oligopeptides

Summary

Summary: Peptides composed of between two and twelve amino acids.

Top Publications

  1. ncbi Telaprevir for previously untreated chronic hepatitis C virus infection
    Ira M Jacobson
    Weill Cornell Medical College and Center for the Study of Hepatitis C, New York, NY 10021, USA
    N Engl J Med 364:2405-16. 2011
  2. ncbi Telaprevir for retreatment of HCV infection
    Stefan Zeuzem
    Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany
    N Engl J Med 364:2417-28. 2011
  3. pmc Response-guided telaprevir combination treatment for hepatitis C virus infection
    Kenneth E Sherman
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0595, USA
    N Engl J Med 365:1014-24. 2011
  4. ncbi Telaprevir for previously treated chronic HCV infection
    John G McHutchison
    Duke Clinical Research Institute and Duke University Medical Center, Durham, NC, USA
    N Engl J Med 362:1292-303. 2010
  5. ncbi Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan
    Hiromitsu Kumada
    Department of Hepatology, Toranomon Hospital, Tokyo, Japan
    J Hepatol 56:78-84. 2012
  6. pmc Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
    Sophie Messager
    Paradigm Therapeutics, 214 Cambridge Science Park, Milton Road, Cambridge CB4 0WA, United Kingdom
    Proc Natl Acad Sci U S A 102:1761-6. 2005
  7. ncbi Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients
    Tara L Kieffer
    Vertex Pharmaceuticals Inc, Cambridge, MA 02139, USA
    Hepatology 46:631-9. 2007
  8. ncbi Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
    Christoph Sarrazin
    Klinik fur Innere Medizin II, Universitat des Saarlandes, Homburg Saar, Germany
    Gastroenterology 132:1767-77. 2007
  9. ncbi Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
    Simone Susser
    JW Goethe University Hospital, Frankfurt, Germany
    Hepatology 50:1709-18. 2009
  10. ncbi RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
    Ulrich Hersel
    Institut fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstr 4, D 85747, Garching, Germany
    Biomaterials 24:4385-415. 2003

Detail Information

Publications305 found, 100 shown here

  1. ncbi Telaprevir for previously untreated chronic hepatitis C virus infection
    Ira M Jacobson
    Weill Cornell Medical College and Center for the Study of Hepatitis C, New York, NY 10021, USA
    N Engl J Med 364:2405-16. 2011
    ....
  2. ncbi Telaprevir for retreatment of HCV infection
    Stefan Zeuzem
    Johann Wolfgang Goethe University Medical Center, Frankfurt am Main, Germany
    N Engl J Med 364:2417-28. 2011
    ..Up to 60% of patients with hepatitis C virus (HCV) genotype 1 infection do not have a sustained virologic response to therapy with peginterferon alfa plus ribavirin...
  3. pmc Response-guided telaprevir combination treatment for hepatitis C virus infection
    Kenneth E Sherman
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0595, USA
    N Engl J Med 365:1014-24. 2011
    ..We designed a noninferiority trial (noninferiority margin, -10.5%) to compare rates of sustained virologic response among patients receiving two treatment durations...
  4. ncbi Telaprevir for previously treated chronic HCV infection
    John G McHutchison
    Duke Clinical Research Institute and Duke University Medical Center, Durham, NC, USA
    N Engl J Med 362:1292-303. 2010
    ..Patients with genotype 1 hepatitis C virus (HCV) who do not have a sustained response to therapy with peginterferon alfa and ribavirin have a low likelihood of success with retreatment...
  5. ncbi Telaprevir with peginterferon and ribavirin for treatment-naive patients chronically infected with HCV of genotype 1 in Japan
    Hiromitsu Kumada
    Department of Hepatology, Toranomon Hospital, Tokyo, Japan
    J Hepatol 56:78-84. 2012
    ..To evaluate the efficacy and safety of telaprevir in combination with peginterferon-α2b (PEG-IFN) and ribavirin (RBV) in patients with chronic hepatitis C...
  6. pmc Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
    Sophie Messager
    Paradigm Therapeutics, 214 Cambridge Science Park, Milton Road, Cambridge CB4 0WA, United Kingdom
    Proc Natl Acad Sci U S A 102:1761-6. 2005
    ..The localization and GnRH release effects of kisspeptin thus define GPR54 as a major control point in the reproductive axis and suggest kisspeptin to be a neurohormonal effector...
  7. ncbi Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients
    Tara L Kieffer
    Vertex Pharmaceuticals Inc, Cambridge, MA 02139, USA
    Hepatology 46:631-9. 2007
    ....
  8. ncbi Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
    Christoph Sarrazin
    Klinik fur Innere Medizin II, Universitat des Saarlandes, Homburg Saar, Germany
    Gastroenterology 132:1767-77. 2007
    ..4A protease inhibitor, has shown strong antiviral activity in phase 1 clinical studies. Because of high levels of HCV replication and the low fidelity of HCV polymerase, selection of resistant isolates during therapy may occur...
  9. ncbi Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
    Simone Susser
    JW Goethe University Hospital, Frankfurt, Germany
    Hepatology 50:1709-18. 2009
    ..Mathematical modeling revealed impaired replicative fitness for all single mutations, whereas for combined mutations a relative increase of replication efficiency was suggested...
  10. ncbi RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
    Ulrich Hersel
    Institut fur Organische Chemie und Biochemie, Technische Universitat Munchen, Lichtenbergstr 4, D 85747, Garching, Germany
    Biomaterials 24:4385-415. 2003
    ..The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed...
  11. ncbi Cyanobacterial peptides - nature's own combinatorial biosynthesis
    Martin Welker
    Technische Universitat Berlin, Institut fur Chemie, AG Biochemie, Berlin, Germany
    FEMS Microbiol Rev 30:530-63. 2006
    ..Among the known structures, oligopeptides are often found with many congeners sharing conserved substructures, while being highly variable in others...
  12. ncbi Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand
    Jian Ping Xiong
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Science 296:151-5. 2002
    ..Ligand binding induces small changes in the orientation of alphaV relative to beta3...
  13. pmc A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myeloma
    David S Siegel
    John Theurer Cancer Center at Hackensack University, Hackensack, NJ 07601, USA
    Blood 120:2817-25. 2012
    ..This trial was registered at www.clinicaltrials.gov as #NCT00511238...
  14. ncbi A receptor in pituitary and hypothalamus that functions in growth hormone release
    A D Howard
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Science 273:974-7. 1996
    ..On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone...
  15. ncbi Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
    John G McHutchison
    Duke Clinical Research Institute and Duke University, Durham, NC 27715, USA
    N Engl J Med 360:1827-38. 2009
    ..Telaprevir, a protease inhibitor specific to the HCV nonstructural 3/4A serine protease, rapidly reduced HCV RNA levels in early studies...
  16. pmc Phenotypic characterization of resistant Val36 variants of hepatitis C virus NS3-4A serine protease
    Yi Zhou
    Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139, USA
    Antimicrob Agents Chemother 52:110-20. 2008
    ..Finally, the sensitivity of these replicon variants to alpha interferon or ribavirin remained unchanged compared to that of the wild-type...
