angiotensins

Summary

Summary: Oligopeptides ranging in size from angiotensin precursors with 14 amino acids to the active vasoconstrictor angiotensin II with 8 amino acids, or their analogs or derivatives. The amino acid content varies with the species and changes in that content produce antagonistic or inactive compounds.

Top Publications

  1. pmc Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examination
    Daniel Keizman
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Eur J Cancer 47:1955-61. 2011
  2. ncbi A new look at the renin-angiotensin system--focusing on the vascular system
    Aurelie Nguyen Dinh Cat
    Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
    Peptides 32:2141-50. 2011
  3. pmc Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart
    Paul J Garabelli
    The Hypertension and Vascular Disease Center, Winston Salem, NC, USA
    Exp Physiol 93:613-21. 2008
  4. ncbi Effect of extracellular and intracellular angiotensins on heart cell function; on the cardiac renin-angiotensin system
    Walmor De Mello
    Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, PO Box 365067, San Juan, PR 00936 5067, USA
    Regul Pept 114:87-90. 2003
  5. ncbi Blockade of pro-cognitive effects of angiotensin IV and physostigmine in mice by oxytocin antagonism
    Paul R Gard
    School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton, BN2 4GJ, UK
    Eur J Pharmacol 683:155-60. 2012
  6. ncbi Adrenal, kidney, and heart angiotensins in female murine Ren-2 transfected hypertensive rats
    P S Senanayake
    Eye Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Peptides 19:1685-94. 1998
  7. ncbi Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors
    M M van den Eijnden
    Cardiovascular Research Institute COEUR, Department of Pharmacology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 21:911-6. 2001
  8. pmc Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis rats
    Karl D Pendergrass
    Hypertension and Vascular Disease Ctr, Wake Forest Univ Health Sciences, Winston Salem, NC 27157 1095, USA
    Am J Physiol Heart Circ Physiol 295:H10-20. 2008
  9. pmc Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen
    Amy C Arnold
    Hypertension and Vascular Research Center and Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Hypertension 51:1326-31. 2008
  10. ncbi Evidence for the role of angiotensin II biosynthesis in the rat internal anal sphincter tone
    Marcio A F de Godoy
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 127:127-38. 2004

Research Grants

Detail Information

Publications229 found, 100 shown here

  1. pmc Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examination
    Daniel Keizman
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Eur J Cancer 47:1955-61. 2011
    ..Data suggests that they may inhibit tumourigenesis...
  2. ncbi A new look at the renin-angiotensin system--focusing on the vascular system
    Aurelie Nguyen Dinh Cat
    Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
    Peptides 32:2141-50. 2011
    ..The present review highlights recent progress in the RAS field, focusing on the tissue system and particularly on the vascular RAS...
  3. pmc Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart
    Paul J Garabelli
    The Hypertension and Vascular Disease Center, Winston Salem, NC, USA
    Exp Physiol 93:613-21. 2008
    ..We determined the metabolism of angiotensins in wild-type (WT), ACE (ACE(-/-)) and ACE2 null mice (ACE2(-/-))...
  4. ncbi Effect of extracellular and intracellular angiotensins on heart cell function; on the cardiac renin-angiotensin system
    Walmor De Mello
    Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, PO Box 365067, San Juan, PR 00936 5067, USA
    Regul Pept 114:87-90. 2003
    In this manuscript, I presented up-to-date evidence that intracellular and extracellular angiotensins have an important regulatory effect on the processes of heart cell communication and inward calcium current and that aldosterone ..
  5. ncbi Blockade of pro-cognitive effects of angiotensin IV and physostigmine in mice by oxytocin antagonism
    Paul R Gard
    School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton, BN2 4GJ, UK
    Eur J Pharmacol 683:155-60. 2012
    ....
  6. ncbi Adrenal, kidney, and heart angiotensins in female murine Ren-2 transfected hypertensive rats
    P S Senanayake
    Eye Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Peptides 19:1685-94. 1998
    ..In SD and transgenic rats kidney and adrenal angiotensins increased primarily during estrus or proestrus...
  7. ncbi Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors
    M M van den Eijnden
    Cardiovascular Research Institute COEUR, Department of Pharmacology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 21:911-6. 2001
    ..Most likely, therefore, in the absence of angiotensinogen synthesis or endocytosis, M6P receptor-mediated prorenin internalization by endothelial cells represents prorenin clearance...
