptor agonist downregulates hepatic apoM expression in vivo and in vitro
    Xiaoying Zhang
    Comprehensive Laboratory, The Third Affiliated Hospital of Suzhou University, Changzhou 213003, China
    Biochem Biophys Res Commun 371:114-7. 2008
    ..The combination of RA and T0901317 showed additive effects, which suggests that apoM expression can be modulated by LXR/RXR pathway...
  62. doi Human innate immunity against African trypanosomes
    Etienne Pays
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Curr Opin Immunol 21:493-8. 2009
    ..Hpr or apoL1 deficiency respectively leads to the reduction or abolishment of human protection against T. brucei...
  63. pmc Beef in an Optimal Lean Diet study: effects on lipids, lipoproteins, and apolipoproteins
    Michael A Roussell
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, USA
    Am J Clin Nutr 95:9-16. 2012
    ..A Step I diet with lean beef compared with lean white meat both decrease LDL cholesterol. To our knowledge, no studies have evaluated a low-saturated fatty acid (SFA) (<7% calories) diet that contains lean beef...
  64. ncbi The neurobiology of apolipoproteins in psychiatric disorders
    J Gregor Sutcliffe
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Mol Neurobiol 26:369-88. 2002
    ..With the high-throughput molecular profiling techniques available, apolipoproteins have emerged as being important factors in psychiatric disorders...
  65. ncbi A genetic variant of apolipoprotein M increases susceptibility to coronary artery disease in a Chinese population
    Wei Wei Xu
    Atherosclerosis Research Center, Nanjing Medical University, Nanjing, China
    Clin Exp Pharmacol Physiol 35:546-51. 2008
    ..819, 95% confidence interval 1.142-2.898; P = 0.012). 4. In conclusion, the results of the present study suggest that the APOM T-855C polymorphism carries an increased risk for CAD in this Chinese population...
  66. pmc Association of APOL1 variants with mild kidney disease in the first-degree relatives of African American patients with non-diabetic end-stage renal disease
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 82:805-11. 2012
    ..After adjustment, two APOL1 risk variants weakly predict mild forms of kidney disease. Second hits appear necessary for the initiation of APOL1-associated nephropathy...
  67. pmc Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis
    Hae Jin Hu
    Integrated Research Center for Genome Polymorphism, The Catholic University of Korea School of Medicine Seoul 137 701, Korea
    Exp Mol Med 43:613-21. 2011
    ..These results indicate that APOM promoter polymorphisms are significantly associated with the susceptibility to RA...
  68. ncbi Lipid transport biochemistry and its role in energy production
    R O Ryan
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Annu Rev Entomol 45:233-60. 2000
    ..The nature and structure of hemolymph lipid transfer particle and the potential role of a recently discovered lipoprotein receptor of the low-density lipoprotein receptor family, in lipophorin metabolism and lipid transport is reviewed...
  69. doi Structural changes in apolipoproteins bound to nanoparticles
    Risto Cukalevski
    Biochemistry and Structural Biology, Lund University, Lund, Sweden
    Langmuir 27:14360-9. 2011
    ..Thus, surface charge is a critical parameter for predicting structural changes in adsorbed proteins, yet the effect is specific for each protein...
  70. doi Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice
    Niels Nijstad
    Department of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Biochim Biophys Acta 1811:294-9. 2011
    ..These results demonstrate that although overexpression of apoO results in a substantial enrichment of HDL particles with this novel apolipoprotein, apoO does not impact the plasma lipoprotein profile or HDL functionality...
  71. pmc Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans
    Michael S Lipkowitz
    Division of Nephrology and Hypertension, Department of Medicine, Georgetown University School of Medicine, Washington, DC, USA
    Kidney Int 83:114-20. 2013
    ..APOL1 risk variants were consistently associated with renal disease progression across medication classes and blood pressure targets. Thus, kidney disease in AASK participants was strongly associated with APOL1 renal risk variants...
  72. ncbi The effects of adrenocorticotrophic hormone and an equivalent dose of cortisol on the serum concentrations of lipids, lipoproteins, and apolipoproteins
    Anna Lena Berg
    Department of Nephrology, University Hospital, Lund 221 85, Sweden
    Metabolism 55:1083-7. 2006
    ..These, in combination with previous in vitro results, indicated an ACTH-specific effect...
