bradykinin

Summary

Summary: A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.

Top Publications

  1. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004
  2. ncbi Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain
    Stefania Ceruti
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 31:3638-49. 2011
  3. ncbi Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain
    Shenglan Wang
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Brain 131:1241-51. 2008
  4. pmc The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels
    Boyi Liu
    Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
    J Clin Invest 120:1240-52. 2010
  5. ncbi The bradykinin-forming cascade and its role in hereditary angioedema
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Ann Allergy Asthma Immunol 104:193-204. 2010
  6. ncbi Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway
    Hsin Shan Yu
    Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
    Prostate 73:89-100. 2013
  7. ncbi Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo
    Chris Oschatz
    Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Immunity 34:258-68. 2011
  8. ncbi Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: consensus report of an International Working Group
    M Cicardi
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Ospedale L Sacco, Milano, Italy
    Allergy 67:147-57. 2012
  9. pmc Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptors
    J Scharfstein
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CEP 21990 400 Rio de Janeiro, Brazil
    J Exp Med 192:1289-300. 2000
  10. ncbi Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS
    Robert M Bell
    Hatter Institute for Cardiovascular Studies, Centre for Cardiology, Division of Medicine, University College London Hospitals and Medical School, Grafton Way, London WC1E 6DB, UK
    J Mol Cell Cardiol 35:185-93. 2003

Detail Information

Publications339 found, 100 shown here

  1. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004
    ..b>Bradykinin, an inflammatory peptide acting through its G protein-coupled receptor, also activates TRPA1...
  2. ncbi Calcitonin gene-related peptide-mediated enhancement of purinergic neuron/glia communication by the algogenic factor bradykinin in mouse trigeminal ganglia from wild-type and R192Q Cav2.1 Knock-in mice: implications for basic mechanisms of migraine pain
    Stefania Ceruti
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 31:3638-49. 2011
    ..We previously showed that the algogenic mediator bradykinin (BK) potentiates purinergic P2Y receptors on SGCs in primary trigeminal cultures...
  3. ncbi Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain
    Shenglan Wang
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Brain 131:1241-51. 2008
    b>Bradykinin is an inflammatory mediator that plays a pivotal role in pain and hyperalgesia in inflamed tissues by exciting and/or sensitizing nociceptors...
  4. pmc The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl- channels
    Boyi Liu
    Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
    J Clin Invest 120:1240-52. 2010
    b>Bradykinin (BK) is an inflammatory mediator and one of the most potent endogenous pain-inducing substances...
  5. ncbi The bradykinin-forming cascade and its role in hereditary angioedema
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Ann Allergy Asthma Immunol 104:193-204. 2010
    To review the mechanisms by which bradykinin is generated in hereditary angioedema (HAE) (C1 inhibitor deficiency), including the role of human plasma proteins and endothelial cells.
  6. ncbi Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c-Src dependent signaling pathway
    Hsin Shan Yu
    Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
    Prostate 73:89-100. 2013
    ..b>Bradykinin (BK) is an inflammatory mediator, and shows elevated levels in regions of severe injury and inflammatory ..
  7. ncbi Mast cells increase vascular permeability by heparin-initiated bradykinin formation in vivo
    Chris Oschatz
    Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
    Immunity 34:258-68. 2011
    ..Heparin activated the protease factor XII, which initiates bradykinin formation in plasma...
  8. ncbi Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: consensus report of an International Working Group
    M Cicardi
    Dipartimento di Scienze Cliniche Luigi Sacco, Universita di Milano, Ospedale L Sacco, Milano, Italy
    Allergy 67:147-57. 2012
    ..Here, we report the topics discussed during the meeting and evidence-based consensus about management approaches for HAE in adult/adolescent patients...
  9. pmc Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptors
    J Scharfstein
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CEP 21990 400 Rio de Janeiro, Brazil
    J Exp Med 192:1289-300. 2000
    ..umbilical vein endothelial cells (HUVECs) or Chinese hamster ovary (CHO) cells overexpressing the B(2) type of bradykinin receptor (CHO-B(2)R) by tissue culture trypomastigotes is subtly modulated by the combined activities of ..
  10. ncbi Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS
    Robert M Bell
    Hatter Institute for Cardiovascular Studies, Centre for Cardiology, Division of Medicine, University College London Hospitals and Medical School, Grafton Way, London WC1E 6DB, UK
    J Mol Cell Cardiol 35:185-93. 2003
    ..kinase (PI3K) and protein kinase B (Akt), a pathway also linked to the phosphorylation of eNOS by bradykinin. We, therefore, hypothesised that bradykinin would limit infarct size when given as an adjunct to reperfusion...
  11. pmc Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin
    Megan Grace
    Respiratory Pharmacology Group, Pharmacology and Toxicology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Thorax 67:891-900. 2012
    ..Endogenous inflammatory mediators such as prostaglandin E2 (PGE2) and bradykinin (BK), which are often elevated in respiratory disease states, are also known to cause cough by stimulating ..
  12. ncbi Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi
    Ana Carolina Monteiro
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro UFRJ, Centre de Ciências da Saúde, Sala D 007, Rio de Janeiro, Brazil
    J Immunol 177:6325-35. 2006
    We have previously reported that exogenous bradykinin activates immature dendritic cells (DCs) via the bradykinin B(2) receptor (B(2)R), thereby stimulating adaptive immunity...
  13. ncbi Descriptive and functional neuroanatomy of locus coeruleus-noradrenaline-containing neurons involvement in bradykinin-induced antinociception on principal sensory trigeminal nucleus
    Lucélio Bernardes Couto
    Laboratory of Pharmacology, School of Pharmaceutical Sciences of Ribeirão Preto, University of Sao Paulo, 3900, Ribeirao Preto SP, 14049 900, Brazil
    J Chem Neuroanat 32:28-45. 2006
    ..The effects of microinjections of bradykinin into the principal sensory trigeminal nucleus (PSTN) before and after neurochemical lesions of the locus ..
  14. ncbi A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin
    H Y Yang
    Biochim Biophys Acta 214:374-6. 1970
  15. ncbi Randomized placebo-controlled trial of the bradykinin B₂ receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: the FAST-3 trial
    William R Lumry
    Allergy and Asthma Research Associates Research Center, Dallas, Texas 75081, USA
    Ann Allergy Asthma Immunol 107:529-37. 2011
    ..Treatment (FAST)-3 study was a phase III, randomized, double-blind, placebo-controlled study of icatibant (bradykinin B(2) receptor antagonist) in subjects with hereditary angioedema (HAE) resulting from C1-INH deficiency or ..
  16. ncbi Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury
    Pau Sancho-Bru
    Liver Unit, Institut Clinic de Malalties Digestives i Metaboliques, Barcelona, Catalonia, Spain
    Gastroenterology 133:2019-28. 2007
    Recent studies have suggested that the kallikrein-kinin system regulates tissue fibrogenesis. We hypothesize that bradykinin (BK), the main effector peptide of this system, regulates hepatic fibrogenesis.
  17. pmc Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus
    Takahisa Imamura
    Division of Molecular Pathology, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    J Exp Med 201:1669-76. 2005
    ..aureus. Proteolytically active staphopain A (ScpA) induced VL in a bradykinin (BK) B(2)-receptor-dependent manner in guinea pig skin...
  18. ncbi Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed-onset muscle soreness)
    Shiori Murase
    Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 8601, Japan
    J Neurosci 30:3752-61. 2010
    ..Using B(2) bradykinin receptor antagonist HOE 140, we show here that bradykinin released during exercise plays a pivotal role in ..
  19. ncbi Bradykinin and high glucose promote renal tubular inflammation
    Sydney C W Tang
    Division of Nephrology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Nephrol Dial Transplant 25:698-710. 2010
    ..The role of the kallikrein-kinin system in diabetic nephropathy remains controversial...
