dynorphins

Summary

Summary: A class of opioid peptides including dynorphin A, dynorphin B, and smaller fragments of these peptides. Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters.

Top Publications

  1. pmc Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion
    Michael N Lehman
    Department of Anatomy and Cell Biology, Medical Sciences Building, University of Western Ontario, London, Ontario, Canada
    Endocrinology 151:3479-89. 2010
  2. pmc Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
    Victor M Navarro
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Neurosci 29:11859-66. 2009
  3. ncbi Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat
    Yoshihiro Wakabayashi
    Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    J Neurosci 30:3124-32. 2010
  4. pmc Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight
    Melinda A Mittelman-Smith
    Department of Pathology and the Evelyn F McKnight Brain Institute, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    Endocrinology 153:2800-12. 2012
  5. ncbi Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B
    Robert L Goodman
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia, USA
    Endocrinology 148:5752-60. 2007
  6. pmc Neurokinin B and the hypothalamic regulation of reproduction
    Naomi E Rance
    Department of Pathology, and the Evelyn F McNight Brain Research Institute, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Brain Res 1364:116-28. 2010
  7. ncbi Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats
    Mark S Todtenkopf
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, MRC 217, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 172:463-70. 2004
  8. pmc Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse
    V M Navarro
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Endocrinology 152:4265-75. 2011
  9. ncbi Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheep
    Robert L Goodman
    Department of Physiology and Pharmacology, Health Sciences Center North, Medical Center Drive, Morgantown, West Virginia 26506 9229, USA
    Endocrinology 145:2959-67. 2004
  10. ncbi Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects
    Yukihiko Shirayama
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan
    J Neurochem 90:1258-68. 2004

Detail Information

Publications232 found, 100 shown here

  1. pmc Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion
    Michael N Lehman
    Department of Anatomy and Cell Biology, Medical Sciences Building, University of Western Ontario, London, Ontario, Canada
    Endocrinology 151:3479-89. 2010
    ..Taken together, this evidence suggests a key role for the KNDy subpopulation as a focal point in the control of reproductive function in health and disease...
  2. pmc Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
    Victor M Navarro
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Neurosci 29:11859-66. 2009
    ..We propose a model whereby NKB and dynorphin act autosynaptically on kisspeptin neurons in the Arc to synchronize and shape the pulsatile secretion of kisspeptin and drive the release of GnRH from fibers in the median eminence...
  3. ncbi Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat
    Yoshihiro Wakabayashi
    Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan
    J Neurosci 30:3124-32. 2010
    ....
  4. pmc Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight
    Melinda A Mittelman-Smith
    Department of Pathology and the Evelyn F McKnight Brain Institute, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    Endocrinology 153:2800-12. 2012
    ..These data provide evidence that arcuate KNDy neurons are essential for tonic gonadotropin secretion, the rise in LH after removal of E(2), and the E(2) modulation of body weight...
  5. ncbi Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B
    Robert L Goodman
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia, USA
    Endocrinology 148:5752-60. 2007
    ..Because virtually all of these neurons express estrogen and progesterone re-ceptors, they are likely to relay the feedback effects of these steroids to GnRH neurons to regulate reproductive function...
  6. pmc Neurokinin B and the hypothalamic regulation of reproduction
    Naomi E Rance
    Department of Pathology, and the Evelyn F McNight Brain Research Institute, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Brain Res 1364:116-28. 2010
    ..Future studies will be needed to determine whether NKB signaling plays a permissive role in the onset of puberty or is part of the driving force initiating the maturation of reproductive function...
  7. ncbi Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats
    Mark S Todtenkopf
    Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, MRC 217, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 172:463-70. 2004
    ..Furthermore, each effect appears due to increases in CREB-mediated expression of dynorphin, since each is attenuated by intracranial injections of the kappa-opioid receptor antagonist norBNI...
  8. pmc Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse
    V M Navarro
    Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA
    Endocrinology 152:4265-75. 2011
    ....
  9. ncbi Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheep
    Robert L Goodman
    Department of Physiology and Pharmacology, Health Sciences Center North, Medical Center Drive, Morgantown, West Virginia 26506 9229, USA
    Endocrinology 145:2959-67. 2004
    ....
  10. ncbi Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects
    Yukihiko Shirayama
    Department of Neuropsychiatry, Faculty of Medicine, Tottori University, Yonago, Japan
    J Neurochem 90:1258-68. 2004
    ..These results indicate that both dynorphin A and dynorphin B contribute to the effects of stress, and suggest that blockade of kappa-opioid receptors may have therapeutic potential for the treatment of depression...
  11. ncbi The inhibitory effects of neurokinin B on GnRH pulse generator frequency in the female rat
    James S Kinsey-Jones
    Division of Women s Health, School of Medicine, King s College London, Guy s Campus, London SE1 1UL, United Kingdom
    Endocrinology 153:307-15. 2012
    ..These data show that NKB suppresses the frequency of the GnRH pulse generator in a Dyn/κ opioid receptor-dependent fashion...
  12. pmc Activation of κ opioid receptors increases intrinsic excitability of dentate gyrus granule cells
    Carmel M McDermott
    Department of Cell and Molecular Biology, Tulane University, 6400 Freret St, New Orleans, LA 70118, USA
    J Physiol 589:3517-32. 2011
    ..2 subunit protein at the cell surface. These results are consistent with an increase in cell excitability in response to KOR activation and may reflect new possibilities for additional opioid functions...
  13. ncbi Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance
    Xuan V Nguyen
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, 800 Rose Street, 310 Whitney Henrickson Facility, Lexington, Kentucky 40536, USA
    Behav Brain Res 161:254-62. 2005
    b>Dynorphins, endogenous kappa-opioid agonists widely expressed in the central nervous system, have been reported to increase following diverse pathophysiological processes, including excitotoxicity, chronic inflammation, and traumatic ..
  14. ncbi The endogenous opioid system in human alcoholics: molecular adaptations in brain areas involved in cognitive control of addiction
    Igor Bazov
    Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Sweden
    Addict Biol 18:161-9. 2013
    ..EOS mRNAs were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and levels of dynorphins by radioimmunoassay (RIA) in post-mortem specimens obtained from 14 alcoholics and 14 controls...
  15. pmc The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 210:121-35. 2010
    ....
  16. pmc 30 years of dynorphins--new insights on their functions in neuropsychiatric diseases
    Christoph Schwarzer
    Department of Pharmacology, Innsbruck Medical University, Peter Mayr Str 1a, A 6020 Innsbruck, Austria
    Pharmacol Ther 123:353-70. 2009
    Since the first description of their opioid properties three decades ago, dynorphins have increasingly been thought to play a regulatory role in numerous functional pathways of the brain...
