caerulein

Summary

Summary: A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.

Top Publications

  1. pmc Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion
    Vijay P Singh
    Department of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA
    Gut 56:958-64. 2007
  2. ncbi Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
    Jan Nygaard Jensen
    Barbara Davis Center for Childhood Diabetes, U Colorado, HSC, 4200 E 9th Avenue, B140, Denver, Colorado 80262 USA
    Gastroenterology 128:728-41. 2005
  3. ncbi Disruption of paracellular sealing is an early event in acute caerulein-pancreatitis
    Marcus Schmitt
    Clinic for Gastroenterology, Hepatology, and Infectiology Universitätsklinikum Düsseldorf, Heinrich Heine Universität Düssseldorf, Germany
    Pancreas 28:181-90. 2004
  4. ncbi Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction
    Minoru Shigekawa
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Pathol 181:2105-13. 2012
  5. ncbi Hydrogen sulfide induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kappaB and Src-family kinases pathway
    Ramasamy Tamizhselvi
    Department of Pharmacology, National University of Singapore, Singapore, Singapore
    Exp Cell Res 316:1625-36. 2010
  6. pmc Induction of apoptosis by artemisinin relieving the severity of inflammation in caerulein-induced acute pancreatitis
    Ming Zhao
    Department of General Surgery, First Clinical College, Harbin Medical University, Harbin 150001, Heilongjiang Province, China
    World J Gastroenterol 13:5612-7. 2007
  7. ncbi Caerulein-and xenopsin-related peptides with insulin-releasing activities from skin secretions of the clawed frogs, Xenopus borealis and Xenopus amieti (Pipidae)
    Osama K Zahid
    Departmentof Chemistry, Faculty of Science, United Arab Emirates University, Al Ain, United Arab Emirates
    Gen Comp Endocrinol 172:314-20. 2011
  8. pmc Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells
    Daisuke Hashimoto
    Division of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    J Cell Biol 181:1065-72. 2008
  9. ncbi Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice
    Masaki Ohmuraya
    Division of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    Gastroenterology 129:696-705. 2005
  10. pmc Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice
    Han Bai
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Ward 6 118, Chicago, IL 60611, USA
    Carcinogenesis 32:1689-96. 2011

Research Grants

Detail Information

Publications234 found, 100 shown here

  1. pmc Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion
    Vijay P Singh
    Department of Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA
    Gut 56:958-64. 2007
    ..However, the mechanism by which it protects against pancreatitis still remains to be elucidated. Acute pancreatitis is associated with premature zymogen activation and a blockage in digestive enzyme secretion...
  2. ncbi Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration
    Jan Nygaard Jensen
    Barbara Davis Center for Childhood Diabetes, U Colorado, HSC, 4200 E 9th Avenue, B140, Denver, Colorado 80262 USA
    Gastroenterology 128:728-41. 2005
    ..To define cell differentiation changes associated with pancreatic regeneration in adult mice, we compared regeneration following caerulein-induced pancreatitis to that of normal pancreatic development.
  3. ncbi Disruption of paracellular sealing is an early event in acute caerulein-pancreatitis
    Marcus Schmitt
    Clinic for Gastroenterology, Hepatology, and Infectiology Universitätsklinikum Düsseldorf, Heinrich Heine Universität Düssseldorf, Germany
    Pancreas 28:181-90. 2004
    b>Caerulein-induced pancreatitis is a widely used experimental model for studies on acute pancreatitis, however, the molecular mechanisms underlying pancreatitis in response to caerulein hyperstimulation are incompletely understood...
  4. ncbi Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction
    Minoru Shigekawa
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Pathol 181:2105-13. 2012
    ..b>Caerulein administration activated pancreatic STAT3 and induced acute pancreatitis as early as 3 hours in wild-type mice, ..
  5. ncbi Hydrogen sulfide induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kappaB and Src-family kinases pathway
    Ramasamy Tamizhselvi
    Department of Pharmacology, National University of Singapore, Singapore, Singapore
    Exp Cell Res 316:1625-36. 2010
    ..In order to better understand this effect of H(2)S, acinar cells were stimulated with caerulein after addition of H(2)S donor, NaHS...
  6. pmc Induction of apoptosis by artemisinin relieving the severity of inflammation in caerulein-induced acute pancreatitis
    Ming Zhao
    Department of General Surgery, First Clinical College, Harbin Medical University, Harbin 150001, Heilongjiang Province, China
    World J Gastroenterol 13:5612-7. 2007
    ..To observe the apoptosis and oncosis of pancreatic acinar cells and secondary inflammatory reaction in pancreatic tissue from rats with acute pancreatitis (AP), and the influences of artemisinin on them...
  7. ncbi Caerulein-and xenopsin-related peptides with insulin-releasing activities from skin secretions of the clawed frogs, Xenopus borealis and Xenopus amieti (Pipidae)
    Osama K Zahid
    Departmentof Chemistry, Faculty of Science, United Arab Emirates University, Al Ain, United Arab Emirates
    Gen Comp Endocrinol 172:314-20. 2011
    b>Caerulein-related peptides were identified in norepinephrine-stimulated skin secretions of the tetraploid frog Xenopus borealis and the octoploid frog Xenopus amieti using negative ion electrospray mass spectrometry and their primary ..
  8. pmc Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells
    Daisuke Hashimoto
    Division of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860 0811, Japan
    J Cell Biol 181:1065-72. 2008
    ..These results suggest that autophagy exerts devastating effects in pancreatic acinar cells by activation of trypsinogen to trypsin in the early stage of acute pancreatitis through delivering trypsinogen to the lysosome...
  9. ncbi Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice
    Masaki Ohmuraya
    Division of Developmental Genetics, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
    Gastroenterology 129:696-705. 2005
    ..Point mutations in the SPINK1 gene seem to predispose humans to pancreatitis; however, the clinical significance of SPINK1 mutations remains controversial. This study aimed to elucidate the role of SPINK1...
  10. pmc Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice
    Han Bai
    Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Ward 6 118, Chicago, IL 60611, USA
    Carcinogenesis 32:1689-96. 2011
    ..on pancreatitis and pancreatic intraepithelial neoplasia (PanIN) was determined in a mutant Kras-driven and caerulein-induced pancreatitis-associated carcinogenesis in LSL-Kras(G12D)/Pdx1-Cre mice...