  73. ncbi Apolipoprotein and apolipoprotein receptor genes, blood lipids and disease
    Josep Ribalta
    Unitat de Recerca de Lipids i Arteriosclerosi, Facultat de Medicina, Hospital Universitari de Sant Joan, Institut de Recerca en Ciències de la Salut, Universitat Rovira i Virgili, Reus, Spain
    Curr Opin Clin Nutr Metab Care 6:177-87. 2003
    b>Apolipoproteins and their receptors are the main controllers of lipid metabolism and, as such, have a major impact not only on the risk of cardiovascular disease but also on the development and degeneration of the central nervous system...
  74. ncbi Human high density lipoproteins are platforms for the assembly of multi-component innate immune complexes
    April M Shiflett
    Josephine Bay Paul Center, Global Infectious Disease Program, Marine Biological Laboratory, Woods Hole, Massachussetts 02543, USA
    J Biol Chem 280:32578-85. 2005
    ..specific activities at least 500-fold less than those of native HDLs, suggesting that association of these apolipoproteins within the HDL particle was necessary for optimal cytotoxicity...
  75. ncbi Lipid response to a low-fat diet with or without soy is modified by C-reactive protein status in moderately hypercholesterolemic adults
    Kirsten F Hilpert
    Department of Nutritional Sciences, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, USA
    J Nutr 135:1075-9. 2005
    ..5%) compared with the run-in diet. These results suggest that inflammation may not only attenuate lipid responses, but also aggravate dyslipidemia in hypercholesterolemic subjects consuming a cholesterol-lowering diet...
  76. ncbi Effect of biological therapy on levels of atheroprotective antibodies against phosphorylcholine and apolipoproteins in rheumatoid arthritis - a one year study
    Sofia Ajeganova
    Karolinska University Hospital Huddinge, Stockholm, Sweden
    Clin Exp Rheumatol 29:942-50. 2011
    ..B-cell targeting rituximab influences novel markers of atherosclerosis and inflammation, such as atheroprotective natural IgM antibodies against phosphorylcholine (anti-PC), oxidised low-density lipoprotein (oxLDL) and apolipoproteins.
  77. pmc Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death
    Guanghua Wan
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Biol Chem 283:21540-9. 2008
    ..To our knowledge, this is the first BH3-only protein with lipid binding activity that, when overproduced intracellularly, induces AuCD...
  78. ncbi Concentration of Lp(a) and other apolipoproteins in predialysis, hemodialysis, chronic ambulatory peritoneal dialysis and post-transplant patients
    E Kimak
    Department of Clinical Analytics, University of Medicine, Lublin, Poland
    Clin Chem Lab Med 38:421-5. 2000
    Serum levels of lipids, lipoprotein(a) Lp(a) and other apolipoproteins were determined in 47 predialysis patients, 40 hemodialysis (HD) patients, 39 chronic ambulatory peritoneal dialysis (CAPD) patients, 11 patients after kidney ..
  79. pmc Genetics of kidney failure and the evolving story of APOL1
    David J Friedman
    Nephrology Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Clin Invest 121:3367-74. 2011
    ..The identification of these genetic factors will be critical for expanding our understanding of renal development and function as well as for the design of novel therapeutics for kidney disease...
  80. pmc Mass spectrometric determination of apolipoprotein molecular stoichiometry in reconstituted high density lipoprotein particles
    John B Massey
    Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Lipid Res 50:1229-36. 2009
    ..The method has the capability to determine the molecular ratio and molecular composition of apolipoprotein molecules in complex reconstituted HDL particles...
  81. ncbi Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins
    Bo Zhang
    Department of Cardiology, Fukuoka University School of Medicine, 7 45 1 Nanakuma Jonan ku, Fukuoka 814 0180, Japan
    Atherosclerosis 178:199-205. 2005
    ..We examined the relationship of lipoprotein-associated S1P concentrations with cholesterol (C) and apolipoprotein (apo) contents of lipoprotein and lipoprotein subfractions characterized by capillary isotachophoresis (cITP)...
  82. pmc Regulation of human apolipoprotein m gene expression by orphan and ligand-dependent nuclear receptors
    Ioanna Mosialou
    Department of Biochemistry, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology Hellas, Heraklion 71003, Greece
    J Biol Chem 285:30719-30. 2010
    ....
  83. doi Changes in HDL-associated apolipoproteins relate to mortality in human sepsis and correlate to monocyte and platelet activation
    Stefan Barlage
    Institute for Clinical Chemistry and Laboratory Medicine, University of Regensburg, 93042, Regensburg, Germany
    Intensive Care Med 35:1877-85. 2009
    ..In this study, we analyzed whether plasma concentrations of lipoproteins and apolipoproteins in human sepsis are related to patient survival and the activation of blood monocytes and platelets.
