serum albumin

Summary

Summary: A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.

Top Publications

  1. ncbi Structural basis of the drug-binding specificity of human serum albumin
    Jamie Ghuman
    Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    J Mol Biol 353:38-52. 2005
  2. ncbi Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles
    Felix Kratz
    Head of Macromolecular Prodrugs, Tumor Biology Center, Breisacher Strasse 117, D 79106 Freiburg, Germany
    J Control Release 132:171-83. 2008
  3. ncbi Crystal structure of human serum albumin at 2.5 A resolution
    S Sugio
    Osaka Laboratories, Yoshitomi Pharmaceutical Industries Ltd, 2 25 1, Shodai Ohtani, Hirakata, Osaka 573 1153, Japan
    Protein Eng 12:439-46. 1999
  4. pmc Large-scale production of functional human serum albumin from transgenic rice seeds
    Yang He
    Engineering Research Center for Plant Biotechnology and Germplasm Utilization, Ministry of Education, State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan 430072, China
    Proc Natl Acad Sci U S A 108:19078-83. 2011
  5. ncbi Human serum albumin: from bench to bedside
    Gabriella Fanali
    Department of Biomedical, Informatics and Communication Sciences, University of Insubria, Busto Arsizio VA, Italy
    Mol Aspects Med 33:209-90. 2012
  6. ncbi Atomic structure and chemistry of human serum albumin
    X M He
    Space Science Laboratory, Marshall Space Flight Center, Huntsville, Alabama 35812
    Nature 358:209-15. 1992
  7. ncbi The antioxidant properties of serum albumin
    Marjolaine Roche
    Laboratoire de Biochimie et Genetique Moleculaire, Universite de la Reunion, Saint Denis de La Réunion, France
    FEBS Lett 582:1783-7. 2008
  8. pmc Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature
    Digant Gupta
    Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL, USA
    Nutr J 9:69. 2010
  9. ncbi The glycation of albumin: structural and functional impacts
    Philippe Rondeau
    Laboratoire de Biochimie et Génétique Moléculaire LBGM Groupe d Etude sur l Inflammation Chronique et l Obésité GEICO, Universite de la Reunion, Saint Denis de La Réunion, France
    Biochimie 93:645-58. 2011
  10. ncbi C-Reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients
    J Y Yeun
    Department of Medicine, Division of Nephrology, and the Department of Statistics, University of California Davis, Sacramento 95817, USA
    Am J Kidney Dis 35:469-76. 2000

Detail Information

Publications306 found, 100 shown here

  1. ncbi Structural basis of the drug-binding specificity of human serum albumin
    Jamie Ghuman
    Biophysics Section, Division of Cell and Molecular Biology, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    J Mol Biol 353:38-52. 2005
    Human serum albumin (HSA) is an abundant plasma protein that binds a remarkably wide range of drugs, thereby restricting their free, active concentrations...
  2. ncbi Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles
    Felix Kratz
    Head of Macromolecular Prodrugs, Tumor Biology Center, Breisacher Strasse 117, D 79106 Freiburg, Germany
    J Control Release 132:171-83. 2008
    ....
  3. ncbi Crystal structure of human serum albumin at 2.5 A resolution
    S Sugio
    Osaka Laboratories, Yoshitomi Pharmaceutical Industries Ltd, 2 25 1, Shodai Ohtani, Hirakata, Osaka 573 1153, Japan
    Protein Eng 12:439-46. 1999
    A new triclinic crystal form of human serum albumin (HSA), derived either from pool plasma (pHSA) or from a Pichia pastoris expression system (rHSA), was obtained from polyethylene glycol 4000 solution...
  4. pmc Large-scale production of functional human serum albumin from transgenic rice seeds
    Yang He
    Engineering Research Center for Plant Biotechnology and Germplasm Utilization, Ministry of Education, State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan 430072, China
    Proc Natl Acad Sci U S A 108:19078-83. 2011
    Human serum albumin (HSA) is widely used in clinical and cell culture applications. Conventional production of HSA from human blood is limited by the availability of blood donation and the high risk of viral transmission from donors...
  5. ncbi Human serum albumin: from bench to bedside
    Gabriella Fanali
    Department of Biomedical, Informatics and Communication Sciences, University of Insubria, Busto Arsizio VA, Italy
    Mol Aspects Med 33:209-90. 2012
    Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multi-domain macromolecule, representing the main determinant of plasma oncotic pressure and the main modulator of fluid distribution between body ..
  6. ncbi Atomic structure and chemistry of human serum albumin
    X M He
    Space Science Laboratory, Marshall Space Flight Center, Huntsville, Alabama 35812
    Nature 358:209-15. 1992
    The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule...
  7. ncbi The antioxidant properties of serum albumin
    Marjolaine Roche
    Laboratoire de Biochimie et Genetique Moleculaire, Universite de la Reunion, Saint Denis de La Réunion, France
    FEBS Lett 582:1783-7. 2008
    ..In particular, we describe the role of albumin in ligand binding and free radical-trapping activities. In addition, physiological and pathological situations that modify the antioxidant properties of albumin are reported...
  8. pmc Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature
    Digant Gupta
    Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion, IL, USA
    Nutr J 9:69. 2010
    There are several methods of assessing nutritional status in cancer of which serum albumin is one of the most commonly used...
  9. ncbi The glycation of albumin: structural and functional impacts
    Philippe Rondeau
    Laboratoire de Biochimie et Génétique Moléculaire LBGM Groupe d Etude sur l Inflammation Chronique et l Obésité GEICO, Universite de la Reunion, Saint Denis de La Réunion, France
    Biochimie 93:645-58. 2011
    ..The biological impact of glycated albumin on cell physiology is also discussed, specifically the role of the protein as a biological marker of diabetes...
  10. ncbi C-Reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients
    J Y Yeun
    Department of Medicine, Division of Nephrology, and the Department of Statistics, University of California Davis, Sacramento 95817, USA
    Am J Kidney Dis 35:469-76. 2000
    ..Patients were divided into four groups based on serum albumin levels (<3.5 [lowest quartile], 3.5 to 3.8, 3.9 to 4.0, and >4.0 g/dL [highest quartile])...
  11. ncbi An inflammation-based prognostic score and its role in the nutrition-based management of patients with cancer
    Donald C McMillan
    University Dept of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Proc Nutr Soc 67:257-62. 2008
    ..The role of GPS in clinical decision making will be discussed...
  12. ncbi Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites
    S Curry
    Blackett Laboratory, Imperial College, London, UK
    Nat Struct Biol 5:827-35. 1998
    Human serum albumin (HSA) is the most abundant protein in the circulatory system. Its principal function is to transport fatty acids, but it is also capable of binding a great variety of metabolites and drugs...
  13. ncbi The extraordinary ligand binding properties of human serum albumin
    Mauro Fasano
    Department of Structural and Functional Biology, University of Insubria, Center of Neurosciences, 21052 Busto Arsizio, Italy
    IUBMB Life 57:787-96. 2005
    Human serum albumin (HSA), the most prominent protein in plasma, binds different classes of ligands at multiple sites...
  14. ncbi C-reactive protein and albumin as predictors of all-cause and cardiovascular mortality in chronic kidney disease
    Vandana Menon
    Department of Medicine, Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 68:766-72. 2005
    ..There are limited data evaluating the relationships between CRP, albumin, and outcomes in chronic kidney disease (CKD) stages 3 and 4...