  20. ncbi Assessment of microvascular endothelial function in human skin
    D J Newton
    Peripheral Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    Clin Sci (Lond) 101:567-72. 2001
    ..Cumulative doses of acetylcholine, methacholine, bradykinin and substance P were administered iontophoretically to the forearm skin of healthy volunteers on two to three ..
  21. ncbi Isolation and characterization of a novel bradykinin potentiating peptide (BPP) from the skin secretion of Phyllomedusa hypochondrialis
    Katia Conceição
    Laboratório Especial de Toxinologia Aplicada, Center for Applied Toxinology CAT CEPID, Instituto Butantan, Avenida Vital Brasil 1500, Sao Paulo, SP 05503 900, Brazil
    Peptides 28:515-23. 2007
    b>Bradykinin potentiating peptides (BPPs) from Bothrops jararaca venom were first described in the middle of 1960s and were the first natural inhibitors of the angiotensin-converting enzyme (ACE)...
  22. ncbi Bradykinin contributes to the vasodilator effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure
    F N Witherow
    Department of Cardiovascular Research, University of Edinburgh, Royal Infirmary of Edinburgh, Scotland, UK
    Circulation 104:2177-81. 2001
    BACKGROUND: Bradykinin, an endogenous vasodilator peptide, is metabolized by ACE...
  23. ncbi Hypertension and the bradykinin system
    Jagdish N Sharma
    Department of Applied Therapeutics, Faculty of Pharmacy, Health Sciences Center, Kuwait University, P O Box 24923, Safat 13110, Kuwait
    Curr Hypertens Rep 11:178-81. 2009
    ..The bradykinin system is involved in the mediation and modulation of the vasoconstrictor renin-angiotensin system and the ..
  24. ncbi Bradykinin-related peptides from Phyllomedusa hypochondrialis
    G D Brand
    Laboratório de Espectrometria de Massa, EMBRAPA, Recursos Genéticos e Biotecnologia, Brasilia, DF 70770 900, Brazil
    Peptides 27:2137-46. 2006
    b>Bradykinin related peptides (BRPs) present in the water-soluble secretion and freshly dissected skin fragments of Phyllomedusa hypochondrialis were investigated by mass spectrometry techniques...
  25. ncbi TRPC3 is involved in flow- and bradykinin-induced vasodilation in rat small mesenteric arteries
    Cui Ling Liu
    Department of Pathology, Peking University Health Science Center, Beijing 100083, China
    Acta Pharmacol Sin 27:981-90. 2006
    ..To test the possible involvement of TRPC3 in agonist-induced relaxation and flow-induced vasodilation in rat small mesenteric arteries...
  26. ncbi Role of bradykinin B2 and B1 receptors in the local, remote, and systemic inflammatory responses that follow intestinal ischemia and reperfusion injury
    Danielle G Souza
    Departamentos de Bioquímica e Imunologia, e Fisiologia e Biofísica, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Brazil
    J Immunol 172:2542-8. 2004
    The administration of bradykinin may attenuate ischemia and reperfusion (I/R) injury by acting on B(2)Rs. Blockade of B(2)R has also been shown to ameliorate lesions associated with I/R injury...
  27. ncbi Contact system activation in severe infectious diseases
    Sonja Oehmcke
    Department of Clinical Sciences, Division of Infection Medicine, BMC, B14, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
    J Mol Med (Berl) 88:121-6. 2010
    ..Contact activation leads to the release of the highly potent proinflammatory peptide bradykinin and initiates the intrinsic pathway of coagulation...
  28. pmc Spinal dynorphin and bradykinin receptors maintain inflammatory hyperalgesia
    Miaw Chyi Luo
    Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    J Pain 9:1096-105. 2008
    ..Recent findings implicate a direct excitatory action of dynorphin A at bradykinin receptors to promote hyperalgesia in nerve injured rats, and its upregulation may promote, rather than ..
  29. ncbi Multiple factors from bradykinin-challenged astrocytes contribute to the neuronal apoptosis: involvement of astroglial ROS, MMP-9, and HO-1/CO system
    Chuen Mao Yang
    Department of Physiology and Pharmacology and Health Aging Research Center, College of Medicine, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan, Taiwan
    Mol Neurobiol 47:1020-33. 2013
    b>Bradykinin (BK) has been shown to induce the expression of several inflammatory mediators, including reactive oxygen species (ROS) and matrix metalloproteinases (MMPs), in brain astrocytes...
  30. ncbi Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors
    Gábor Petho
    Pharmacodynamics Unit, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs, Hungary
    Physiol Rev 92:1699-775. 2012
    ..review aims to give an account of the excitatory and sensitizing actions of inflammatory mediators including bradykinin, prostaglandins, thromboxanes, leukotrienes, platelet-activating factor, and nitric oxide on nociceptive primary ..
  31. pmc Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment
    Maria Jelinic
    2Department of Zoology, The University of Melbourne, Parkville, Vic, 3010, Australia
    FASEB J 28:275-87. 2014
    ..Serelaxin treatment had no effect on acetylcholine-mediated relaxation but significantly (P<0.001) enhanced bradykinin (BK)-mediated relaxation in mesenteric arteries, involving enhanced nitric oxide but not endothelium-derived ..
  32. pmc Bradykinin-induced astrocyte-neuron signalling: glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels
    Hong Tao Liu
    Department of Cell Physiology, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji cho, Okazaki, Aichi 444 8585, Japan
    J Physiol 587:2197-209. 2009
    ..Previous studies showed that in response to stimulation with bradykinin, glutamate is released from rat astrocytes and causes NMDA receptor-mediated elevation of intracellular Ca(2+) ..
  33. ncbi The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill
    Amy L Cilia La Corte
    Proteolysis Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    J Renin Angiotensin Aldosterone Syst 9:221-5. 2008
    ..Angiotensin-converting enzyme (ACE) and aminopeptidase P (AP-P) are key enzymes in these systems and are both involved in the degradation of the vasodilator bradykinin.
  34. ncbi MARCKS dephosphorylation is involved in bradykinin-induced neurite outgrowth in neuroblastoma SH-SY5Y cells
    Atsuhiro Tanabe
    Laboratory of Pharmacology, School of Pharmacy, Kitasato University, Minato ku, Tokyo, Japan
    J Cell Physiol 227:618-29. 2012
    b>Bradykinin (BK) plays a major role in producing peripheral sensitization in response to peripheral inflammation and in pain transmission in the central nerve system (CNS)...
  35. ncbi Novel therapies for hereditary angioedema
    Bruce L Zuraw
    University of California San Diego, La Jolla, CA 92093 0732, USA
    Immunol Allergy Clin North Am 26:691-708. 2006
    ..divided into two groups: drugs that replace C1 inhibitor (C1INH) functional activity and drugs that abrogate the bradykinin-mediated increase in vascular permeability associated with HAE attacks...
  36. pmc Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying anion channels by Ca2+ nanodomains in mouse astrocytes
    Tenpei Akita
    Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8585, Japan
    J Physiol 589:3909-27. 2011
    ..in cultured mouse cortical astrocytes, VSOR channels are activated in response to an inflammatory mediator, bradykinin, even without an increase in cell volume...
  37. ncbi Effect of chronic angiotensin converting enzyme inhibition on angiotensin I and bradykinin metabolism in rats
    L Stanziola
    , , Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Am J Hypertens 12:1021-9. 1999
    ..of the angiotensin converting enzyme (ACE) inhibitor, enalapril, on the in vivo pulmonary inactivation of bradykinin (BK) and conversion of angiotensin I (Ang I)...
  38. pmc Key role for spinal dorsal horn microglial kinin B1 receptor in early diabetic pain neuropathy
    Sébastien Talbot
    Department of Physiology, Faculty of Medicine, Universite de Montreal, C, P, 6128, Succursale Downtown, Montreal, Quebec, H3C 3J7, Canada
    J Neuroinflammation 7:36. 2010
    ..This study aims at defining the role of microglial kinin B1R in diabetic pain neuropathy...
