c reactive protein

Summary

Summary: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.

Top Publications

  1. doi Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
  2. pmc C-reactive protein: a critical update
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom
    J Clin Invest 111:1805-12. 2003
  3. ncbi Elevated C-reactive protein levels in overweight and obese adults
    M Visser
    Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    JAMA 282:2131-5. 1999
  4. ncbi Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    P M Ridker
    Center for Cardiovascular Disease Prevention and the Divisions of Preventive Medicine, Cardiovascular Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 101:1767-72. 2000
  5. ncbi Clinical application of C-reactive protein for cardiovascular disease detection and prevention
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 107:363-9. 2003
  6. ncbi Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)
    A Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78228 3900, USA
    Circulation 102:42-7. 2000
  7. ncbi Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility
    Cecilia Garlanda
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Annu Rev Immunol 23:337-66. 2005
  8. ncbi Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease
    Don D Sin
    Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
    Circulation 107:1514-9. 2003
  9. ncbi Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 344:1959-65. 2001
  10. ncbi Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction
    Roberto Latini
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Circulation 110:2349-54. 2004

Detail Information

Publications326 found, 100 shown here

  1. doi Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein
    Paul M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 359:2195-207. 2008
    ....
  2. pmc C-reactive protein: a critical update
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom
    J Clin Invest 111:1805-12. 2003
  3. ncbi Elevated C-reactive protein levels in overweight and obese adults
    M Visser
    Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    JAMA 282:2131-5. 1999
    ..Human adipose tissue expresses and releases the proinflammatory cytokine interleukin 6, potentially inducing low-grade systemic inflammation in persons with excess body fat...
  4. ncbi Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men
    P M Ridker
    Center for Cardiovascular Disease Prevention and the Divisions of Preventive Medicine, Cardiovascular Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 101:1767-72. 2000
    ..Interleukin-6 (IL-6) plays a central role in inflammation and tissue injury. However, epidemiological data evaluating the role of IL-6 in atherogenesis are sparse...
  5. ncbi Clinical application of C-reactive protein for cardiovascular disease detection and prevention
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 107:363-9. 2003
  6. ncbi Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS)
    A Festa
    Department of Medicine, University of Texas Health Science Center at San Antonio, 78228 3900, USA
    Circulation 102:42-7. 2000
    ..Recently, some components of the insulin resistance syndrome (IRS) have been related to inflammatory markers. We hypothesized that insulin insensitivity, as directly measured, may be associated with inflammation in nondiabetic subjects...
  7. ncbi Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility
    Cecilia Garlanda
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Annu Rev Immunol 23:337-66. 2005
    b>C reactive protein, the first innate immunity receptor identified, and serum amyloid P component are classic short pentraxins produced in the liver. Long pentraxins, including the prototype PTX3, are expressed in a variety of tissues...
  8. ncbi Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease
    Don D Sin
    Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
    Circulation 107:1514-9. 2003
    ..Chronic obstructive pulmonary disease (COPD) increases the risk of cardiovascular disease 2- to 3-fold. The factors responsible for this association remain largely unknown...
  9. ncbi Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    P M Ridker
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 344:1959-65. 2001
    ..We hypothesized that statins might prevent coronary events in persons with elevated C-reactive protein levels who did not have overt hyperlipidemia...
  10. ncbi Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction
    Roberto Latini
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Circulation 110:2349-54. 2004
    ..The aim of this study was to assess the prognostic value of PTX3 in MI compared with the best-known and clinically relevant biological markers...
  11. ncbi A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis
    Subodh Verma
    Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
    Circulation 106:913-9. 2002
    ....
  12. ncbi Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
    Hans K Meier-Ewert
    Department of Cardiology, Lahey Clinic Medical Center, Burlington, Boston, Massachusetts, USA
    J Am Coll Cardiol 43:678-83. 2004
    ..We sought to investigate the effects of sleep loss on high-sensitivity C-reactive protein (CRP) levels...
  13. ncbi Elevated levels of C-reactive protein and interleukin-6 in patients with obstructive sleep apnea syndrome are decreased by nasal continuous positive airway pressure
    Takuya Yokoe
    First Department of Internal Medicine, Showa University, Tokyo, Japan
    Circulation 107:1129-34. 2003
    ..In the present study, we examined serum levels of CRP and IL-6, IL-6 production by monocytes, and the effect of nasal continuous positive airway pressure (nCPAP) in patients with obstructive sleep apnea syndrome (OSAS)...
  14. ncbi Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease
    P M Ridker
    Brigham and Women s Hospital, 900 Commonwealth Ave E, Boston, MA 02215, USA
    JAMA 285:2481-5. 2001
    ..Several novel risk factors for atherosclerosis have recently been proposed, but few comparative data exist to guide clinical use of these emerging biomarkers...
  15. ncbi Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 352:29-38. 2005
    ..Intensive treatment produced greater reductions in both low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP), suggesting a relationship between these two biomarkers and disease progression...
  16. ncbi The impact of preoperative serum C-reactive protein on the prognosis of patients with hepatocellular carcinoma
    Koji Hashimoto
    Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan
    Cancer 103:1856-64. 2005
    ..The authors evaluated the significance of the preoperative serum C-reactive protein (CRP) level as a prognostic indicator in patients with hepatocellular carcinoma (HCC)...
  17. ncbi C-reactive Protein
    Steven Black
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 279:48487-90. 2004
    ..This review will largely focus on our current understanding of the structure of CRP, its ligands, the effector molecules with which it interacts, and its apparent functions...
  18. ncbi Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, CA 95817, USA
    Diabetes 55:774-9. 2006
    ..These results have a major implication on our understanding of the role of inflammation in vasculopathies in type 1 diabetes...
  19. ncbi Is obesity an inflammatory condition?
    U N Das
    EFA Sciences LLC, Norwood, Massachusets 02062, USA
    Nutrition 17:953-66. 2001
    ....