  15. pmc Pollutant-induced modulation in conformation and β-lactamase activity of human serum albumin
    Ejaz Ahmad
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India
    PLoS ONE 7:e38372. 2012
    Structural changes in human serum albumin (HSA) induced by the pollutants 1-naphthol, 2-naphthol and 8-quinolinol were analyzed by circular dichroism, fluorescence spectroscopy and dynamic light scattering...
  16. ncbi Comparison of glycated albumin and hemoglobin A1c concentrations in diabetic subjects on peritoneal and hemodialysis
    Barry I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Perit Dial Int 30:72-9. 2010
    ..Relative to hemoglobin A(1c) (HbA(1c)), percentage of glycated albumin (GA%) more accurately reflects recent glycemic control in diabetic hemodialysis (HD) patients...
  17. ncbi Practical aspects of the ligand-binding and enzymatic properties of human serum albumin
    Ulrich Kragh-Hansen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Biol Pharm Bull 25:695-704. 2002
    ..mutants and X-ray crystallography has given much new information about the ligand-binding properties of human serum albumin (HSA)...
  18. ncbi Serum albumin level predicts initial intravenous immunoglobulin treatment failure in Kawasaki disease
    Ho Chang Kuo
    Department of Pediatrics, Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan
    Acta Paediatr 99:1578-83. 2010
    ..However, many patients with KD still show poor response to initial IVIG treatment. This study was conducted to investigate the risk factors for initial IVIG treatment failure in KD...
  19. ncbi Optimization of the preparation process for human serum albumin (HSA) nanoparticles
    K Langer
    Institut fur Pharmazeutische Technologie, Biozentrum Niederursel, Johann Wolfgang Goethe Universitat, Marie Curie Strasse 9, Frankfurt am Main D 60439, Germany
    Int J Pharm 257:169-80. 2003
    Nanoparticles prepared by desolvation and subsequent crosslinking of human serum albumin (HSA) represent promising carriers for drug delivery...
  20. ncbi Association of Malnutrition-Inflammation Score with quality of life and mortality in hemodialysis patients: a 5-year prospective cohort study
    Mehdi Rambod
    Harold Simmons Center for Kidney Disease Research and Epidemiology, CA, USA
    Am J Kidney Dis 53:298-309. 2009
    ..PEW) and inflammation, includes 7 components of the Subjective Global Assessment, body mass index, and serum albumin and transferrin concentrations...
  21. ncbi Serum albumin, C-reactive protein, interleukin 6, and fetuin a as predictors of malnutrition, cardiovascular disease, and mortality in patients with ESRD
    Hirokazu Honda
    Division of Renal Medicine, Department of Clinical Science, Interventions and Technology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Am J Kidney Dis 47:139-48. 2006
    b>Serum albumin (S-Alb), C-reactive protein (CRP), and interleukin 6 (IL-6) predict malnutrition, atherosclerotic cardiovascular disease (CVD), and mortality in patients with end-stage renal disease (ESRD)...
  22. ncbi Stabilization and encapsulation of recombinant human erythropoietin into PLGA microspheres using human serum albumin as a stabilizer
    Jintian He
    Hebei Normal University, Hebei Province, People s Republic of China he
    Int J Pharm 416:69-76. 2011
    ..recombinant human erythropoietin (rhEPO) loaded poly(lactic-co-glycolic acid) (PLGA) microspheres using human serum albumin (HSA) as a stabilizer...
  23. pmc Human serum albumin can regulate amyloid-β peptide fiber growth in the brain interstitium: implications for Alzheimer disease
    Helen F Stanyon
    School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, United Kingdom
    J Biol Chem 287:28163-8. 2012
    ..Human serum albumin (HSA) binds 95% of Aβ in blood plasma and is thought to inhibit plaque formation in peripheral tissue...
  24. ncbi Levels of lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus
    Sivaraman Arumugam Balasubramanian
    Brien Holden Vision Institute, Sydney, NSW 2052, Australia
    Exp Eye Res 96:132-7. 2012
    ..This study was designed to examine the levels of total protein, lactoferrin, secretory IgA and serum albumin in the tear film of people with keratoconus...
  25. pmc Serum albumin and mortality risk in a hyperendemic area of HCV infection in Japan
    Yumiko Nagao
    Department of Digestive Disease Information and Research, Kurume University School of Medicine, Kurume, Fukuoka, 830 0011, Japan
    Virol J 7:375. 2010
    ..This follow-up study determined, through a period of 12 years, whether serum albumin levels impact on the life prognosis of the residents of X town.
  26. pmc Stereo-selectivity of human serum albumin to enantiomeric and isoelectronic pollutants dissected by spectroscopy, calorimetry and bioinformatics
    Ejaz Ahmad
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India
    PLoS ONE 6:e26186. 2011
    ..These pollutants when ingested are transported in the blood by proteins like human serum albumin (HSA)...
  27. ncbi Glomerular sieving coefficient of serum albumin in the rat: a two-photon microscopy study
    George A Tanner
    Department of Cellular and Integrative Physiology, Indiana Univ School of Medicine, 635 Barnhill Drive, MS 332, Indianapolis, IN 46202, USA
    Am J Physiol Renal Physiol 296:F1258-65. 2009
    Recent studies of the sieving of serum albumin in the rat kidney using a two-photon microscope suggested that the glomerular sieving coefficient (GSC) of albumin is 0.034, much higher than earlier micropuncture determinations...
  28. pmc Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
    Safaa Sebak
    Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
    Int J Nanomedicine 5:525-32. 2010
    ..Nanoparticles made of human serum albumin (HSA) represent promising strategy for targeted drug delivery to tumor cells by enhancing the drug's ..
  29. ncbi Enhanced drug targeting by attachment of an anti alphav integrin antibody to doxorubicin loaded human serum albumin nanoparticles
    Sylvia Wagner
    Fraunhofer Institute for Biomedical Engineering, D 66386 St Ingbert, Germany
    Biomaterials 31:2388-98. 2010
    ..Here, DI17E6 was covalently coupled to human serum albumin nanoparticles. Resulting nanoparticles specifically targeted alphavbeta3 integrin positive melanoma cells...
  30. ncbi Albumin: biochemical properties and therapeutic potential
    Gregory J Quinlan
    Department of Critical Care Medicine, Imperial College School of Medicine, Royal Brompton Hospital, London, UK
    Hepatology 41:1211-9. 2005
  31. ncbi Lessons from the crystallographic analysis of small molecule binding to human serum albumin
    Stephen Curry
    Biophysics Section, Blackett Laboratory, Imperial College, United Kingdom
    Drug Metab Pharmacokinet 24:342-57. 2009
    Human serum albumin (HSA) is an abundant and highly soluble plasma protein with the capacity to bind a remarkably diverse set of lipophilic anionic compounds so that it fulfils important roles in the transport of nutrients, hormones and ..
  32. ncbi Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer
    Donald C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Int J Colorectal Dis 22:881-6. 2007
    ..The aim of the study was to examine the value of the combination of an elevated C-reactive protein and hypoalbuminaemia (GPS) in predicting cancer-specific survival after resection for colon and rectal cancer...
  33. pmc Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials
    Jean Louis Vincent
    Department of Intensive Care, Universite Libre de Bruxelles, Hopital Erasme, Brussels, Belgium
    Ann Surg 237:319-34. 2003
    ..To determine whether hypoalbuminemia is an independent risk factor for poor outcome in the acutely ill, and to assess the potential of exogenous albumin administration for improving outcomes in hypoalbuminemic patients...
  34. ncbi Reversible and covalent binding of drugs to human serum albumin: methodological approaches and physiological relevance
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, Bologna, 40126, Italy
    Curr Med Chem 9:1463-81. 2002
    Human serum albumin (HSA) plays a fundamental role in the transport of drugs, metabolites, and endogenous ligands...
