calcitonin gene related peptide

Summary

Summary: Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.

Top Publications

  1. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
  2. ncbi The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin
    Rui Qing Sun
    Department of Anatomy and Neuroscience, Marine Biomedical Institute, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Pain 104:201-8. 2003
  3. ncbi Vascular actions of calcitonin gene-related peptide and adrenomedullin
    Susan D Brain
    Centre for Cardiovascular Biology and Medicine, King s College London, Guy s Campus, London SE1 1UL, UK
    Physiol Rev 84:903-34. 2004
  4. ncbi Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance p-containing afferents and respond to noxious stimulation
    Andrew J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 22:4103-13. 2002
  5. pmc The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions
    Stephen G Howitt
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET
    Br J Pharmacol 138:325-32. 2003
  6. pmc Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat
    L Delafoy
    Pfizer Global Research and Development, Fresnes Laboratories, France
    Gut 55:940-5. 2006
  7. ncbi [A study of the different effect on the expression of calcitonin gene related peptide and neuropeptide Y in tissue engineered bone with vascular bundle graft in vivo and that with sensory nerve tract graft in vivo]
    Jian de Cui
    Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou 510515, China
    Zhonghua Wai Ke Za Zhi 46:1249-52. 2008
  8. ncbi A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas
    P Westermark
    Biochem Biophys Res Commun 140:827-31. 1986
  9. ncbi Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    P M Zygmunt
    Department of Clinical Pharmacology, Institute of Laboratory Medicine, University of Lund, Sweden
    Nature 400:452-7. 1999
  10. ncbi A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors
    Alex C Conner
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Mol Pharmacol 67:20-31. 2005

Detail Information

Publications293 found, 100 shown here

  1. ncbi RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
    L M McLatchie
    Receptor Systems and Cell Biology Units, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, UK
    Nature 393:333-9. 1998
    ..RAMP1 presents the receptor at the cell surface as a mature glycoprotein and a CGRP receptor. RAMP2-transported receptors are core-glycosylated and are adrenomedullin receptors...
  2. ncbi The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin
    Rui Qing Sun
    Department of Anatomy and Neuroscience, Marine Biomedical Institute, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Pain 104:201-8. 2003
    ..Collectively, these results suggest that CGRP receptors present in the dorsal horn are involved in the generation and maintenance of nociceptive behaviors associated with cutaneous inflammation...
  3. ncbi Vascular actions of calcitonin gene-related peptide and adrenomedullin
    Susan D Brain
    Centre for Cardiovascular Biology and Medicine, King s College London, Guy s Campus, London SE1 1UL, UK
    Physiol Rev 84:903-34. 2004
    ..The cardiovascular activity of these peptides in a range of species and in human clinical conditions is detailed, and potential therapeutic applications based on use of antagonists and gene targeting of agonists are discussed...
  4. ncbi Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance p-containing afferents and respond to noxious stimulation
    Andrew J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 22:4103-13. 2002
    ..We conclude that presence or absence of the NK1 receptor is a better indicator of function than morphology for lamina I projection neurons in the rat...
  5. pmc The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions
    Stephen G Howitt
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET
    Br J Pharmacol 138:325-32. 2003
    ..Leu(16) is in a conformationally restricted site when CGRP(8-37) binds to CGRP(1) receptors, unlike Leu(12) and Leu(15)...
  6. pmc Interactive involvement of brain derived neurotrophic factor, nerve growth factor, and calcitonin gene related peptide in colonic hypersensitivity in the rat
    L Delafoy
    Pfizer Global Research and Development, Fresnes Laboratories, France
    Gut 55:940-5. 2006
    ..Based on data on brain derived neurotrophic factor (BDNF) and calcitonin gene related peptide (CGRP) in pain, the aims of the present study were: (1) to investigate the involvement of BDNF and ..
  7. ncbi [A study of the different effect on the expression of calcitonin gene related peptide and neuropeptide Y in tissue engineered bone with vascular bundle graft in vivo and that with sensory nerve tract graft in vivo]
    Jian de Cui
    Department of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou 510515, China
    Zhonghua Wai Ke Za Zhi 46:1249-52. 2008
    To evaluate the different effect on the expression of Calcitonin gene related peptide (CGRP)and neuropeptide Y (NPY) between tissue engineered bone with vascular bundle graft in vivo and that with sensory nerve tract graft in vivo.
  8. ncbi A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas
    P Westermark
    Biochem Biophys Res Commun 140:827-31. 1986
    ..N-terminal amino acid sequence of the protein is unique and does not resemble insulin or its precursors. Instead it has about 50% homology with the neuropeptide CGRP (calcitonin gene related peptide).
  9. ncbi Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    P M Zygmunt
    Department of Clinical Pharmacology, Institute of Laboratory Medicine, University of Lund, Sweden
    Nature 400:452-7. 1999
    ..The vanilloid receptor may thus be another molecular target for endogenous anandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems...
  10. ncbi A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors
    Alex C Conner
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Mol Pharmacol 67:20-31. 2005
    ..P321A-I325P, predicted to restore this conformation, showed wild-type activation. Modeling can also rationalize the effects of transmembrane proline mutants previously reported for another family B GPCR, the VPAC(1) receptor...
  11. pmc Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide
    Masaya Toda
    Departments of Pharmacology and Anesthesiology, Kitasato University School of Medicine, Kanagawa 228 8555, Japan
    Proc Natl Acad Sci U S A 105:13550-5. 2008
    ....
  12. ncbi Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1
    M Trevisani
    Department of Experimental and Clinical Medicine, Headache Center, University of Ferrara, via Fossato di Mortara 19, 44100 Ferrara, Italy
    Nat Neurosci 5:546-51. 2002
    ..This provides a likely mechanistic explanation for the ethanol-induced sensory responses that occur at body temperature and for the sensitivity of inflamed tissues to ethanol, such as might be found in esophagitis, neuralgia or wounds...
  13. ncbi Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice
    A M Salmon
    CNRS URA 2182, Neurobiologie moleculaire, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Nat Neurosci 4:357-8. 2001
    ....
  14. ncbi CGRP antagonists: unravelling the role of CGRP in migraine
    Henri Doods
    Boehringer Ingelheim Pharma GmbH and Co KG, 88397 Biberach, Germany
    Trends Pharmacol Sci 28:580-7. 2007
    ..Moreover, the recently published results from Phase II trials are encouraging and suggest that this new type of drug might offer advantages over existing therapies for patients suffering from migraine and related headaches...