  17. pmc An open-label, single-arm, phase 2 (PX-171-004) study of single-agent carfilzomib in bortezomib-naive patients with relapsed and/or refractory multiple myeloma
    Ravi Vij
    Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 119:5661-70. 2012
    ..1% overall (1 grade 3; no grade 4)-in these pretreated bortezomib-naive patients. The results of the present study support the use of carfilzomib in R/R MM patients. This trial is registered at www.clinicaltrials.gov as NCT00530816...
  18. pmc Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster
    Gyunghee Lee
    Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, USA
    Genetics 167:311-23. 2004
    ..From these findings, we propose another role for AKH in the regulation of starvation-induced foraging behavior...
  19. pmc Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients
    Thomas Kuntzen
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Hepatology 48:1769-78. 2008
    ..Viral loads were high in the majority of these patients, suggesting that drug-resistant viral strains might achieve replication levels comparable to nonresistant viruses in vivo...
  20. pmc TDIF peptide signaling regulates vascular stem cell proliferation via the WOX4 homeobox gene in Arabidopsis
    Yuki Hirakawa
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Plant Cell 22:2618-29. 2010
    ..Detailed observations in loss-of-function mutants revealed that TDIF-TDR-WOX4 signaling plays a crucial role in the maintenance of the vascular meristem organization during secondary growth...
  21. ncbi Substrate specificities of caspase family proteases
    R V Talanian
    BASF Bioresearch Corp, Worcester, Massachusetts 01605, USA
    J Biol Chem 272:9677-82. 1997
    ..The results also suggest the design of optimal peptidic substrates and inhibitors...
  22. ncbi (68)Ga-labeled multimeric RGD peptides for microPET imaging of integrin alpha(v)beta (3) expression
    Zi Bo Li
    Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305 5484, USA
    Eur J Nucl Med Mol Imaging 35:1100-8. 2008
    ..The goal of this study was to investigate the feasibility of (68)Ga-labeled RGD peptides for tumor imaging...
  23. pmc Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates
    Muhammad Shahab
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:2129-34. 2005
    ....
  24. pmc Molecular cloning of a potential proteinase activated receptor
    S Nystedt
    Division of Molecular Neurobiology, Wallenberg Laboratory, Lund University, Sweden
    Proc Natl Acad Sci U S A 91:9208-12. 1994
    ..Because this, to our knowledge, is the second example, besides the thrombin receptor, of a proteolytically activated seven-transmembrane G-protein-coupled receptor, we have provisionally named it proteinase activated receptor 2...
  25. ncbi Pyoverdine siderophores: from biogenesis to biosignificance
    Paolo Visca
    Department of Biology, University Roma Tre, Rome I 00146, Italy
    Trends Microbiol 15:22-30. 2007
    ..Pyoverdine-dependent iron transport is also crucial for biofilm development, further expanding the importance of these siderophores in Pseudomonas biology...
  26. pmc Tissue-penetrating delivery of compounds and nanoparticles into tumors
    Kazuki N Sugahara
    Vascular Mapping Center, Burnham Institute for Medical Research at UCSB, Biology II Building, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Cancer Cell 16:510-20. 2009
    ..Conjugation to iRGD significantly improved the sensitivity of tumor-imaging agents and enhanced the activity of an antitumor drug...
  27. ncbi Once-daily atazanavir/ritonavir versus twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 48 week efficacy and safety results of the CASTLE study
    Jean Michel Molina
    Department of Infectious Diseases, Saint Louis Hospital, AP HP, Paris University of Paris Diderot, Paris 7, France
    Lancet 372:646-55. 2008
    ..We compared these two combinations directly in treatment-naive patients...
  28. ncbi Ag85B-ESAT-6 adjuvanted with IC31® promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in volunteers with previous BCG vaccination or tuberculosis infection
    Jaap T van Dissel
    Leiden University Medical Center LUMC, Department of Infectious Diseases, Leiden, The Netherlands j t van
    Vaccine 29:2100-9. 2011
    ..The strong responses persisted through 32 weeks of follow-up, indicating the induction of a persistent memory response in the vaccine recipients...
  29. ncbi Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis
    R Pasqualini
    The Burnham Institute, La Jolla, California 92037, USA
    Cancer Res 60:722-7. 2000
    ..Thus, APN is involved in angiogenesis and can serve as a target for delivering drugs into tumors and for inhibiting angiogenesis...
  30. ncbi Discovery and development of telaprevir: an NS3-4A protease inhibitor for treating genotype 1 chronic hepatitis C virus
    Ann D Kwong
    Vertex Pharmaceuticals, Cambridge, Massachusetts, USA
    Nat Biotechnol 29:993-1003. 2011
    ..Lessons learned from the development of telaprevir suggest that makers of innovative medicines cannot rely solely on traditional drug discovery metrics, but must develop innovative, scientifically guided pathways for success...
  31. pmc Integrins
    Malgorzata Barczyk
    Department of Biomedicine, University of Bergen, Norway
    Cell Tissue Res 339:269-80. 2010
    ..The current review summarizes some basic facts about the integrin family including a historical perspective, their structure, and their ligand-binding properties...
  32. pmc Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells
    Hiroyuki Tada
    Department of Microbiology and Immunology, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Infect Immun 73:7967-76. 2005
    ..These findings suggest that Nod1 and Nod2 agonists in combination with TLR3, TLR4, and TLR9 agonists synergistically induce IL-12 and IFN-gamma production in DCs to induce Th1-lineage immune responses...
  33. ncbi Treatment modification in human immunodeficiency virus-infected individuals starting combination antiretroviral therapy between 2005 and 2008
    Luigia Elzi
    University Hospital Basel, Switzerland
    Arch Intern Med 170:57-65. 2010
    ..Adverse effects of combination antiretroviral therapy (CART) commonly result in treatment modification and poor adherence...
  34. ncbi Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin
    Norio Akuta
    Department of Hepatology, Toranomon Hospital, Tokyo, Japan
    Hepatology 52:421-9. 2010
    ..In the patients having genotype non-TT, those of Arg70 gained high sustained virological response (50%), and sustained virological response (12%) was the worst in patients who possessed both genotype non-TT and Gln70(His70)...
  35. ncbi Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    Christophe Hezode
    Assistance Publique Hopitaux de Paris, Henri Mondor Hospital, University of Paris 12 and INSERM Unité 955, Creteil, France
    N Engl J Med 360:1839-50. 2009
    ..Telaprevir is a specific inhibitor of the HCV serine protease and could be of value in HCV treatment...
  36. ncbi An open-label, single-arm, phase 2 study of single-agent carfilzomib in patients with relapsed and/or refractory multiple myeloma who have been previously treated with bortezomib
    Ravi Vij
    Washington University School of Medicine, St Louis, MO 63110, USA
    Br J Haematol 158:739-48. 2012
    ....
  37. pmc Cyclic RGD peptide-modified liposomal drug delivery system: enhanced cellular uptake in vitro and improved pharmacokinetics in rats
    Zhongya Chen
    National Pharmaceutical Engineering Research Center, Shanghai, People s Republic of China
    Int J Nanomedicine 7:3803-11. 2012
    ..Thus, coupling the RGD motif to the liposomal surface for achieving active targeting can be a promising strategy for the treatment of tumors...
