peptide fragments

Summary

Summary: Partial proteins formed by partial hydrolysis of complete proteins.

Top Publications

  1. pmc Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy
    Xiping Wei
    Howard Hughes Medical Institute, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Antimicrob Agents Chemother 46:1896-905. 2002
  2. pmc Decreased clearance of CNS beta-amyloid in Alzheimer's disease
    Kwasi G Mawuenyega
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 330:1774. 2010
  3. pmc APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
    Anatoly Nikolaev
    Division of Research, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 457:981-9. 2009
  4. pmc Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    Laura M Walker
    Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 326:285-9. 2009
  5. pmc Structure of a V3-containing HIV-1 gp120 core
    Chih Chin Huang
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 310:1025-8. 2005
  6. ncbi Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
    Michael Certo
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cancer Cell 9:351-65. 2006
  7. ncbi BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
    Tomomi Kuwana
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Mol Cell 17:525-35. 2005
  8. ncbi Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    Pascale N Lacor
    Neurobiology and Physiology Department, Northwestern University, Evanston, Illinois 60208, USA5
    J Neurosci 24:10191-200. 2004
  9. pmc Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
    Leslie M Shaw
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Neurol 65:403-13. 2009
  10. ncbi Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    D Schenk
    Elan Pharmaceuticals, South San Francisco, California 94080, USA
    Nature 400:173-7. 1999

Detail Information

Publications325 found, 100 shown here

  1. pmc Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy
    Xiping Wei
    Howard Hughes Medical Institute, Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Antimicrob Agents Chemother 46:1896-905. 2002
    ..These findings provide the first evidence for the rapid emergence of clinical resistance to a novel class of HIV-1 entry inhibitors and may be relevant to future treatment strategies involving these agents...
  2. pmc Decreased clearance of CNS beta-amyloid in Alzheimer's disease
    Kwasi G Mawuenyega
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 330:1774. 2010
    ..On average, there were no differences in Aβ40 or Aβ42 production rates. Thus, the common late-onset form of Alzheimer's disease is characterized by an overall impairment in Aβ clearance...
  3. pmc APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
    Anatoly Nikolaev
    Division of Research, Genentech, Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 457:981-9. 2009
    ..Our results indicate that APP and DR6 are components of a neuronal self-destruction pathway, and suggest that an extracellular fragment of APP, acting via DR6 and caspase 6, contributes to Alzheimer's disease...
  4. pmc Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    Laura M Walker
    Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 326:285-9. 2009
    ..The results provide a framework for the design of new vaccine candidates for the elicitation of bNAb responses...
  5. pmc Structure of a V3-containing HIV-1 gp120 core
    Chih Chin Huang
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    Science 310:1025-8. 2005
    ..The extended nature and antibody accessibility of V3 explain its immunodominance. Together, the results provide a structural rationale for the role of V3 in HIV entry and neutralization...
  6. ncbi Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
    Michael Certo
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Cancer Cell 9:351-65. 2006
    ..Our data allow us to distinguish a cellular state we call "primed for death," which can be determined by BH3 profiling and which correlates with dependence on antiapoptotic family members for survival...
  7. ncbi BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
    Tomomi Kuwana
    La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Mol Cell 17:525-35. 2005
    ..In this model, the simple inhibition of antiapoptotic functions is insufficient to induce apoptosis unless a direct activator of Bax or Bak is present...
  8. ncbi Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    Pascale N Lacor
    Neurobiology and Physiology Department, Northwestern University, Evanston, Illinois 60208, USA5
    J Neurosci 24:10191-200. 2004
    ..Results suggest the hypothesis that targeting and functional disruption of particular synapses by Abeta oligomers may provide a molecular basis for the specific loss of memory function in early AD...
  9. pmc Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
    Leslie M Shaw
    Department of Pathology and Laboratory Medicine, Institute on Aging, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Ann Neurol 65:403-13. 2009
    ..Develop a cerebrospinal fluid biomarker signature for mild Alzheimer's disease (AD) in Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects...
  10. ncbi Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    D Schenk
    Elan Pharmaceuticals, South San Francisco, California 94080, USA
    Nature 400:173-7. 1999
    ..Our results raise the possibility that immunization with amyloid-beta may be effective in preventing and treating Alzheimer's disease...
  11. ncbi Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression
    Maria Manczak
    Neurogenetics Laboratory, Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Aveue, Beaverton, 97006, USA
    Hum Mol Genet 15:1437-49. 2006
    ..These findings suggest that early mitochondrially targeted therapeutic interventions may be effective in delaying AD progression in elderly individuals and in treating AD patients...
  12. ncbi Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Manuela Neumann
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 314:130-3. 2006
    ..TDP-43 represents the common pathologic substrate linking these neurodegenerative disorders...
  13. ncbi Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    Alain R Simard
    Laboratory of Molecular Endocrinology, CHUL Research Center and Department of Anatomy and Physiology, Laval University, 2705 Laurier Boul, Quebec G1V 4G2, Canada
    Neuron 49:489-502. 2006
    ..Therapeutic strategies aiming to improve their recruitment could potentially lead to a new powerful tool for the elimination of toxic senile plaques...
  14. doi CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    JAMA 302:385-93. 2009
    ....
  15. ncbi Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin
    G Schilling
    Department of Psychiatry, Division of Neuropathology, Johns Hopkins University, Baltimore, MD 21205 2196, USA
    Hum Mol Genet 8:397-407. 1999
    ..These findings are consistent with the idea that N-terminal fragments of huntingtin with a repeat expansion are toxic to neurons, and that N-terminal fragments are prone to form both intranuclear inclusions and neuritic aggregates...
  16. pmc Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    Robson A S Santos
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, 31270, Minas Gerais, Brazil
    Proc Natl Acad Sci U S A 100:8258-63. 2003
    ..Collectively, these findings identify Mas as a functional receptor for Ang-(1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide...
  17. ncbi The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation
    C Nilsberth
    Karolinska Institutet, Department of Neurotec, Geriatric Medicine, Novum KFC, S 141 86 Huddinge, Sweden
    Nat Neurosci 4:887-93. 2001
    ....
