cosyntropin

Summary

Summary: A synthetic polypeptide with adrenocorticotropic (CORTICOTROPIN) activity.

Top Publications

  1. ncbi Steroid withdrawal after long-term medication for immunosuppressive therapy in renal transplant patients: adrenal response and clinical implications
    Marco Miozzari
    Renal Division, Department of Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Nephrol Dial Transplant 19:2615-21. 2004
  2. ncbi Comparison of low-dose and high-dose cosyntropin stimulation testing in children
    Ayse Pinar Cemeroglu
    Helen DeVos Children s Hospital, Spectrum Health Medical Group, Michigan State University, Pediatric Endocrinology and Diabetes Clinic, Grand Rapids, Michigan, USA
    Pediatr Int 53:175-80. 2011
  3. ncbi Normal hypothalamic-pituitary-adrenal axis by high-dose cosyntropin testing in patients with abnormal response to low-dose cosyntropin stimulation: a retrospective review
    Maria Fleseriu
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    Endocr Pract 16:64-70. 2010
  4. ncbi High-dose and low-dose cosyntropin stimulation tests for diagnosis of adrenal insufficiency
    Gabriel Dickstein
    Ann Intern Med 140:312-3; author reply 313-4. 2004
  5. ncbi Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamic-pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests
    M Maghnie
    Department of Pediatrics, University of Pavia, Italy
    Eur J Endocrinol 152:735-41. 2005
  6. ncbi Cosyntropin-stimulated salivary cortisol in hospitalized patients with hypoproteinemia
    Hershel Raff
    Endocrine Research Laboratory, Endocrine Diabetes Center, Aurora St Luke s Medical Center, 2801W KK River Pky Suite 245, Milwaukee, WI 53215, USA
    Endocrine 34:68-74. 2008
  7. ncbi Steroid hormone concentration profiles in healthy intact and neutered dogs before and after cosyntropin administration
    L A Frank
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4544, USA
    Domest Anim Endocrinol 24:43-57. 2003
  8. ncbi Can 1 microg of cosyntropin be used to evaluate adrenal insufficiency in critically ill patients?
    Elizabeth F Kozyra
    Medical Surgical ICU, Mount Sinai Hospital, Toronto, Ontario, Canada
    Ann Pharmacother 39:691-8. 2005
  9. ncbi Diagnosis of adrenal insufficiency
    Richard I Dorin
    Division of Endocrinology and Metabolism, New Mexico Veterans Administration Health Care System and University of New Mexico, Medical Service 111, 1501 San Pedro Boulevard SE, Albuquerque, New Mexico 87108, USA
    Ann Intern Med 139:194-204. 2003
  10. ncbi Adrenocortical dysfunction following etomidate induction in emergency department patients
    C L Schenarts
    Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-4700, USA
    Acad Emerg Med 8:1-7. 2001

Research Grants

Detail Information

Publications223 found, 100 shown here

  1. ncbi Steroid withdrawal after long-term medication for immunosuppressive therapy in renal transplant patients: adrenal response and clinical implications
    Marco Miozzari
    Renal Division, Department of Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Nephrol Dial Transplant 19:2615-21. 2004
    ..We have examined the effect of chronic steroid medication on adrenocortical function, and of steroid withdrawal, in immunologically stable renal transplant patients...
  2. ncbi Comparison of low-dose and high-dose cosyntropin stimulation testing in children
    Ayse Pinar Cemeroglu
    Helen DeVos Children s Hospital, Spectrum Health Medical Group, Michigan State University, Pediatric Endocrinology and Diabetes Clinic, Grand Rapids, Michigan, USA
    Pediatr Int 53:175-80. 2011
    There is no consensus among pediatric endocrinologists in using low-dose (LD) versus high-dose (HD) cosyntropin to test for secondary/tertiary adrenal insufficiency...
  3. ncbi Normal hypothalamic-pituitary-adrenal axis by high-dose cosyntropin testing in patients with abnormal response to low-dose cosyntropin stimulation: a retrospective review
    Maria Fleseriu
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    Endocr Pract 16:64-70. 2010
    ....
  4. ncbi High-dose and low-dose cosyntropin stimulation tests for diagnosis of adrenal insufficiency
    Gabriel Dickstein
    Ann Intern Med 140:312-3; author reply 313-4. 2004
  5. ncbi Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamic-pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests
    M Maghnie
    Department of Pediatrics, University of Pavia, Italy
    Eur J Endocrinol 152:735-41. 2005
    ....
  6. ncbi Cosyntropin-stimulated salivary cortisol in hospitalized patients with hypoproteinemia
    Hershel Raff
    Endocrine Research Laboratory, Endocrine Diabetes Center, Aurora St Luke s Medical Center, 2801W KK River Pky Suite 245, Milwaukee, WI 53215, USA
    Endocrine 34:68-74. 2008
    ..Baseline and post cosyntropin-stimulated levels of serum total and salivary cortisol levels were assessed...
  7. ncbi Steroid hormone concentration profiles in healthy intact and neutered dogs before and after cosyntropin administration
    L A Frank
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996 4544, USA
    Domest Anim Endocrinol 24:43-57. 2003
    ..Serum samples were collected before and 1h after cosyntropin administration, and serum concentrations were determined for cortisol, progesterone, 17-OH progesterone (17-OHP)..
  8. ncbi Can 1 microg of cosyntropin be used to evaluate adrenal insufficiency in critically ill patients?
    Elizabeth F Kozyra
    Medical Surgical ICU, Mount Sinai Hospital, Toronto, Ontario, Canada
    Ann Pharmacother 39:691-8. 2005
    To evaluate the utility of cosyntropin 1 microg in assessing adrenal function in critically ill patients.
  9. ncbi Diagnosis of adrenal insufficiency
    Richard I Dorin
    Division of Endocrinology and Metabolism, New Mexico Veterans Administration Health Care System and University of New Mexico, Medical Service 111, 1501 San Pedro Boulevard SE, Albuquerque, New Mexico 87108, USA
    Ann Intern Med 139:194-204. 2003
    The cosyntropin stimulation test is the initial endocrine evaluation of suspected primary or secondary adrenal insufficiency.
