Genomes and Genes
Summary: A naturally occurring dipeptide neuropeptide found in muscles.
Publications257 found, 100 shown here
- Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performanceCraig Sale
School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK
Amino Acids 39:321-33. 2010..b>Carnosine (beta-alanyl-L-histidine) is a cytoplasmic dipeptide found in high concentrations in the skeletal muscle of both ..
- Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacityC A Hill
School of Sports, Exercise and Health Sciences, University of Chichester, Chichester, UK
Amino Acids 32:225-33. 2007Muscle carnosine synthesis is limited by the availability of beta-alanine. Thirteen male subjects were supplemented with beta-alanine (CarnoSyn) for 4 wks, 8 of these for 10 wks...
- beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprintersWim Derave
Dept of Movement and Sport Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
J Appl Physiol (1985) 103:1736-43. 2007b>Carnosine (beta-alanyl-l-histidine) is present in high concentrations in human skeletal muscle. The ingestion of beta-alanine, the rate-limiting precursor of carnosine, has been shown to elevate the muscle carnosine content...
- The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralisR C Harris
School of Sports, Exercise and Health Sciences, University College Chichester, West Sussex, Chichester, UK
Amino Acids 30:279-89. 2006..Concentrations regained baseline at 2 h. Carnosine was not detected in plasma with A) although traces of this and anserine were found in urine...
- Energy metabolism, proteotoxic stress and age-related dysfunction - protection by carnosineAlan R Hipkiss
Aston Research Centre for Healthy Ageing, School of Health and Life Sciences, Aston University, Birmingham B4 7ET, United Kingdom
Mol Aspects Med 32:267-78. 2011..Possible mechanisms by which the endogenous dipeptide, carnosine, which, by way of its putative aldehyde-scavenging activity, may control age-related proteotoxicity, cellular ..
- Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and trainingWim Derave
Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
Sports Med 40:247-63. 2010b>Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle...
- Self-assembly of a peptide amphiphile containing L-carnosine and its mixtures with a multilamellar vesicle forming lipidV Castelletto
School of Chemistry, Food Science and Pharmacy, University of Reading, Whiteknights, Reading, United Kingdom
Langmuir 28:11599-608. 2012..This PA, denoted C(16)-βAH, contains a dipeptide headgroup corresponding to the bioactive molecule L-carnosine. It is found to self-assemble into nanotapes based on stacked layers of molecules...
- Important role of muscle carnosine in rowing performanceAudrey Baguet
Dept of Movement and Sports Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
J Appl Physiol (1985) 109:1096-101. 2010The role of the presence of carnosine (β-alanyl-L-histidine) in millimolar concentrations in human skeletal muscle is poorly understood...
- The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body compositionIain P Kendrick
University of Chichester, College Lane, Chichester, West Sussex PO196PE, UK
Amino Acids 34:547-54. 2008b>Carnosine (Carn) occurs in high concentrations in skeletal muscle is a potent physico-chemical buffer of H+ over the physiological range. Recent research has demonstrated that 6...
- Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse modelChristof Renner
Klinik und Poliklinik fur Neurochirurgie, Universitätsklinikum Leipzig und Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
Mol Cancer 9:2. 2010It was previously demonstrated that the dipeptide carnosine inhibits growth of cultured cells isolated from patients with malignant glioma...
- Carnosine loading and washout in human skeletal musclesAudrey Baguet
Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
J Appl Physiol (1985) 106:837-42. 2009b>Carnosine (beta-alanyl-L-histidine) is present in high concentrations in human skeletal muscles...
- Role of beta-alanine supplementation on muscle carnosine and exercise performanceGuilherme Giannini Artioli
Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, Brazil
Med Sci Sports Exerc 42:1162-73. 2010In this narrative review, we present and discuss the current knowledge available on carnosine and beta-alanine metabolism as well as the effects of beta-alanine supplementation on exercise performance...
- Identification of factors involved in the anti-tumor activity of carnosine on glioblastomas using a proteomics approachAnsgar Asperger
Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Leipzig AoR, 04103 Leipzig, Germany, 1
Cancer Invest 29:272-81. 2011..Recently, it was demonstrated that the dipeptide carnosine inhibits tumor growth, but the main molecular targets are not known...
- Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cellsQiuli Fu
Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058, China
Cell Mol Neurobiol 28:307-16. 20081) The present study was designed to investigate whether histamine is involved in the protective effect of carnosine on Abeta42-induced impairment in differentiated PC12 cells...
- Administration of carnosine in the treatment of acute spinal cord injuryRosanna Di Paola
IRCCS Centro Neurolesi Bonino Pulejo, Via Palermo C da Casazza, 98100 Messina, Italy
Biochem Pharmacol 82:1478-89. 2011L-Carnosine is an endogenously synthesized dipeptide composed of beta-alanine and L-histidine. It acts as a free radical scavenger and possesses antioxidant properties...
- Carnosine as a natural antioxidant and geroprotector: from molecular mechanisms to clinical trialsA A Boldyrev
International Biotechnological Center of MV Lomonosov Moscow State University, Moscow, Russia
Rejuvenation Res 13:156-8. 2010b>Carnosine is a neuroprotective dipeptide consisting of beta-alanine and L-histidine. It demonstrates a number of useful features, including stimulation of brain and muscle microcirculation and a rejuvenating effect on cultured cells...