  18. pmc Toxic fibrillar oligomers of amyloid-β have cross-β structure
    James C Stroud
    Department of Chemistry and Biochemistry, UCLA DOE Institute for Genomics and Proteomics, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 109:7717-22. 2012
    ..Our model is consistent with numerous properties of Abeta42 fibrillar oligomers, including heterogenous size, ability to seed new populations of fibrillar oligomers, and fiber-like morphology...
  19. pmc Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of human immunodeficiency virus type 1 env V3 loop sequences
    Mark A Jensen
    Department of Microbiology, University of Washington, Seattle, Washington 98195 8070, USA
    J Virol 77:13376-88. 2003
    ..We found that X4 viruses were lost in two ways: by the dying off of an established X4 lineage or by mutation back to low-scoring V3 loops...
  20. pmc Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake
    Shaomin Li
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuron 62:788-801. 2009
    ..In accord, synaptic glutamate uptake was significantly decreased by soluble Abeta. We conclude that soluble Abeta oligomers perturb synaptic plasticity by altering glutamate recycling at the synapse and promoting synapse depression...
  21. pmc Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus
    Daniela Puzzo
    Department of Pathology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York 10032, USA
    J Neurosci 28:14537-45. 2008
    ....
  22. pmc A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR
    Aneta T Petkova
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 0520, USA
    Proc Natl Acad Sci U S A 99:16742-7. 2002
    ..The only charged sidechains in the core are those of D23 and K28, which form salt bridges. Fibrils with minimum mass-per-length and diameter consist of two cross-beta units with their hydrophobic faces juxtaposed...
  23. doi Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia
    Peder Buchhave
    Neuropsychiatric Clinic, Skane University Hospital, Malmo, Sweden
    Arch Gen Psychiatry 69:98-106. 2012
    ..Early detection of prodromal Alzheimer disease (AD) is important because new disease-modifying therapies are most likely to be effective when initiated during the early stages of disease...
  24. ncbi Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain
    H F Dovey
    Elan Pharmaceuticals, Inc, South San Francisco, CA 94080, USA
    J Neurochem 76:173-81. 2001
    ..Development of such novel functional gamma-secretase inhibitors will enable a clinical examination of the A beta hypothesis that Ass peptide drives the neuropathology observed in Alzheimer's disease...
  25. ncbi Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report
    James A R Nicoll
    Division of Clinical Neurosciences, University of Southampton, Southampton, UK
    Nat Med 9:448-52. 2003
    ..The T-lymphocyte meningoencephalitis is likely to correspond to the side effect seen in some other patients who received AN-1792 (refs. 7-9)...
  26. pmc Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease
    Summer L Bernstein
    Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106 9510, USA
    Nat Chem 1:326-31. 2009
    ..Our results are consistent with previous observations that Aβ40 and Aβ42 self-assemble via different pathways and provide a candidate in the Aβ42 dodecamer for the primary toxic species in Alzheimer's disease...
  27. ncbi Higher-energy C-trap dissociation for peptide modification analysis
    Jesper V Olsen
    Department for Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82131 Martinsried, Germany
    Nat Methods 4:709-12. 2007
    ..Immonium ions generated via HCD pinpoint modifications such as phosphotyrosine with very high confidence. Additionally we show that an added octopole collision cell facilitates de novo sequencing...
  28. ncbi Mutations in dynein link motor neuron degeneration to defects in retrograde transport
    Majid Hafezparast
    Department of Neurodegenerative Disease, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Science 300:808-12. 2003
    ..These mutations exclusively perturb neuron-specific functions of dynein...
  29. ncbi A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
    X Cao
    The Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9111 USA
    Science 293:115-20. 2001
    ..This complex potently stimulates transcription via heterologous Gal4- or LexA-DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression...
  30. ncbi Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
    B De Strooper
    Experimental Genetics Group, Flemish Institute for Biotechnology VIB4, Center for Human Genetics, K U Leuven, Belgium
    Nature 391:387-90. 1998
    ..Our results indicate that mutations in PS1 that manifest clinically cause a gain of function and that inhibition of PS1 activity is a potential target for anti-amyloidogenic therapy in Alzheimer's disease...
  31. pmc Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio
    Inna Kuperstein
    Department for Molecular and Developmental Genetics, Flanders Institute for Biotechnology VIB, Leuven, Belgium
    EMBO J 29:3408-20. 2010
    ..Our work also suggests the dynamic nature of the equilibrium between toxic and non-toxic intermediates...
  32. ncbi Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    Lin Chen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville Victoria 3050, Australia
    Mol Cell 17:393-403. 2005
    ..The results suggest that apoptosis relies on selective interactions between particular subsets of these proteins and that it should be feasible to discover BH3-mimetic drugs that inactivate specific prosurvival targets...
  33. pmc Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease
    Koichi Iijima
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 101:6623-8. 2004
    ..Moreover, Drosophila may serve as a model for facilitating the understanding of molecular mechanisms underlying Abeta toxicity and the discovery of novel therapeutic targets for AD...
  34. ncbi Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization
    J M Orgogozo
    Federation of Neurology, CHU Pellegrin, Bordeaux, France
    Neurology 61:46-54. 2003
    ..A Phase I study in AD patients demonstrated good safety and tolerability of multiple injections of aggregated Abeta42 (AN1792) with QS-21 as adjuvant...
  35. ncbi Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease
    Stefan Barghorn
    Neuroscience Discovery Research, Abbott GmbH and Co KG, Ludwigshafen, Germany
    J Neurochem 95:834-47. 2005
    ..Selective neutralization of the Abeta globulomer structure epitope is expected to have a high potential for treatment of AD...
  36. pmc Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways
    Gal Bitan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:330-5. 2003
    ..The strong etiologic association of Abeta42 with AD may thus be a result of assemblies formed at the earliest stages of peptide oligomerization...
  37. ncbi Gut hormone PYY(3-36) physiologically inhibits food intake
    Rachel L Batterham
    Imperial College Faculty of Medicine at Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Nature 418:650-4. 2002
    ..Thus, postprandial elevation of PYY(3-36) may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway...