  11. ncbi A mouse model of severe acute pancreatitis induced with caerulein and lipopolysaccharide
    Shi Ping Ding
    Department of Lymphology, Department of Histology and Embryology, Medical College of Zhejiang University, Hangzhou 310031, Zhejiang Province, China
    World J Gastroenterol 9:584-9. 2003
    To establish a non-traumatic, easy to induce and reproducible mouse model of severe acute pancreatitis (SAP) induced with caerulein and lipopolyasccharide (LPS).
  12. ncbi Notch signaling is required for exocrine regeneration after acute pancreatitis
    Jens T Siveke
    Second Department of Internal Medicine, Klinikum rechts der Isar, Technical University of Munich, Munchen, Germany
    Gastroenterology 134:544-55. 2008
    ..To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling in cerulein-induced pancreatitis in mice...
  13. pmc Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats
    MADHAVI BHOOMAGOUD
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Gastroenterology 137:1083-92. 2009
    ..Clinical studies suggest that acidosis may affect the risk for developing pancreatitis. We hypothesized that exposure to an acid load might sensitize the acinar cell to secretagogue-induced pancreatitis...
  14. pmc Therapeutic effects of troglitazone in experimental chronic pancreatitis in mice
    David J van Westerloo
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Am J Pathol 166:721-8. 2005
    ..Thus, troglitazone attenuated pancreatic damage and inflammation in experimental chronic pancreatitis and remained beneficial in a therapeutic setting when given after initial damage had been established...
  15. ncbi Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis
    Akihiko Satoh
    Department of Gastroenterology, Division of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Pancreas 24:75-82. 2002
    ..Recent studies have shown that adenosine exerts potent anti-inflammatory properties that are chiefly brought about through the occupancy of the A2a receptor...
  16. ncbi Acetyl-L-carnitine ameliorates caerulein-induced acute pancreatitis in rats
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Cairo, Egypt
    Basic Clin Pharmacol Toxicol 105:30-6. 2009
    In the present study, we have addressed the possible protective role of acetyl-L-carnitine in caerulein-induced acute pancreatitis in male Swiss albino rats...
  17. ncbi Coordinate regulation of secretory stress proteins (PSP/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis
    R Graf
    Pancreatitis Research Laboratory, Department of Visceral and Transplant Surgery, University Hospital, 8091 Zurich, Switzerland
    J Surg Res 105:136-44. 2002
    ..Others reported that surgical manipulation of the pancreas, including sham controls, affected mRNA levels of PSP/reg. Neither report determined protein levels of PSP/reg...
  18. ncbi Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis
    Eriko Ohta
    Dept of Nephrology, Tokyo Medical and Dental Univ, Japan
    Am J Physiol Cell Physiol 297:C1368-78. 2009
    ..From these results, we conclude that AQP12 may function in the mechanisms that control the proper secretion of pancreatic fluid following rapid and intense stimulation...
  19. ncbi Histopathologic correlates of serum amylase activity in acute experimental pancreatitis
    J Schmidt
    Department of Surgery, Massachusetts General Hospital, Boston 02114
    Dig Dis Sci 37:1426-33. 1992
    ..31). Inasmuch as edema and fat necrosis are not important determinants of severity, these observations could explain the poor prognostic value of serum amylase activity in patients with acute pancreatitis...
  20. ncbi The combination of neurokinin-1 and galanin receptor antagonists ameliorates caerulein-induced acute pancreatitis in mice
    Savio G Barreto
    Department of General and Digestive Surgery, Flinders Medical Centre and Flinders University, Adelaide, South Australia, Australia
    Peptides 31:315-21. 2010
    ..Acute pancreatitis was induced in mice with 7-hourly caerulein injections...
  21. pmc Effects of S-propargyl-cysteine (SPRC) in caerulein-induced acute pancreatitis in mice
    Jenab N Sidhapuriwala
    Department of Pharmacology, National University of Singapore, Singapore, Singapore
    PLoS ONE 7:e32574. 2012
    ..AP was induced in mice by hourly caerulein injections (50 µg/kg) for 10 hours. Mice were treated with SPRC (10 mg/kg) or vehicle (distilled water)...
  22. ncbi Selective inhibition of NF-kappaB attenuates the severity of cerulein-induced acute pancreatitis
    Richard T Ethridge
    Departments of Surgery, The University of Texas Medical Branch, Galveston 77555 0533, USA
    J Am Coll Surg 195:497-505. 2002
    ..The purpose of this study was to determine whether the inhibition of NF-kappaB binding activity with a novel peptide that binds to the NF-kappaB essential modifier binding domain (NBD) could attenuate the severity of AP...
  23. ncbi The effect of interleukin-10 on acute pancreatitis induced by cerulein in a rat experimental model
    Mustafa Keceli
    Department of General Surgery, University of Erciyes, Kayseri, Turkey
    J Invest Surg 18:7-12. 2005
    ..Nevertheless, more experimental studies are needed to compare endogenous interleukin-10 with exogenous interleukin-10 effects before clinical usage of this drug...
  24. ncbi CEP-1347 inhibits caerulein-induced rat pancreatic JNK activation and ameliorates caerulein pancreatitis
    A C Wagner
    Department of Gastroenterology, University of Bern, CH 3010 Bern, Switzerland
    Am J Physiol Gastrointest Liver Physiol 278:G165-72. 2000
    Pancreatic caerulein-induced activation of c-Jun NH(2)-terminal kinase (JNK) has been reported, and JNK has been proposed as a mediator during induction of hyperstimulated pancreatitis...
  25. ncbi IGF-1 stimulates production of interleukin-10 and inhibits development of caerulein-induced pancreatitis
    Z Warzecha
    Department of Physiology, Jagiellonian University Medical School, Krakow, Poland
    J Physiol Pharmacol 54:575-90. 2003
    ..The aim of our studies was to determine the effect of IGF-1 administration on the development of caerulein-induced pancreatitis.