  84. doi Relative contribution of lipids and apolipoproteins to incident coronary heart disease and ischemic stroke: the PRIME Study
    Florence Canoui-Poitrine
    INSERM, U970, Paris Cardiovascular Research Center, Universite Paris Descartes, UMR S970, Paris, France
    Cerebrovasc Dis 30:252-9. 2010
    ....
  85. doi The trypanolytic factor of human serum: many ways to enter the parasite, a single way to kill
    Benoit Vanhollebeke
    Laboratory of Molecular Parasitology, IBMM, Universite Libre de Bruxelles, 12, rue des Professeurs Jeener et Brachet, B 6041 Gosselies, Belgium
    Mol Microbiol 76:806-14. 2010
    ..While Hpr is involved as TLF ligand, the lytic activity is due to apoL1, a Bcl-2-like pore-forming protein. We discuss the in vivo relevance of this uptake pathway in the context of other potentially redundant delivery routes...
  86. ncbi Apolipoprotein E polymorphism in men and women from a Spanish population: allele frequencies and influence on plasma lipids and apolipoproteins
    D Gomez-Coronado
    Servicio de Bioquímica Investigación, Hospital Ramon y Cajal, Ctra de Colmenar, Km 9, 28034, Madrid, Spain
    Atherosclerosis 147:167-76. 1999
    ..These effects were essentially maintained after excluding postmenopausal women and oral contraceptive users from the analysis...
  87. ncbi Apolipoprotein M--a novel player in high-density lipoprotein metabolism and atherosclerosis
    Bjorn Dahlback
    Department of Laboratory Medicine, Clinical Chemistry, Lund University, Wallenberg Laboratory, University Hospital, Malmo, Sweden
    Curr Opin Lipidol 17:291-5. 2006
    ..The purpose is to review recent information on the unusual structural properties of apolipoprotein M and its possible role in formation of pre-beta high-density lipoprotein and reverse cholesterol metabolism...
  88. ncbi APOA5-1131T>C polymorphism is associated with triglyceride levels in Chinese men
    L Baum
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin Genet 63:377-9. 2003
    ..The C allele is more common in Chinese than in Caucasians (26-40% vs. 8% of alleles), suggesting that the impact of this polymorphism on triglyceride levels in the population and therefore on public health is greater among Chinese...
  89. ncbi Contribution of APOA5 gene variants to plasma triglyceride determination and to the response to both fat and glucose tolerance challenges
    Steve Martin
    Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, 5 University Street, WC1E 6JF, London, UK
    Biochim Biophys Acta 1637:217-25. 2003
    ..Our results strongly support the role of APOA5 in determining plasma TG levels in an age-independent manner and highlight the importance of the APOC3/A4/A5 gene cluster in both TG and metabolic homeostasis...
  90. ncbi Regulation of anti-atherogenic apolipoprotein M gene expression by the orphan nuclear receptor LRH-1
    Nicolas Venteclef
    Cardiovascular and Urogenital Center of Excellence for Drug Discovery, GlaxoSmithKline, 25 Avenue du Quebec, 91951 Les Ulis, France
    J Biol Chem 283:3694-701. 2008
    ..Taken together, our results demonstrate that LRH-1 is a novel regulator of APOM transcription and further extend the role of this orphan nuclear receptor in lipoprotein metabolism and cholesterol homeostasis...
  91. pmc Association of trypanolytic ApoL1 variants with kidney disease in African Americans
    Giulio Genovese
    Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Science 329:841-5. 2010
    ..We speculate that evolution of a critical survival factor in Africa may have contributed to the high rates of renal disease in African Americans...
  92. ncbi ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis
    Frank G Schaap
    AMC Liver Center, Meibergdreef 69 71, 1105 BK Amsterdam, The Netherlands
    J Biol Chem 279:27941-7. 2004
    ..From these data, we conclude that apoAV is a potent stimulator of LPL activity. Thus, apoAV lowers plasma TG by both reducing the hepatic VLDL-TG production rate and by enhancing the lipolytic conversion of TG-rich lipoproteins...
  93. pmc Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function
    W Sean Davidson
    Department of Pathobiology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45221, USA
    Arterioscler Thromb Vasc Biol 29:870-6. 2009
    ..We hypothesized that distinct clusters of protein components may distinguish between physicochemically-defined subpopulations of HDL particles, and that such clusters may exert specific biological function(s)...