  38. ncbi Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events
    Shirin Arastu-Kapur
    Onyx Pharmaceuticals, Inc South San Francisco, California 94080, USA
    Clin Cancer Res 17:2734-43. 2011
    ..Carfilzomib, a tetrapeptide epoxyketone proteasome inhibitor, currently in clinical investigation in myeloma, is associated with low rates of PN. We sought to determine whether PN represents a target-mediated adverse drug reaction (ADR)...
  39. pmc Siderophore-mediated signaling regulates virulence factor production in Pseudomonasaeruginosa
    Iain L Lamont
    Department of Biochemistry and Centre for Gene Research, University of Otago, P O Box 56, Dunedin, New Zealand
    Proc Natl Acad Sci U S A 99:7072-7. 2002
    ..Recognition that a siderophore acts as a signaling molecule has important implications for the understanding of interactions between bacterial cells...
  40. ncbi Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
    Susan D Demo
    Proteolix, Inc, South San Francisco, California 94080, USA
    Cancer Res 67:6383-91. 2007
    ..These studies show the tolerability, efficacy, and dosing flexibility of PR-171 and provide validation for the clinical testing of PR-171 in the treatment of hematologic malignancies using dose-intensive schedules...
  41. ncbi Once-daily atazanavir/ritonavir compared with twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 96-week efficacy and safety results of the CASTLE study
    Jean Michel Molina
    Department of Infectious Diseases, Hopital Saint Louis 1, Av C Vellefaux, 75475 Paris, Cedex 10, France
    J Acquir Immune Defic Syndr 53:323-32. 2010
    ..Once-daily atazanavir/ritonavir demonstrated similar antiviral efficacy to twice-daily lopinavir/ritonavir over 48 weeks, with less gastrointestinal disturbance and a better lipid profile, in treatment-naive patients...
  42. ncbi Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study
    Hendrik W Reesink
    Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Gastroenterology 131:997-1002. 2006
    ..4A protease of hepatitis C and has antiviral activity in vitro. This phase I, placebo-controlled, double-blind study evaluated the antiviral activity, pharmacokinetics, and safety of VX-950 in patients with chronic hepatitis C (CHC)...
  43. pmc Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
    Deborah J Kuhn
    Lineberger Comprehensive Cancer Center and Department of Medicine, Division of Hematology Oncology, University of North Carolina, Chapel Hill, NC, USA
    Blood 110:3281-90. 2007
    ..Carfilzomib also overcame resistance to other conventional agents and acted synergistically with dexamethasone to enhance cell death. Taken together, these data provide a rationale for the clinical evaluation of carfilzomib in MM...
  44. pmc A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation
    Amit Gaggar
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 180:5662-9. 2008
    ..These experiments highlight unique protease interactions with structural proteins regulating innate immunity and support a role for these peptides as novel biomarkers and therapeutic targets for chronic, neutrophilic lung diseases...
  45. ncbi A potent and selective endogenous agonist for the mu-opiate receptor
    J E Zadina
    Veterans Affairs Medical Center, New Orleans, Louisiana 70146, USA
    Nature 386:499-502. 1997
    ..The new peptides have the highest specificity and affinity for the mu receptor of any endogenous substance so far described and they may be natural ligands for this receptor...
  46. ncbi Desacyl-ghrelin and synthetic GH-secretagogues modulate the production of inflammatory cytokines in mouse microglia cells stimulated by beta-amyloid fibrils
    Ilaria Bulgarelli
    Department of Experimental Medicine, University of Milano Bicocca, Milan, Italy
    J Neurosci Res 87:2718-27. 2009
    ..We conclude that desacyl-ghrelin, hexarelin, and EP80317 might interfere with fAbeta activation of CD36 in microglia cells...
  47. ncbi NAP, a neuroprotective drug candidate in clinical trials, stimulates microtubule assembly in the living cell
    Illana Gozes
    Department of Human Molecular Genetic and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Curr Alzheimer Res 4:507-9. 2007
    ..This data demonstrates that NAP functions as a neuroprotectant, at least in part, through its interaction with tubulin with a resulting increase in microtubule assembly...
  48. pmc A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies
    Owen A O'Connor
    NYU Cancer Institute, NYU Langone Medical Center, 522 First Ave, Smilow 1101, New York, NY, USA
    Clin Cancer Res 15:7085-91. 2009
    ..Proteasome inhibition by carfilzomib is mechanistically irreversible. Consequently, proteasome inhibition is more sustained with carfilzomib than with bortezomib...
  49. ncbi Rapid decrease of wild-type hepatitis C virus on telaprevir treatment
    Bambang S Adiwijaya
    Vertex Pharmaceuticals, Inc, Cambridge, MA, USA
    Antivir Ther 14:591-5. 2009
    ..4A protease inhibitor that has exhibited antiviral activity in patients with HCV genotype 1 infection. The viral dynamics in patients dosed with TVR were compared with those reported for patients treated with interferon (IFN)...
  50. ncbi (64)Cu-labeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression
    Zi Bo Li
    Molecular Imaging Program at Stanford, Department of Radiology and Bio X Program, Stanford University School of Medicine, Stanford, California 94305, USA
    J Nucl Med 48:1162-71. 2007
    ..In this study, we developed (64)Cu-labeled multimeric RGD peptides, E{E[c(RGDyK)](2)}(2) (RGD tetramer) and E(E{E[c(RGDyK)](2)}(2))(2) (RGD octamer), for PET imaging of tumor integrin alpha(v)beta(3) expression...
  51. ncbi Comparison of multiple Amber force fields and development of improved protein backbone parameters
    Viktor Hornak
    Center for Structural Biology, Stony Brook University, Stony Brook, New York 11794, USA
    Proteins 65:712-25. 2006
    ..It also accomplishes improved agreement with published experimental data for conformational preferences of short alanine peptides and better accord with experimental NMR relaxation data of test protein systems...
  52. pmc The N domain of human angiotensin-I-converting enzyme: the role of N-glycosylation and the crystal structure in complex with an N domain-specific phosphinic inhibitor, RXP407
    Colin S Anthony
    Division of Medical Biochemistry, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Anzio Road, Observatory 7925, South Africa
    J Biol Chem 285:35685-93. 2010
    ..0 Å resolution. The Ndom389 structure revealed a hinge region that may contribute to the breathing motion proposed for substrate binding...
  53. pmc RGD peptide-mediated chitosan-based polymeric micelles targeting delivery for integrin-overexpressing tumor cells
    Li Li Cai
    College of Pharmaceutical Science, Zhejiang University, Hangzhou, People s Republic of China
    Int J Nanomedicine 6:3499-508. 2011
    ..Thus, the targeting of RGD-modified micelles to tumor vasculature is a promising strategy for tumor-targeting treatment...
  54. ncbi A protective role for protease-activated receptors in the airways
    T M Cocks
    Department of Pharmacology, University of Melbourne, Parkville, Victoria, Australia
    Nature 398:156-60. 1999
    ..Our results indicate that trypsin released from the epithelium can initiate powerful bronchoprotection in the airways by activation of epithelial PAR2...
  55. ncbi Detection and identification of oligopeptides in Microcystis (cyanobacteria) colonies: toward an understanding of metabolic diversity
    Martin Welker
    Technische Universitat Berlin, Institut für Chemie AG Biochemie und Molekulare Biologie, Franklinstr 29, 10587 Berlin, Germany
    Peptides 27:2090-103. 2006
    ..The high number of peptides and especially the new peptides underline the capability of Microcystis strains as producers of a high diversity of potentially bioactive compounds...