  10. ncbi Adrenocortical dysfunction following etomidate induction in emergency department patients
    C L Schenarts
    Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-4700, USA
    Acad Emerg Med 8:1-7. 2001
    ..function at 4, 12, and 24 hours post-induction as assessed by measured serum cortisol response to exogenous cosyntropin (cosyntropin stimulation test, CST). Fisher's exact test was used to compare CST results between groups...
  11. ncbi Increased risk of adrenal insufficiency following etomidate exposure in critically injured patients
    Bryan A Cotton
    Division of Trauma and Surgical Critical Care, Department of Surgery, Vanderbilt University Medical Center, 1211 21st Ave S, 404 Medical Arts Bldg, Nashville, TN 37212, USA
    Arch Surg 143:62-7; discussion 67. 2008
    ..Timely diagnosis and treatment of adrenal insufficiency (AI) dramatically reduces mortality in trauma patients. We sought to identify risk factors and populations with a high risk of developing AI...
  12. ncbi Effects of antidepressant treatment on corticotropin-induced cortisol responses in patients with melancholic depression
    J H Thakore
    Academic Department of Psychological Medicine, Royal London Hospital, UK
    Psychiatry Res 73:27-32. 1997
    ..3 +/- 378.5 nmol/l vs. 595.1 +/- 207.7 nmol/l. Successful pharmacological treatment of major depressive disorder appears to be associated with a reduction in ACTH-induced cortisol release in drug-free patients...
  13. ncbi Diagnosis of adrenal insufficiency in severe sepsis and septic shock
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Faculté de Médecine Paris Ile de France Ouest UVSQ, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Am J Respir Crit Care Med 174:1319-26. 2006
    Diagnosis of adrenal insufficiency in critically ill patients has relied on random or cosyntropin-stimulated cortisol levels, and has not been corroborated by a more accurate diagnostic standard.
  14. ncbi Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans
    Milos Zarkovic
    Institute of Endocrinology, Clinical Center of Serbia, Belgrade, Serbia
    Eur J Endocrinol 159:649-52. 2008
    ..We postulated that higher basal IL6 concentration would be associated with the higher cortisol response to the stimulation...
  15. ncbi [Cosyntropin test in severe active tuberculosis]
    Luis Javier Casanova-Cardiel
    Unidad de Cuidados Intensivos y Medicina Critica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico, D F
    Cir Cir 76:305-9. 2008
    ..Our objective was to investigate adrenal insufficiency with the low-dose cosyntropin test in patients with severe active tuberculosis.
  16. ncbi Prevalence of abnormal adrenocortical function in human immunodeficiency virus infection by low-dose cosyntropin test
    J G Gonzalez-Gonzalez
    Servicio de Endocrinologia, Hospital Universitario Dr José Eleuterio González, Ave Madero y Gonzalitos S N Col Mitras Centro, Monterrey NL, CP 64460, Mexico
    Int J STD AIDS 12:804-10. 2001
    Recent evidence suggests that 10 microg cosyntropin test has higher sensitivity for detecting hypothalamus-hypophysis-adrenal axis (HHA-A) dysfunction...
  17. ncbi Acute relative adrenal insufficiency after aneurysmal subarachnoid hemorrhage
    Kyle A Weant
    Department of Pharmacy Practice and Science, Pharmacy Services, University of Kentucky HealthCare, University of Kentucky College of Pharmacy, Lexington, Kentucky 40536, USA
    Neurosurgery 63:645-9; discussion 649-50. 2008
    ..In this case series, we describe 16 patients evaluated for acute adrenal insufficiency after aneurysmal subarachnoid hemorrhage...
  18. ncbi Visual vignette. Bilateral adrenal calcifications
    John J Orrego
    Division of Endocrinology and Metabolism, Kaiser Permanente, Denver, Colorado, USA
    Endocr Pract 9:572. 2003
  19. ncbi Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress
    Stefan Wüst
    Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany
    J Clin Endocrinol Metab 89:565-73. 2004
    ..These variants may contribute to the individual vulnerability for hypothalamus-pituitary-adrenal-related disorders...
  20. ncbi Adrenal sensitivity to adrenocorticotropin 1-24 is reduced in patients with autoimmune polyglandular syndrome
    R Giordano
    Division of Endocrinology, Department of Internal Medicine, University of Turin, Turin, Italy
    J Clin Endocrinol Metab 89:675-80. 2004
    ..These data are likely to indicate that a reduced sensitivity to ACTH in all adrenal zones occurs in patients with different types of autoimmune disease...
  21. ncbi Sixty-minute post-Synacthen serum cortisol level: a reliable and cost-effective screening test for excluding adrenal insufficiency compared to the conventional short Synacthen test
    S Mansoor
    Department of Pathology and Microbiology, Section of Chemical Pathology, Aga Khan University Hospital, Karachi, Pakistan
    Singapore Med J 48:519-23. 2007
    ..This study was carried out to evaluate the significance of the 60-minute serum cortisol level in SST as a reliable and cost-effective screening test in comparison to the conventional SST...
  22. ncbi ACTH stimulation test in the captive cheetah (Acinonyx jubatus)
    L S Köster
    Veterinary Wildlife Unit, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110 South Africa
    J S Afr Vet Assoc 78:133-6. 2007
    ..No statistically significant rise was seen in the anaesthetised control group following the injection of saline (P = 0.238)...
  23. ncbi [Synacten test]
    Liselotte G Søndergaard Fisker
    Afdeling M, Arhus Sygehus, Arhus Universitetshospital, DK 8000 Arhus C
    Ugeskr Laeger 170:3054-5. 2008
  24. ncbi Adrenal axis testing and corticosteroid replacement therapy in septic shock patients--local and national perspectives
    R S Bourne
    Intensive Care Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, United Kingdom
    Anaesthesia 58:591-6. 2003
    ..Sixty per cent of intensive care units use corticosteroids in septic shock patients, but only 22% use a short synacthen test to guide therapy...
  25. ncbi A trial of intranasal ACTH(1-24) administration to a patient with isolated ACTH deficiency
    Naoki Hiroi
    Division of Diabetes, Metabolism and Endocrinology, Department of Medicine, Toho University School of Medicine, 6 11 1 Omorinshi, Ota ku, Tokyo 143 0015, Japan
    Med Sci Monit 10:CS9-13. 2004
    ..Normally it could be used therapeutically as an alternative to glucocorticoid treatment in these patients. We investigated the possibility of therapeutic approach as intranasal ACTH replacement therapy in patients with ACTH deficiency...
