ovalbumin

Summary

Summary: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.

Top Publications

  1. pmc Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    Wanjun Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1875-86. 2003
  2. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
  3. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
  4. ncbi Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
    Sven Burgdorf
    Institute of Molecular Medicine and Experimental Immunology, Friedrich Wilhelms University, 53105 Bonn, Germany
    Nat Immunol 9:558-66. 2008
  5. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
  6. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
  7. pmc In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    Laura C Bonifaz
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:815-24. 2004
  8. ncbi The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation
    Sven Burgdorf
    Institute of Molecular Medicine and Experimental Immunology IMMEI, Friedrich Wilhelms Universität, Bonn, Germany
    J Immunol 176:6770-6. 2006
  9. pmc Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:1149-66. 2009
  10. pmc Pulmonary arterial remodeling induced by a Th2 immune response
    Eleen Daley
    St Luke s Roosevelt Hospital, New York, NY 10019, USA
    J Exp Med 205:361-72. 2008

Detail Information

Publications391 found, 100 shown here

  1. pmc Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    Wanjun Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 198:1875-86. 2003
    ..More importantly, in an ovalbumin peptide TCR transgenic adoptive transfer model, TGF-beta-converted transgenic CD4+CD25+ suppressor cells ..
  2. ncbi Interleukin-13: central mediator of allergic asthma
    M Wills-Karp
    Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    Science 282:2258-61. 1998
    ..Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses...
  3. pmc Requirement for IL-13 independently of IL-4 in experimental asthma
    G Grunig
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94143, USA
    Science 282:2261-3. 1998
    ..This pathway may underlie the genetic associations of asthma with both the human 5q31 locus and the IL-4 receptor...
  4. ncbi Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
    Sven Burgdorf
    Institute of Molecular Medicine and Experimental Immunology, Friedrich Wilhelms University, 53105 Bonn, Germany
    Nat Immunol 9:558-66. 2008
    ..Thus, cross-presentation is spatially and mechanistically separated from endogenous MHC class I-restricted antigen presentation and is biased toward antigens containing microbial molecular patterns...
  5. ncbi Help for cytotoxic-T-cell responses is mediated by CD40 signalling
    S R Bennett
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, PO The Royal Melbourne Hospital, Victoria, Australia
    Nature 393:478-80. 1998
    ....
  6. pmc Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    Laura Bonifaz
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 196:1627-38. 2002
    ..b>Ovalbumin (OVA) protein, when chemically coupled to monoclonal alphaDEC-205 antibody, was presented by CD11c+ lymph node ..
  7. pmc In vivo targeting of antigens to maturing dendritic cells via the DEC-205 receptor improves T cell vaccination
    Laura C Bonifaz
    Laboratory of Cellular Physiology and Immunology, Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 199:815-24. 2004
    ..To assess the potential of antigen targeting to dendritic cells to improve immunity, we incorporated ovalbumin protein into a monoclonal antibody to the DEC-205 receptor, an endocytic receptor that is abundant on these ..
  8. ncbi The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation
    Sven Burgdorf
    Institute of Molecular Medicine and Experimental Immunology IMMEI, Friedrich Wilhelms Universität, Bonn, Germany
    J Immunol 176:6770-6. 2006
    ..Uptake of cell-associated OVA was unaffected by MR deficiency, resulting in unchanged activation of OT-I cells. These findings demonstrate that DC use the MR for endocytosis of a particular Ag type intended for cross-presentation...
  9. pmc Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 206:1149-66. 2009
    ..These studies establish novel regulatory roles for BRP-39/YKL-40 in the initiation and effector phases of Th2 inflammation and remodeling and suggest that these proteins are therapeutic targets in Th2- and macrophage-mediated disorders...
  10. pmc Pulmonary arterial remodeling induced by a Th2 immune response
    Eleen Daley
    St Luke s Roosevelt Hospital, New York, NY 10019, USA
    J Exp Med 205:361-72. 2008
    ....
  11. ncbi Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation
    Yves Delneste
    Centre d Immunologie Pierre Fabre, 5 Avenue Napoleon III, Saint Julien en Genevois, France
    Immunity 17:353-62. 2002
    ..In vivo, to target LOX-1 with a tumor antigen using an anti-LOX-1 mAb induces antitumor immunity. Thus, the scavenger receptor LOX-1 is certainly a promising target for cancer immunotherapy...
  12. pmc Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors
    D Avram
    Laboratory of Molecular Pharmacology, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA
    J Biol Chem 275:10315-22. 2000
    ..proteins 1 and 2, respectively), were isolated and shown to interact with all members of the chicken ovalbumin upstream promoter transcription factor (COUP-TF) subfamily of orphan nuclear receptors...
  13. pmc Defective CD8 T cell memory following acute infection without CD4 T cell help
    Joseph C Sun
    Department of Immunology and the Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    Science 300:339-42. 2003
    ..The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development...
  14. pmc Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
    L S Cardoso
    Servico de Imunologia, Hospital Universitario Prof Edgard Santos, Universidade Federal da Bahia, Salvador, BA, Brazil
    Clin Exp Immunol 160:266-74. 2010
    ..We evaluated the immune response induced by the S. mansoni antigens Sm22.6, PIII and Sm29 in a murine model of ovalbumin (OVA)-induced airway inflammation...
  15. ncbi Defining a link with asthma in mice congenitally deficient in eosinophils
    James J Lee
    Division of Pulmonary Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA
    Science 305:1773-6. 2004
    ..The development of an eosinophil-less mouse now permits an unambiguous assessment of a number of human diseases that have been linked to this granulocyte, including allergic diseases, parasite infections, and tumorigenesis...
  16. pmc Oral tolerance in the absence of naturally occurring Tregs
    Daniel Mucida
    Program of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Clin Invest 115:1923-33. 2005
    ..However, unlike oral administration of antigen, which induced Tregs but not effector T cells, i.p. immunization led to the simultaneous induction of Tregs and effector Th2 cells displaying the same antigen specificity...
  17. pmc Adverse effect of nano-silicon dioxide on lung function of rats with or without ovalbumin immunization
    Bing Han
    Laboratory of Environmental Sciences and Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Huazhong Normal University, Wuhan, China
    PLoS ONE 6:e17236. 2011
    ..For the first time, this work investigates the relationship between allergic asthma and nanosized silicon dioxide (nano-SiO₂)...
  18. ncbi Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals
    Go Takayama
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    J Allergy Clin Immunol 118:98-104. 2006
    ..We have previously identified the POSTN gene encoding periostin as an IL-4/IL-13-inducible gene in bronchial epithelial cells. Periostin is thought to be an adhesion molecule because it possesses 4 fasciclin I domains...
  19. ncbi Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo
    K M Murphy
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Science 250:1720-3. 1990
    ..Apoptosis of cortical thymocytes can be seen within 20 hours of treatment. These results provide direct evidence for the in vivo role of apoptosis in the development of antigen-induced tolerance...
  20. pmc Constitutive versus activation-dependent cross-presentation of immune complexes by CD8(+) and CD8(-) dendritic cells in vivo
    Joke M M den Haan
    Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195 7370, USA
    J Exp Med 196:817-27. 2002
    ..We previously demonstrated that, when cell-associated ovalbumin (OVA) is injected into mice, only the CD8(+) DC subset cross-presents OVA in the context of MHC class I...