  20. ncbi Association between C-reactive protein and features of the metabolic syndrome: a population-based study
    M Frohlich
    Department of Internal Medicine II, University of Ulm Medical Center, Germany
    Diabetes Care 23:1835-9. 2000
    ..To assess the association of circulating levels of C-reactive protein, a sensitive systemic marker of inflammation, with different components of the metabolic syndrome...
  21. ncbi The role of C-reactive protein as a prognostic indicator in advanced cancer
    Fade Aziz Mahmoud
    Taussig Cancer Center, The Cleveland Clinic Foundation, M76, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Oncol Rep 4:250-5. 2002
    ..Measurement of CRP is simple, cheap, and routine and provides valuable information in palliative care...
  22. pmc Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence
    Mohit Trikha
    Centocor, Malvern, Pennsylvania 19355, USA
    Clin Cancer Res 9:4653-65. 2003
    ..The fact that anti-IL-6 mAb therapy decreased the incidence of cancer-related anorexia and cachexia may also be useful in the treatment of cancer patients...
  23. ncbi Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston 02215, USA
    N Engl J Med 347:1557-65. 2002
    ..Both C-reactive protein and low-density lipoprotein (LDL) cholesterol levels are elevated in persons at risk for cardiovascular events. However, population-based data directly comparing these two biologic markers are not available...
  24. doi Baseline C-reactive protein is associated with incident cancer and survival in patients with cancer
    Kristine H Allin
    Department of Clinical Biochemistry, Herlev Hospital, and the Copenhagen City Heart Study, Bispebjerg Hospital, Copenhagen University Hospital, Denmark
    J Clin Oncol 27:2217-24. 2009
    ..We tested the hypothesis that baseline plasma levels of C-reactive protein (CRP) are associated with risk of incident cancer in the general population and early death in patients with cancer...
  25. ncbi The metabolic syndrome, inflammation, and risk of cognitive decline
    Kristine Yaffe
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    JAMA 292:2237-42. 2004
    ..Despite an increasing awareness that cardiovascular risk factors increase risk of cognitive decline and dementia, there are few data on the metabolic syndrome and cognition...
  26. ncbi Obesity is a major determinant of the association of C-reactive protein levels and the metabolic syndrome in type 2 diabetes
    Steven E Kahn
    Department of Internal Medicine, Division of Metbolism, Endocrinology and Nurtrition, VA Puget Sound Health Care System, 151, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes 55:2357-64. 2006
    ..Further, for CRP and fibrinogen this relationship is determined by body adiposity and not by insulin sensitivity or glucose control...
  27. ncbi Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis
    Ville Pettila
    Department of Surgery, Division of Anesthesiology and Intensive Care Medicine, Helsinki University Hospital, P O Box 340, 00029 HUS, Helsinki, Finland
    Intensive Care Med 28:1220-5. 2002
    ....
  28. ncbi Inflammation as a cardiovascular risk factor
    James T Willerson
    University of Texas Health Science Center and Texas Heart Institute at Houston, 77225, USA
    Circulation 109:II2-10. 2004
    ..Although the magnitude of risk reduction associated with statin use appears to be largest for those with the highest serum levels of CRP, whether CRP reduction per se lowers cardiovascular risk is unknown...
  29. ncbi Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis
    Bernard Uzzan
    APHP Laboratoire de Pharmacologie Hormonologie, Hopital Avicenne, Bobigny, France
    Crit Care Med 34:1996-2003. 2006
    ..To draw and compare the summary receiver operating characteristics curves for procalcitonin and C-reactive protein from the literature...
  30. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
    ..We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances...
  31. doi An inflammation-based prognostic score and its role in the nutrition-based management of patients with cancer
    Donald C McMillan
    University Dept of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Proc Nutr Soc 67:257-62. 2008
    ..The role of GPS in clinical decision making will be discussed...
  32. ncbi Race and gender differences in C-reactive protein levels
    Amit Khera
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    J Am Coll Cardiol 46:464-9. 2005
    ..This study sought to determine whether there are race and gender differences in the distribution of C-reactive protein (CRP) levels...
  33. ncbi PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization
    Antonietta Salustri
    Department of Public Health and Cell Biology, University of Rome Tor Vergata, Rome 00133, Italy
    Development 131:1577-86. 2004
    ..Thus, PTX3 is a structural constituent of the cumulus oophorus extracellular matrix essential for female fertility...
  34. ncbi Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6
    Hye Soon Park
    Department of Family Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388 1 Pungnap dong, Songpa Gu, Seoul 138 736, South Korea
    Diabetes Res Clin Pract 69:29-35. 2005
    ..To investigate the relationship between serum concentrations of the cytokines C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6, and obesity and visceral adiposity...
  35. ncbi Systemic inflammatory response predicts survival following curative resection of colorectal cancer
    D C McMillan
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Surg 90:215-9. 2003
    ..The aim of this study was to examine the relationship between the inflammatory response and overall and cancer-specific survival in patients undergoing potentially curative resection for colorectal cancer...
  36. pmc A systematic review of the association between circulating concentrations of C reactive protein and cancer
    Katriina Heikkilä
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    J Epidemiol Community Health 61:824-33. 2007
    ..was to review and summarise the published evidence for an association between circulating concentrations of C reactive protein (CRP) and cancer through a systematic review. 90 discrete studies were identified...
  37. pmc Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster randomised trial
    Jochen W L Cals
    Department of General Practice, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, PO Box 616, 6200 MD Maastricht, Netherlands
    BMJ 338:b1374. 2009
    To assess the effect of general practitioner testing for C reactive protein (disease approach) and receiving training in enhanced communication skills (illness approach) on antibiotic prescribing for lower respiratory tract infection.
  38. ncbi The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study
    J I Barzilay
    Division of Endocrinology, Kaiser Permanente of Georgia, and the Division of Endocrinology, Emory University School of Medicine, Atlanta, Georgia 30084, USA
    Diabetes 50:2384-9. 2001
    ..Understanding the role of inflammation in the pathogenesis of glucose disorders in this age-group may lead to better classification and treatment of glucose disorders among them...