  38. ncbi Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils
    Aneta T Petkova
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health NIH, Bethesda, MD 20892 0520, USA
    Science 307:262-5. 2005
    ..These results have implications for the mechanism of amyloid formation, the phenomenon of strains in prion diseases, the role of amyloid fibrils in amyloid diseases, and the development of amyloid-based nano-materials...
  39. ncbi A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    D Morgan
    Department of Pharmacology, University of South Florida, Tampa 33612, USA
    Nature 408:982-5. 2000
    ..The A beta-vaccinated mice also had a partial reduction in amyloid burden at the end of the study. This therapeutic approach may thus prevent and, possibly, treat Alzheimer's dementia...
  40. pmc Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis
    Tracy O'Connor
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 60:988-1009. 2008
    ..These results strongly suggest that eIF2alpha phosphorylation increases BACE1 levels and causes Abeta overproduction, which could be an early, initiating molecular mechanism in sporadic AD...
  41. pmc Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 284:4230-7. 2009
    ..The annular anti-protofibril antibody also recognizes heptameric alpha-hemolysin pores, but not monomers, suggesting that the antibody recognizes an epitope that is specific for a beta barrel structural motif...
  42. ncbi Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 300:486-9. 2003
    ..These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity...
  43. pmc Characterization of vertebrate cohesin complexes and their regulation in prophase
    I Sumara
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    J Cell Biol 151:749-62. 2000
    ..These results suggest that vertebrate cohesins are regulated by a novel prophase pathway which is distinct from the APC pathway that controls cohesins in yeast...
  44. doi 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
    Norman R Relkin
    Department of Neurology, the Weill Cornell Medical College, New York, NY, USA
    Neurobiol Aging 30:1728-36. 2009
    ..J. Neurol. Neurosurg. Psychiatry 75, 1472-1474] from a 6-month trial of IVIg in 5 AD patients and justify further studies of IVIg for treatment of AD...
  45. pmc Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein
    Claudia Balducci
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan 20156, Italy
    Proc Natl Acad Sci U S A 107:2295-300. 2010
    ..However, PrP-expressing and PrP knock-out mice were equally susceptible to this impairment. These data suggest that Abeta(1-42) oligomers are responsible for cognitive impairment in AD and that PrP(C) is not required...
  46. pmc Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity
    Mauritius Menges
    Department of Dermatology, University of Erlangen, Erlangen 91052, Germany
    J Exp Med 195:15-21. 2002
    ..In conclusion, this study describes that stimulation by TNF-alpha results in incompletely matured DCs (semi-mature DCs) which induce peptide-specific IL-10-producing T cells in vivo and prevent EAE...
  47. ncbi Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury
    Amal K Bose
    The Hatter Institute for Cardiovascular Studies, University College London Hospital and Medical School, Grafton Way, London WC1E, UK
    Diabetes 54:146-51. 2005
    ..This protection appears to involve activating multiple prosurvival kinases. This finding may represent a new therapeutic potential for this class of drug currently undergoing clinical trials in the treatment of type 2 diabetes...
  48. ncbi Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology
    H Lin
    Neuroscience Research Institute, University of California, Santa Barbara, California 93016, USA
    FASEB J 15:2433-44. 2001
    ..Thus, AbetaP channels may provide a direct pathway for calcium-dependent AbetaP toxicity in AD...
  49. pmc The PeptideAtlas project
    Frank Desiere
    Institute for Systems Biology, Seattle, WA, USA
    Nucleic Acids Res 34:D655-8. 2006
    ..Here we present a summary of our process and details about the Human, Drosophila and Yeast PeptideAtlas builds...
  50. pmc Functional amyloid formation within mammalian tissue
    Douglas M Fowler
    Department of Chemistry, The Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, California, USA
    PLoS Biol 4:e6. 2006
    ....
  51. ncbi Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines
    Jessica Koenigsknecht-Talboo
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 25:8240-9. 2005
    ..These findings support anti-inflammatory therapies for the treatment of AD...
  52. doi Entry inhibitors in the treatment of HIV-1 infection
    John C Tilton
    Department of Microbiology, University of Pennsylvania, 301C Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, United States
    Antiviral Res 85:91-100. 2010
    ..This article forms part of a special issue of Antiviral Research marking the 25th anniversary of antiretroviral drug discovery and development, Vol 85, issue 1, 2010...
  53. ncbi A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced
    M Johnstone
    British Biotech Pharmaceuticals, Oxford, UK
    J Neuroimmunol 93:182-93. 1999
    ..We propose therefore that A beta-mediated astrocyte activation initiates an inflammatory cascade which could be targeted for therapeutic intervention in AD...
  54. ncbi Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro
    Christopher G Evans
    Department of Pathology and the Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:33182-91. 2006
    ..Thus, these results are consistent with a model in which pharmacological activation of chaperones might have a favorable therapeutic effect on Alzheimer disease...
  55. ncbi Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
    Harald H Hofstetter
    Clinical Research Group for Multiple Sclerosis, Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Cell Immunol 237:123-30. 2005
    ..Neutralization of IL-17 with a monoclonal antibody also ameliorated the disease course. We conclude that IL-17 is crucially involved in the cytokine network as an effector cytokine in EAE...
  56. ncbi Metabolic regulation of brain Abeta by neprilysin
    N Iwata
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako shi 351 0198 Japan
    Science 292:1550-2. 2001
    ..Our observations suggest that even partial down-regulation of neprilysin activity, which could be caused by aging, can contribute to AD development by promoting Abeta accumulation...
  57. doi Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort
    N S M Schoonenboom
    Departments of Neurology, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
    Neurology 78:47-54. 2012
    ..To determine how amyloid β 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) levels in CSF behave in a large cohort of patients with different types of dementia...
  58. ncbi The glucagon-like peptides
    T J Kieffer
    Department of Medicine, University of Alberta, Edmonton, Canada
    Endocr Rev 20:876-913. 1999
  59. doi Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death
    Jonas J Neher
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom
    J Immunol 186:4973-83. 2011
    ..Thus, blocking phagocytosis may prevent some forms of inflammatory neurodegeneration, and therefore might be beneficial during brain infection, trauma, ischemia, neurodegeneration, and aging...