  21. ncbi Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway
    Fabien Schmidlin
    Department of Surgery and Physiology, University of California, San Francisco 94143, USA
    J Immunol 169:5315-21. 2002
    ..Thus, PAR2 contributes to the development of immunity and to allergic inflammation of the airway. Our results support the proposal that tryptase inhibitors and PAR2 antagonists may be useful therapies for inflammatory airway disease...
  22. ncbi Preferential localization of effector memory cells in nonlymphoid tissue
    D Masopust
    Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 291:2413-7. 2001
    ..These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection...
  23. ncbi Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Ibaraki, Japan
    Toxicol Appl Pharmacol 237:306-16. 2009
    ..In vivo, ICR mice were divided into 4 experimental groups. Vehicle, MWCNT (50 microg/animal), ovalbumin (OVA), and OVA+MWCNT were repeatedly administered intratracheally...
  24. pmc Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
    P S Foster
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Exp Med 183:195-201. 1996
    ..Sensitization and aerosol challenge of mice with ovalbumin results in airways eosinophilia and extensive lung damage analogous to that seen in asthma...
  25. pmc Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model
    Tracey L Bonfield
    Dept of Pediatrics, Case Western Reserve Univ, Cleveland, OH 44106 4948, USA
    Am J Physiol Lung Cell Mol Physiol 299:L760-70. 2010
    ..effectiveness and specificity of the hMSCs on decreasing chronic airway inflammation associated with the murine ovalbumin model of asthma...
  26. pmc Coexpression of GM-CSF and antigen in DNA prime-adenoviral vector boost immunization enhances polyfunctional CD8+ T cell responses, whereas expression of GM-CSF antigen fusion protein induces autoimmunity
    Matthias Tenbusch
    Department of Molecular and Medical Virology, Ruhr University Bochum, 44801 Bochum, Germany
    BMC Immunol 9:13. 2008
    ..on antigen-presenting cells enhances antigen-specific CD8 T-cell responses, fusion proteins of GM-CSF and ovalbumin (OVA) were expressed by DNA and adenoviral vector vaccines...
  27. ncbi Introduction of soluble protein into the class I pathway of antigen processing and presentation
    M W Moore
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037
    Cell 54:777-85. 1988
    ..C57BL/6 (H-2b) mice immunized against a syngeneic tumor cell transfected with chicken ovalbumin (OVA) cDNA gave rise to H-2Kb-restricted CTL specific for the OVA258-276 peptide...
  28. ncbi Panax ginseng ameliorates airway inflammation in an ovalbumin-sensitized mouse allergic asthma model
    Dae Yong Kim
    Department of Pharmacology, Sungkyunkwan University School of Medicine, 300 Chunchun dong, Jangan ku, Suwon 440 746, Republic of Korea
    J Ethnopharmacol 136:230-5. 2011
    ..Panax ginseng (PG) is a medicinal herb that has been used to treat various immune diseases including asthma and COPD. In this study, we investigated the inhibitory mechanism of PG on asthma parameters in mice...
  29. ncbi Involvement of distal airways in a chronic model of experimental asthma
    M Wegmann
    Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University, Marburg, Germany
    Clin Exp Allergy 35:1263-71. 2005
    ..Bronchial asthma is characterized by chronic airway inflammation and airway remodelling which occurs in both proximal and distal airways. These changes are associated with development of airway hyper-responsiveness and airflow limitation...
  30. ncbi Increased arginase activity contributes to airway remodelling in chronic allergic asthma
    H Maarsingh
    Department of Molecular Pharmacology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Eur Respir J 38:318-28. 2011
    ..b>Ovalbumin-sensitised guinea pigs were treated with ABH or PBS via inhalation before each of 12 weekly allergen or saline ..
  31. ncbi Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin
    Chan Hun Jung
    Division of Pathophysiology and Pharmacology, College of Pharmacy, Chung Ang University, Seoul 156 756, Korea
    Arch Pharm Res 30:1599-607. 2007
    The effects of quercetin and rutin on the asthmatic responses were studied in ovalbumin (OA)-sensitized conscious guinea pigs challenged with aerosolized-OA...
  32. pmc Acinetobacter baumannii infection inhibits airway eosinophilia and lung pathology in a mouse model of allergic asthma
    Hongyu Qiu
    Institute for Biological Sciences, National Research Council Canada, Ottawa, Ontario, Canada
    PLoS ONE 6:e22004. 2011
    ..baumannii in modulating airway eosinophilia in a mouse model of allergic asthma. Ovalbumin (OVA)-sensitized mice were treated with live A...
  33. ncbi Toll-like receptor 4 agonists adsorbed to aluminium hydroxide adjuvant attenuate ovalbumin-specific allergic airway disease: role of MyD88 adaptor molecule and interleukin-12/interferon-gamma axis
    J Bortolatto
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Clin Exp Allergy 38:1668-79. 2008
    ....
  34. ncbi Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8- dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells
    J L Pooley
    Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    J Immunol 166:5327-30. 2001
    ..This differential persisted when the DC were activated with LPS. The CD8(+) DC are therefore specialized for in vivo cross-presentation of exogenous soluble Ags into the class I MHC presentation pathway...
  35. ncbi Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice
    Unni C Nygaard
    Division of Environmental Medicine, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Toxicol Sci 109:113-23. 2009
    ..mwCNT, as well as ultrafine carbon black particles (ufCBPs, Printex90) during sensitization with the allergen ovalbumin (OVA)...
  36. pmc Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus University Medical Centre, 3015 GD Rotterdam, Netherlands
    J Exp Med 205:869-82. 2008
    ..These findings suggest that alum adjuvant is immunogenic by exploiting "nature's adjuvant," the inflammatory DC through induction of the endogenous danger signal uric acid...
  37. ncbi Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma
    Yoon Keun Kim
    Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Namgu, Pohang, Gyeongbuk, Republic of Korea
    J Immunol 178:5375-82. 2007
    ..These findings suggest that airway exposure levels of LPS induces different forms of asthma that are type 1 and type 2 asthma phenotypes by high and low LPS levels, respectively...
  38. pmc Interleukin-17 is a negative regulator of established allergic asthma
    Silvia Schnyder-Candrian
    Universite d Orleans, Centre National de la Recherche Scientifique CNRS, Molecular Immunology and Embryology, 45071 Orleans, France
    J Exp Med 203:2715-25. 2006
    ..Although it is essential during antigen sensitization to establish allergic asthma, in sensitized mice IL-17 attenuates the allergic response by inhibiting DCs and chemokine synthesis...
  39. ncbi Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age
    S Y Tsai
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocr Rev 18:229-40. 1997
  40. pmc Prolonged allergen challenge in mice leads to persistent airway remodelling
    S J McMillan
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London, UK
    Clin Exp Allergy 34:497-507. 2004
    ..Current animal models of allergen-induced airway inflammation generally concentrate on the acute inflammation following allergen exposure and fail to mimic all of these features...
  41. ncbi Prevention of lung eosinophilic inflammation by oral tolerance
    M Russo
    Departmento de Imunologia, Instituto de Ciencias Biomedicas, ICB III, Universidade de Sao Paulo, SP, Brazil
    Immunol Lett 61:15-23. 1998
    ..In this model, which is further characterized here, mice challenged with ovalbumin (OVA) present an intense and persistent lung eosinophilia, as well as histopathological findings that resemble ..