  94. ncbi Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins
    Stephanie T Shi
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Virology 292:198-210. 2002
    ....
  95. ncbi Effect of retinoic acid on cell proliferation and differentiation as well as on lipid synthesis, lipoprotein secretion, and apolipoprotein biogenesis
    Emilie Grenier
    Department of Nutrition, Universite de Montreal, Montreal, Quebec, Canada
    Am J Physiol Gastrointest Liver Physiol 293:G1178-89. 2007
    ..Taken together, these data highlight RA-induced cell differentiation via specific signaling without a significant impact on apo A-I synthesis...
  96. pmc ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death
    Siqin Zhaorigetu
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, School of Medicine, Albuquerque, New Mexico 87131 0001, USA
    Autophagy 4:1079-82. 2008
    ..Finally, we discuss the link between ApoL1 and various human diseases...
  97. doi Lipid profile, plasma apolipoproteins, and risk of a first myocardial infarction among Asians: an analysis from the INTERHEART Study
    Ganesan Karthikeyan
    Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India
    J Am Coll Cardiol 53:244-53. 2009
    ..This study sought to determine the prevalence of lipid and lipoprotein abnormalities and their association with the risk of a first acute myocardial infarction (AMI) among Asians...
  98. ncbi Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators
    Ngoc Vu-Dac
    Departement d Atherosclerose, U 545 INSERM, Institut Pasteur de Lille and Faculté de Pharmacie de Lille, 1 rue Calmette BP 245, 59019 Lille Cedex, France
    J Biol Chem 278:17982-5. 2003
    ..These findings demonstrate that APOA5 is a highly responsive peroxisome proliferator-activated receptor alpha target gene and support its role as a major mediator for how fibrates reduce plasma triglycerides in humans...
  99. ncbi The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins
    Peter J O'Brien
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Clin Chem 51:351-9. 2005
    ..Despite these compelling molecular biology data, relatively little is known about ApoA5 protein in human serum...
  100. pmc Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model
    Maria Pilar Molina-Portela
    Department of Medical Parasitology, New York University Langone Medical Center School of Medicine, New York, NY 10010, USA
    J Exp Med 205:1721-8. 2008
    ..We conclude that all three human apolipoproteins act cooperatively to achieve maximal killing capacity and that truncated apolipoprotein L-I does not function ..
  101. pmc Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11
    Michael Olivier
    Human and Molecular Genetics Center, Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Genomics 83:912-23. 2004
    ..These results highlight the complex genetic relationship between APOA5 and APOC3 and support the notion that APOA5 represents an independent risk gene affecting plasma triglyceride concentrations in humans...

Research Grants80

  1. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    ..These studies may help to devise new more specific and less harmful modalities than the anticoagulation or general immunosuppression currently used to treat and prevent thrombosis in patients with aPL Abs. ..
  2. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..Understanding the pathogenesis of the reactive form of amyloidosis may reveal avenues for treatment of not only AA amyloidosis but also other forms of amyloidosis in the Veteran population. ..
  3. Transplacental Arsenic Induced Hepatic Dysfunction and Vascular Disease
    J Christopher States; Fiscal Year: 2010
    ..This project uses a mouse model of fetal arsenic exposure induced vascular disease to investigate effects of fetal arsenic exposure on liver development that likely cause vascular disease by young adulthood. ..
  4. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    ..Several promising tools that may ultimately lead to valuable insight into how lymphatic disorders could be treated will be explored in this proposal. ..
  5. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..If we are correct, then our drug therapies should improve blood vessel function and decrease airway resistance in SCD mice with experimental asthma. ..
  6. Regulation of Triglyceride Metabolism by the transcription factor CREB-H
    Ann Hwee Lee; Fiscal Year: 2013
    ..CREB-H deficiency was associated with decreased expression of the LPL coactivators, Apoc2, Apoa4, and Apoa5 apolipoproteins and concurrent augmentation of the LPL inhibitor, Apoc3...
  7. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    ..lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides, and novel lipid markers of apolipoproteins A-1 and B100 , as well as long-term use of statins in relation to risk of total invasive cancer and breast, ..
  8. Inducible Macrophage Specific Gene Expression in Diseases
    JEANINE M D apos ARMIENTO; Fiscal Year: 2010
    ..We will also examine the consequences of the absence of macrophage tissue inhibitor of metalloproteinases-3 in lung injury. ..