  56. pmc A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation
    Robert J Snelgrove
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham Lung Health Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Science 330:90-4. 2010
    ..These studies imply that therapeutic strategies inhibiting LTA(4)H to prevent LTB(4) generation may not reduce neutrophil recruitment because of elevated levels of PGP...
  57. ncbi The PXY-CLE41 receptor ligand pair defines a multifunctional pathway that controls the rate and orientation of vascular cell division
    J Peter Etchells
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Development 137:767-74. 2010
    ..Parallels with animal systems indicate that localised signalling from adjacent cells is a general mechanism for defining the plane of cell division...
  58. pmc Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy
    Nadia Stefanova
    Division of Neurobiology, Innsbruck Medical University, Innsbruck, Austria
    Acta Neuropathol 124:51-65. 2012
    ..In summary, we provide new evidence supporting a primary role of proteolytic failure and suggesting a neurodegenerative pathomechanism related to disturbed oligodendroglial/myelin trophic support in the pathogenesis of MSA...
  59. ncbi High incidence of renal stones among HIV-infected patients on ritonavir-boosted atazanavir than in those receiving other protease inhibitor-containing antiretroviral therapy
    Yohei Hamada
    AIDS Clinical Center, National Center for Global Health and Medicine, 1 21 1 Toyama, Shinjuku ku, Tokyo, Japan
    Clin Infect Dis 55:1262-9. 2012
    ..Little information is available on the incidence of renal stones with ritonavir-boosted atazanavir (ATV/r) use...
  60. ncbi The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines
    Annie Meiniel
    INSERUM UMR 384 et Laboratoire de Biochimie médicale, F 63001 Clermont Ferrand, France
    Int Rev Cytol 230:1-39. 2003
    ..Integrins and growth factor receptors may cooperate as integrative signals. We discuss the putative involvement of the subcommissural organ/Reissner's fiber complex in developmental events, as a particular extracellular signaling system...
  61. ncbi Chondrocyte redifferentiation in 3D: the effect of adhesion site density and substrate elasticity
    Elena Schuh
    Institute for Biomechanics, ETH Zurich, Zurich, Switzerland
    J Biomed Mater Res A 100:38-47. 2012
    ..This knowledge might be used to optimize the redifferentiation process of chondrocytes and thus the formation of cartilage-like tissue...
  62. ncbi Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats
    C Andrew Boswell
    Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech Research and Early Development, South San Francisco, California 94080, United States
    Bioconjug Chem 22:1994-2004. 2011
    ..Taken together, these results indicate that the degree of overall structural modification in anti-STEAP1-MMAE conjugates has a corresponding level of impact on both PK and tissue distribution...
  63. ncbi Concentration-dependent mechanisms of cell penetration and killing by the de novo designed antifungal hexapeptide PAF26
    Alberto Munoz
    Institute of Cell Biology, University of Edinburgh, Edinburgh, UK
    Mol Microbiol 85:89-106. 2012
    ..Our results provide new mechanistic insights into the mode-of-action of small cationic antimicrobial peptides that should facilitate improvements in their design...
  64. pmc Endomorphin-2: a biased agonist at the μ-opioid receptor
    Guadalupe Rivero
    School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol, UK
    Mol Pharmacol 82:178-88. 2012
    ....
  65. ncbi The relative efficacy of boceprevir and telaprevir in the treatment of hepatitis C virus genotype 1
    Jennifer Kieran
    Departments of Pharmacology and Therapeutics, Trinity College Dublin, Dublin, Ireland
    Clin Infect Dis 56:228-35. 2013
    ..The licensing of direct-acting antivirals heralds a new era in the treatment of hepatitis C virus (HCV) genotype 1. We undertook a mixed treatment comparison to examine the relative efficacy among current treatments for HCV...
  66. ncbi A phase 1/2 study of carfilzomib in combination with lenalidomide and low-dose dexamethasone as a frontline treatment for multiple myeloma
    Andrzej J Jakubowiak
    University of Chicago Medical Center, Chicago, IL 60637 6613, USA
    Blood 120:1801-9. 2012
    ..CRd was well tolerated with exceptional response rates. This study is registered at http://www.clinicaltrials.gov as NCT01029054...
  67. ncbi Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein
    Peter O Bauer
    Laboratory for Structural Neuropathology, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    Nat Biotechnol 28:256-63. 2010
    ....
  68. ncbi Anti-tumor and anti-angiogenic effect of metronomic cyclic NGR-modified liposomes containing paclitaxel
    Li Min Luo
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100191, China
    Biomaterials 34:1102-14. 2013
    ..NGR-SSL-PTX is able to improve treatment efficacy producing the most significant anti-tumor activity and anti-angiogenic following metronomic administration...
  69. ncbi Fast clearing RGD-based near-infrared fluorescent probes for in vivo tumor diagnosis
    Jie Cao
    Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China
    Contrast Media Mol Imaging 7:390-402. 2012
    ..Further, the α(υ)β(3) receptor affinity of the three RGD-based NIR probes followed the order of dimer cyclic > monomer cyclic > linear. The results demonstrate potent fast clearing probes for in vivo early tumor diagnosis...
  70. ncbi Doxorubicin delivery to 3D multicellular spheroids and tumors based on boronic acid-rich chitosan nanoparticles
    Xin Wang
    Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering, College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China
    Biomaterials 34:4667-79. 2013
    ....
  71. pmc Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner
    T T Myöhänen
    Division of Pharmacology and Toxicology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, Helsinki, Finland
    Br J Pharmacol 163:1666-78. 2011
    ..Our results also advocate a role for Ac-SDKP in angiogenesis, and suggest that POP has a pro-angiogenic role via the release of Ac-SDKP from its precursor Tβ4 and POP inhibitors can block this action...
  72. ncbi RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature
    Kai Temming
    Department of Pharmacokinetics and Drug Delivery, Groningen University Institute for Drug Exploration GUIDE, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Drug Resist Updat 8:381-402. 2005
    ..Furthermore the in vitro and in vivo efficacy of RGD-targeted therapeutics and diagnostics reported in recent years will be reviewed...
  73. ncbi Pyoverdines: pigments, siderophores and potential taxonomic markers of fluorescent Pseudomonas species
    J M Meyer
    Laboratoire de Microbiologie et Génétique, UPRES A 7010, Universite Louis Pasteur, Strasbourg, France
    Arch Microbiol 174:135-42. 2000
    ..A promising future is expected from recent developments which indicate that pyoverdines might be considered as potent and easy-to-handle taxonomic markers for the fluorescent species of the genus Pseudomonas...
  74. pmc Facial injections of pruritogens and algogens excite partly overlapping populations of primary and second-order trigeminal neurons in mice
    T Akiyama
    Department of Neurobiology, Physiology and Behavior, University of California, Davis, CA 95616, USA
    J Neurophysiol 104:2442-50. 2010
    ..The results are discussed in terms of population codes for itch and pain that result in distinct behavioral responses of hindlimb scratching and forelimb wiping that are mediated at lumbar and cervical segmental levels, respectively...