  35. ncbi Pharmaceutical strategies utilizing recombinant human serum albumin
    Victor Tuan Giam Chuang
    Faculty of Pharmaceutical Sciences, Kumamoto University, Japan
    Pharm Res 19:569-77. 2002
    Gene manipulation techniques open up the possibility of making recombinant human serum albumin (rHSA) or mutants with desirable therapeutic properties and for protein fusion products...
  36. pmc Crystal structural analysis of human serum albumin complexed with hemin and fatty acid
    Patricia A Zunszain
    Department of Biological Sciences, Imperial College London, Room 746 Huxley Building, South Kensington Campus, London SW7 2AZ, United Kingdom
    BMC Struct Biol 3:6. 2003
    Human serum albumin (HSA) is an abundant plasma protein that binds a wide variety of hydrophobic ligands including fatty acids, bilirubin, thyroxine and hemin...
  37. ncbi Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids
    I Petitpas
    Biophysics Section, Department of Biological Sciences, Blackett Laboratory, Imperial College of Science, Technology and Medicine, London SW7 2BW, UK
    J Mol Biol 314:955-60. 2001
    The primary ligands of human serum albumin (HSA), an abundant plasma protein, are non-esterified fatty acids. In vivo, the majority of fatty acids associated with the protein are unsaturated...
  38. ncbi A malnutrition-inflammation score is correlated with morbidity and mortality in maintenance hemodialysis patients
    K Kalantar-Zadeh
    Division of Nephrology and Hypertension, Harbor UCLA Medical Center and the University of California Los Angeles, Torrance, CA 90509 2910, USA
    Am J Kidney Dis 38:1251-63. 2001
    ..To improve the DMS, we added three new elements to the 7 DMS components: body mass index, serum albumin level, and total iron-binding capacity to represent serum transferrin level...
  39. ncbi Ischemia modified albumin changes - review and clinical implications
    Eftihia Sbarouni
    2nd Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece
    Clin Chem Lab Med 49:177-84. 2011
    ..Preliminary data regarding the significance of IMA in the prognosis of either ACS or following revascularization need further study...
  40. pmc Serum albumin as a predictor of mortality in peritoneal dialysis: comparisons with hemodialysis
    Rajnish Mehrotra
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA, USA
    Am J Kidney Dis 58:418-28. 2011
    b>Serum albumin level predicts mortality in dialysis patients and is used to assess their health status and the quality of delivered care...
  41. ncbi Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures
    A A Bhattacharya
    Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine, London SW7 2BW, United Kingdom
    J Biol Chem 275:38731-8. 2000
    Human serum albumin (HSA) is one of the most abundant proteins in the circulatory system and plays a key role in the transport of fatty acids, metabolites, and drugs...
  42. ncbi Clinical impact of glycated albumin as another glycemic control marker
    Masafumi Koga
    Department of Internal Medicine, Kinki Central Hospital, Itami, Japan
    Endocr J 57:751-62. 2010
    ....
  43. ncbi Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats
    Jun Ichi Yokoe
    Pharmaceutical Research Division, Nipro Corporation, Shiga, Japan
    Int J Pharm 353:28-34. 2008
    To evaluate the effect of coupling of recombinant human serum albumin (rHSA) onto the surface of poly(ethylene glycol)-modified liposome (PEG liposome) on the in vivo disposition characteristics of liposomal doxorubicin (DXR), the ..
  44. ncbi Reassessment of albumin as a nutritional marker in kidney disease
    Allon N Friedman
    1481 W 10th Street 111N, Indianapolis, IN 46202, USA
    J Am Soc Nephrol 21:223-30. 2010
    ..federal agencies, health care payers, large dialysis organizations, and the research community to embrace serum albumin as an important index of nutrition and clinical performance is based on numerous misconceptions...
  45. ncbi Comparison of glycated albumin and hemoglobin A(1c) levels in diabetic subjects on hemodialysis
    T P Peacock
    Section of Nephrology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1053, USA
    Kidney Int 73:1062-8. 2008
    ..and negatively associated with the erythropoietin dose in hemodialysis patients, whereas these factors and serum albumin did not significantly impact glycated albumin levels...
  46. ncbi Afamin and apolipoprotein A-IV: novel protein markers for ovarian cancer
    Hans Dieplinger
    Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Cancer Epidemiol Biomarkers Prev 18:1127-33. 2009
    ..Afamin contributes, however, independent diagnostic information to CA125, thus establishing its potential as an adjunct marker to CA125...
  47. ncbi Probing the interaction of human serum albumin with ciprofloxacin in the presence of silver nanoparticles of three sizes: multispectroscopic and ζ potential investigation
    Hediyeh Iranfar
    Department of Biology, Faculty of Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran
    J Phys Chem B 116:1951-64. 2012
    The binding of ciprofloxacin to human serum albumin (HSA) in the presence and absence of silver nanoparticles of three sizes was investigated for the first time...
  48. ncbi Determinants of serum albumin concentration analyzed in a large cohort of patients on maintenance hemodialysis
    Stephan Thijssen
    Renal Research Institute, New York, New York 10128, USA
    J Ren Nutr 17:70-4. 2007
    b>Serum albumin concentration is a powerful predictor of mortality in patients on chronic hemodialysis (CHD). This study sought to investigate variables associated with serum albumin concentration.
  49. ncbi Allosteric and binding properties of Asp1-Glu382 truncated recombinant human serum albumin--an optical and NMR spectroscopic investigation
    Gabriella Fanali
    Dipartimento di Biologia Strutturale e Funzionale, Universita dell Insubria, Busto Arsizio, Italy
    FEBS J 276:2241-50. 2009
    Human serum albumin (HSA) is known for its exceptional ligand-binding capacity; indeed, its modular domain organization provides a variety of ligand-binding sites...
  50. ncbi Liver growth factor promotes the survival of grafted neural stem cells in a rat model of Parkinson's disease
    Diana Reimers
    Servicio de Neurobiologia, Hospital Ramon y Cajal, Madrid, Spain
    Curr Stem Cell Res Ther 7:15-25. 2012
    ....
  51. ncbi Fast gradient HPLC method to determine compounds binding to human serum albumin. Relationships with octanol/water and immobilized artificial membrane lipophilicity
    Klara Valko
    Computational, Analytical and Structural Sciences, GlaxoSmithKline, Gunnels Wood Road Stevenage, Herts SG1 2NY United Kingdom
    J Pharm Sci 92:2236-48. 2003
    A fast gradient HPLC method (cycle time 15 min) has been developed to determine Human Serum Albumin (HSA) binding of discovery compounds using chemically bonded protein stationary phases...
  52. ncbi Glycated albumin is a better glycemic indicator than glycated hemoglobin values in hemodialysis patients with diabetes: effect of anemia and erythropoietin injection
    Masaaki Inaba
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    J Am Soc Nephrol 18:896-903. 2007
    ..A significant negative correlation was found between GA and serum albumin (r = -0.131, P = 0...
  53. pmc The evaluation of the oxidative stress parameters in patients with primary angle-closure glaucoma
    Dong Chang
    First Affiliated Hospital, Harbin Medical University, Harbin, China
    PLoS ONE 6:e27218. 2011
    ..To clarify the presence of oxidative stress in patients with primary angle-closure glaucoma (PACG) and to investigate the relationship between oxidative stress and PACG...
  54. ncbi A human serum albumin-thioredoxin fusion protein prevents experimental contrast-induced nephropathy
    Azusa Kodama
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Chuo Ku, Kumamoto, Japan
    Kidney Int 83:446-54. 2013
    ..Thus, our results suggest that due to its long-acting properties, HSA-Trx has the potential to effectively prevent CIN...