  17. ncbi Dynorphin displaces binding at the glycine site of the NMDA receptor in the rat striatum
    Pieter Voorn
    Department of Anatomy and Neurosciences, ICEN, Vrije Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Neurosci Lett 415:55-8. 2007
    ..This may contribute to the long-term changes in behavioral responsiveness seen after dopamine depletion and treatment with dopaminomimetics which are associated with substantial changes in striatal dynorphin metabolism...
  18. ncbi Dysregulation of dynorphins in Alzheimer disease
    T Yakovleva
    Department of Clinical Neuroscience, CMM L8 01, Karolinska Institute and Hospital, SE 17176 Stockholm, Sweden
    Neurobiol Aging 28:1700-8. 2007
    The opioid peptides dynorphins may be involved in pathogenesis of Alzheimer disease (AD) by inducing neurodegeneration or cognitive impairment...
  19. ncbi Opioid modulation of recurrent excitation in the hippocampal dentate gyrus
    G W Terman
    Departments of Anesthesiology and Pharmacology and the Graduate Program in Neurobiology and Behavior, University of Washington School of Medicine, Seattle, Washington 98195 6540, USA
    J Neurosci 20:4379-88. 2000
    ..Thus, kappa opioids can inhibit granule cell recurrent excitation, likely via effects on excitatory mossy fiber collaterals. Such collaterals are thought to be important in mediating temporal lobe epilepsy...
  20. ncbi Early modulation by the dopamine D4 receptor of morphine-induced changes in the opioid peptide systems in the rat caudate putamen
    Belen Gago
    Department of Cell Biology, School of Science, University of Malaga, Malaga, Spain
    J Neurosci Res 91:1533-40. 2013
    ..The current results present evidence of functional D4 -μ opioid receptor interactions, with consequences for the opioid peptide mRNA levels in the rat CPu, contributing to the integration of DA and opioid peptide signaling...
  21. ncbi The impact of postnatal environment on opioid peptides in young and adult male Wistar rats
    Lisa Gustafsson
    Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala University, P O Box 591, SE 751 24 Uppsala, Sweden
    Neuropeptides 42:177-91. 2008
    ..By describing effects on opioid peptides, the study addresses the possible role of a deranged endogenous opioid system in the previously described behavioral consequences of MS...
  22. pmc Non-suicidal self-injurious behavior, endogenous opioids and monoamine neurotransmitters
    Barbara Stanley
    Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, New York 10032, USA
    J Affect Disord 124:134-40. 2010
    ..This behavior, particularly when there is no apparent suicidal intent, is poorly understood from both biological and clinical perspectives...
  23. ncbi Effect of chronic ethanol on enkephalin in the hypothalamus and extra-hypothalamic areas
    Guo Qing Chang
    The Rockefeller University, New York, New York 10065, USA
    Alcohol Clin Exp Res 34:761-70. 2010
    ....
  24. pmc dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats
    Parvin Mostari
    Laboratory of Reproductive Science, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Reprod Dev 59:266-72. 2013
    ..Taken together, the present result suggests that Dyn-KOR signaling is a part of estrogen negative feedback action on GnRH/LH pulses by reducing the kisspeptin release in female rats. ..
  25. pmc Dynorphin--still an extraordinarily potent opioid peptide
    Charles Chavkin
    Department of Pharmacology, Box 357280, University of Washington, Seattle, WA 98195, USA
    Mol Pharmacol 83:729-36. 2013
    ..This article focuses on his contributions to the discovery of the dynorphins and evidence that members of this family of opioid peptides are endogenous agonists for the kappa opioid ..
  26. ncbi Long-term effects of short and long periods of maternal separation on brain opioid peptide levels in male Wistar rats
    Karolina Ploj
    Department of Pharmaceutical Biosciences, Box 591, Uppsala University, SE 751 24 Uppsala, Sweden
    Neuropeptides 37:149-56. 2003
    ..Together, these findings show that repeated periods of MS early in life in male Wistar rats affect the development of the ultrasonic call response and induce long-lasting and possibly permanent alterations in the opioid peptide systems...
  27. ncbi Cytotoxic effects of dynorphins through nonopioid intracellular mechanisms
    K Tan-No
    Section of Alcohol and Drug Addiction Research, Karolinska Institute, S-171 76 Stockholm, Sweden
    Exp Cell Res 269:54-63. 2001
    ..number of viable cells was significantly reduced when dynorphin A or "big dynorphin," consisting of dynorphins A and B, was transfected into cells...
  28. ncbi Alterations in central preproenkephalin mRNA expression after chronic free-choice ethanol consumption by fawn-hooded rats
    M S Cowen
    Abteilung Psychopharmacologie, , Mannheim, Germany
    Alcohol Clin Exp Res 25:1126-33. 2001
    ..CONCLUSIONS: The data support the putative role of opioid peptides in the effects of ethanol and suggest that the nucleus accumbens and central nucleus of the amygdala are loci for the reinforcing effects of ethanol...
  29. ncbi Dynorphins regulate fear memory: from mice to men
    Andras Bilkei-Gorzo
    Institute of Molecular Psychiatry, University of Bonn, 53125 Bonn, Germany
    J Neurosci 32:9335-43. 2012
    ..Here with a translational approach we investigated the role of dynorphins in the formation and extinction of fear memories in mice and in humans...
  30. ncbi Alterations in GAD67, dynorphin and enkephalin mRNA in striatal output neurons following priming in the 6-OHDA model of Parkinson's disease
    A Carta
    Department of Toxicology, University of Cagliari, Italy
    Neurol Sci 22:59-60. 2001
    ..These changes are in relation to the different types of dopamine agonists utilized and suggest that modifications in gene expression induced by priming might be predictive of the dyskinetic potential of a drug...
  31. ncbi Metabolism of dynorphin A(1-13)
    B Brugos
    Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville 32610, USA
    Pharmazie 59:339-43. 2004
    ..This article is a general review of the metabolism of dynorphin A(1-13) in human plasma and CSF...
  32. ncbi Membrane interactions of dynorphins
    Jesper Lind
    Department of Biochemistry and Biophysics, The Arrhenius Laboratories, Stockholm University, S 106 91 Stockholm, Sweden
    Biochemistry 45:15931-40. 2006
    The dynorphins are primarily endogenous ligands to the kappa-opioid receptor, but a variety of non-opioid effects have also been observed, including direct effects on membranes...
  33. ncbi Potent regulation of microglia-derived oxidative stress and dopaminergic neuron survival: substance P vs. dynorphin
    M L Block
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 20:251-8. 2006
    ..Here we demonstrate a tightly regulated mechanism governing microglia-derived oxidative stress, where the neuropeptide balance of dynorphin and substance P is critical to DA neuron survival...