  26. ncbi COX-2 is not required for the development of murine chronic pancreatitis
    Alberto Silva
    Swiss HPB Center, Pancreatitis Research Laboratory, Department of Visceral and Transplantation Surgery, University Hospital, Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 300:G968-75. 2011
    ..Thus the pathophysiological roles of COX-2 and its therapeutic implications in patients with pancreatitis should be reexamined...
  27. pmc Cholinergic mediation of alcohol-induced experimental pancreatitis
    Aurelia Lugea
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Veterans Affairs Greater Los Angeles Healthcare System and University of California, Los Angeles, California 90073, USA
    Alcohol Clin Exp Res 34:1768-81. 2010
    ..For this study, we determined the role of the cholinergic system in ethanol-induced sensitizing effects on cerulein pancreatitis...
  28. pmc Hsp72 overexpression accelerates the recovery from caerulein-induced pancreatitis
    Mariia Lunova
    Department of Internal Medicine I, University Medical Center Ulm, Ulm, Germany
    PLoS ONE 7:e39972. 2012
    ..Increased Hsp72 levels were implicated in protection from acute pancreatitis; a hypothesis which was not tested in a transgenic mouse model yet...
  29. pmc Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats
    Mukaddes Esrefoglu
    Department of Histology and Embryology, Faculty of Medicine, Inonu Universitesi, 44280, Malatya, Turkey
    World J Gastroenterol 12:259-64. 2006
    ..the role of oxidative injury in pancreatitis-induced hepatic damage and the effect of antioxidant agents such as melatonin, ascorbic acid and N-acetyl cysteine on caerulein-induced pancreatitis and associated liver injury in rats.
  30. ncbi Down-regulation of tumor necrosis factor-associated factor 6 is associated with progression of acute pancreatitis complicating lung injury in mice
    Xiangyu Zhou
    Institute of Digestive Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, PR China
    Tohoku J Exp Med 217:279-85. 2009
    ..role of TRAF6 in the pathogenesis of AP and pancreatitis-associated acute lung injury using a mouse model of caerulein-induced AP (CAP)...
  31. ncbi Angiotensin II signaling through the AT1a and AT1b receptors does not have a role in the development of cerulein-induced chronic pancreatitis in the mouse
    Barbara Ulmasov
    Department of Internal Medicine, Saint Louis University School of Medicine, 3635 Vista Ave, St Louis, MO 63110, USA
    Am J Physiol Gastrointest Liver Physiol 299:G70-80. 2010
    ..Our results demonstrate that AT1a and AT1b receptor pathways do not seem to be essential for the development of pancreatitis in the mouse model of pancreatitis induced by repetitive cerulein injury...
  32. ncbi Caerulein precursor fragment (CPF) peptides from the skin secretions of Xenopus laevis and Silurana epitropicalis are potent insulin-releasing agents
    Dinesh Srinivasan
    School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine, N Ireland, BT52 1SA, UK
    Biochimie 95:429-35. 2013
    ..2 peptides), peptide glycine-leucine-amide (PGLa) (1 peptide), xenopsin precursor fragment (1 peptide), and caerulein precursor fragment (CPF) (6 peptides) families...
  33. ncbi The genes for the frog skin peptides GLa, xenopsin, levitide and caerulein contain a homologous export exon encoding a signal sequence and part of an amphiphilic peptide
    K Kuchler
    Institute of Molecular Biology, Austrian Academy of Sciences, Salzburg, Austria
    Eur J Biochem 179:281-5. 1989
    ..1987) Eur. J. Biochem. 169, 53-58] also contain a similar exon. This demonstrates the existence of a homologous export exon in genes encoding the precursors of different skin peptides...
  34. ncbi Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat
    J Jaworek
    Chair of Physiology, Jagiellonian University School of Medicine, Krakow, Poland
    J Physiol Pharmacol 53:791-804. 2002
    ..study investigated the involvement of endogenous melatonin in the prevention of pancreatic damage provoked by caerulein-induced pancreatitis (CIP) by using the luzindole, the antagonist of melatonin MT2 receptors...
  35. ncbi Melatonin reduces pancreatic prostaglandins production and protects against caerulein-induced pancreatitis in rats
    Han Ming Chen
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    J Pineal Res 40:34-9. 2006
    ..An acute pancreatitis model in male Sprague-Dawley rats (225-275 g) was established by continuously infusing caerulein (15 mg/kg/hr). Mean arterial pressure and pancreatic perfusion were monitored continuously...
  36. ncbi In vivo evidence for the role of GM-CSF as a mediator in acute pancreatitis-associated lung injury
    Jean Louis Frossard
    Department of Surgery, Beth Israel Hospital Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Lung Cell Mol Physiol 283:L541-8. 2002
    ..by hourly (12x) intraperitoneal injection of a supramaximally stimulating dose of the cholecystokinin analog caerulein. The resulting pancreatitis was similar in GM-CSF-sufficient (GM-CSF +/+) control animals and GM-CSF -/- mice...
  37. pmc Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo
    Bernd Baumann
    Institute of Physiological Chemistry, University of Ulm, Ulm, Germany
    J Clin Invest 117:1502-13. 2007
    ..Our data identify the IKK/NF-kappaB pathway in acinar cells as being key to the development of experimental pancreatitis and the major factor in the inflammatory response typical of this disease...
  38. ncbi Proteomic analysis of heat shock-induced protection in acute pancreatitis
    Vanessa Fetaud-Lapierre
    Department of Bioinformatics and Structural Biology, Geneva Faculty of Medicine, Geneva, Switzerland
    J Proteome Res 9:5929-42. 2010
    ..pancreatic proteins expression that were associated with thermal stress, both in healthy rats and in a model of caerulein-induced pancreatitis...
  39. ncbi The circadian rhythm of melatonin modulates the severity of caerulein-induced pancreatitis in the rat
    Jolanta Jaworek
    Department of Medical Physiology, Faculty of Health Care, Medical Faculty, Jagiellonian University CM, 31 531 Krakow, Poland
    J Pineal Res 37:161-70. 2004
    ..The aims of this study were: (a) to compare the severity of caerulein-induced pancreatitis (CIP) produced in the rat during the day and at the night, and (b) to assess the changes of ..