  39. ncbi Angiotensin and bradykinin: targets for the treatment of vascular and neuro-glial pathology in diabetic retinopathy
    Jennifer L Wilkinson-Berka
    Department of Physiology, The University of Melbourne, Grattan St, Parkville, Victoria 3010, Australia
    Curr Pharm Des 10:3313-30. 2004
    ..In the KKS, bradykinin (BK) and kallidin and their carboxypeptidase metabolites, des-Arg(9)-BK and des-Arg(10)-kallidin, are the ..
  40. ncbi Protein kinase C (PKC)-delta/-epsilon mediate the PKC/Akt-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 in MCF-7 cells stimulated by bradykinin
    S Greco
    Laboratory of Cellular Physiology, Department of Biological and Environmental Sciences and Technologies, DiSTeBA, Ecotekne, Via Provinciale per Monteroni, 73100 Lecce, Italy
    J Endocrinol 188:79-89. 2006
    In this paper the signal transduction pathways evoked by bradykinin (BK) in MCF-7 breast cancer cells were investigated...
  41. ncbi The plasma bradykinin-forming pathways and its interrelationships with complement
    Allen P Kaplan
    Medical University of South Carolina, Department of Medicine, 96 Jonathan Lucas Street, Charleston, SC 29425, United States
    Mol Immunol 47:2161-9. 2010
    The plasma bradykinin-forming cascade and the complement pathways share many elements, including cross-activation, common control mechanisms, and shared binding proteins...
  42. ncbi Bradykinin mediates cardiac preconditioning at a distance
    R G Schoemaker
    Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University, NL 3000 DR Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 278:H1571-6. 2000
    ..The role of bradykinin (BK) in remote cardiac preconditioning by MAO is investigated by antagonizing the BK B(2) receptor [Hoechst 140 (..
  43. ncbi Modulation of brain tumor capillaries for enhanced drug delivery selectively to brain tumor
    Keith L Black
    Maxine Dunitz Neurosurgical Institute and Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Cancer Control 11:165-73. 2004
    ..The blood-brain tumor barrier (BTB) significantly impedes delivery of most hydrophilic molecules to brain tumors. Several promising strategies, however, have been developed to overcome this problem...
  44. ncbi Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema
    Marco Cicardi
    Universita degli Studi di Milano, Milan
    N Engl J Med 363:532-41. 2010
    Hereditary angioedema is characterized by recurrent attacks of angioedema of the skin, larynx, and gastrointestinal tract. Bradykinin is the key mediator of symptoms. Icatibant is a selective bradykinin B2 receptor antagonist.
  45. ncbi Reactive Oxygen Species-Dependent c-Fos/Activator Protein 1 Induction Upregulates Heme Oxygenase-1 Expression by Bradykinin in Brain Astrocytes
    Hsi Lung Hsieh
    Division of Basic Medical Sciences, Department of Nursing, Chang Gung Institute of Technology, Tao Yuan, Taiwan
    Antioxid Redox Signal 13:1829-44. 2010
    ..Our previous studies have demonstrated that bradykinin (BK) induces the expression of several inflammatory proteins, including matrix metalloproteinase-9 and COX-2, ..
  46. ncbi Purinoceptor-mediated calcium signaling in primary neuron-glia trigeminal cultures
    Stefania Ceruti
    Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Cell Calcium 43:576-90. 2008
    ..treatment with pro-inflammatory agents, cultures were acutely (up to 3 min) or chronically (24 h) exposed to bradykinin. This resulted in potentiation of algogenic P2X(3) receptor-mediated calcium responses followed by their down-..
  47. ncbi Nonallergic angioedema: role of bradykinin
    M Bas
    Hals, Nasen und Ohrenklinik, Universitatsklinikum Dusseldorf, Dusseldorf, Germany
    Allergy 62:842-56. 2007
    Angioedema is an underestimated clinical problem. Many cases are nonallergic reactions, e.g. bradykinin-induced angioedema caused by genetic defects and angiotensin-converting enzyme (ACE) inhibitors...
  48. pmc Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential
    Nicolle Krankel
    Experimental Cardiovascular Medicine, Bristol Heart Institute, UK
    Circ Res 103:1335-43. 2008
    ..In transwell migration assays, bradykinin (BK) exerts a potent chemoattractant activity on CD133(+) and CD34(+) CPCs and EPCs via a B(2)R/phosphoinositide ..
  49. ncbi Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
    H H Chuang
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
    Nature 411:957-62. 2001
    ..b>Bradykinin and nerve growth factor (NGF) are two such pro-algesic agents that activate G-protein-coupled (BK2) and tyrosine ..
  50. ncbi Kallikrein kinin system activation in post-exercise hypotension in water running of hypertensive volunteers
    Francisco L Pontes
    Department of Rehabilitation, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Int Immunopharmacol 8:261-6. 2008
    ..Plasma kallikrein activity and bradykinin concentration increased immediately after exercise (P<0...
  51. ncbi Toll-like receptor stimulation induces airway hyper-responsiveness to bradykinin, an effect mediated by JNK and NF-kappa B signaling pathways
    Ofir Bachar
    Department of Otorhinolaryngology, Malmo University Hospital, Malmo, Sweden
    Eur J Immunol 34:1196-207. 2004
    ..TLR3 and TLR4 were examined in a mouse organ culture model of asthma focusing on the smooth muscle responses to bradykinin. TLR2, TLR3 and TLR4 mRNA, and TLR2 and TLR4 immunoreactivity were detected in the tracheal muscle layer...
  52. ncbi The kallikrein-kinin system: current and future pharmacological targets
    Marie Eve Moreau
    Faculty of Pharmacy, University of Montreal, Canada
    J Pharmacol Sci 99:6-38. 2005
    ..system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides)...
  53. ncbi Proteinase-activated receptor-4 (PAR4) activation leads to sensitization of rat joint primary afferents via a bradykinin B2 receptor-dependent mechanism
    Fiona A Russell
    Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta, Canada
    J Neurophysiol 103:155-63. 2010
    ..antagonist, pepducin P4pal-10, the transient receptor potential vanilloid-1 (TRPV1) antagonist, SB366791, or the bradykinin B(2) receptor antagonist, HOE140...
  54. ncbi Human bradykinin B(2) receptor is activated by kallikrein and other serine proteases
    C Hecquet
    Department of Pharmacology, University of Illinois College of Medicine at Chicago, Chicago, Illinois 60612, USA
    Mol Pharmacol 58:828-36. 2000
    b>Bradykinin (BK) and kallidin (Lys-BK), liberated from kininogens by kallikreins, are ligands of the BK B(2) receptor. We investigated whether kallikreins, besides releasing peptide agonist, could also activate the receptor directly...
  55. pmc Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation
    Jonas Fuxe
    Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California, USA
    Am J Pathol 178:2897-909. 2011
    ..in the airways of mice under four different conditions: i) baseline, ii) acute inflammation induced by bradykinin, iii) sustained inflammation after 7-day infection by the respiratory pathogen Mycoplasma pulmonis, or iv) ..
  56. pmc Bradykinin- and sodium nitroprusside-induced increases in capillary tube haematocrit in mouse cremaster muscle are associated with impaired glycocalyx barrier properties
    Jurgen W G E VanTeeffelen
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Physiol 586:3207-18. 2008
    ..Using intravital microscopic visualization of mouse cremaster muscle, we determined the effects of bradykinin (10(-5) M) and sodium nitroprusside (10(-6) M) on capillary tube haematocrit and glycocalyx barrier properties...
