carnosine

Summary

Summary: A naturally occurring dipeptide neuropeptide found in muscles.

Top Publications

  1. ncbi Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance
    Craig Sale
    School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK
    Amino Acids 39:321-33. 2010
  2. ncbi Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity
    C A Hill
    School of Sports, Exercise and Health Sciences, University of Chichester, Chichester, UK
    Amino Acids 32:225-33. 2007
  3. ncbi beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters
    Wim Derave
    Dept of Movement and Sport Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
    J Appl Physiol (1985) 103:1736-43. 2007
  4. ncbi The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis
    R C Harris
    School of Sports, Exercise and Health Sciences, University College Chichester, West Sussex, Chichester, UK
    Amino Acids 30:279-89. 2006
  5. ncbi Energy metabolism, proteotoxic stress and age-related dysfunction - protection by carnosine
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing, School of Health and Life Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Mol Aspects Med 32:267-78. 2011
  6. ncbi Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training
    Wim Derave
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    Sports Med 40:247-63. 2010
  7. ncbi Self-assembly of a peptide amphiphile containing L-carnosine and its mixtures with a multilamellar vesicle forming lipid
    V Castelletto
    School of Chemistry, Food Science and Pharmacy, University of Reading, Whiteknights, Reading, United Kingdom
    Langmuir 28:11599-608. 2012
  8. ncbi Important role of muscle carnosine in rowing performance
    Audrey Baguet
    Dept of Movement and Sports Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
    J Appl Physiol (1985) 109:1096-101. 2010
  9. ncbi The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition
    Iain P Kendrick
    University of Chichester, College Lane, Chichester, West Sussex PO196PE, UK
    Amino Acids 34:547-54. 2008
  10. pmc Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model
    Christof Renner
    Klinik und Poliklinik fur Neurochirurgie, Universitätsklinikum Leipzig und Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
    Mol Cancer 9:2. 2010

Research Grants

Detail Information

Publications257 found, 100 shown here

  1. ncbi Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance
    Craig Sale
    School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK
    Amino Acids 39:321-33. 2010
    ..b>Carnosine (beta-alanyl-L-histidine) is a cytoplasmic dipeptide found in high concentrations in the skeletal muscle of both ..
  2. ncbi Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity
    C A Hill
    School of Sports, Exercise and Health Sciences, University of Chichester, Chichester, UK
    Amino Acids 32:225-33. 2007
    Muscle carnosine synthesis is limited by the availability of beta-alanine. Thirteen male subjects were supplemented with beta-alanine (CarnoSyn) for 4 wks, 8 of these for 10 wks...
  3. ncbi beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters
    Wim Derave
    Dept of Movement and Sport Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
    J Appl Physiol (1985) 103:1736-43. 2007
    b>Carnosine (beta-alanyl-l-histidine) is present in high concentrations in human skeletal muscle. The ingestion of beta-alanine, the rate-limiting precursor of carnosine, has been shown to elevate the muscle carnosine content...
  4. ncbi The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis
    R C Harris
    School of Sports, Exercise and Health Sciences, University College Chichester, West Sussex, Chichester, UK
    Amino Acids 30:279-89. 2006
    ..Concentrations regained baseline at 2 h. Carnosine was not detected in plasma with A) although traces of this and anserine were found in urine...
  5. ncbi Energy metabolism, proteotoxic stress and age-related dysfunction - protection by carnosine
    Alan R Hipkiss
    Aston Research Centre for Healthy Ageing, School of Health and Life Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Mol Aspects Med 32:267-78. 2011
    ..Possible mechanisms by which the endogenous dipeptide, carnosine, which, by way of its putative aldehyde-scavenging activity, may control age-related proteotoxicity, cellular ..
  6. ncbi Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training
    Wim Derave
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    Sports Med 40:247-63. 2010
    b>Carnosine is a dipeptide with a high concentration in mammalian skeletal muscle...
  7. ncbi Self-assembly of a peptide amphiphile containing L-carnosine and its mixtures with a multilamellar vesicle forming lipid
    V Castelletto
    School of Chemistry, Food Science and Pharmacy, University of Reading, Whiteknights, Reading, United Kingdom
    Langmuir 28:11599-608. 2012
    ..This PA, denoted C(16)-βAH, contains a dipeptide headgroup corresponding to the bioactive molecule L-carnosine. It is found to self-assemble into nanotapes based on stacked layers of molecules...
  8. ncbi Important role of muscle carnosine in rowing performance
    Audrey Baguet
    Dept of Movement and Sports Sciences, Ghent Univ, Watersportlaan 2, B 9000 Ghent, Belgium
    J Appl Physiol (1985) 109:1096-101. 2010
    The role of the presence of carnosine (β-alanyl-L-histidine) in millimolar concentrations in human skeletal muscle is poorly understood...
  9. ncbi The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition
    Iain P Kendrick
    University of Chichester, College Lane, Chichester, West Sussex PO196PE, UK
    Amino Acids 34:547-54. 2008
    b>Carnosine (Carn) occurs in high concentrations in skeletal muscle is a potent physico-chemical buffer of H+ over the physiological range. Recent research has demonstrated that 6...
  10. pmc Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model
    Christof Renner
    Klinik und Poliklinik fur Neurochirurgie, Universitätsklinikum Leipzig und Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
    Mol Cancer 9:2. 2010
    It was previously demonstrated that the dipeptide carnosine inhibits growth of cultured cells isolated from patients with malignant glioma...
  11. ncbi Carnosine loading and washout in human skeletal muscles
    Audrey Baguet
    Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium
    J Appl Physiol (1985) 106:837-42. 2009
    b>Carnosine (beta-alanyl-L-histidine) is present in high concentrations in human skeletal muscles...
  12. ncbi Role of beta-alanine supplementation on muscle carnosine and exercise performance
    Guilherme Giannini Artioli
    Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, Brazil
    Med Sci Sports Exerc 42:1162-73. 2010
    In this narrative review, we present and discuss the current knowledge available on carnosine and beta-alanine metabolism as well as the effects of beta-alanine supplementation on exercise performance...