  55. ncbi Targeted non-covalent self-assembled nanoparticles based on human serum albumin
    Anton Bunschoten
    Division of Diagnostic Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands
    Biomaterials 33:867-75. 2012
    Human serum albumin (HSA) is a biological nanocarrier that forms non-covalent complexes with a number of synthetic and biomolecules...
  56. ncbi Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in cynomolgus monkeys
    Blaire L Osborn
    Human Genome Sciences, Inc, 9410 Key West Avenue, Rockville, MD 20850, USA
    J Pharmacol Exp Ther 303:540-8. 2002
    ..To improve the pharmacokinetics of IFN-alpha and decrease dosing frequency, IFN-alpha was fused to human serum albumin producing a new protein, Albuferon...
  57. ncbi Ibuprofen induces an allosteric conformational transition in the heme complex of human serum albumin with significant effects on heme ligation
    Francesco P Nicoletti
    Dipartimento di Chimica, Universita di Firenze, Via della Lastruccia 3, I 50019 Sesto Fiorentino FI, Italy
    J Am Chem Soc 130:11677-88. 2008
    Human serum albumin (HSA), the most prominent protein in blood plasma, is able to bind a wide range of endogenous and exogenous compounds...
  58. ncbi Acute phase proteins and peritoneal dialysate albumin loss are the main determinants of serum albumin in peritoneal dialysis patients
    J Y Yeun
    Department of Medicine, University of California Davis, Sacramento 95817, USA
    Am J Kidney Dis 30:923-7. 1997
    ..hypoalbuminemia in a group of 27 patients on peritoneal dialysis (PD), we determined the relationship between serum albumin concentration and a group of parameters including dialysis dose delivered (Kt/V), normalized protein catabolic ..
  59. ncbi Increased glycated albumin and decreased esRAGE levels are related to angiographic severity and extent of coronary artery disease in patients with type 2 diabetes
    Lin Lu
    Department of Cardiology, Rui Jin Hospital, 197 Rui Jin Road II, Shanghai 200025, PR China
    Atherosclerosis 206:540-5. 2009
    ....
  60. ncbi Structural and immunological characterization of Amadori-rich human serum albumin: role in diabetes mellitus
    Binish Arif
    Department of Biochemistry, Faculty of Medicine, A M U, Aligarh 202002, UP, India
    Arch Biochem Biophys 522:17-25. 2012
    ..Quantization of EGPs of HSA by authentic antibodies against HSA-EGPs can be used as marker for early detection of the initiation/progression of secondary complications of diabetes...
  61. ncbi Serum albumin: relationship to inflammation and nutrition
    Burl R Don
    Division of Nephrology, Department of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Semin Dial 17:432-7. 2004
    ..Thus the inference from these clinical studies suggests that the cause of hypoalbuminemia, rather than low albumin levels specifically, is responsible for morbidity and mortality...
  62. pmc Structural basis of binding of fluorescent, site-specific dansylated amino acids to human serum albumin
    Ali J Ryan
    Biophysics Section, Blackett Laboratory, Imperial College, Exhibition Road, London SW7 2AZ, United Kingdom
    J Struct Biol 174:84-91. 2011
    Human serum albumin (HSA) has two primary binding sites for drug molecules...
  63. pmc Probing the binding sites of antibiotic drugs doxorubicin and N-(trifluoroacetyl) doxorubicin with human and bovine serum albumins
    Daniel Agudelo
    Departement de Chimie Biologie, Universite du Quebec a Trois Rivieres, Trois Rivieres, Quebec, Canada
    PLoS ONE 7:e43814. 2012
    We located the binding sites of doxorubicin (DOX) and N-(trifluoroacetyl) doxorubicin (FDOX) with bovine serum albumin (BSA) and human serum albumins (HSA) at physiological conditions, using constant protein concentration and various ..
  64. ncbi Interaction of (-)-epigallocatechin-3-gallate with human serum albumin: fluorescence, fourier transform infrared, circular dichroism, and docking studies
    Tushar Kanti Maiti
    Department of Chemistry, Indian Institute of Technology, Kharagpur, India
    Proteins 64:355-62. 2006
    ..The binding of EGCG with human serum albumin (HSA) has been investigated for the first time by using fluorescence, circular dichroism (CD), Fourier ..
  65. ncbi Allostery in a monomeric protein: the case of human serum albumin
    Paolo Ascenzi
    Department of Biology, University Roma Tre, Rome, Italy
    Biophys Chem 148:16-22. 2010
    Human serum albumin (HSA), the most prominent protein in plasma, binds different classes of ligands at multiple sites...
  66. ncbi Cross-talk between inflammation,coagulation/fibrinolysis and vascular access in hemodialysis patients
    E Costa
    Instituto de Ciências da Saúde da Universidade Católica Portuguesa, Porto, Portugal
    J Vasc Access 9:248-53. 2008
    ..and as inflammatory markers; C-reactive protein (CRP), soluble interleukin (IL)-2 receptor (s-IL2R), IL-6 and serum albumin levels...
  67. ncbi Properties and human origin of two angiotensin-I-converting enzyme inhibitory peptides isolated from a tryptic hydrolysate of human serum albumin
    K Nakagomi
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan
    Biol Pharm Bull 23:879-83. 2000
    Two angiotensin-I-converting enzyme (ACE) inhibitory peptides were isolated from a tryptic hydrolysate of human serum albumin (HSA)...
  68. ncbi Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activity
    Naila Ahmed
    Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
    J Biol Chem 280:5724-32. 2005
    Methylglyoxal is a potent glycating agent under physiological conditions. Human serum albumin is modified by methylglyoxal in vivo...
  69. ncbi Delta12-prostaglandin J2 as a product and ligand of human serum albumin: formation of an unusual covalent adduct at His146
    Satoru Yamaguchi
    Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Am Chem Soc 132:824-32. 2010
    Human serum albumin (HSA), the most abundant protein in plasma, has a very unique function, catalyzing the conversion of prostaglandin J(2) (PGJ(2)), a dehydration product of PGD(2), to yield Delta(12)-PGJ(2)...
  70. pmc Interaction of virstatin with human serum albumin: spectroscopic analysis and molecular modeling
    Tanaya Chatterjee
    Department of Biochemistry, Bose Institute, Kolkata, India
    PLoS ONE 7:e37468. 2012
    ..Here we report the interaction of virstatin with human serum albumin (HSA) using various biophysical methods...
  71. ncbi Stereoselective kinetics of warfarin binding to human serum albumin: effect of an allosteric interaction
    Ilona Fitos
    Department of Molecular Pharmacology, Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Chirality 14:442-8. 2002
    Kinetic and equilibrium binding studies were performed on the interaction of warfarin enantiomers with human serum albumin (HSA) in the absence and presence of lorazepam acetate (LoAc) enantiomers...
  72. ncbi The acute-phase response varies with time and predicts serum albumin levels in hemodialysis patients. The HEMO Study Group
    G A Kaysen
    Division of Nephrology, Department of Medicine, University of California Davis, 95616, USA
    Kidney Int 58:346-52. 2000
    Cross sectional studies have established that the serum albumin level is dependent on serum levels of acute-phase proteins (APPs) or cytokine levels in hemodialysis patients...
  73. pmc Structural and immunologic characterization of bovine, horse, and rabbit serum albumins
    Karolina A Majorek
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Mol Immunol 52:174-82. 2012
    b>Serum albumin (SA) is the most abundant plasma protein in mammals...