  40. ncbi Local disruption of the celiac ganglion inhibits substance P release and ameliorates caerulein-induced pancreatitis in rats
    Marc D Noble
    Department of Medicine, Duke University and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA
    Am J Physiol Gastrointest Liver Physiol 291:G128-34. 2006
    ..One week later, pancreatitis was induced by six hourly intraperitoneal injections of caerulein (50 microg/kg)...
  41. ncbi Inhibition of transforming growth factor beta signaling by halofuginone as a modality for pancreas fibrosis prevention
    Orit Zion
    Institute of Animal Sciences, The Volcani Center, Bet Dagan, Israel
    Pancreas 38:427-35. 2009
    ..Chronic pancreatitis is characterized by inflammation and fibrosis. We evaluated the efficacy of halofuginone, an inhibitor of collagen synthesis and myofibroblast activation, in preventing cerulein-induced pancreas fibrosis...
  42. ncbi Early induction of moderate hypothermia suppresses systemic inflammatory cytokines and intracellular adhesion molecule-1 in rats with caerulein-induced pancreatitis and endotoxemia
    Kenji Fujimoto
    Department of Critical Care and Emergency Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
    Pancreas 37:176-81. 2008
    ..To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats...
  43. ncbi Infliximab: a new therapeutic agent in acute pancreatitis?
    Nevin Oruc
    Ege University, Faculty of Medicine, Gastroenterology Department, Izmir, Turkey
    Pancreas 28:e1-8. 2004
    ..The aim of this study is to investigate the therapeutic effectiveness of monoclonal TNF antibody (infliximab) in acute edematous and severe necrotizing pancreatitis models in rats...
  44. pmc Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis
    Alyssa L Charrier
    Center for Clinical and Translational Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Lab Invest 90:1179-88. 2010
    ..PSC-derived CTGF is thus a candidate therapeutic target in anti-fibrotic strategies for ACP...
  45. ncbi PPAR-gamma knockout in pancreatic epithelial cells abolishes the inhibitory effect of rosiglitazone on caerulein-induced acute pancreatitis
    C Y Ivashchenko
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 293:G319-26. 2007
    ..To determine whether the effects of a TZD, rosiglitazone, on caerulein-induced acute pancreatitis are dependent on PPAR-gamma in the endodermal derivatives, we created a cell-type ..
  46. ncbi The role of pro-inflammatory molecules and pharmacological agents in acute pancreatitis and sepsis
    Muthu Kumaraswamy Shanmugam
    Cardiovascular Biology Research Programme, Department of Pharmacology, Center for Life Sciences, National University of Singapore, Yong Loo Lin School of Medicine, Singapore
    Inflamm Allergy Drug Targets 9:20-31. 2010
    ..Recently, the biochemical role of hydrogen sulfide (H(2)S) and substance P in caerulein induced AP and in cecal ligation and puncture induced sepsis and their role in the pathogenesis of the disease ..
  47. ncbi Adiponectin plays a protective role in caerulein-induced acute pancreatitis in mice fed a high-fat diet
    H Araki
    Department of Gastroenterology and Hepatology, Graduate School of Medicine, Osaka University, K1, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Gut 57:1431-40. 2008
    ..However, the role of adiponectin in AP has not been investigated...
  48. ncbi Novel antioxidant ameliorates the fibrosis and inflammation of cerulein-induced chronic pancreatitis in a mouse model
    Byung Moo Yoo
    Genome Research Center for Gastroenterology, Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea
    Pancreatology 5:165-76. 2005
    ..This study was aimed to establish the mice model of chronic fibrosing pancreatitis and to prove the involvement of OFRs in chronic pancreatitis with fibrosis...
  49. pmc Hedgehog signaling is required for effective regeneration of exocrine pancreas
    Volker Fendrich
    Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Gastroenterology 135:621-31. 2008
    ..Given the known role of Hh signaling in exocrine pancreatic cancer, these findings may provide a mechanistic link between injury-induced activation of pancreatic progenitors and subsequent pancreatic neoplasia...
  50. pmc A mouse model of ethanol dependent pancreatic fibrosis
    G Perides
    Department of Surgery, Tufts New England Medical Center, Boston, MA 02111, USA
    Gut 54:1461-7. 2005
    ..The majority of patients with chronic pancreatitis are alcoholics. Our goal was to develop a mouse model of alcohol dependent chronic pancreatitis...
  51. ncbi Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis
    Madhav Bhatia
    Department of Pharmacology and Cardiovascular Biology Research Group, National University of Singapore, Singapore
    J Cell Mol Med 12:580-90. 2008
    ..was aimed to investigate the interplay between pro-inflammatory effects of H(2)S and SP in a murine model of caerulein-induced acute pancreatitis...
  52. ncbi Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis
    Agnes S Kowalik
    Department of Physiology, The University of Western Ontario, London, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 292:G1123-32. 2007
    ..Following the induction of pancreatitis with caerulein, a CCK analog, we observed elevated serum amylase levels, necrosis, and tissue damage in Mist1 KO mice, ..
  53. ncbi Effect of hydrogen sulfide on the phosphatidylinositol 3-kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic acinar cells
    Ramasamy Tamizhselvi
    Department of Pharmacology, National University of Singapore, Singapore 117456
    J Pharmacol Exp Ther 329:1166-77. 2009
    ..To better understand the effect of H(2)S in inflammation, pancreatic acinar cells were stimulated with caerulein after the addition of NaHS (5, 10, and 30 microM)...
  54. ncbi Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F
    Maria Dolors Sans
    Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109 0622, USA
    Am J Physiol Gastrointest Liver Physiol 285:G517-28. 2003
    ..We therefore evaluated in C57BL/6 mice the effects of caerulein-induced AP on pancreatic protein synthesis, eIF2B activity and other protein translation regulatory mechanisms...
  55. ncbi Overexpression of Smad6 exacerbates pancreatic fibrosis in murine caerulein-induced chronic pancreatic injuries
    Tamao Miyamoto
    Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Pancreas 39:385-91. 2010
    ..We examined the effect of the overexpression of Smad6 on pancreatic fibrosis after chronic pancreatic injury...