  26. ncbi Secondary hypoadrenalism
    Giuseppe Reimondo
    Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, Universita di Torino, ASO San Luigi, Orbassano 10043, Italy
    Pituitary 11:147-54. 2008
    ..Various alternatives to the ITT, including the standard cosyntropin stimulation test (SST) and low-dose SST, have been proposed since the adrenal gland in SAI loses the capacity ..
  27. ncbi High risk of adrenal insufficiency in adults previously treated for idiopathic childhood onset growth hormone deficiency
    Martin Lange
    Department of Endocrinology, Rigshospitalet, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 88:5784-9. 2003
    ..It is imperative that pituitary axes other than the GH axis are tested at regular intervals, even in the absence of GHD in adulthood...
  28. ncbi Changes in peripheral blood lymphocyte subsets in elderly subjects are associated with an impaired function of the hypothalamic-pituitary-adrenal axis
    Victor Martinez-Taboada
    Services of Rheumatology, Immunology, and Endocrinology, Santander, Spain
    Mech Ageing Dev 123:1477-86. 2002
    ..This association was not found for other steroids and points for the possibility of using DHEA to correct the immunological decline associated with ageing...
  29. ncbi Corticosteroid insufficiency in acutely ill patients
    Mark S Cooper
    Division of Medical Sciences, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    N Engl J Med 348:727-34. 2003
  30. ncbi Hypopituitaric patients with corticotropin insufficiency show marked impairment of the cortisol response to ACTH (1-24) independently of the duration of the disease
    G Aimaretti
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Italy
    J Endocrinol Invest 26:49-55. 2003
    ..In the present study, testing with submaximal ACTH doses did not distinguish patients with secondary adrenal insufficiency from normal subjects...
  31. ncbi Dynamic evaluation of adrenal hypofunction
    L K Nieman
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 1583, USA
    J Endocrinol Invest 26:74-82. 2003
    ..Ultimately, the choice of test should be individualized for each patient, with knowledge of the available reference assays and the vagaries of each test...
  32. ncbi Adrenal suppression and extubation rate after moderately early low-dose dexamethasone therapy in very preterm infants
    Frans J Walther
    Department of Pediatrics, Division of Neonatology, Martin Luther King Jr Charles R Drew University Medical Center and University of California, Los Angeles, CA 90059, USA
    Early Hum Dev 74:37-45. 2003
    ..We conducted a double-blind, randomized study to evaluate whether a moderately early 14-day weaning course of low-dose dexamethasone affects adrenal function and facilitates weaning from the ventilator...
  33. ncbi [Irreversible coma following hypoglycemia in Sheehan syndrome with adrenocortical insufficiency]
    A C Vingerhoeds
    Ned Tijdschr Geneeskd 147:2254; author reply 2254-5. 2003
  34. ncbi Adrenal function in different subgroups of septic shock patients
    D R Salgado
    Intensive Care Unit, Barra D Or Hospital, Rio de Janeiro, RJ, Brazil, and Internal Medicine Department, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Acta Anaesthesiol Scand 52:36-44. 2008
    ....
  35. ncbi An increased capacity for adrenal DHEA release is associated with decreased avoidance and negative mood symptoms in women with PTSD
    Ann M Rasmusson
    Department of Psychiatry, Yale University School of Medicine and VA National Center for PTSD, Clinical Neuroscience Division, VA Boston Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 29:1546-57. 2004
    ....
  36. ncbi [Hypoglycemia due to a disorder of adrenal cortical regulation]
    P Rochiccioli
    Ann Pediatr (Paris) 25:187-90. 1978
  37. ncbi Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma
    Stanley Szefler
    National Jewish Medical and Research Center, 1400 Jackson St, Room J313, Denver, CO 80206, USA
    Chest 128:1104-14. 2005
    ..Inhaled corticosteroids (ICSs) reduce local airway inflammation, which is an underlying cause of asthma symptoms. However, potential systemic side effects associated with ICS use are a major concern for asthmatic patients...
  38. ncbi Autoimmune polyglandular syndrome, type II
    Barbara A Majeroni
    Dept of Family Medicine, State University of New York at Buffalo, Buffalo, New York 14215, USA
    Am Fam Physician 75:667-70. 2007
    ..The conditions usually present in midlife, and women are affected more often than men. The cosyntropin test is recommended for diagnosing adrenal insufficiency, which must be present to diagnose this syndrome...
  39. ncbi Evaluation of adrenal suppression of a lipid enhanced, topical emollient cream formulation of hydrocortisone butyrate 0.1% in treating children with atopic dermatitis
    Lawrence Eichenfield
    Rady Children s Hospital San Diego, San Diego, CA, USA
    Pediatr Dermatol 24:81-4. 2007
    ..1% for up to 4 weeks. At the conclusion of the 4-week treatment period, cosyntropin injection stimulation testing showed no evidence of adrenal suppression...
  40. pmc Adrenocortical suppression increases the risk of relapse in nephrotic syndrome
    Asiri S Abeyagunawardena
    Department of Paediatrics, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    Arch Dis Child 92:585-8. 2007
    ..The degree of hypothalamic-pituitary-adrenal axis (HPA) suppression with such therapeutic strategies has not been studied systematically. HPA suppression could cause a relapse or adrenal crisis...
  41. ncbi Increased adrenal androgen secretion with inhibition of 11beta-hydroxylase in HIV-infected women
    Polyxeni Koutkia
    Program in Nutritional Metabolism and Neuroendocrine Unit, Mass General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Am J Physiol Endocrinol Metab 290:E808-13. 2006
    ..Further studies are needed to assess the physiological effects of this strategy to increase anabolic hormone levels in severe stress, including detailed testing to rule out the potential risk of concomitant adrenal insufficiency...
  42. ncbi Adrenal status in children with septic shock using low-dose stimulation test
    Manjunatha Sarthi
    Neurobiochemistry, Neurosciences Center, All India Institute of Medical Sciences, New Delhi, India
    Pediatr Crit Care Med 8:23-8. 2007
    ..We conducted a prospective study to determine the prevalence of adrenal insufficiency in children with septic shock using a low-dose Synacthen (1 microg) stimulation test...