  15. pmc Neuron-glia signaling in trigeminal ganglion: implications for migraine pathology
    Srikanth Thalakoti
    Department of Biology, Missouri State University, Springfield, MO 65897, USA
    Headache 47:1008-23; discussion 24-5. 2007
    ..The goal of this study was to investigate neuronal-glial cell signaling in trigeminal ganglia under basal and inflammatory conditions using an in vivo model of trigeminal nerve activation...
  16. ncbi Nitric oxide metabolites, prostaglandins and trigeminal vasoactive peptides in internal jugular vein blood during spontaneous migraine attacks
    P Sarchielli
    Interuniversity Centre for the Study of Headache and Neurotransmitter Disorders, University of Perugia, Italy
    Cephalalgia 20:907-18. 2000
    ....
  17. ncbi Calcitonin gene related peptide mediates cardioprotection by remote preconditioning
    Sebastian Wolfrum
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Regul Pept 127:217-24. 2005
    ..Since calcitonin gene related peptide (CGRP) is an important mediator of sensory neurons we tried to delineate whether CGRP a) protects the ..
  18. ncbi A cDNA encoding the calcitonin gene-related peptide type 1 receptor
    N Aiyar
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 271:11325-9. 1996
    ..Exposure of these cells to CGRP resulted in a 60-fold increase in cAMP production, which was inhibited in a competitive manner by the CGRP1 receptor antagonist, CGRP-(8-37)...
  19. ncbi Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine
    Dan Levy
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 58:698-705. 2005
    ..The results of this study suggest that CGRP effects in the meninges, including meningeal vasodilatation, are not sufficient to activate or sensitize meningeal nociceptors...
  20. ncbi Substance P, calcitonin gene related peptide and PGE2 co-released from the mouse colon: a new model to study nociceptive and inflammatory responses in viscera, in vitro
    C Roza
    Department of Physiology and Experimental Pathophysiology, University of Erlangen-Nuremberg, , D-91054, Erlangen, Germany
    Pain 93:213-9. 2001
    ..Capsaicin, heat and pH 5.2 were able to induce significant increases in calcitonin gene related peptide (CGRP) release (14.6-, 5.1-, and 2...
  21. ncbi Localization and modulation of calcitonin gene-related peptide-receptor component protein-immunoreactive cells in the rat central and peripheral nervous systems
    W Ma
    Douglas Hospital Research Center, McGill University, Montreal, Quebec, Canada H4H 1R3
    Neuroscience 120:677-94. 2003
    ..Moreover, our data also suggest that RCP expression in DRG and spinal cord can be modulated during CGRP receptor blockade, inflammation or neuropathic pain and this CGRP receptor-associated protein is dynamically regulated...
  22. ncbi Calcitonin gene-related peptide protects against hypertension-induced heart and kidney damage
    Scott C Supowit
    Texas A and M University System Health Science Center, Temple, TX, USA
    Hypertension 45:109-14. 2005
    ..These data suggest that deletion of the alpha-calcitonin gene-related peptide gene makes the heart and kidneys more vulnerable to hypertension-induced end organ damage...
  23. ncbi Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from rat trigeminal ganglion: evidence for intraganglionic neurotransmission
    Y M Ulrich-Lai
    Department of Restorative Sciences, University of Minnesota, Box 120 UMHC, 516 Delaware St. SE, Minneapolis, MN 55455, USA
    Pain 91:219-26. 2001
    ..These data support the hypothesis that Ca(2+)-dependent exocytosis of neuropeptides may occur within the TGG in vivo and that the majority of this release derives from neuronal somata...
  24. ncbi Effects of the vasoactive neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal polypeptide on skin temperature in ovariectomized rats
    M Noguchi
    Tsumura Research Institute Medicinal Evaluation Laboratory, 3586 Yoshiwara, Ami Machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Neuropeptides 36:327-32. 2002
    ..These results suggest not only that CGRP is closely related to the elevation of skin temperature but also that CGRP-induced responses are more affected by ovarian hormone deficiency...
  25. pmc Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine
    Gregory O Dussor
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX, USA
    Eur J Neurosci 18:2515-26. 2003
    ..In the case of users of nicotine-containing tobacco products, this modulation could contribute to inflammatory processes within the oral cavity...
  26. ncbi Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin
    S Hilairet
    Departement de Biochimie, Universite de Montreal, Montreal, Quebec, H3C 3J7, Canada
    J Biol Chem 276:42182-90. 2001
    ..These results therefore indicate that although atypical by its heterodimeric composition and its targeting to the plasma membrane, the CGRP receptor shares endocytotic mechanisms that are common to most classical 7TM receptors...
  27. ncbi Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics
    A L Breeze
    Department of Biochemistry, University of Oxford, U K
    Biochemistry 30:575-82. 1991
    ..Comparison of spectra for the homologous hCGRP-2 with those of hCGRP-1 indicates that the conformations of these two forms are essentially identical...
  28. ncbi Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum
    Seigo Fujimoto
    Department of Cellular and Molecular Pharmacology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho cho, Mizuho ku, Japan
    Eur J Pharmacol 530:144-51. 2006
    ..The relaxation could be explained by a decrease in phosphorylation of MLC(20)...
  29. ncbi Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and neutrophils
    Guillaume Monneret
    Immunology Laboratory and Intensive Care Unit, Lyon Sud University Hospital, 69495, Pierre Benite, France
    Intensive Care Med 29:923-8. 2003
    Circulating levels of calcitonin gene related peptide (CGRP) and calcitonin precursors, including procalcitonin (PCT) and its free aminopeptide N-procalcitonin (N-PCT), have been found dramatically increased in septic patients...
  30. ncbi Substance P and calcitonin gene related peptide induce TGF-alpha expression in epithelial cells via mast cells and fibroblasts
    Peter Hoffmann
    Department of Internal Medicine I, Kliniken Essen Mitte, Essen, Germany
    Regul Pept 161:33-7. 2010
    ....
  31. pmc Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse
    Theodore J Price
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio San Antonio, TX, USA
    J Pain 8:263-72. 2007
    ..Thus, whereas only an approximately 10% overlap was observed in TG neurons of mouse, significantly greater overlap (approximately 35%) was observed in those of rat...
  32. ncbi Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor
    Manja Lang
    Institute of Biochemistry, University of Leipzig, D 04103 Leipzig, Germany
    J Med Chem 49:616-24. 2006
    b>Calcitonin gene related peptide (CGRP) plays an important role in the CNS and in the cardiovascular system...
  33. pmc Vanilloid type 1 receptors (VR1) on trigeminal sensory nerve fibres play a minor role in neurogenic dural vasodilatation, and are involved in capsaicin-induced dural dilation
    S Akerman
    Headache Group, Institute of Neurology, Queen Square, London WCIN 3BG
    Br J Pharmacol 140:718-24. 2003
    ..The data imply that the VR1 receptor plays only a minor role in trigeminovascular-induced dural vessel dilation...