  34. pmc Dynorphin and the pathophysiology of drug addiction
    T S Shippenberg
    Integrative Neuroscience Section, NIH NIDA Intramural Research Program, 333 Cassell Drive, Baltimore, MD 21224, USA
    Pharmacol Ther 116:306-21. 2007
    ..We will provide evidence that the repeated administration of cocaine and alcohol up-regulates the dynorphin/KOPr system and that pharmacological treatments that target this system may prove effective in the treatment of drug addiction...
  35. pmc Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats
    Brendan M Walker
    The Scripps Research Institute, La Jolla, CA, USA
    Addict Biol 16:116-9. 2011
    ..Nor-BNI decreased ethanol self-administration in ethanol-dependent animals, with no effect in nondependent animals. Thus, the κ-opioid/dynorphin system is a viable pharmacotherapeutic target for the treatment of alcoholism...
  36. ncbi Colocalization of progesterone receptors in parvicellular dynorphin neurons of the ovine preoptic area and hypothalamus
    Chad D Foradori
    Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0521, USA
    Endocrinology 143:4366-74. 2002
    ..This observation raises the possibility that an ultrashort feedback loop controls the release of DYN from ARC neurons...
  37. pmc Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23
    Georgy Bakalkin
    Department of Pharmaceutical Biosciences, Uppsala University, Sweden
    Am J Hum Genet 87:593-603. 2010
    ..PDYN is the precursor protein for the opioid neuropeptides, α-neoendorphin, and dynorphins A and B (Dyn A and B)...
  38. pmc Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats
    N Yamamoto
    Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Neuroscience 163:1171-80. 2009
    ..The results also confirm the potential usefulness of antagonists of mGluR5 receptors as adjuncts in the treatment of l-DOPA-induced dyskinesia in patients with Parkinson's disease...
  39. ncbi Ethanol-induced effects on opioid peptides in adult male Wistar rats are dependent on early environmental factors
    L Gustafsson
    Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala University, P O Box 591, SE 751 24 Uppsala, Sweden
    Neuroscience 146:1137-49. 2007
    ..The altered sensitivity of the opioid peptides to ethanol may contribute to the previously reported differences in ethanol intake between MS15 and MS360 rats...
  40. pmc Enkephalins, dynorphins, and beta-endorphin in the rat dorsal horn: an immunofluorescence colocalization study
    Juan Carlos G Marvizon
    Center for the Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Comp Neurol 517:51-68. 2009
    ..These results show that enkephalins and dynorphins are present in different populations of dorsal horn neurons. In addition, dynorphin is present in some C-fibers.
  41. ncbi Repeated ethanol administration induces short- and long-term changes in enkephalin and dynorphin tissue concentrations in rat brain
    S Lindholm
    Clinical Alcohol and Drug Addiction Research, Department of Clinical Neuroscience, Magnus Huss, M4 02, Karolinska Hospital, Karolinska Institutet, SE 171 76 Stockholm, Sweden
    Alcohol 22:165-71. 2000
    ..The results suggest that repeated ethanol administration induces both short- and long-term changes in the tissue concentrations of opioids in certain brain regions associated with motivation and reward...
  42. ncbi Aggression and the three opioid families (endorphins, enkephalins, and dynorphins) in mice
    Sylvie Tordjman
    CNRS, Génétique Neurogénétique Comportement, France
    Behav Genet 33:529-36. 2003
    ..the possible genetic relationship between intermale aggression and brain levels of enkephalins, endorphins, and dynorphins in 11 inbred strains of mice...
  43. ncbi Prenatal cannabis exposure increases heroin seeking with allostatic changes in limbic enkephalin systems in adulthood
    M Sabrina Spano
    Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, S 17176 Stockholm, Sweden
    Biol Psychiatry 61:554-63. 2007
    ..Prenatal cannabis exposure is a growing concern with little known about the long-term consequences on behavior and neural systems relevant for reward and emotional processing...
  44. ncbi Dynorphin A inhibits NMDA receptors through a pH-dependent mechanism
    Yoshio Kanemitsu
    Laboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8115, USA
    Mol Cell Neurosci 24:525-37. 2003
    ..Thus, DynA inhibits NMDA receptors through an allosteric mechanism, which is pH dependent and involves the specific structural features of the peptide...
  45. pmc The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal
    Angelo Contarino
    Dipartimento di Farmacologia e Anestesiologia, Universita degli Studi di Padova, Largo Meneghetti 2, 35131 Padua, Italy
    Proc Natl Acad Sci U S A 102:18649-54. 2005
    ..This study reveals a cardinal role for CRF/CRF1 receptor pathways in the negative affective states of opiate withdrawal and suggests therapeutic strategies for the treatment of opiate addiction...
  46. ncbi Dynorphin A(1-17) biotransformation in striatum of freely moving rats using microdialysis and matrix-assisted laser desorption/ionization mass spectrometry
    Brian Reed
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York, USA
    J Neurochem 86:815-23. 2003
    ..Additional modifications, of mass 42 and 113 Da, were also found on the N-terminus (Ile8 or Pro10) of these same C-terminal fragments. The role of these modifications of C-terminal fragments has not yet been characterized...
  47. ncbi Translocation of dynorphin neuropeptides across the plasma membrane. A putative mechanism of signal transmission
    Zoya Marinova
    Section of Alcohol and Drug Dependence Research, Department of Clinical Neuroscience, Karolinska Institute, S 17176 Stockholm, Sweden
    J Biol Chem 280:26360-70. 2005
    ..We demonstrate that dynorphin A and big dynorphin, consisting of dynorphins A and B, can penetrate into neurons and non-neuronal cells using confocal fluorescence microscopy/immunolabeling...
  48. ncbi Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    FASEB J 19:550-7. 2005
    ....
  49. ncbi Altered extracellular striatal in vivo biotransformation of the opioid neuropeptide dynorphin A(1-17) in the unilateral 6-OHDA rat model of Parkinson's disease
    Rebecka Klintenberg
    Laboratory for Biological and Medical Mass Spectrometry and Department of Pharmaceutical Biosciences, Uppsala University, Box 583, SE 75123 Uppsala, Sweden
    J Mass Spectrom 40:261-70. 2005
    ..The results imply that the extracellular in vivo processing of the dynorphin system is being disturbed in the 6-OHDA-lesion animal model of Parkinson's disease...
  50. ncbi Pathobiology of dynorphins in trauma and disease
    Kurt F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Front Biosci 10:216-35. 2005
    b>Dynorphins, endogenous opioid neuropeptides derived from the prodynorphin gene, are involved in a variety of normative physiologic functions including antinociception and neuroendocrine signaling, and may be protective to neurons and ..
  51. ncbi Big dynorphin as a putative endogenous ligand for the kappa-opioid receptor
    Florence Merg
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, France
    J Neurochem 97:292-301. 2006
    ..Big Dyn activated G proteins through KOR with much greater potency, efficacy and selectivity than other dynorphins. There was no correlation between the rank order of the potency for the KOR-mediated activation of G proteins ..