  60. ncbi Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers
    James Shorter
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 304:1793-7. 2004
    ..These Hsp104 activities differed in their reaction mechanism and can explain [PSI+] inheritance patterns...
  61. doi Unrecognised ventricular dysfunction in COPD
    A Macchia
    Epidemiology Section, Dept of Internal Medicine, CEMIC Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina
    Eur Respir J 39:51-8. 2012
    ..Considering the high prevalence and the prognostic implications of ventricular dysfunction, routine assessment with either BNP or echocardiogram should be considered in COPD patients...
  62. ncbi Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
    S Gilman
    Department of Neurology, University of Michigan, 300 N Ingalls 3D15, Ann Arbor, MI 48109 0489, USA
    Neurology 64:1553-62. 2005
    ..The authors report the results of a phase IIa immunotherapy trial of AN1792(QS-21) in patients with mild to moderate Alzheimer disease (AD) that was interrupted because of meningoencephalitis in 6% of immunized patients...
  63. doi CSF soluble amyloid precursor proteins in the diagnosis of incipient Alzheimer disease
    R Perneczky
    Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Klinikum rechts der Isar, 81675 Munchen, Germany
    Neurology 77:35-8. 2011
    ..To explore if soluble amyloid precursor proteins (sAPP) in CSF improve the identification of patients with incipient Alzheimer disease (AD) in a group of patients with mild cognitive impairment (MCI)...
  64. ncbi Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro
    Kenjiro Ono
    Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Neurosci Res 75:742-50. 2004
    ..1-1 microM. Although the mechanism by which Cur and RA inhibit fAbeta formation from Abeta and destabilize preformed fAbeta in vitro remains unclear, they could be a key molecule for the development of therapeutics for AD...
  65. ncbi Structural basis for coreceptor selectivity by the HIV type 1 V3 loop
    Timothy Cardozo
    Department of Pharmacology and New York University School of Medicine, New York, NY 10016, USA
    AIDS Res Hum Retroviruses 23:415-26. 2007
    ..The results have additional implications for the design of HIV therapeutics, vaccines, and strategies for monitoring disease progression...
  66. doi gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment
    Mako Takami
    Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University, Kizugawa 619 0225, Japan
    J Neurosci 29:13042-52. 2009
    ..According to numerical simulation based on the successive reaction kinetics, the induction period exists. These results strongly suggest that Abeta is generated through the stepwise processing of betaCTF by gamma-secretase...
  67. ncbi Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass
    Michael R McClung
    Oregon Osteoporosis Center, Providence Portland Medical Center, Portland, OR 97213, USA
    Arch Intern Med 165:1762-8. 2005
    ..We contrasted the effects of once-daily doses of 20 mug of teriparatide and 10 mg of alendronate sodium on bone mineral density (BMD) and markers of bone turnover...
  68. ncbi Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies
    M P Lambert
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    J Neurochem 79:595-605. 2001
    ..Analogous immuno-neutralization of oligomers in humans may be a key in AD vaccines...
  69. ncbi Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease
    P D Mehta
    Department of Immunology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Arch Neurol 57:100-5. 2000
    ..However, no information is published on plasma Abeta40 and Abeta42 levels in relation to Apo E genotype or severity of dementia in sporadic AD...
  70. ncbi P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis
    Carlos Matute
    Departamento de Neurociencias, Universidad del Pais Vasco, 48940 Leioa, Spain
    J Neurosci 27:9525-33. 2007
    ..Thus, P2X(7) receptor antagonists may be beneficial for the treatment of MS...
  71. pmc IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
    Stefan Haak
    Neuroimmunology Division, Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    J Clin Invest 119:61-9. 2009
    ..We conclude therefore that both IL-17A and IL-17F, while prominently expressed by an encephalitogenic T cell population, may only marginally contribute to the development of autoimmune CNS disease...
  72. ncbi Open mass spectrometry search algorithm
    Lewis Y Geer
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    J Proteome Res 3:958-64. 2004
    ..At default thresholds, OMSSA matches more spectra from a standard protein cocktail than a comparable algorithm. OMSSA is designed to be faster than published algorithms in searching large MS/MS datasets...
  73. ncbi A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation
    Maria E Bamberger
    Alzheimer Research Laboratory, Program in Cell Biology and Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 23:2665-74. 2003
    ..Identification of the cell surface molecules that interact with Abeta fibrils and mediate their activation of intracellular signaling cascades represents a potential intervention point in the treatment of Alzheimer's disease...
  74. pmc Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis
    Shweta Mandrekar
    Alzheimer Research Laboratory, Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 29:4252-62. 2009
    ..These studies identify an important mechanism through which microglial cells participate in the maintenance of Abeta homeostasis, through their capacity to constitutively clear sAbeta peptides from the brain...
  75. pmc CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis
    B T Fife
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Exp Med 192:899-905. 2000
    ..These results suggest that CCR2 expression on host-derived mononuclear cells is critical for disease induction...
  76. ncbi Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
    Oskar Hansson
    Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, Sweden
    Lancet Neurol 5:228-34. 2006
    ..Here, we assess the association between CSF biomarkers and incipient Alzheimer's in patients with mild cognitive impairment (MCI)...
  77. ncbi Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology
    Annika Olsson
    Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Clin Chem 51:336-45. 2005
    ....
  78. pmc GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42
    Lisa Marie Munter
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Berlin, Germany
    EMBO J 26:1702-12. 2007
    ..The results demonstrate that dimerization of APP TMS is a risk factor for AD due to facilitating Abeta42 production...
  79. pmc Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus
    John J Dwyer
    Trimeris Inc, 3500 Paramount Parkway, Morrisville, NC 27560, USA
    Proc Natl Acad Sci U S A 104:12772-7. 2007
    ..The potent antiviral activity against resistant viruses, the difficulty in generating resistant virus, and the extended half-life in vivo make this class of fusion inhibitor peptide attractive for further development...
  80. doi Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis
    Robson A S Santos
    Department of Physiology, Federal University of Minas Gerais, Belo Horizonte, MG, 31 270 901, Brazil
    Exp Physiol 93:519-27. 2008
    ..In this review, we will focus on the recent findings related to the ACE2-Ang(1-7)-Mas axis and, in particular, on its putative role as an ACE-Ang II-AT(1) receptor counter-regulatory axis within the RAS...