  34. ncbi Migraine as an inflammatory disorder
    Christian Waeber
    Radiology Department, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neurology 64:S9-15. 2005
  35. pmc Calcitonin gene related peptide and neuropeptide Y in skeletal muscle after eccentric exercise: a microdialysis study
    S Jonhagen
    Karolinska Institutet, Sodersjukhuset, Stockholm, Sweden
    Br J Sports Med 40:264-7; discussion 264-7. 2006
    ..To detect neuropeptides in human skeletal muscle at rest and after eccentric exercise...
  36. pmc Pharmacological evidence for CGRP uptake into perivascular capsaicin sensitive nerve terminals
    A Sams-Nielsen
    Department of Pharmacology, The Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100 Copenhagen Ø, Denmark
    Br J Pharmacol 132:1145-53. 2001
    ..Immunohistochemical experiments showed that only terminal CGRP is subject to capsaicin-induced depletion in vitro, whereas CGRP-immunoreactivity endures in the nerve fibres...
  37. ncbi Flurbiprofen inhibits capsaicin induced calcitonin gene related peptide release from rat spinal cord via an endocannabinoid dependent mechanism
    Kay Seidel
    Department of Experimental and Clinical Pharmacology and Toxicology, University Erlangen Nürnberg Fahrstrasse 17, D 91054, Erlangen, Germany
    Neurosci Lett 338:99-102. 2003
    b>Calcitonin gene related peptide (CGRP) is involved in nociceptive transmission and modulation at the spinal level...
  38. ncbi Effects of spinal nerve ligation on immunohistochemically identified neurons in the L4 and L5 dorsal root ganglia of the rat
    Donna L Hammond
    Department of Anesthesia, The University of Iowa, Iowa City, Iowa 52242, USA
    J Comp Neurol 475:575-89. 2004
    ..Unlike the L5 DRG, injury-induced changes in the expression of various receptors, neurotransmitters and neurotrophic factors in the L4 DRG are not confounded by a change in the immunohistochemical phenotype of primary afferent neurons...
  39. ncbi Stimulation of the calcitonin gene-related peptide enhancer by mitogen-activated protein kinases and repression by an antimigraine drug in trigeminal ganglia neurons
    Paul L Durham
    Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 23:807-15. 2003
    ..We propose that activation of MAPK pathways may increase CGRP gene expression during migraine, and that sumatriptan can diametrically oppose that activation via a prolonged elevation of intracellular calcium...
  40. ncbi Calcitonin gene-related peptide 8-37 inhibits the evoked discharge frequency of wide dynamic range neurons in dorsal horn of the spinal cord in rats
    L C Yu
    Department of Physiology, College of Life Science, Peking University, Beijing, People s Republic of China
    Regul Pept 83:21-4. 1999
    ..The results indicate that CGRP receptors play an important role in the transmission of presumed nociceptive information in the dorsal horn of the spinal cord...
  41. pmc Nitric oxide regulation of calcitonin gene-related peptide gene expression in rat trigeminal ganglia neurons
    Jamie Bellamy
    Department of Biology, 225 Temple Hall, Missouri State University, Springfield, MO 65897, USA
    Eur J Neurosci 23:2057-66. 2006
    ..In summary, our results provide new insight into the cellular mechanisms by which nitric oxide induces CGRP synthesis and secretion from trigeminal neurons...
  42. ncbi Undescended testis is accompanied by calcitonin gene related peptide accumulation within the sensory nucleus of the genitofemoral nerve in trans-scrotal rats
    Z Hrabovszky
    F. Douglas Stephens Surgical Research Laboratory, Royal Children's Hospital Research Institute, Melbourne, Australia
    J Urol 165:1015-8. 2001
    PURPOSE: Recent data suggest that calcitonin gene related peptide (CGRP) released from the sensory branch of the genitofemoral nerve may regulate testicular descent...
  43. pmc Involvement of calcitonin gene-related peptide in migraine: regional cerebral blood flow and blood flow velocity in migraine patients
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    J Headache Pain 9:151-7. 2008
    ..005) and an increase in heart rate (58%) (P < 0.0001). CGRP dilates cerebral arteries, but the effect is so small that it is unlikely to be the only mechanism of CGRP-induced migraine...
  44. ncbi Structure and expression of a gene encoding human calcitonin and calcitonin gene related peptide
    B D Nelkin
    Biochem Biophys Res Commun 123:648-55. 1984
    Messenger RNAs for calcitonin (CT) and calcitonin gene related peptide (CGRP) have been detected in a human medullary thyroid carcinoma cell line...
  45. ncbi Spinal G-protein-gated potassium channels contribute in a dose-dependent manner to the analgesic effect of mu- and delta- but not kappa-opioids
    Cheryl L Marker
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 25:3551-9. 2005
    ....
  46. ncbi Regulation of inflammatory responses by sensory neurons: molecular mechanism(s) and possible therapeutic applications
    Kenji Okajima
    Department of Biodefense Medicine, Nagoya City University Graduate School of Medical Sciences, Japan
    Curr Med Chem 13:2241-51. 2006
    ....
  47. ncbi Levels of nerve growth factor in cerebrospinal fluid of chronic daily headache patients
    P Sarchielli
    Department of Neuroscience, University of Perugia, Italy
    Neurology 57:132-4. 2001
    ..There was a significant positive correlation between NGF and both SP and CGRP values. These findings suggest that NGF is involved in the long-lasting sensitization and sustained activation of the trigeminal system in CDH...
  48. ncbi Colocalization of CGRP with 5-HT1B/1D receptors and substance P in trigeminal ganglion neurons in rats
    Q P Ma
    Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow CM20 2QR, UK
    Eur J Neurosci 13:2099-104. 2001
    ..These results support the hypothesis that one important action of antimigraine drugs is the inhibition of CGRP release and that Adelta-fibres may play an important role in migraine pathogenesis...
  49. ncbi Plasma levels of calcitonin gene-related peptide in chronic tension-type headache
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Neurology 55:1335-40. 2000
    ..Calcitonin gene-related peptide (CGRP) is involved in the pathophysiology of migraine and cluster headache. Whether CGRP has any role in chronic tension-type headache is unknown...
  50. ncbi The role of nitric oxide (NO) in migraine, tension-type headache and cluster headache
    Jes Olesen
    University of Copenhagen, Department of Neurology, Glostrup Hospital, Ndr Ringvej 57, DK 2600 Glostrup, Copenhagen, Denmark
    Pharmacol Ther 120:157-71. 2008
    ..Indeed, selective n-NOS and i-NOS inhibitors are already in early clinical development...