  39. pmc IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study
    Dilyara G Yanbaeva
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht NUTRIM, Maastricht University Medical Centre, Maastricht, The Netherlands
    BMC Med Genet 10:23. 2009
    ..The aim of this study was to examine the association between haplotypes of CRP, IL6 and FGB genes, systemic inflammation, COPD risk and COPD-related phenotypes (respiratory impairment, exercise capacity and body composition)...
  40. ncbi Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis
    Liliana Simon
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Clin Infect Dis 39:206-17. 2004
    ..On the basis of this analysis, the diagnostic accuracy of PCT markers was higher than that of CRP markers among patients hospitalized for suspected bacterial infections...
  41. ncbi Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
    Cecilia Garlanda
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Nature 420:182-6. 2002
    ..Thus, the long pentraxin Ptx3 is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents, in particular to the opportunistic fungal pathogen Aspergillus fumigatus...
  42. doi The utility of serum C-reactive protein in differentiating bacterial from nonbacterial pneumonia in children: a meta-analysis of 1230 children
    Robert G Flood
    Department of Pediatrics, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Pediatr Infect Dis J 27:95-9. 2008
    ..Although several studies have evaluated serum concentrations of C-reactive protein (CRP) as a predictor of bacterial pneumonia in this patient population, the utility of this test remains unclear...
  43. doi The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, Canada
    Am J Respir Crit Care Med 177:1207-14. 2008
    ..Small studies have suggested that inhaled corticosteroids can suppress systemic inflammation in chronic obstructive pulmonary disease (COPD)...
  44. ncbi Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component
    B Bottazzi
    From the Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    J Biol Chem 272:32817-23. 1997
    ....
  45. ncbi C-reactive protein: a valuable marker of sepsis
    Pedro Povoa
    Unidade de Cuidados Intensivos, Hospital Garcia de Orta, Avenida Prof Torrado da Silva, Pragal, 2800 525 Almada, Portugal
    Intensive Care Med 28:235-43. 2002
  46. ncbi Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component
    F Breviario
    Istituto Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Biol Chem 267:22190-7. 1992
    ..PTX3 may represent a novel marker of inflammatory reactions, particularly those involving the vessel wall...
  47. ncbi Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
    ..These data strongly support the hypothesis that a subclinical inflammatory reaction has a role in the pathogenesis of type 2 diabetes...
  48. ncbi C-reactive protein: risk marker or mediator in atherothrombosis?
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, 4635 Second Ave, Res 1 Bldg, Rm 3000, Sacramento, Calif 95817, USA
    Hypertension 44:6-11. 2004
    ..In conclusion, CRP is a risk marker for cardiovascular disease and, based on future studies, could emerge as a mediator in atherogenesis...
  49. pmc Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
    W Q Gan
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, British Columbia, Canada V6A 1Y6
    Thorax 59:574-80. 2004
    ..Systemic inflammation may be involved in the pathogenesis of these disorders. A study was undertaken to determine whether systemic inflammation is present in stable COPD...
  50. doi Immunoassay for human serum hepcidin
    Tomas Ganz
    Intrinsic LifeSciences LLC, La Jolla, CA, USA
    Blood 112:4292-7. 2008
    ..The new serum hepcidin enzyme-linked immunosorbent assay yields accurate and reproducible measurements that appropriately reflect physiologic, pathologic, and genetic influences, and is informative about the etiology of iron disorders...
  51. ncbi C-reactive protein and the risk of developing hypertension
    Howard D Sesso
    Department of Medicine, Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02215 1204, USA
    JAMA 290:2945-51. 2003
    ..Although it has been hypothesized that hypertension is in part an inflammatory disorder, clinical data linking inflammation with incident hypertension are scarce...
  52. doi Use of multiple biomarkers to improve the prediction of death from cardiovascular causes
    Bjorn Zethelius
    Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
    N Engl J Med 358:2107-16. 2008
    ..The incremental usefulness of adding multiple biomarkers from different disease pathways for predicting the risk of death from cardiovascular causes has not, to our knowledge, been evaluated among the elderly...
  53. pmc Inflammatory markers are associated with ventilatory limitation and muscle dysfunction in obstructive lung disease in well functioning elderly subjects
    S Yende
    CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, PA 15238, USA
    Thorax 61:10-6. 2006
    ..Inflammatory markers are increased in chronic obstructive pulmonary disease (COPD) and are hypothesised to play an important part in muscle dysfunction and exercise intolerance...
  54. ncbi C-reactive protein levels correlate with mortality and organ failure in critically ill patients
    Suzana M A Lobo
    Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
    Chest 123:2043-9. 2003
    ..This study assessed the association between early serum CRP concentrations and the development of organ failure and mortality in ICU patients...
  55. pmc Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction
    Gian Paolo Castelli
    Intensive Care, Anesthesiology and Pain Relief Unit, C Poma Hospital, Mantova, Italy
    Crit Care 8:R234-42. 2004
    ..We hypothesised that PCT and CRP concentrations are different in patients with infection or with no infection at a similar severity of organ dysfunction or of systemic inflammatory response...
  56. pmc Evaluation of an inflammation-based prognostic score in patients with inoperable gastro-oesophageal cancer
    A B C Crumley
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 94:637-41. 2006
    ..Moreover, the GPS may be used in combination with conventional staging techniques to improve the prediction of survival in patients with inoperable gastro-oesophageal cancer...
  57. ncbi Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian
    Jonathan Krakoff
    Diabetes and Arthritis Epidemiology Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85014, USA
    Diabetes Care 26:1745-51. 2003
    ....
  58. ncbi Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study
    Ramachandran S Vasan
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Circulation 107:1486-91. 2003
    ..It is unclear whether cytokine levels can predict the incidence of CHF in asymptomatic individuals...