  9. Sphingosine 1-phosphate and cardioprotection
    JOEL SAMUEL KARLINER; Fiscal Year: 2012
    ....
  10. Lipoprotein Structure and Function by Individual Particle Electron Tomography
    Gang Ren; Fiscal Year: 2013
    ..Plasma HDL particles contain multiple apolipoproteins, but the most abundant is apoA-I...
  11. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  12. Pathogenesis of cognitive/neurologic deficits in central nervous system malaria
    Chandy C John; Fiscal Year: 2012
    ..The study therefore has the potential to lead to the prevention of brain injury in hundreds of thousands of children in sub-Saharan Africa. ..
  13. Novel mechanisms of niacin to improve HDL function: Role of myeloperoxidase
    Moti L Kashyap; Fiscal Year: 2013
    ..3. Define cellular mechanism of action of niacin on: MPO-mediated oxidative modification of HDL- apoAI, formation of "dysfunctional HDL", and improvement in HDL's anti-atherogenic properties. ..
  14. Selective Insulin Resistance- Diabetic Cardiovascular Diseases
    George L King; Fiscal Year: 2013
    ....
  15. Shared Mechanisms of Valvular and Vascular Calcification
    JOEL DAVID MORRISETT; Fiscal Year: 2012
    ....
  16. Longitudinal Study of Lipids and APOE in the Development of AD and AD Pathology
    Michelle M Mielke; Fiscal Year: 2013
    ....
  17. Molecular mechanism of apolipoprotein binding to lipopolysaccharides
    PAUL MICHIEL WEERS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Apolipoproteins are abundant serum proteins and well known for their role in lipid transport processes...
  18. Exploring Human-Induced Pluripotent Stem Cells for Alzheimer's Disease Research
    Kuo Fen Lee; Fiscal Year: 2012
    ..Ultimately, we aim to develop genetic or chemical treatments that disrupt molecular pathways that lead to AD. ..
  19. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..2) To determine if COG112 exerts neuroprotective and neurorestorative effects in vivo by functional and histological examination in a DPN model of BKS db/db mice. ..
  20. Subtype Specific LXR Activity Limits Atherosclerosis
    Ira G Schulman; Fiscal Year: 2013
    ..The results of these studies should provide innovative strategies for the development of therapies for the treatment of cardiovascular disease. ..
  21. BRAIN LIPID METABOLISM, DENDRITES AND SYNAPSES IN AGING AND ALZHEIMER'S DISEASE
    Guojun Bu; Fiscal Year: 2013
    ..Our studies may also define apoE and apoE receptors as critical targets for AD therapy. ..
  22. Investigation of Nephrotic Syndrome
    LIONEL CLAUDIUS CLEMENT; Fiscal Year: 2013
    ..the surface of HDL and inhibits endothelium bound lipoprotein lipase directly, and via its interaction with apolipoproteins C-II and C-III...
  23. Multifunctional nanoformulations for diagnostic imaging of atherosclerosis
    Alexander B Sigalov; Fiscal Year: 2012
    ....
  24. Clinical and Molecular Biology of Acute and Chronic Traumatic Encephalopathies
    JAMES WAVELL AIKEN; Fiscal Year: 2011
    ....
  25. Intestinal Triacylglycerol Metabolism and Energy Balance
    Chi Liang Eric Yen; Fiscal Year: 2013
    ..This work will both increase knowledge about a central component of metabolism as well as provide insights into potential therapies for addressing the obesity epidemic. ..
  26. The Metabolic Impact of Congenital Heterozygous ApoC-III Deficiency in Humans
    TONI ILANA POLLIN; Fiscal Year: 2013
    ..This project will look more closely at the effects of the deficiency on human metabolism to better understand the function of the apoC-III protein and its potential as a drug target. ..
  27. Nanoliposome-based Treatment of Amyloid Protein (AL) Toxicity
    RAYMOND QUEZON MIGRINO; Fiscal Year: 2013
    ....
  28. Aging of brain: effects of perinatal nutrition
    Jan Krzysztof Blusztajn; Fiscal Year: 2010
    ..The ultimate goal of our studies is to relate our results to the age-associated changes in memory in humans, and to develop perinatal nutritional strategies which could benefit people. ..
  29. Serum amyloid P and chronic noncommunicable diseases
    Weibin Shi; Fiscal Year: 2010
    ..lesions with a concentration approximately 50 times higher than plasma, where it colocalizes with apolipoproteins, including apoA-I, apoB, apoC-II, and apoE...