  51. ncbi Somatosensory organization and behavior in naked mole-rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain
    Thomas J Park
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Comp Neurol 465:104-20. 2003
    ..The features of this mammalian model system provide unique opportunities to discriminate mechanisms related to tactile spatial orientation, vascular regulation, and nociception...
  52. ncbi Calcitonin gene-related peptide (CGRP) antagonists and migraine: is this a new era?
    Peter J Goadsby
    Neurology 70:1300-1. 2008
  53. ncbi Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse
    Melissa Zwick
    Department of Anatomy, University of Kentucky School of Medicine, Lexington, Kentucky 40536, USA
    J Neurosci 22:4057-65. 2002
    ....
  54. pmc Treatment of migraine attacks based on the interaction with the trigemino-cerebrovascular system
    Andrea Stephanie Link
    Biomedical Center Lund, Lund, Sweden
    J Headache Pain 9:5-12. 2008
    ..The purpose of this review is to give a short overview of the pathological background of migraine headache and to illustrate the mechanisms behind the actions of triptans and the promising CGRP receptor blockers...
  55. ncbi Ethanol causes inflammation in the airways by a neurogenic and TRPV1-dependent mechanism
    Marcello Trevisani
    Center of Excellence for the Study of Inflammation, University of Ferrara, 44100 Ferrara, Italy
    J Pharmacol Exp Ther 309:1167-73. 2004
    ..This excitatory effect of EtOH, distinct from that of AcH, results in neurogenic inflammatory responses that may contribute to the mechanism of EtOH-induced asthma...
  56. ncbi Nociceptin (1-13)NH2 inhibits stimulated calcitonin-gene-related-peptide release from primary cultures of rat trigeminal ganglia neurones
    A Capuano
    Department of Neuroscience and Institute of Pharmacology, Catholic University Medical School, Rome, Italy
    Cephalalgia 27:868-76. 2007
    ....
  57. ncbi Calcitonin gene-related peptide receptor activation produces PKA- and PKC-dependent mechanical hyperalgesia and central sensitization
    Rui Qing Sun
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 1069, USA
    J Neurophysiol 92:2859-66. 2004
    ....
  58. pmc Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene-related peptide induced dilation of dural meningeal vessels
    S Akerman
    Headache Group, Institute of Neurology, Queen Square, London WC1N 3BG
    Br J Pharmacol 137:62-8. 2002
    ..8. Further, eNOS activity in the endothelium causes NO production and smooth muscle relaxation by direct activation of the NO-cGMP pathway, and may be involved in the initial headache response...
  59. ncbi Calcitonin gene-related peptide and its role in migraine pathophysiology
    Udayasankar Arulmani
    Department of Pharmacology, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Centre Rotterdam, P O Box 1738, Rotterdam 3000 DR, The Netherlands
    Eur J Pharmacol 500:315-30. 2004
    ..The present review will discuss mainly the potential role of CGRP in the pathophysiology of migraine and the various treatment modalities that are currently available to target this neuropeptide...
  60. ncbi Forearm vascular response to nitric oxide and calcitonin gene-related peptide: comparison between migraine patients and control subjects
    J N J M de Hoon
    Centre for Clinical Pharmacology, University Hospital Gasthuisberg K U Leuven, Leuven, Belgium
    Cephalalgia 26:56-63. 2006
    ..FMD was comparable in control subjects (5.8 +/- 1%) and migraine patients (5.2 +/- 1%). Based on the forearm vascular response to NO and CGRP, migraine patients do not display generalized changes in vascular function...
  61. ncbi Neurogenic inflammation and migraine: implications for the therapeutics
    Stephen J Peroutka
    Synergia Pharma, Inc, 601 Gateway Boulevard, Suite 350, South San Francisco, CA 94080, USA
    Mol Interv 5:304-11. 2005
    ..e., PPE and NV) in migraine pathophysiology. The data indicate that the PPE component of NI plays no significant role in migraine but that NV is likely to be involved in migraine pathophysiology...
  62. ncbi NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release
    Gabriella Juhasz
    Laboratory of Neurochemistry and Experimental Medicine, Department of Vascular Neurology, Faculty of Medicine, Semmelweis University, National Institute of Psychiatry and Neurology, Huvosvolgyi ut 116, Budapest, H 1021, Hungary
    Pain 106:461-70. 2003
    ..In contrast, serotonin release from platelets does not provoke migraine, it may even counteract the headache and the concomitant CGRP release in this model...
  63. ncbi Role of calcitonin gene-related peptide in the sensitization of dorsal horn neurons to mechanical stimulation after intradermal injection of capsaicin
    Rui Qing Sun
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 92:320-6. 2004
    ..The effect could be blocked by CGRP(8-37) dose-dependently. Collectively, these results suggest that CGRP and its receptors are involved in the spinal cord central sensitization induced by intradermal injection of capsaicin...
  64. ncbi CGRP-receptor antagonists--a fresh approach to migraine therapy?
    Paul L Durham
    Department of Biology, Southwest Missouri State University, Springfield, USA
    N Engl J Med 350:1073-5. 2004
  65. ncbi Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat
    K R Oliver
    Merck Research Laboratories, Neuroscience Research Centre, Harlow, Essex CM20 QR, UK
    Eur J Neurosci 14:618-28. 2001
    ..Furthermore, these localization data suggest that the RAMP family may associate and modify the behaviour of other, as yet unidentified neurotransmitter receptors...
  66. ncbi Recent advances in understanding migraine mechanisms, molecules and therapeutics
    Peter J Goadsby
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Trends Mol Med 13:39-44. 2007
    ..These data lead to the view that migraine is a form of sensory dysmodulatio--a system failure of normal sensory processing...
  67. ncbi Evidence for increased plasma levels of calcitonin gene-related peptide in migraine outside of attacks
    M Ashina
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Denmark
    Pain 86:133-8. 2000
    ..It is hypothesized that this finding may reflect a long-lasting or permanent abnormal neurogenic vascular control in patients with migraine...
  68. pmc The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons
    Andreas Leffler
    Department of Anesthesiology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    J Clin Invest 118:763-76. 2008
    ..This effect is sufficient to release CGRP, a key component of neurogenic inflammation, and warrants investigation into the role of TRPV1 and TRPA1 in LA-induced neurotoxicity...
  69. ncbi Novel migraine therapy with calcitonin gene-regulated peptide receptor antagonists
    Lars Edvinsson
    Lund University Hospital, Department of Medicine, Institute of Clinical Sciences, S 221 85 Lund, Sweden
    Expert Opin Ther Targets 11:1179-88. 2007
    ..Research indicates that they effect the abluminal side of the blood-brain barrier and that they are not vasoconstrictive, providing a new dimension in therapy...