  52. pmc Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors
    Jenny E Westin
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Sweden
    Biol Psychiatry 62:800-10. 2007
    ..We examined the activation pattern of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and its dependence on D1 versus D2 dopamine receptors in hemiparkinsonian rats treated with 3,4-dihydroxyphenyl-L-alanine (L-DOPA)...
  53. ncbi Control of hormonal stress reactivity by the endogenous opioid system
    Andras Bilkei-Gorzo
    Institute of Molecular Psychiatry, University of Bonn, Sigmund Freud Street 25, 53105 Bonn, Germany
    Psychoneuroendocrinology 33:425-36. 2008
    ..These results demonstrate an important role on the endogenous opioid system in the integration of behavioral and hormonal stress responses...
  54. ncbi Dynorphin A activates bradykinin receptors to maintain neuropathic pain
    Josephine Lai
    Department of Pharmacology, University of Arizona Health Sciences Center, 1501 N Campbell Ave, Tucson, Arizona 85724, USA
    Nat Neurosci 9:1534-40. 2006
    ..These data reveal a mechanism for endogenous dynorphin to promote pain through its agonist action at bradykinin receptors and suggest new avenues for therapeutic intervention...
  55. ncbi Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation
    Sanja Darmopil
    Cajal Institute, Consejo Superior de Investigaciones Científicas and Centro de Investigación Biomédica en Red para Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain
    Biol Psychiatry 66:603-13. 2009
    ..However, pharmacologic agents for D1 or D2 receptors also recognize other receptor family members. Genetic inactivation of the dopamine D1 or D2 receptor was used to define the involvement of these receptor subtypes...
  56. ncbi Generation of dynorphin knockout mice
    N Sharifi
    Unit on Molecular Genetics, Clinical Neuroscience Branch, NIMH, 49 Convent Drive, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 86:70-5. 2001
    ..Dynorphin knockout mice constitute a valuable tool for many research areas, among them research into pain, substance abuse, and epilepsy...
  57. pmc Practical aspects of in vivo detection of neuropeptides by microdialysis coupled off-line to capillary LC with multistage MS
    Qiang Li
    Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA
    Anal Chem 81:2242-50. 2009
    ..The improvements over previous approaches using capillary LC-MS(n) make in vivo neuropeptide monitoring more practical and feasible for a variety of neuropeptides...
  58. ncbi Differential metabolism of dynorphins in substantia nigra, striatum, and hippocampus
    J Sandin
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    Peptides 18:949-56. 1997
    To map the proteolytic enzymes metabolizing dynorphins in brain structures, size-exclusion chromatography linked to electrospray ionization mass spectrometry was used...
  59. ncbi Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides
    Mohamed Khalil Tamim
    Faculty of Pharmacy, Laval University, G1K 7P4 Quebec, Canada
    Neuropharmacology 58:286-96. 2010
    ..These results show that drugs displaying a wide range of pharmacological activities can modulate L-DOPA induced dyskinesias and this activity is correlated with striatal PPD and PPE mRNA levels suggesting a convergent mechanism...
  60. ncbi Spinal cord dynorphin expression increases, but does not drive microglial prostaglandin production or mechanical hypersensitivity after incisional surgery in rats
    Xiaying Zhu
    Department of Anesthesiology, Center for the Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pain 125:43-52. 2006
    ..Although prodynorphin immunoreactivity also increases, it likely does not drive COX-1 expression or mechanical hypersensitivity in this setting...
  61. ncbi Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior
    H Steiner
    Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis 38163, USA
    Exp Brain Res 123:60-76. 1998
    ..Behavioral consequences of increased opioid peptide function in striatal output pathways may include behavioral sensitization (dynorphin) and recovery of motor function (enkephalin)...
  62. ncbi Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage
    B Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 298:1133-41. 2001
    ..b>Dynorphins are among the major opioid peptides in the striato-nigral pathway and are important in regulating dopaminergic ..
  63. ncbi The price of seizure control: dynorphins in interictal and postictal psychosis
    Marco Bortolato
    Department of Pharmacology, University of California, Irvine, Irvine, CA 92697 4292, USA
    Psychiatry Res 151:139-43. 2007
    ..In view of this background, here we introduce the hypothesis that epilepsy-related psychoses may partially result from excessive hippocampal dynorphin release and kappa opioid receptor overstimulation aimed at seizure control...
  64. pmc The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system
    Benjamin B Land
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Neurosci 28:407-14. 2008
    ..The convergence of stress-induced aversive inputs on the dynorphin system was unexpected, implicates dynorphin as a key mediator of dysphoria, and emphasizes kappa-receptor antagonists as promising therapeutics...
  65. ncbi Antagonistic effects of CompB on orphanin FQ-induced colonic contractions in rats
    Hitoshi Tada
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Eur J Pharmacol 454:53-8. 2002
    ..In contrast, CompB had no inhibitory effects on dynorphin A-induced contractions in vivo and in vitro. These indicate that CompB is a selective orphanin FQ receptor antagonist of the rat colon...
  66. ncbi Sites of action of mu-, kappa- and sigma-opiate receptor agonists at the feline ileocecal sphincter
    A Ouyang
    Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia 19104
    Am J Physiol 254:G224-31. 1988
    ..mu-Receptor activation causes ICS contraction via a cholinergic pathway...
  67. ncbi Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation
    Koichi Tan-No
    Department of Pharmacology, Tohoku Pharmaceutical University, 4 4 1 Komatsushima, Aoba ku, Sendai 981 8558, Japan
    Pain 113:301-9. 2005
    ..We have recently reported that dynorphin A and, more potently big dynorphin, consisting of dynorphins A and B, produce the same type of nociceptive response whereas dynorphin B does not [Tan-No K, Esashi A, ..
  68. ncbi A comparison between microwave irradiation and decapitation: basal levels of dynorphin and enkephalin and the effect of chronic morphine treatment on dynorphin peptides
    I Nylander
    Department of Pharmaceutical Biosciences, Uppsala University, Sweden
    Neuropeptides 31:357-65. 1997
    ....
  69. pmc Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn
    A N Carey
    Department of Psychology, Northeastern University, Boston, MA 02115, USA
    Eur J Pharmacol 569:84-9. 2007
    ..Arodyn pretreatment suppressed stress-induced, but not cocaine-exposed, reinstatement of cocaine place preference. These results verify that arodyn and other kappa-opioid receptor antagonists may be useful therapeutics for cocaine abuse...
  70. ncbi Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain
    P J Cabot
    Behavioral Pharmacology and Genetics Section, Intramural Research Program, NIDA NIH, Baltimore, MD 21224, USA
    Pain 93:207-12. 2001
    ..These studies further support a role of the immune system in the control of inflammatory pain. This may be particularly important in patients suffering from compromised immune systems as with cancer and AIDS...