  13. ncbi Identification of factors involved in the anti-tumor activity of carnosine on glioblastomas using a proteomics approach
    Ansgar Asperger
    Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Leipzig AoR, 04103 Leipzig, Germany, 1
    Cancer Invest 29:272-81. 2011
    ..Recently, it was demonstrated that the dipeptide carnosine inhibits tumor growth, but the main molecular targets are not known...
  14. ncbi Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells
    Qiuli Fu
    Department of Pharmacology, Institute of Neuroscience, School of Medicine, Zhejiang University, Hangzhou, 310058, China
    Cell Mol Neurobiol 28:307-16. 2008
    1) The present study was designed to investigate whether histamine is involved in the protective effect of carnosine on Abeta42-induced impairment in differentiated PC12 cells...
  15. ncbi Administration of carnosine in the treatment of acute spinal cord injury
    Rosanna Di Paola
    IRCCS Centro Neurolesi Bonino Pulejo, Via Palermo C da Casazza, 98100 Messina, Italy
    Biochem Pharmacol 82:1478-89. 2011
    L-Carnosine is an endogenously synthesized dipeptide composed of beta-alanine and L-histidine. It acts as a free radical scavenger and possesses antioxidant properties...
  16. ncbi Carnosine as a natural antioxidant and geroprotector: from molecular mechanisms to clinical trials
    A A Boldyrev
    International Biotechnological Center of MV Lomonosov Moscow State University, Moscow, Russia
    Rejuvenation Res 13:156-8. 2010
    b>Carnosine is a neuroprotective dipeptide consisting of beta-alanine and L-histidine. It demonstrates a number of useful features, including stimulation of brain and muscle microcirculation and a rejuvenating effect on cultured cells...
  17. ncbi Carnosine inhibits KRAS-mediated HCT116 proliferation by affecting ATP and ROS production
    Barbara Iovine
    Dipartimento di Biochimica e Biotecnologie Mediche, Universita di Napoli Federico II, 80131 Napoli, Italy
    Cancer Lett 315:122-8. 2012
    b>Carnosine is a natural dipeptide that has generated particular interest for its antioxidant, anti-aging and especially for its antiproliferative properties...
  18. ncbi Histidine and carnosine alleviated hepatic steatosis in mice consumed high saturated fat diet
    Mei chin Mong
    Department of Health and Nutrition Biotechnology, Asia University, Taichung County, Taiwan, ROC
    Eur J Pharmacol 653:82-8. 2011
    The effects of histidine, alanine and carnosine on activity and/or mRNA expression of lipogenic enzymes and sterol regulatory element-binding proteins (SREBPs) in liver and adipose tissue from high fat diet treated mice were examined...
  19. ncbi L-carnosine inhibits high-glucose-mediated matrix accumulation in human mesangial cells by interfering with TGF-β production and signalling
    Hannes Köppel
    15th Medical Clinic, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany
    Nephrol Dial Transplant 26:3852-8. 2011
    ..While experimental studies have advanced a protective role of carnosine for diabetic complications, a link between carnosine, TGF-β and matrix accumulation remains to be elucidated...
  20. ncbi Carnosine: new concept for the function of an old molecule
    A A Boldyrev
    International Biotechnological Center of M V Lomonosov Moscow State University, 119991 Moscow, Russia
    Biochemistry (Mosc) 77:313-26. 2012
    In this review, the development of understanding of the biological functions of carnosine is briefly discussed. Carnosine was first described as a component of meat in 1900 by V. S. Gulevitch...
  21. ncbi Carnosine and its possible roles in nutrition and health
    Alan R Hipkiss
    School of Clinicial and Experimental Medicine, College of Medical and Dental Sciences, The Univeristy of Birmingham, Edgbaston, Birmingham, UK
    Adv Food Nutr Res 57:87-154. 2009
    The dipeptide carnosine has been observed to exert antiaging activity at cellular and whole animal levels...
  22. ncbi l-carnosine and verapamil inhibit hypoxia-induced expression of hypoxia inducible factor (HIF-1 alpha) in H9c2 cardiomyoblasts
    Lalita A Bharadwaj
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E5
    Pharmacol Res 45:175-81. 2002
    ..We tested l-carnosine, a naturally occurring dipeptide which has been shown to improve myocardial contractility during hypoxia, and ..
  23. ncbi Carnosine and homocarnosine, the forgotten, enigmatic peptides of the brain
    Karl Bauer
    Max Planck Institute for Experimental Endocrinology, Hannover, Germany
    Neurochem Res 30:1339-45. 2005
    b>Carnosine (beta-alanyl-histidine) and homocarnosine (gamma-aminobutyryl-histidine) are major constituents of excitable tissues, brain and skeletal muscles, but their physiological functions are yet unknown...
  24. ncbi The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats
    Giancarlo Aldini
    Department of Pharmaceutical Sciences Pietro Pratesi, Universita degli Studi di Milano, Milan, Italy
    J Cell Mol Med 15:1339-54. 2011
    ..This study addresses the effects of chronic administration of the endogenous dipeptide carnosine (β-alanyl-L-histidine, L-CAR) and of its enantiomer (β-alanyl-D-histidine, D-CAR) on hyperlipidaemia, ..
  25. ncbi Carnosine and cancer: a perspective
    Frank Gaunitz
    Klinik und Poliklinik fur Neurochirurgie, Universitatsklinikum Leipzig AoR, 04103, Leipzig, Germany
    Amino Acids 43:135-42. 2012
    The application of carnosine in medicine has been discussed since several years, but many claims of therapeutic effects have not been substantiated by rigorous experimental examination...
  26. ncbi Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic rats
    Eva Riedl
    5th Medical Clinic, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Cell Physiol Biochem 28:279-88. 2011
    We identified carnosinase-1 (CN-1) as risk-factor for diabetic nephropathy (DN). Carnosine, the substrate for CN-1, supposedly is a protective factor regarding diabetic complications...