  74. ncbi Inflammation and dietary protein intake exert competing effects on serum albumin and creatinine in hemodialysis patients
    G A Kaysen
    Division of Nephrology, University of California, Davis, USA
    Kidney Int 60:333-40. 2001
    Cross-sectional studies have shown an inverse correlation between serum C-reactive protein (CRP) and serum albumin concentration in hemodialysis patients...
  75. ncbi Low preoperative serum albumin in colon cancer: a risk factor for poor outcome
    Cheng Chou Lai
    Division of Colon and Rectal Surgery, Department of Surgery, Chang Gung, Memorial Hospital, Linko, Taiwan
    Int J Colorectal Dis 26:473-81. 2011
    ..Malnutrition and comorbidities are frequently associated with these patients. The relationships between the preoperative malnutrition and the outcomes of colon cancer patients are unclear; this study aimed to clarify these issues...
  76. ncbi Effects of human serum albumin, ibuprofen and N-acetyl-L-cysteine against biofilm formation by pathogenic Escherichia coli strains
    P Naves
    Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundacion Jimenez Diaz Capio, Madrid, Spain
    J Hosp Infect 76:165-70. 2010
    The aim of this study was to evaluate the effects of human serum albumin (HSA), ibuprofen sodium (IBU) and N-acetyl-L-cysteine (NAC) against biofilm formation by seven biofilm-producing strains of Escherichia coli...
  77. ncbi Pharmacokinetics and biodistribution of human serum albumin-TIMP-2 fusion protein using near-infrared optical imaging
    Mi Sook Lee
    Division of Bio Imaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon 200 701, Republic of Korea
    J Pharm Pharm Sci 14:368-77. 2011
    ..The purpose of this work was to assess the PK and biodistribution of HSA/TIMP-2 as well as to quantify accumulated HSA/TIMP-2 in tumors...
  78. ncbi Copper transfer from Cu-Abeta to human serum albumin inhibits aggregation, radical production and reduces Abeta toxicity
    Lorena Perrone
    CNRS UMR 5089, Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne, Toulouse, France
    Chembiochem 11:110-8. 2010
    Amyloid-beta peptides (Abeta) and the protein human serum albumin (HSA) interact in vivo. They are both localised in the blood plasma and in the cerebrospinal fluid...
  79. ncbi Impairment of serum albumin antioxidant properties in obstructive sleep apnoea syndrome
    P Faure
    Dept of Integrated Biology, University Hospital Grenoble, Grenoble Cedex 09, France
    Eur Respir J 31:1046-53. 2008
    Antioxidant counteraction of oxidative stress has been poorly explored in obstructive sleep apnoea (OSA). Serum albumin is a major antioxidant agent and structural modifications induced by glucose or free radicals impair its antioxidant ..
  80. ncbi Initial glucose load predicts technique survival in patients on chronic peritoneal dialysis
    Hon Yen Wu
    Department of Internal Medicine, Yun Lin branch, National Taiwan University Hospital, Yun Lin, Taiwan
    Am J Nephrol 28:765-71. 2008
    ..We conducted this retrospective cohort analysis to investigate the impact of initial glucose load on long-term outcomes of PD patients...
  81. ncbi Improved expression and purification of recombinant human serum albumin from transgenic tobacco suspension culture
    Qiao Yang Sun
    State Key Laboratory of Biocontrol, Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat Sen University, Guangzhou, China
    J Biotechnol 155:164-72. 2011
    Most human serum albumin (HSA) for medical applications is derived from human plasma due to the lack of suitable heterologous expression systems for recombinant HSA (rHSA)...
  82. pmc Outcome predictability of biomarkers of protein-energy wasting and inflammation in moderate and advanced chronic kidney disease
    Csaba P Kovesdy
    Salem VA Medical Center, Salem, VA 24153, USA
    Am J Clin Nutr 90:407-14. 2009
    ..Markers of protein-energy wasting (PEW) and inflammation are common in chronic kidney disease (CKD) and are among the strongest predictors of mortality in dialysis patients...
  83. ncbi Superior serum half life of albumin tagged TNF ligands
    Nicole Muller
    Division of Molecular Internal Medicine, Department of Internal Medicine II, University Hospital Wurzburg, Rontgenring 11, 97070 Wurzburg, Germany
    Biochem Biophys Res Commun 396:793-9. 2010
    ..the TNF family members TNF, TWEAK and TRAIL, we genetically fused soluble variants of these molecules to human serum albumin (HSA)...
  84. ncbi Predicting plasma protein binding of drugs: a new approach
    Nicole A Kratochwil
    Chemical Technologies, F Hoffmann La Roche, CH 4070, Basel, Switzerland
    Biochem Pharmacol 64:1355-74. 2002
    ..We present here an extensive list of multiply determined primary association constants for binding to human serum albumin (HSA) for 138 compounds from the literature...
  85. ncbi The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates
    Peter Caravan
    EPIX Medical, Inc, 71 Rogers Street, Cambridge, MA 02142 1118, USA
    J Am Chem Soc 124:3152-62. 2002
    ..MS-325 functions by binding to human serum albumin (HSA) in plasma...
  86. ncbi Simple surrogate index of the fibrosis stage in chronic hepatitis C patients using platelet count and serum albumin level
    Takeyuki Ohta
    Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
    Acta Med Okayama 60:77-84. 2006
    ..7% and 75.0% in the initial cohort and 70.8% and 81.0% in the validation cohort. The fibrosis index comprised of platelet count and albumin level reflected the histological fibrosis stage in patients with chronic hepatitis C...
  87. ncbi Fluorescence spectral resolution of tryptophan residues in bovine and human serum albumins
    Nadim Tayeh
    Laboratoire de Biophysique Moleculaire, Universite des Sciences et Technologies de Lille, Bâtiment C6, 59655 Villeneuve d Ascq cedex, France
    J Pharm Biomed Anal 50:107-16. 2009
    ....
  88. ncbi Albumin binding to FcRn: distinct from the FcRn-IgG interaction
    Chaity Chaudhury
    Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 45:4983-90. 2006
    ..Our results suggest that the FcRn-albumin interaction has unique features distinct from FcRn-IgG binding despite the overall similarity in the pH-dependent binding mechanism by which both ligands are protected from degradation...
  89. ncbi Effect of albumin conformation on the binding of ciprofloxacin to human serum albumin: a novel approach directly assigning binding site
    Basir Ahmad
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh U P, India 202002
    Biomacromolecules 7:1350-6. 2006
    Human serum albumin (HSA) is known to exist as N (pH approximately 7), B (pH approximately 9), and F (pH approximately 3...
  90. pmc Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin
    D Roy
    Heart 92:113-4. 2006
  91. pmc Glycemic control and extended hemodialysis survival in patients with diabetes mellitus: comparative results of traditional and time-dependent Cox model analyses
    Mark E Williams
    Renal Unit, Joslin Diabetes Center, Boston, MA 02215, USA
    Clin J Am Soc Nephrol 5:1595-601. 2010
    ..Recent large observational studies with differing methodologies reached somewhat contrasting conclusions regarding the association of hemoglobin A1c with survival in diabetic chronic hemodialysis patients...
  92. ncbi Effect of Chinese medicine alpinetin on the structure of human serum albumin
    Wenying He
    Department of Chemistry, Lanzhou University, Lanzhou 730000, China
    Bioorg Med Chem 13:1837-45. 2005
    ..In this paper, the interaction of alpinetin to human serum albumin (HSA) has been studied for the first time by spectroscopic method including Fourier transform infrared (FT-IR) ..