  57. ncbi Bradykinin does not induce gap formation between human endothelial cells
    Pia Jungmann
    Institute of Physiology II, University of Munster, Robert Koch Str 27b, 48149 Munster, Germany
    Pflugers Arch 455:1007-16. 2008
    ..A model substance for studies in vitro is the vasodilatory peptide bradykinin, which has important functions in inflammation and vascular fluid balance...
  58. ncbi Bradykinin induces matrix metalloproteinase-9 expression and cell migration through a PKC-delta-dependent ERK/Elk-1 pathway in astrocytes
    Hsi Lung Hsieh
    Department of Pharmacology, Chang Gung University, Tao Yuan, Taiwan
    Glia 56:619-32. 2008
    ..In our previous study, bradykinin (BK) has been shown to induce proMMP-9 expression via MAPKs and NF-kappaB in rat brain astrocytes (RBA-1)...
  59. ncbi Roles of the two active sites of somatic angiotensin-converting enzyme in the cleavage of angiotensin I and bradykinin: insights from selective inhibitors
    Dimitris Georgiadis
    Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Zografou, Athens, Greece
    Circ Res 93:148-54. 2003
    ..The in vivo contribution of each active site to the release of angiotensin II (Ang II) and the inactivation of bradykinin (BK) is still unknown...
  60. ncbi Two faces of high-molecular-weight kininogen (HK) in angiogenesis: bradykinin turns it on and cleaved HK (HKa) turns it off
    Y L Guo
    Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
    J Thromb Haemost 3:670-6. 2005
    ..Originally identified as a precursor of bradykinin, a bioactive peptide that regulates many cardiovascular processes, it is now recognized that HK plays important ..
  61. ncbi The C-type natriuretic peptide precursor of snake brain contains highly specific inhibitors of the angiotensin-converting enzyme
    Mirian A F Hayashi
    Center for Applied Toxinology CAT CEPID, Instituto Butantan, Avenue Vital Brazil 15600, Sao Paulo, SP 05530 900, Brazil
    J Neurochem 85:969-77. 2003
    The bradykinin-potentiating peptides from Bothrops jararaca venom are the most potent natural inhibitors of the angiotensin-converting enzyme...
  62. ncbi Purification and characterization of a thrombin like enzyme, elegaxobin II, with lys-bradykinin releasing activity from the venom of Trimeresurus elegans (Sakishima-Habu)
    Etsuko Oyama
    Department of Hygenic Chemistry, Meiji Pharmaceutical University, 2 522 1 Noshio Kiyose, Tokyo 204 8588, Japan
    Toxicon 41:559-68. 2003
    A thrombin like enzyme, named elegaxobin II, with Lys-bradykinin releasing activity was purified from the venom of Trimeresurus elegans (Sakishima-habu) by gel-filtration on Sephadex G-100, and ion-exchange chromatography on the Q-..
  63. ncbi PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents
    Hailin Zhang
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Neuron 37:963-75. 2003
    ..Finally, native or recombinant channels inhibited by muscarinic agonists can be activated by PIP(2). Our data strongly suggest that PIP(2) acts as a membrane-diffusible second messenger to regulate directly the activity of KCNQ currents...
  64. ncbi Effect of bradykinin, TGF-beta1, IL-1beta, and hypoxia on COX-2 expression in pulmonary artery smooth muscle cells
    D A Bradbury
    Division of Respiratory Medicine, University of Nottingham, City Hospital, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 283:L717-25. 2002
    ..b>Bradykinin, transforming growth factor-beta1 (TGF-beta1), and interleukin-1beta (IL-1beta) increased inducible COX-2 ..
  65. ncbi Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection
    Olaf Oldenburg
    Dept of Physiology, MSB 3074, Univ of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Am J Physiol Heart Circ Physiol 286:H468-76. 2004
    b>Bradykinin (BK) mimics ischemic preconditioning by generating reactive oxygen species (ROS)...
  66. ncbi Suppressed angiogenesis in kininogen-deficiencies
    Izumi Hayashi
    Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan
    Lab Invest 82:871-80. 2002
    ..FR190997, a nonpeptide mimic of bradykinin, promoted angiogenesis markedly, with concomitant increases in vascular endothelial growth factor mRNA...
  67. pmc Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats
    Juliana G Chichorro
    Department of Pharmacology, Biological Sciences Section, Federal University of Parana, PO Box 19031, Curitiba, PR, 81540 970, Brazil
    Br J Pharmacol 141:1175-84. 2004
    ..3. Conversely, both phases of nociception induced by 2.5% formalin were inhibited by the bradykinin (BK) B(2) receptor antagonist HOE140 (5 microg lip(-1)) or the selective beta(1)-adrenoceptor antagonist ..
  68. pmc Bradykinin-induced, endothelium-dependent responses in porcine coronary arteries: involvement of potassium channel activation and epoxyeicosatrienoic acids
    Arthur H Weston
    Faculty of Life Sciences, University of Manchester, G38 Stopford Building, Manchester M13 9PT
    Br J Pharmacol 145:775-84. 2005
    In coronary arteries, bradykinin opens endothelial intermediate- and small-conductance Ca2+-sensitive K+ channels (IK(Ca) and SK(Ca)) and, additionally, releases epoxyeicosatrienoic acids (EETs) from the endothelium...
  69. ncbi Bradykinin-induced functional competence and trafficking of the delta-opioid receptor in trigeminal nociceptors
    Amol M Patwardhan
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Neurosci 25:8825-32. 2005
    ..We evaluated the hypothesis that an inflammatory mediator, bradykinin (BK), evokes functional competence of the delta-opioid receptor (DOR) for inhibiting trigeminal ganglia (TG) ..
  70. ncbi The angiotensin-converting enzyme gene polymorphism and responses to angiotensins and bradykinin in the human forearm
    M A van Dijk
    Department of Nephrology, Leiden University Medical Centre, The Netherlands
    J Cardiovasc Pharmacol 35:484-90. 2000
    ..the D allele should therefore exhibit enhanced angiotensin I-induced vasoconstrictor responses and diminished bradykinin-induced vasodilator responses as compared with subjects homozygous for the insertion (I) allele...
  71. ncbi Kallikrein-kinin system activation in streptococcal toxic shock syndrome
    S Sriskandan
    Department of Infectious Diseases, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    Clin Infect Dis 30:961-2. 2000
    ..We speculate that bradykinin release following activation of the kallikrein-kinin system in streptococcal toxic shock may underlie the ..
  72. ncbi Bradykinin modulates spontaneous nerve growth factor production and stretch-induced ATP release in human urothelium
    Peter Ochodnicky
    Department of Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Pharmacol Res 70:147-54. 2013
    ..The muscle-contracting and pain-inducing peptide bradykinin is produced in various inflammatory and non-inflammatory pathologies associated with bladder overactivity, but ..
  73. ncbi Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production
    Y Yoke Keong
    Department of Biomedical Sciences, Universiti Putra Malaysia, Serdang, Malaysia
    Med Princ Pract 20:142-6. 2011
    ..The present study was conducted to assess the anti-inflammatory effect of a crude aqueous extract of Bixa orellana leaves (AEBO) and to examine the possible involvement of nitric oxide (NO) in its anti-inflammatory mechanism...
  74. ncbi Lys-des[Arg9]-bradykinin alters migration and production of interleukin-12 in monocyte-derived dendritic cells
    Rosalind Gulliver
    Centre for Asthma, Allergy and Respiratory Research, The University of Western Australia, and Lung Institute of Western Australia, Perth, Western Australia, Australia
    Am J Respir Cell Mol Biol 45:542-9. 2011
    ..is accompanied by an increased maturation of DCs and the generation of kinins, particularly Lys-des[Arg(9)]-bradykinin (Lda-BK)...