  56. ncbi Curcumin ameliorates ethanol and nonethanol experimental pancreatitis
    Ilya Gukovsky
    Research Center for Alcoholic Liver and Pancreatic Diseases and Department of Medicine, University of California, Los Angeles and Veterans Affairs Greater Los Angeles Healthcare System, 90073, USA
    Am J Physiol Gastrointest Liver Physiol 284:G85-95. 2003
    ..They suggest that curcumin, which is currently in clinical trials for cancer prevention, may be useful for treatment of pancreatitis...
  57. ncbi Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats
    Lakshmi Bhagat
    Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 122:156-65. 2002
    ....
  58. pmc Both thermal and non-thermal stress protect against caerulein induced pancreatitis and prevent trypsinogen activation in the pancreas
    J L Frossard
    Division of Gastroenterology, Geneva University Hospitals, 1211 Geneva 14, Switzerland
    Gut 50:78-83. 2002
    ..Similarly, the effects of prior non-thermal stress on HSP70 expression and pancreatitis are not known. The current studies were designed to specifically address these issues...
  59. ncbi Recombinant human interleukin-11 decreases severity of acute necrotizing pancreatitis in mice
    T Shimizu
    Department of Gastroenterology, Tokyo Women s Medical University, School of Medicine, Japan
    Pancreas 21:134-40. 2000
    ....
  60. ncbi Protective effect of melatonin and its precursor L-tryptophan on acute pancreatitis induced by caerulein overstimulation or ischemia/reperfusion
    Jolanta Jaworek
    Jagiellonian University CM, Krakow, Poland
    J Pineal Res 34:40-52. 2003
    ..The aim of this study was to investigate the effects of melatonin and its precursor, l-tryptophan, on caerulein-induced pancreatitis (CIP) and on ischemia/reperfusion (I/R)-provoked pancreatitis in rats...
  61. ncbi Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator
    Baoan Ji
    Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Physiol Genomics 14:59-72. 2003
    ..to identify those genes commonly induced in rat pancreatic acinar cells within 1-4 h in two in vivo models, caerulein and taurocholate administration...
  62. ncbi Ultrastructural clues for the protective effect of ascorbic acid and N-acetylcysteine against oxidative damage on caerulein-induced pancreatitis
    Mukaddes Esrefoglu
    Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkey
    Pancreatology 6:477-85. 2006
    ..Oxygen free radicals (OFR) have been implicated in the induction of acute pancreatitis (AP)...
  63. pmc Experimental acute pancreatitis in PAP/HIP knock-out mice
    Meritxell Gironella
    INSERM, U 624, Marseille, France
    Gut 56:1091-7. 2007
    ..It was shown in vitro to be anti-apoptotic and anti-inflammatory. This study aims to look at whether PAP/HIP plays the same role in vivo...
  64. ncbi Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin
    Sohail Z Husain
    Dept of Pediatrics, 333 Cedar St, FMP408, PO Box 208064, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1594-9. 2007
    ..Isolated pancreatic acinar cells were stimulated with supraphysiological caerulein (100 nM) with or without the calcineurin inhibitors FK506 or cell-permeable calcineurin inhibitory peptide (CiP)...
  65. ncbi p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I
    Sophie Vasseur
    Centre de Recherche INSERM, EMI 0116, 163 Avenue de Luminy, BP172, 13009 Marseille, France
    J Biol Chem 279:7199-207. 2004
    ..In conclusion, p8 improves pancreatic resistance to inducers of acute pancreatitis by a mechanism implicating the expression of the anti-inflammatory protein PAP I...
  66. pmc Differences in platelet endothelial cell adhesion molecule-1 expression between peripheral circulation and pancreatic microcirculation in cerulein-induced acute edematous pancreatitis
    Hong Kai Gao
    Department of General Surgery, Division of Digestive Surgery and Organ Microcirculation, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 11:661-4. 2005
    ....
  67. pmc Effect of ligands that increase cAMP on caerulein-induced zymogen activation in pancreatic acini
    Z Lu
    GI Research Laboratory, Veterans Affairs Healthcare Connecticut, 950 Campbell Ave, West Haven, CT 06516, USA
    Am J Physiol Gastrointest Liver Physiol 285:G822-8. 2003
    ..Stimulation of acinar cells with supraphysiological concentrations of the CCK analog caerulein (CER) leads to protease activation and pancreatitis...
  68. ncbi Haemodynamic and exocrine effects of caerulein at submaximal and supramaximal levels on the rat pancreas: role of cholecystokinin receptor subtypes
    Thomas Griesbacher
    Institute for Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria
    Pancreatology 6:65-75; discussion 75-6. 2006
    We have investigated the involvement of cholecystokinin (CCK) receptor subtypes in haemodynamic changes in the pancreas of anaesthetized rats during submaximal and supramaximal stimulation with the CCK analogue, caerulein.
  69. ncbi Different effects of dexamethasone and the nitric oxide synthase inhibitor L-NAME on caerulein-induced rat acute pancreatitis, depending on the severity
    Yusuke Sugiyama
    Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii cho, Kamigyo, Kyoto, 802 8566, Japan
    Inflammopharmacology 13:291-301. 2005
    ..of dexamethasone and N(G)-nitro-L-arginine methyl ester (L-NAME), the nitric oxide (NO) synthase inhibitor, on caerulein-induced acute pancreatitis were examined in rats. Acute pancreatitis was induced by caerulein (20 mug/kg, s.c...
  70. pmc The ryanodine receptor mediates early zymogen activation in pancreatitis
    Sohail Z Husain
    Department of Pediatrics, Yale University School of Medicine and Veterans Affairs Connecticut Health Care, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:14386-91. 2005
    ..Inhibition of RYR also inhibited zymogen activation in vivo. We propose that Ca(2+) release from the RYR mediates zymogen activation but not enzyme secretion. The findings imply a role for the RYR in acute pancreatitis...
  71. ncbi Transgenic expression of pancreatic secretory trypsin inhibitor-I ameliorates secretagogue-induced pancreatitis in mice
    Jaimie D Nathan
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Gastroenterology 128:717-27. 2005
    ..In this study, we tested whether increased levels of pancreatic secretory trypsin inhibitor-I (PSTI-I) in mice could prevent secretagogue-induced pancreatitis...