  42. ncbi A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model
    William R Henderson
    Departments of Medicine and Pathology, University of Washington, Seattle, Washington 98195 6523, USA
    Am J Respir Crit Care Med 165:108-16. 2002
    ..BALB/c mice, after intraperitoneal ovalbumin (OVA) sensitization on Days 0 and 14, received intranasal OVA periodically Days 14-75...
  43. pmc Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation
    B N Lambrecht
    Department of Pulmonary Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands
    J Clin Invest 106:551-9. 2000
    ..b>Ovalbumin-pulsed (OVA-pulsed) or unpulsed myeloid DCs that were injected into the airways of naive mice migrated into the ..
  44. pmc T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production
    Nobuki Hayashi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Proc Natl Acad Sci U S A 104:14765-70. 2007
    We previously reported that ovalbumin (OVA) and IL-18 nasally administered act on memory type T helper (Th)1 cells to induce airway hyperresponsiveness (AHR) and inflammation, which is characterized by peribronchial infiltration with ..
  45. ncbi Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge
    A Kanehiro
    Division of Basic Sciences, Department of Pediatrics and Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Am J Respir Crit Care Med 163:173-84. 2001
    ..To address these issues, mice were sensitized and challenged with ovalbumin (OVA) (primary challenge)...
  46. pmc Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge
    Rui He
    Division of Immunology, Children s Hospital and the Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:15817-22. 2007
    ..Epicutaneous (EC) immunization of mice with ovalbumin (OVA), which causes allergic skin inflammation with many characteristics of the skin lesions of atopic ..
  47. ncbi Hierarchical suppression of asthma-like responses by mucosal tolerance
    Alexandre C Keller
    Department of Immunology, Biomedical Science Institute, University of Sao Paulo, Brazil
    J Allergy Clin Immunol 117:283-90. 2006
    ..Mucosal tolerance can be induced by oral or nasal administration of soluble proteins and results in the suppression of cellular and/or humoral immune responses to the specific antigen...
  48. ncbi Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice
    Akihiro Hasegawa
    Department of Immunology, Graduate School of Medicine, Chiba University, Japan
    J Immunol 176:2546-54. 2006
    ..In the present study, we provide the first evidence indicating that a chromatin-remodeling event in T cells is impaired by aging...
  49. pmc Attenuation of allergic airway inflammation and hyperresponsiveness in a murine model of asthma by silver nanoparticles
    Hee Sun Park
    Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Chungnam National University Medical School, Daejeon, Korea
    Int J Nanomedicine 5:505-15. 2010
    ..We used ovalbumin (OVA)-inhaled female C57BL/6 mice to evaluate the roles of silver nanoparticles and the related molecular ..
  50. ncbi Influence of a cocoa-enriched diet on specific immune response in ovalbumin-sensitized rats
    Teresa Pérez-Berezo
    Department of Physiology, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain
    Mol Nutr Food Res 53:389-97. 2009
    ..article describes the effects of a longer-term cocoa-enriched diet (9 weeks) on the specific immune response to ovalbumin (OVA) in adult Wistar rats...
  51. ncbi Oral tolerance attenuates changes in in vitro lung tissue mechanics and extracellular matrix remodeling induced by chronic allergic inflammation in guinea pigs
    Adriane S Nakashima
    Departamento de Clinica Medica, Faculdade de Medicina da Universidade de Sao Paulo, Av Dr Arnaldo, Sao Paulo SP, Brazil
    J Appl Physiol (1985) 104:1778-85. 2008
    ..Measurements of lung tissue resistance and elastance were obtained before and after both ovalbumin and acetylcholine challenges...
  52. pmc Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma
    Riaz I Zuberi
    Division of Allergy, La Jolla Institute of Allergy and Immunology, San Diego, California, USA
    Am J Pathol 165:2045-53. 2004
    ..Herein, we show, in a murine model of ovalbumin (OVA)-induced asthma that 1) peribronchial inflammatory cells expressed large amounts of galectin-3; 2) ..
  53. pmc Spontaneous airway hyperresponsiveness in estrogen receptor-alpha-deficient mice
    Michelle A Carey
    Division of Intramural Research, NIH NIEHS, Triangle Park, NC 27709, USA
    Am J Respir Crit Care Med 175:126-35. 2007
    ..Airway hyperresponsiveness is a critical feature of asthma. Substantial epidemiologic evidence supports a role for female sex hormones in modulating lung function and airway hyperresponsiveness in humans...
  54. ncbi Allergic airway inflammation inhibits pulmonary antibacterial host defense
    Christoph Beisswenger
    Department of Internal Medicine, Division for Pulmonary Diseases, Philipps Universitat Marburg, Germany
    J Immunol 177:1833-7. 2006
    ..These results show that an allergic airway inflammation suppresses the innate antimicrobial host defense. The adaptive immune system modulates the functions of the pulmonary innate immune system...
  55. ncbi Inhibition of chronic airway inflammation and remodeling by galectin-3 gene therapy in a murine model
    Esther Lopez
    Immunology Department, Fundacion Jimenez Diaz Capio, Madrid, Spain
    J Immunol 176:1943-50. 2006
    ..Plasmid-encoding Gal-3 acts as a novel treatment for chronic asthma in mice producing nearly complete blockade of Ag responses with respect to eosinophil airway accumulation, airway hyperresponsiveness, and remodeling...
  56. ncbi CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells
    Maria Luisa del Rio
    Institute of Immunology, Hannover Medical School, Hannover, Germany
    J Immunol 178:6861-6. 2007
    ..Because these cells are largely absent in CCR7(-/-) mice, our findings strongly suggest that brLN CD103(+) DC are lung-derived and that expression of CCR7 is required for their migration from the lung into its draining lymph node...
  57. ncbi Negative feedback between secretory and cytosolic phospholipase A2 and their opposing roles in ovalbumin-induced bronchoconstriction in rats
    Sarit Offer
    Institute of Biochemistry, Faculty of Agriculture, The Hebrew University, Rehovat, Jerusalem
    Am J Physiol Lung Cell Mol Physiol 288:L523-9. 2005
    ..of a cell-impermeable extracellular sPLA2 inhibitor on bronchoconstriction and PLA2 expression in rats with ovalbumin (OVA)-induced asthma...
  58. pmc Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice
    Paula J Busse
    Department of Medicine, Division of Clinical Immunology, Mount Sinai School of Medicine, New York, NY, USA
    Clin Exp Allergy 37:1392-403. 2007
    ..The effect of ageing on several pathologic features of allergic asthma (pulmonary inflammation, eosinophilia, mucus hypersecretion), and their relationship with airway hyperresponsiveness (AHR) is not well characterized...
  59. ncbi Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease
    Irving C Allen
    Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 27599 7264, USA
    Am J Physiol Lung Cell Mol Physiol 291:L1005-17. 2006
    ..This interpretation is supported by high levels of GPRA expression in the brain and its recent identification as the neuropeptide S receptor...