  43. ncbi Assessment of adrenal suppression in children with asthma treated with inhaled corticosteroids: use of dehydroepiandrosterone sulfate as a screening test
    Morna J Dorsey
    Division of Immunology, Children s Hospital Boston, Harvard Medical School, Massachusetts, USA
    Ann Allergy Asthma Immunol 97:182-6. 2006
    ..Dehydroepiandrosterone sulfate (DHEA-S) is a corticotropin-dependent adrenal androgen precursor that is suppressible in patients treated with ICs...
  44. pmc Adrenal responses to low dose synthetic ACTH (Synacthen) in children receiving high dose inhaled fluticasone
    J Paton
    Division of Developmental Medicine, University of Glasgow, Royal Hospital for Sick Children, Glasgow G3 8SJ, Scotland, UK
    Arch Dis Child 91:808-13. 2006
    ..Following two cases of serious adrenal insufficiency (one fatal) attributed to FP, adrenal function was evaluated in children receiving FP outwith the licensed dose...
  45. pmc Adrenal insufficiency in acute spinal cord injury
    Inigo A Garcia-Zozaya
    James A Haley VA Hospital, Spinal Cord Injury Service 128, 13000 Bruce B Downs Boulevard, Tampa, FL 33612, USA
    J Spinal Cord Med 29:67-9. 2006
    ..to vasopressors and volume replacement 2 weeks after injury and was diagnosed with adrenal insufficiency by cosyntropin test...
  46. ncbi [Chronic and acute adrenal insufficiency in surgical practice]
    A E Borisov
    Vestn Khir Im I I Grek 165:59-62. 2006
  47. ncbi Hypothalamic-pituitary-adrenal axis activity in adults who were prenatally exposed to the Dutch famine
    Susanne R de Rooij
    Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, 1100DD Amsterdam, The Netherlands
    Eur J Endocrinol 155:153-60. 2006
    ..In this study, we tested the hypothesis that prenatal exposure to famine during different periods of gestation is associated with increased activity of the HPA axis...
  48. ncbi Effect of ciclesonide and fluticasone on hypothalamic-pituitary-adrenal axis function in adults with mild-to-moderate persistent asthma
    Brian J Lipworth
    Allergy Research Group, Department of Medicine and Therapeutics, University of Dundee, Dundee, Scotland
    Ann Allergy Asthma Immunol 94:465-72. 2005
    ..Ciclesonide (hydrofluoroalkane propellant) is a novel inhaled corticosteroid with few, if any, clinical adverse events...
  49. ncbi Echocardiographic features, mortality, and adrenal function in patients with cirrhosis and septic shock
    S Thierry
    Réanimation Chirurgicale, Centre Cardiologique du Nord, Saint Denis, Paris, France
    Acta Anaesthesiol Scand 52:45-51. 2008
    ..The secondary objective was to determine whether adrenal insufficiency, which may contribute to hyperdynamic syndrome, was more marked in patients with cirrhosis than in other patients with septic shock...
  50. ncbi Relative adrenal insufficiency in post-cardiac arrest shock is under-recognized
    Joseph B Miller
    Henry Ford Hospital, Department of Emergency Medicine, 2799 West Grand Boulevard, Detroit, MI 48202, United States
    Resuscitation 76:221-5. 2008
    ..We sought to investigate current clinical practice pertaining to the evaluation for relative adrenal insufficiency in post-cardiac arrest shock...
  51. ncbi Moderate weight loss reduces renin and aldosterone but does not influence basal or stimulated pituitary-adrenal axis function
    J T Ho
    Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Horm Metab Res 39:694-9. 2007
    ..There may be a threshold effect of weight loss/energy restriction required to alter HPA axis function, or moderate weight loss may lead to a counterbalanced effect of stimulatory and inhibitory influences on HPA axis function...
  52. ncbi Morning salivary cortisol versus short Synacthen test as a test of adrenal suppression
    Rajan S Patel
    Department of Otolaryngology, North Glasgow Hospitals University, NHS Trust, Glasgow, UK
    Ann Clin Biochem 41:408-10. 2004
    ....
  53. ncbi Hypothyroidism and adrenal insufficiency in sepsis and hemorrhagic shock
    Hao Chih Ho
    Department of Surgery, Division of Surgical Critical Care, John A Burns School of Medicine, University of Hawaii, and the Queen s Medical Center, Honolulu, Hawaii 96813, USA
    Arch Surg 139:1199-203. 2004
    ..We hypothesized that hypothyroidism and adrenal insufficiency frequently occur together in critically ill patients...
  54. ncbi Effect of desonide hydrogel 0.05% on the hypothalamic-pituitary-adrenal axis in pediatric subjects with moderate to severe atopic dermatitis
    Lawrence F Eichenfield
    Rady Children s Hospital, School of Medicine, University of California, San Diego, California, USA
    Pediatr Dermatol 24:289-95. 2007
    ..of adrenal function was observed in subjects who completed the study without protocol violations related to cosyntropin administration or cortisol testing (n=34)...
  55. ncbi Effect of low doses of cosyntropin on serum cortisol concentrations in clinically normal dogs
    Linda G Martin
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610
    Am J Vet Res 68:555-60. 2007
    To determine the lowest of 5 doses of cosyntropin (1.0, 0.5, 0.1, 0.05, or 0.01 microg/kg) administered IV that stimulates maximal cortisol secretion in clinically normal dogs.
  56. ncbi An update on the biochemical diagnosis of congenital ACTH insufficiency
    Ameeta Mehta
    London Centre of Paediatric Endocrinology and Metabolism, Great Ormond Street Children s Hospital and the Institute of Child Health, University College London, London, UK
    Clin Endocrinol (Oxf) 62:307-14. 2005
    ..The standard Synacthen test (SST) is safe and easy to perform in infancy, but its performance has not been well evaluated in infants and children with ACTH insufficiency...
  57. pmc Dissection of hypothalamic-pituitary-adrenal axis pathology in 1-month-abstinent alcohol-dependent men, part 1: adrenocortical and pituitary glucocorticoid responsiveness
    Bryon Adinoff
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75216, USA
    Alcohol Clin Exp Res 29:517-27. 2005
    ....