- Carnosine inhibits KRAS-mediated HCT116 proliferation by affecting ATP and ROS productionBarbara Iovine
Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli Federico II, 80131 Napoli, Italy
Cancer Lett 315:122-8. 2012b>Carnosine is a natural dipeptide that has generated particular interest for its antioxidant, anti-aging and especially for its antiproliferative properties...
- Histidine and carnosine alleviated hepatic steatosis in mice consumed high saturated fat dietMei chin Mong
Department of Health and Nutrition Biotechnology, Asia University, Taichung County, Taiwan, ROC
Eur J Pharmacol 653:82-8. 2011The effects of histidine, alanine and carnosine on activity and/or mRNA expression of lipogenic enzymes and sterol regulatory element-binding proteins (SREBPs) in liver and adipose tissue from high fat diet treated mice were examined...
- L-carnosine inhibits high-glucose-mediated matrix accumulation in human mesangial cells by interfering with TGF-β production and signallingHannes Köppel
15th Medical Clinic, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany
Nephrol Dial Transplant 26:3852-8. 2011..While experimental studies have advanced a protective role of carnosine for diabetic complications, a link between carnosine, TGF-β and matrix accumulation remains to be elucidated...
- Carnosine: new concept for the function of an old moleculeA A Boldyrev
International Biotechnological Center of M V Lomonosov Moscow State University, 119991 Moscow, Russia
Biochemistry (Mosc) 77:313-26. 2012In this review, the development of understanding of the biological functions of carnosine is briefly discussed. Carnosine was first described as a component of meat in 1900 by V. S. Gulevitch...
- Carnosine and its possible roles in nutrition and healthAlan R Hipkiss
School of Clinicial and Experimental Medicine, College of Medical and Dental Sciences, The Univeristy of Birmingham, Edgbaston, Birmingham, UK
Adv Food Nutr Res 57:87-154. 2009The dipeptide carnosine has been observed to exert antiaging activity at cellular and whole animal levels...
- l-carnosine and verapamil inhibit hypoxia-induced expression of hypoxia inducible factor (HIF-1 alpha) in H9c2 cardiomyoblastsLalita A Bharadwaj
Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E5
Pharmacol Res 45:175-81. 2002..We tested l-carnosine, a naturally occurring dipeptide which has been shown to improve myocardial contractility during hypoxia, and ..
- Carnosine and homocarnosine, the forgotten, enigmatic peptides of the brainKarl Bauer
Max Planck Institute for Experimental Endocrinology, Hannover, Germany
Neurochem Res 30:1339-45. 2005b>Carnosine (beta-alanyl-histidine) and homocarnosine (gamma-aminobutyryl-histidine) are major constituents of excitable tissues, brain and skeletal muscles, but their physiological functions are yet unknown...
- The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese ratsGiancarlo Aldini
Department of Pharmaceutical Sciences Pietro Pratesi, Universita degli Studi di Milano, Milan, Italy
J Cell Mol Med 15:1339-54. 2011..This study addresses the effects of chronic administration of the endogenous dipeptide carnosine (β-alanyl-L-histidine, L-CAR) and of its enantiomer (β-alanyl-D-histidine, D-CAR) on hyperlipidaemia, ..
- Carnosine and cancer: a perspectiveFrank Gaunitz
Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Leipzig AoR, 04103, Leipzig, Germany
Amino Acids 43:135-42. 2012The application of carnosine in medicine has been discussed since several years, but many claims of therapeutic effects have not been substantiated by rigorous experimental examination...
- Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic ratsEva Riedl
5th Medical Clinic, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Cell Physiol Biochem 28:279-88. 2011We identified carnosinase-1 (CN-1) as risk-factor for diabetic nephropathy (DN). Carnosine, the substrate for CN-1, supposedly is a protective factor regarding diabetic complications...
- Carnosine, taurine and enzyme activities of human skeletal muscle fibres from elderly subjects with osteoarthritis and young moderately active subjectsMark J Tallon
SSEHS, University of Chichester, Chichester PO19 6PE, UK
Biogerontology 8:129-37. 2007Ageing is associated with a reduction in muscle carnosine (beta-alanyl-L-histidine), but there are no data on the changes specifically in type I and type II muscle fibres...
- Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosineR Holliday
CSIRO Division of Biomolecular Engineering, Sydney Laboratory, NSW, Australia
Br J Cancer 73:966-71. 1996..growth normally in medium containing physiological concentrations of the naturally occurring dipeptide carnosine (beta-alanyl-L-histidine)...
- The effect of 4 weeks beta-alanine supplementation and isokinetic training on carnosine concentrations in type I and II human skeletal muscle fibresIain P Kendrick
University of Chichester, Chichester, UK
Eur J Appl Physiol 106:131-8. 2009..b>Carnosine was measured by HPLC. There was a significant increase in carnosine in both T and UT legs of the beta-ALG (9...
- Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanineJ E Preston
Institute of Gerontology, King s College London, UK
Neurosci Lett 242:105-8. 1998..could be prevented completely at 200 microg/ml A beta and partially at 300 microg/ml A beta, by the dipeptide carnosine. Carnosine is a naturally occurring dipeptide found at high levels in brain tissue and innervated muscle of ..
- Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD miceCarlo Corona
Molecular Neurology Unit, Center of Excellence on Aging Ce S I, University G D Annunzio, Chieti Pescara, Italy
PLoS ONE 6:e17971. 2011..Given these factors, the endogenous peptide carnosine may be potentially beneficial in the treatment of AD because of its free-radical scavenger and metal chelating ..
- Effect of carnosine on excitation-contraction coupling in mechanically-skinned rat skeletal muscleTravis L Dutka
Department of Zoology, La Trobe University, Bundoora, Victoria, 3083, Australia
J Muscle Res Cell Motil 25:203-13. 2004This study investigated whether carnosine alters individual processes involved in normal excitation-contraction (E-C) coupling in mammalian skeletal muscle fibres...
- High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprintingYasuhiro Suzuki
Doctoral Program in Health and Sport Sciences, University of Tsukuba, Japan
Jpn J Physiol 52:199-205. 2002The histidine-containing dipeptide carnosine (beta-alanyl-L-histidine) has been shown to significantly contribute to the physicochemical buffering in skeletal muscles, which maintains acid-base balance when a large quantity of H(+) is ..
- Interactions between carnosine and captopril on free radical scavenging activity and angiotensin-converting enzyme activity in vitroKazuo Nakagawa
Department of Food and Nutrition, Faculty of Home Economics, Kyoto Women s University, Japan
Yakugaku Zasshi 126:37-42. 2006Interactions between carnosine (beta-alanyl-L-histidine), being plentiful in skeletal muscles and neuronal tissues, and captopril, a widely used angiotensin-converting enzyme (ACE) inhibitor, were examined concerning free radical ..
- Decreased formation of advanced glycation end-products in peritoneal fluid by carnosine and related peptidesMohamed Saiel Saeed Alhamdani
Department of Medical Sciences, College of Pharmacy, Al Mustansiriya University, Baghdad, Iraq
Perit Dial Int 27:86-9. 2007..This study aimed to evaluate the effect of carnosine and its related peptides homocarnosine and anserine against the formation of AGEs in PD fluid.
- The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neuronsJin Cheng
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
Eur J Pharmacol 650:184-94. 2011..b>Carnosine exhibited better protection against MDA-induced cell injury than antioxidant N-acetyl-cysteine (NAC) with its ..
- Carnosine inhibits Aβ(42) aggregation by perturbing the H-bond network in and around the central hydrophobic clusterFrancesco Attanasio
Istituto di Biostrutture e Bioimmagini UOS CT, Consiglio Nazionale delle Ricerche, V le A Doria 6, 95125 Catania, Italy
Chembiochem 14:583-92. 2013..Here, we used experimental techniques and atomistic simulations to investigate the influence of carnosine, a dipeptide naturally occurring in the brain, on Aβ aggregation...
- Protective substances against zinc-induced neuronal death after ischemia: carnosine as a target for drug of vascular type of dementiaMasahiro Kawahara
Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714 1 Yoshino cho, Nobeoka City, Miyazaki, 882 8508, Japan
Recent Pat CNS Drug Discov 2:145-9. 2007..Among tested, we found that carnosine (beta-alanyl histidine) protected against zinc-induced death of cultured neurons, and have applied for the ..
- Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humansInge Everaert
Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium
Am J Physiol Renal Physiol 302:F1537-44. 2012A polymorphism in the carnosine dipeptidase-1 gene (CNDP1), resulting in decreased plasma carnosinase activity, is associated with a reduced risk for diabetic nephropathy...
- The roles of carnosine in aging of skeletal muscle and in neuromuscular diseasesH J Stuerenburg
Neurological Department, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
Biochemistry (Mosc) 65:862-5. 2000..The potential significance of carnosine lies on one hand in its possible influence on specific physiological changes in muscle associated with the aging ..
- The effect of carnosine treatment on prooxidant-antioxidant balance in liver, heart and brain tissues of male aged ratsA F Aydin
Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Capa, Istanbul, Turkey
Biogerontology 11:103-9. 2010b>Carnosine (beta-alanyl-L: -histidine) is a dipeptide with antioxidant properties. Oxidative damage by free radicals is one of the mechanisms underlying the aging process...
- Carnosine protects neurons against oxidative stress and modulates the time profile of MAPK cascade signalingKonstantin Kulebyakin
Department of Biochemistry, School of Biology, Room 141, M V Lomonosov Moscow State University, Lenin s Hills, Bldg 1 12, 119992, Moscow, Russia
Amino Acids 43:91-6. 2012b>Carnosine is a known protector of neuronal cells against oxidative injury which prevents both apoptotic and necrotic cellular death. It was shown earlier that carnosine serves as an intracellular buffer of free radicals...
- Effects of L-carnosine on splenic sympathetic nerve activity and tumor proliferationYuko Horii
ANBAS Corporation, 4 12 17, Toyosaki, Kita ku, Osaka 531 0072, Japan
Neurosci Lett 510:1-5. 2012l-Carnosine (β-alanyl-l-histidine), a dipeptide of the amino acids β-alanine and histidine, is found in mammalian tissues including those in the central nervous system and in skeletal muscles...