  60. ncbi Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways
    Graeme R Zosky
    Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Australia
    Am J Physiol Lung Cell Mol Physiol 297:L373-9. 2009
    ..was to compare the development of AHR in BALB/c, 129/Sv, and C57BL/6 mice after sensitization and challenge with ovalbumin (OVA)...
  61. ncbi Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF-κB activity
    Mei Yao Wu
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan, 11221
    J Agric Food Chem 59:10496-504. 2011
    ..We found that fisetin attenuated lung inflammation, goblet cell hyperplasia, and airway hyperresponsiveness in ovalbumin-induced asthma and decreased eosinophils and lymphocytes in bronchoalveolar lavage fluid...
  62. ncbi HIF-1α inhibition ameliorates an allergic airway disease via VEGF suppression in bronchial epithelium
    So Ri Kim
    Department of Internal Medicine and Research Center for Pulmonary Disorders, Chonbuk National University Medical School, Jeonju, South Korea
    Eur J Immunol 40:2858-69. 2010
    ....
  63. ncbi Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: Possible role of oxidative stress
    Ken ichiro Inoue
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Free Radic Biol Med 48:924-34. 2010
    ..were divided into four experimental groups that were repeatedly administered vehicle, SWCNT (50 microg/animal), ovalbumin (OVA; an allergen), or OVA + SWCNT through an intratracheal route and thereafter assayed...
  64. pmc Repeated bouts of aerobic exercise enhance regulatory T cell responses in a murine asthma model
    Thomas Lowder
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294 0005, USA
    Brain Behav Immun 24:153-9. 2010
    ..Mice were sensitized with ovalbumin (OVA) prior to the start of exercise training at a moderate intensity 3x/week for 4weeks; exercise was performed ..
  65. ncbi Co-administration of cholera toxin and apple polyphenol extract as a novel and safe mucosal adjuvant strategy
    Naoto Yoshino
    Department of Microbiology, School of Medicine, Iwate Medical University, Morioka, Iwate, Japan
    Vaccine 27:4808-17. 2009
    ..In summary, an optimal dosage of APE would take full advantage of mucosal adjuvanticity of native CT without any toxicity for application in humans...
  66. ncbi A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma
    Laurent L Reber
    Laboratoire d Innovation Therapeutique, Unité Mixte de Recherche 7200, Centre National de la Recherche Scientifique Université de Strasbourg, Faculte de Pharmacie, F 67400 Illkirch, France
    J Immunol 188:3478-87. 2012
    ..In conclusion, we clearly show in this study the anti-inflammatory effect of CpdA in a Th2-driven asthma model in the absence of transactivation, suggesting a potential therapeutic benefit of this strategy...
  67. pmc Anti-inflammatory effects of the R2 peptide, an inhibitor of transglutaminase 2, in a mouse model of allergic asthma, induced by ovalbumin
    Dae Yong Kim
    Department of Pharmacology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea
    Br J Pharmacol 162:210-25. 2011
    ..We examined whether the R2 peptide inhibited the expression of TGase 2 in a mouse model of inflammatory allergic asthma...
  68. ncbi Regulation of IgE responses to inhaled antigen in mice by antigen-specific gamma delta T cells
    C McMenamin
    Division of Cell Biology, Institute for Child Health Research, West Perth, Western Australia
    Science 265:1869-71. 1994
    ..Adoptive transfer of small numbers of gamma delta T cells from ovalbumin (OVA)-tolerant mice selectively suppressed TH2-dependent immunoglobulin E (IgE) antibody production without ..
  69. pmc Requirement for inducible nitric oxide synthase in chronic allergen exposure-induced pulmonary fibrosis but not inflammation
    Amarjit S Naura
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 185:3076-85. 2010
    ..The results in this study exemplify the complexity of the role of iNOS in asthma and the preservation of its potential as a therapeutic a target...
  70. pmc Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice
    C M Williams
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305 5324, USA
    J Exp Med 192:455-62. 2000
    ..We found that genetically mast cell-deficient WBB6F(1)-W/W(v) mice that were sensitized to ovalbumin (OVA) without adjuvant, then challenged repetitively with antigen intranasally, exhibited much weaker responses ..
  71. ncbi Evaluation of the adjuvant effect of silver nanoparticles both in vitro and in vivo
    Yingying Xu
    Beijing National Laboratory for Molecular Sciences, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
    Toxicol Lett 219:42-8. 2013
    ..The in vivo adjuvant effect of AgNPs was evaluated with model antigen ovalbumin (OVA) and bovine serum albumin (BSA) in mice by intraperitoneal and subcutaneous immunization...
  72. pmc Allergen-induced airway remodeling is impaired in galectin-3-deficient mice
    Xiao Na Ge
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    J Immunol 185:1205-14. 2010
    ....
  73. pmc Mast cells are required for experimental oral allergen-induced diarrhea
    Eric B Brandt
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    J Clin Invest 112:1666-77. 2003
    ..These results demonstrate that oral allergen-induced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, IgE, serotonin, and PAF dependent...
  74. ncbi Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma
    Seung Hyung Kim
    Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon, Republic of Korea
    Eur J Pharmacol 701:131-43. 2013
    ..In this study, BALB/c mice were systemically sensitized to ovalbumin followed by intratracheal, intraperitoneal, and aerosol allergen challenges...
  75. ncbi Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma
    Tomomi Ichikawa
    First Department of Internal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Respirology 18:332-9. 2013
    ..However, the precise function of Sirtuin 1 (Sirt1), a class III histone deacetylase, and the effect of the Sirt1 activator SRT1720 on allergic inflammation have not been fully elucidated...
  76. pmc An extract of Crataegus pinnatifida fruit attenuates airway inflammation by modulation of matrix metalloproteinase-9 in ovalbumin induced asthma
    In Sik Shin
    Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea
    PLoS ONE 7:e45734. 2012
    ..effects of Crataegus pinnatifida ethanolic extracts (CPEE) on Th2-type cytokines, eosinophil infiltration, expression of matrix metalloproteinase (MMP)-9, and other factors, using an ovalbumin (OVA)-induced murine asthma model.
  77. pmc Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses
    Silvia B Boscardin
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:599-606. 2006
    ..delivered to DCs in lymphoid organs induce T cell help for antibody responses, we targeted a carrier protein, ovalbumin (OVA), to DCs in the presence of a maturation stimulus and assayed for antibodies to a hapten, (4-hydroxy-3-..
  78. ncbi Enhanced dendritic cell-induced immune responses mediated by the novel C-type lectin receptor mDCAR1
    Stefan A Kaden
    Miltenyi Biotec, Bergisch Gladbach, Germany
    J Immunol 183:5069-78. 2009
    ..These data indicate that mDCAR1 is a functional receptor on cells of the immune system and provides further insights into the regulation of immune responses by CLRs...
  79. ncbi Polyphenol-enriched apple extract attenuates food allergy in mice
    A W Zuercher
    Allergy Group, Department of Nutrition and Health, Nestle Research Center, Lausanne, Switzerland
    Clin Exp Allergy 40:942-50. 2010
    ..The immune system may be modulated with nutrition to prevent the development or to treat the symptoms of allergy. Among other foods, consumption of apples has been linked to reduced incidence of atopic dermatitis and respiratory allergy...