  27. ncbi Carnosine, taurine and enzyme activities of human skeletal muscle fibres from elderly subjects with osteoarthritis and young moderately active subjects
    Mark J Tallon
    SSEHS, University of Chichester, Chichester PO19 6PE, UK
    Biogerontology 8:129-37. 2007
    Ageing is associated with a reduction in muscle carnosine (beta-alanyl-L-histidine), but there are no data on the changes specifically in type I and type II muscle fibres...
  28. pmc Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosine
    R Holliday
    CSIRO Division of Biomolecular Engineering, Sydney Laboratory, NSW, Australia
    Br J Cancer 73:966-71. 1996
    ..growth normally in medium containing physiological concentrations of the naturally occurring dipeptide carnosine (beta-alanyl-L-histidine)...
  29. ncbi The effect of 4 weeks beta-alanine supplementation and isokinetic training on carnosine concentrations in type I and II human skeletal muscle fibres
    Iain P Kendrick
    University of Chichester, Chichester, UK
    Eur J Appl Physiol 106:131-8. 2009
    ..b>Carnosine was measured by HPLC. There was a significant increase in carnosine in both T and UT legs of the beta-ALG (9...
  30. ncbi Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine
    J E Preston
    Institute of Gerontology, King s College London, UK
    Neurosci Lett 242:105-8. 1998
    ..could be prevented completely at 200 microg/ml A beta and partially at 300 microg/ml A beta, by the dipeptide carnosine. Carnosine is a naturally occurring dipeptide found at high levels in brain tissue and innervated muscle of ..
  31. pmc Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice
    Carlo Corona
    Molecular Neurology Unit, Center of Excellence on Aging Ce S I, University G D Annunzio, Chieti Pescara, Italy
    PLoS ONE 6:e17971. 2011
    ..Given these factors, the endogenous peptide carnosine may be potentially beneficial in the treatment of AD because of its free-radical scavenger and metal chelating ..
  32. ncbi Effect of carnosine on excitation-contraction coupling in mechanically-skinned rat skeletal muscle
    Travis L Dutka
    Department of Zoology, La Trobe University, Bundoora, Victoria, 3083, Australia
    J Muscle Res Cell Motil 25:203-13. 2004
    This study investigated whether carnosine alters individual processes involved in normal excitation-contraction (E-C) coupling in mammalian skeletal muscle fibres...
  33. ncbi High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting
    Yasuhiro Suzuki
    Doctoral Program in Health and Sport Sciences, University of Tsukuba, Japan
    Jpn J Physiol 52:199-205. 2002
    The histidine-containing dipeptide carnosine (beta-alanyl-L-histidine) has been shown to significantly contribute to the physicochemical buffering in skeletal muscles, which maintains acid-base balance when a large quantity of H(+) is ..
  34. ncbi Interactions between carnosine and captopril on free radical scavenging activity and angiotensin-converting enzyme activity in vitro
    Kazuo Nakagawa
    Department of Food and Nutrition, Faculty of Home Economics, Kyoto Women s University, Japan
    Yakugaku Zasshi 126:37-42. 2006
    Interactions between carnosine (beta-alanyl-L-histidine), being plentiful in skeletal muscles and neuronal tissues, and captopril, a widely used angiotensin-converting enzyme (ACE) inhibitor, were examined concerning free radical ..
  35. ncbi Decreased formation of advanced glycation end-products in peritoneal fluid by carnosine and related peptides
    Mohamed Saiel Saeed Alhamdani
    Department of Medical Sciences, College of Pharmacy, Al Mustansiriya University, Baghdad, Iraq
    Perit Dial Int 27:86-9. 2007
    ..This study aimed to evaluate the effect of carnosine and its related peptides homocarnosine and anserine against the formation of AGEs in PD fluid.
  36. ncbi The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neurons
    Jin Cheng
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Eur J Pharmacol 650:184-94. 2011
    ..b>Carnosine exhibited better protection against MDA-induced cell injury than antioxidant N-acetyl-cysteine (NAC) with its ..
  37. ncbi Carnosine inhibits Aβ(42) aggregation by perturbing the H-bond network in and around the central hydrophobic cluster
    Francesco Attanasio
    Istituto di Biostrutture e Bioimmagini UOS CT, Consiglio Nazionale delle Ricerche, V le A Doria 6, 95125 Catania, Italy
    Chembiochem 14:583-92. 2013
    ..Here, we used experimental techniques and atomistic simulations to investigate the influence of carnosine, a dipeptide naturally occurring in the brain, on Aβ aggregation...
  38. ncbi Protective substances against zinc-induced neuronal death after ischemia: carnosine as a target for drug of vascular type of dementia
    Masahiro Kawahara
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714 1 Yoshino cho, Nobeoka City, Miyazaki, 882 8508, Japan
    Recent Pat CNS Drug Discov 2:145-9. 2007
    ..Among tested, we found that carnosine (beta-alanyl histidine) protected against zinc-induced death of cultured neurons, and have applied for the ..
  39. ncbi Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans
    Inge Everaert
    Department of Movement and Sport Sciences, Ghent University, Ghent, Belgium
    Am J Physiol Renal Physiol 302:F1537-44. 2012
    A polymorphism in the carnosine dipeptidase-1 gene (CNDP1), resulting in decreased plasma carnosinase activity, is associated with a reduced risk for diabetic nephropathy...
  40. ncbi The roles of carnosine in aging of skeletal muscle and in neuromuscular diseases
    H J Stuerenburg
    Neurological Department, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany
    Biochemistry (Mosc) 65:862-5. 2000
    ..The potential significance of carnosine lies on one hand in its possible influence on specific physiological changes in muscle associated with the aging ..
  41. ncbi The effect of carnosine treatment on prooxidant-antioxidant balance in liver, heart and brain tissues of male aged rats
    A F Aydin
    Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Capa, Istanbul, Turkey
    Biogerontology 11:103-9. 2010
    b>Carnosine (beta-alanyl-L: -histidine) is a dipeptide with antioxidant properties. Oxidative damage by free radicals is one of the mechanisms underlying the aging process...