- Carnosine prevents the glycation-induced changes in electrophoretic mobility of aspartate aminotransferaseN W Seidler
University of Health Sciences, Department of Biochemistry, Kansas City, MO 64106 1453, USA
J Biochem Mol Toxicol 14:215-20. 2000..We also examined the protective effects of carnosine against Glyc3P-induced loss of enzyme activity...
- Carnosine inhibits ATP production in cells from malignant gliomaChristof Renner
Klinik und Poliklinik fur Neurochirurgie, Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
Neurol Res 32:101-5. 2010Recently, it was revealed that carnosine inhibits growth of cells isolated from human malignant glioma...
- Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washoutTrent Stellingwerff
Department of Nutrition and Health, Nestle Research Center, Nestec Ltd, PO Box 44, 1000, Lausanne 26, Switzerland
Amino Acids 42:2461-72. 2012b>Carnosine (β-alanyl-L-histidine) is found in high concentrations in skeletal muscle and chronic β-alanine (BA) supplementation can increase carnosine content...
- Antiglycation effects of carnosine and other compounds on the long-term survival of Escherichia coliEvan D Pepper
Molecular and Computational Biology Section, Ray R Irani Hall RRI 201, University of Southern California, Los Angeles, CA 90089 2910, USA
Appl Environ Microbiol 76:7925-30. 2010..In addition, we have provided evidence that carnosine, folic acid, and aminoguanidine inhibit glycation in prokaryotes...
- Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenalXiaochun Zhu
Departments of Chemistry, Pharmacology, and Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
Chem Res Toxicol 22:1050-9. 2009..ONE is intercepted in biological fluids by antielectrophiles such as glutathione (GSH) or beta-alanylhistidine (carnosine), this would lead to circulating 4-ketoaldehydes that could then bind covalently to the protein Lys residues...
- Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathyFrederick Pfister
5th Medical Department, University Medicine Mannheim, University of Heidelberg, Mannheim, Germany
Cell Physiol Biochem 28:125-36. 2011..In this study, the effect of the antioxidant and antiglycating dipeptide carnosine was studied on the development of experimental diabetic retinopathy.
- Effects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacityAudrey Baguet
Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, Ghent, Belgium
Eur J Appl Physiol 111:2571-80. 2011b>Carnosine is an abundant dipeptide in human skeletal muscle with proton buffering capacity. There is controversy as to whether training can increase muscle carnosine and thereby provide a mechanism for increased buffering capacity...
- Effect of carnosine administration on the immune response of rabbit to Schistosoma mansoni antigensKawther Soliman
Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt
J Egypt Soc Parasitol 33:663-78. 2003..Each of the 3 groups separated eight bands. Carnosine treatment of rabbits immunized with SWAP, CAP or SEA resulted in the disappearance of two bands in SWAP group ..
- Comparison of the carnosine and taurine contents of vastus lateralis of elderly Korean males, with impaired glucose tolerance, and young elite Korean swimmersHyo Jeong Kim
Human Physiology, Korea National Sport University, 88 15 Oryun dong, Songpagu, Seoul, South Korea
Amino Acids 36:359-63. 2009The carnosine and taurine contents of the vastus lateralis of two diverse groups of Korean male subjects (elderly and impaired glucose-tolerant (IGT) subjects and young elite swimmers at a national sport university) having a similar ..
- Carnosine concentration of ingested meat affects carnosine net release into the portal vein of minipigsCaroline Bauchart
UMR1019 Unité de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
J Nutr 137:589-93. 2007Because of its physiological effects, carnosine (beta-alanyl-L-histidine) can be considered as a bioactive food component...
- Determinants of muscle carnosine contentR C Harris
Junipa Ltd, Newmarket, Suffolk, CB8 8HD, UK
Amino Acids 43:5-12. 2012The main determinant of muscle carnosine (M-Carn) content is undoubtedly species, with, for example, aerobically trained female vegetarian athletes [with circa 13 mmol/kg dry muscle (dm)] having just 1/10th of that found in trained ..
- Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)Jakub Drozak
Laboratory of Physiological Chemistry, Universite Catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
J Biol Chem 285:9346-56. 2010b>Carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine) are abundant dipeptides in skeletal muscle and brain of most vertebrates and some invertebrates...
- Quantitation of carnosine in humans plasma after dietary consumption of beefYoung Joon Park
Department of Food Science, Chenoweth Lab, University of Massachusetts, Amherst, Massachusetts 01003, USA
J Agric Food Chem 53:4736-9. 2005b>Carnosine (beta-alanyl-L-histidine) is a dipeptide found in the muscle foods that has been postulated to be a bioactive food component...
- The influence of sex, age and heritability on human skeletal muscle carnosine contentAudrey Baguet
Department of Movement and Sport Sciences, Ghent University, Watersportlaan 2, 9000, Ghent, Belgium
Amino Acids 43:13-20. 2012The dipeptide carnosine is found in high concentrations in human skeletal muscle and shows large inter-individual differences...
- Neuroprotective features of carnosine in oxidative driven diseasesFrancesco Bellia
University of Catania, Department of Chemical Sciences, Viale A Doria 6, 95125 Catania, Italy
Mol Aspects Med 32:258-66. 2011b>Carnosine (β-alanyl-L-histidine) is a natural dipeptide widely and abundantly distributed in excitable tissues of several animal tissues...