  80. ncbi Dual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccination
    Bram Slütter
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, Einsteinweg 55, 2333 CC Leiden, The Netherlands
    J Control Release 148:117-21. 2010
    ..agent was replaced by unmethylated CpG DNA, a TLR-9 ligand and a potent inducer of Th1 responses, to prepare ovalbumin (OVA) loaded TMC nanoparticles (TMC/CpG/OVA)...
  81. ncbi CD11c provides an effective immunotarget for the generation of both CD4 and CD8 T cell responses
    Fernanda V V Castro
    Tenovus Research Laboratory, Cancer Sciences Division, Southampton University School of Medicine, Southampton, UK
    Eur J Immunol 38:2263-73. 2008
    ..These results suggest that targeting antigen via CD11c offers a previously unappreciated strategy for vaccine development which, unlike most targets, delivers robust responses of both CD4 and CD8 T cells...
  82. ncbi Apigenin protects ovalbumin-induced asthma through the regulation of GATA-3 gene
    Jun Rim Choi
    Department of Microbiology and Immunology, Pusan National University School of Medicine, Busan 602 739, South Korea
    Int Immunopharmacol 9:918-24. 2009
    ..Thus we elucidated to anti-allergic effect of apigenin in ovalbumin (OVA)-induced asthma model mice. The OVA-induced mice showed allergic airway reactions...
  83. ncbi An ISCOM vaccine combined with a TLR9 agonist breaks immune evasion mediated by regulatory T cells in an orthotopic model of pancreatic carcinoma
    Collin Jacobs
    Department of Internal Medicine, University Hospitals, University of Munich, Munich, Germany
    Int J Cancer 128:897-907. 2011
    ..Combining ISCOM vaccines with TLR agonists is a promising strategy for breaking tumor immune evasion and deserves further evaluation for the treatment of pancreatic carcinoma...
  84. pmc Carbohydrate-mediated targeting of antigen to dendritic cells leads to enhanced presentation of antigen to T cells
    Eddie W Adams
    Center for Immunology and Inflammatory Diseases and Division of Rheumatology, Allergy and Immununology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Chembiochem 9:294-303. 2008
    ..A series of synthetic carbohydrates was chemically-coupled to a model antigen, ovalbumin (OVA), and each conjugate was evaluated for its ability to increase the efficiency of antigen presentation by ..
  85. ncbi Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma
    Alexandre P Rogerio
    Universidade Federal de Santa Catarina, Campus Universitario Trindade, Centro de Ciencias Biologicas, Florianopolis, SC, 88049 900, Brazil
    Eur J Pharmacol 580:262-70. 2008
    ..pacari extract and ellagic acid on allergic lung inflammation using a murine model of ovalbumin-induced asthma. In bronchoalveolar lavage fluid, preventive (22-day) treatment with L...
  86. ncbi ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells
    Peter Duewell
    Medizinische Klinik Innenstadt, Ludwig Maximilians Universitat, 80336 Munich, Germany
    J Immunol 187:55-63. 2011
    ..Thus, ISCOM vaccines combine potent immune activation with Ag delivery to CD8α(+) DCs in vivo for efficient induction of CTL responses...
  87. pmc Development of allergic airway disease in mice following antibiotic therapy and fungal microbiota increase: role of host genetics, antigen, and interleukin-13
    Mairi C Noverr
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    Infect Immun 73:30-8. 2005
    ..To investigate the role of antigen, we subjected mice with disrupted microbiota to intranasal challenge with ovalbumin (OVA)...
  88. ncbi The neonatal FcR-mediated presentation of immune-complexed antigen is associated with endosomal and phagosomal pH and antigen stability in macrophages and dendritic cells
    Xindong Liu
    Laboratory of Immunology, Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    J Immunol 186:4674-86. 2011
    ..Thus, our findings reveal that FcRn expression has a different effect on Ag processing and presentation of ICs to CD4(+) T cells in the endosomal versus phagosomal compartments of Ms versus DCs...
  89. ncbi Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model
    Seung Hyung Kim
    Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon, Republic of Korea
    J Pharm Pharmacol 61:353-9. 2009
    ....
  90. ncbi Modification of acute and late-phase allergic responses to ovalbumin with lipopolysaccharide
    Mark K Tulic
    Division of Clinical Sciences, TVW Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, W A, Australia
    Int Arch Allergy Immunol 129:119-28. 2002
    We have previously shown that lipopolysaccharide (LPS) exposure in sensitised animals 18 h after ovalbumin (OVA) challenge inhibits OVA-induced airway hyper-responsiveness (AHR)...
  91. pmc Blocking the leukotriene B4 receptor 1 inhibits late-phase airway responses in established disease
    Koichi Waseda
    Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Am J Respir Cell Mol Biol 45:851-7. 2011
    ..Female BALB/c mice were sensitized (Days 1 and 14) and challenged (primary, Days 28-30) with ovalbumin. On Day 72, mice were challenged (secondary) with a single OVA aerosol, and the early and late phases of AHR and ..
  92. pmc Early oral ovalbumin exposure during maternal milk feeding prevents spontaneous allergic sensitization in allergy-prone rat pups
    Adaweyah El-Merhibi
    Women s and Children s Health Research Institute, North Adelaide, SA, Australia
    Clin Dev Immunol 2012:396232. 2012
    ..This study investigated immune response development after early oral egg antigen (Ovalbumin; OVA) exposure in a rat pup model...
  93. ncbi Role of local pulmonary IFN-gamma expression in murine allergic airway inflammation
    Markus Koch
    Department of Immunology, Max Planck Institute for Infection Biology, Campus Charite Mitte, Schumannstrasse 21 22, 10117 Berlin, Germany
    Am J Respir Cell Mol Biol 35:211-9. 2006
    ..In contrast, airway hyperresponsiveness and anti-ovalbumin-IgE serum levels were reduced by local IFN-gamma expression...
  94. pmc Ginsenoside Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice
    Jianhua Sun
    Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang 310029, China
    Clin Vaccine Immunol 15:303-7. 2008
    The combined adjuvant effect of ginsenoside Rg1 and aluminum hydroxide (alum) on immune responses to ovalbumin (OVA) in mice was investigated. BALB/c mice were subcutaneously (s.c...
  95. ncbi IFATS collection: Immunomodulatory effects of adipose tissue-derived stem cells in an allergic rhinitis mouse model
    Kyu Sup Cho
    Department of Otorhinolaryngology, Medical Research Institute, Pusan National University School of Medicine, Busan, Korea
    Stem Cells 27:259-65. 2009
    ..The immunomodulatory effects of ASCs were evaluated by nasal symptoms, histology, serum ovalbumin (OVA)-specific antibody, and the cytokine profile of the spleen...
  96. ncbi Skin-derived dendritic cells can mediate deletional tolerance of class I-restricted self-reactive T cells
    Jason Waithman
    Department of Microbiology and Immunology, University of Melbourne, Parkville, Australia
    J Immunol 179:4535-41. 2007
    ..Thus, self-Ag can be carried to the draining lymph nodes by skin-derived DCs and there presented by these same cells for tolerization of the circulating T cell pool...