  75. ncbi Ritonavir-boosted atazanavir exposure is associated with an increased rate of renal stones compared with efavirenz, ritonavir-boosted lopinavir and ritonavir-boosted darunavir
    Neesha Rockwood
    Department of HIV Medicine, Chelsea and Westminster Hospital, London, UK
    AIDS 25:1671-3. 2011
    ..When choosing a boosted protease inhibitor, ATZ/r renal stones should be considered as a potential comorbidity...
  76. ncbi Antiviral effects of peginterferon alpha-2b and ribavirin following 24-week monotherapy of telaprevir in Japanese hepatitis C patients
    Itaru Ozeki
    Department of Gastroenterology, Sapporo Kosei General Hospital, North 3 East 8, Chuou ku, Sapporo, Hokkaido, 060 0033, Japan
    J Gastroenterol 46:929-37. 2011
    ....
  77. pmc Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen
    Philip J O'Reilly
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 5294 0005, USA
    J Neuroimmunol 217:51-4. 2009
    Prolyl endopeptidase (PE), a protease that cleaves after proline residues in oligopeptides, is highly active in brain and degrades neuropeptides in vitro...
  78. pmc Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis
    Eric A Murphy
    Department of Pathology, Moores Cancer Center, University of California at San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 105:9343-8. 2008
    ..These findings reveal that NP-based delivery of cytotoxic drugs to the alphanubeta3-positive tumor vasculature represents an approach for treating metastatic disease...
  79. pmc Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation
    Cheng Han Yu
    Mechanobiology Institute, National University of Singapore, 5A Engineering Drive 1, Singapore 117411
    Proc Natl Acad Sci U S A 108:20585-90. 2011
    ..Many of these early mechanical steps are not evident in cells spreading on immobilized matrices perhaps because of the low forces involved. These observations can provide new targets to control integrin-dependent adhesion and motility...
  80. ncbi Chronic systemic treatment with a high-dose proteasome inhibitor in mice produces akinesia unrelated to nigrostriatal degeneration
    Masahiro Shin
    Commissariat a l Energie Atomique CEA, Institut d Imagerie Biomédicale I 2 BM, Molecular Imaging Research Center MIRCen, Bât 61, 18 route du Panorama, BP n 6, F 92265 Fontenay aux Roses, France
    Neurobiol Aging 32:2100-2. 2011
    ..However, PSI alone produced no sign of degeneration of the nigrostriatal dopaminergic pathway and did not exacerbate MPTP toxicity. To conclude, PSI administration does not provide a reliable phenotypic model of PD...
  81. ncbi In vitro resistance studies of hepatitis C virus serine protease inhibitors, VX-950 and BILN 2061: structural analysis indicates different resistance mechanisms
    Chao Lin
    Vertex Pharmaceuticals Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 279:17508-14. 2004
    ..Modeling analysis suggests that there are different mechanisms of resistance to VX-950 and BILN 2061...
  82. ncbi The potential of nanoscale combinations of self-assembling peptides and amino acids of the Src tyrosine kinase inhibitor in acute lung injury therapy
    Shan Yu Fung
    Latner Thoracic Surgery Research Laboratories, University Health Network, Toronto General Research Institute, Toronto, Ontario M5G1L7, Canada
    Biomaterials 32:4000-8. 2011
    ..The promising therapeutic efficacy and the formulation strategy developed in this work may help further translate PP2 and other hydrophobic therapeutic agents into clinical applications...
  83. pmc Chemistry and biology of the copper chelator methanobactin
    Grace E Kenney
    Departments of Molecular Biosciences and of Chemistry, Northwestern University, Evanston, Illinois 60208, United States
    ACS Chem Biol 7:260-8. 2012
    ..trichosporium OB3b cells has been demonstrated, and studies of the transport mechanism have been initiated. Taken together, these advances represent significant progress and set the stage for exciting new research directions...
  84. pmc Susceptibility of treatment-naive hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors
    Andrew Bae
    Department of Clinical Virology, Gilead Sciences, 333 Lakeside Dr, Foster City, CA 94404, USA
    Antimicrob Agents Chemother 54:5288-97. 2010
    ..Our results suggest that the natural variation in baseline susceptibility may contribute to different degrees of antiviral response among patients in vivo, particularly at lower doses...
  85. ncbi Pharmacokinetics, pharmacodynamics, metabolism, distribution, and excretion of carfilzomib in rats
    Jinfu Yang
    Onyx Pharmaceuticals, South San Francisco, CA 94080, USA
    Drug Metab Dispos 39:1873-82. 2011
    ..Together with rapid and irreversible target binding, the high clearance may provide an advantage in that "unnecessary" exposure to the drug is minimized and potential drug-related side effects may be reduced...
  86. pmc Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor
    D Chauvier
    Theraptosis Research Laboratory, THERAPTOSIS SA, Pasteur Biotop, Institut Pasteur, Paris 75015, France
    Cell Death Dis 2:e203. 2011
    ..Safety pharmacology investigations, and toxicology studies in rodent and canine neonates, suggest that TRP601 is a lead compound for further drug development to treat ischemic brain damage in human newborns...
  87. ncbi Protection against tauopathy by the drug candidates NAP (davunetide) and D-SAL: biochemical, cellular and behavioral aspects
    Natalia Shiryaev
    The Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv 69978, Israel
    Curr Pharm Des 17:2603-12. 2011
    ..These studies associate neuroprotection in vivo and in vitro and provide a broad base for future drug development based on NAP and D-SAL against multiple neurodegenerative conditions...
  88. pmc Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases
    Haruka Sudo
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 W Queen Lane, Philadelphia, PA 19129, USA
    Hum Mol Genet 20:763-78. 2011
    ..These observations may be useful in developing therapeutic regimes for preserving microtubules against loss in the axons of patients suffering from tauopathies...
  89. pmc A comparison of methanobactins from Methylosinus trichosporium OB3b and Methylocystis strain Sb2 predicts methanobactins are synthesized from diverse peptide precursors modified to create a common core for binding and reducing copper ions
    Benjamin D Krentz
    Department of Chemistry, University of Wisconsin Eau Claire, Eau Claire, Wisconsin 54702 4004, United States
    Biochemistry 49:10117-30. 2010
    ....
  90. pmc Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
    Gianluca Baldanzi
    Department of Medical Sciences and Interdisciplinary Research Center on Autoimmune Diseases, University Amedeo Avogadro of Piemonte Orientale, Novara 28100, Italy
    J Cell Biol 159:1029-37. 2002
    ....
  91. pmc One-step radiosynthesis of ¹⁸F-AlF-NOTA-RGD₂ for tumor angiogenesis PET imaging
    Shuanglong Liu
    Molecular Imaging Program at Stanford, Canary Center at Stanford for Cancer Early Detection, Bio X Program, Department of Radiology, Stanford University, 1201 Welch Road, Lucas Expansion, P095, Stanford, CA 94305 5344, USA
    Eur J Nucl Med Mol Imaging 38:1732-41. 2011
    ....
  92. ncbi NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse--a microtubule-deficient model of schizophrenia
    Avia Merenlender-Wagner
    The Adams Super Center for Brain Studies, The Lily and Avraham Gildor Chair for the Investigation of Growth Factors, The Elton Laboratory for Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Peptides 31:1368-73. 2010
    ..Daily intranasal NAP treatment significantly decreased hyperactivity in the STOP+/- mice and protected visual memory...