  75. ncbi Bradykinin enhances cell migration in human chondrosarcoma cells through BK receptor signaling pathways
    Wei Hung Yang
    Department of Orthopaedic Surgery, China Medical University Beigang Hospital, Yun Lin County, Taiwan
    J Cell Biochem 109:82-92. 2010
    b>Bradykinin (BK) is an inflammatory mediator, and shows elevated levels in regions of severe injury and inflammatory diseases. BK has recently been shown to be involved in carcinogenesis and cancer progression...
  76. ncbi Aliskiren increases bradykinin and tissue kallikrein mRNA levels in the heart
    Duncan J Campbell
    St Vincent s Institute of Medical Research, University of Melbourne, Melbourne, Victoria, Australia
    Clin Exp Pharmacol Physiol 38:623-31. 2011
    ..2 mg/kg per day) and their combination on angiotensin and bradykinin peptides in female heterozygous (mRen-2)27 rats, transgenic for the mouse renin gene. 3...
  77. pmc Interaction of Bacteroides fragilis and Bacteroides thetaiotaomicron with the kallikrein-kinin system
    Elizabeth C Murphy
    Department of Clinical Sciences, Lund, Division of Infection Medicine, Lund University, SE 22184 Lund, Sweden
    Microbiology 157:2094-105. 2011
    ..cleavage of high-molecular-mass kininogen (HK) resulting in release of the potent proinflammatory peptide bradykinin, and initiation of the intrinsic pathway of coagulation...
  78. ncbi Effect of thrombin and bradykinin on endothelial cell mechanical properties monitored through membrane deformation
    Charles M Cuerrier
    Departement de Pharmacologie, Universite de Sherbrooke, Sherbrooke, QC, J1H 5N4, Canada
    J Mol Recognit 22:389-96. 2009
    ..of human umbilical vein endothelial cells (HUVEC) in responses to two physiological agonists namely thrombin and bradykinin. We used the atomic force microscopy (AFM) technique to study changes in cell membrane stiffness and interaction ..
  79. ncbi Contribution of bradykinin and nitric oxide to AT2 receptor-mediated differentiation in PC12 W cells
    Yi Zhao
    Institute of Pharmacology, Christian Albrechts University of Kiel, Kiel, Germany
    J Neurochem 85:759-67. 2003
    ..The effects of angiotensin II on cell differentiation and cyclic GMP production were mediated via the AT2 receptor and further enhanced by bradykinin B2 receptor blockade.
  80. ncbi Inhibitory effect of a novel bradykinin B1 receptor antagonist, R-954, on enhanced vascular permeability in type 1 diabetic mice
    Bryan Simard
    Institute of Pharmacology of Sherbrooke, School of Medicine, University of Sherbrooke, Sherbrooke, PQ J1H 5N4, Canada
    Can J Physiol Pharmacol 80:1203-7. 2002
    ..Normally absent in physiological conditions, the bradykinin B1 receptor (BKB1-R) was recently found to be overexpressed in pathological conditions, including type 1 ..
  81. ncbi Bradykinin-induced cell migration and COX-2 production mediated by the bradykinin B1 receptor in glioma cells
    Dah Yuu Lu
    Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taichung, Taiwan
    J Cell Biochem 110:141-50. 2010
    b>Bradykinin is produced and acts at the site of injury and inflammation. Recent reports have also shown that bradykinin selectively modulates blood-tumor barrier permeability...
  82. ncbi P2X3 and P2X2/3 receptors mediate mechanical hyperalgesia induced by bradykinin, but not by pro-inflammatory cytokines, PGE₂ or dopamine
    Maria Cláudia Gonçalves de Oliveira Fusaro
    Department of Physiological Sciences, Piracicaba Dental School, State University of Campinas UNICAMP, Limeira Av 901, 13414 900 Piracicaba, Sao Paulo, Brazil
    Eur J Pharmacol 649:177-82. 2010
    ..induced by the inflammatory mediators involved in carrageenan-induced mechanical hyperalgesia, such as bradykinin, tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), chemokine-induced ..
  83. ncbi Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisites
    Leanid Luksha
    Institution for Clinical Science, Intervention and Technology, Department of Obstetrics and Gynecology, Karolinska Institute, Karolinska University Hospital Huddinge Campus, 14186 Stockholm, Sweden
    Am J Physiol Regul Integr Comp Physiol 294:R510-9. 2008
    ..With the use of wire myography, responses to the endothelium-dependent agonist bradykinin (BK) were determined before and after inhibition of pathways relevant to EDHF activity...
  84. ncbi Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch
    Miwa Hosogi
    Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Pain 126:16-23. 2006
    Histamine, substance P, serotonin and bradykinin were applied by iontophoresis to lesional and visually non-lesional skin of 14 patients with atopic dermatitis, and normal skin of 15 healthy volunteers...
  85. ncbi The bradykinin B2 receptor in the early immune response against Listeria infection
    Wendy E Kaman
    TNO Defence, Security and Safety, Business Unit Biological and Chemical Protection, 2280 AA, Rijswijk, The Netherlands
    Med Microbiol Immunol 198:39-46. 2009
    The endogenous danger signal bradykinin was recently found implicated in the development of immunity against parasites via dendritic cells...
  86. ncbi Bradykinin and the pathophysiology of angioedema
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Maggiore Hospital, Via Pace, 15, 20122 Milan, Italy
    Int Immunopharmacol 3:311-7. 2003
    Angioedema has different causes and different clinical presentations. Some types of angioedema may be mediated by bradykinin. We measured plasma levels of bradykinin-(1-9)nonapeptide by radioimmunoassay after high-performance liquid ..
  87. ncbi Bradykinin enhances GLUT4 translocation through the increase of insulin receptor tyrosine kinase in primary adipocytes: evidence that bradykinin stimulates the insulin signalling pathway
    S Isami
    Department of Metabolic Medicine, Kumamoto University School of Medicine, Japan
    Diabetologia 39:412-20. 1996
    It has been suggested that bradykinin stimulates glucose uptake in experiments in vivo and in cultured cells. However, its mechanism has not yet been fully elucidated...
  88. ncbi Selective tumor blood-brain barrier opening with the kinin B2 receptor agonist [Phe(8)psi(CH(2)NH)Arg(9)]-BK in a F98 glioma rat model: an MRI study
    Jérôme Côté
    Department of Nuclear Medicine and Radiobiology, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4
    Neuropeptides 44:177-85. 2010
    ..One approach for transporting drugs across the BBB involves the activation of bradykinin-B2 receptors (BK-B2R)...
  89. ncbi Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice
    Duncan J Campbell
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Hypertension 43:854-9. 2004
    ..We also measured the levels of bradykinin (1-9) and its ACE metabolite bradykinin (1-7)...
  90. ncbi Bradykinin augments insulin-stimulated glucose transport in rat adipocytes via endothelial nitric oxide synthase-mediated inhibition of Jun NH2-terminal kinase
    Kristin M Beard
    Department of Medicine and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X6
    Diabetes 55:2678-87. 2006
    An increase in bradykinin has been suggested to contribute to the enhanced insulin sensitivity observed in the presence of ACE inhibitors...
  91. ncbi Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice
    Arpád Szabó
    Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs 7624, Szigeti u 12, Hungary
    J Pharmacol Exp Ther 314:111-9. 2005
    ..with the lipoxygenase inhibitor nordihydroguaretic acid (NDGA), the cyclooxygenase inhibitor indomethacin, the bradykinin B2 receptor antagonist HOE-140 [D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thyenyl)-L-..
  92. ncbi Bradykinin inhibits high glucose- and growth factor-induced collagen synthesis in mesangial cells through the B2-kinin receptor
    Nelly Blaes
    INSERM U1048, Institut des Maladies Métaboliques et Cardiovasculaires I2MC, Universite Paul Sabatier, Toulouse cedex France
    Am J Physiol Renal Physiol 303:F293-303. 2012
    ..A beneficial effect is achieved with angiotensin I-converting enzyme inhibitors (ACEI), which also favor bradykinin (BK) B2 receptor (B2R) activation...