  70. ncbi Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial
    Tony W Ho
    Merck Research Laboratories, North Wales, PA 19454 1099, USA
    Lancet 372:2115-23. 2008
    ..We aimed to assess the clinical profile of MK-0974 (telcagepant), an orally bioavailable antagonist of CGRP receptor...
  71. ncbi The blood-brain barrier in migraine treatment
    L Edvinsson
    Department of Internal Medicine, University Hospital, Lund, Sweden
    Cephalalgia 28:1245-58. 2008
    ..We discuss how this can be related to genuine migraine attacks. Our view is that there exists no clear proof of breakdown or leakage of the BBB during migraine attacks, and that antimigraine drugs need to pass the BBB for efficacy...
  72. ncbi Calcitonin gene-related peptide in cervicogenic headache
    A Frese
    Department of Neurology, University of Munster, Germany
    Cephalalgia 25:700-3. 2005
    ..In certain cases, clinical differentiation between CEH and migraine without aura is difficult. Plasma CGRP levels might serve as a biological marker to distinguish the two headache entities...
  73. pmc Inhibition of calcitonin gene-related peptide function: a promising strategy for treating migraine
    Paul L Durham
    Department of Biology, Missouri State University, Springfield, MO 65897, USA
    Headache 48:1269-75. 2008
    ..This review will summarize key preclinical data that support the therapeutic potential of using CGRP receptor antagonists or molecules that bind CGRP within the context of current neurovascular theories on migraine pathology...
  74. ncbi Positive inotropy mediated via CGRP receptors in isolated human myocardial trabeculae
    O Saetrum Opgaard
    Department of Pharmacology, Erasmus University, 3000 DR, Rotterdam, Netherlands
    Eur J Pharmacol 397:373-82. 2000
    ..mRNAs for calcitonin receptor-like receptor and specific RAMPs further support the presence of CGRP receptors...
  75. ncbi Characterisation of CGRP receptors in human and porcine isolated coronary arteries: evidence for CGRP receptor heterogeneity
    Saurabh Gupta
    Department of Pharmacology, University Medical Center Rotterdam, The Netherlands
    Eur J Pharmacol 530:107-16. 2006
    ....
  76. ncbi Characterisation of CGRP receptors in the human isolated middle meningeal artery
    Saurabh Gupta
    Department of Pharmacology, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Life Sci 79:265-71. 2006
    ..This view is reinforced by Schild plot analysis, which revealed a slope of unity in all experiments, giving further evidence for a homogeneous CGRP receptor population in this vascular preparation...
  77. ncbi The cardioprotection of calcitonin gene-related peptide-mediated preconditioning
    Yuan Jian Li
    Department of Pharmacology, Xiang Ya School of Medicine, Central South University, Hunan, Changsha 410078, PR China
    Eur J Pharmacol 442:173-7. 2002
    ..It has been shown that the cardioprotection afforded by CGRP-mediated preconditioning is due to inhibition of cardiac tumor necrosis factor-alpha (TNF-alpha) production, but not to the activation of the K(ATP) channel...
  78. ncbi Calcitonin gene-related peptide-containing pathways in the rat forebrain
    Arpad Dobolyi
    Laboratory of Genetics, National Institutes of Mental Health, Bethesda, Maryland 20892, USA
    J Comp Neurol 489:92-119. 2005
    ..This description of the forebrain CGRP system will facilitate investigation of its role in higher brain functions...
  79. ncbi CGRP may play a causative role in migraine
    L H Lassen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Cephalalgia 22:54-61. 2002
    ..As intravenous administration of halphaCGRP causes headache and migraine in migraineurs, our study suggests that the increase in CGRP observed during spontaneous migraine attacks may play a causative role...
  80. ncbi The co-expression of ASIC3 with calcitonin gene-related peptide and parvalbumin in the rat trigeminal ganglion
    Hiroichi Ichikawa
    Department of Oral Function and Anatomy and Biodental Research Center, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8525, Japan
    Brain Res 943:287-91. 2002
    ..ASIC3-IR neurons which have large myelinated axons may be common in the tooth pulp but not the facial skin. The axonal morphology of ASIC3-IR TG neurons may depend on the variety of their receptive fields...
  81. ncbi Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR
    Matthew Conner
    School of Biosciences, University of Birmingham, UK
    Biochemistry 47:8434-44. 2008
    ..This helix structure appears to be found in most other family B GPCRs...
  82. pmc Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide
    Theodore J Price
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, USA
    Br J Pharmacol 141:1118-30. 2004
    ..These findings are discussed in relation to our current understanding of interactions between the cannabinoid and vanilloid systems and nociceptive processing in the periphery...
  83. ncbi An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres
    D Smith
    Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, UK
    Cephalalgia 22:424-31. 2002
    ..fibres. This suggests that 5-HT1D-receptors can regulate the release of CGRP and substance P and may be relevant to the clinical effectiveness of 5-HT1B/1D-receptor agonists in the treatment of migraine and other cranial pain syndromes...
  84. ncbi Calcitonin gene-related peptide antagonists as treatments of migraine and other primary headaches
    Peter J Goadsby
    Headache Group, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London, UK
    Drugs 65:2557-67. 2005
    ..The prospect of a non-vasoconstricting therapy for acute migraine offers a real opportunity to patients, and perhaps more importantly, provides a therapeutic rationale to reinforce migraine as a neurological disorder...
  85. ncbi Involvement of CGRP and CGRPl receptor in nociception in the basolateral nucleus of amygdala of rats
    Ning Li
    Weifang Medical University, Weifang 261042, Shandong Province, People s Republic of China
    Neurosci Lett 443:184-7. 2008
    ..Taken together, the results indicate that both CGRP and CGRP1 receptor play important roles in nociceptive modulation in the BLA of rats...
  86. ncbi In-depth characterization of CGRP receptors in human intracranial arteries
    Inger Jansen-Olesen
    Department of Neurology, Glostrup Hospital, Nordre Ringvej 57 Dk 2600 Glostrup, Denmark
    Eur J Pharmacol 481:207-16. 2003
    ..In conclusion, our molecular and pharmacological data support the existence of a single type of CGRP(1) receptors in the human intracranial circulation...
  87. ncbi No increase of calcitonin gene-related peptide in jugular blood during migraine
    Jesper Filtenborg Tvedskov
    Danish Headache Center, University of Copenhagen and Department of Neurology, Glostrup University Hospital, Glostrup, Copenhagen, Denmark
    Ann Neurol 58:561-8. 2005
    ..Our finding strongly suggests that CGRP is not increased in jugular venous blood during migraine without aura. CGRP cannot be used as a biomarker to validate human or animal models of migraine...