  93. ncbi Dendrimers bind human serum albumin
    E Froehlich
    Departement de Chimie Biologie, Universite du Quebec a Trois Rivieres, C P 500, Trois Rivieres, Quebec, G9A 5H7, Canada
    J Phys Chem B 113:6986-93. 2009
    ..Human serum albumin (HSA) is a major transporter for delivering several endogenous compounds and drugs in vivo...
  94. pmc The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade
    Jeffrey S Scehnet
    Department of Pathology, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Blood 113:254-63. 2009
    ..studied the biologic effects of blocking EphrinB2 using the extracellular domain of EphB4 fused with human serum albumin (sEphB4-HSA)...
  95. ncbi Proteomic profiling identifies afamin as a potential biomarker for ovarian cancer
    David Jackson
    Cancer Research UK Clinical Centre, St James s University Hospital, Leeds, United Kingdom
    Clin Cancer Res 13:7370-9. 2007
    ..To discover and validate serum glycoprotein biomarkers in ovarian cancer using proteomic-based approaches...
  96. ncbi Structural analysis of human serum albumin complexes with cationic lipids
    David Charbonneau
    Departement de Chimie Biologie, Universite du Quebec a Trois Rivieres, C P 500, Trois Rivieres, Quebec, G9A 5H7, Canada
    J Phys Chem B 113:1777-84. 2009
    Human serum albumin (HSA) is a major transporter for delivering several endogenous compounds including fatty acids in vivo...
  97. ncbi Gp60 activation mediates albumin transcytosis in endothelial cells by tyrosine kinase-dependent pathway
    C Tiruppathi
    Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Illinois 60612 7343, USA
    J Biol Chem 272:25968-75. 1997
    ..These findings indicate that activation of gp60 stimulates the Src PTK signaling pathway, and thus regulates the transcytosis of albumin across the endothelial cell monolayer...
  98. ncbi Enhanced uptake of lactosaminated human albumin by rat hepatocarcinomas: implications for an improved chemotherapy of primary liver tumors
    Giuseppina Di Stefano
    Department of Experimental Pathology, University of Bologna, Italy
    Liver Int 25:854-60. 2005
    ..The aim of the present experiments was to ascertain whether ASGP-R of HCCs is functionally active and these tumors can internalize higher quantities of MEGRs than extra-hepatic tissues...
  99. ncbi Increased serum albumin, gamma globulin, immunoglobulin IgG, and IgG2 and IgG4 in autism
    J Croonenberghs
    University Center of Child and Adolescent Psychiatry, A Z M and Department of Medical Biochemistry, University of Antwerp, Wilrijk, Clinical Laboratory A Z Middelheim, Antwerp, The Netherlands
    Psychol Med 32:1457-63. 2002
    ..As a consequence we expected to find that autism is accompanied by abnormalities in the pattern obtained in serum protein electrophoresis and in the serum immunoglobulin (Ig) and IgG subclass profile...
  100. ncbi Highly specific HER2-mediated cellular uptake of antibody-modified nanoparticles in tumour cells
    Heidrun Wartlick
    Institute for Pharmaceutical Technology, Biocenter of Johann Wolfgang Goethe University, Marie Curie Strasse 9, D 60439 Frankfurt, Germany
    J Drug Target 12:461-71. 2004
    ..In the present study biodegradable nanoparticles based on gelatin and human serum albumin (HSA) were developed...
  101. ncbi Bacterial adherence to titanium surface coated with human serum albumin
    Teemu J Kinnari
    Department of Otolaryngology, Helsinki University Central Hospital, Helsinki, Finland
    Otol Neurotol 26:380-4. 2005
    ..An albumin coating on titanium implants will inhibit bacterial adhesion on the implant surface...

Research Grants64

  1. THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
    Joseph Eustace; Fiscal Year: 2004
    ..in one arm of the trial the efficacy of oral essential amino acids supplements versus placebo at improving serum albumin levels and reducing hospitalization rates and (1C) Use a decision analysis model to compare the cost-..
  2. IMMUNOLOGICAL ASPECTS OF HEMORRHAGE
    Irshad H Chaudry; Fiscal Year: 2010
    ..Furthermore, we will use E2 (cell permeable) and E2 conjugated with BSA (bovine serum albumin;cell impermeable) to determine the contribution of nuclear vs...
  3. Hospital and Household Studies of Respiratory Cryptosporidiosis and Transmission
    Jeffrey K Griffiths; Fiscal Year: 2013
    ..grown in vitro. Nutritional status will be gauged via anthropometrics, hemoglobin, and serum albumin. HIV testing, if consented to, will be performed. Sputum isolates of Cr. will be speciated via RFLP analysis...
  4. Health Information Technology for Chronic Kidney Disease Management
    Lipika Samal; Fiscal Year: 2013
    ..Develop a search method to find existing urine albumin to creatinine ratio, serum calcium, serum phosphate, serum albumin, and serum bicarbonate values...
  5. Gonococcal resistance to peroxynitrite
    Virginia L Clark; Fiscal Year: 2010
    ..oxidation of dihydrorhodamine and DNA, and the ability to remove nitro- groups from nitrated bovine serum albumin. Successful completion of this project will identify novel genes involved in resistance to peroxynitrite in ..
  6. Phosphorylation Events During Sperm Capacitation
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
    ..phosphorylation as well as capacitation was regulated by the presence of cholesterol acceptors such as Bovine Serum Albumin (BSA) in the capacitation media...
  7. Alkylammonium Formate Mobile Phase Modifiers for Protein Liquid Chromatography
    NEIL DANIELSON; Fiscal Year: 2009
    ..can be used to study the tertiary and secondary structures of model proteins such as cytochrome c, bovine serum albumin, and lysozyme in these ionic liquids...
  8. Integrating plasma IGF-1 into novel classification of hepatocellular carcinoma
    Ahmed Kaseb; Fiscal Year: 2013
    ..variables: three objective laboratory-based parameters that assess the synthetic function of the liver through serum albumin level and prothrombin time or the elimination function of the liver through measuring serum bilirubin level, ..
  9. Development of Human Asparaginase for Cancer Therapy
    Arnon Lavie; Fiscal Year: 2013
    ..An additional novel aspect of Aim 2 is the linking f the human asparaginase to human serum albumin (HSA)...
  10. A NOVEL STRATEGY FOR THE TREATMENT OF MELANOMA
    Mai Xu; Fiscal Year: 2013
    ..specifically using hyperthermia to modulate the delivery of the FDA approved anticancer drug Abraxane (human serum albumin (HSA) based paclitaxel-nanoparticle) to tumors...
  11. Molecular Combinatorial Therapy of Glioblastoma Multiforme
    Waldemar Debinski; Fiscal Year: 2013
    ..to recombinant cytotoxins'delivery to GBM, it was demonstrated that using gadolinium and labeled human serum albumin (HSA) a faithful monitoring of drug distribution through CED can be obtained...
  12. TGF-beta Mediated Inflammatory Signaling: a Critical Role in Epileptogenesis
    Daniela Kaufer; Fiscal Year: 2012
    ..leads to the development of focal epileptiform activity, similar to that observed following injury, and that serum albumin is a critical factor in subsequent epileptogenesis...
  13. Assay for Monitoring Glycemic Control in Diabetics
    Ralph Ballerstadt; Fiscal Year: 2010
    ..g. hemoglobin HbA1c, IgM, IgG, serum albumin, and fibrinogen), followed by fluorescence detection using a microplate reader...
  14. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2013
    ..bilirubin is a measure of the capacity to sequester bilirubin in the blood compartment by its binding to serum albumin. The concentration of unbound bilirubin, the driver for bilirubin escaping from the vasculature, can be ..