  30. Role of apolipoprotein M in acute kidney injury
    Didier Portilla; Fiscal Year: 2012
    ..The use of PPARalpha ligand like fibrates offers a novel therapeutic tool to reduce kidney tissue damage, and to reduce the high morbidity and mortality associated with the development of AKI ..
  31. APOLIPOPROTEIN GENES AND ATHEROGENESIS IN ANIMALS
    Nobuyo Maeda; Fiscal Year: 2012
    ..Using mouse genetics as a tool, we aim to determine how some common human genetic differences affect atherosclerosis and how the genetic effects are influenced by being overweight and by other common gene variants. ..
  32. Endoplasmic reticulum stress and foam cell formation
    Zhongmao Guo; Fiscal Year: 2010
    ..Finding from this work should contribute to understanding of the molecular mechanism of foam cell formation, and provide strategies for treatment or prevention of atherosclerosis by inhibition of endoplasmic reticulum stress. ..
  33. Mechanisms of Resistance and Susceptibility to African Trypanosome Infection
    Stephen L Hajduk; Fiscal Year: 2013
    ..This may allow us to develop novel approaches for the treatment of this important human disease. ..
  34. Role of LXR and ABCA1 in Abeta Aggregation and Toxicity
    NICHOLAS FRANCIS FITZ; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The Abca1 and apolipoproteins regulate cholesterol and phospholipids efflux, and HDL formation. Abca1 ko mice exhibit decreased cholesterol efflux and poorly-lipidated ApoA-l and ApoE...
  35. Lipoproteins and Microbial Immunity
    HOBART WHITAKER HARRIS; Fiscal Year: 2013
    ....
  36. Cholecystokinin - Role in postprandial gastric motility
    Helen E Raybould; Fiscal Year: 2013
    ....
  37. Ozone, apoE4, aging, and Alzheimer's disease
    Rui Ming Liu; Fiscal Year: 2013
    ..The results will have major impact in the field and may lead to the development of novel strategies for the prevention and treatment of AD. ..
  38. ENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESIS
    NICHOLAS DAVIDSON; Fiscal Year: 2013
    ....
  39. Selenium, other risk factors and cognitive decline in rural elderly Chinese
    Sujuan Gao; Fiscal Year: 2013
    ....
  40. Underlying Mechanisms of ApoE in HCV Infection and Assembly
    GUANGXIANG GEORGE LUO; Fiscal Year: 2013
    ..The studies described in this application will also provide novel targets for anti-HCV drug discovery. ..
  41. A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline
    Jae H Kang; Fiscal Year: 2013
    ..We propose an exciting substudy, incorporating cognitive testing among VITAL participants aged 65+ years to evaluate whether marine omega-3 fatty and vitamin D may be important in the maintenance of cognitive function in men and women. ..
  42. Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down's Syndrome and Dementia
    GARY WILLIAM SMALL; Fiscal Year: 2013
    ..Given the many people suffering from these neurodegenerative diseases, the potential impact of this study will be considerable, possibly improving the quality of life for millions of patients and their families. ..
  43. PET and MRI Neuronal Loss and Amyloid and Tau Deposition in Alzheimer Disease
    Laurel Martin-Harris; Fiscal Year: 2012
    ..At the same time this investigation will contribute to our knowledge of the effects of healthy aging on human learning and memory. ..
  44. Molecular Basis of Autosomal Dominant Hypercholesterolemia in a Multiethnic Cohor
    Zahid Ahmad; Fiscal Year: 2013
    ..The studies outlined in this project will provide the basis for the development of new therapeutic options for the prevention of this potentially life-threatening chronic disease. ..
  45. Stem Cell Models of Familial Combined Hypolipidemia
    Kiran Musunuru; Fiscal Year: 2013
    ..If successful, our approach of using genome-edited, hPSC-derived cells to study the effects of disease-associated mutations could be applied widely to a large variety of human genetic disorders. ..
  46. ApoE receptor pathways and abeta metabolism
    Guojun Bu; Fiscal Year: 2013
    ..Together, our proposed studies will likely provide insight into the mechanisms underlying A[unreadable] clearance and aggregation pathways in the brain and uncover how apoE isoforms and apoE receptors regulate these events in AD. ..