  72. ncbi A rat model reproducing key pathological responses of alcoholic chronic pancreatitis
    Ilya Gukovsky
    UCLA VA Greater Los Angeles Healthcare System, West Los Angeles VA Healthcare Center, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 294:G68-79. 2008
    ..The results indicate that alcohol impairs recovery from acute pancreatitis, suggesting a mechanism by which alcohol sensitizes pancreas to chronic injury...
  73. pmc Alcohols enhance caerulein-induced zymogen activation in pancreatic acinar cells
    Zhao Lu
    Department of Internal Medicine, Section of Digestive Diseases, and Cell Biology, Veterans Administration Connecticut Healthcare, West Haven 06516, USA
    Am J Physiol Gastrointest Liver Physiol 282:G501-7. 2002
    ..The effects of the CCK analog, caerulein, and alcohol on trypsin and chymotrypsin activation in isolated pancreatic acini were examined...
  74. pmc Octreotide negates the benefit of galantide when used in the treatment of caerulein-induced acute pancreatitis in mice
    Savio G Barreto
    Department of General and Digestive Surgery, Flinders Medical Centre, Flinders University, Adelaide, SA, Australia
    HPB (Oxford) 12:403-11. 2010
    ..This study set out to compare the efficacy of a combined treatment of galantide and octreotide with the efficacy of each agent individually in experimental AP...
  75. pmc Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice
    Abrahim I Orabi
    Department of Pediatrics, 333 Cedar St, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 299:G196-204. 2010
    ..In this study, we examined whether pretreatment with the RYR inhibitor dantrolene attenuates the severity of caerulein-induced pancreatitis in mice...
  76. ncbi Treatment with H2S-releasing diclofenac protects mice against acute pancreatitis-associated lung injury
    Madhav Bhatia
    Department of Pharmacology and Cardiovascular Biology Research Group, National University of Singapore
    Shock 29:84-8. 2008
    ..These results suggest the usefulness of H(2)S-releasing nonsteroidal anti-inflammatory drugs as potential treatments for pancreatitis-associated lung injury...
  77. pmc Suppression of transforming growth factor beta signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations
    Stefan Wildi
    Department of Medicine and Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    Gut 56:685-92. 2007
    ..To determine whether endogenous TGF-betas modulate the course of caerulein induced acute pancreatitis, caerulein was administered to wild-type (FVB-/-) and transgenic mice that are ..
  78. ncbi The tripeptide analog feG ameliorates severity of acute pancreatitis in a caerulein mouse model
    Yusnita Rifai
    Dept of Surgery, Centre for Neuroscience, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia
    Am J Physiol Gastrointest Liver Physiol 294:G1094-9. 2008
    ..AP was induced in mice by hourly (x12) intraperitoneal injections of caerulein. A single dose of feG (100 microg/kg) was coadministered with caerulein either at time 0 h (prophylactic) or 3 h ..
  79. ncbi Leptin protects the pancreas from damage induced by caerulein overstimulation by modulating cytokine production
    Jolanta Jaworek
    Department of Physiology, Jagiellonian University Medical College, Cracow, Poland
    Pancreatology 2:89-99. 2002
    ..Recent identification of specific leptin receptors in the pancreas suggests that this peptide may also play some role in this gland...
  80. ncbi Lipid peroxidation inhibition reduces NF-kappaB activation and attenuates cerulein-induced pancreatitis
    Domenica Altavilla
    Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina Azienda Ospedaliera Universitario G Martino, Tore Biologica 5th Floor, Via Consolare Valeria, Gazzi, 98100 Messina, Italy
    Free Radic Res 37:425-35. 2003
    ..Indeed, lipid peroxidation inhibition might be considered a potential therapeutic approach to prevent the severe damage in acute pancreatitis...
  81. ncbi Role of macrophage inflammatory peptide-2 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injury
    Catherine M Pastor
    Division of Gastroenterology and Hepatology, Geneva University Hospital, Geneva, Switzerland
    Lab Invest 83:471-8. 2003
    ..These results show that MIP-2 plays a key role in the pathophysiology of acute pancreatitis and that MIP-2 blockade may improve the outcome of the disease...
  82. ncbi Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector
    J Jaworek
    Department of Med Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, 16 Grzegorzecka Street, Krakow, Poland
    J Physiol Pharmacol 58:65-80. 2007
    ..as well as its precursor; L-tryptophan, effectively protects the pancreas against the damage induced by caerulein overstimulation or ischemia/reperfusion...
  83. ncbi Increase of high-mobility group box chromosomal protein 1 in blood and injured organs in experimental severe acute pancreatitis
    Takeo Yasuda
    Pancreas 34:487-8. 2007
  84. pmc Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis
    Fatma Ayca Gultekin
    Gazi University, School of Medicine, Department of General Surgery, Besevler 06510 Ankara, Turkey
    World J Gastroenterol 13:2932-8. 2007
    ..To determine the effect of exogenous leptin on acute lung injury (ALI) in cerulein-induced acute pancreatitis (AP)...
  85. ncbi VIP attenuation of the severity of experimental pancreatitis is due to VPAC1 receptor-mediated inhibition of cytokine production
    Mizuho Kojima
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pancreas 30:62-70. 2005
    ..Therefore, we investigated the effects of VIP and selective agonists for 2 subtypes of VIP receptor (VPAC1-R and VPAC2-R agonist) on acute pancreatitis...
  86. ncbi Influence of ischemic preconditioning on blood coagulation, fibrinolytic activity and pancreatic repair in the course of caerulein-induced acute pancreatitis in rats
    Z Warzecha
    Department of Physiology, Jagiellonian University Medical College, Krakow, Poland
    J Physiol Pharmacol 58:303-19. 2007
    ..The aim of the investigation was to determine whether ischemic preconditioning affects the course edematous pancreatitis...
  87. ncbi An improved method for extracting myeloperoxidase and determining its activity in the pancreas and lungs during pancreatitis
    Rajinder Dawra
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Pancreas 37:62-8. 2008
    ....