  88. pmc Calcitonin gene-related peptide stimulation of nitric oxide synthesis and release from trigeminal ganglion glial cells
    Jing Li
    Department of Biology, Missouri State University, Springfield, Missouri 65897, USA
    Brain Res 1196:22-32. 2008
    ....
  89. ncbi Chemical sympathectomy-induced changes in TH-, VIP-, and CGRP-immunoreactive fibers in the rat mandible periosteum: influence on bone resorption
    M Cherruau
    Laboratoire de Biologie et Physiopathologie Cranio faciales, Faculte de Chirurgie Dentaire, Universite Rene Descartes Paris 5, Arnoux Montrouge, France
    J Cell Physiol 194:341-8. 2003
    ..Nevertheless, these fibers did not originate from the SCG, contrary to TH-IR fibers...
  90. ncbi Neuronal regulation of bone metabolism and anabolism: calcitonin gene-related peptide-, substance P-, and tyrosine hydroxylase-containing nerves and the bone
    Shinji Imai
    Department of Orthopeadic Surgery, Shiga University of Medical Science, Setatsukinowa cho, Otsu City, 520 2192, Shiga ken, Japan
    Microsc Res Tech 58:61-9. 2002
    ....
  91. ncbi Visualizing cold spots: TRPM8-expressing sensory neurons and their projections
    Ajay Dhaka
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 28:566-75. 2008
    ..We show that TRPM8 expression functionally associates with cold sensitivity in cultured DRGs, and provide the first glimpses of the unique anatomical architecture of cold fibers in vivo...
  92. ncbi Functional antagonism between endogenous neuropeptide Y and calcitonin gene-related peptide in mesenteric resistance arteries
    Jo G R De Mey
    Department of Pharmacology and Toxicology, Universiteit Maastricht, P O Box 616, 6200 MD, Maastricht, The Netherlands
    J Pharmacol Exp Ther 324:930-7. 2008
    ....
  93. ncbi 5-HT(1B) and 5-HT(1D) receptors in the human trigeminal ganglion: co-localization with calcitonin gene-related peptide, substance P and nitric oxide synthase
    M Hou
    Department of Internal Medicine, Lund University Hospital, Lund, Sweden
    Brain Res 909:112-20. 2001
    ..r. cells contained NOS. In conclusion, both 5-HT(1B) and 5-HT(1D) receptors are expressed in the human trigeminal ganglion and they are mainly localized in medium-sized cells and they seem to colocalize with CGRP, SP and NOS...
  94. ncbi Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat
    Graeme S Cottrell
    Department of Surgery, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0660, USA
    J Comp Neurol 490:239-55. 2005
    ..receptor (CLR) and receptor activity modifying protein 1 (RAMP1) comprise a receptor for calcitonin gene related peptide (CGRP) and intermedin...
  95. pmc Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding
    Sugato Banerjee
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58202 9037, USA
    BMC Pharmacol 6:9. 2006
    ..Therefore, we hypothesize that hydrophobic amino acids within the previously characterized 18 amino acid CLR N-terminus domain are important binding contacts for the C-terminal phenylalaninamide of CGRP...
  96. ncbi Interleukin-1beta induces beta-calcitonin gene-related peptide secretion in human type II alveolar epithelial cells
    Wenjing Li
    Institute of Vascular Medicine, Peking University Third Hospital, Beijing 100083, P R of China
    FASEB J 18:1603-5. 2004
    ..These results suggest that AEII-derived CGRP may act in an autocrine/paracrine mode and play an important inhibitory role in the local area in lung inflammatory diseases...
  97. ncbi Critical role of calcitonin gene-related peptide 1 receptors in the amygdala in synaptic plasticity and pain behavior
    Jeong S Han
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 25:10717-28. 2005
    ..This study provides direct evidence for the critical dependence of pain behavior on CGRP1-mediated amygdala plasticity...
  98. ncbi Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist
    N Aiyar
    Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406 0939, USA
    J Pharmacol Exp Ther 296:768-75. 2001
    ..These results suggest that SB-(+)-273779 is a valuable tool for studying CGRP-mediated functional responses in complex biological systems...
  99. ncbi Expression of interleukin-1 beta in rat dorsal root ganglia
    J C Copray
    Department of Medical Physiology, University of Groningen, A Deusinglaan 1, Bloemsingel 10, 9713 AV KZ, Groningen, Netherlands
    J Neuroimmunol 118:203-11. 2001
    ..The functional significance of IL-1beta in the DRG neurons needs to be elucidated, but we speculate that IL-1beta produced by DRG neurons may be an auto/paracrine signalling molecule in sensory transmission...
  100. ncbi Calcitonin gene-related peptide (CGRP) as hazard marker for lung injury induced by dusts
    Yasuo Morimoto
    Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Yahatanishi, Kitayushu, Japan
    Inhal Toxicol 19:283-9. 2007
    ..These data suggest that CGRP is associated with repair in lung damaged by different dusts, and that CGRP could be used as a sensitive biomarker to indicate the pathogenicity of dusts...
  101. pmc Pain-related synaptic plasticity in spinal dorsal horn neurons: role of CGRP
    Gary C Bird
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    Mol Pain 2:31. 2006
    ..Here we address the role of CGRP in synaptic plasticity in the spinal dorsal horn in a model of arthritic pain...

Research Grants65

  1. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
  2. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..The results would open a new field of study and point the way to new avenues of investigation for pharmacological agents to treat diarrhea and/or constipation. ..
  3. The unique role of B-Raf in murine cardiac development and postnatal function
    Natasha N Chattergoon; Fiscal Year: 2013
    ..We will couple the results of B-Raf disruption to morphological, biochemical, and functional parameters of cardiac performance in the newborn and adult using echocardiographic measures. (End of Abstract) ..
  4. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..These results should help both elucidate the importance of primary sensory innervation in the pathogenesis of pancreatitis and provide possible new strategies for the treatment of pancreatitis. ..
  5. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2013
    ....
  6. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ....
  7. Role of TRP Channels in Environmental Irritant-Induced Headache
    Gerry S Oxford; Fiscal Year: 2013
    ..The goal of the proposed studies is to determine whether environmental irritants activate the trigeminovascular system via binding to chemical sensing receptors known as TRP channels. ..
  8. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    JOHN GRIDER; Fiscal Year: 2009
    ..abstract_text> ..