  15. Development of a Peptidomic Rapid Point-of-Care TB Diagnostic
    RAYMOND SAM NIEDBALA; Fiscal Year: 2013
    ..STTR, deTect focused on a subset of nine peptides, optimized methods for conjugating these peptides to bovine serum albumin (BSA), and demonstrated that the peptide-BSA conjugates resulted in significantly enhanced reactivity (..
  16. Point-of Care System for Determination of Bilirubin Capacity in Neonates
    GLEN D RAMSAY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Human serum albumin is capable of binding bilirubin with high affinity, thus sequestering it and mitigat- ing its harmful neurological effects in jaundiced newborns...
  17. Initiating Events in AMD: a mouse model for the human disease
    JOE GILBERT HOLLYFIELD; Fiscal Year: 2013
    ..To test this hypothesis we immunized normal mice with CEP-adducted mouse serum albumin (CEP-MSA)...
  18. Using natural antibodies to improve vaccines
    JOHN J IACOMINI; Fiscal Year: 2013
    ..natural antibodies, to analyze whether conjugation of a poorly immunogenic antigen, such as bovine serum albumin (BSA), to 1Gal could affect its immunogenicity in vivo...
  19. Development of sEphB4-HSA as Novel Therapeutic in Cancer
    VALERY G KRASNOPEROV; Fiscal Year: 2013
    ..We have developed an EphB4-EphrinB2 inhibitor - the extracellular fragment of EphB4 fused with human serum albumin (sEphB4-HSA)...
  20. Contact site mapping of transient protein-protein complexes at the molecular leve
    Yumei Huang; Fiscal Year: 2012
    ..using model peptides as substrates, (b) purification/enrichment methods will be developed using bovine serum albumin (BSA) with reversible linkage as a model system, (c) an oxLink" set will be synthesized, and (d) the MS ..
  21. Biological Response Indicators of Environment Stress Centers
    STEPHEN MORRIS RAPPAPORT; Fiscal Year: 2011
    ..We propose to enrich unknown cysteinyl adducts of human serum albumin and then to profile these adducts in the serum of lymphoma cases and controls...
  22. Obesity and Surgical Outcomes
    Jeffrey H Silber; Fiscal Year: 2010
    ..1) a three state, 50 hospital, Medicare "augmented claims analysis" that includes height, weight, and serum albumin information from charts (N=20,000), and (2) a nested, detailed chart abstraction (N=4000) using a matched ..
  23. Nanoparticles in the Human Placenta:Toxicokinetics
    RICHARD KERMIT MILLER; Fiscal Year: 2010
    ..circuit by the perfused human placenta in vitro using 5 nm gold (Au) particles coated with human F105 IgG or serum albumin, SPECIFIC AIM 2: Determine if larger NPs transit from the maternal to fetal circuits under perfusion ..
  24. Nephrotic Syndrome, Cardiovascular Disease Risk and the Effect of Statin Therapy
    Laura H Mariani; Fiscal Year: 2012
    ..The syndrome is characterized by significant proteinuria, low serum albumin, edema and hyperlipidemia...
  25. Proteome and Transcriptome Markers of Hypertension in Urine and Plasma Exosomes
    Kevin L Schey; Fiscal Year: 2010
    ..discovery in plasma samples is the well known dynamic range issue where highly abundant proteins such as serum albumin are 1010 times more abundant than the least concentrated, perhaps most important, marker proteins...
  26. Development of At-211-Labeled Reagents for Therapy of Metastatic Prostate Cancer
    DANIEL SCOTT WILBUR; Fiscal Year: 2013
    ..In specific aim 3, the same molecules used in SA1 and SA2 will be conjugated with recombinant human serum albumin (rHSA) to provide 211At-labeled reagents that will be excluded from kidney, but will also have low ..
  27. Altered synaptogenesis after albumin exposure: A model for post traumatic epilep
    Lydia J Wood; Fiscal Year: 2012
    ..It is already known that central nervous system exposure to serum albumin via a penetrating head injury can lead to downstream perilesional hyperxcitability and seizures...
  28. Building Disease Prediction Models by Synthesis Analysis
    XIAO HUA A ZHOU; Fiscal Year: 2010
    ..Therefore, new risk factors such as serum albumin, homocysteine, C-reactive protein...
  29. The Comprehensive Discovery and Assay of the Human Proteome
    PAUL contact STROOBANT; Fiscal Year: 2010
    ..novel plasma proteins has been the approximately 10 orders of magnitude relative abundance difference between serum albumin (35-50 x 109 pg/ml) and low abundance proteins such as Interleukin-6 (0-5 pg/ml)...
  30. Improved Tools for Expression of Recombinant Genes in the Yeast Pichia pastoris
    JAMES MICHAEL CREGG; Fiscal Year: 2012
    ..with over five thousand publications on its use and at least two human biopharmaceuticals (human serum albumin and ecallantide) on the market in the US and others at various stages in the clinical trial pipeline...
  31. Universal Protein Carrier Scaffold for Small Molecules and Peptide Therapeutics
    DAVID IAN RABUKA; Fiscal Year: 2010
    ..Redwood Bioscience's aldehyde-tag technology can be applied to create modified human serum albumin proteins...
  32. Nanoplatform-based combinational therapy against breast cancer
    Jin Xie; Fiscal Year: 2013
    ..seeks to meet the challenge through a nanoplatform that we recently developed, which is comprised of a human serum albumin (HSA) coating, an amine-rich intermediate coating, and an iron oxide nanoparticle (lONP) core...
  33. Neuroprotection by Docosahexaenoic Acid-Albumin in Experimental Stroke
    Ludmila S Belayev; Fiscal Year: 2013
    ..Recently, we have established that human serum albumin (Alb) complexed to the omega-3 fatty acid docosahexaenoic acid (DHA, 22:6n-3) may be equally efficacious or ..
  34. Solid state synthesis and applications of oligo(phenylene-ethynes)
    Wei Chu Xu; Fiscal Year: 2010
    ..In order to assess their potential utility, one oligomer will be conjugated to the drug- binding protein human serum albumin (HSA), and the interaction of the construct with typical drugs will be measured by observing changes in ..
  35. COMPETITION FOR HEME AMONG PERIODONTAL BACTERIA
    GEOFFREY TOMPKINS; Fiscal Year: 1993
    ..gingivalis. The assay will be modified to examine the influence of the specific heme- binding proteins, human serum albumin and human hemopexin, on bacterial heme-acquisition...
  36. Retrospective Cyanide Assay from a Unique HSA-CN Adduct
    Kenneth M Aldous; Fiscal Year: 2010
    ..studies by us showed that CN reacts with several susceptible disulfide bonds in immunoglobulin (IgG) and human serum albumin (HSA) to form SCN adducts on one of the Cys components...
  37. ALCOHOL AND LIVER ENDOTHELIAL CELLS IN IMMUNE RESPONSES
    Geoffrey Thiele; Fiscal Year: 1999
    ..the effect of ethanol administration on RME by various scavenger receptors for; formaldehyde treated bovine serum albumin (f- Alb), nonenzymatically glycosylated bovine serum albumin (AGE-Alb), acetylated low density lipoproteins (A-..
  38. HYPOTHALAMIC OPIATES IN OBESITY-ACCELERATED HYPERTENSION
    Robin Rockhold; Fiscal Year: 1991
    ..obesity-accelerated hypertension will be identified by measuring alterations in plasma volume (radio-iodinated serum albumin dilution) and baroreflex sensitivity in conscious, unrestrained rats following chronic (2 month) changes in ..