  93. pmc Activation of TRPV1 by capsaicin induces functional kinin B(1) receptor in rat spinal cord microglia
    Sébastien Talbot
    Department of Physiology, Faculty of Medicine, Universite de Montreal, C, P, 6128, Succursale Centre Ville, Montreal, H3C 3J7, Quebec, Canada
    J Neuroinflammation 9:16. 2012
    ..To examine the link between TRPV1 and B(1)R in inflammatory pain, this study aimed to determine the ability of TRPV1 to regulate microglial B(1)R expression in the spinal cord dorsal horn, and the underlying mechanism...
  94. ncbi Effect of angiotensin-(1-7) and bradykinin in patients with heart failure treated with an ACE inhibitor
    A P Davie
    Medical Research Council Clinical Research Initiative in Heart Failure, University of Glasgow, Glasgow, UK
    Hypertension 34:457-60. 1999
    ..processing that has been proposed to have vasodepressor effects, both on its own and in combination with bradykinin, which may be pathophysiologically and therapeutically important...
  95. ncbi Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists
    Sakonwun Sangsree
    Department of Pharmacology, University of Illinois College of Medicine, Chicago 60612, USA
    Am J Physiol Heart Circ Physiol 284:H1959-68. 2003
    ..b>Bradykinin (1-100 nM) elicited a transient (5 min) peak of generation of NO that was blocked by the B(2) antagonist HOE 140,..
  96. ncbi Bradykinin protects against brain microvascular endothelial cell death induced by pathophysiological stimuli
    Veronica Bovenzi
    Department of Pharmacology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Cell Physiol 222:168-76. 2010
    ..Angiotensin converting enzyme inhibitors (ACEi), which are known to favor bradykinin (BK) bioactivity by reducing its metabolism, may have a positive impact on preventing the microvascular ..
  97. ncbi Bradykinin and other inflammatory mediators in BAL-fluid from patients with active pulmonary inflammation
    C R Baumgarten
    Dept of Clinical Immunology and Asthma Poliklinik, Free University, Berlin, Germany
    Agents Actions Suppl 38:475-81. 1992
    We evaluated the levels of bradykinin, albumin, TAME-esterase activity, histamine, PGD2 and LTC4 in bronchoalveolar lavage fluid from asthmatics and from patients with pneumonia, sarcoidosis, fibrosis, and chronic bronchitis...
  98. ncbi Interleukin-4 increases murine airway response to kinins, via up-regulation of bradykinin B1-receptors and altered signalling along mitogen-activated protein kinase pathways
    M Bryborn
    Laboratory of Clinical and Experimental Allergy, Department of Otorhinolaryngology, Malmo University Hospital, Lund University, Malmo, Sweden
    Clin Exp Allergy 34:1291-8. 2004
    ..IL-4 is believed to play a role in asthma and chronic obstructive pulmonary disease through promotion of eosinophilic inflammation and mucus hypersecretion. Whether IL-4 can induce a direct effect on airway smooth muscle remains unknown...
  99. ncbi Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part I. Classification, epidemiology, pathophysiology, genetics, clinical symptoms, and diagnosis
    T Caballero
    Servicio de Alergia, Hospital La Paz Health Research Institute IdiPAZ, Madrid, Spain
    J Investig Allergol Clin Immunol 21:333-47; quiz follow 347. 2011
    There are no Spanish guidelines or consensus statement on bradykinin-induced angioedema.
  100. pmc Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts
    F Bellucci
    Department of Pharmacology, Menarini Ricerche SpA, Florence, Italy
    Br J Pharmacol 158:1996-2004. 2009
    b>Bradykinin (BK) and B2 receptors have been implicated in the pathophysiology of osteoarthritis (OA), and synovitis is one of its hallmarks...
  101. ncbi Acute antihypertrophic actions of bradykinin in the rat heart: importance of cyclic GMP
    Anke C Rosenkranz
    Howard Florey Institute, Parkville, Victoria, Australia
    Hypertension 40:498-503. 2002
    ..of angiotensin (Ang)-converting enzyme (ACE) inhibitors in the heart is attributed in part to potentiation of bradykinin. Bradykinin prevents hypertrophy of cultured cardiomyocytes by releasing nitric oxide (NO) from endothelial ..

Research Grants65

  1. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..carboxypeptidase B (CPB or TAFIa) plays a broad anti-inflammatory role in vivo;the targets for CPB include bradykinin, C5a, the generation of plasmin and thrombin-cleaved osteopontin (OPN-Arg or OPN-R)...
  2. The Kallikrein/Kinin-Mast Cell Interaction in Volume Overload
    CHIH CHANG KEVIN WEI; Fiscal Year: 2013
    ..therapy with angiotensin-converting enzyme (ACE) inhibitors, which decreases angiotensin II and increases bradykinin (BK), is ineffective in a pathophysiologic LV VO (1)...
  3. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ..such as HNE on neurogenic pancreatic inflammation and nociception, to determine how the pro-inflammatory peptide bradykinin sensitizes TRPA1, and to investigate the contribution of TRPA1 to neurogenic inflammation and pain in several ..
  4. Role of the kallikrein-kinin system in diabetic retinopathy
    Edward P Feener; Fiscal Year: 2012
    ..CA-I-induced retinal edema was decreased by complement 1 inhibitor, neutralizing antibody to prekallikrein, and bradykinin receptor antagonism...
  5. The Role of Carboxypeptidase B and its Substrates in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2013
    ..Recently, C3a, C5a, thrombin-cleaved osteopontin (OPN-R) and bradykinin were identified as additional substrates of CPB...
  6. The Role of Vascular Innervation on Tissue-type Plasminogen Activator Release
    JAMES ANTHONY SHEERIN MULDOWNEY; Fiscal Year: 2013
    ..to numerous neurohormones including acetylcholine, catecholamines, substance P, arginine vasopressin and bradykinin. Physiologic release of t-PA is deleteriously altered by modifiable cardiac risk factors such as smoking, ..
  7. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..that stimulate primary sensory neurons include hydrogen ions, heat, leukotrienes, arachidonic acid metabolites, bradykinin, and proteases such as trypsin, all of which may participate in the generation of acute pancreatitis...
  8. Prolylcarboxypeptidase is a Risk Factor for Cardiovascular Disease
    Alvin H Schmaier; Fiscal Year: 2013
    ..PRCP degrades angiotensin II (AngII) and bradykinin 1-8...
  9. Inducible Dysplastic Nephropathy in B2-Deficient Mice
    Samir S El-Dahr; Fiscal Year: 2013
    ..We previously demonstrated that bradykinin B2 receptor-null (BdkrB2-/-) embryos exposed to gestational salt stress develop renal dysgenesis as a result of ..
  10. Mechanism and functional role of AKAP79/150 in M current control
    Mark S Shapiro; Fiscal Year: 2012
    ..in NG neurons by a variety of Gq/11-linked receptor types that are critical to pain and inflammation, including bradykinin, PAR-2, histamine, angiotensin II and purinergic receptors...
  11. Mechanisms of Cardiac Afferents and CNS Reflex Processing
    John C Longhurst; Fiscal Year: 2013
    ..These include bradykinin (BK), reactive oxygen species, protons, cyclooxygenase metabolites, serotonin (5HT), histamine, and most ..
  12. Preclinical Development of a Novel and Effective Treatment for Cough
    Blake M Paterson; Fiscal Year: 2011
    ..Using in vivo methods, we will evaluate the potency, efficacy and duration of action of MMT against bradykinin, capsaicin and citric acid-induced cough, compared to DXM and codeine...
  13. Bacterial peptidylarginine deiminase, a link between gums and joint disease
    JAN S POTEMPA; Fiscal Year: 2013
    ..by modifying important effector molecules of the innate immunity, including C3a and C5a anaphylatoxins and bradykinin. Biological activity of these peptides depends on the C-terminal arginine, which is also a preferential target ..