  9. Neurogenic inflammation and psoriasiform dermatitis
    NICOLE LEANNE WARD; Fiscal Year: 2013
    ..applicant): Psoriatic skin contains more nerve fibers and increased levels of sensory nerve-derived calcitonin gene related peptide (CGRP) and substance P (SP)...
  10. Inflammasome Activation in Complex Regional Pain Syndrome
    Wade S Kingery; Fiscal Year: 2013
    ..We will test the hypothesis that substance P (SP), calcitonin gene related peptide (CGRP) and beta 2 adrenergic receptor agonists stimulate the production of key inflammasome ..
  11. The role of BNST CGRP in stress-enhanced anxiety behavior and HPA-axis function
    Kelly S Sink; Fiscal Year: 2013
    ....
  12. The role of stress and mast cells in a preclinical mouse model of migraine
    ANN CHRISTINE RADDANT; Fiscal Year: 2013
    ..Additionally, it will provide some insight into the mechanism of how stress precipitates migraine. Overall, this project will assess the first evidence of a physiological trigger of a migraine symptom in an animal model. ..
  13. CGRP-induced light aversion in a preclinical migraine model
    Andrew F Russo; Fiscal Year: 2013
    ..The impact of this proposal will be a validated preclinical model for translational studies to develop new therapeutics for migraine. ..
  14. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..If successful, these studies could provide a rationale for designing clinical studies to further test the efficacy of angiotensin converting enzyme and/or vasopeptidase inhibitor treatment in human diabetic neuropathy. ..
  15. Treat Neuropathic Pain with Dissolvable Microneedles Containing Anti-CGRP Peptide
    Xinmin Simon Xie; Fiscal Year: 2013
    ....
  16. NEURONAL CONTROL OF CGRP GENE EXPRESSION
    ANDREW RUSSO; Fiscal Year: 2009
    ..The significance of this proposal is that it will restablish a molecular mechanism linking cytokines and neuropeptides and potentially reveal new therapeutic (strategies to attenuate neuropeptide synthesis. ..
  17. Sex Steroid Hormones and Calcitonin Gene-Related Peptide
    Chandrasekhar Yallampalli; Fiscal Year: 2013
    ....
  18. Mechanisms of airway neurogenic inflammation by asthma-inducing allergens
    Armen N Akopian; Fiscal Year: 2013
    ..This conceptually innovative hypothesis which proposes distinct mechanisms of airway inflammation by mold and house dust mite allergens has a strong potential for scientific and medical developments. ..
  19. RAMP-altered Class B GPCR Hormone Recognition
    Augen A Pioszak; Fiscal Year: 2013
    ..Achieving these aims will define the molecular bases for RAMP-altered class B GPCR hormone recognition and provide structural templates to guide the rational design of therapeutic agents targeting the receptors. ..
  20. Coronary Dysregulation Associated with Obesity
    Christine L Oltman; Fiscal Year: 2013
    ..With the global increase in type II diabetes and onset of obesity increasing in younger populations, the burden to deliver health care to these individuals will continue to increase. ..
  21. Ethanol Prevents Microvascular Dysfunction
    Ronald J Korthuis; Fiscal Year: 2010
    ....
  22. Community-Based, Phase III Trial of acupuncture to treat chronic Xerostomia
    Lorenzo Cohen; Fiscal Year: 2013
    ..Examine the role of expectancy for the benefits of acupuncture in predicting outcomes. The role of expectancy as a moderator of the effects of treatment will be thoroughly examined. ..
  23. AMY-1 receptors: Novel targets for antipsychotic development
    Brian A Baldo; Fiscal Year: 2012
    ..In the course of this last study, we will also determine whether amylin-related genes themselves are developmentally regulated. ..
  24. The Responses of Thermoregulatory Neurons to CGRP
    John Griffin; Fiscal Year: 2009
    ..Clinically, this research may identify new sites of therapeutic intervention in the treatment of this transient hyperthermic shift in body temperature, known as a hot flash. ..
  25. Role of CGRP in the association between migraine and obesity
    ANA RECOBER-MONTILLA; Fiscal Year: 2013
    ..These studies will be the first to address the molecular basis of the association between obesity and migraine. ..
  26. Genetic targeting of CGRP actions in a murine model of migraine
    ERIC ALAN KAISER; Fiscal Year: 2011
    ..The Resume and Summary of Discussion above summarizes the final outcome of the group discussion. ..
  27. Epithelial Stem Cells in Lung Transplantation
    Kalpaj Parekh; Fiscal Year: 2013
    ..Specifically, this proposal will focus on the contribution of denervation to aberrant calcitonin gene related peptide (CGRP) neuropeptide responses that control stem cell proliferation in the airways...
  28. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
    ....
  29. Mouse model of vestibulodynia using recurrent vulvovaginal Candidiasis
    MELISSA ANNE FARMER; Fiscal Year: 2010
    ..5 immunohistochemistry) and markers of nociception (via calcitonin gene related peptide and the vanilloid receptor TRPV1);(c) to examine the immunological profile of vulvar tissue following ..
  30. Development of Topical Neuroinflammatory Inhibitors
    MANDIP SACHDEVA; Fiscal Year: 2005
    ..The results of these studies are intended to provide the basic information required for the development of novel skin disorders. ..
  31. PERINATAL PULMONARY CIRCULATION--VASOACTIVE MEDIATORS
    Michael Heymann; Fiscal Year: 1999
    ....
  32. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    ..Because a gender difference is reported for TMD and FM, both hypotheses will be tested in males, estrous females and diestrous females. ..
  33. Radiation-Induced Heart Disease: Mechanisms and Interventions
    Marjan Boerma; Fiscal Year: 2013
    ....
  34. NEUROGENIC MECHANISMS OF INTESTINAL INFLAMMATION
    Eileen Grady; Fiscal Year: 2006
    ..Together, the results of these experiments will provide new insights into peptide signaling, generate novel information about mechanisms of intestinal inflammation, and suggest new strategies for therapy. ..
  35. PERIPHERAL CANNABINOIDS AND NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2002
    ..This knowledge base may provide a rationale for developing peripherally-selective cannabinoid analgesics with minimal CNS-mediated side-effect liability. ..
  36. NEUROTRANSMITTERS AND CYTOKINES IN TOOTH MOVEMENT
    ZEEV DAVIDOVITCH; Fiscal Year: 1992
    ..Such information on the mode of action of specific products of nervous and inflammatory cells may lead to the development of new diagnostic and therapeutic means in orthodontics...
  37. BRAIN REGULATING GASTRIC ACID FUNCTION BY NEUROPEPTIDES
    YVETTE TACHE; Fiscal Year: 2000
    ....