  59. ncbi TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins
    G W Lee
    Department of Microbiology, New York University Medical Center, NY 10016
    J Immunol 150:1804-12. 1993
    ..Our data strongly suggest that TSG-14 is a novel member of the pentaxin family of acute phase proteins...
  60. ncbi Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study
    Thang S Han
    Addenbrooke s Hospital, Cambridge University Medical School, Cambridge, U K
    Diabetes Care 25:2016-21. 2002
    ..We evaluated CRP as a possible risk factor of the development of diabetes and metabolic syndrome in a 6-year study of 515 men and 729 women from the Mexico City Diabetes Study...
  61. ncbi C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice
    Antoni Paul
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 109:647-55. 2004
    ..Plasma C-reactive protein (CRP) concentration is a strong predictor of atherosclerosis. However, to date, there is no in vivo evidence that CRP is proatherogenic...
  62. ncbi Inflammatory proteins in plasma and the risk of dementia: the rotterdam study
    Marianne J Engelhart
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Neurol 61:668-72. 2004
    ..Increased levels of inflammatory proteins have been found in the brains and plasma samples of patients with dementia. Whether the levels of inflammatory proteins in plasma samples are elevated before clinical onset of dementia is unclear...
  63. ncbi Serum amyloid A as a predictor of coronary artery disease and cardiovascular outcome in women: the National Heart, Lung, and Blood Institute-Sponsored Women's Ischemia Syndrome Evaluation (WISE)
    B Delia Johnson
    Graduate School of Public Health, University of Pittsburgh, Parran 127, 130 DeSoto St, Pittsburgh, PA 15261, USA
    Circulation 109:726-32. 2004
    ..However, prior studies have yielded inconsistent results, and the independent predictive value of SAA for coronary artery disease (CAD) severity and cardiovascular events remains unclear...
  64. ncbi Procalcitonin behaves as a fast responding acute phase protein in vivo and in vitro
    M W Nijsten
    Department of Surgery, University Hospital Groningen, and the Groningen Institute for Drug Studies, The Netherlands
    Crit Care Med 28:458-61. 2000
    ..The source of production and its mechanism of induction are unknown. We investigated the inducibility of PCT both in vivo and in vitro and compared the behavior of PCT with those of SAA and CRP...
  65. doi Serum C-reactive protein as independent prognostic variable in patients with ovarian cancer
    Lukas A Hefler
    Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Clin Cancer Res 14:710-4. 2008
    ..To evaluate serum C-reactive protein (CRP) as prognostic variable in patients with epithelial ovarian cancer (EOC)...
  66. ncbi High-sensitivity C-reactive protein and coronary heart disease mortality in patients with type 2 diabetes: a 7-year follow-up study
    Minna Soinio
    Department of Medicine, Turku University Central Hospital, P O Box 52, FIN 20521 Turku, Finland
    Diabetes Care 29:329-33. 2006
    ..To investigate in a follow-up study whether high-sensitivity C-reactive protein (hs-CRP) predicts coronary heart disease (CHD) events in subjects with type 2 diabetes...
  67. ncbi Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes
    V V Alles
    Laboratory of Immunology, Istituto di Ricerche Farmacologiche, Mario Negri, Milano, Italy
    Blood 84:3483-93. 1994
    ..Thus, PTX3, unlike the classical pentraxins CRP and SAP, is expressed and released by cells of the monocyte-macrophage lineage exposed to inflammatory signals...
  68. ncbi Structure and function of the long pentraxin PTX3 glycosidic moiety: fine-tuning of the interaction with C1q and complement activation
    Antonio Inforzato
    Department of Biology, University Tor Vergata, Rome, Italy
    Biochemistry 45:11540-51. 2006
    ..In conclusion, our results provided evidence of an involvement of the PTX3 sugar moiety in C1q recognition and complement activation...
  69. doi C-reactive protein and coronary heart disease: predictive test or therapeutic target?
    Aroon D Hingorani
    Division of Population Sciences, Department of Epidemiology and Public Health, University College London, London, UK
    Clin Chem 55:239-55. 2009
    ..The research has encompassed observational and genetic epidemiology, basic science studies with cells and tissues, experiments with animal models and humans, and randomized trials (although not of specific CRP-lowering therapies as yet)...
  70. ncbi Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults
    Earl S Ford
    Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Epidemiology 13:561-8. 2002
    ..The purpose of this study was to examine the association between physical activity and C-reactive protein concentration in a national sample of the U.S. population...
  71. ncbi Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults
    Jerome L Abramson
    Department of Medicine Cardiology, Emory University School of Medicine, 1256 Briarcliff Rd NE, Suite 1 North, Atlanta, GA 30306, USA
    Arch Intern Med 162:1286-92. 2002
    ..Because coronary heart disease is increasingly seen as an inflammatory process, it might be reasonable to hypothesize that physical activity reduces risk of coronary heart disease by reducing or preventing inflammation...
  72. ncbi C-reactive protein and the risk of incident colorectal cancer
    Thomas P Erlinger
    Department of Medicine, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    JAMA 291:585-90. 2004
    ..Inflammation may play a role in the pathogenesis of colorectal cancer; however, epidemiological evidence supporting this hypothesis in average-risk persons is sparse...
  73. ncbi Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice
    Haim D Danenberg
    Harvard MIT Division of Health Sciences and Technology, Cambridge, Mass 02139, USA
    Circulation 108:512-5. 2003
    ..To determine whether CRP directly modulates vascular cell function in vivo, we subjected wild-type mice, which do not express CRP, and human CRP-transgenic (CRPtg) mice to 2 models of arterial injury...
  74. ncbi Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: association between C-reactive protein (CRP) gene polymorphisms and vascular events
    A J Szalai
    The University of Alabama, Birmingham, AL 35294 3408, USA
    Rheumatology (Oxford) 44:864-8. 2005
    ..To determine if a polymorphic GTn repeat in the intron of the C-reactive protein (CRP) gene associates with occurrence of vascular arterial events in systemic lupus erythematosus (SLE)...