  58. ncbi Profile, mean residence time of ACTH and cortisol responses after low and standard ACTH tests in healthy volunteers
    P Alia
    Department of Clinical Chemistry, Hormone and Genetics Unit, IDIBELL Hospital Universitari de Bellvitge, Barcelona, Spain
    Clin Endocrinol (Oxf) 65:346-51. 2006
    ....
  59. ncbi The clinical importance of adrenal insufficiency in acute hepatic dysfunction
    Rachael Harry
    Institute of Liver Studies, Kings College Hospital, London, England
    Hepatology 36:395-402. 2002
    ..01). In conclusion, adrenal dysfunction assessed by the SST is common in AHD and may contribute to hemodynamic instability and mortality. It is more frequent in those with severe liver disease and correlates with severity of illness...
  60. ncbi Effects of intranasal corticosteroids on the hypothalamic-pituitary-adrenal axis in children
    A L Boner
    Department of Pediatrics, University of Verona, Italy
    J Allergy Clin Immunol 108:S32-9. 2001
    ..It is unlikely that children are more sensitive to corticosteroids than are adults. There seems to be little point in performing routine monitoring of adrenal function in children who are treated with intranasal corticosteroid treatment...
  61. ncbi Cortisol secretion and rate of bone loss in a population-based cohort of elderly men and women
    R M Reynolds
    Endocrinology Unit, University of Edinburgh, Queens Medical Research Institute, EH16 4TJ Edinburgh, UK
    Calcif Tissue Int 77:134-8. 2005
    ..These data provide evidence that circulating endogenous glucocorticoids influence the rate of involutional bone loss in healthy individuals...
  62. ncbi Elderly subjects show severe impairment of dehydroepiandrosterone sulphate and reduced sensitivity of cortisol and aldosterone response to the stimulatory effect of ACTH(1-24)
    R Giordano
    Division of Endocrinology, Department of Internal Medicine, University of Turin, Italy
    Clin Endocrinol (Oxf) 55:259-65. 2001
    ..This evidence indicates a reduced sensitivity to ACTH in the fasciculata and glomerulosa zones of the adrenal gland in ageing...
  63. ncbi Dose response relationship between plasma ACTH and cortisol after the infusion of ACTH1-24
    K R Krishnan
    Department of Psychiatry, Duke University Medical Center, Durham, NC
    Eur Arch Psychiatry Clin Neurosci 242:240-3. 1993
    ..Although there was considerable variability in plasma ACTH concentrations, there was, however, a definite correlation between area under the curve for ACTH and area under the curve for cortisol after the various doses of ACTH...
  64. ncbi Effects of oral prasterone (dehydroepiandrosterone) on single-dose pharmacokinetics of oral prednisone and cortisol suppression in normal women
    G M Meno-Tetang
    Department of Pharmaceutical Sciences, School of Pharmacy, State University of New York at Buffalo, 14260, USA
    J Clin Pharmacol 41:1195-205. 2001
    ..Chronic dosing with 200 mg/day of prasterone did not alter either prednisolone pharmacokinetics or inhibition of cortisol secretion by prednisolone...
  65. ncbi Hemodynamic steroid responsiveness is predictive of neurological outcome after traumatic brain injury
    Francis Bernard
    University Department of Critical Care Medicine and General Internal Medicine, Hôpital du Sacré Coeur, Montreal, Quebec, Canada
    Neurocrit Care 5:176-9. 2006
    ..To determine the impact of physiologic doses of hydrocortisone on neurologic outcome after traumatic brain injury (TBI)...
  66. ncbi No major effect of orciprenaline and propranolol upon ACTH-induced cortisol secretion
    A Nonell
    Central Institute of Mental Health, Mannheim, Germany
    Exp Clin Endocrinol Diabetes 112:59-61. 2004
    ..Neither baseline nor ACTH-induced steroid secretion differed between these conditions. Our data do not support the hypothesis that the adrenal beta-receptor plays a major role in steroid secretion in humans...
  67. ncbi Adrenocorticotropin stimulation tests in patients with hypothalamic-pituitary disease: low dose, standard high dose and 8-h infusion tests
    E J Nye
    Department of Medicine, The University of Queensland, Brisbane, Australia
    Clin Endocrinol (Oxf) 55:625-33. 2001
    ..1 microg) or a high dose prolonged infusion does not greatly improve the sensitivity of ACTH [1-24] testing. Dynamic tests that provide a central stimulus remain preferable in the assessment of patients with suspected ACTH deficiency...
  68. ncbi Androgen dependence of hirsutism, acne, and alopecia in women: retrospective analysis of 228 patients investigated for hyperandrogenism
    Sandra Karrer-Voegeli
    Department of Internal Medicine, University Hospital, Lausanne, Switzerland
    Medicine (Baltimore) 88:32-45. 2009
    ..1%); nonclassical congenital adrenal hyperplasia (4 patients; 1.8% of total, 4.9% of patients undergoing cosyntropin stimulation tests); and ovarian tumor (2 patients; 0.9%)...
  69. ncbi Hypothalamic pituitary adrenal function during critical illness: limitations of current assessment methods
    Baha M Arafah
    Division of Clinical and Molecular Endocrinology, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Clin Endocrinol Metab 91:3725-45. 2006
    ....
  70. ncbi Alpha-amidated peptides derived from pro-opiomelanocortin in human pituitary tumours
    M Fenger
    Department of Clinical Chemistry KK, University Hospital of Copenhagen, Denmark
    J Endocrinol 118:329-38. 1988
    ..The main difference between the tumours and the normal pituitary was the greater amount of peptides produced, particularly alpha-MSH and gamma 1-MSH...
  71. ncbi Megestrol acetate-associated adrenal insufficiency
    Deepti Bulchandani
    Department of Internal Medicine, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Am J Geriatr Pharmacother 6:167-72. 2008
    ..Megestrol acetate (MA) is commonly used to promote weight gain in malnourished elderly patients. Although adrenal insufficiency has been reported as an adverse effect of MA, this association is not well recognized in clinical practice...
  72. ncbi Carriers for type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) deficiency can only be identified by HSD3B2 genotype study and not by hormone test
    Songya Pang
    Department of Pediatrics, University of Illinois, College of Medicine, Chicago, IL 60612, USA
    Clin Endocrinol (Oxf) 58:323-31. 2003
    ....