  38. Ontogeny of CRLR and RAMPs in Myometrium
    Chandrasekhar Yallampalli; Fiscal Year: 2002
    ..A necessary first step is the development of quality reagents to aid in this study and for further use in probing receptor structure/function relationships. ..
  39. DYNORPHIN MODULATES CGRP RELEASE VIA PKC
    Zaijie Jim Wang; Fiscal Year: 2003
    ..Frank Porreca and Josephine Lai. This award is consistent with the long-term career goal of the candidate to become an independent investigator contributing to the basic research of pain and opioid pharmacology. ..
  40. Intermedin / AM2 in Human Pregnancy
    MADHU LATA CHAUHAN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Calcitonin (CT), calcitonin gene related peptide CGRP, amylin and adrenomedullin (AM) belong to a unique group of peptide, hormones, important for homeostasis...
  41. REGULATION OF ALTERNATIVE PROCESSING OF CALCITONIN/CGRP
    Susan Berget; Fiscal Year: 2002
    ..The overall goal of these experiments is to understand how an enhancer resembling an exon participates in both polyadenylation and splicing of neighboring exons. ..
  42. INDUCIBLE ALTERATION OF CGRP IN PRIMARY AFFERENT NEURONS
    KARIN WESTLUND HIGH; Fiscal Year: 1993
    ..Increased dietary calcium has been shown to lower blood pressure in spontaneously hypertensive rats, indicating that increased knowledge of the mechanisms under study could have direct clinical applications...
  43. Efferent Signaling through the CGRP receptor complex
    RHIANNON BUSSEY; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  44. CALCITONIN GENE-RELATED PEPTIDE IN HYPERTENSION
    Gianfranco Alpini; Fiscal Year: 2006
    ..abstract_text> ..
  45. LANGERHANS CELLS AND NERVES: BIDIRECTIONAL SIGNALING
    Richard Granstein; Fiscal Year: 2009
    ..Immune responses in the skin. ..
  46. ROLE OF THE NEUROLOGIC SYSTEM IN CUTANEOUS ANGIOGENESIS
    JOHN ANSEL; Fiscal Year: 2004
    ..aspects of cutaneous angiogenesis by the release of neuropeptides such as substance P (SP) and calcitonin gene related peptide (CGRP)...
  47. CALCITONIN GENE RELATED PEPTIDE AND AGING
    PANDU GANGULA; Fiscal Year: 2000
    ..These studies are important for the assessing whether increased levels of CGRP by steroid hormones play a role in decreasing cardiovascular disorders that are typical of aged women after several years of menopause. ..
  48. CONTROL OF NEUROENDOCRINE GENE EXPRESSION
    STUART LEFF; Fiscal Year: 1992
    ....
  49. MOLECULAR BASIS OF VESTIBULAR EFFERENT FUNCTION
    P Wackym; Fiscal Year: 1999
    ..In addition, molecular characterization of these neurotransmitter and receptor distributions may lead to advances in the pharmacotherapy of patients with vestibular dysfunction. ..
  50. Human Fetoplacental Vasculature and CGRP
    Yuan Lin Dong; Fiscal Year: 2005
    ..Our results may indicate that CGRP has vasodilatory effects on human fetoplacental vasculature and is regulated by sex steroid hormones, as well as elucidate the role of CGRP in IUGR and/or preeclampsia. ..
  51. Molecular Mechanisms Critical to CGRP Receptor Signaling
    James Porter; Fiscal Year: 2003
    ....
  52. ORGANIZATION AND EXPRESSION OF CGRP IN THE PANCREAS
    Catia Sternini; Fiscal Year: 1991
    ....
  53. CONTROL OF NEUROENDOCRINE GENE EXPRESSION
    STUART LEFF; Fiscal Year: 1993
    ....
  54. MECHANISMS REGULATING ATRIOPEPTIN SECRETION
    Rick Schiebinger; Fiscal Year: 1991
    ..Thus, this project may lead to important discoveries which may ultimately prove beneficial in treating cardiovascular diseases...
  55. CGRP IN SUBARACHNOID HEMORRHAGE
    ANDREW RUSSO; Fiscal Year: 2001
    ..Insight into regulation of CGRP gene expression may facilitate treatment, including gene therapy, for prevention of cerebral vasospasm after SAH. ..
  56. Inflammatory Signaling Mechanisms of the CGRP Receptor
    James Porter; Fiscal Year: 2004
    ..abstract_text> ..
  57. PROTEIN ENGINEERING - PEPTIDE HORMONE DESIGN
    John Taylor; Fiscal Year: 1993
    ..Neuropeptide Y (NPY), calcitonin and calcitonin gene related peptide (CGRP) will serve as examples where there is already good evidence that amphiphilic alpha-helical ..
  58. CGRP CONTROL OF HUMAN MYOMETRIAL CONTRACTILITY
    Yuan Lin Dong; Fiscal Year: 2001
    ..This study will define the role of CORP in the maintenance of human uterine quiescence during pregnancy. Knowledge gained from these studies may assist in designing appropriate therapeutic strategies to reduce premature parturition. ..
  59. MEDIAL THALAMIC MECHANISMS OF NOCICEPTION
    Vjekoslav Miletic; Fiscal Year: 1991
    ..The proposal should increase our knowledge of nociception at spinal, trigeminal, thalamic and cortical levels, and this knowledge might lead to significant advances in dental and cutaneous pain management...
  60. CGRP, NO, AND SEPSIS INDUCED MICROVASCULAR DYSFUNCTION
    WARWICK ARDEN; Fiscal Year: 2002
    ..These techniques will allow the investigator to determine whether changes in vascular responses correlate with changes in intracellular calcium-mediated directly or indirectly by CGRP and/or NO. ..
  61. Functional role of CGRP as an efferent neurotransmitter
    Colleen Le Prell; Fiscal Year: 2007
    ..2004). ..
  62. Adrenomedullin and Human Trophoblast Invasion
    Yuan Lin Dong; Fiscal Year: 2006
    ..Knowledge gained from these studies may assist in designing appropriate therapeutic strategies to prevent preeclampsia in the human. ..
  63. Nitric Oxide Control of CGRP in Trigeminal Neurons
    Paul Durham; Fiscal Year: 2002
    ..abstract_text> ..
  64. CGRP CONTROL IN TRIGEMINAL NEURONS IN VITRO AND IN VIVO
    Paul Durham; Fiscal Year: 2006
    ..abstract_text> ..
  65. Low birth weight, uterine infection, and nitric oxide
    Chandrasekhar Yallampalli; Fiscal Year: 2007
    ..2 will test the hypothesis that NO donor can reverse the increases in DAF expression in uteroplacental and vascular tissues and in fetal growth restriction ..