  71. ncbi Opioid receptors and their ligands
    Anna Janecka
    Department of Medicinal Chemistry, Medical University of Lodz, Lodz, Poland
    Curr Top Med Chem 4:1-17. 2004
    ..Chemical modifications that led to obtaining potent and selective agonists and antagonists for these receptors are discussed...
  72. pmc Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia
    L Gendron
    Department of Pharmacology, Health Sciences Building, University of Washington, Seattle, WA 98195 7280, USA
    Neuroscience 150:807-17. 2007
    ..We therefore conclude that DOR-mediated antihyperalgesia is dependent on MOR expression but that activation of MOR by endogenous opioids is probably not required...
  73. ncbi Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice
    Kaido Kurrikoff
    Department of Physiology, University of Tartu, 19 Ravila Street, 50411 Tartu, Estonia
    Eur J Neurosci 20:1577-86. 2004
    ..Our study suggests that not only pain sensitivity, but also mechanical sensitivity and the development of neuropathic pain are regulated by antagonistic interactions between CCK and opioid systems...
  74. ncbi Behavioral and biochemical correlates of the dyskinetic potential of dopaminergic agonists in the 6-OHDA lesioned rat
    Anna R Carta
    Department of Toxicology and Center of Excellence for Neurobiology of Addiction, University of Cagliari, Cagliari, Italy
    Synapse 62:524-33. 2008
    ..In contrast, increase of GAD67 mRNA in the GP was associated to both behavioral responses (SCT and AIMs), suggesting that neuroadaptive changes in this area were unrelated to the difference in dyskinetic potential of drugs...
  75. ncbi Repeated peripheral electrical stimulations suppress both morphine-induced CPP and reinstatement of extinguished CPP in rats: accelerated expression of PPE and PPD mRNA in NAc implicated
    Xiang Dang Shi
    Neuroscience Research Institute, Key Laboratory for Neuroscience, Peking University, The Ministry of Education, 38 Xueyuan Road, Beijing 100083, PR China
    Brain Res Mol Brain Res 130:124-33. 2004
    ..These findings suggest that enkephalin and dynorphin in NAc may play important roles in the mechanisms underlying the inhibitory effect of PES on the expression and reinstatement of morphine-induced CPP in rats...
  76. ncbi Opioid receptors and acetaminophen (paracetamol)
    Robert B Raffa
    Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Eur J Pharmacol 503:209-10. 2004
    ..These findings further implicate endogenous opioids (viz., endorphins, enkephalins, and dynorphins) and their pathways as contributors to the central antinociceptive action of acetaminophen.
  77. pmc Effects of cocaine place conditioning, chronic escalating-dose "binge" pattern cocaine administration and acute withdrawal on orexin/hypocretin and preprodynorphin gene expressions in lateral hypothalamus of Fischer and Sprague-Dawley rats
    Y Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuroscience 153:1225-34. 2008
    ....
  78. ncbi Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats
    John R Mantsch
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA
    Psychopharmacology (Berl) 175:26-36. 2004
    ..The investigation of rodent cocaine self-administration (SA) under conditions that promote escalating patterns of intake may provide insight into the loss of control over drug use that is central to human addiction...
  79. pmc Increased spinal dynorphin contributes to chronic nicotine-induced mechanical hypersensitivity in the rat
    Chris Lough
    Department of Biology, Wake Forest University, Winston Salem, NC 27109, USA
    Neurosci Lett 422:54-8. 2007
    ..Our results suggest that chronic nicotine administration produces an increase in spinal dynorphin content and release that contributes to mechanical hypersensitivity...
  80. ncbi Noradrenergic and opioidergic alterations in neuropathy in different rat strains
    Gonzalo Herradon
    Pharmacology Laboratory, Universidad San Pablo CEU, Cta Boadilla Km 5300, Boadilla, Madrid 28668, Spain
    Neurosci Lett 438:186-9. 2008
    ..The data strongly suggest that dynorphins could be involved in strain differences concerning CCI resistance.
  81. pmc Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance
    Mei Xu
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195 7280, USA
    J Neurosci 24:4576-84. 2004
    ..Thus, endogenous dynorphin had both pronociceptive and antinociceptive actions after nerve injury and induced GRK3-mediated opioid tolerance...
  82. ncbi The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat
    Melinda L Cox
    Virginia Commonwealth University, Department of Pharmacology and Toxicology, Medical College of Virginia, P O Box 980613, MCV Station, Richmond, VA 23298 0613, USA
    Eur J Pharmacol 493:65-74. 2004
    ..We hypothesize that the elevated idyn A level in arthritic rats contributes to hyperalgesia by interaction with N-methyl-D-aspartate receptors, and that Delta9-THC induces antinociception by decreasing idyn A release...
  83. ncbi Neuroprotection induced by the adenosine A2A antagonist CSC in the 6-OHDA rat model of parkinsonism: effect on the activity of striatal output pathways
    Jordi Bove
    Laboratori de Neurologia Experimental, Area de Neurociències, Fundació Clínic Hospital Clínic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Villarroel 170, 08036 Barcelona, Spain
    Exp Brain Res 165:362-74. 2005
    ....
  84. ncbi The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance
    Dan Georgescu
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9070, USA
    J Neurosci 25:2933-40. 2005
    ..This work identifies a novel hypothalamic-AcSh circuit that influences appetitive behavior and mediates the antidepressant activity of MCH1R antagonists...
  85. ncbi Effect of ethanol on hypothalamic opioid peptides, enkephalin, and dynorphin: relationship with circulating triglycerides
    Guo Qing Chang
    Laboratory of Behavioral Neurobiology, The Rockefeller University, New York, New York 10021, USA
    Alcohol Clin Exp Res 31:249-59. 2007
    ..To test the hypothesis that other feeding-related systems are involved in ethanol intake, this study examined the effect of ethanol on the hypothalamic opioid peptides, enkephalin (ENK), and dynorphin (DYN)...
  86. ncbi Alterations in prodynorphin gene expression and dynorphin levels in different brain regions after chronic administration of 14-methoxymetopon and oxycodone-6-oxime
    K P Király
    Neuropsychopharmacological Group, Hungarian Academy of Sciences, H 1445 Budapest, Nagyvarad ter 4, P O Box 370, Hungary
    Brain Res Bull 70:233-9. 2006
    ....
  87. pmc Dynorphin peptides differentially regulate the human kappa opioid receptor
    Yong Chen
    Department of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, U S A
    Life Sci 80:1439-48. 2007
    b>Dynorphins, endogenous peptides for the kappa opioid receptor, play important roles in many physiological and pathological functions...
  88. ncbi Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression
    David A Jacobson
    Department of Medicine, University of Chicago, IL 60637, USA
    Am J Physiol Endocrinol Metab 291:E587-95. 2006
    ..The data provide a molecular basis for opiate stimulation of glucagon secretion first observed over 25 years ago...