- Polaprezinc (Zinc L-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protectionKazuki Ueda
2nd Department of Internal Medicine, Wakayama Medical University, Japan
J Pharmacol Sci 110:285-94. 2009..These data indicate for the first time that PZ is an effective inducer of HO-1 in the stomach. PZ-induced HO-1 functions as a part of the mucosal protective effects of PZ...
- Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitroImran Rashid
Free Radical Group, Heart Research Institute, Sydney, NSW 2050, Australia
FEBS Lett 581:1067-70. 2007..In this study, it is shown that carnosine, or its constituent amino acids beta-alanine and l-histidine, can inhibit the modification of LDL by ..
- Brain type carnosinase in dementia: a pilot studyCynthia M Balion
Department of Laboratory Medicine, Hamilton Health Sciences, Hamilton, Ontario, Canada
BMC Neurol 7:38. 2007..Carnosinase is a dipeptidase found almost exclusively in brain and serum. Carnosinase and its substrate carnosine have been linked to neuropathophysiological processes.
- Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjectsA N Fonteh
Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA 91101 1830, USA
Amino Acids 32:213-24. 2007..methyl-histidine), catecholamines (L-DOPA and dopamine), citrulline, ornithine, glycine and antioxidant DPs (carnosine and anserine) accounted for the major changes between CT and pAD...
- Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosineMasaru Odashima
First Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan
Dig Dis Sci 47:2799-804. 2002An antiulcer drug, zinc L-carnosine (polaprezinc), provides gastric mucosal protection against various irritants...
- Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126Masahiro Kawahara
Department of Analytical Chemistry, School of Pharmaceutical Sciences Kyushu University of Health and Welfare, 1714 1 Yoshino cho, Nobeoka shi, Miyazaki Japan
Metallomics 3:726-34. 2011..b>Carnosine (β-alanyl histidine) significantly inhibited both the β-sheet formation and the neurotoxicity of PrP106-126...
- Metal complexes of carnosineE J Baran
Centro de Quimica Inorganica CEQUINOR CONICET, UNLP, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata, Argentina
Biochemistry (Mosc) 65:789-97. 2000The ligand properties of carnosine are analyzed. The stoichiometry, stability constants, and structural and spectroscopic characteristics of its coordination compounds with transition and representative metal cations are discussed...
- The protective effects of carnosine and melatonin in ischemia-reperfusion injury in the rat liverBasak Baykara
Department of Histology and Embryology, Dokuz Eylul University Medical School, Balcova, Izmir 35340, Turkey
Acta Histochem 111:42-51. 2009..The aim of this study was to investigate the effects of two antioxidant agents, carnosine and melatonin, in rat liver ischemia-reperfusion injury. Five study groups were formed; I. sham, II...
- Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptideG Munch
Theodor Boveri Institute Biocenter, Wurzburg, Germany
Biochim Biophys Acta 1360:17-29. 1997..amyloid peptide aggregates could be attenuated by the AGE-inhibitors Tenilsetam, aminoguanidine and carnosine. These experimental data, and clinical studies, reporting a marked improvement in cognition and memory in ..
- Problems and perspectives in studying the biological role of carnosineA A Boldyrev
International Center for Biotechnology, Department of Biochemistry, Lomonosov Moscow State University, Moscow, 119899, Russia
Biochemistry (Mosc) 65:751-6. 2000In describing carnosine among the constituents of muscle tissue in 1900, V. Gulevitsch opened the question of its real biological role...
- The carnosine content of vastus lateralis is elevated in resistance-trained bodybuildersMark J Tallon
School of Sports, Exercise and Health Sciences, University College Chichester, Chichester, West Sussex, United Kingdom
J Strength Cond Res 19:725-9. 2005..The aim of this study was to investigate the possible adaptive response in muscle carnosine (beta-alanyl-L-histidine) in bodybuilders. Extracts of biopsies of m...
- Interactions between carnosine and zinc and copper: implications for neuromodulation and neuroprotectionP Q Trombley
Biomedical Research Facility, Department of Biological Science, Florida State University, Tallahassee, Florida 32306 4340, USA
Biochemistry (Mosc) 65:807-16. 2000This review examines interactions in the mammalian central nervous system (CNS) between carnosine and the endogenous transition metals zinc and copper...
- Carnosine inhibits degradation of hyaluronan induced by free radical processes in vitro and improves the redox imbalance in adjuvant arthritis in vivoFrantisek Drafi
Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovakia
Neuro Endocrinol Lett 31:96-100. 2010..study we investigated the anti-oxidative and anti-inflammatory properties of the endogenous natural compound carnosine (CARN) in vitro and in vivo...
- Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycationYuan Ti Lee
Department of Internal Medicine, Chungshan Medical University Hospital, Taichung City, Taiwan, ROC
Eur J Pharmacol 513:145-50. 2005In vivo effects of histidine and carnosine against diabetic deterioration in diabetic Balb/cA mice were studied. Histidine and carnosine at 0.5, 1 g/l were added into drinking water...
- Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processesA Mahmood
Department of Gastroenterology, Imperial College London, UK
Gut 56:168-75. 2007Zinc carnosine (ZnC) is a health food product claimed to possess health-promoting and gastrointestinal supportive activity. Scientific evidence underlying these claims is, however, limited.