  88. ncbi Adrenomedullin reduces the severity of cerulein-induced acute pancreatitis
    Ozge Ecmel Onur
    Department of Emergency Medicine, Marmara University School of Medicine, Istanbul, Turkey
    Peptides 28:2179-83. 2007
    ..These could be due to anti-inflammatory properties of AM, inhibition of proinflammatory cytokine secretion, reducing the endothelial permeability increased by reactive oxygen species, endotoxins or cytokines...
  89. ncbi Possible involvement of endogenous 5-HT in aggravation of cerulein-induced acute pancreatitis in mice
    Kentaro Hamada
    UMN Pharma, Inc, Department of Pharmacology, 1 15 8 Jinnan, Shibuya ku Tokyo 150 0041, Japan
    J Pharmacol Sci 105:240-50. 2007
    ..These results suggest that endogenously released 5-HT activates 5-HT2A receptors to aggravate cerulein-induced pancreatitis. We propose that selective 5-HT2A antagonists may provide a new therapy for acute pancreatitis...
  90. ncbi A murine model of obesity implicates the adipokine milieu in the pathogenesis of severe acute pancreatitis
    Nicholas J Zyromski
    Department of Surgery, Indiana University School of Medicine, 535 Barnhill Dr, RT 130, Indianapolis, IN 46202, USA
    Am J Physiol Gastrointest Liver Physiol 295:G552-8. 2008
    ..These data demonstrate that congenitally obese mice develop more severe AP than lean animals when challenged by cerulein hyperstimulation and suggest that alteration of the adipokine milieu exacerbates the severity of AP in obesity...
  91. ncbi Effects of R-102444 and its active metabolite R-96544, selective 5-HT2A receptor antagonists, on experimental acute and chronic pancreatitis: Additional evidence for possible involvement of 5-HT2A receptors in the development of experimental pancreatitis
    Taketoshi Ogawa
    Pharmacology and Molecular Biology Research Laboratories, Sankyo Co, Ltd, 1 2 58 Hiromachi, Tokyo 140 8710, Japan
    Eur J Pharmacol 521:156-63. 2005
    ..Rat acute pancreatitis was induced by caerulein (20 microg/kg) intraperitoneal injection and by pancreatic duct ligation...
  92. ncbi Endotoxemia in newborn rats attenuates acute pancreatitis at adult age
    J Jaworek
    Dept of Medical Physiology Faculty of Health Care, Medical Faculty Jagiellonian University School of Medicine, Cracow, Poland
    J Physiol Pharmacol 58:131-47. 2007
    ..Two months later these rats have been subjected to i.p. cearulein infusion (25 microg/kg) to produce caerulein-induced pancreatitis (CIP)...
  93. ncbi Does the septic shock interfere experimental acute pancreatitis in rats?
    S Hac
    Department of General Endocrine and Transplant Surgery, Medical University of Gdansk, 7 Debinki Street, 80 952 Gdansk, Poland
    Med Chem 2:423-9. 2006
    ..Two complex and multifactorial pathogenetic ways lead to edematous or necrotizing pancreatitis. The course of the disease is thought to be the consequence of an acute inflammatory response...
  94. ncbi Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitis
    Gijs J D Van Acker
    Dept of Surgery, Tufts New England Medical Center, 860 Washington St, Boston, MA 02111, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1738-46. 2007
    ..pancreatitis events, we induced pancreatitis in mice by repeated supramaximal secretagogue stimulation with caerulein. Some animals were pretreated with the cathepsin B inhibitor CA-074 me to inhibit cathepsin B, prevent ..
  95. ncbi Pancreatic and bile duct obstruction exacerbates rat caerulein-induced pancreatitis: a new experimental model of acute hemorrhagic pancreatitis
    Mitsuo Yamasaki
    Department of Surgery, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka sayama 595 8511, Japan
    J Gastroenterol 41:352-60. 2006
    ..The aim of the present study was to test the hypothesis that pancreatic and bile duct obstruction exacerbates edematous pancreatitis induced by supramaximal secretory stimulation by caerulein.
  96. pmc Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen
    Lena Selig
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Leipzig, Germany
    BMC Gastroenterol 6:30. 2006
    ..The R122H mutation of the cationic trypsinogen was found in patients with hereditary pancreatitis. A transgenic animal carrying this mutation could be useful as a genetic model system of pancreatitis...
  97. pmc Hyperlipidemia intensifies cerulein-induced acute pancreatitis associated with activation of protein kinase C in rats
    Ya Jun Wang
    Department of General Surgery, Xuanwu Hospital of Capital University of Medical Sciences, 45 Changchun Street, Beijing 100053, China
    World J Gastroenterol 12:2908-13. 2006
    ..To investigate the effects of hyperlipidemia on acute pancreatitis (AP) and the possible mechanisms...
  98. ncbi Early bacterial infection of the pancreas and course of disease in cerulein-induced acute pancreatitis in rats
    G Manes
    Department of Gastroenterology, Otto von Guericke University Magdeburg, Germany
    Dig Liver Dis 38:423-8. 2006
    ..Since bacterial translocation from the gut is likely to be an early event, in an animal model of pancreatitis, we investigated the effect of early bacterial supra-infection of the pancreas on the course of the disease...
  99. ncbi The STAT4 and STAT6 pathways in pancreatitis-associated lung injury
    Misho O Simovic
    Department of Surgery, Meharry Medical College, Nashville, Tennessee, USA
    J Surg Res 137:10-5. 2007
    ..We examined the roles of STAT4 and STAT6 in lung injury after caerulein-induced severe acute pancreatitis...
  100. pmc Neutrophil depletion--but not prevention of Kupffer cell activation--decreases the severity of cerulein-induced acute pancreatitis
    Catherine M Pastor
    Laboratoire de Physiopathologie Hépatique et Imagerie Moléculaire, Hopitaux Universitaires de Geneve, 24 Rue Micheli du Crest, 1205 Geneva, Switzerland
    World J Gastroenterol 12:1219-24. 2006
    ..To determine whether neutrophil depletion and Kupffer cell inhibition might combine their protective effects to decrease the severity of acute pancreatitis...
  101. ncbi Evaluation of two novel peptide safety markers for exocrine pancreatic toxicity
    Jennie L Walgren
    Pfizer Global Research and Development, Drug Safety Research and Development, Chesterfield, Missouri 63017, USA
    Toxicol Sci 96:184-93. 2007
    ..in different species, we measured RA1609 and RT2864 marker levels in rats treated with the pancreatic toxicant caerulein, and in mice treated with CHB...