  75. pmc CRP after 2004
    Alok Agrawal
    Department of Pharmacology, East Tennessee State University, P O Box 70577, Johnson City, TN 37614, USA
    Mol Immunol 42:927-30. 2005
    ..CRP is currently serving as an indicator of cardiovascular diseases, but to pinpoint the role of CRP in atherosclerosis, a drug that can lower cholesterol levels, but not the CRP levels, is needed for experimentation...
  76. ncbi Local release of C-reactive protein from vulnerable plaque or coronary arterial wall injured by stenting
    Teruo Inoue
    Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan
    J Am Coll Cardiol 46:239-45. 2005
    ..The purpose of this study was to assess local release of C-reactive protein (CRP) from atherosclerotic plaques or the vessel wall injured by stenting...
  77. ncbi Three dimensional structure of human C-reactive protein
    A K Shrive
    Department of Physics, Keele University, Keele, UK
    Nat Struct Biol 3:346-54. 1996
    ..The structure provides insights into the molecular mechanisms by which this highly conserved plasma protein, for which no polymorphism or deficiency state is known, may exert its biological role...
  78. ncbi Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study)
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Cardiol 92:522-8. 2003
    ..Thus, our findings suggest an important role for IL-6 and TNF-alpha in clinical as well as subclinical cardiovascular disease. In this study, CRP had a weaker association with cardiovascular disease than the cytokines...
  79. ncbi Biochemical and functional characterization of the interaction between pentraxin 3 and C1q
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 33:465-73. 2003
    ..These results indicate that PTX3 can both inhibit and activate the classical complement pathway by binding C1q, depending on the way it is presented. PTX3 may therefore be involved in the regulation of the innate immune response...
  80. ncbi Significance of preoperative elevation of serum C-reactive protein as an indicator of prognosis in esophageal carcinoma
    T Nozoe
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi Ward, 812 8582, Fukuoka, Japan
    Am J Surg 182:197-201. 2001
    ..The aim of this study was to establish the significance of preoperative elevation of serum CRP as an indicator of prognosis in patients with esophageal carcinoma...
  81. ncbi Relations of plasma high-sensitivity C-reactive protein to traditional cardiovascular risk factors
    Mayumi Saito
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
    Atherosclerosis 167:73-9. 2003
    ....
  82. ncbi Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability
    L M Biasucci
    Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy
    Circulation 99:855-60. 1999
    ..In a group of patients admitted for unstable angina, we investigated whether C-reactive protein (CRP) plasma levels remain elevated at discharge and whether persistent elevation is associated with recurrence of instability...
  83. pmc Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia
    Beat Muller
    Departments of Internal Medicine, University Hospital, Petersgraben 4, CH 4031, Basel, Switzerland
    BMC Infect Dis 7:10. 2007
    ..This study aims to evaluate the diagnostic and prognostic accuracy of clinical signs and symptoms and laboratory biomarkers for CAP...
  84. ncbi Production of the long pentraxin PTX3 in advanced atherosclerotic plaques
    Michael S Rolph
    Heart Research Institute, Camperdown, New South Wales, Australia
    Arterioscler Thromb Vasc Biol 22:e10-4. 2002
    ..Infrequent expression by smooth muscle cells was also observed. Our results suggest that PTX3 may contribute to the pathogenesis of atherosclerosis...
  85. pmc Comparison of an inflammation-based prognostic score (GPS) with performance status (ECOG) in patients receiving platinum-based chemotherapy for inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Br J Cancer 90:1704-6. 2004
    ..On multivariate analysis with ECOG, white cell count and the GPS entered as covariates, only the GPS was a significant independent predictor of survival (HR 1.88, 95% CI 1.25-2.84, P=0.002)...
  86. ncbi C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease
    John Danesh
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    N Engl J Med 350:1387-97. 2004
    ..We report data from a large study of C-reactive protein and other circulating inflammatory markers, as well as updated meta-analyses, to evaluate their relevance to the prediction of coronary heart disease...
  87. pmc Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer
    L M Forrest
    University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK
    Br J Cancer 89:1028-30. 2003
    ..001) was comparable in prognostic value to that based on stage and performance status (HR 1.48, 95% CI 1.12 - 1.95, P=0.006) in patients with inoperable non-small-cell lung cancer. The former is simple to measure and well standardised...
  88. ncbi Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study
    N S Rost
    National Heart, Lung, and Blood Institute's Framingham Study, Framingham, Massachusetts, USA
    Stroke 32:2575-9. 2001
    ..0365) and women (P=0.0084). CONCLUSIONS: Independent of other cardiovascular risk factors, elevated plasma CRP levels significantly predict the risk of future ischemic stroke and TIA in the elderly...
  89. ncbi Antihypertensive medications and C-reactive protein in the multi-ethnic study of atherosclerosis
    Walter Palmas
    Division of General Medicine, Department of Medicine, Mailman School of Public Health, Columbia University Medical Center, New York, New York
    Am J Hypertens 20:233-41. 2007
    ..The effects of different antihypertensive medication classes on C-reactive protein (CRP) levels are still not well characterized, and might be of relevance to treatment choices...
  90. ncbi Association between carotid atherosclerosis and markers of inflammation in rheumatoid arthritis patients and healthy subjects
    INMACULADA DEL RINCON
    University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Arthritis Rheum 48:1833-40. 2003
    ..To examine the relationship between markers of systemic inflammation and carotid atherosclerosis in patients with rheumatoid arthritis (RA) and healthy controls...
  91. ncbi C-reactive protein in ischemic stroke: an independent prognostic factor
    M Di Napoli
    Department of Neurology and Neurorehabilitation, Casa di Cura Villa Pini d Abruzzo, Chieti, Italy
    Stroke 32:917-24. 2001
    ..Therefore, we assessed the prognostic values of CRP in ischemic stroke. We also compared the relation of CRP at admission and discharge with 1-year outcome...