  47. Does Diabetic Hyperglycemia Regulate Atherosclerosis Progression and Regression?
    ROBERT RAFFAI; Fiscal Year: 2013
    ..Our long-term goals are to identify mechanisms that could serve as therapeutic targets to delay the progression and accelerate the regression of atherosclerosis as treatments for PAD in diabetic individuals. ..
  48. Bioluminescence Imaging of Atherosclerosis Associated Reactive Oxygen Species
    REECE JOSEPH GOIFFON; Fiscal Year: 2013
    ..This could allow earlier diagnosis and treatment and thus save more lives, all without any harmful radiation or highly invasive procedures. ..
  49. Screens for novel compounds to correct diabetic postprandial dyslipidemia
    Kevin Jon Williams; Fiscal Year: 2011
    ..The ultimate goal will be to avert the tremendous excess burden of cardiovascular disease in diabetes. ..
  50. PROTEINS OF COAGULATION PATHWAYS
    John H Griffin; Fiscal Year: 2013
    ..This project will reveal new insights into the pathophysiology of thrombosis and may improve diagnosis and treatment of thrombosis. ..
  51. Role of Genes in Exceptional Longevity in Humans
    NIR J BARZILAI; Fiscal Year: 2012
    ..These insights may lead to novel preventive and treatment strategies for these diseases that will have a profound impact on morbidity and mortality, and will enhance the quality of life in the elderly. ..
  52. PHOSPHOINOSITIDE SIGNALING TO AND WITHIN THE NUCLEUS
    Richard A Anderson; Fiscal Year: 2012
    ..The regulation of pre-mRNA polyadenylation by phosphoinositide signals via PIPKI[unreadable] and Star-PAP is an incredibly novel finding that has many implications for nuclear signal transduction and gene expression. ..
  53. RAGE, Macrophages &HDL Biology
    Ann Marie Schmidt; Fiscal Year: 2013
    ..Taken together, this work will uncover novel therapeutic strategies to enhance HDL function and cardiovascular health. ..
  54. Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia
    Jean Marc Schwarz; Fiscal Year: 2013
    ..A second objective is to determine the doses of HFCS that increase the absolute and proportional contributions of DNL-fatty acids to postprandial TRL. ..
  55. A novel peptide therapy for treatment of herpetic stromal keratitis
    Partha S Bhattacharjee; Fiscal Year: 2010
    ..We propose to investigate the effectiveness of two small peptides for their anti-viral and anti-inflammatory properties for the treatment of HSK. ..
  56. Investigational Safety and Toxicity Studies of Subcutaneous COG1410 for Alzheimer
    MICHAEL PETER VITEK; Fiscal Year: 2013
    ..With clinical studies showing that subcutaneous COG1410 can be safely given to human subjects, we will have achieved a significant milestone that reduces the risks and enables substantive commercialization activities to proceed. ..
  57. PTSD, Sleep-Disordered Breathing and APOE Genotype: Effects on Cognition
    Jerome A Yesavage; Fiscal Year: 2013
    ....
  58. Targeting the Foam Cell to Prevent Atherosclerosis
    ANTONIO PAUL; Fiscal Year: 2013
    ....
  59. Discovery of Novel Interventions of the Antiphospholipid Syndrome
    Chieko Mineo; Fiscal Year: 2013
    ..Together these aims will determine how aPL cause leukocyte adhesion and thrombosis and test potential therapeutic strategies to prevent aPL-mediated vascular dysfunction. ..
  60. METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2
    JOACHIM J HERZ; Fiscal Year: 2013
    ....
  61. Mechanisms of Fibronectin Extra Domain A in Atherosclerosis
    Anil Kumar Chauhan; Fiscal Year: 2013
    ....
  62. Prev. of Cardiovas. Complications of Pediatric SLE: Artherosclerosis Prev in Pedi
    Laura E Schanberg; Fiscal Year: 2009
    ..abstract_text> ..
  63. MOLECULAR MECHANISMS OF OXIDATION OF LDL
    Sampath Parthasarathy; Fiscal Year: 1999
    ..g., BSA), polyamino acids, amino acids, apolipoproteins and alkylamines. Some incubations will be conducted in the presence of antioxidants...
  64. Long Term Outcomes in ICU Patients: Delirium & Apolipoprotein E
    Sheila Alexander; Fiscal Year: 2009
    ..This would likely lead to decreased time in the ICU and hospital. ..
  65. APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Lawrence Chan; Fiscal Year: 2004
    ..Thus, the overall project is highly relevant to lipid nutrient absorption and homeostasis. Significantly, it also provides important information on a newly described pathway in posttranscriptional gene regulation. ..