Research Grants24

  1. Plasminogen System and Alcoholic Pancreatitis
    Aurelia Lugea; Fiscal Year: 2007
    ..Therapeutic strategies focusing on the regulation of plg activation may be central in preventing or reverting alcohol-induced pancreas fibrosis. [unreadable] [unreadable] [unreadable]..
  2. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..The PI has demonstrated that TRPV1 is activated in several models of pancreatitis including caerulein-induced pancreatitis and has extensive pharmacological data indicating that TRPV1 inhibition reduces the ..
  3. Dietary Regulation of Pancreatic Digestive Enzymes
    John A Williams; Fiscal Year: 2013
    ..We will study regeneration following two models of pancreatitis induced by ethionine and caerulein over-stimulation...
  4. Characterization of lcmt in Animal Models of Cancer
    MARK REID PHILIPS; Fiscal Year: 2013
    ..effect of pancreatic ductal epithelial cells (PDECs), and we will determine the effect of Icmt deficiency on caerulein-induced pancreatic inflammation. Aim 2: Effect of Icmt deficiency on alternate mouse models of neoplasia...
  5. HEAT SHOCK PROTEINS AND PANCREATITIS
    Ashok K Saluja; Fiscal Year: 2013
    ..for the first time in pancreatic acinar cells that HSP70 attenuates cytosolic calcium elevation in response to caerulein stimulation...
  6. PHOSPHOLIPID TURNOVER IN EXOCRINE PANCREAS
    Ronald Rubin; Fiscal Year: 1991
    ..which directly activate protein kinase C, to interact synergistically with activators of PLA2 (ionomycin, caerulein, carbachol) with regard to enhancing cellular [Ca2+], arachidonic acid metabolism, protein phosphorylation, and ..
  7. Inhibition of pancreatic carcinogenesis via targeting c-Raf and sEH
    Guang Yu Yang; Fiscal Year: 2013
    ..In mutant Kras-initiated pancreatic tumorigenesis in Pdx1-Cre/LSL-KrasG12D mice (called PanKras), caerulein- induced pancreatitis enhances malignant progression...
  8. Initiation of the Sterile Inflammatory Response in Acute Pancreatitis
    Rafaz Hoque; Fiscal Year: 2013
    ..Our preliminary data demonstrate that in caerulein-induced acute pancreatitis: i...
  9. ALTERED ACINAR CELL FUNCTION DURING ACUTE PANCREATITIS
    Robert Powers; Fiscal Year: 1992
    The in vivo administration of the cholecystokinin analogue, caerulein (CER) in excess of the concentration required to induce maximal secretion (hyperstimulation) leads to the rapid formation of acute pancreatitis in mice as defined by ..
  10. Pathophysiology of Arginine-induced Pancreatitis in Mice
    Ashok Saluja; Fiscal Year: 2006
    ..maintenance, in fact, the most commonly used investigative model in experimental pancreatitis is that induced by caerulein in mice. However, caerulein only induces relatively mild form of the disease...
  11. A model of obesity-associated severe acute pancreatitis
    Giamila Fantuzzi; Fiscal Year: 2007
    ..The novel model will also be compared with the well-established model of AP induced by administration of caerulein. This exploratory project will verify whether a novel, pathologically relevant model of severe AP can be used as ..
  12. Molecular mechanisms of pancreatic fibrogenesis
    Brent Neuschwander Tetri; Fiscal Year: 2007
    ..Accomplishing these aims will fill significant gaps in the understanding of chronic pancreatitis and this new knowledge may help identify effective treatment approaches to this disease. [unreadable] [unreadable]..
  13. TRANSGENIC MOUSE MODELS OF PANCREATIC EXOCRINE FUNCTION
    ROBERT DE LISLE; Fiscal Year: 2003
    ..That over expresses Muclin in the pancreatic acinar cell using the rat elastase promoter to direct cell specific expression. ..
  14. PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEM
    ROBERT DE LISLE; Fiscal Year: 2003
    ..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
  15. NADPH oxidase and pancreatic cancer cell survival
    Anna Gukovskaya; Fiscal Year: 2009
    ....
  16. Ryanodine Receptor and Pancreatic Zymogen Activation
    Sohail Husain; Fiscal Year: 2008
    ..In addition, the candidate will be mentored by individuals with particular expertise in pancreatitis and acinar Ca2+ signaling, and both mentors have extensive experience training fellows as well. ..
  17. Urokinase-type Plasminogen Activator System and Pancreatic Stellate Cells
    Aurelia Lugea; Fiscal Year: 2007
    ..Therapeutic strategies focusing on the regulation of uPA activation may be central in preventing or reverting alcohol-induced pancreas fibrosis. [unreadable] [unreadable] [unreadable]..
  18. Murine Model for Alcohol Dependent Chronic Pancreatitis
    George Perides; Fiscal Year: 2006
    ..abstract_text> ..
  19. Protection of Steatotic Livers From Primary Nonfunction
    Kenneth D Chavin; Fiscal Year: 2010
    ..3) Using isolated hepatocytes, determine the mechanism(s) by which UCP2 increases the sensitivity of steatotic hepatocytes to necrotic cell death and mitochondrial dysfunction following hypoxia/reoxygenation (H/R) injury. ..
  20. Role of CCK Receptor in Acute Pancreatitis Pathogenesis
    Isaac Samuel; Fiscal Year: 2007
    ..James W. Maher, MD, Director, Division of Gastrointestinal Surgery, University of Iowa College of Medicine, Iowa City. [] PHS 398/2590 (Rev. 05/01) Page__ 26 Continuation Format Page [] ..
  21. Pancreatic zymogen activation in a reconstituted system
    Edwin Thrower; Fiscal Year: 2006
    ..First, using a caerulein-hyperstimulation model of acute pancreatitis, we find that activated zymogens are found in both zymogen granule ..
  22. The Role of COX-2 and PPAR-Gamma in Pancreatic Cancer
    Guido Eibl; Fiscal Year: 2007
    ..abstract_text> ..