  92. pmc C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance
    Huijun Sun
    Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    Am J Pathol 167:1139-48. 2005
    ..These results suggest that there is a link between plasma CRP and the degree of atherosclerosis and that inhibition of plasma CRP may represent a therapeutic modality for the treatment of cardiovascular disease...
  93. ncbi Improvement in Castleman's disease by humanized anti-interleukin-6 receptor antibody therapy
    N Nishimoto
    Department of Medical Science I, School of Health and Sport Sciences, Osaka University, Suita City, Osaka, Japan
    Blood 95:56-61. 2000
    ..Blood. 2000;95:56-61)..
  94. pmc Neuronal pentraxins mediate synaptic refinement in the developing visual system
    Lisa Bjartmar
    Department of Neurosciences, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Neurosci 26:6269-81. 2006
    ..We speculate that NPs exert their effects through mechanisms that parallel the known role of short pentraxins outside the CNS...
  95. ncbi C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol
    Tsutomu Kazumi
    Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women s University, Health Science Center, Nishonomiya, Japan
    Metabolism 52:1113-6. 2003
    ..Although low-grade inflammation was associated with long QTc interval and low HDL-cholesterol, the mechanism underlying these associations is an important question to be addressed...
  96. ncbi Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis
    Indra Z Mustapha
    Department of Periodontology, Howard University, Washington, DC, USA
    J Periodontol 78:2289-302. 2007
    ..The purpose of this study was to review and analyze the association between PD with elevated systemic bacterial exposure and CVD...
  97. ncbi Inflammation in hypertension
    Carmine Savoia
    Clinical Research Institute of Montreal, University of Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 15:152-8. 2006
    ..In this review we summarize the recent evidence that highlights the involvement of low-grade inflammation in the development and pathophysiology of hypertension...
  98. ncbi Periodontal infections contribute to elevated systemic C-reactive protein level
    B Noack
    Department of Oral Biology, University at Buffalo, NY 14214, USA
    J Periodontol 72:1221-7. 2001
    ..The positive correlation between CRP and periodontal disease might be a possible underlying pathway in the association between periodontal disease and the observed higher risk for CVD in these patients...
  99. pmc Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections
    Kristian Kofoed
    Clinical Research Unit, Copenhagen University Hospital, Hvidovre, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    Crit Care 11:R38. 2007
    ..Combinations of markers, as opposed to single ones, may improve diagnosis and thereby survival. We therefore compared the diagnostic characteristics of novel and routinely used biomarkers of sepsis alone and in combination...
  100. ncbi C-reactive protein as a prognostic variable that reflects uncontrolled up-regulation of the IL-1-IL-6 network system in colorectal carcinoma
    Chikao Miki
    Second Department of Surgery, Mie University School of Medicine, Mie, Japan
    Dig Dis Sci 49:970-6. 2004
    ..The presence of an acute phase reactant reflects uncontrolled up-regulation of the local IL-1-IL-6 network system in the tumor, which may enhance the survival and proliferation of remnant cancer cells after tumor resection...
  101. ncbi High-grade C-reactive protein elevation correlates with accelerated atherogenesis in patients with rheumatoid arthritis
    Miguel A Gonzalez-Gay
    Divisions of Rheumatology and Cardiology, Hospital Xeral Calde, Lugo, Spain
    J Rheumatol 32:1219-23. 2005
    ..We examined the relationship between carotid IMT to C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), which are the most commonly assessed markers of inflammatory response in patients with RA...

Research Grants76

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Cardiovascular Responses to Sleep Apnea in Tetraplegia: A Pilot Study
    Jill M Wecht; Fiscal Year: 2010
    ....
  3. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..Findings from this study will suggest mechanisms to explain the prior observed associations between sleep duration and CVD risk factors. ..
  4. Effects of Evoked Resistance Training and Testosterone after Spinal Cord Injury
    Ashraf Gorgey; Fiscal Year: 2012
    ..The completion of the proposed experiment will allow the candidate to compete as an independent research investigator. ..
  5. METABOLIC SYNDROME AND PERIODONTITIS IN POSTMENOPAUSAL WOMEN
    Michael J LaMonte; Fiscal Year: 2013
    ..The existing resources for this secondary data analysis provide an unprecedented cost- efficient opportunity to build on established work and expand knowledge in this important area of public health. ..
  6. Alpha B crystallin as a novel therapeutic for SIRS and Sepsis
    Jonathan B Rothbard; Fiscal Year: 2011
    ..reduce in a dose dependent manner serological levels of IL-6, serum amyloid A, and C reactive protein in mice injected with LPS and (ii...
  7. Global regulatory interactions in bacterial pathogenesis
    BRIAN AKERLEY; Fiscal Year: 2009
    ..Immune signaling and effector pathways will be examined to define clearance mechanisms that H. influenzae is able to avoid by modulating its surface structures. ..
  8. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..Shorter telomeres have been linked to cancer risk. The project includes 438 postmenopausal, overweight/obese, sedentary women who have already completed the trial from which blood samples will be used. ..
  9. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..We also test if there is effect modification of APOE alleles on the association between ELCS &later-life biomarkers. ..
  10. Phenotyping Major Depression with Increased Inflammation
    Andrew H Miller; Fiscal Year: 2013
    ..abstract_text> ..
  11. METABOLISM, MICRONUTRIENTS, AND ANTIRETROVIRAL THERAPY OUTCOMES IN ZAMBIA
    DOUGLAS CORBETT HEIMBURGER; Fiscal Year: 2010
    ..Future intervention trials will address these metabolic and nutritional issues, to reduce early ART mortality and improve ART outcomes in resource-constrained settings. ..
  12. Addressing Psychosocial Disparities in Rural Hispanic Cancer Survivors
    Rachel M Ceballos; Fiscal Year: 2013
    ..abstract_text> ..
  13. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ....
  14. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ....