- Carnosine and protein carbonyl groups: a possible relationshipA R Hipkiss
Division of Biomolecular Sciences, GKT School of Biomedical Sciences, King s College London, London SE1 1UL, UK
Biochemistry (Mosc) 65:771-8. 2000b>Carnosine has been shown to react with low-molecular-weight aldehydes and ketones and has been proposed as a naturally occurring anti-glycating agent...
- Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disordersMichael G Chez
Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake Bluff, IL 60044, USA
J Child Neurol 17:833-7. 2002L-Carnosine, a dipeptide, can enhance frontal lobe function or be neuroprotective. It can also correlate with gamma-aminobutyric acid (GABA)-homocarnosine interaction, with possible anticonvulsive effects...
- Gender-related differences in carnosine, anserine and lysine content of murine skeletal muscleR Penafiel
Department of Biochemistry and Molecular Biology and Department of Pharmacology, Faculty of Medicine, University of Murcia, Murcia, Spain
Amino Acids 26:53-8. 2004The aminoacyl-imidazole dipeptides carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-1-methyl-histidine) are present in relatively high concentrations in excitable tissues, such as muscle and nervous tissue...
- Role of carnosine in preventing thioacetamide-induced liver injury in the ratGüldal Mehmetçik
Near East University, Art and Science Faculty, Lefkosa, KKTC, Turkey
Peptides 29:425-9. 2008b>Carnosine (beta-alanyl-L-histidine) is a dipeptide with antioxidant properties. Free radicals are involved in the pathogenesis of acute liver injury induced by thioacetamide (TAA)...
- Carnosine may reduce lung injury caused by radiation therapyYildiz Guney
Ankara University School of Medicine, Department of Radiation Oncology, Cebeci Hospital, Dikimevi, Turkey
Med Hypotheses 66:957-9. 2006..b>Carnosine is a dipeptide composed by the amino acids beta-histidine and l-alanine...
- Glycyl-histidyl-lysine (GHK) is a quencher of alpha,beta-4-hydroxy-trans-2-nonenal: a comparison with carnosine. insights into the mechanism of reaction by electrospray ionization mass spectrometry, 1H NMR, and computational techniquesGiangiacomo Beretta
Faculty of Pharmacy, Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
Chem Res Toxicol 20:1309-14. 2007..that GHK was an effective quencher of HNE, although significantly less potent than the reference compound carnosine, and that HNE modulation by GHK can contribute to the satisfactory outcome of the wound-healing process...
- Carnosine protects against the inactivation of esterase induced by glycation and a steroidHong Yan
Nuffield Laboratory of Ophthalmology, University of Oxford, Walton St, Oxford OX2 6AW, UK
Biochim Biophys Acta 1741:120-6. 2005b>Carnosine, an endogenous histidine-containing dipeptide, protects protein from oxidation and glycation, which may contribute to a potential treatment for some conformational diseases including cataract...
- Carnosine, the protective, anti-aging peptideA A Boldyrev
Center for Molecular Medicine, Department of Biochemistry, Biological Faculty, MV Lomonosov, Moscow State University, Vorobjovy Gory, Russia
Biosci Rep 19:581-7. 1999b>Carnosine attenuates the development of senile features when used as a supplement to a standard diet of senescence accelerated mice (SAM). Its effect is apparent on physical and behavioral parameters and on average life span...
- The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered ratsB C Artun
Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Hum Exp Toxicol 29:659-65. 2010b>Carnosine is a dipeptide having strong antioxidant effects. Oxidative stress plays an important role in pathogenesis of alcohol-induced liver injury...
- Would carnosine or a carnivorous diet help suppress aging and associated pathologies?Alan R Hipkiss
Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, UK
Ann N Y Acad Sci 1067:369-74. 2006b>Carnosine (beta-alanyl-L-histidine) is found exclusively in animal tissues. Carnosine has the potential to suppress many of the biochemical changes (e.g...
- Carnosine reacts with protein carbonyl groups: another possible role for the anti-ageing peptide?A R Hipkiss
Biomolecular Sciences Division, GKT School of Biomedical Sciences, King s College London, Guy s Campus London Bridge, London EC1 1UL, UK
Biogerontology 1:217-23. 2000b>Carnosine (beta-alanyl-L-histidine) can delay senescence and provoke cellular rejuvenation in cultured human fibroblasts...
- Protective effect of carnosine on subcortical ischemic vascular dementia in miceJing Ma
Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
CNS Neurosci Ther 18:745-53. 2012Recently, we found carnosine protects against N-Methyl-D-Aspartate (NMDA) induced excitotoxicity through a histaminergic pathway...
- Possible role of L-carnosine in the regulation of blood glucose through controlling autonomic nervesKatsuya Nagai
Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
Exp Biol Med (Maywood) 228:1138-45. 2003Mammalian muscles synthesize L-carnosine, but its roles were unknown...
- Anti-aggregating effect of the naturally occurring dipeptide carnosine on aβ1-42 fibril formationAlessandra Aloisi
National Nanotechnology Laboratory of Consiglio Nazionale delle Ricerche, Istituto Nanoscienze Lecce, Lecce, Italy
PLoS ONE 8:e68159. 2013b>Carnosine is an endogenous dipeptide abundant in the central nervous system, where by acting as intracellular pH buffering molecule, Zn/Cu ion chelator, antioxidant and anti-crosslinking agent, it exerts a well-recognized multi-..