  39. Protein Stabilization in Ionic Liquids
    Gloria Elliott; Fiscal Year: 2009
    ..Aim #2: To identify the most solubilizing ILs for cytochrome C, lysozyme, and bovine serum albumin from the subset of ILs prioritized in Aim #1...
  40. Silicone-free glass pre-filled syringe system for Biological Drugs.
    VINAY SAKHRANI; Fiscal Year: 2009
    ..The proteins selected for this study are human serum albumin, human IgG, insulin, and abatecept (monoclonal antibody by Bristol Myers Squibb)...
  41. HEME PROTEINS, MICROSPHERES AND SYNTHETIC ANALOGS
    KENNETH SUSLICK; Fiscal Year: 2004
    ..In related work, it has been discovered that ultrasonic irradiation of various proteins (e.g., hemoglobin and serum albumin) creates micron-sized spheres...
  42. Biomarkers for exposure to Stachybotrys
    Dorr Dearborn; Fiscal Year: 2007
    ..satratoxin G, a macrocyclic trichothecene from Stachybotrys with 2 epoxides, forms stable adducts with human serum albumin. This offers the potential for quantitative biomarker 'dosimeters' in the form of protein adducts ..
  43. CARHOHYDRATE MOIETIES OF GP120
    Khushi Matta; Fiscal Year: 1993
    ..an aglycon which can serve as a bridge for attachment to high molecular weight substances such as bovine serum albumin. Complex structures containing mannose is one of our major interests in this program...
  44. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..In contrast albumin synthesis and serum albumin increase promptly when patients are fed following starvation, suggesting that malnutrition may not be the ..
  45. CONTROL OF HUMAN MUSCLE CELL GROWTH AND DIFFERENTIATION
    RICHARD HAM; Fiscal Year: 1991
    ..of optimize nutrient medium MCDB 120 plus epidermal growth factor (EGF), dexamethasone, insulin, fetuin, and serum albumin, will be used as the starting point for these studies...
  46. Recombinant human serum albumin for use in cell culture media
    Ning Huang; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Plasma-derived human serum albumin (pHSA) or bovine serum albumin are commonly added to cell culture media used in cell culture-based vaccine and therapeutic production, because it ..
  47. ACID/BASE TRANSPORT THROUGH LIPID BILAYER MEMBRANES
    JOHN GUTKNECHT; Fiscal Year: 1993
    ..the pH dependence, the voltage dependence, the dependence upon membrane thickness and the effects of serum albumin. The data from both groups of experiments will be used to predict proton conductances and weak acid transport ..
  48. EFFECTS OF AGING ON DELAYED HYPERSENSITIVITY IN MICE
    ALFRED CROWLE; Fiscal Year: 1980
    A/Jax female mice have been immunized with chicken conalbumin or methylated human serum albumin in Freund adjuvant at three-month intervals in a two-year period of aging (to 1...
  49. PH CONTROL OF PROTEIN SYNTHESIS
    Peter Garlick; Fiscal Year: 2003
    ..and respiratory acidosis are associated with depressed rates of synthesis of skeletal muscle protein and serum albumin. The purpose of the present proposal is therefore to characterize the relationship between protein synthesis ..
  50. HEPATIC PATHWAYS OF HEME AND BILIRUBIN METABOLISM
    John Gollan; Fiscal Year: 1999
    ..molecules to the bLPM, the contribution of circulating lipid assemblies (HDL, LDL, erythrocyte membranes) and serum albumin will be investigated. The kinetics of intermembrane (bLPM to E.R...
  51. Assessing Functional Outcomes in Adolescent with ESRD
    Susan Furth; Fiscal Year: 2002
    ..Furth to examine the link between clinical measures such as hematocrit, serum albumin, and dialysis adequacy (Kt/V) and functional outcome/HRQL...
  52. IMMUNOTOXICITY OF ACID ANHYDRIDES IN THE LUNG
    JEAN REGAL; Fiscal Year: 1999
    ..Animals will be sensitized ID with TMA and 3 wk later challenged intratracheally with antigen (TMA coupled to serum albumin)...
  53. OVERALL HEMOCOMPATIBILITY PEO-FUNCTIONALIZED SILOXANES
    William Collins; Fiscal Year: 2003
    ..Fibrinogen and vitronectin will be isolated from citrated human blood plasma. Human serum albumin will be used as a control...
  54. OVERALL HEMOCOMPATIBILITY PEO-FUNCTIONALIZED SILOXANES
    William Collins; Fiscal Year: 2001
    ..Fibrinogen and vitronectin will be isolated from citrated human blood plasma. Human serum albumin will be used as a control...
  55. Benzo[i]phenanthridines: TOP1-Targeting Antitumor Agents
    EDMOND LAVOIE; Fiscal Year: 2006
    ..of this alkaloid, the metabolic instability of its lactone moiety and the high binding affinity to human serum albumin of its hydrolysis product are among the obstacles that hampered clinical development of this first generation ..
  56. CHEMICALLLY INDUCED CHRONIC ALLERGIC LUNG DISEASE
    MERYL KAROL; Fiscal Year: 2000
    ..Specific Aim 1 is to identify the in vitro chemical adducts and adduction sites of TDI on serum albumin (SA), and on hemoglobin (Hb), two proteins which in guinea pigs have been shown to bear adduct following ..
  57. MIMICS OF SUPEROXIDE DISMUTASE--ISOLATION & SYNTHESIS
    Irwin Fridovich; Fiscal Year: 1990
    ..systems, they are of little use in biological systems because a variety of proteins, including serum albumin, can strip them of their Cu(II) and thus inactivate them...
  58. B Cell Repertoire and B cell Neoplasms in Old Mice
    MARC WEKSLER; Fiscal Year: 2006
    ..plasma cells after the appearance of antigen-specific mlg or diffuse large cell lymphoma (DLCL) from DNP-human serum albumin (DNP-HSA)- or hen egg lysozyme (HEL)-immunized C57/BL/6 mice...
  59. MORTALITY & MORBIDITY IN HEMODIALYSIS PATIENTS
    John Daugirdas; Fiscal Year: 2001
    ..for cardiovascular disease, infection, or other non-access-related causes, declining body weight, or declining serum albumin level) in patients randomly assigned to one of four groups: (A) moderate-dose dialysis, low-flux cellulose ..
  60. NOVEL CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING
    Brian Gray; Fiscal Year: 1999
    ..Binding of magnetically active small molecules to human serum albumin (HSA) through interaction of alkyl "tails" with binding sites on HSA should allow tailoring of blood pool half-..
  61. IMMUNOPATHOGEN. OF OCCUP. DIS. DUE TO REACT. CHEMICALS
    David Bernstein; Fiscal Year: 1991
    ..Only a minority of such cases have been associated with IgE responses to diisocyanate human serum albumin (HSA) conjugates...
  62. MICROFABRICATED MICRONEEDLES FOR DRUG DELIVERY
    MARK PRAUSNITZ; Fiscal Year: 2003
    ..in vitro by up to five orders of magnitude for small molecules (calcein), macromolecules (insulin, bovine serum albumin) and nanospheres (100 nm diameter)...
  63. MICROFABRICATED MICRONEEDLES FOR DRUG DELIVERY
    MARK PRAUSNITZ; Fiscal Year: 2001
    ..in vitro by up to five orders of magnitude for small molecules (calcein), macromolecules (insulin, bovine serum albumin) and nanospheres (100 nm diameter)...
  64. REGULATION OF ALPHA-FETOPROTEIN GENE EXPRESSION
    Shirley Tilghman; Fiscal Year: 1993
    ..In contrast, serum albumin, which is the major serum protein synthesized by the adult liver, increases from low levels early in ..