  97. ncbi 2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model
    S Huerta-Yepez
    Unidad de Investigación en Enfermedades Oncológicas, Hospital Infantil de Mexico, Federico Gomez, Mexico City, Mexico
    Clin Immunol 129:313-24. 2008
    ..Mice were sensitized with ovalbumin (OVA) that was administered intraperitoneally at days 0-5 and challenged intratracheally (IT) with OVA on days ..
  98. ncbi Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model
    Mee Young Lee
    Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, P O Box 115, Yusung, Daejeon 305 600, Korea
    Immunobiology 212:647-54. 2007
    ..of kefir, we used a mouse asthma model, in which airway inflammation and airway remodeling was produced by ovalbumin sensitization and challenge...
  99. pmc IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis
    Nir Grabie
    Immunology Research Division, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 111:671-80. 2003
    ..A transgenic mouse line was derived that expresses cardiac myocyte restricted membrane-bound ovalbumin (CMy-mOva). The endogenous adaptive immune system of CMy-mOva mice displays tolerance to ovalbumin...
  100. ncbi Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse
    Hiroki Nakahara
    Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu City, Japan
    Eur J Immunol 36:3334-45. 2006
    ..Bronchial asthma was induced by sensitization and challenge with ovalbumin. Littermates treated with saline were used as controls...
  101. ncbi House dust extracts have both TH2 adjuvant and tolerogenic activities
    Nicholas Ng
    Department of Medicine, University of California, San Diego, La Jolla 92093 0663, USA
    J Allergy Clin Immunol 117:1074-81. 2006
    ....

Research Grants70

  1. Nanopolymersomes for Transcutaneous Co-Delivery of Vaccine Antigens and Adjuvants
    PAUL CAMILLE TUMEH; Fiscal Year: 2013
    ..aims: AIM 1: Construct a biodegradable NPS-based delivery system that integrates/encapsulates the model antigen ovalbumin (OVA) and the adjuvant Toll-Like-Receptor-7 (TLR7)-agonist imiquimod (IMQ), generating OVA/IMQ-NPSs...
  2. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..Therapeutic administration of R-901 has been shown in a murine model of pulmonary inflammation (induced by ovalbumin sensitization and re-challenge) to reduce histologic injury, diminish leukocytic infiltration, attenuate tissue ..
  3. Neurotrophins in the Lung
    Y S Prakash; Fiscal Year: 2012
    ..In this proposal, we will use human ASM and the ovalbumin (OVA) mouse model to examine the relative role of the BDNF receptors (high affinity TrkB vs...
  4. A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary Dysplasia
    Prakash Jagtap; Fiscal Year: 2013
    ..In a murine ovalbumin model of pulmonary inflammation model, R-901 reduced histologic injury, diminished neutrophil infiltration, ..
  5. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..Selected compounds with potent IC50s will be tested in vivo in an adoptive transfer model using ovalbumin specific Th17 or Th1 cells IV as previously described...
  6. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..Therapeutic administration of R-901 has been shown in a murine model of pulmonary inflammation (induced by ovalbumin sensitization and re-challenge) to reduce histologic injury, diminish neutrophil (PMN) infiltration, attenuate ..
  7. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..Recently, we reported that experimental asthma induced by ovalbumin (OVA) sensitization of SCD mice increases pulmonary inflammation and collagen deposition in SCD mice to a much ..
  8. Genetic and Pharmacologic Evaluation of the Role of HIF-1a in asthma
    LAURA ELISE CROTTY ALEXANDER; Fiscal Year: 2013
    ..We will utilize an ovalbumin (OVA) model of allergic inflammatory airways disease in mice...
  9. ROLE OF MUC1 IN THE GENESIS OF ALLERGIC ASTHMA
    Kwang Chul Kim; Fiscal Year: 2010
    ..mice fail to exhibit pulmonary eosinophilia and goblet cell hyperplasia as seen in wild type littermates in an ovalbumin (OVA)-induced asthma model...
  10. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2013
    ..Peptides used in this proposal are from a model antigen (ovalbumin) and common melanoma antigens (gp100 and Trp-2)...
  11. Effect of Maspin on Corneal Heme-and lymph- angiogenesis
    Sally S Twining; Fiscal Year: 2013
    ..of maspin required for its anti-angiogenic properties will utilize chimeric proteins constructed from maspin and ovalbumin, phosphorylation mimics, phosphorylation null forms and maspin peptides...
  12. HIFU-enhanced tumor vaccines
    Chandan Guha; Fiscal Year: 2012
    ..Tumor cells expressing model tumor antigens, such as, ovalbumin (OVA) and carcinoembryonic antigen (CEA) will be used in these studies...
  13. The human gut microbiome, malnutrition and vaccine responses
    ANDREW LEON KAU; Fiscal Year: 2013
    ..I will follow their responses to mucosal vaccination with cholera toxin and ovalbumin (a model mucosal adjuvant/antigen) using antigen-specific ELISA...
  14. Role of T Cell Mediated Immunity In Emotion And Stress Responsiveness
    Leonardo H Tonelli; Fiscal Year: 2012
    ..10 transgenic mice. These mice express the transgene for the T-cell antigen receptor that is specific for ovalbumin and therefore these animals do contain OVA specific T-cells...
  15. CHEMOKINE RECEPTOR DYNAMICS IN GRANULOMA FORMATION
    Stephen W Chensue; Fiscal Year: 2013
    ..Methodologies will include the use of CCR4 targeted knockout mice, recombinant ovalbumin-producing M. bovis BCG-strain (BCG-OVA), adoptive D10...
  16. Role of Surfactant in Innate and Adaptive Immunity
    Jo Rae Wright; Fiscal Year: 2010
    ..isolated cells and in vivo with collectin null mice using two models of lung inflammation, the LPS model and the ovalbumin model of allergic inflammation...
  17. Unique immune regulation by alternatively spliced interleukin-4
    Sergei P Atamas; Fiscal Year: 2013
    ..In Specific Aim 2, effects of IL-442 gene delivery in vivo will be investigated in normal mice as well as in an ovalbumin-sensitized mouse model of asthma...
  18. Regulation of NF-kappaB in Lung Epithelium by ROS/RNS
    Yvonne M W Janssen-Heininger; Fiscal Year: 2013
    ..accelerated resolution of inflammation and airways hyperresponsiveness (AHR) in response to the antigen, ovalbumin. Conversely, inducible overexpression of Grx1 in bronchiolar epithelium dramatically increases inflammation in ..
  19. Epithelial JNK-TGFb1 Signaling Axis in Airway Remodeling
    Yvonne M W Janssen-Heininger; Fiscal Year: 2013
    ..Specifically, we have demonstrated that: 1) JNK is predominantly activated in airway epithelium from ovalbumin-sensitized and challenged mice;2) mice lacking JNK1 (JNK1-/-) fail to induce mesenchymal genes or develop ..
  20. Rho Kinase and Airway Hyperresponsiveness
    Stephanie A Shore; Fiscal Year: 2013
    ..Preliminary data indicate ROCK activation in lungs of ovalbumin (OVA) sensitized and challenged mice and show a marked reduction in OVA-induced AHR in ROCK2 vs wildtype (WT) ..
  21. Biomimetic Microsystem for High Throughput Evaluation of Engineered Nanomaterials
    Robert M Worden; Fiscal Year: 2010
    ..ability to promote airway disease by (1) increasing the murine immune system's response to the antigen ovalbumin, (2) increasing T cell activation by dendritic cells in response to ovalbumin, and (3) modifying the ELM's ..