  8. pmc Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis rats
    Karl D Pendergrass
    Hypertension and Vascular Disease Ctr, Wake Forest Univ Health Sciences, Winston Salem, NC 27157 1095, USA
    Am J Physiol Heart Circ Physiol 295:H10-20. 2008
    ..The enhanced activity of the RAAS in male congenics may contribute to the higher pressure and tissue injury evident in the strain...
  9. pmc Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogen
    Amy C Arnold
    Hypertension and Vascular Research Center and Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Hypertension 51:1326-31. 2008
    ..These results suggest a novel mechanism for the preservation of baroreflex sensitivity during aging...
  10. ncbi Evidence for the role of angiotensin II biosynthesis in the rat internal anal sphincter tone
    Marcio A F de Godoy
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Gastroenterology 127:127-38. 2004
    ..The internal anal sphincter tone is important for anorectal continence. This study examined the role of angiotensin II as a neurohumoral signal for the myogenic tone in the internal anal sphincter...
  11. ncbi Brain renin-angiotensin--a new look at an old system
    John W Wright
    Department of Psychology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
    Prog Neurobiol 95:49-67. 2011
    ..of an independent local brain RAS composed of the necessary functional components (angiotensinogen, peptidases, angiotensins and specific receptor proteins) significantly expanded the possible physiological and pharmacological functions ..
  12. pmc Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy
    Carlos M Ferrario
    The Hypertension and Vascular Research Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 296:H1184-92. 2009
    ..Nephrectomy yielded divergent effects on circulating and cardiac angiotensins. Significant decreases in plasma ANG-(1-12), ANG I, and ANG II levels postnephrectomy accompanied increases in ..
  13. ncbi Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart
    Aaron J Trask
    Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 294:H2242-7. 2008
    ..This finding further suggests that this angiotensinogen-derived product is a previously unrecognized important precursor peptide to the renin-angiotensin system cascade...
  14. ncbi Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II
    Hossam A Shaltout
    Department of Obstetrics and Gynecology, Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1095, USA
    Am J Physiol Renal Physiol 292:F82-91. 2007
    ..Therefore, we investigated the metabolism of the angiotensins in isolated proximal tubules, urine, and serum from sheep...
  15. ncbi Body mass index and angiotensin-dependent control of the renal circulation in healthy humans
    Sofia B Ahmed
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 46:1316-20. 2005
    ..Weight loss should be considered in the overweight or obese patient for renal protection...
  16. pmc New angiotensins
    Jasmina Varagic
    The Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Mol Med (Berl) 86:663-71. 2008
    ..This review focuses on angiotensin-(1-7) and its important contribution to cardiovascular function and growth, while introducing angiotensin-(1-12) as a potential novel angiotensin precursor...
  17. ncbi Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor
    Wendy W Batenburg
    Erasmus MC, Rotterdam, The Netherlands
    J Hypertens 25:2441-53. 2007
    ..Here, we evaluated the kinetics of renin/prorenin binding to the recently discovered human (pro)renin receptor (h(P)RR), and the idea that such binding underlies tissue angiotensin generation...
  18. ncbi Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis
    Adam Kretowski
    Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
    Diabetes 56:863-71. 2007
    ....
  19. ncbi The effect of angiotensin 1-7 on tyrosine kinases activity in rat anterior pituitary
    Elzbieta Rebas
    Department of Molecular Neurochemistry, Medical University of Lodz, Poland
    Biochem Biophys Res Commun 347:581-5. 2006
    ..The presence of PD123319 together with Ang 1-7 caused stronger inhibition PTKs activity than Ang 1-7 alone. These observations suggest that Ang 1-7 binds to the novel, unknown, specific for this peptide receptor...
  20. ncbi The involvement of angiotensins in the control of prostatic epithelial cell proliferation in the rat
    M Pawlikowski
    Department of Experimental Endocrinology and Hormone Diagnostics, Institute of Endocrinology, , Poland
    Folia Histochem Cytobiol 39:341-3. 2001
    The effects of captopril (the inhibitor of the angiotensin-converting enzyme) and of angiotensins II and IV (3-8 fragment of angiotensin II) on cell proliferation of the prostatic epithelium was investigated in the rat...