  42. ncbi Carnosine protects neurons against oxidative stress and modulates the time profile of MAPK cascade signaling
    Konstantin Kulebyakin
    Department of Biochemistry, School of Biology, Room 141, M V Lomonosov Moscow State University, Lenin s Hills, Bldg 1 12, 119992, Moscow, Russia
    Amino Acids 43:91-6. 2012
    b>Carnosine is a known protector of neuronal cells against oxidative injury which prevents both apoptotic and necrotic cellular death. It was shown earlier that carnosine serves as an intracellular buffer of free radicals...
  43. ncbi Effects of L-carnosine on splenic sympathetic nerve activity and tumor proliferation
    Yuko Horii
    ANBAS Corporation, 4 12 17, Toyosaki, Kita ku, Osaka 531 0072, Japan
    Neurosci Lett 510:1-5. 2012
    l-Carnosine (β-alanyl-l-histidine), a dipeptide of the amino acids β-alanine and histidine, is found in mammalian tissues including those in the central nervous system and in skeletal muscles...
  44. ncbi Carnosine prevents the glycation-induced changes in electrophoretic mobility of aspartate aminotransferase
    N W Seidler
    University of Health Sciences, Department of Biochemistry, Kansas City, MO 64106 1453, USA
    J Biochem Mol Toxicol 14:215-20. 2000
    ..We also examined the protective effects of carnosine against Glyc3P-induced loss of enzyme activity...
  45. ncbi Carnosine inhibits ATP production in cells from malignant glioma
    Christof Renner
    Klinik und Poliklinik fur Neurochirurgie, Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
    Neurol Res 32:101-5. 2010
    Recently, it was revealed that carnosine inhibits growth of cells isolated from human malignant glioma...
  46. ncbi Effect of two β-alanine dosing protocols on muscle carnosine synthesis and washout
    Trent Stellingwerff
    Department of Nutrition and Health, Nestle Research Center, Nestec Ltd, PO Box 44, 1000, Lausanne 26, Switzerland
    Amino Acids 42:2461-72. 2012
    b>Carnosine (β-alanyl-L-histidine) is found in high concentrations in skeletal muscle and chronic β-alanine (BA) supplementation can increase carnosine content...
  47. pmc Antiglycation effects of carnosine and other compounds on the long-term survival of Escherichia coli
    Evan D Pepper
    Molecular and Computational Biology Section, Ray R Irani Hall RRI 201, University of Southern California, Los Angeles, CA 90089 2910, USA
    Appl Environ Microbiol 76:7925-30. 2010
    ..In addition, we have provided evidence that carnosine, folic acid, and aminoguanidine inhibit glycation in prokaryotes...
  48. pmc Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal
    Xiaochun Zhu
    Departments of Chemistry, Pharmacology, and Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Chem Res Toxicol 22:1050-9. 2009
    ..ONE is intercepted in biological fluids by antielectrophiles such as glutathione (GSH) or beta-alanylhistidine (carnosine), this would lead to circulating 4-ketoaldehydes that could then bind covalently to the protein Lys residues...
  49. ncbi Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy
    Frederick Pfister
    5th Medical Department, University Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Cell Physiol Biochem 28:125-36. 2011
    ..In this study, the effect of the antioxidant and antiglycating dipeptide carnosine was studied on the development of experimental diabetic retinopathy.
  50. ncbi Effects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacity
    Audrey Baguet
    Department of Movement and Sports Sciences, Ghent University, Watersportlaan 2, Ghent, Belgium
    Eur J Appl Physiol 111:2571-80. 2011
    b>Carnosine is an abundant dipeptide in human skeletal muscle with proton buffering capacity. There is controversy as to whether training can increase muscle carnosine and thereby provide a mechanism for increased buffering capacity...
  51. ncbi Effect of carnosine administration on the immune response of rabbit to Schistosoma mansoni antigens
    Kawther Soliman
    Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt
    J Egypt Soc Parasitol 33:663-78. 2003
    ..Each of the 3 groups separated eight bands. Carnosine treatment of rabbits immunized with SWAP, CAP or SEA resulted in the disappearance of two bands in SWAP group ..
  52. ncbi Comparison of the carnosine and taurine contents of vastus lateralis of elderly Korean males, with impaired glucose tolerance, and young elite Korean swimmers
    Hyo Jeong Kim
    Human Physiology, Korea National Sport University, 88 15 Oryun dong, Songpagu, Seoul, South Korea
    Amino Acids 36:359-63. 2009
    The carnosine and taurine contents of the vastus lateralis of two diverse groups of Korean male subjects (elderly and impaired glucose-tolerant (IGT) subjects and young elite swimmers at a national sport university) having a similar ..
  53. ncbi Carnosine concentration of ingested meat affects carnosine net release into the portal vein of minipigs
    Caroline Bauchart
    UMR1019 Unité de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    J Nutr 137:589-93. 2007
    Because of its physiological effects, carnosine (beta-alanyl-L-histidine) can be considered as a bioactive food component...
  54. pmc Determinants of muscle carnosine content
    R C Harris
    Junipa Ltd, Newmarket, Suffolk, CB8 8HD, UK
    Amino Acids 43:5-12. 2012
    The main determinant of muscle carnosine (M-Carn) content is undoubtedly species, with, for example, aerobically trained female vegetarian athletes [with circa 13 mmol/kg dry muscle (dm)] having just 1/10th of that found in trained ..
  55. pmc Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)
    Jakub Drozak
    Laboratory of Physiological Chemistry, Universite Catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    J Biol Chem 285:9346-56. 2010
    b>Carnosine (beta-alanyl-L-histidine) and homocarnosine (gamma-aminobutyryl-L-histidine) are abundant dipeptides in skeletal muscle and brain of most vertebrates and some invertebrates...
  56. ncbi Quantitation of carnosine in humans plasma after dietary consumption of beef
    Young Joon Park
    Department of Food Science, Chenoweth Lab, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Agric Food Chem 53:4736-9. 2005
    b>Carnosine (beta-alanyl-L-histidine) is a dipeptide found in the muscle foods that has been postulated to be a bioactive food component...