  81. ncbi RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
    Rashid Deane
    Frank P Smith Laboratories for Neurosurgery, Department of Neurosurgery and Division of Neurovascular Biology, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Nat Med 9:907-13. 2003
    ..These findings suggest that vascular RAGE is a target for inhibiting pathogenic consequences of Abeta-vascular interactions, including development of cerebral amyloidosis...
  82. ncbi Atomic structures of amyloid cross-beta spines reveal varied steric zippers
    Michael R Sawaya
    Howard Hughes Medical Institute, UCLA DOE Institute of Genomics and Proteomics, Los Angeles, California 90095 1570, USA
    Nature 447:453-7. 2007
    ..Structures of 13 of these microcrystals all reveal steric zippers, but with variations that expand the range of atomic architectures for amyloid-like fibrils and offer an atomic-level hypothesis for the basis of prion strains...
  83. pmc Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils
    Mahiuddin Ahmed
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, USA
    Nat Struct Mol Biol 17:561-7. 2010
    ....
  84. pmc Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    R B DeMattos
    The Center for the Study of Nervous System Injury, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:8850-5. 2001
    ..Although peripheral administration of m266 to PDAPP mice markedly reduces A beta deposition, m266 did not bind to A beta deposits in the brain. Thus, m266 appears to reduce brain A beta burden by altering CNS and plasma A beta clearance...
  85. ncbi Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease
    T E Golde
    Department of Pharmacology, Mayo Clinic Jacksonville, FL 32224, USA
    Biochim Biophys Acta 1502:172-87. 2000
    ..This review will highlight those aspects of Abeta biology that have led to our increased understanding of the pathogenesis of AD as well as areas which warrant additional study...
  86. ncbi Selective differentiation of neural progenitor cells by high-epitope density nanofibers
    Gabriel A Silva
    Institute for Bioengineering and Nanoscience in Advanced Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 303:1352-5. 2004
    ..This rapid selective differentiation is linked to the amplification of bioactive epitope presentation to cells by the nanofibers...
  87. pmc Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
    Juha Lauren
    Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    Nature 457:1128-32. 2009
    ..Thus, PrP(C) is a mediator of amyloid-beta-oligomer-induced synaptic dysfunction, and PrP(C)-specific pharmaceuticals may have therapeutic potential for Alzheimer's disease...
  88. ncbi Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
    Maria Paz Ocaranza
    Departamento Enfermedades Cardiovasculares, Escuela de Medicina, P Universidad Catolica de Chile
    Hypertension 48:572-8. 2006
    ..These findings suggest that in this second arm of the renin-angiotensin system, ACE2 may act through Ang-(1-9), rather than Ang-(1-7), as a counterregulator of the first arm, where ACE catalyzes the formation of Ang II...
  89. ncbi Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7)
    Justin L Grobe
    Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610 0487, USA
    Am J Physiol Heart Circ Physiol 292:H736-42. 2007
    ....
  90. ncbi A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
    Giselle P Lim
    Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 25:3032-40. 2005
    ..Together, these results suggest that dietary DHA could be protective against beta-amyloid production, accumulation, and potential downstream toxicity...
  91. pmc The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol
    Paul J Barrett
    Department of Biochemistry, Center for Structural Biology and Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 USA
    Science 336:1168-71. 2012
    ..The structure and cholesterol binding properties of C99 may aid in the design of Alzheimer's therapeutics...
  92. ncbi Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase
    Andrey Y Abramov
    Mitochondrial Biology Group, Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 24:565-75. 2004
    ....
  93. doi Towards a systems understanding of MHC class I and MHC class II antigen presentation
    Jacques Neefjes
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nat Rev Immunol 11:823-36. 2011
    ..The continuing flow of new details into our understanding of the biology of MHC class I and class II antigen presentation builds a system involving several cell biological processes, which is discussed in this Review...
  94. ncbi Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap
    Jesper V Olsen
    Center for Experimental Bioinformatics CEBI, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    Mol Cell Proteomics 4:2010-21. 2005
    ..High and routine mass accuracy in a compact instrument will dramatically improve certainty of peptide and small molecule identification...
  95. pmc Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry
    Mike Westby
    Globel Research and Development, Pfizer Ltd, Sandwich Labs, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom
    J Virol 81:2359-71. 2007
    ..This hypothesis was further corroborated by the observation that a high concentration of maraviroc blocks the activity of aplaviroc against maraviroc-resistant virus...
  96. ncbi The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection
    F Cocchi
    Institute of Human Virology, University of Maryland Biotechnology Institute and School of Medicine, Baltimore, Maryland 21201, USA
    Nat Med 2:1244-7. 1996
    ..The ability of the chemokines to block the early steps of HIV infection could be exploited to develop novel therapeutic approaches for AIDS...
  97. pmc Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4
    Chih Chin Huang
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 317:1930-4. 2007
    ....
  98. pmc Structure of the cross-beta spine of amyloid-like fibrils
    Rebecca Nelson
    Howard Hughes Medical Institute, UCLA DOE Institute for Genomics and Proteomics, Box 951570, UCLA, Los Angeles, California 90095 1570, USA
    Nature 435:773-8. 2005
    ..The structure illuminates the stability of amyloid fibrils, their self-seeding characteristic and their tendency to form polymorphic structures...
  99. pmc Value of using multiple proteases for large-scale mass spectrometry-based proteomics
    Danielle L Swaney
    Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Proteome Res 9:1323-9. 2010
    ....
  100. ncbi T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire
    Vijay K Kuchroo
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 20:101-23. 2002
    ..This provides a mechanism by which the fidelity and specificity of the immune system against foreign antigens is improved without increasing the potential for developing an autoimmune disease...
  101. ncbi Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin
    A Miyawaki
    Department of Pharmacology, University of California, San Diego, La Jolla 92093 0647, USA
    Nature 388:882-7. 1997
    ..Thus FRET between GFP mutants can monitor localized Ca2+ signals and protein heterodimerization in individual live cells...