  21. pmc Renin, angiotensins, and angiotensin-converting enzyme in neuroblastoma cells: evidence for intracellular formation of angiotensins
    T Okamura
    Proc Natl Acad Sci U S A 78:6940-3. 1981
    ..19), angiotensin-converting enzyme (dipeptidyl carboxypeptidase; peptidyldipeptide hydrolase, EC 3.4.15.1), and angiotensins I and II...
  22. pmc Overexpression of the local bone marrow renin-angiotensin system in acute myeloid leukemia
    Yavuz Beyazit
    Department of Internal Medicine, Hacettepe University Medical School, Ankara, Turkey
    J Natl Med Assoc 99:57-63. 2007
    ..The aim of this study is therefore to search those major RAS components simultaneously in the leukemic blast cells taken from the bone marrow of patients with acute myeloid leukemia (AML)...
  23. ncbi Angiotensins in Alzheimer's disease - friend or foe?
    Patrick G Kehoe
    Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, UK
    Trends Neurosci 32:619-28. 2009
    ..This paper reviews molecular, genetic, experimental and clinical data as well as the therapeutic opportunities that relate to the involvement of the RAS in AD...
  24. ncbi Urinary vasodilator and vasoconstrictor angiotensins during menstrual cycle, pregnancy, and lactation
    G Valdes
    Departamento de Nefrologia, Centro de Investigaciones Medicas, Pontificia Universidad Catolica, Santiago, Chile
    Endocrine 16:117-22. 2001
    ..49,p < 0.001). The progressive rise of Ang-(1-7) throughout gestation, probably modulated by estrogen and progesterone, suggests a physiologic counterregulation within the RAAS...
  25. ncbi Intrauterine growth restriction in rats is associated with hypertension and renal dysfunction in adulthood
    Marie Claude Battista
    Research Center, Hôpital Sainte Justine and Department of Obstetrics and Gynecology, Universite de Montreal, Montreal, Quebec, Canada H3T 1C5
    Am J Physiol Endocrinol Metab 283:E124-31. 2002
    ..Differences observed between male and female adults suggest the importance of gender in outcomes in adulthood after IUGR...
  26. ncbi Historical perspective of the renin-angiotensin system
    John E Hall
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Mol Biotechnol 24:27-39. 2003
    ....
  27. ncbi The renin-angiotensin and the kallikrein-kinin systems
    Duncan J Campbell
    St Vincent s Institute of Medical Research, Fitzroy, VIC 3065, Australia
    Int J Biochem Cell Biol 35:784-91. 2003
    ..Both angiotensin and kinin peptides are metabolised by many different peptidases that are important determinants of the activities of the RAS and KKS, and several of which participate in both systems...
  28. ncbi Tissue renin-angiotensin system and end-organ damage
    Friedrich C Luft
    Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
    J Mol Med (Berl) 80:325-6. 2002
  29. ncbi Effect of dietary sodium intake on central angiotensinergic pathways
    Gerald F DiBona
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Auton Neurosci 98:17-9. 2002
    ..These observations support the view that physiologically regulated angiotensin peptides of the brain origin exert a local paracrine or autocrine action on sites that influence the renal sympathetic nerve activity...
  30. ncbi Mechanism of increased angiotensin II levels in glomerular mesangial cells cultured in high glucose
    Rekha Singh
    Department of Medicine, Veterans Affairs Hospital, Hines, Illinois, and Loyola University Stritch School of Medicine, Maywood, Illinois 60141, USA
    J Am Soc Nephrol 14:873-80. 2003
    ..In addition, this study provides new information that Ang(1-9) is produced by mesangial cells, can be converted to AngII, and that this conversion is also stimulated under high-glucose conditions...
  31. ncbi Differentiation in the effects of the angiotensin II receptor blocker class on autonomic function
    Murray Esler
    Baker Medical Research Institute, Commercial Road, Prahran 3181, Melbourne, Australia
    J Hypertens Suppl 20:S13-9. 2002
    ..A reduction in noradrenaline spillover disproportionate to any possible fall in nerve firing would document the presence of presynaptic antagonism of noradrenaline release...
  32. ncbi Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 rat
    Jennifer L Wilkinson-Berka
    Department of Physiology, The University of Melbourne, Grattan Street, Parkville 3010, Victoria, Australia
    Mol Cell Endocrinol 194:201-9. 2002
    ..In conclusion, macrophages and epithelial cells are the source of active renin in the rat thymus. The thymic RAS may have actions systemically and may also influence local processes such as blood flow and cell growth...