  73. ncbi Release of aldosterone and catecholamines from the interrenal gland of Triturus carnifex in response to adrenocorticotropic hormone (ACTH) administration
    A Capaldo
    Department of Evolutive and Comparative Biology, University of Naples Federico II, 80134 Naples, Italy
    J Morphol 262:692-700. 2004
    ..Finally, the lack of an increase of A content in the chromaffin cells, or A serum level, following ACTH administration in June might suggest an independence of PNMT enzyme on corticosteroids...
  74. ncbi [Adrenocortical function in patients with systemic mycoses]
    Julmery Jesús Cermeño-V
    Departamento de Medicina, Hospital Universitario Ruiz y Paez, Ciudad Bolivar, Venezuela
    Invest Clin 48:341-8. 2007
    ..In patients with systemic mycoses, it is important to evaluate the response to the test of fast stimulation with ACTH due to the frequency of impairment of the glucocorticoid adrenal function in our location...
  75. ncbi The low-dose (1 microg) cosyntropin test (LDT) for primary adrenocortical insufficiency: Defining the normal cortisol response and report on first patients with Addison disease confirmed with LDT
    M Pura
    Department of Endocrinology, National Institute of Endocrinology and Diabetology, Lubochna, Slovakia
    Exp Clin Endocrinol Diabetes 118:151-7. 2010
    The validity of low-dose 1 microg cosyntropin test (LDT) is reported mainly for the assessment of secondary adrenocortical insufficiency (AI)...
  76. pmc The incidence of relative adrenal insufficiency in patients with septic shock after the administration of etomidate
    Zulfiqar Mohammad
    Department of Cardiothoracic Anesthesiology, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Crit Care 10:R105. 2006
    ..The objective of this study was to determine the incidence of relative adrenal insufficiency in patients with septic shock after etomidate administration compared with patients with septic shock who did not receive etomidate...
  77. ncbi Acquired partial corticosterone methyl oxidase type II defect in diabetes mellitus. Case of hyperreninemic hypoaldosteronism
    S S Braithwaite
    Department of Medicine, Loyola University Medical Center, Maywood, Illinois 60153
    Diabetes Care 13:790-2. 1990
    ..One hour after administration of 0.25 mg i.m. cosyntropin, cortisol increased normally, aldosterone increased from 220 to 360 pM, and 18-OHB increased from 3700 to 4800 ..
  78. ncbi Increased adrenal steroid secretion in response to CRF in women with hypothalamic amenorrhea
    A D Genazzani
    Department of Obstetrics and Gynecology, University of Modena, Via del Pozzo 71, 41100, Modena, Italy
    J Steroid Biochem Mol Biol 78:247-52. 2001
    ..To evaluate adrenal steroid hormone secretion in response to corticotropin-releasing factor (CRF) or to adrenocorticotropin hormone in women with hypothalamic amenorrhea...
  79. ncbi Virilizing ovarian Leydig cell tumor in a woman with subclinical Cushing syndrome
    Dima L Diab
    Department of Endocrinology, The Cleveland Clinic, OH 44195, USA
    Endocr Pract 14:358-61. 2008
    ..To report the case of a patient with a virilizing ovarian Leydig cell tumor and subclinical Cushing syndrome attributable to an adrenal adenoma...
  80. ncbi Absence of nonclassical congenital adrenal hyperplasia in patients with precocious adrenarche
    A H Morris
    Department of Pediatrics, Baystate Medical Center, Springfield, Massachusetts 01199
    J Clin Endocrinol Metab 69:709-15. 1989
    ..0 nmol/L) and 10.4, respectively]. In conclusion, we could not provide any biochemical evidence for nonclassical congenital adrenal hyperplasia in a large group of children with precocious adrenarche...
  81. ncbi Virilizing adrenal ganglioneuroma in a woman with subclinical Cushing syndrome
    Dima L Diab
    Department of Endocrinology, The Cleveland Clinic, Cleveland, OH 44195, USA
    Endocr Pract 14:584-7. 2008
    ..To describe a patient with a virilizing adrenal ganglioneuroma and subclinical Cushing syndrome...
  82. ncbi Effect of periconceptional undernutrition and gender on hypothalamic-pituitary-adrenal axis function in young adult sheep
    D S Gardner
    Centre for Reproduction and Early Life, Schools of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, Leicestershire LE12 5RD, UK
    J Endocrinol 190:203-12. 2006
    ..In conclusion, the present study has shown that periconceptional undernutrition of sheep has only a minor influence on HPA axis function in their young adult offspring when considered alongside the effect of gender per se...
  83. ncbi [Adrenal cortex function in patients with AIDS and healthy HIV-positive persons]
    H K Berg
    Rigshospitalet, , epidemiafdelingen, , Patologisk Institut
    Ugeskr Laeger 153:2009-12. 1991
    ..Relative adrenal insufficiency may occur in severely ill preterminal patients as a result of primary target organ failure, but the pituitary-adrenal axis generally appears to be undisturbed...
  84. pmc Use of steroid profiles in determining the cause of adrenal insufficiency
    Jennifer P Holst
    Center for Diabetes and Endocrinology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Steroids 72:71-84. 2007
    ..The study objective was to determine whether a steroid profile, created by simultaneous measurement of 10 steroid hormones by tandem mass spectrometry, would help determine the cause of adrenal insufficiency...
  85. ncbi Hydrocortisone butyrate 0.1% cream (proprietary lipid rich cream vehicle) does not significantly suppress hypothalamic-pituitary-adrenal axis and is effective in pediatric patients 3 months and older with extensive atopic dermatitis
    William Abramovits
    Baylor University Medical Center, The University of Texas Southwestern Medical School at Dallas, Dallas, TX, USA
    Skinmed 8:150-4. 2010
    ..This study adds hydrocortisone butyrate 0.1% cream, to the short list of corticosteroids that have been proven effective and safe by the cosyntropin suppression test in children 3 months and older with widespread atopic dermatitis.
  86. ncbi Hormonal profiles and embryo survival of sows subjected to induced stress during days 13 and 14 of pregnancy
    P Razdan
    Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Centre for Reproductive Biology in Uppsala CRU, Swedish University of Agricultural Sciences SLU, P O Box 7039, SE 750 07 Uppsala, Sweden
    Anim Reprod Sci 81:295-312. 2004
    ..The results of the present study suggest a capacity of the sow to compensate for the influence of induced moderate stress at the time of pregnancy when maternal recognition occurs...