Research Grants63

  1. B FORSYTHUS PROTEASE AND SIALIDASE--GENES AND SUBSTRATES
    MARK MAIDEN; Fiscal Year: 2003
    ..The protease has been partially purified and peptide fragments for sequencing have been generated. Additional new data shows that B...
  2. Histone proline isomerization and gene regulation
    Nobuaki Kikyo; Fiscal Year: 2010
    ..relationship among phosphorylation, methylation and isomerization of histones will be investigated by using peptide fragments, chromatin and living cells...
  3. The role of peroxidasin in Goodpasture's disease
    ABRAHAM SCOTT MCCALL; Fiscal Year: 2013
    ..function and normal cross-linking which would lead to proteolysis and self-immunization with auto-antigenic peptide fragments. The objective of this particular proposal is to determine peroxidasin's role in the pathogenesis of ..
  4. Streptococcus pneumoniae genetic competence and pathogenesis
    Michael E Sebert; Fiscal Year: 2011
    ..in this aim will test the model that digestion of the competence-stimulating peptide by HtrA releases peptide fragments that inhibit further signaling through the competence pathway...
  5. Drug Delivery to CNS Endothelial Cells by Targeting Peptide-MHC Complexes
    Ulrich Bickel; Fiscal Year: 2009
    ..Peptide-MHC complexes are formed from a vast variety of endogenous peptide fragments and different alleles of MHC class I molecules, and are physiologically recognized by T-cell receptors (TCR)...
  6. Brain specific non-AT1, non-AT2 angiotensin binding site
    ROBERT CHARLES SPETH; Fiscal Year: 2010
    ..With the recognition of functionality of peptide fragments of angiotensin II some having their own receptors, it is now known that brain angiotensins have a multitude ..
  7. Histone isomerization and pluripotency
    Nobuaki Kikyo; Fiscal Year: 2013
    ..relationship among phosphorylation, methylation and isomerization of histones will be investigated by using peptide fragments, chromatin and living cells...
  8. Selective Protein Capture by Epitope Imprinting
    Kenneth J Shea; Fiscal Year: 2012
    ..than the more complex secondary and tertiary structure of a target protein and is similar to the use of peptide fragments to generate epitope selective antibodies and synthetic materials...
  9. The Biology of Genetic Variants in Human Kidney Disease
    JOHN F O'TOOLE; Fiscal Year: 2013
    ..overall hypothesis is that loss of XPNPEP3 function increases the degradation of mitochondrial proteins to peptide fragments, which are transported into the cytosol where they upregulate TOR activity...
  10. Structures and Properties of Polyglutamine Proteins and Their Aggregates
    RONALD B WETZEL; Fiscal Year: 2013
    ..previous terms of this grant, our group has taken a reductionist approach to this problem, working with peptide fragments that are accessible by chemical synthesis...
  11. Discovery and Targeting of West Nile Virus Epitopes
    William Hildebrand; Fiscal Year: 2013
    ..Class I HLA molecules expose a viral infection by first sampling peptide fragments of proteins within the cell...
  12. Structure-Function of the Epithelial Sodium Channel (ENaC)
    WENDI MARJENE DAVID; Fiscal Year: 2013
    ..Binding of peptide fragments predicted to be essential for maintaining intersubunit interactions will be investigated first, followed by ..
  13. Engineering High-Affinity T Cell Receptors Against Cancer Antigens
    Daniel Harris; Fiscal Year: 2013
    ..T cells express T cell receptors (TCRs), which specifically recognize short peptide fragments bound to major histocompatibility complex (MHC) molecules on the cell surface...
  14. Regulation of the Unfolded Protein Response after Acute Brain Injury
    James D Lechleiter; Fiscal Year: 2013
    ..and biophysical techniques will be used to map the binding interaction of CN and PERK and to generate the peptide fragments. Primary cultures of astrocytes will be used to test the efficacy of these molecular interventions in vivo...
  15. Testing cell autonomy of AD phenotypes using human IPS cells
    Lawrence S Goldstein; Fiscal Year: 2013
    ..hypothesis for AD initiation and progression is the amyloid cascade hypothesis, which proposes that Ass peptide fragments of human APP are necessary and sufficient to initiate and to drive all downstream pathologies typical of AD ..
  16. Structure and mechanism of signal peptide peptidase
    Michael S Wolfe; Fiscal Year: 2010
    ..to the presenilins and is exemplified by signal peptide peptidase (SPP), which cleaves remnant signal peptide fragments left in the membrane after the action of signal peptidase...
  17. NCL with induced a-Helices: de Novo Chemical Synthesis of the ATAD2 bromodomain
    GARDNER SILAS CREECH; Fiscal Year: 2013
    ..Generally, the efficiency of ligation of peptide fragments decreases with increasing peptide length, where peptide aggregation is an often observed obstacle...
  18. Structural Characterization of Amyloid Fibrils Using Deep UV Raman Spectroscopy
    Igor K Lednev; Fiscal Year: 2013
    ..Solid-state NMR and X-ray microcrystallography applied to short peptide fragments of amyloidogenic proteins have contributed greatly to our knowledge about the fibril core structure...
  19. Calmodulation of Auditory Potassium Channels
    William R Kobertz; Fiscal Year: 2013
    ..Although there are many informative high resolution structures of calmodulin bound to peptide fragments derived from ion channels, the location of calmodulin on functioning channels and the calcium-induced ..
  20. Diagnostic peptide-nanoparticle probes for profiling tumor protease activity
    Gabriel A Kwong; Fiscal Year: 2012
    ..protease-specific peptide libraries to tumors whereupon selective cleavage by active proteases releases peptide fragments that are cleared by the renal system into urine...
  21. ANTIGENIC STRUCTURE OF PURIFIED HOUSE DUST MITE ALLERGEN
    Martin Chapman; Fiscal Year: 1992
    ..will be carried out by comparing antibody binding to denatured allergens, chemically modified allergens and peptide fragments. The aim will be to determine the repertoire of B cell epitopes, whether they are sequential or topographic ..
  22. PROTEINS OF CANDIDA ALBICANS AN AIDS-RELATED PATHOGEN
    Paula Sundstrom; Fiscal Year: 1993
    ..the amino acid sequence predicted by the cDNA insert will be compared to the internal amino acid sequence of peptide fragments of the purified hyphal surface protein...