  33. ncbi Renin-angiotensin gene polymorphism in children with uremia and essential hypertension
    Ferenc Papp
    Department of Pediatrics, University of Szeged, Koranyi fasor 14 15, 6720 Szeged, Hungary
    Pediatr Nephrol 18:150-4. 2003
    ..Furthermore, there was a significant increase in MT genotype frequency of ANG M235T polymorphism in pediatric ESRD and JEHT. The role of AT1R gene polymorphism needs further investigation...
  34. ncbi Prorenin uptake in the heart: a prerequisite for local angiotensin generation?
    A H Jan Danser
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    J Mol Cell Cardiol 34:1463-72. 2002
    ..e., immediate binding of angiotensin II to its receptors with minimal loss into the extracellular space...
  35. ncbi Organisation and functional role of the brain angiotensin system
    Catherine Llorens-Cortes
    Institut National de la Sante et de la Recherche Medicale, Paris, France
    J Renin Angiotensin Aldosterone Syst 3:S39-48. 2002
  36. ncbi Left ventricular isovolumic relaxation and renin-angiotensin system in the growth restricted fetus
    Pavel B Tsyvian
    Mother and Child Care Institute, Yekaterinburg, Russia
    Eur J Obstet Gynecol Reprod Biol 140:33-7. 2008
    ..To determine left ventricular isovolumic relaxation time (LV IRT) in normally developing and growth restricted fetuses (FGR) as an indicator of fetal cardiac afterload and neonatal systolic blood pressure...
  37. ncbi New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy
    Daniel Batlle
    Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Curr Opin Nephrol Hypertens 17:250-7. 2008
    ....
  38. ncbi Diabetes and retinal vascular disorders: role of the renin-angiotensin system
    Jennifer L Wilkinson-Berka
    Department of Physiology, The University of Melbourne, Grattan St, Parkville, Victoria, Australia
    Expert Rev Mol Med 6:1-18. 2004
    ..This review examines the role of the RAS in diabetic retinopathy and retinopathy of prematurity, and the potential of RAS blockade as a treatment strategy for these vision-threatening diseases...
  39. ncbi Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivo
    Sebastien Fuchs
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Hypertension 51:267-74. 2008
    ..Although mice lacking C-domain activity have normal physiology under laboratory conditions, they respond less well to the stress of dehydration...
  40. ncbi [Renin-angiotensin system: molecular biology]
    J Zidzik
    Ustav lekárskej biológie, Lekárska fakulta UPJS, Kosice
    Cesk Fysiol 53:142-51. 2004
    ..RAS may take part in formation and progression of these diseases. In this work we focus on molecular biology of RAS and polymorphisms of RAS genes...
  41. ncbi Molecular evidence of tissue renin-angiotensin systems: a focus on the brain
    Koji Sakai
    Department of Internal Medicine and Physiology, 3181B Medical Education and Biomedical Research Facility, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Curr Hypertens Rep 7:135-40. 2005
    ..In this chapter, we review data demonstrating the existence and function of intrinsic tissue RAS, with a primary focus on the brain...
  42. ncbi [Renin-angiotensin system]
    Sadayoshi Ito
    Nihon Jinzo Gakkai Shi . 2007
  43. pmc Early renal denervation prevents development of hypertension in growth-restricted offspring
    Norma B Ojeda
    Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Clin Exp Pharmacol Physiol 34:1212-6. 2007
    ....
  44. ncbi [The renin-angiotensin system]
    Zuzana Husková
    Institut klinické a experimentální medicíny Pracoviste experimentální medicíny, Praha
    Cesk Fysiol 55:138-47. 2006
    ....
  45. ncbi Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor
    Hideki Kato
    Center for Tsukuba Advanced Research Alliance TARA, University of Tsukuba, Tsukuba, Ibaraki, Japan
    FASEB J 19:2023-5. 2005
    ..These results provide clear genetic evidence that activated RAS enhances erythropoiesis through the AT1a receptor of kidney cells and that this effect is mediated by the elevation of plasma erythropoietin levels in vivo...
  46. ncbi Intrarenal Renin-Angiotensin system is upregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesis
    Miguel Luis Graciano
    Renal Pathophysiology Laboratory, Nephrology Division, University of Sao Paulo, Brazil
    J Am Soc Nephrol 15:1805-15. 2004
    ..This study demonstrates the upregulation of local RAS in the kidney in a model of chronic progressive nephropathy...