  87. ncbi Use of morning serum cortisol level after transsphenoidal resection of pituitary adenoma to predict the need for long-term glucocorticoid supplementation
    Nicholas F Marko
    Department of Neurosurgery, Brain Tumor and Neuro Oncology Center, Cleveland Clinic, Cleveland, OH, USA
    J Neurosurg 111:540-4. 2009
    ..The authors examine the role of the morning total serum cortisol level in the early postoperative period as a predictor of long-term HPA function...
  88. ncbi Efficacy and safety of triamcinolone acetonide aqueous nasal spray in children aged 2 to 5 years with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled study with an open-label extension
    Steven Weinstein
    Allergy and Asthma Specialists Medical Group and Research Center, Huntington Beach, California 92647, USA
    Ann Allergy Asthma Immunol 102:339-47. 2009
    ..Intranasal corticosteroids (INSs) are the most effective treatment for allergic rhinitis (AR). However, available INS safety and efficacy data in children younger than 6 years are limited...
  89. ncbi Adrenal steroidogenesis in very low birth weight preterm infants
    R V Hingre
    Department of Pediatrics, State University of New York Health Science Center, Syracuse 13210
    J Clin Endocrinol Metab 78:266-70. 1994
    ....
  90. ncbi Pericarditis with cardiac tamponade and addisonian crisis as the presenting features of autoimmune polyglandular syndrome type II: a case series
    Juma M Alkaabi
    Department of Internal Medicine, United Arab Emirates University, Al Ain, United Arab Emirates
    Endocr Pract 14:474-8. 2008
    ..To present 3 cases of cardiac tamponade and addisonian crisis as the presenting features of autoimmune polyglandular syndrome (APS) type II...
  91. ncbi Adrenal cortex autoantibodies in subjects with normal adrenal function
    Corrado Betterle
    Endocrine Unit, Department of Medical and Surgical Sciences, University of Padova, Via Ospedale Civile 105, 35100 Padova, Italy
    Best Pract Res Clin Endocrinol Metab 19:85-99. 2005
    ..Patients with different risk scores need to be monitored at different time intervals, and those at high risk need to be strictly monitored and are the ideal subjects for future prevention trials...
  92. ncbi Neonatal screening for congenital adrenal hyperplasia
    Perrin C White
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9063, USA
    Nat Rev Endocrinol 5:490-8. 2009
    ..screen results, levels of serum electrolytes and 17-hydroxyprogesterone should be immediately determined, but the most reliable way to diagnose CAH is measurement of levels of steroid precursors after stimulation with cosyntropin.
  93. ncbi An enzyme-linked immunosorbent assay for corticosteroid-binding globulin using monoclonal and polyclonal antibodies: decline in CBG following synthetic ACTH
    John G Lewis
    Steroid and Immunobiochemistry Laboratory, Canterbury Health Laboratories, PO Box 151, Christchurch, New Zealand
    Clin Chim Acta 328:121-8. 2003
    ..We have developed and validated an enzyme-linked immunosorbent assay (ELISA) for CBG and together with plasma cortisol calculated the "free cortisol index" as an additional parameter for assessing adrenal function...
  94. ncbi Relations between oral stereotypies, open-field behavior, and pituitary-adrenal system in growing dairy cattle
    I Redbo
    Swedish University of Agricultural Sciences, Department of Animal Nutrition and Management, Kungsängen Research Centre, Uppsala
    Physiol Behav 64:273-8. 1998
    ....
  95. ncbi A patient with diabetes insipidus, anterior hypopituitarism and pituitary stalk thickening
    Nicholas A Tritos
    Neuroendocrine Unit, Massachusetts General Hospital, Zero Emerson Place, Boston, MA 02114, USA
    Nat Rev Endocrinol 7:54-9. 2011
    ..A 42-year-old woman presented to the neuroendocrine unit of a hospital with recent-onset polydipsia, polyuria and oligomenorrhea. She had no visual symptoms, head injury or history of malignancy...
  96. ncbi Relative adrenal insufficiency in dogs with sepsis
    Jamie M Burkitt
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    J Vet Intern Med 21:226-31. 2007
    ..It is unknown whether relative adrenal insufficiency occurs in septic dogs...
  97. ncbi The effect of thyrotoxicosis on adrenocortical reserve
    A Tsatsoulis
    Endocrine Unit, Department of Medicine, University of Ioannina School of Medicine, Ioannina, 451 10, Greece
    Eur J Endocrinol 142:231-5. 2000
    ..This study aimed to assess adrenocortical reserve in response to low-dose ACTH, following dexamethasone suppression, in patients with severe thyrotoxicosis...
  98. ncbi Endocrine and immunogenetic testing in individuals with type 1 diabetes and 21-hydroxylase autoantibodies: Addison's disease in a high-risk population
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, Colorado 80262, USA
    J Clin Endocrinol Metab 90:128-34. 2005
    ..1 had AD-free survival of 60% compared with 100% AD-free survival in those who were not homozygous for MICA5.1. Homozygosity for MICA5.1 may increase progression to overt AD among 21-OHAA-positive individuals...
  99. ncbi Withdrawal of corticosteroids in inflammatory bowel disease patients after dependency periods ranging from 2 to 45 years: a proposed method
    S J Murphy
    Centre for Colorectal Disease, St Vincent s University Hospital, Dublin, Ireland
    Aliment Pharmacol Ther 30:1078-86. 2009
    ..Even in the biologic era, corticosteroid dependency in IBD patients is common and causes a lot of morbidity, but methods of withdrawal are not well described...
  100. ncbi Effect of repeated ACTH-stimulation on early embryonic development and hormonal profiles in sows
    P Razdan
    Department of Obstetrics and Gynaecology, Center for Reproductive Biology in Uppsala CRU, Swedish University of Agricultural Sciences, P O Box 7039, SE 750 07 Uppsala, Sweden
    Anim Reprod Sci 70:127-37. 2002
    ....