- A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophreniaK N Roy Chengappa
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213 2593, USA
Schizophr Res 142:145-52. 2012..We conducted a preliminary study to test the hypothesis that L-carnosine, an antioxidant and anti-glycation agent which is co-localized and released with glutamate would improve ..
- Effects of beta-alanine on muscle carnosine and exercise performance: a review of the current literatureJulie Y Culbertson
Exercise and Sport Nutrition Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77845, USA
Nutrients 2:75-98. 2010Muscle carnosine has been reported to serve as a physiological buffer, possess antioxidant properties, influence enzyme regulation, and affect sarcoplasmic reticulum calcium regulation. Beta-alanine (β-ALA) is a non-essential amino acid...
- [Carnosine, carnosinase and kidney diseases]Katarzyna Kiliś-Pstrusińska
Katedra i Klinika Nefrologii Pediatrycznej Akademii Medycznej we Wrocławiu
Postepy Hig Med Dosw (Online) 66:215-21. 2012b>Carnosine (beta-alanyl-L-histidine) is an endogenously synthesized dipeptide which is present in different human tissues, including the kidney. Carnosine is hydrolyzed by the enzyme carnosinase...
- Detoxification of cytotoxic alpha,beta-unsaturated aldehydes by carnosine: characterization of conjugated adducts by electrospray ionization tandem mass spectrometry and detection by liquid chromatography/mass spectrometry in rat skeletal muscleGiancarlo Aldini
Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
J Mass Spectrom 37:1219-28. 2002..well recognized pathway of detoxification in biological systems, no data are available on HNE interactions with carnosine, a dipeptide (beta-alanyl-L-histidine) present in high concentration in skeletal muscle...
- Effect of carnosine against thioacetamide-induced liver cirrhosis in ratA Fatih Aydin
Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Peptides 31:67-71. 2010b>Carnosine (beta-alanyl-L-histidine) is a dipeptide with antioxidant properties. Oxidative stress has been proposed to be involved in thioacetamide (TAA)-induced liver cirrhosis in rats, that is similar to human disease...
- Protective role of carnosine in mice with cadmium-induced acute hepatotoxicityAmr A Fouad
Department of Biomedical Sciences, Pharmacology Division, College of Medicine, Al Ahsa, King Faisal University, Postal code 31982, Saudi Arabia
Food Chem Toxicol 47:2863-70. 2009The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p...
- Effects of carnosine on contractile apparatus Ca²⁺ sensitivity and sarcoplasmic reticulum Ca²⁺ release in human skeletal muscle fibersT L Dutka
Dept of Zoology, La Trobe Univ, Melbourne 3086, Victoria, Australia
J Appl Physiol (1985) 112:728-36. 2012There is considerable interest in potential ergogenic and therapeutic effects of increasing skeletal muscle carnosine content, although its effects on excitation-contraction (EC) coupling in human muscle have not been defined...
- Beta-alanine (Carnosyn™) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacitySerena Del Favero
School of Physical Education and Sport, University of Sao Paulo, Av Mello de Moraes, 65, Butanta, Sao Paulo, SP, 05508 030, Brazil
Amino Acids 43:49-56. 2012..of this study was to investigate the effects of beta-alanine supplementation on exercise capacity and the muscle carnosine content in elderly subjects...
- Antiglycation and antioxidant effect of carnosine against glucose degradation products in peritoneal mesothelial cellsMohamed Saiel Saeed Alhamdani
Department of Medical Sciences, College of Pharmacy, Al Mustansiriya University Baghdad, Iraq
Nephron Clin Pract 107:c26-34. 2007..The presence of glucose degradation products (GDPs) in PDF is the main cause of its bioincompatibility. Carnosine is an endogenous dipeptide with a powerful antiglycation/antioxidant activity...
- In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosineT Nagasawa
Food and Health Science, Faculty of Agriculture, Iwate University, Morioka, Japan
Mol Cell Biochem 225:29-34. 2001b>Carnosine, a beta-alanyl-L-histidine dipeptide with antioxidant properties is present at high concentrations in skeletal muscle tissue...
- Carnosine inhibits pentylenetetrazol-induced seizures by histaminergic mechanisms in histidine decarboxylase knock-out miceYuan Yuan Zhu
Department of Pharmacology, School of Medicine, Zhejiang University, and Department of Neurology, Second Affiliated Hospital, Hangzhou 310058, China
Neurosci Lett 416:211-6. 2007..both histidine decarboxylase-deficient (HDC-KO) mice and wild-type (WT) mice to elucidate the possible role of carnosine in pentylenetetrazol (PTZ)-induced seizures...
- Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylationI Cacciatore
Dipartimento di Scienze del Farmaco, Universita degli Studi G D Annunzio, 66013 Chieti, Italy
Amino Acids 28:77-83. 2005Three novel carnosine analogues 7-9 containing the residue of L(+)2,3-diaminopropionic acid with different degree of N-acetylation instead of beta-alanine have been synthesized and characterized...