  14. Excitability of afferents evoking the exercise pressor reflex
    Victor Ruiz-Velasco; Fiscal Year: 2013
    ..In both in vitro and in vivo experiments, particular attention will be paid to the effects two peptides, namely bradykinin and DAMGO, on the membrane and discharge properties of the afferents...
  15. Dual role of the bradykinin B2 receptor during inflammation
    Bruce L Zuraw; Fiscal Year: 2013
    ..potent anti-asthma actions in both experimental animals and human asthmatic subjects, mice lacking the bradykinin B2 receptor (B2R) exhibit enhanced bronchial hyperresponsiveness, inflammation, and airway remodeling in the OVA ..
  16. Regulation of Angiogenesis by Kininogen
    Keith R McCrae; Fiscal Year: 2013
    ..This has been attributed to deficient release of bradykinin (BK) from single chain high molecular weight kininogen (HK), leading to diminished activation of stromal BK B2 ..
  17. Role of the Bradykinin Pathway in Craniofacial Development
    LAURA ANNE JACOX; Fiscal Year: 2013
    ..The Bradykinin pathway, previously described only in adults, is locally necessary in the EAD, for mouth formation...
  18. Role of Endothelin System and NAD(P)H Oxidase in Retinal Arteriolar Dysfunction
    Travis W Hein; Fiscal Year: 2012
    ..Our preliminary studies showed that retinal ischemia via elevated intraocular pressure (IOP) impaired bradykinin-induced NO-mediated dilation and enhanced ET-1-mediated constriction in pig retinal arterioles...
  19. Role of Chymase In The Post-Myocardial Infarction Heart
    Ahsan Husain; Fiscal Year: 2013
    ..This is supported by the finding that ACE inhibition causes bradykinin/kinin B2 receptor-mediated release of mouse mast cell protease (MMCP)-4 (functional homolog of human chymase) in ..
  20. Targeting crosstalk between insulin and Gq signaling systems in pancreatic cancer
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ..cellular events, such as increase in [Ca2+]i elicited by Gq-coupled receptor agonists, including angiotensin II, bradykinin, bombesin and neurotensin...
  21. gC1q-R/P33: Structure-function and role in inflammation
    Berhane Ghebrehiwet; Fiscal Year: 2012
    ..This in turn leads to the generation of bradykinin, a potent vasoactive peptide involved in various inflammatory processes including angioedema, hypotension, ..
  22. p66/Insulin Like Growth Factor-1 Reno-Protection in Diabetes
    LEONARD GERALD MEGGS; Fiscal Year: 2010
    ..Mutations at the bradykinin 1 and 2 receptor loci (B1/B2-/-) have been reported to increase the risk and severity of DG and aging phenotypes ..
  23. Prevention of Diabetic Neuropathy with ACE Inhibitors
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..NEP degrades natriuretic peptides as well as neuropeptides such as calcitonin gene-related peptide (CGRP) and bradykinin. Our working hypothesis is that vascular dysfunction contributes significantly to DN and that successful ..
  24. Fast calcium responses along arteriolar endothelium in vivo
    Pooneh Bagher; Fiscal Year: 2010
    ..g. ACh, bradykinin, substance P, and ATP)...
  25. Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Raouf A Khalil; Fiscal Year: 2010
    ..Expression of vascular NOS and COX, and the AT2R-induced bradykinin release, nitrite/nitrate and PGI2 production, and membrane potential will be measured...
  26. Neuroendocrine-modulated epithelial HCO3- transport
    Bruce D Schultz; Fiscal Year: 2013
    ..Norepinephrine and adenosine stimulate PKA whereas oxytocin stimulates PKC to achieve anion secretion. Bradykinin stimulates anion secretion by an undetermined mechanism that requires cyclooxygenase activity and the response ..
  27. Plasma kininogen and kininogen-cleaving proteases in arthritis
    Yi Wu; Fiscal Year: 2013
    ..In vitro, the active form of PK, FXII and FXI cleave HK to generate bradykinin and kinin-free HK (called as HKa). Both bradykinin and HKa possess multiple proinflammatory functions...
  28. Lipid Regulation of Transient Receptor Potential Channels
    Tibor Rohacs; Fiscal Year: 2013
    ..low-grade stimuli through activation of G-protein coupled receptors (GPCRs) by pro-inflammatory agents such as bradykinin. Sensitization plays an important role in thermal hyperalgesia, a disturbing symptom in neuropathic pain ..
  29. GENES AND FIBRINOLYTIC CAPACITY OF HUMAN ENDOTHELIUM
    Mias Pretorius; Fiscal Year: 2012
    ..During the last period of this grant we have determined that, in addition to stimulating t-PA release, bradykinin induces oxidative stress and inflammation in the human forearm vasculature and contributes to the fibrinolytic ..
  30. Exacerbation of pertussis airway inflammation and pathology by pertussis toxin
    Nicholas H Carbonetti; Fiscal Year: 2012
    ..We also have preliminary data that PT increases respiratory levels of the inflammatory mediator bradykinin, a peptide implicated in several airway pathologies including cough, and that PT exacerbates respiratory ..
  31. Estrogen regulation of inflammatory mediator signaling
    William P Clarke; Fiscal Year: 2011
    ..neurons and showed that estradiol rapidly (15 min) enhances cellular signaling by two inflammatory mediators, bradykinin (BK) and prostaglandin E2 (PGE2) in cultured TG neurons...
  32. Exacerbation of pertussis airway inflammation and pathology by pertussis toxin
    Nicholas H Carbonetti; Fiscal Year: 2013
    ..We also have preliminary data that PT increases respiratory levels of the inflammatory mediator bradykinin, a peptide implicated in several airway pathologies including cough, and that PT exacerbates respiratory ..
  33. Regulation of opioid receptor function in trigeminal ganglion
    William P Clarke; Fiscal Year: 2012
    ..time course for induction of competence, and the persistence of competence after induction, by administration of bradykinin (BK), arachidonic acid (AA) and naloxone...
  34. Therapeutic factor XI blockade for sepsis
    ERIK IAN contact TUCKER; Fiscal Year: 2010
    ..FXI inhibition may also be anti-inflammatory by reducing bradykinin liberation...
  35. Mitochondrial Dysfunction in Chronic Kidney Disease
    JORGE LUIS GAMBOA; Fiscal Year: 2013
    ..We have previously shown that bradykinin plays a role in inflammation in patients on HD and increases oxidative stress in vitro...
  36. KALLIKREIN KININ SYSTEM IN INFLAMMATORY BOWEL DISEASE
    Robert Colman; Fiscal Year: 2001
    ..plasma kallikrein which activates neutrophils, cleaves high molecular weight kininogen (HK) and releases bradykinin which induces pain, swelling, diarrhea, and muscle contraction, all of which are characteristic symptoms of ..
  37. Pro-inflammatory Mediator Crosstalk Induces COX-2 in Myofibroblasts via PKC/PKD
    James Yoo; Fiscal Year: 2013
    ..upregulation of COX-2 protein expression following treatment with the inflammatory mediators TNF-( (TNF) and bradykinin (BK)...
  38. ESTROGEN MODULATION OF HUMAN NOCICEPTORS
    Kenneth M Hargreaves; Fiscal Year: 2012
    ..neurons and in peripheral neurons in surgical biopsies, and discovered that estradiol significantly increases bradykinin/prostaglandin E2 (BK/PGE2)-evoked iSP from human tissue biopsies collected from women, but not from men...
  39. Antiotensin converting enzyme gene expression
    Ganes C Sen; Fiscal Year: 2012
    ..ACE is a dipeptidyl carboxypeptidase whose natural substrates include the oligopeptides angiotensin I and bradykinin. It has two isozymes, sACE and gACE, which have similar enzymatic activities but are expressed in a tissue-..