  89. ncbi Dopamine D1 receptors have subcellular distributions conducive to interactions with prodynorphin in the rat nucleus accumbens shell
    Yuko Hara
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    Synapse 60:1-19. 2006
    ..They also indicate that dynorphin peptides have distributions that would enable their participation in modulation of DA release or D1R-mediated postsynaptic responses in Acb shell neurons...
  90. ncbi Reversion of levodopa-induced motor fluctuations by the A2A antagonist CSC is associated with an increase in striatal preprodynorphin mRNA expression in 6-OHDA-lesioned rats
    J Bove
    Laboratori de Neurologia Experimental, Area de Neurociències, Fundació Clínic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Synapse 59:435-44. 2006
    ....
  91. ncbi Extracellular signal-regulated mitogen-activated protein kinase inhibitors decrease amphetamine-induced behavior and neuropeptide gene expression in the striatum
    X Shi
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29425, USA
    Neuroscience 138:1289-98. 2006
    ..These data indicate that activation of the extracellular-regulated kinase cascade contributes to the behavioral effects and changes in striatal neuropeptide gene expression induced by acute amphetamine...
  92. ncbi Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats
    Elisabetta Tronci
    Department of Toxicology, University of Cagliari, Italy
    Eur J Pharmacol 566:94-102. 2007
    ..Moreover, in agreement to other well characterized adenosine A2A receptor antagonists, ST1535 features antitremorigenic effects...
  93. ncbi Reduced ethanol response in the alcohol-preferring RHA rats and neuropeptide mRNAs in relevant structures
    Marc Guitart-Masip
    Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain
    Eur J Neurosci 23:531-40. 2006
    ..RHA rats may have more predictive value than other rodent alcoholism models, as high initial tolerance to ethanol is a risk factor for alcoholism in humans...
  94. ncbi Big dynorphin, a prodynorphin-derived peptide produces NMDA receptor-mediated effects on memory, anxiolytic-like and locomotor behavior in mice
    Alexander Kuzmin
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 31:1928-37. 2006
    ..Effects of Big Dyn were inhibited by MK 801 (0.1 mg/kg), an NMDA ion-channel blocker whereas those of dynorphins A and B were blocked by the kappa-opioid antagonist nor-binaltorphimine (6 mg/kg). Big Dyn (2...
  95. ncbi Chronic and acute effects of 3,4-methylenedioxy-N-methylamphetamine ('Ecstasy') administration on the dynorphinergic system in the rat brain
    M Di Benedetto
    Department of Pharmacology, University of Bologna, Irnerio 48, 40126 Bologna, Italy
    Neuroscience 137:187-96. 2006
    ....
  96. ncbi Comparison of basal and D-1 dopamine receptor agonist-stimulated neuropeptide gene expression in caudate-putamen and nucleus accumbens of ad libitum fed and food-restricted rats
    Sandra L Haberny
    Department of Pharmacology, Millhauser Laboratories, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Brain Res Mol Brain Res 141:121-7. 2005
    ....
  97. ncbi Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats
    Véronique Sgambato-Faure
    INSERM U318, Laboratoire de Neurosciences Précliniques, CHU Pavillon B, Grenoble, France
    J Neuropathol Exp Neurol 64:936-47. 2005
    ....
  98. ncbi Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala
    Minoru Narita
    Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Shinagawa ku, Tokyo, Japan
    Neuropsychopharmacology 31:739-50. 2006
    ..Collectively, the present data constitute the first evidence that chronic pain has an anxiogenic effect in mice. This phenomenon may be associated with changes in opioidergic function in the amygdala...
  99. ncbi Opioid peptides and receptors in joint tissues: study in the rat
    Jonas Bergstrom
    Department of Molecular Medicine and Surgery, Section of Orthopaedics, Karolinska Institutet, Orthopaedic Research Laboratory, Karolinska Hospital, S 171 76 Stockholm, Sweden
    J Orthop Res 24:1193-9. 2006
    ..The endogenous opioid system now demonstrated might be targeted and exploited therapeutically to obtain peripheral control of symptoms in joint disorders...
  100. ncbi Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Brain Res 1189:70-7. 2008
    ..c.) administration. These results suggest that nicotine has an antinociceptive effect by promoting the release of Met-ENK, but not dynorphins and endorphins, from activated opioidergic neurons in spinal cord.
  101. ncbi Regional adaptations in PSD-95, NGFI-A and secretogranin gene transcripts related to vulnerability to behavioral sensitization to amphetamine in the Roman rat strains
    M Guitart-Masip
    Department of Psychiatry and Forensic Medicine, Institute of Neuroscience, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain
    Neuroscience 151:195-208. 2008
    ....

Research Grants66

  1. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..The current application will provide important new information on both efficacy and mechanism of action in acupuncture treatment of either elevated or low blood pressure. ..
  2. Opioidergic System: Its Role(s) in Glaucoma
    Shahid Husain; Fiscal Year: 2013
    ..In mammals, endogenous opioidergic peptides, such as enkephalins, dynorphins, and endorphins, are physiological modulators of neuroendocrine, immune, and inflammatory challenges that are ..
  3. The Role of Kappa Opioid Receptor-induced Activation of Astrocytes in the Reinsta
    Charles Chavkin; Fiscal Year: 2009
    ..This study would identify the connection between astrocyte activation and reinstatement of extinguished cocaine place preference by assessing the effects of selectively disrupting kappa opioid signaling in astroctyes on behavior. ..
  4. The Kiss1 system in the neuroendocrine control of reproduction
    VICTOR MANUEL NAVARRO; Fiscal Year: 2013
    ..This additional training will aid in my development of a competitive research program and contribute to my establishment as an independent investigator. ..
  5. CELLULAR AND MOLECULAR BASES FOR RHYTHMIC GNRH RELEASE
    Suzanne M Moenter; Fiscal Year: 2013
    ..We also have preliminary data supporting the equally interesting hypothesis that GnRH feeds back to inhibit KNDy neuronal networks. ..
  6. Regulation of striatal cannabinoid CB1 receptors by DARPP32 and deltaFosB mediate
    Matthew F Lazenka; Fiscal Year: 2012
    ..The proposed studies will determine the effects of repeated cannabinoid administration on biochemical messengers that regulate activity in these brain regions. ..
  7. Neurobiology of Anxiety and Panic Disorders
    Anantha Shekhar; Fiscal Year: 2013
    ....
  8. Neuropeptide Modulation of ASICs
    Candice C Askwith; Fiscal Year: 2012
    ..Recently, we discovered that dynorphins prevent ASIC1a desensitization...