- Carnosine inhibits high glucose-induced mesangial cell proliferation through mediating cell cycle progressionHuijie Jia
Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150081, PR China
Regul Pept 154:69-76. 2009..b>Carnosine is an endogenously synthesized dipeptide that has been reported as a protective factor in diabetic nephropathy...
- Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injuryWen hu Liu
Department of Nutritional Science, Chung Shan Medical University, Taiwan, ROC
Food Chem Toxicol 46:1503-9. 2008Alleviative effects of histidine and carnosine in mice against ethanol-induced oxidative and inflammatory was examined. After chronic alcoholic liver injury was induced, histidine and carnosine at 0...
- Toxicity and Detoxification of 4 Hydroxyalkenals in HeartARUNI BHATNAGAR BHATNAGAR; Fiscal Year: 2013..and the levels of aldehyde-metabolizing enzymes and cellular nucleophiles such as reduced glutathione and carnosine. To identify changes in aldehyde metabolism, metabolites of 4-hydroxy-trans-2-nonenal (HNE) generated in ..
- Exercise, histamine receptors, and vascular functionSteven A Romero; Fiscal Year: 2012..Possible histamine agonists that have been identified include: 1) carnosine released or leaked from skeletal muscle 2) histamine release via mast cell degranulation and 3) de novo ..
- Center for Excellence in Diabetes and Obesity ResearchARUNI BHATNAGAR BHATNAGAR; Fiscal Year: 2013..The five related projects of the junior investigators will: (1) Examine the effects of dietary carnosine on diabetes and obesity;(2) Assess the impact of particulate air pollution on insulin resistance;(3) Elucidate ..
- REGULATION OF B-ALANINE METABOLISMTHOMAS TRAUT; Fiscal Year: 1990..is an amino acid that functions as a neurotransmitter, and also in the biosynthesis of the abundant dipeptides carnosine and anserine in brain and muscle...
- DRUG ABSORPTION VIA THE PEPTIDE TRANSPORTER IN THE EYEVincent Lee; Fiscal Year: 2002..H+-dipeptide transport in the pigmented rabbit cornea and conjunctiva will be measured using 3H-carnosine as a model substrate...
- THE ROLE OF CARNOSINE IN OLFACTIONJoseph Harding; Fiscal Year: 1980A series of proposed experiments are presented which are designed to determine whether or not carnosine may act as a neurotransmitter in the primary olfactory neurons of mice...
- SENSORY NEUROTOXICOLOGY - TOXIC METALS AND OLFACTIONLloyd Hastings; Fiscal Year: 1993..Epithelia and bulbar levels of the putative neurotransmitter/neuromodulator of the olfactory PSN, carnosine, also show little correlation with the functional status of the system after insult...
- Preclinical efficacy and toxicity evaluation of carnosine in strokeArshad Majid; Fiscal Year: 2009..b>Carnosine, a dipeptide, is an endogenous antioxidant and a popular dietary supplement with no known side effects or ..
- DEVELOPMENT OF 1H METABOLITE IMAGING FOR CANCERJiani Hu; Fiscal Year: 2000..nucleotides, DNA and RNA, and the aromatic protons in muscle also include the pH sensitive imidazole proton of carnosine. Preliminary high spatial resolution results have revealed that the putative nucleotide signal in the brain is ..
- Proteomics of Cerebrospinal Fluid in Chronic Fatigue SyndromeJames Baraniuk; Fiscal Year: 2009..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
- NMR Studies of Brain Energetics & Hypoglycemia In VivoKevin Behar; Fiscal Year: 2009....
- Leptin As A Novel Neurohormonal AnticonvulsantKWEE THIO; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- MRI Detection of Skeletal Muscle Microvascular DysfunctionBRUCE DAMON; Fiscal Year: 2007..In these studies we will be developing new methods for studying blood flow to muscles non-invasively. [unreadable] [unreadable] [unreadable]..
- Continuation of the FIND StudyBarry Freedman; Fiscal Year: 2006..of genes that cause diabetic complications will take us one step closer to finding treatments that may have the potential to slow or prevent the development of these serious complications of diabetes mellitus [unreadable] [unreadable]..
- Effects of Antioxidants on Human Macular PigmentsKyung Jin Yeum; Fiscal Year: 2006..unreadable] [unreadable]..
- SYNAPTIC TRANSMISSION IN THE OLFACTORY BULBPAUL TROMBLEY; Fiscal Year: 2003..These experiments should provide a greater understanding of odor information processing by the olfactory bulb and provide clues to the myriad of neuropathological conditions that affect olfactory function. ..
- Quantifying Oxidative Metabolism in Diabetic MuscleBRUCE DAMON; Fiscal Year: 2005..Moreover, these techniques will be suitable for future studies of the effects of exercise training or other interventions in diabetic animal models. ..
- NMR STUDIES OF GABA METABOLISM AND REGULATION IN VIVOKevin Behar; Fiscal Year: 2004....
- Mechanisms of Inhibitory Glycine Receptor ModulationKWEE THIO; Fiscal Year: 2006..abstract_text> ..
- Investigation of Human Muscle Function in vivoBRUCE DAMON; Fiscal Year: 2005..In this application we have requested partial support for the trainees to attend and benefit from the workshop; we have also requested support for a minority trainee travel stipend program...
- GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRDBarry Freedman; Fiscal Year: 2001..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..