  23. BIOCHEMICAL PROBES OF THE ACTIVE SITE OF AROMATASE
    ROBERT BRUEGGEMEIER; Fiscal Year: 1993
    ..The amino acid sequence of radiolabeled peptide fragments will be determined by microsequence analysis...
  24. Identification and characterization of cellular mechanisms which selectively cont
    BRIAN PAUL DOLAN; Fiscal Year: 2013
    ..While the peptide fragments may be derived due to the natural turnover of proteins within the cell, peptide-MHC complexes can be ..
  25. REGULATION OF THE NA+/K+ 2C1 COTRANSPORTER PROTEIN
    David Mount; Fiscal Year: 1999
    ..Two dimensional electrophoresis and autoradiography of radiolabeled rBSC peptide fragments will be used to identify residues phosphorylated by PKA and PKC...
  26. DEFINITION OF FUNCTIONAL SITES ON COAGULATION FACTOR X
    WILLIAM CHURCH; Fiscal Year: 1993
    ..The approach is to use isolated peptide fragments of Factor X, synthetic peptides from the known sequence of Factor X, and antibodies to specific topographic ..
  27. STUDIES ON ADENOSINE TRIPHOSPHATE TRANSPHOSPHORYLASES
    THOMAS ALBER; Fiscal Year: 1990
    1) The two peptide fragments derived from the front and the tail of rabbit muscle myokinase possess remarkable and specific ligand-binding properties...
  28. IDENTIFICATION OF NATURALLY PROCESSED SMANSONI PEPTIDES
    Philip Loverde; Fiscal Year: 2001
    ..as macrophages and B-lymphocytes and are processed within these cells by unfolding and proteolysis to short peptide fragments. These fragments are then displayed on the cell surface, bound to MHC class II molecules...
  29. CHEMICAL AND BIOCHEMICAL APPLICATIONS OF OXIMES
    EMIL KAISER; Fiscal Year: 1980
    We are focusing our effects on developing the synthesis of protected peptide fragments on solid supports using amino acid esters of oximes as the anchoring groups...
  30. THE ROLE OF MYELIN PROTEINS IN EXPERIMENTAL NEURITIS
    Steven Brostoff; Fiscal Year: 1990
    ..By isolating immunogenic peptide fragments, we will localize the antigenic and neuritogenic determinants, and investigate the properties of these ..
  31. INTRACELLULAR TRANSPORT PATHWAYS FOR PROCESSING ANTIGENS
    KATHLEEN MCCOY; Fiscal Year: 1993
    The processing of soluble protein antigens to peptide fragments by antigen-presenting cells (APCs) is usually required for the stimulation of CD4+ T cells. The mechanism and location whereby APCs produce antigenic peptides are unclear...
  32. Complex Formation and Protease Specificity
    Dieter Bromme; Fiscal Year: 2006
    ..at multiple intra-helical sites and similar to bacterial collagenases produces low molecular weight peptide fragments from type I and II collagens...
  33. CORTICOSTEROID CONTROL OF COLONIC CATION TRANSPORT
    CHRISTINE BASTL; Fiscal Year: 1990
    ..IB will be purified for determination of its physical characteristics and amino acid sequence of its peptide fragments. These characteristics will be compared to those of the classic receptor II...
  34. MOLECULAR CHARACTERIZATION OF A BFGF-BINDING PROTEOGLYCA
    Christopher Ross; Fiscal Year: 1991
    ..The specific aims of the proposed studies are: 1. Obtain partial amino acid sequences from peptide fragments of the core protein from cardiac bFGF-binding proteoglycan...
  35. PRIMARY STRUCTURE OF THE CYCLIC AMP RECEPTOR PROTEIN
    David Schlesinger; Fiscal Year: 1980
    ..Overlapping sequences of all these peptide fragments of CRP will be used to align the CRP amino acid sequence...
  36. PATHOBIOLOGICAL DETERMINANTS OF ATHEROSCLEROSIS IN YOUTH
    Edward Miller; Fiscal Year: 1992
    ..effective in quantitatively solubilizing collagens in vascular tissue, the collagens will be solubilized as peptide fragments utilizing specific chemical cleavage with CNBr...
  37. EPENDYMIN, AN EXTRACELLULAR PROTEIN, & NEURAL FUNCTION
    VICTOR SHASHOUA; Fiscal Year: 1990
    ..The composition and sequence of the glycan and peptide fragments, generated by protease digests, of the molecule will be determined...
  38. Analytical Methods for Investigating Peptide Transport
    SUSAN LUNTE; Fiscal Year: 2007
    ..taken back up by neurons following their release but are metabolized in the extracellular space into smaller peptide fragments. These fragments can directly affect the cells in the extracellular space in the surrounding area, pass ..
  39. ZEAMATIN--POSSIBLE HUMAN THERAPEUTIC ANTIFUNGAL AGENT
    Claude Selitrennikoff; Fiscal Year: 1990
    ..Finally, we will determine if peptide fragments of zeamatin have antifungal activity...
  40. ANTIMICROBIAL PEPTIDES OF LEUKOCYTES
    Robert Lehrer; Fiscal Year: 1999
    ..To accomplish this specific aim, well-characterized synthetic peptide fragments will be tested for their ability to protect against LPS-mediated endotoxin shock in mice...
  41. PROCESSING OF CHROMOGRANIN A BY THE FIBRINOLYTIC SYSTEM
    ROBERT PARMER; Fiscal Year: 2001
    ..vesicles, chromogranin A (CgA), and the plasminogen/t-PA system, resulting in generation of active CgA peptide fragments which modulate (inhibit) catecholamine secretion. During the first 2...
  42. Model Vaccines Exploiting Fungal Mannosylation
    STUART LEVITZ; Fiscal Year: 2009
    ..MR) on dendritic cells (DC) bind to MP, resulting in the efficient uptake, processing and presentation of peptide fragments of MP by DC...