  9. Roles of Nucleus Accumbens CREB and Kappa Function in Depression
    William A Carlezon; Fiscal Year: 2013
    ..We will also test the hypothesis that KOR disruption blocks stress-induced alterations in microRNA (miR) expression in the mesocorticolimbic system. This work may provide a basis for improved diagnostics and therapeutics. ..
  10. p38 MAPK Mechanisms of Kappa Opioid-Induced Aversion
    Charles Chavkin; Fiscal Year: 2013
    ....
  11. The ability of the transcription factor CREB in the Nac to regulate mood
    Ronald S Duman; Fiscal Year: 2011
    ..g., MCH in Project 3), and by characterizing their role in mediating CREB's complex behavioral phenotype related to depression and its treatment. ..
  12. Interactions of dynorphin, NKB, and kisspeptin in control of GnRH secretion
    Michael N Lehman; Fiscal Year: 2013
    ..on the mechanisms underlying GnRH secretion and the role of NKB that may lay the foundation for the development of better treatments for pathological disruptions of reproductive function, and the design of novel contraceptive techniques ..
  13. Novel Mechanisms Underlying Depression: PET Imaging of the Kappa Opioid Receptor
    Jeffrey M Miller; Fiscal Year: 2012
    ..The kappa opioid receptor (KOR) is stimulated by the endogenous kappa opioids, dynorphins, in response to stress...
  14. Sex differences in the aversive effects of kappa-opioid receptor activation
    Elena H Chartoff; Fiscal Year: 2013
    ....
  15. Pharmacological Actions of Antidepressants Treatments
    Eric J Nestler; Fiscal Year: 2013
    ....
  16. Ethanol and Peptidergic Systems in the Central Amygdala
    Scott D Moore; Fiscal Year: 2013
    ....
  17. Investigation of Neoclerodanes as Novel Opioid Ligands
    THOMAS EDWARD PRISINZANO; Fiscal Year: 2013
    ..This information is expected to facilitate the identification of clinically useful KOP-targeted drugs for the treatment of drug abuse and other neuropsychiatric disorders. ..
  18. Pseudomonas'effects on the gut barrier from surgery
    John C Alverdy; Fiscal Year: 2012
    ..aeruginosa expresses a lethal phenotype against the intestinal epithelium and identify novel therapeutic targets and non-antibiotic compounds that molecularly silence this pathogen from expressing a lethal phenotype. ..
  19. BDNF and Alcohol Addiction
    Dorit Ron; Fiscal Year: 2012
    ..Results generated from this study could lead to the identification of new targets for medication development to treat alcoholism and to the identification of genetic risk factors for the disease. ..
  20. Phenotypic and Functional Determination of Central Extended Amygdala Cell Groups
    HEIDI E DAY; Fiscal Year: 2010
    ..This in turn will be helpful in the design of treatment strategies for anxiety and fear-related disorders. ..
  21. DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCE
    Michael R Bruchas; Fiscal Year: 2013
    ....
  22. Cellular mechanisms underlying kappa opioid regulation of stress responses
    Julia C Lemos; Fiscal Year: 2010
    ..This line of research further elucidates the cellular mechanisms underlying maladaptive stress responses that make individuals vulnerable to disease. ..
  23. Dopaminergic Mechanisms of Kappa Opioid Receptor-Induced Potentiation of Cocaine
    Jonathan M Ehrich; Fiscal Year: 2012
    ....
  24. Development of Novel Opioid Peptides for Cocaine Abuse
    Jane V Aldrich; Fiscal Year: 2013
    ..Kappa opioid receptors (KOR) and their endogenous peptide agonists the dynorphins prominently modulate dopaminergic function...
  25. Kappa-opioid Receptor Modulation of the Stress Response
    Richard M Gustin; Fiscal Year: 2012
    ..Additionally, our wok has the potential to identify novel therapeutics that may reverse the affects of stress- induced depression and anxiety. ..
  26. NEW MODALITIES FOR TREATMENT OF PAIN AND DRUG ABUSE
    Victor J Hruby; Fiscal Year: 2013
    ..and tolerance;9)Determine changes occurring in the CNS which lead to enhanced spinal levels of non-opioid dynorphins which interact with the bradykinin receptor to produce hyperalgesia and mediate opioid withdrawal and contribute ..
  27. The Role of Dynorphin / Kappa-Opioid Systems in Alcohol Dependence
    Brendan M Walker; Fiscal Year: 2013
    ....
  28. Investigating the Neural Circuits of Itch
    SARAH ELIZABETH ROSS; Fiscal Year: 2013
    ....
  29. Electrophysiological Correlates of Vasopressin Secretion
    William Armstrong; Fiscal Year: 2009
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  30. Striatal 5-HT6 receptors, reward and addiction
    John F Neumaier; Fiscal Year: 2013
    ..The goal is to understand how serotonin participates in the adaptations associated with addiction so that we can design treatments to prevent or reverse these changes. ..
  31. Sex-dependent expression and utilization of spinal mu- and kappa-opioid systems
    NAIJIANG LIU; Fiscal Year: 2013
    ....
  32. Opioid and Noradrenergic Mechanisms in Stress and Drug Seeking
    Michael R Bruchas; Fiscal Year: 2013
    ..abstract_text> ..
  33. Neurobiology and Treatment of Pain
    SIDNEY S NEGUS; Fiscal Year: 2013
    ..We predict that pain will stimulate CREB phosphorylation and dynorphin synthesis in nucleus accumbens, and that these pain effects will be blocked by affective analgesics. ..
  34. NEURONAL SUBSTRATES OF COCAINE REWARD
    George F Koob; Fiscal Year: 2013
    ....
  35. SENSITIVE AND SELECTIVE DETECTION OF PEPTIDES
    Stephen G Weber; Fiscal Year: 2013
    ..activity is changed in order to support the neuroprotective functions of particular neuropeptides (galanin, dynorphins and enkephalins). However, the tools that can test this idea do not exist...
  36. Dynorphins and Kappa Opioid Receptors in the Stress Response
    Charles Chavkin; Fiscal Year: 2013
    ..In the next funding period, I expect to actively promote the professional development of two new tenure-track assistant professors (Zwiefel and Ong), 5 graduate students &3 postdoctoral fellows currently working in the lab. ..
  37. Imaging the Neurochemistry of Binge-Drinking in College-Aged Young Adults
    DIANA M MARTINEZ; Fiscal Year: 2013
    ..The goal of the present study is to investigate whether these alterations are present in young-adult binge drinkers, and to investigate potential mechanisms behind the disruptions in dopamine transmission. ..
  38. Peptidic Ligands for Kappa Opioid Receptors
    Jane V Aldrich; Fiscal Year: 2013
    ..Three specific aims will be pursued to accomplish these goals: 1) To explore the SAR of novel analogs of the dynorphins, the endogenous ligands for KOPr, 2) to explore the SAR of novel KOPr peptides that are structurally unrelated ..