  57. ncbi The influence of sex, age and heritability on human skeletal muscle carnosine content
    Audrey Baguet
    Department of Movement and Sport Sciences, Ghent University, Watersportlaan 2, 9000, Ghent, Belgium
    Amino Acids 43:13-20. 2012
    The dipeptide carnosine is found in high concentrations in human skeletal muscle and shows large inter-individual differences...
  58. ncbi Neuroprotective features of carnosine in oxidative driven diseases
    Francesco Bellia
    University of Catania, Department of Chemical Sciences, Viale A Doria 6, 95125 Catania, Italy
    Mol Aspects Med 32:258-66. 2011
    b>Carnosine (β-alanyl-L-histidine) is a natural dipeptide widely and abundantly distributed in excitable tissues of several animal tissues...
  59. ncbi Polaprezinc (Zinc L-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protection
    Kazuki Ueda
    2nd Department of Internal Medicine, Wakayama Medical University, Japan
    J Pharmacol Sci 110:285-94. 2009
    ..These data indicate for the first time that PZ is an effective inducer of HO-1 in the stomach. PZ-induced HO-1 functions as a part of the mucosal protective effects of PZ...
  60. ncbi Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro
    Imran Rashid
    Free Radical Group, Heart Research Institute, Sydney, NSW 2050, Australia
    FEBS Lett 581:1067-70. 2007
    ..In this study, it is shown that carnosine, or its constituent amino acids beta-alanine and l-histidine, can inhibit the modification of LDL by ..
  61. pmc Brain type carnosinase in dementia: a pilot study
    Cynthia M Balion
    Department of Laboratory Medicine, Hamilton Health Sciences, Hamilton, Ontario, Canada
    BMC Neurol 7:38. 2007
    ..Carnosinase is a dipeptidase found almost exclusively in brain and serum. Carnosinase and its substrate carnosine have been linked to neuropathophysiological processes.
  62. ncbi Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects
    A N Fonteh
    Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA 91101 1830, USA
    Amino Acids 32:213-24. 2007
    ..methyl-histidine), catecholamines (L-DOPA and dopamine), citrulline, ornithine, glycine and antioxidant DPs (carnosine and anserine) accounted for the major changes between CT and pAD...
  63. ncbi Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosine
    Masaru Odashima
    First Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan
    Dig Dis Sci 47:2799-804. 2002
    An antiulcer drug, zinc L-carnosine (polaprezinc), provides gastric mucosal protection against various irritants...
  64. ncbi Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126
    Masahiro Kawahara
    Department of Analytical Chemistry, School of Pharmaceutical Sciences Kyushu University of Health and Welfare, 1714 1 Yoshino cho, Nobeoka shi, Miyazaki Japan
    Metallomics 3:726-34. 2011
    ..b>Carnosine (β-alanyl histidine) significantly inhibited both the β-sheet formation and the neurotoxicity of PrP106-126...
  65. ncbi Metal complexes of carnosine
    E J Baran
    Centro de Quimica Inorganica CEQUINOR CONICET, UNLP, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata, Argentina
    Biochemistry (Mosc) 65:789-97. 2000
    The ligand properties of carnosine are analyzed. The stoichiometry, stability constants, and structural and spectroscopic characteristics of its coordination compounds with transition and representative metal cations are discussed...
  66. ncbi The protective effects of carnosine and melatonin in ischemia-reperfusion injury in the rat liver
    Basak Baykara
    Department of Histology and Embryology, Dokuz Eylul University Medical School, Balcova, Izmir 35340, Turkey
    Acta Histochem 111:42-51. 2009
    ..The aim of this study was to investigate the effects of two antioxidant agents, carnosine and melatonin, in rat liver ischemia-reperfusion injury. Five study groups were formed; I. sham, II...
  67. ncbi Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide
    G Munch
    Theodor Boveri Institute Biocenter, Wurzburg, Germany
    Biochim Biophys Acta 1360:17-29. 1997
    ..amyloid peptide aggregates could be attenuated by the AGE-inhibitors Tenilsetam, aminoguanidine and carnosine. These experimental data, and clinical studies, reporting a marked improvement in cognition and memory in ..
  68. ncbi Problems and perspectives in studying the biological role of carnosine
    A A Boldyrev
    International Center for Biotechnology, Department of Biochemistry, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 65:751-6. 2000
    In describing carnosine among the constituents of muscle tissue in 1900, V. Gulevitsch opened the question of its real biological role...
  69. ncbi The carnosine content of vastus lateralis is elevated in resistance-trained bodybuilders
    Mark J Tallon
    School of Sports, Exercise and Health Sciences, University College Chichester, Chichester, West Sussex, United Kingdom
    J Strength Cond Res 19:725-9. 2005
    ..The aim of this study was to investigate the possible adaptive response in muscle carnosine (beta-alanyl-L-histidine) in bodybuilders. Extracts of biopsies of m...
  70. ncbi Interactions between carnosine and zinc and copper: implications for neuromodulation and neuroprotection
    P Q Trombley
    Biomedical Research Facility, Department of Biological Science, Florida State University, Tallahassee, Florida 32306 4340, USA
    Biochemistry (Mosc) 65:807-16. 2000
    This review examines interactions in the mammalian central nervous system (CNS) between carnosine and the endogenous transition metals zinc and copper...
  71. ncbi Carnosine inhibits degradation of hyaluronan induced by free radical processes in vitro and improves the redox imbalance in adjuvant arthritis in vivo
    Frantisek Drafi
    Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovakia
    Neuro Endocrinol Lett 31:96-100. 2010
    ..study we investigated the anti-oxidative and anti-inflammatory properties of the endogenous natural compound carnosine (CARN) in vitro and in vivo...
  72. ncbi Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation
    Yuan Ti Lee
    Department of Internal Medicine, Chungshan Medical University Hospital, Taichung City, Taiwan, ROC
    Eur J Pharmacol 513:145-50. 2005
    In vivo effects of histidine and carnosine against diabetic deterioration in diabetic Balb/cA mice were studied. Histidine and carnosine at 0.5, 1 g/l were added into drinking water...