  22. Mechanism of CTIP2 action in mouse epidermal homeostasis and barrier formation,
    ARUP K INDRA; Fiscal Year: 2012
    ..Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2 (CTIP2, also known as Bcl11b) is a ..
  23. Enhancing TB vaccine with gene silencing
    Jinhee Lee; Fiscal Year: 2013
    ..include DCs transfected with targeted siRNA or control siRNA and then tested for their ability to activate ovalbumin (OVA)-specific OT-II transgenic T cells in vitro and to sensitize animals with a Mycobacterium tuberculosis ..
  24. Myeloid cell interactions with T cells in atherosclerosis
    Klaus F Ley; Fiscal Year: 2013
    ..T cells derived from OTII transgenic mice express a monoclonal TCR that recognizes an ovalbumin peptide...
  25. Immunological Mechanisms in Systemic Autoimmune Disease
    Ann Marshak-Rothstein; Fiscal Year: 2012
    ..driven by either an invariant chain promoter or a vascular endothelial promoter and (2) a membrane-associated ovalbumin fusion protein whose expression is regulated by a tetracycline transactivator...
  26. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2012
    ..Animals were treated with approximately 13 different chemical agents (ovalbumin, , ozone, hyperoxia, 2,3-butanedione, acetoin, 2,3-pentanedione, benzene, indium phosphide, indium-tin-oxide, ..
  27. The Role of Caveolins in Lung Inflammation
    CHRISTINA MARIA PABELICK; Fiscal Year: 2013
    ..Finally in Aim 4, in vitro data will be integrated at the in vivo level using an ovalbumin (OVA) model of airway hyperresponsiveness in wildtype (WT) and caveolin-1 knockout (KO) mice...
  28. POLLEN GRAINS AS TROJAN HORSES FOR ORAL VACCINATION
    Harvinder Singh Gill; Fiscal Year: 2012
    ..We have tested the feasibility of our seemingly peculiar idea by feeding mice with pollen grains filled with ovalbumin as a model antigen...
  29. ASSEMBLY OF MHC CLASS I MOLECULES IN VITRO AND IN VIVO
    Hidde L Ploegh; Fiscal Year: 2012
    ..newly developed animal models, including a knock-in mouse model in which all B cells are poised to produce anti-ovalbumin antibodies by VDJ and VJ replacement in the Ig heavy chain and light chain loci, respectively...
  30. Lymphotoxin: Regulation and Biologic Function
    NANCY RUDDLE; Fiscal Year: 2009
    ..Lymphangiogenesis occurs in the skin after immunization with ovalbumin and complete Freund[unreadable]s adjuvant. This is enhanced in LTβ-/- mice...
  31. The Role of Mfge8 and Apoptotic Cell Clearance in Regulating Asthma Severity
    Kamran Atabai; Fiscal Year: 2010
    ..Our experimental approach involves evaluating the response of mice deficient in Mfge8 to an ovalbumin induced model of experimental asthma...
  32. Eosinophil Peroxidase in Allergic Inflammation
    Arne Slungaard; Fiscal Year: 2012
    ..all ameliorate the severe asthmatic phenotype which develops in these animals both spontaneously and after ovalbumin (OVA) sentitization and challenge...
  33. The role of lymphatic contraction in inflammation and cancer metastasis
    Shan Liao; Fiscal Year: 2013
    ..immune response is impaired during the period of lymphatic malfunction by measuring the immune response to ovalbumin (OVA) and a self-antigen (myelin oligodendrocyte glycoprotein peptide 35-55)...
  34. The developing intestinal immune system in Yersinia enterocolitica infection
    REBECCA D ADKINS; Fiscal Year: 2010
    ..An ovalbumin - expressing ?YopP strain will be created and ovalbumin-specific antibody and Th responses will be monitored, as ..
  35. Photo-inactivation of Leishmania for safe and effective delivery of surrogate vac
    Kwang Poo Chang; Fiscal Year: 2013
    ..e. ovalbumin (OVA) to APC, which presented this antigen effectively to activate OVA-specific T cells in vitro and in vivo...
  36. Initiation and Regulation of Chronic Autoimmune Prostate Inflammation
    Timothy L Ratliff; Fiscal Year: 2013
    ..We developed a novel transgenic mouse model expressing membrane bound ovalbumin exclusively on prostate epithelial cells to investigate prostate inflammatory processes and its regulation...
  37. Mucosal Adjuvants Targeting Dendritic Cells
    John G Nedrud; Fiscal Year: 2010
    ..We will evaluate this novel immunogen in mice employing both the model antigens Ovalbumin and ovalbumin peptides and two different classes of pathogens: a respiratory virus, Sendai virus and the gastric ..
  38. Molecular Mechanisms of IL-4 and IL-13 Signaling
    Achsah D Keegan; Fiscal Year: 2010
    ..on bone-marrow derived, non-lymphoid cells greatly enhances the eosinophilic inflammation in the lungs in an ovalbumin induced model of allergic inflammation...
  39. IL-4 Signal Transduction
    JOHN D COLGAN; Fiscal Year: 2013
    ..Moreover, NFIL3 KO mice sensitized and challenged with ovalbumin showed reduced airway hyper-responsiveness when compared to wild type mice...
  40. REGULATION OF NEONATAL IMMUNITY
    Habib Zaghouani; Fiscal Year: 2010
    ..Preliminary results indicate that one-day old Balb/c mice recipient of one-day-old ovalbumin (OVA)-specific TCR Tg DO11...
  41. Transgenerational Susceptibility to Asthma from Air Pollution Exposure
    Lester Kobzik; Fiscal Year: 2013
    ..cytokines, histology) and airway hyperresponsiveness (AHR) after an intentionally sub-optimal allergen (ovalbumin) sensitization and aerosol challenge protocol that has minimal effects in normal pups...
  42. Targeting CaM Kinase II and Oxidative Damage in Allergic Asthma
    Howard Schulman; Fiscal Year: 2011
    ..Optimized lead inhibitors will then be tested for efficacy in the ovalbumin mouse model of allergic asthma, monitoring its efficacy in AHR, goblet cell metaplasia, and mucous secretion...
  43. Induction of Tolerance to Factor VIII in Hemophilia
    DAVID WILLIAM SCOTT; Fiscal Year: 2012
    ..10 mice to follow the kinetics of induction of T-regs during gene therapy for fVIII and ovalbumin, respectively...
  44. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2011
    ..aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke, diacetyl, 2,3-pentanedione, benzene...
  45. Role of Langerhans Cells in the Cutaneous Immune System
    Daniel H Kaplan; Fiscal Year: 2013
    ..by combining an existing model of cutaneous Candidiasis with Candida albicans that we will engineer to express ovalbumin. We will be able to use this model to examine whether LC regulate or promote immune responses to yeast and how ..
  46. Immunomodulatory effects of intestinal helminthes on mucosal immunity
    Hai Ning Shi; Fiscal Year: 2013
    ..helminth infection also enhances intestinal inflammation in SCID mice that are adoptively transferred with ovalbumin (OVA) specific T cells and infected orally with OVA expressing E. coli...