  93. pmc Molecular basis of the recognition of nephronectin by integrin alpha8beta1
    Yuya Sato
    Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 284:14524-36. 2009
    ....
  94. pmc Analysis of achromobactin biosynthesis by Pseudomonas syringae pv. syringae B728a
    Andrew D Berti
    Department of Bacteriology, University of Wisconsin Madison, Madison, WI 53706, USA
    J Bacteriol 191:4594-604. 2009
    ..This work provides insights into the biosynthetic steps in the formation of achromobactin and is the first in vitro reconstitution of achromobactin biosynthesis...
  95. pmc Integrin activation dynamics between the RGD-binding site and the headpiece hinge
    Eileen Puklin-Faucher
    Department of Materials, Laboratory of Biologically Oriented Materials, ETH, Zurich CH 8049, Switzerland
    J Biol Chem 284:36557-68. 2009
    ..become strengthened under force), as well as earlier evidence that Ca(2+) at the ADMIDAS results in lower binding affinity, these simulations provide a common structural model for the dynamic process by which integrins become activated...
  96. ncbi Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties
    K Maenaka
    Structural Biology, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford OX3 7BN, United Kingdom
    J Biol Chem 274:28329-34. 1999
    ..These results indicate that KIR/peptide-MHC class I interactions have properties typical of other cell-cell recognition molecules, and they highlight the unusual nature of TCR/peptide-MHC recognition...
  97. pmc Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown
    Saskia Braber
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht Univ, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 300:L255-65. 2011
    ..Together with MMPs, PE may play an important role in the formation of PGP and thus in the pathophysiology of lung emphysema...
  98. ncbi Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition
    Hai Ying Fu
    Department of Cardiovascular Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Cardiovasc Res 79:600-10. 2008
    ..Since ER stress is involved in the development of heart failure, we investigated the role of ER-initiated cardiomyocyte death by proteasome inhibition...
  99. ncbi Ghrelin receptor agonist GHRP-2 prevents arthritis-induced increase in E3 ubiquitin-ligating enzymes MuRF1 and MAFbx gene expression in skeletal muscle
    Miriam Granado
    Dept Fisiologia, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    Am J Physiol Endocrinol Metab 289:E1007-14. 2005
    ..The parallel changes in muscular IGFBP-5 and TNF-alpha gene expression with the ubiquitin ligases suggest that they can participate in skeletal muscle alterations during chronic arthritis...
  100. pmc Characterization of valvular interstitial cell function in three dimensional matrix metalloproteinase degradable PEG hydrogels
    Julie A Benton
    Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309 0424, USA
    Biomaterials 30:6593-603. 2009
    ....
  101. pmc Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages
    Ari S Nowacek
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Control Release 150:204-11. 2011
    ..These studies bring this line of research a step closer to developing nanoART that can be used in the clinic to affect the course of HIV-1 infection...

Research Grants62

  1. Nano-sized Cell Guidance System for Ischemic Tissue Repair
    Hyunjoon Kong; Fiscal Year: 2010
    ..The oligopeptide structure will be varied to improve the binding affinity to cells and VCAM-1. These two oligopeptides will be chemically linked to the poly(glycerol)...
  2. BONE TARGETED DELIVERY OF ANABOLIC AGENTS
    JINDRICH H KOPECEK; Fiscal Year: 2011
    ..by a highly efficient click chemistry reaction with enzymatically degradable (acetylene functionalized) oligopeptides;b) The targeting D-Asp8 group will be bound to the polymer backbone via a cathepsin K sensitive spacer;c) PGE1 ..
  3. Bacterial Quorum Sensing as Target for Anti-Infective Immunotherapy
    Bin Zhou; Fiscal Year: 2013
    ..Subsequently, other quorum sensing systems and signaling molecules have been identified, including oligopeptides in Gram-positive bacteria, such as Staphylococcus aureus...
  4. Antiotensin converting enzyme gene expression
    Ganes C Sen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): ACE is a dipeptidyl carboxypeptidase whose natural substrates include the oligopeptides angiotensin I and bradykinin...
  5. Nanocells for vascular normalization therapies
    Hyunjoon Kong; Fiscal Year: 2013
    ..module, a poly (glycerol) substituted with varying numbers of alkyl chains and leaky endothelium-targeting oligopeptides, and (2) further incorporating into the nanocell via in situ encapsulation, surface-engineered super ..
  6. Structural Relay Methods for Functional Peptide Discovery
    PHILLIP TODD ORDOUKHANIAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Oligopeptides have many functions in biology, including providing binding selectivity that allows proteins to traffic to the proper place in the ell, between cells, within tissues, and throughout the ..
  7. Roles of two aminopeptidases in peptide catabolism in the malaria parasite
    Michael Klemba; Fiscal Year: 2012
    ..While the initial steps in the degradation of hemoglobin to oligopeptides have been well studied, the processes by which amino acids are generated have remained ill-defined...
  8. Dynamically Responsive Bioreactors for Cartilage Regeneration
    Stephanie J Bryant; Fiscal Year: 2013
    ..This aim tests the hypothesis that a hydrogel with crosslinks containing oligopeptides that are degraded by cells, leading to local degradation (critical for local matrix elaboration without ..
  9. AN EXPERIMENTAL APPROACH TO MACULOPATHY
    David R Hinton; Fiscal Year: 2013
    ..We then hypothesize that aB crystallin-derived oligopeptides with chaperone activity can provide similar protection of RPE from oxidative stress and other injuries and can ..
  10. Novel Fibronectin-derived Peptides To Support Optimal Fibroblast Adhesion, Migrat
    RICHARD AUGUST CLARK; Fiscal Year: 2013
    ..To develop a commercially viable tissue-engineered construct, recombinant domains must be replaced by small oligopeptides that: retain activity of domains;can be synthesized on large scale in a cost- effective manner;and resist ..
  11. Is phytochelatin synthase an essential enzyme and drug target for schistosomiasis
    DAVID LEE WILLIAMS; Fiscal Year: 2010
    ..well characterized in plants where they serve as the primary means of sequestering toxic heavy metals, are oligopeptides synthesized from glutathione by PCS...
  12. Analysis of MHC Class Ib-Restricted Polyoma Virus-Specific CD8 T Cells
    ARON LUKACHER; Fiscal Year: 2013
    ..mediated by conventional TCR[unreadable][unreadable] CD8 T lymphocytes that recognize pathogen-derived oligopeptides presented by the highly polymorphic "classical" or MHC class Ia molecules...
  13. Chemical Strategies to Manipulate A1-2 Signaling in Bacterial Pathogens
    Kim D Janda; Fiscal Year: 2013
    ..QS systems have been discovered in Gram-negative and -positive bacteria and a variety of molecules, e.g. oligopeptides and acyl homoserine lactones, have been identified as autoinducers...
  14. Theoretical Studies of Peptide Structures
    JOSEPH J DANNENBERG; Fiscal Year: 2012
    ..molecular orbital theory, both in isolated (gas phase) and solvated completely geometrically optimized oligopeptides. This work will be coordinated with NMR structural determinations of the same peptides where possible...
  15. DOXORUBICIN BIOSYNTHESIS AND RESISTANCE
    CHARLES SIH; Fiscal Year: 2000
    ..the site of protein phosphorylation by limited proteolysis and amino acid sequence analysis of labeled oligopeptides made from DnrN and DnrI. 4...