  15. Recombinant hepatic argininosuccinate synthase (rASS) for treatment of sepsis/end
    Stanislav I Svetlov; Fiscal Year: 2012
    ..Outcome will be a validated rASS formulation and protocol for treatment of endotoxemia/sepsis in mouse models. ..
  16. IGF-1, bone turnover and response to teriparatide in premenopausal women with IOP
    Adi Cohen; Fiscal Year: 2013
    ....
  17. Predicting persistent Organ Failure early in Acute Pancreatitis
    Georgios I Papachristou; Fiscal Year: 2013
    ..e. tumor necrosis factor-a inhibitors. ..
  18. Metabolic Syndrome and Breast Cancer: Effects of a Combined Exercise Intervention
    Christina Dieli-Conwright; Fiscal Year: 2013
    ..Survival rates for breast cancer are relatively high translating to a need for healthy living to diminish risk of other diseases such as diabetes and cardiovascular disease. ..
  19. Daily Experience in Adolescence and Biomarkers of Early Risk for Adult Health
    Andrew J Fuligni; Fiscal Year: 2013
    ..An understanding of these processes is necessary for the development of ethnically and culturally relevant prevention efforts. ..
  20. Inflammation and Sub-Clinical Renal Damage in Cocaine-Dependent African Americans
    ELIZABETH GROOMS NESMITH; Fiscal Year: 2010
    ....
  21. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ....
  22. Establishing the Precursors of Osteoporosis in Children
    Xiping Xu; Fiscal Year: 2010
    ....
  23. The Magnesium and Metabolic Syndrome Trial
    Stella Lucia Volpe; Fiscal Year: 2010
    ..If effective in improving insulin resistance in the metabolic syndrome, magnesium supplementation could have a great public health impact by delaying or preventing type 2 diabetes mellitus, and also in decreasing health care costs. ..
  24. CORONARY DISEASE MORBIDITY AND MORTALITY IN A POPULATION
    Veronique L Roger; Fiscal Year: 2012
    ..It will determine the importance of novel biomarkers to predict the risk of adverse events in clinical practice. ..
  25. Immunology, Inflammation, and Endometriosis
    STACEY ANN MISSMER; Fiscal Year: 2012
    ..We believe that quantifying these factors may improve our understanding of the etiology and consequences of endometriosis. ..
  26. A Trial of Zinc and Micronutrients in Tanzanian Children
    Christopher P Duggan; Fiscal Year: 2010
    ..As experts in the fields of nutrition, pediatrics, epidemiology and maternal and child health, our team is committed to further evaluating the possible role of micronutrients in improving child health. ..
  27. CRP, eNOS and Endothelial Dysfunction
    Philip W Shaul; Fiscal Year: 2010
    ..The proposed research program will determine how CRP and its cell surface receptors cause hypertension and insulin resistance. ..
  28. Fatty acid desaturase activity, fish oil and colorectal cancer chemoprevention
    Harvey J Murff; Fiscal Year: 2013
    ..We anticipate that fish oil will have anti-neoplastic effect and individuals with low FADS1 activity will have a greater response compared to individuals with high FADS1 activity. ..
  29. Effect of Diet on Inflammation in Sicke Cell Mice
    Jacqueline M Hibbert; Fiscal Year: 2010
    ..The use of this mouse model is important for investigating the time course of sickle cell induced tissue inflammation, and for seeking practical and effective dietary treatment to reduce the tissue injury. ..
  30. CARDIA Echocardiography Reading Center
    Joao A C Lima; Fiscal Year: 2012
    ..abstract_text> ..
  31. Coronary Artery Risk Development in Young Adults (CARDIA) Study - CC
    James Shikany; Fiscal Year: 2012
    ..abstract_text> ..
  32. CARDIA
    O Dale Williams; Fiscal Year: 2011
    ..abstract_text> ..
  33. CARDIA ECHO RC
    Joao Lima; Fiscal Year: 2010
    ..abstract_text> ..
  34. CARDIA ECHO RC CAN 9-8470189
    Joao Lima; Fiscal Year: 2009
    ..abstract_text> ..
  35. CARDIA
    Sharina D Person; Fiscal Year: 2010
    ..abstract_text> ..
  36. Biomarkers in HPA axis and inflammatory pathways for suicidal behavior in youth
    Nadine M Melhem; Fiscal Year: 2013
    ....
  37. CARDIA ECHO RC
    Joao A C Lima; Fiscal Year: 2011
    ..abstract_text> ..
  38. The Intestinal Microbiome in Pediatric NAFLD
    Nita H Salzman; Fiscal Year: 2010
    ..abstract_text> ..
  39. The Effects of C-Reactive Protein on Autoimmunity
    Terry W Du Clos; Fiscal Year: 2013
    ..Therefore, understanding the role this protein plays in the risk for SLE will aid in understanding the cause and treatment of this and other autoimmune diseases in Veterans. ..
  40. Risk for Dysfunctional Romantic Relationships for Adults
    Deborah M Capaldi; Fiscal Year: 2013
    ....
  41. Violence Exposure, Immune Function &HIV/AIDS Risks in African American Young Ad
    FROUGH SAADATMAND; Fiscal Year: 2013
    ..of immune system dysregulation includes heightened levels of antibodies to the Epstein Barr Virus (EBV) and C reactive protein (CRP)...
  42. Outcomes and Predictors in Mild Cognitive Impairment
    Mary Ganguli; Fiscal Year: 2012
    ..The Awardee will also continue to organize trainee workshops in neglected areas such as project management, principles of neuropsvcholoav for non-psvcholoaists. and scientific writing skills. ..
  43. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    ..The information obtained in this study will be relevant to millions of children in the US and abroad who are chronically exposed to lead, cadmium, and arsenic in the environment. ..
  44. Determinants of Telomere Length in Chronic SCI: A Pilot Study
    Eric Garshick; Fiscal Year: 2012
    ....