  73. pmc Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes
    A Mahmood
    Department of Gastroenterology, Imperial College London, UK
    Gut 56:168-75. 2007
    Zinc carnosine (ZnC) is a health food product claimed to possess health-promoting and gastrointestinal supportive activity. Scientific evidence underlying these claims is, however, limited.
  74. ncbi Carnosine and protein carbonyl groups: a possible relationship
    A R Hipkiss
    Division of Biomolecular Sciences, GKT School of Biomedical Sciences, King s College London, London SE1 1UL, UK
    Biochemistry (Mosc) 65:771-8. 2000
    b>Carnosine has been shown to react with low-molecular-weight aldehydes and ketones and has been proposed as a naturally occurring anti-glycating agent...
  75. ncbi Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders
    Michael G Chez
    Research Division, Autism and Epilepsy Specialty Services of Illinois, Ltd, Lake Bluff, IL 60044, USA
    J Child Neurol 17:833-7. 2002
    L-Carnosine, a dipeptide, can enhance frontal lobe function or be neuroprotective. It can also correlate with gamma-aminobutyric acid (GABA)-homocarnosine interaction, with possible anticonvulsive effects...
  76. ncbi Gender-related differences in carnosine, anserine and lysine content of murine skeletal muscle
    R Penafiel
    Department of Biochemistry and Molecular Biology and Department of Pharmacology, Faculty of Medicine, University of Murcia, Murcia, Spain
    Amino Acids 26:53-8. 2004
    The aminoacyl-imidazole dipeptides carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-1-methyl-histidine) are present in relatively high concentrations in excitable tissues, such as muscle and nervous tissue...
  77. ncbi Role of carnosine in preventing thioacetamide-induced liver injury in the rat
    Güldal Mehmetçik
    Near East University, Art and Science Faculty, Lefkosa, KKTC, Turkey
    Peptides 29:425-9. 2008
    b>Carnosine (beta-alanyl-L-histidine) is a dipeptide with antioxidant properties. Free radicals are involved in the pathogenesis of acute liver injury induced by thioacetamide (TAA)...
  78. ncbi Carnosine may reduce lung injury caused by radiation therapy
    Yildiz Guney
    Ankara University School of Medicine, Department of Radiation Oncology, Cebeci Hospital, Dikimevi, Turkey
    Med Hypotheses 66:957-9. 2006
    ..b>Carnosine is a dipeptide composed by the amino acids beta-histidine and l-alanine...
  79. ncbi Glycyl-histidyl-lysine (GHK) is a quencher of alpha,beta-4-hydroxy-trans-2-nonenal: a comparison with carnosine. insights into the mechanism of reaction by electrospray ionization mass spectrometry, 1H NMR, and computational techniques
    Giangiacomo Beretta
    Faculty of Pharmacy, Istituto di Chimica Farmaceutica e Tossicologica Pietro Pratesi, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
    Chem Res Toxicol 20:1309-14. 2007
    ..that GHK was an effective quencher of HNE, although significantly less potent than the reference compound carnosine, and that HNE modulation by GHK can contribute to the satisfactory outcome of the wound-healing process...
  80. ncbi Carnosine protects against the inactivation of esterase induced by glycation and a steroid
    Hong Yan
    Nuffield Laboratory of Ophthalmology, University of Oxford, Walton St, Oxford OX2 6AW, UK
    Biochim Biophys Acta 1741:120-6. 2005
    b>Carnosine, an endogenous histidine-containing dipeptide, protects protein from oxidation and glycation, which may contribute to a potential treatment for some conformational diseases including cataract...
  81. ncbi Carnosine, the protective, anti-aging peptide
    A A Boldyrev
    Center for Molecular Medicine, Department of Biochemistry, Biological Faculty, MV Lomonosov, Moscow State University, Vorobjovy Gory, Russia
    Biosci Rep 19:581-7. 1999
    b>Carnosine attenuates the development of senile features when used as a supplement to a standard diet of senescence accelerated mice (SAM). Its effect is apparent on physical and behavioral parameters and on average life span...
  82. ncbi The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats
    B C Artun
    Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
    Hum Exp Toxicol 29:659-65. 2010
    b>Carnosine is a dipeptide having strong antioxidant effects. Oxidative stress plays an important role in pathogenesis of alcohol-induced liver injury...
  83. ncbi Would carnosine or a carnivorous diet help suppress aging and associated pathologies?
    Alan R Hipkiss
    Centre for Experimental Therapeutics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, UK
    Ann N Y Acad Sci 1067:369-74. 2006
    b>Carnosine (beta-alanyl-L-histidine) is found exclusively in animal tissues. Carnosine has the potential to suppress many of the biochemical changes (e.g...
  84. ncbi Carnosine reacts with protein carbonyl groups: another possible role for the anti-ageing peptide?
    A R Hipkiss
    Biomolecular Sciences Division, GKT School of Biomedical Sciences, King s College London, Guy s Campus London Bridge, London EC1 1UL, UK
    Biogerontology 1:217-23. 2000
    b>Carnosine (beta-alanyl-L-histidine) can delay senescence and provoke cellular rejuvenation in cultured human fibroblasts...
  85. ncbi Protective effect of carnosine on subcortical ischemic vascular dementia in mice
    Jing Ma
    Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Basic Medical Sciences, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    CNS Neurosci Ther 18:745-53. 2012
    Recently, we found carnosine protects against N-Methyl-D-Aspartate (NMDA) induced excitotoxicity through a histaminergic pathway...
  86. ncbi Possible role of L-carnosine in the regulation of blood glucose through controlling autonomic nerves
    Katsuya Nagai
    Division of Protein Metabolism, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    Exp Biol Med (Maywood) 228:1138-45. 2003
    Mammalian muscles synthesize L-carnosine, but its roles were unknown...