  16. Oral Biofilms and the Immune System
    Kim Janda; Fiscal Year: 2009
    ..QS factors are small, diffusible molecules of different chemical classes that include the AHL series, oligopeptides, and the ribose-derived DPD/AI-2 molecule. The presence of QS factors in biofilms is well documented...
  17. Modulation of the innate immunity by bacterial signaling molecules
    Vladimir Kravchenko; Fiscal Year: 2009
    ..QS factors are small, diffusible molecules of different chemical classes that include the AHL series, oligopeptides, and the ribose-derived DPD/AI-2 molecule. The presence of QS factors in biofilms is well documented...
  18. FUNCTIONS OF RB PROTEASE(S) IN APOPTOSIS
    QING DOU; Fiscal Year: 2000
    ..be purified by using chromatographic columns of FPLC, RB antibody and the cleavage site- containing synthetic oligopeptides, followed by gel elution...
  19. NEW BIOMEDICAL INTERFACE MATERIALS
    Roger Marchant; Fiscal Year: 2002
    ..range of clinically- relevant biomaterials, and consist of surfactant polymers with pendant oligosaccharides, oligopeptides, and hydrophobic ligands...
  20. LMP POLYMORPHISMS IN B27-ASSOCIATED JUVENILE ARTHRITIS
    Robert Colbert; Fiscal Year: 2001
    ..2 we address the role of LMP subunits in influencing the cleavage site specificity of proteasomes by digesting oligopeptides containing known HLA class I-restricted peptide epitopes...
  21. CHEMICAL REGULATORS OF PHOSPHOLIPID METABOLISM
    BURTON TROPP; Fiscal Year: 1980
    ..We propose the attachment of the analogues to oligopeptides that they may enter the cells through known oligopeptide transport systems (illicit transport)...
  22. GAS PHASE ANALYTICAL CHEMISTRY OF PEPTIDE IONS
    Simon Gaskell; Fiscal Year: 1992
    ..The proposed research will evaluate this hypothesis through analyses of selected oligopeptides using fast atom bombardment- and electrospray-tandem MS (including MS/MS/MS techniques such as sequential ..
  23. HEPATIC BIOSYNTHESIS OF CERULOPLASMIN
    Michael Schilsky; Fiscal Year: 1993
    ..Lectin affinity chromatography and HPLC analysis of oligopeptides will be used to examine differences in oligosaccharide structure...
  24. INTESTINAL AMINOOLIGOPEPTIDASE--SYNTHESIS AND ASSEMBLY
    Gary Gray; Fiscal Year: 1990
    ..vesicles to the brush border membrane surface where it plays an essential role in the surface digestion of oligopeptides of three to seven amino acid residues...
  25. CARDIAC SR: ULTRASTRUCTURE AND IMMUNOCYTOCHEMISTRY
    Donald Ferguson; Fiscal Year: 1993
    ..Electron microscopic studies with monoclonal and polyclonal antibodies, as well as biotinylated oligopeptides, would be performed using thin section, fracture label and deep etch procedures to localize: 1) the Ca2+-..
  26. METABOLISM AND CLINICAL APPLICATION OF OLIGOPEPTIDES
    SIAMAK ADIBI; Fiscal Year: 1991
    For over two decades we have been investigation various questions concerned with assimilation of oligopeptides. These investigations have included transport and hydrolysis of dipeptides and metabolism of their amino acid residues...
  27. MOLECULAR REGULATION OF INTESTINAL AMINOOLIGOPEPTIDASE
    Mitchell Cohen; Fiscal Year: 1991
    ..high concentrations in the intestinal enterocyte, plays an essential role in the surface digestion of nutrient oligopeptides produced by luminal action of pancreatic proteases...
  28. Probing Single-Molecule Neuron-Ligand Pathfinding
    Thomas Beebe; Fiscal Year: 2001
    ..model substrates with a controlled pattern and surface density of laminin, fibronectin and related oligopeptides for neuron and astrocyte attachment and axonal growth studies in the two other Aims; (2) Study neurite ..
  29. Neuropeptidase Function
    David Rodgers; Fiscal Year: 2004
    ..Endopeptidase 24.16 has two unusual properties shared by a number of neuropeptidases: it cleaves only short oligopeptides, and it recognizes a highly diverse set of cleavage sites...
  30. SELF ASSEMBLING OLIGOPEPTIDE BIOMATERIAL
    Douglas Lauffenburger; Fiscal Year: 2000
    ..Abstract): Our goal is development of a new class of synthetic biomaterials based on self-assembly of oligopeptides in aqueous environments...
  31. REGULATION OF NEUTROPHIL CHEMOTAXIS IN INFLAMMATION
    RICHARD PAINTER; Fiscal Year: 1993
    Neutrophils and macrophages possess specific surface receptors for N-formylated oligopeptides and other mediators of inflammation...
  32. STABILITY AND INTERACTIONS OF NUCLEIC ACIDS
    M Record; Fiscal Year: 1999
    ..Our experimental and computational studies will examine homologous series of oligonucleotides and cationic oligopeptides with variable number of charges lZl...
  33. NOVEL OLIGOPEPTIDES AS TOPICAL SKIN LIGHTENING AGENTS
    JAMES LEYDA; Fiscal Year: 2001
    ..Burn victims, the aging and other individuals with skin hyperpigmentation exist by the millions throughout the world. This would be a significant market. The cosmeceutical uses expand the potential many fold. ..
  34. BIOORGANIC APPROACH TO CARBOHYDRATE RECOGNITION
    RANDALL HALCOMB; Fiscal Year: 2001
    ..of the N-acetylglucosaminyl serine glycoprotein linkage point, and substitute these for the parent linkage in oligopeptides. The net effect of these substitutions would be to fix the carbohydrate domain relative to the peptide in ..
  35. DNA SEQUENCE SPECIFIC ALKYLATORS AS NEW ANTITUMOR DRUGS
    Moses Lee; Fiscal Year: 1992
    ..Recent advances in the investigator's understanding of molecular recognition of oligopeptides, such as netropsin and distamcyin, together with the advent of new DNA sequencing and footprinting technology, ..
  36. MUSCLE REGULATORY SYSTEM
    Herbert Cheung; Fiscal Year: 1991
    ..Proteins that are specifically altered in their sequence and synthetic oligopeptides will be used to assist in delineating alternative routes for information transfer...
  37. ROLE OF PAPILLOMAVIRUS IN CERVICAL NEOPLASIA
    Wayne Lancaster; Fiscal Year: 1991
    ..molecular hybridization and immunological tests with antibodies directed against virus type-specific poly- or oligopeptides. HPV sequences will be cloned into plasmid or Charon vectors and subsequently characterized by hybridization ..
  38. ELECTRONICALLY ACTIVE AIB HELICES
    Atsuo Kuki; Fiscal Year: 1992
    The proposed research program is to design and synthetic specific synthetic helical oligopeptides containing beta-(aromatic)- alanines and to measure light-induced electron dynamics from singlet and triplet excited states of these ..
  39. Low-cost custom microarray synthesis
    Erdogan Gulari; Fiscal Year: 2006
    ..monomers with localized acid generation by projection lithography to in situ synthesize oligonucleotides and oligopeptides on simple substrates such as glass slides in a massively parallel fashion...