  39. Ontogenetic changes in ethanol's motivational properties: Involvement of the kapp
    Michael E Nizhnikov; Fiscal Year: 2010
    ..Furthermore, these studies will investigate possible effect of early ethanol exposure on the motivational properties of ethanol and kappa opioid system. ..
  40. Role of Striatopallidal Neurons in Drug-Induced Neural Plasticity and Behavior
    Susan Marie Ferguson; Fiscal Year: 2010
    ..In so doing, this research may provide avenues for novel lines of therapeutic interventions in order to mitigate this serious public health issue. ..
  41. Peptidic Kappa Opioid Receptor Ligands as Potential Treatments for Drug Addiction
    Jane V Aldrich; Fiscal Year: 2011
    ..We expect that we will identify peptide KOR ligands that can be administered systemically to therapeutically prevent cocaine-seeking behavior. ..
  42. Buprenorphine for Depression and Anxiety
    Irwin Lucki; Fiscal Year: 2013
    ....
  43. Imaging the neurochemistry of negative reinforcement in cocaine abuse
    DIANA M MARTINEZ; Fiscal Year: 2013
    ..Using both imaging and behavioral studies, this application seeks to further our understanding this important phenomena in relapse. ..
  44. Translational Foundation of Adenosine Antagonist Use for Dyskinesias
    Michael A Schwarzschild; Fiscal Year: 2010
    ....
  45. Role of endogenous opioid peptides in opioid addiction
    LEON TSENG; Fiscal Year: 2005
    ..Attempt will be made to seek if there are correlative relationships among brain sites sensitive to opioids for the production of place preference or place aversion and the releases of opioid peptides and dopatnine. ..
  46. Kappa Opioid Receptor Activation Underlies Compulsive Methamphetamine Intake
    TIMOTHY WAYNE WHITFIELD; Fiscal Year: 2013
    ..b>Dynorphins produce dysphoric effects in animals and humans and have been hypothesized to mediate negative emotional states ..
  47. WIRELESS IN VIVO OPTICAL CONTROL OF STRESS NEURAL CIRCUITS AND GPCR SIGNALING
    Michael R Bruchas; Fiscal Year: 2013
    ....
  48. BETA-ENDORPHIN RECEPTOR AND DYNORPHIN RECEPTOR:
    Nancy Lee; Fiscal Year: 1993
    ....
  49. REGULATION OF N ARGININE DIBASIC CONVERTASE
    Eva Csuhai; Fiscal Year: 2000
    DESCRIPTION: (Applicant's Abstract) Opioid peptides are a family of endogenous peptides including dynorphins, enkephalins and endorphins. They cause naloxone-sensitive analgesic effects mediated through opiate receptors...
  50. Role of the 5-HT1A Receptors in Cocaine Dependence
    Sunmee Wee; Fiscal Year: 2013
    ..The outcome of the present proposal may provide further insight into mechanisms underlying the transition to drug addiction and may reveal new treatment opportunities. ..
  51. OPIOID PEPTIDES--RECEPTORS, BIOSYNTHESIS AND RELEASE
    HANS KOSTERLITZ; Fiscal Year: 1991
    ..The amount of released opioid varies between 18 to 30% of the tissue content...
  52. SPINAL RELEASE OF ENDORPHINS BY OPIOIDS
    LEON TSENG; Fiscal Year: 2002
    ..that are stimulated by endomorphins to cause antinociception and the release of biogenic amines, Met-enkephalin, dynorphins and other neurotransmitters for the spinal cord...
  53. Therapeutic Potential of Kappa Opioids
    Charles Chavkin; Fiscal Year: 2013
    ....
  54. OPIATE PEPTIDES AND RECEPTORS IN THE FAT/FAT MICE
    L Berman; Fiscal Year: 2002
    ..Dose response curves will be generated. These studies will provide information on opioid receptor types involved in feeding of fat/fat mice and development of obesity. ..
  55. ENDOGENOUS DYNORPHIN OPIOIDS AND TEMPORAL LOBE EPILEPSY
    Charles Chavkin; Fiscal Year: 1999
    ..The dynorphins are a family of inhibitory neuropeptides expressed at high concentration within the hippocampal formation...
  56. PET imaging of Naltrexone Occupancy of Kappa Receptors in Heavy Drinkers
    Evan D Morris; Fiscal Year: 2013
    ..The work will inform future studies into the KOR/dynorphin system and the search for pharmacotherapies for alcoholism. ..
  57. DYNORPHIN MODULATES CGRP RELEASE VIA PKC
    Zaijie Jim Wang; Fiscal Year: 2003
    ..Frank Porreca and Josephine Lai. This award is consistent with the long-term career goal of the candidate to become an independent investigator contributing to the basic research of pain and opioid pharmacology. ..
  58. LARGE SCALE SYNTHESIS OF THE OPIOID PEPTIDE DPDPE
    Richard Houghten; Fiscal Year: 1991
    ..Due to the high cost of the amino acid D-penicillamine (pen) and the disulfide bridge in the peptide, this synthesis will be an exacting test of the methods to be used during the proposed Phase I portion of this research...
  59. OPIATE RECEPTORS EEG SPECTRA TOLERANCE & DEPENDENCE
    Gerald Young; Fiscal Year: 1992
    ....
  60. ORPHANIN FQ (OFQ) EFFECTS ON RAT COLONIC MOTILITY
    Toku Takahashi; Fiscal Year: 2003
    ..This may have important clinical implications since OFQ or its analogues may be beneficial for the treatment of refractory constipation in humans. ..
  61. OPIATE DEPENDENCE AND TOLERANCE
    Richard Eisenberg; Fiscal Year: 1993
    ....
  62. CONTROL OF CATECHOLAMINE RELEASE BY ENDOGENOUS OPIATES
    WALTER DIXON; Fiscal Year: 1990
    ..A more complete understanding of the physiological roles of the various opiates will aid the treatment of mental illness...
  63. ENZYMES INVOLVED IN DYNORPHIN BIOSYNTHESIS
    Lakshmi Devi; Fiscal Year: 1993
    b>Dynorphins are a class of very potent opioid peptides with wide distribution in the central and peripheral nervous systems. Dynorphins may act both as neurotransmitters or neuromodulators in brain and as hormones in the endocrine system...
  64. Endogenous Opioid Mechanisms Modulating Stress
    JAY MCLAUGHLIN; Fiscal Year: 2006
    ..abstract_text> ..
  65. Analytical Methods for Investigating Peptide Transport
    SUSAN LUNTE; Fiscal Year: 2007
    ..The analytical methods developed in this proposal will also be of general utility to scientists involved in CNS research. ..
  66. SYNAPTIC ACTIONS OF OPIOID PEPTIDES IN THE HIPPOCAMPUS
    Roger Nicoll; Fiscal Year: 2001
    ....