  47. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2010
    ..aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke, diacetyl, 2,3-pentanedione, benzene...
  48. Mechanisms of Health Effects of Exercise in Children
    Dan M Cooper; Fiscal Year: 2013
    ..Consequently, we designed Project III to experimentally mimic asthma (ovalbumin sensitization) and obesity (overnutrition) using murine models at developmental stages roughly equivalent to ..
  49. Understanding Protective Immunoregulatory Mechanisms in the Infant Lung
    Prabir Ray; Fiscal Year: 2013
    ..of mTGF-[unreadable] in airway tolerance, it was recently shown that mothers tolerized to the antigen (Ag) ovalbumin (OVA) can transfer OVA and TGF-[unreadable] to their newborns via breast milk...
  50. Viral Infection and Impairment of Immune Tolerance
    Prabir Ray; Fiscal Year: 2012
    ..of mTGF-[unreadable] in airway tolerance, it was recently shown that mothers tolerized to the antigen (Ag) ovalbumin (OVA) can transfer OVA and TGF-[unreadable] to their newborns via breast milk showing a close correspondence ..
  51. Listeria-based vaccines engineered to modulate the innate immune system
    Daniel A Portnoy; Fiscal Year: 2011
    ..Strains engineered to express ovalbumin and four separate vaccinia CD8+ T-cell epitopes will be used to gauge the strength and duration of CD8 T-cells ..
  52. Functional Role of the Tetraspanin CD82/Kai1 in Innate and Adaptive Immunity
    Jatin M Vyas; Fiscal Year: 2013
    ..CD63 5) Biochemical evidence indicates that class II MHC and CD82 are associated 6) CD82-/- DCs loaded with ovalbumin failed to stimulate antigen-specific T cells as well as their wild-type counterparts...
  53. Secretory Phospholipase A2s in Airway Pathophysiology
    Teal S Hallstrand; Fiscal Year: 2013
    ..Murine models indicate that sPLA2-X is necessary for the development of ovalbumin-induced airway inflammation and airway hyperresponsiveness (AHR)...
  54. Role of Regulatory CD8 T Cells in Murine Asthma
    Roger S Thrall; Fiscal Year: 2013
    ..We have established a unique biphasic model of ovalbumin (OVA)-induced AAD, which with chronic OVA exposure results in resolution of AAD and the development of local ..
  55. Properties of Mouse of Dendritic Cells and Macrophages
    Svetlana Mojsov; Fiscal Year: 2013
    ..and adaptive immunity in intact animals;3) to develop strategies that gradually change current emphasis from ovalbumin to clinically relevant antigens, from TCR transgenic T cells to the polyclonal repertoire, and from mice to ..
  56. Mechanisms of Immune Modulation Mediated by Yeast-derived Particulate Beta-Glucan
    Jun Yan; Fiscal Year: 2012
    ..Lewis lung carcinoma transfected with surrogate antigen ovalbumin and tumor-associated antigen MUC1 will be used as the model systems to address those issues...
  57. Mucosal Therapy for Autoimmunity
    David W Pascual; Fiscal Year: 2013
    ..Our data show that oral or nasal application of the fusion protein, ovalbumin (OVA)-ps1, stimulates T and B cell unresponsiveness to OVA...
  58. M. TUBERCULOSIS INFECTION IN THE LUNG
    HENRY BOOM; Fiscal Year: 2010
    ..To use CD4+ MTB 85B- and ovalbumin-specific TCR transgenic mice to determine during M...
  59. Research on inhalation toxicology of environmental chemicals
    ROBERT O apos CONNER; Fiscal Year: 2009
    ..aspiration;ozone;lipopolysaccharide;hyperoxia;vanadium pentoxide;bleomycin, pulmonary function;ovalbumin, cigarette smoke...
  60. Immunomodulation of Vagal Innervation in the Respiratory Tract
    LETITIA ALEXIS WEIGAND; Fiscal Year: 2012
    ..bronchi, and lungs with the vagus nerve and vagal sensory ganglia will obtained from mice actively sensitized to ovalbumin (OVA), and extracellular recording of action potentials from afferent nerves in the lungs and airway wall will ..
  61. Neisserial Porins and Antigen Presenting Cells
    LEE MARK WETZLER; Fiscal Year: 2013
    ..We shall examine the ability of these adjuvants to induce immune responses to a test antigen, ovalbumin, which we have used previously as described in the Preliminary Data section...
  62. Novel Mechanisms of Smooth Muscle Beta2-receptor Regulation Relevant to Asthma
    Deepak A Deshpande; Fiscal Year: 2013
    ..binding domains will be crossed into the inducible IL-13 allergic mouse model with confirmatory studies in the ovalbumin (OVA) allergen induced mouse model...
  63. PEPTIDE BASED DELIVERY OF HIV IMMUNOGEN
    Lee Riley; Fiscal Year: 1999
    ..We have already shown that beta-galactosidase, green fluorescent protein, and ovalbumin expressed in fusion with Inv3 are able to abundantly associate with HeLa cells...
  64. CELLULAR AND MOLECULAR MECHANISMS FOR MUCOSAL IMMUNITY
    Kohtaro Fujihashi; Fiscal Year: 2005
    ..In addition, we discovered that Peyer's patches are a strict requirement for oral tolerance to proteins such as ovalbumin (OVA), but not to haptens such as trinitrophenyl sulfonic acid (TNBS)...
  65. HEAT SHOCK PROTEIN GP96 AND IMMUNITY
    Nicholas Cohen; Fiscal Year: 2003
    ..will be tested by examining the ability of Xenopus gp96 loaded with peptides from vesicular stomatitis virus and ovalbumin to prime murine CTL clones...
  66. Soluble TCR-IL15 Fusions as Targeted Therapeutics for Cancer
    Peter Rhode; Fiscal Year: 2009
    ..1 and a second (OT1scTCR) specific to the well-characterized ovalbumin peptide/Kb antigen...
  67. Immunological Basis of Egg Allergy
    Anna Nowak Wegrzyn; Fiscal Year: 2009
    ..IgE and IgG antibody avidity and epitope specificity to the two major egg white allergens (ovomucoid and ovalbumin) will be monitored on a yearly basis by peptide array in 90 patients with IgE-mediated egg allergy over 48 ..
  68. Airway Eosinophil Activation by Anticholinergic Therapy
    David Jacoby; Fiscal Year: 2009
    ..We have recently made the surprising observation that treating ovalbumin sensitized animals with the anticholinergic atropine at the time of antigen challenge markedly increases vagally ..
  69. Immunodeficiency and Autoimmunity
    ABUL ABBAS; Fiscal Year: 2009
    ..We have developed a transgenic mouse model in which CD4 helper T-cells specific for ovalbumin (Ova) become tolerant (functionally unresponsive) when they encounter a secreted form of Ova (sOva) produced as ..
  70. ASTHMA, ALLERGIC AND IMMUNOLOGIC DISEASES COOP RES CTR
    David Chaplin; Fiscal Year: 2000
    ..Aim 2 follows from the applicants initial data using the murine model of ovalbumin (OVA)-induced airway hypersensitivity which have demonstrated that both Th1 and Th2 cells enter the lung early ..