  40. X-RAY DIFFRACTION STUDIES OF OLIGOPEPTIDES
    Isabella Karle; Fiscal Year: 2007
    ..Among X-ray quality crystals on hand are peptides with gamma-amino residues and some with probable multi-stranded beta sheets. ..
  41. PROTEIN SEQUENCER/MICROBORE HPLC
    JOSEPH NAPOLI; Fiscal Year: 1991
    ..will use sequence information from tryptic digests of partially-purified enzymes/proteins to plan syntheses of oligopeptides and oligonucleotide probes for raising antibodies and cloning the cDNA of the genes of the target proteins...
  42. Regulation of Signaling in Osteoclast Bone Resorption
    Meenakshi Chellaiah; Fiscal Year: 2007
    ..The binding sites of PTP-PEST with N-WASP will be characterized by the delivery of TAT-fused oligopeptides derived from proline-rich regions of PTP-PEST and N-WASP...
  43. MOLECULAR PROBES FOR STUDIES OF MONOCLONALITY
    WALTER NAGEL; Fiscal Year: 1991
    ..the two sequences will be identified and specific oligonucleotide probes complementary to these sequences, and oligopeptides coded by these sequences, will be constructed...
  44. METABOLIC FUELS, DIABETES, AND IGF ACTIVITY
    Lawrence Phillips; Fiscal Year: 1999
    ..fusion protein--permitting affinity isolation; antibodies will be developed with protein fractions and/or oligopeptides. (4) To characterize the physiologic regulation of HpTF, the investigators will use models of insulin ..
  45. Laboratory Syntheses of Mycobacterial tuberculosis LAM Prototypes
    BERTRAM OLIVER FRASER REID; Fiscal Year: 2010
    ..well for completing syntheses of LAM prototypes PUBLIC HEALTH RELEVANCE:Oligosaccharides, oligonucleotides and oligopeptides constitute the three oligomers that are implicated in biological processes, but while the last two have ..
  46. REGULATION OF 06-METHYLGUANINE DNA METHYLTRANSFERASE
    Edward Bresnick; Fiscal Year: 1991
    ..of OMMT from protein that has been separated by SOS-PAGE, prepare antibodies to OMMT by using synthesized oligopeptides, and ascertain the stability of OMMT in the livers of the irradiated rats; and d) determine the specificity of ..
  47. CORONAVIRUS--ANALYSIS OF POLYMERASE GENE PRODUCTS
    Mark Denison; Fiscal Year: 1992
    ..portions of gene A will be produced in rabbits from fusion proteins of gene A cDNA subclones or from synthetic oligopeptides based upon the sequences of these clones...
  48. STEREOCHEMICAL MECHANISM OF SICKLING OF HEMOGLOBIN S
    JEN YANG; Fiscal Year: 1980
    ..Our working hypothesis is that oligopeptides mimicking portions of the amino acid sequence of Hb S at the intermolecular contact sites can interfere with ..
  49. NUTRIENT TRANSPORT MECHANISMS IN MYCOBACTERIA
    Nancy Connell; Fiscal Year: 2004
    ..tuberculosis defective in transport and metabolism of arginine and oligopeptides; (2) to characterize transport of substrates by mutant and wild type BCG and M...
  50. X RAY DIFFRACTION STUDIES OF OLIGOPEPTIDES
    Isabella Karle; Fiscal Year: 2002
    ..X-ray quality single crystals are on hand. ..
  51. MASS SPECTROMETRY OF INVOLATILE BIOMOLECULES
    DOUGLAS BAROFSKY; Fiscal Year: 1990
    ..keV, and ii) to evolve one or more methods capable of detecting less than or equal to 1 pmole of individual oligopeptides without unduly sacrificing the qualitative specificity of the mass spectrometry...
  52. NMR STUDIES OF BIOLOGICALLY IMPORTANT OLIGOSACCHARIDES
    Anthony Serianni; Fiscal Year: 2004
    ..of biologically important 13C-labeled di-, tri-, and tetrasaccharides, either free in solution or tethered to oligopeptides. Scalar couplings involving 15N will also be studied...
  53. CONFORMATIONAL COUPLING WITH PH IN POLYPEPTIDES
    HAROLD SCHERAGA; Fiscal Year: 2002
    ..Recent applications of this methodology to study a series of short oligopeptides have been very successful, and further development and applications of this technique to the present project ..
  54. SYNTHETIC PEPTIDES AS CAPTURE ANTIGEN FOR LYME ELISA
    John Wright; Fiscal Year: 1990
    ..The intent of these studies will be to synthesize six to ten-mere overlapping oligopeptides covering the entire sequence, screen these putative oligopeptide antigens and then against disease state sera...
  55. STUDY OF METAL-BINDING PEPTIDES
    Akira Yoshida; Fiscal Year: 1980
    ..project are: 1) Elucidate the relationships between peptide structure and metal-binding activity of synthetic oligopeptides which contain three cysteine residues; and 2) examine the detoxification effects of the metal-binding peptides ..
  56. Fluorous Solution-Phase Synthesis of Peptides
    Nicola Pohl; Fiscal Year: 2005
    ..goal of the proposed project is to develop a new method for preparative scale syntheses of exceptionally pure oligopeptides, oligosaccharides, and glycopeptides utilizing Fluorous Technologies' proprietary tagging and purification ..
  57. BIOMEDICAL RESEARCH SUPPORT GRANT
    David Katz; Fiscal Year: 1991
    ..will be used for investigations of the structures of complex organic molecules, including natural products, oligopeptides, proteins, and nucleic acids, and studies of the mechanisms of enzyme catalyzed reactions...
  58. METABOLISM OF EXTRACELLULAR MATRIX IN INJURED CORNEAS
    WINSTON KAO; Fiscal Year: 1992
    ..further characterize the proteins encoded by the cDNA clones, antisera will be prepared against the synthetic oligopeptides using information available from cDNA sequences...
  59. ROLES OF PHOSPHOLIPID AND CA2+ IN BRAIN
    JYH FA KUO; Fiscal Year: 1990
    ..the minimal structural determinants of the substrate specificity for PL-Ca-PK will be explored using synthetic oligopeptides. The effects of phosphorylation of MBP and its fragments or peptides on their ability or inability to induce ..
  60. STRUCTURE/FUNCTION ANALYSIS OF ACCHR EPITOPES
    Robert Fairclough; Fiscal Year: 1991
    The central theme of this Program Project is to use monoclonal antibodies (mAbs) directed against defined oligopeptides within the subunits of the nicotinic acetylcholine receptor (AcChR) as site-specific probes of AcChR structure (both ..
  61. Ribozyme-AAV Targeted PS-1 Reduction in Neurons
    Paul Shapshak; Fiscal Year: 2001
    ..Several lines of evidence indicate that amyloid-related protein processing producing toxic oligopeptides including Abeta42 and Abeta40 is associated with neuronal death in AD...
  62. THE ROLE OF NUCLEIC ACIDS IN CELL DIFFERENTIATION
    GEORGE BRAWERMAN; Fiscal Year: 1990
    ..The amino acid sequences of the polypeptides will be deduced through cDNA sequencing, synthetic oligopeptides derived from these sequences will be used to generate antibodies, and the subcellular localization of the ..