  87. pmc Anti-aggregating effect of the naturally occurring dipeptide carnosine on aβ1-42 fibril formation
    Alessandra Aloisi
    National Nanotechnology Laboratory of Consiglio Nazionale delle Ricerche, Istituto Nanoscienze Lecce, Lecce, Italy
    PLoS ONE 8:e68159. 2013
    b>Carnosine is an endogenous dipeptide abundant in the central nervous system, where by acting as intracellular pH buffering molecule, Zn/Cu ion chelator, antioxidant and anti-crosslinking agent, it exerts a well-recognized multi-..
  88. ncbi A preliminary, randomized, double-blind, placebo-controlled trial of L-carnosine to improve cognition in schizophrenia
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Schizophr Res 142:145-52. 2012
    ..We conducted a preliminary study to test the hypothesis that L-carnosine, an antioxidant and anti-glycation agent which is co-localized and released with glutamate would improve ..
  89. pmc Effects of beta-alanine on muscle carnosine and exercise performance: a review of the current literature
    Julie Y Culbertson
    Exercise and Sport Nutrition Laboratory, Department of Health and Kinesiology, Texas A and M University, College Station, TX 77845, USA
    Nutrients 2:75-98. 2010
    Muscle carnosine has been reported to serve as a physiological buffer, possess antioxidant properties, influence enzyme regulation, and affect sarcoplasmic reticulum calcium regulation. Beta-alanine (β-ALA) is a non-essential amino acid...
  90. ncbi [Carnosine, carnosinase and kidney diseases]
    Katarzyna Kiliś-Pstrusińska
    Katedra i Klinika Nefrologii Pediatrycznej Akademii Medycznej we Wrocławiu
    Postepy Hig Med Dosw (Online) 66:215-21. 2012
    b>Carnosine (beta-alanyl-L-histidine) is an endogenously synthesized dipeptide which is present in different human tissues, including the kidney. Carnosine is hydrolyzed by the enzyme carnosinase...
  91. ncbi Detoxification of cytotoxic alpha,beta-unsaturated aldehydes by carnosine: characterization of conjugated adducts by electrospray ionization tandem mass spectrometry and detection by liquid chromatography/mass spectrometry in rat skeletal muscle
    Giancarlo Aldini
    Istituto Chimico Farmaceutico Tossicologico, University of Milan, Viale Abruzzi 42, 20131 Milan, Italy
    J Mass Spectrom 37:1219-28. 2002
    ..well recognized pathway of detoxification in biological systems, no data are available on HNE interactions with carnosine, a dipeptide (beta-alanyl-L-histidine) present in high concentration in skeletal muscle...
  92. ncbi Effect of carnosine against thioacetamide-induced liver cirrhosis in rat
    A Fatih Aydin
    Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
    Peptides 31:67-71. 2010
    b>Carnosine (beta-alanyl-L-histidine) is a dipeptide with antioxidant properties. Oxidative stress has been proposed to be involved in thioacetamide (TAA)-induced liver cirrhosis in rats, that is similar to human disease...
  93. ncbi Protective role of carnosine in mice with cadmium-induced acute hepatotoxicity
    Amr A Fouad
    Department of Biomedical Sciences, Pharmacology Division, College of Medicine, Al Ahsa, King Faisal University, Postal code 31982, Saudi Arabia
    Food Chem Toxicol 47:2863-70. 2009
    The hepatoprotective effect of carnosine was investigated against cadmium-induced acute liver injury in mice. Hepatotoxicity was induced by a single i.p. injection of cadmium chloride (6.5mg/kg). Carnosine treatment (10mg/kg/day, i.p...
  94. ncbi Effects of carnosine on contractile apparatus Ca²⁺ sensitivity and sarcoplasmic reticulum Ca²⁺ release in human skeletal muscle fibers
    T L Dutka
    Dept of Zoology, La Trobe Univ, Melbourne 3086, Victoria, Australia
    J Appl Physiol (1985) 112:728-36. 2012
    There is considerable interest in potential ergogenic and therapeutic effects of increasing skeletal muscle carnosine content, although its effects on excitation-contraction (EC) coupling in human muscle have not been defined...
  95. pmc Beta-alanine (Carnosyn™) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity
    Serena Del Favero
    School of Physical Education and Sport, University of Sao Paulo, Av Mello de Moraes, 65, Butanta, Sao Paulo, SP, 05508 030, Brazil
    Amino Acids 43:49-56. 2012
    ..of this study was to investigate the effects of beta-alanine supplementation on exercise capacity and the muscle carnosine content in elderly subjects...
  96. ncbi Antiglycation and antioxidant effect of carnosine against glucose degradation products in peritoneal mesothelial cells
    Mohamed Saiel Saeed Alhamdani
    Department of Medical Sciences, College of Pharmacy, Al Mustansiriya University Baghdad, Iraq
    Nephron Clin Pract 107:c26-34. 2007
    ..The presence of glucose degradation products (GDPs) in PDF is the main cause of its bioincompatibility. Carnosine is an endogenous dipeptide with a powerful antiglycation/antioxidant activity...
  97. ncbi In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine
    T Nagasawa
    Food and Health Science, Faculty of Agriculture, Iwate University, Morioka, Japan
    Mol Cell Biochem 225:29-34. 2001
    b>Carnosine, a beta-alanyl-L-histidine dipeptide with antioxidant properties is present at high concentrations in skeletal muscle tissue...
  98. ncbi Carnosine inhibits pentylenetetrazol-induced seizures by histaminergic mechanisms in histidine decarboxylase knock-out mice
    Yuan Yuan Zhu
    Department of Pharmacology, School of Medicine, Zhejiang University, and Department of Neurology, Second Affiliated Hospital, Hangzhou 310058, China
    Neurosci Lett 416:211-6. 2007
    ..both histidine decarboxylase-deficient (HDC-KO) mice and wild-type (WT) mice to elucidate the possible role of carnosine in pentylenetetrazol (PTZ)-induced seizures...