  40. Metabolite effects on Group III and IV afferents
    MARC PETER KAUFMAN; Fiscal Year: 2013
    ..metabolic stimuli will be investigated, namely lactic acid, ATP, a purine which stimulates P2 receptors, and bradykinin, a peptide that stimulates B2 receptors...
  41. Preconditioning Improves Coronary Patency
    Karin Przyklenk; Fiscal Year: 2012
    ..e., adenosine and bradykinin) acting at multiple sites (receptors on neutrophils as well as platelets)...
  42. Innate Immunity in Experimental Arthritis of Kininogen
    Robert Colman; Fiscal Year: 2007
    ..weight kininogen (HK), which is required for activation of plasma kallikrein, is the substrate for release of bradykinin and will modulate the acute and chronic arthritis and systemic inflammation produced by PG-APS in genetically ..
  43. Mechanosensitivity of Cell Membranes: Role of Lipid-Protein Interactions
    Mirianas Chachisvilis; Fiscal Year: 2012
    ..lateral fluidity and hydration levels change and (2) that increases in membrane tension lead to activation of bradykinin G protein coupled receptor (GPCR)...
  44. NEW MODALITIES FOR TREATMENT OF PAIN AND DRUG ABUSE
    Victor J Hruby; Fiscal Year: 2013
    ..Design and synthesis of novel dynorphin A non-opioid ligands that act at a putative novel binding site on bradykinin receptors;6) Synthesize bivalent novel ligands that are mu/delta receptor agonists/bradykinin receptor ..
  45. Preeclampsia and Autoimmunity
    Rodney E Kellems; Fiscal Year: 2012
    ..Do AT1-AAs contribute to AT1 receptor heterodimerization with the bradykinin B2 receptor? If AT1-AAs play a major role in the pathophysiology of preeclampsia, as we hypothesize, it should ..
  46. Aldosterone-independent regulation of ENaC by systemic salt
    Oleh Pochynyuk; Fiscal Year: 2013
    ..Specifically, we have developed evidence that coordinated coupling between stimulatory Ang II and inhibitory Bradykinin (BK) cascades is necessary for proper adaptation of ENaC activity to variations in dietary sodium...
  47. Signaling in Living Cells
    NARASIMHAN GAUTAM; Fiscal Year: 2013
    ..found that secretion of cathepsin D, a protease that promotes tumor growth and metastasis, is regulated by a bradykinin receptor. Insulin secretion is also known to be regulated by GPCRs, including the M3 muscarinic receptor...
  48. Cerebrovascular Afferent Mechanisms of Migraine
    ANDREA MARIE HARRIOTT; Fiscal Year: 2010
    ..Evidence suggests that inflammatory mediators such as histamine, bradykinin, and prostaglandin sensitize cerebrovascular afferents...
  49. Mouse Models of Functional Insertion Polymorphisms
    Kathleen H Burns; Fiscal Year: 2013
    ..blood pressure control system and is also involved in vascular homeostasis through degradation of bradykinin;the Alu is a well-studied marker of reduced ACE enzyme levels and presumed to be functional, although this has ..
  50. Bradykinin, Nitric Oxide and Mitochondrial DNA Damage in Diabetic Complications
    Oliver Smithies; Fiscal Year: 2010
    ..by applicant): In our previous work we have demonstrated that genetic factors controlling the production of bradykinin (BK) and nitric oxide (NO) influence greatly the development of renal complications in mice made diabetic with ..
  51. Application of QDs-based nanotyping technology in the evaluation of chemotherapy
    Y Andrew Wang; Fiscal Year: 2010
    ..Specifically, activation of the anti-apoptotic bradykinin-survivin signaling pathway was found to be critical to Docetaxel (Taxotere) resistance in prostate cancer cells, ..
  52. Mechanisms of Diabetic Renal Damage: Role of the Kinin Receptors
    Parker C Wilson; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bradykinin receptors (B1, B2) are GPCRs that have been implicated in the proliferative and fibrotic response that characterizes diabetic nephropathy...
  53. Sensory C Fibers in the Upper Airways
    THOMAS EDWARD TAYLOR-CLARK; Fiscal Year: 2011
    ..g. bradykinin B2 receptors)...
  54. RAS and Injury
    Kenneth E Bernstein; Fiscal Year: 2013
    ..Angiotensin I and bradykinin are well known ACE substrates, but the enzyme also cleaves several other peptides...
  55. Radiation-Induced Heart Disease: Mechanisms and Interventions
    Marjan Boerma; Fiscal Year: 2013
    ..Proteinase-Activated Receptor (PAR)-2, the receptor that mediates cellular effects of mast cell proteinases;2) bradykinin, a cardioprotective hormone that is formed by mast cell proteinases;and 3) the cardioprotective sensory ..
  56. INTERACTIONS OF TRPV1 AND TRPA1 AND INFLAMMATORY PAIN
    Armen N Akopian; Fiscal Year: 2010
    ..the sensitization of the TRPA1-mediated responses by protein kinase C (PKC) and an inflammatory mediator bradykinin in sensory neurons...
  57. EFFECTS OF ETHANOL ON PHOSPHOLIPASE D MEDIATED SIGNALING
    Joel Horwitz; Fiscal Year: 2003
    ..In cells exposed to ethanol chronically, stimulation of phospholipase D by bradykinin (BK) and other agents is greatly attenuated, whereas activation of phospholipase C by BK is not altered...
  58. BRADYKININ VASCULAR INFLUENCE AND ACE INHIBITION
    BEN ZIMMERMAN; Fiscal Year: 1993
    ..BP and RBF, by electroflowmetry, will be monitored, plasma renin activity determined, and the effects of bradykinin antagonist, DArg(Hyp3,DPhe7) bradykinin (NPY 567) and new nonpeptide All antagonist (DUP 753) or saralasin ..
  59. Glioma-Astrocyte Vascular Interactions
    Harald W Sontheimer; Fiscal Year: 2013
    ..In a recent study, we show that glioma cells are attracted to cerebral vessels by responding to bradykinin which is produced by vascular endothelial cells...
  60. Clinical Impact of Bradykinin Receptor Polymorphisms
    James Gainer; Fiscal Year: 2005
    The bradykinin type 2 receptor (B2) mediates virtually all of the known effects of the kallikrein-kinin system on vascular, renal, and cardiovascular homeostasis...
  61. BRADYKININ RECEPTOR STUDIES--IMMUNOLOGICAL APPROACHES
    CHARLES ODYA; Fiscal Year: 1992
    ..The application focuses on the bradykinin (BK) receptor component of this system...
  62. BRONCHIAL CIRCULATION AND LUNG FLUID BALANCE
    George Kramer; Fiscal Year: 1993
    ..Inflammatory mediators, e.g. histamine, bradykinin, and substance P, alter the ultrastructure and selectively increase the permeability of bronchial venules while ..
  63. ACTIVATION OF PROTEIN KINASE C IN VASCULAR SMOOTH MUSCLE
    Bradley Dixon; Fiscal Year: 1993
    ..Preliminary studies have demonstrated that the vasodilator, bradykinin and the vasoconstrictor, angiotensin II, both increase intracellular calcium and diacylglycerol formation ..
  64. KININ REGULATION OF COLLECTING DUCT H+ EFFLUX
    YURII MUKHIN; Fiscal Year: 2002
    ..One of my mentors, David Ploth, recently established the putative presence of functional luminal bradykinin receptors in the collecting ducts of rats...
  65. ANTI ANGIOGENIC ACTIVITY OF CLEAVED HMW KININOGEN
    Keith McCrae; Fiscal Year: 2004
    ..Cleavage of HK to HKa leads to the release of bradykinin, and is accompanied by a dramatic structural arrangement...