  43. 'ROLE OF SELF-PEPTIDES IN THE SELECTION OF T LYMPHOCYTES
    Philip Ashton Rickardt; Fiscal Year: 2005
    ..The T lymphocytes antigen receptor (TCR) recognizes virally infected cells by detecting peptide fragments of virus, expressed on the surface of cells in complexes with self-MHC (Major Histocompatibility Complex) ..
  44. Antigen delivery using novel Fc receptor ligands
    David White; Fiscal Year: 2005
    ..Additionally, immune responses directed against single molecules or peptide fragments in alum are often weak...
  45. Traffic of catecholamine storage vesicle proteins
    Laurent Taupenot; Fiscal Year: 2005
    ..Granins also function as pro-hormones, giving rise by proteolytic processing to a large array of peptide fragments for which diverse autocrine, paracrine, and endocrine activities have been demonstrated in vitro, ex vivo ..
  46. H2 ANTIGENS AND MOUSE T CELL RESPONSES
    CHARLES JANEWAY; Fiscal Year: 1999
    ..These T-cells are activated by recognizing antigen in the form of peptide fragments bound to class II MHC molecules on the surface of another cell...
  47. "MSM" A multi-scale approach for understanding antigen presentation in immunity
    Denise Kirschner; Fiscal Year: 2007
    ..Antigen presentation s critical to the immune response and is the process by which peptide fragments of pathogens are taken up by cells and displayed on the cell surface...
  48. CHARACTERIZATION OF PEPTIDE BINDING PROPERTIES OF HLA
    PAMELA BJORKMAN; Fiscal Year: 1992
    The cellular immune response against viruses involves cytotoxic T cell recognition of viral peptide fragments bound to class I MHC molecules...
  49. ENZYME ACTIVE SITE MAPPING UTILIZING CARBONIUM IONS
    EMIL WHITE; Fiscal Year: 1990
    ..used are: inhibition, reduction and alkylation, G-75 Sephadex separation of the peptides, sequencing of the peptide fragments formed as a result of O-alkylation of amide linkages, chemical modification of intact C-chain to increase ..
  50. BASIC AND CLINICAL INTERVENTION IN OVARIAN FAILURE
    Denise Faustman; Fiscal Year: 1999
    ..Recently, investigators have identified a functional defect in endogenous presentation of self-peptide fragments in the groove of major histocompatibility complex (MHC) class I molecules in patients with autoimmune ..
  51. PURIFICATION OF FSH BINDING INHIBITORS
    Patrick Sluss; Fiscal Year: 1992
    ..Synthetic peptide fragments of FSH beta subunit or high MW FSH binding inhibitor and antibodies against these synthetic peptides will be ..
  52. MEMBRANES AND PHOSPHOLIPIDS IN RENAL HYPERPLASIA
    FREDERICK TOBACK; Fiscal Year: 1992
    ..Amino acid microsequencing of five of the peptide fragments revealed that the modifier is a novel protein...
  53. TANDEM MASS SPECTROMETER
    DANIEL KNAPP; Fiscal Year: 2001
    ..The requested Q-- TOF instrument will be used primarily for analysis of peptide fragments of proteins isolated by gel electrophoresis with increased sensitivity, resolution, and mass accuracy ..
  54. MAPPING SURFACE CONTACTS IN BIOMACROMOLECULE COMPLEXES
    Alan Marshall; Fiscal Year: 2000
    ..and protein complexes in solution followed by rapid quenching, enzymatic cleavage to produce dozens of peptide fragments, and prompt ultra high-resolution mass analysts to determine extend of deuterium incorporation (and thus ..
  55. AH RECEPTOR ANATOMY--IMPLICATIONS FOR DIOXIN TOXICITY
    Cornelis Elferink; Fiscal Year: 2000
    ..Amino acid microsequencing on several peptide fragments from the purified 110 kDa protein permits design of degenerate oligonucleotides intended for use in either ..
  56. A Novel Scrambled Antigen DNA Vaccine (SAVINE) Strategy
    Michael Murphey Corb; Fiscal Year: 2003
    ..SAVINE vaccines are composed of randomly rearranged overlapping peptide fragments (30 amino acids overlapping by 15 amino acids) from all viral structural and regulatory genes using a ..
  57. X RAY GUIDED DRUG DELIVERY SYSTEMS BY APCITIDE
    Dennis Hallahan; Fiscal Year: 2001
    ..Ligands that bind to alpha-2b-beta3 (a2bB3) include fibronectin and fibrinogen and peptide fragments from those proteins...
  58. MIDCAREER INVESTIGATOR AWARD IN PATIENT ORIENTED RESEARC
    MARY DISIS; Fiscal Year: 2004
    ..Furthermore, we have a more detailed understanding of how T-cells recognize antigens, as peptide fragments presented in human MHC molecules...
  59. ONCOGENE-SPECIFIC IMMUNE RESPONSES IN BREAST CANCER
    David Carbone; Fiscal Year: 1999
    ..It is now known that cytotoxic T lymphocytes (CTL) detect target cells for killing by recognizing short peptide fragments of endogenous proteins which are presented to them by class I MHC molecules on the surface of the target ..
  60. Estrogen Regulated Genes and Neural Protection
    Cheryl Sisk; Fiscal Year: 2001
    ..Presenilins promote neural degeneration by cleaving APP into plaque-forming beta-amyloid peptide fragments (Abeta42) and inducing apoptosis. In contrast, TTR impedes plaque formation by sequestering Abeta42...
  61. Identification of Neuroactive Peptides protective against Alzheimer's disease
    TREVOR TWOSE; Fiscal Year: 2006
    ..The activation by neuroactive peptide fragments of APP will be demonstrated...
  62. Mimic Peptides of HIV-1 Epitopes as Vaccines
    Darcy Wilson; Fiscal Year: 2005
    ..Current vaccine trials consist of immunization with attenuated native virus, virion proteins or their peptide fragments; so far none have proven to be successful. Stronger immunogens are required...
  63. ENDOSOMAL PROTEOLYSIS IN ANTIGEN PRESENTATION
    STEPHANIE DIMENT; Fiscal Year: 1993
    ..of events which leads from initial recognition of a non-antigenic protein by an APC to presentation of peptide fragments as antigens is less well understood...