  45. Impact of exercise on ovarian cancer prognosis
    Melinda L Irwin; Fiscal Year: 2013
    ..abstract_text> ..
  46. Depression &CHD: Cellular-Molecular Mechanisms
    EDWARD CARLOS SUAREZ; Fiscal Year: 2013
    ....
  47. Chinese American Eye Study
    Rohit Varma; Fiscal Year: 2013
    ..These findings are also likely to be of increasing public health importance, as the societal burden of age-related eye disease will likely increase with the aging of this rapidly growing segment of the US population. ..
  48. Vitamin D deficiency and treatment in male veterans at risk for diabetes
    Elena Barengolts; Fiscal Year: 2013
    ....
  49. Long Term Implications of Preeclampsia: Role of Obesity vs sFlt-1 Overexpression
    Egle Bytautiene; Fiscal Year: 2009
    ..This model will also provide an experimental tool for investigating mechanisms of CVD and the well established gender differences in health and disease. ..
  50. Substituting Brown Rice for White Rice: Effect on Diabetes Risk Factors in India
    Mohan Viswanathan; Fiscal Year: 2012
    ..The ultimate goal of this research is to provide data for use in designing a global dietary intervention study aimed at reducing diabetes risk through simple, culturally appropriate, feasible and sustainable dietary changes. ..
  51. Perfluoroalkyl chemicals and the risk of developing clinical and subclinical CVD
    Anoop Shankar; Fiscal Year: 2012
    ..We will study the association between blood PFCs and cardiovascular disease. If we find an association, it indirectly suggests that reducing PFCs may have a role in preventing these diseases. ..
  52. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    KIANG J LIU; Fiscal Year: 2013
    ..abstract_text> ..
  53. Role of Oxidative Stress and Inflammation in HIV Cardiovascular Risk
    Cecilia M Shikuma; Fiscal Year: 2012
    ..End of Abstract) ..
  54. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    KIANG J LIU; Fiscal Year: 2012
    ..abstract_text> ..
  55. Epidemiologic Study of Sick Sinus Syndrome
    Alvaro Alonso; Fiscal Year: 2012
    ....
  56. Endothelial Dysfunction and the RV in the Multi-Ethnic Study of Atherosclerosis
    Steven M Kawut; Fiscal Year: 2010
    ..This study will focus on subclinical markers of pulmonary vascular disease and RV failure, which are increasingly important diseases impacting on older and minority Americans. ..
  57. CARDIA
    KIANG J LIU; Fiscal Year: 2009
    ..abstract_text> ..
  58. CARDIA
    KIANG J LIU; Fiscal Year: 2010
    ..abstract_text> ..
  59. CARDIA
    KIANG J LIU; Fiscal Year: 2011
    ..abstract_text> ..
  60. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    Stephen Sidney; Fiscal Year: 2013
    ..abstract_text> ..
  61. Coronary Artery Risk Development in Young Adults (CARDIA) - Field Center
    Cora E Lewis; Fiscal Year: 2012
    ..abstract_text> ..
  62. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    Pamela Schreiner; Fiscal Year: 2013
    ..abstract_text> ..
  63. Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center
    Stephen Sidney; Fiscal Year: 2012
    ..abstract_text> ..
  64. CARDIA
    Stephen Sidney; Fiscal Year: 2010
    ..abstract_text> ..
  65. Cardioprotective Effects of Dietary Flavonoids in the Framingham Offspring Cohort
    Paul Jacques; Fiscal Year: 2009
    ....
  66. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ....
  67. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2006
    ..These results can be used to formulate guidelines for identifying elderly subjects for statin treatment to prevent future CHD. ..
  68. Dose of Early Therapeutic Mobility: Does Type or Frequency of Activity Matter?
    Chris Winkelman; Fiscal Year: 2010
    ..This study is a preliminary step in the investigation of the optimal "dose" of ETM activity in mechanically ventilated patients and has the potential to improve recovery from critical illness. ..
  69. Exploring the effect of a low-fat diet and/or exercise on change in inflammatory
    Deborah Young; Fiscal Year: 2009
    ..These results can help determine what the optimal lifestyle changes are necessary to reduce inflammation, with the ultimate goal of reducing risk for coronary heart disease. ..
  70. CVD Mechanisms Associated with Phytoestrogens Use
    Donna Kritz Silverstein; Fiscal Year: 2003
    ..Given that women can expect to live one-third of their lives after menopause, it is important to know whether and how phytoestrogens may modify cardiovascular disease mechanisms. ..
  71. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ....
  72. NUTRITIONAL AND BIOCHEMICAL/GENETIC MARKERS OF CANCER
    Jing Ma; Fiscal Year: 2007
    ..Hence, the proposed project is highly cost-efficient. ..
  73. FcgRIIB links CRP signals with ITGAM functions: a G x G x G model of SLE.
    Alexander J Szalai; Fiscal Year: 2010
    ..If we can decipher the biological reasons for the genetic evidence of association of these 3 genes to lupus, then we can better predict who might develop the disease, and better treat those that already have the disease. ..
  74. CHEMISTRY AND BIOCHEMISTRY OF GLYCOCONJUGATES
    YUAN LEE; Fiscal Year: 2005
    ..These studies are significant from the evolutionary standpoint, since the occurrence of alpha-Gal in glycoproteins is rare in birds, and the responsible transferase seems to be different from that of mammals. ..
  75. EFFECTS OF TF/FVIIa INHIBITION IN CRP TRANSGENIC MICE
    Christopher Arnold; Fiscal Year: 2004
    ..Together, these models will help determine the in vivo anti-inflammatory and antithrombotic properties of BCX-3607, a potential agent for the treatment of acute coronary syndromes. ..
  76. CORRELATIVE STUDIES USING SPECIMENS FROM SWOG 9321
    John Shaughnessy; Fiscal Year: 2000
    ..Specific Aim 3: Evaluate whether chromosome 13 deletions correlate with clinical outcome (complete remission, event free survival, and overall survival). ..