  66. ASSEMBLY OF NASCENT PLASMA LIPOPROTEINS BY HEPATOCYTES
    Robert Hamilton; Fiscal Year: 1991
    ..goals of this research are to determine the mechanisms by which hepatocytes secrete lipoproteins and apolipoproteins. Hepatocytes secrete most of the plasma lipoproteins, and these same cells are the principal site of their ..
  67. EFFECT OF APOLIPOPROTEIN STRUCTURAL ADAPTABILITY
    ROBERT O apos MARA RYAN; Fiscal Year: 2010
    ..Results obtained will improve understanding of how apoE regulates lipid metabolism and its association with disease susceptibility. ..
  68. APOLIPOPROTEIN E BINDING TO RECEPTORS
    David Chappell; Fiscal Year: 1991
    ..on binding of the number of apo-E molecules per particle, the lipid composition, and the presence of other apolipoproteins will be investigated on native and synthetic lipoproteins in vitro...
  69. CEREBROVASCULAR AMYLOIDOSIS
    Peter Gorevic; Fiscal Year: 1999
    ..are intimately associated with other constituents, notably including P-component, proteoglycans, and certain apolipoproteins, several of which also circulate in blood and other body fluids, some of which may be important in explaining ..
  70. INTESTINAL LIPOPROTEINS IN THE NEONATE
    Dennis Black; Fiscal Year: 2007
    ..is due to increased size of secreted lipoproteins, and the particles have a normal complement of other apolipoproteins; b) absorbed fatty acid type (chain length or saturation) has an effect on the lipid secretory enhancement by ..
  71. Apolipoprotein A-V: A Functional Proteomics Study
    ROBERT O apos MARA RYAN; Fiscal Year: 2010
    ..Whereas factors such as lipoprotein lipase and apolipoproteins C-II / C-III are known to modulate plasma TG levels, accumulating evidence suggests the recently discovered ..
  72. APOLIPOPROTEIN E AND THE ISCHEMIC BRAIN
    David Warner; Fiscal Year: 2001
    ..We believe that this information would be of substantial value in defining both the relevance of Apo E mechanisms to ischemic outcome and provide a basis for therapeutic approaches to the treatment of stroke. ..
  73. EDITING OF APOLIPOPROTEIN-B MRNA
    DONNA DRISCOLL; Fiscal Year: 2004
    ..The successful pursuit of these aims should provide insight into the mechanism of apo-B mRNA editing and the function of ACF. ..
  74. DIETARY CHOLESTEROL EFFECTS ON PLASMA LIPOPROTEINS
    PHYLLIS MCPHERSON; Fiscal Year: 1990
    ....
  75. MECHANISM OF APOLIPOPROTEIN B-48 BIOGENESIS
    Lawrence Chan; Fiscal Year: 1993
    ..The proposed work will shed light on this process, which also has profound implications for general cell and molecular biology...
  76. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
    ..We believe that these studies will provide new knowledge on the function of apo A-IV in the complex process of lipoprotein assembly relevant to the dietary control of atherosclerotic cardiovascular disease and obesity. ..
  77. NEUROHORMONAL CONTROL OF INTESTINAL APOLIPOPROTEIN A IV
    Theodore Kalogeris; Fiscal Year: 2001
    ..This research is the first to examine the relationship between the brain-gut axis and intestinal apolipoprotein A-IV. It will greatly enhance our understanding of the control of this important protein. ..
  78. GENETIC EPIDEMIOLOGY OF ELEVATED APOB LEVEL
    GAIL JARVIK; Fiscal Year: 1999
    ..Aim 5. To refine the position of the apolipoprotein B elevating level gene(s). Aim 6. Subsequent work to identify the locus if positive evidence of linkage to a strong candidate gene region is obtained. ..
  79. Apolipoprotein E Genotype and Cognitive Performance in Breast Cancer Survivors
    Brent Small; Fiscal Year: 2007
    ..In the current proposal, we examine the potential of APOE-e4 genotype, known risk factor for Alzheimer's disease, to predispose breast cancer survivors for poor cognitive outcomes. [unreadable] [unreadable] [unreadable]..
  80. APOLIPOPROTEIN E IN CHOLESTEROL TRANSPORT AND METABOLISM
    ROBERT PITAS; Fiscal Year: 1992
    ..Together, these studies will help elucidate the role of apo-E in normal nervous tissue and in nerve regeneration...