  99. ncbi Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation
    I Cacciatore
    Dipartimento di Scienze del Farmaco, Universita degli Studi G D Annunzio, 66013 Chieti, Italy
    Amino Acids 28:77-83. 2005
    Three novel carnosine analogues 7-9 containing the residue of L(+)2,3-diaminopropionic acid with different degree of N-acetylation instead of beta-alanine have been synthesized and characterized...
  100. ncbi Carnosine inhibits high glucose-induced mesangial cell proliferation through mediating cell cycle progression
    Huijie Jia
    Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin 150081, PR China
    Regul Pept 154:69-76. 2009
    ..b>Carnosine is an endogenously synthesized dipeptide that has been reported as a protective factor in diabetic nephropathy...
  101. ncbi Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injury
    Wen hu Liu
    Department of Nutritional Science, Chung Shan Medical University, Taiwan, ROC
    Food Chem Toxicol 46:1503-9. 2008
    Alleviative effects of histidine and carnosine in mice against ethanol-induced oxidative and inflammatory was examined. After chronic alcoholic liver injury was induced, histidine and carnosine at 0...

Research Grants22

  1. Toxicity and Detoxification of 4 Hydroxyalkenals in Heart
    ARUNI BHATNAGAR BHATNAGAR; Fiscal Year: 2013
    ..and the levels of aldehyde-metabolizing enzymes and cellular nucleophiles such as reduced glutathione and carnosine. To identify changes in aldehyde metabolism, metabolites of 4-hydroxy-trans-2-nonenal (HNE) generated in ..
  2. Exercise, histamine receptors, and vascular function
    Steven A Romero; Fiscal Year: 2012
    ..Possible histamine agonists that have been identified include: 1) carnosine released or leaked from skeletal muscle 2) histamine release via mast cell degranulation and 3) de novo ..
  3. Center for Excellence in Diabetes and Obesity Research
    ARUNI BHATNAGAR BHATNAGAR; Fiscal Year: 2013
    ..The five related projects of the junior investigators will: (1) Examine the effects of dietary carnosine on diabetes and obesity;(2) Assess the impact of particulate air pollution on insulin resistance;(3) Elucidate ..
  4. REGULATION OF B-ALANINE METABOLISM
    THOMAS TRAUT; Fiscal Year: 1990
    ..is an amino acid that functions as a neurotransmitter, and also in the biosynthesis of the abundant dipeptides carnosine and anserine in brain and muscle...
  5. DRUG ABSORPTION VIA THE PEPTIDE TRANSPORTER IN THE EYE
    Vincent Lee; Fiscal Year: 2002
    ..H+-dipeptide transport in the pigmented rabbit cornea and conjunctiva will be measured using 3H-carnosine as a model substrate...
  6. THE ROLE OF CARNOSINE IN OLFACTION
    Joseph Harding; Fiscal Year: 1980
    A series of proposed experiments are presented which are designed to determine whether or not carnosine may act as a neurotransmitter in the primary olfactory neurons of mice...
  7. SENSORY NEUROTOXICOLOGY - TOXIC METALS AND OLFACTION
    Lloyd Hastings; Fiscal Year: 1993
    ..Epithelia and bulbar levels of the putative neurotransmitter/neuromodulator of the olfactory PSN, carnosine, also show little correlation with the functional status of the system after insult...
  8. Preclinical efficacy and toxicity evaluation of carnosine in stroke
    Arshad Majid; Fiscal Year: 2009
    ..b>Carnosine, a dipeptide, is an endogenous antioxidant and a popular dietary supplement with no known side effects or ..
  9. DEVELOPMENT OF 1H METABOLITE IMAGING FOR CANCER
    Jiani Hu; Fiscal Year: 2000
    ..nucleotides, DNA and RNA, and the aromatic protons in muscle also include the pH sensitive imidazole proton of carnosine. Preliminary high spatial resolution results have revealed that the putative nucleotide signal in the brain is ..
  10. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2009
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  11. NMR Studies of Brain Energetics & Hypoglycemia In Vivo
    Kevin Behar; Fiscal Year: 2009
    ....
  12. Leptin As A Novel Neurohormonal Anticonvulsant
    KWEE THIO; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. MRI Detection of Skeletal Muscle Microvascular Dysfunction
    BRUCE DAMON; Fiscal Year: 2007
    ..In these studies we will be developing new methods for studying blood flow to muscles non-invasively. [unreadable] [unreadable] [unreadable]..
  14. Continuation of the FIND Study
    Barry Freedman; Fiscal Year: 2006
    ..of genes that cause diabetic complications will take us one step closer to finding treatments that may have the potential to slow or prevent the development of these serious complications of diabetes mellitus [unreadable] [unreadable]..
  15. Effects of Antioxidants on Human Macular Pigments
    Kyung Jin Yeum; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  16. SYNAPTIC TRANSMISSION IN THE OLFACTORY BULB
    PAUL TROMBLEY; Fiscal Year: 2003
    ..These experiments should provide a greater understanding of odor information processing by the olfactory bulb and provide clues to the myriad of neuropathological conditions that affect olfactory function. ..
  17. Quantifying Oxidative Metabolism in Diabetic Muscle
    BRUCE DAMON; Fiscal Year: 2005
    ..Moreover, these techniques will be suitable for future studies of the effects of exercise training or other interventions in diabetic animal models. ..
  18. NMR STUDIES OF GABA METABOLISM AND REGULATION IN VIVO
    Kevin Behar; Fiscal Year: 2004
    ....
  19. Mechanisms of Inhibitory Glycine Receptor Modulation
    KWEE THIO; Fiscal Year: 2006
    ..abstract_text> ..
  20. Investigation of Human Muscle Function in vivo
    BRUCE DAMON; Fiscal Year: 2005
    ..In this application we have requested partial support for the trainees to attend and benefit from the workshop; we have also requested support for a minority trainee travel stipend program...
  21. GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRD
    Barry Freedman; Fiscal Year: 2001
    ..The identification of hypertension-associated renal failure genes would form a genetic basis for detection of high risk individuals and development of intervention and treatment strategies for prevention of H-ESRD. ..