  101. ncbi Adrenocorticotropin-induced hypertension in rats: role of ouabain-like compound
    K Yamada
    Department of Human Dry Dock, Sanraku Hospital, Chiyoda-ku, Tokyo, Japan
    Am J Hypertens 10:403-8. 1997
    ..These results suggest the contribution of OLC to ACTH-induced hypertension in rats...

Research Grants23

  1. Fusion Proteins As Probes of P450 Structure and Function
    Richard Auchus; Fiscal Year: 2004
    ..In addition, this approach might be generally applicable to structural studies of membrane-bound proteins. ..
  2. MOLECULAR GENETICS OF LOW RENIN HYPERTENSION
    Perrin White; Fiscal Year: 2001
    ..The investigators will determine the role of 11-HSD K in the development of essential hypertension, using both linkage and association studies. ..
  3. Biochemical Basis of Cortisone Reductase Deficiency
    Perrin White; Fiscal Year: 2007
    ..Subsets of the genotyping data will be analyzed as an association study, as an affected sib pair study, and by transmission disequilibrium testing. Additional polymorphisms in these genes will be sought in PCOS subjects. ..
  4. Childhood Asthma Research and Education Network: Denver Site
    Stanley Szefler; Fiscal Year: 2008
    ..End of abstract.) [unreadable] [unreadable]..
  5. IMMUNE MECHANISMS OF MIDDLE EAR DISEASE
    David Skoner; Fiscal Year: 2006
    ..The primary hypothesis is that cytokine genotype is predictive of illness expression and of OM incidence during a documented RSV infection in young children. ..
  6. LIMBIC SENSITIVITY IN COCAINE ADDICTION
    Bryon Adinoff; Fiscal Year: 2005
    ..Our competing renewal will be used to identify specific changes in these neuroreceptor systems, providing avenues for new pharmacologic investigations in the treatment of cocaine dependence. ..
  7. Prophylaxis of adrenal insufficiency to prevent CLD
    Kristi Watterberg; Fiscal Year: 2005
    ..If this study confirms the benefits seen in the pilot study, it will result in a significant improvement in health care for premature infants, both by introducing a beneficial new therapy, and by avoiding higher dose dexamethasone. ..
  8. Angiotensin, Sodium and Genes in Primate Hypertension
    Robert Shade; Fiscal Year: 2005
    ..Importantly, this work will also reveal whether the genetically determined phenotype of high SLC is important in predisposing an animal to sodium-dependent hypertension. ..
  9. MECHANISMS AND STRATEGIES FOR INSULIN RESISTANCE IN AIDS
    Steven Grinspoon; Fiscal Year: 2004
    ..The proposed studies represent a significant collaborative effort between clinical researchers, adipocyte biologists, epidemiologists and nutritional biochemists in satisfaction of the mandate of the RFA. ..
  10. EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION
    Robert Shade; Fiscal Year: 2003
    ..Thus, the design of the proposed laboratory facility will provide efficient space currently needed by these programs while also improving the collaborative research environment for faculty and staff. ..
  11. NUTRITION ACADEMIC AWARD
    Robert Knopp; Fiscal Year: 2002
    ..It is time to begin aggressive, substantive nutrition educational programs in cardiovascular disease prevention. ..
  12. REGULATION OF HUMAN ALDOSTERONE SYNTHASE
    Perrin White; Fiscal Year: 2002
    ..These studies should provide insight into mechanisms underlying a genetic risk factor for cardiovascular disease. ..
  13. Androgen Effects in HIV-Infected Women
    Steven Grinspoon; Fiscal Year: 2007
    ..The studies outlined in this renewal constitute an important investigative initiative of a targeted, gender-specific therapy in this largely understudied population. ..
  14. STRUCTURAL DETERMINANTS OF NEUROENDOCRINE RECEPTORS
    Carrie Haskell Luevano; Fiscal Year: 2008
    ..abstract_text> ..
  15. Functions of Very Large G-protein Coupled Receptor-1
    Perrin White; Fiscal Year: 2008
    ..We are specifically interested in the other proteins with very large ectodomains, protocadherin- 15 and cadherin-23. These studies should shed new light on mechanisms controlling development of the retina and inner ear. ..
  16. DIETS FOR DYSLIPIDEMIA IN THE METABOLIC SYNDROME
    Robert Knopp; Fiscal Year: 2009
    ..This study will be the first to demonstrate dietary benefit for dyslipidemia, inflammation and vascular stress in MetS at stable weight. ..
  17. Mentored Patient-Oriented Research Career Development Award
    Jacqueline Jonklaas; Fiscal Year: 2006
    ..A new sustained release product, which results in steady triiodothyronine levels, will furnish more physiologic replacement. This will be tested against treatment with levothyroxine, and levothyroxine and triiodothyronine. ..
  18. PERINATAL HYPOXIA: ADRENOCORTICAL-METABOLIC ADAPTATIONS
    Hershel Raff; Fiscal Year: 2006
    ..Characterization of the hypothalamic-pituitary-adrenal and metabolic adaptations to perinatal hypoxia can lead to new diagnostic approaches and therapies to minimize morbidity and mortality. ..
  19. ETIOLOGY, HORMONAL CRITERIA OF 3 BETA HSD DEFICIENCY
    Songya Pang; Fiscal Year: 2002
    ....
  20. PHARMACOLOGIC DISSECTION OF THE HPA AXIS IN ALCOHOLISM
    Bryon Adinoff; Fiscal Year: 2002
    ....
  21. Consequences and Treatment of Growth Hormone Deficiency in the Metabolic Syndrome
    STEVEN KYLE GRINSPOON; Fiscal Year: 2010
    ..Lay Description: This grant will study how commonly low GH level are seen and contribute to increased cardiac risk in patients with abdominal fat and whether increasing low GH levels will improve cardiac risk in this population. ..
  22. Human Melanocortin-4 Receptor Polymorphisms
    Carrie Haskell Luevano; Fiscal Year: 2007
    ..Understanding obesity related mechanisms may ultimately result in therapeutic agents to prevent or treat the diseases associated with over eating. ..
  23. GABAergic Neurotransmission in PTSD
    Ann Rasmusson; Fiscal Year: 2008
    ..The goal of this research is to identify new neurobiological targets to guide development of improved methods for PTSD treatment and prevention. [unreadable] [unreadable] [unreadable]..