  47. ncbi Renin-angiotensin vaccine: old story, new project 'efficacy versus safety'
    Jean Baptiste Michel
    INSERM Unit 460, CHU Xavier Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
    Clin Sci (Lond) 107:145-7. 2004
    ..Moreover, Ang I-immunized animals continued to respond to the pharmacological inhibition of renin-angiotensin system. These data provide evidence of the inability of antibodies to target Ang I within tissues...
  48. ncbi Interactions between subtotal nephrectomy and salt: effects on blood pressure and renal function in pregnant and nonpregnant ewes
    Karen J Gibson
    Department of Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
    Am J Physiol Regul Integr Comp Physiol 294:R1227-33. 2008
    ..As well, the increased production of vasorelaxants in pregnancy may selectively protect against the occurrence of salt-sensitive hypertension in pregnancy...
  49. ncbi Pleiotropic effects of angiotensin II receptor blocker in hypertensive patients
    Kwang Kon Koh
    Department of Cardiology, Vascular Medicine and Atherosclerosis Unit, Gil Heart Center, Gachon Medical School, 1198 Kuwol dong, Namdong gu, Incheon, Korea 405 760
    J Am Coll Cardiol 42:905-10. 2003
    ..We investigated the vascular effects of candesartan in hypertensive patients...
  50. ncbi Heart rate variability in white-coat hypertension
    Line B Madsen
    Department of Medical Research, Holstebro Hospital and Aarhus University, Aarhus, Denmark
    Blood Press Monit 13:65-71. 2008
    ....
  51. ncbi Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertension 47:894-900. 2006
    ....
  52. ncbi Tissue gene expression of renin-angiotensin system in human type 2 diabetic nephropathy
    Tadashi Konoshita
    Third Department of Internal Medicine, Fukui University School of Medicine, Matsuoka, Fukui 910 1193, Japan
    Diabetes Care 29:848-52. 2006
    ..The purpose of this study is to determine whether expression levels of RAS differ between nondiabetic and diabetic renal tissues with accurate quantitative method...
  53. ncbi Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats
    Raphael R de A Freitas
    Department of Physiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Am J Hypertens 20:692-8. 2007
    ..In addition, angiotensin I, II, and 1-7 levels were determined in plasma, heart, kidney, and the epididymal adipose tissue...
  54. ncbi Angiotensin as a target for the treatment of Alzheimer's disease, anxiety and depression
    Paul R Gard
    University of Brighton, School of Pharmacy and Biomolecular Sciences, UK
    Expert Opin Ther Targets 8:7-14. 2004
    ..Such effects, if proven, could promote the use of such agents in the treatment of hypertension coexisting with depression or anxiety...
  55. ncbi Genetic predisposition to neurological symptoms in lacunar infarction
    Jun Hui Zhang
    Department of Geriatric Medicine, Ehime University School of Medicine, Ehime, Japan
    Cerebrovasc Dis 17:273-9. 2004
    ..Lacunar infarction is a unique stroke entity with characteristic symptoms. However, it is often silent clinically. The possible genetic predisposition to symptoms of lacunar infarction was investigated...
  56. ncbi Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjects
    Morris J Brown
    Clinical Pharmacology Unit, Addenbrooke s Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Clin Sci (Lond) 107:167-73. 2004
    ..Biochemical measurements show evidence of blockade of the renin system, but higher titres will be required to achieve a decrease in blood pressure...
  57. pmc Increased hypothalamic angiotensin-(1-7) levels in rats with aortic coarctation-induced hypertension
    Mariela M Gironacci
    Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Peptides 28:1580-5. 2007
    ..The increased central levels of Ang-(1-7) in the CH rats suggest a potential mitigating role of this peptide in central control of the hypertensive process...
  58. ncbi Early streptozotocin-diabetes mellitus downregulates rat kidney AT2 receptors
    G J Wehbi
    Department of Cellular and Molecular Medicine, Division of Nephrology, The Kidney Research Centre, Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Ontario, Canada
    Am J Physiol Renal Physiol 280:F254-65. 2001
    ..Our data suggest that alterations in the balance of kidney AT1 and AT2 receptor expression may contribute to ANG II-mediated glomerular injury in progressive diabetic nephropathy...
  59. ncbi Spotlight on renin: intrarenal renin-angiotensin system--important player of the local milieu
    Hermann Haller
    Department of Nephrology, Hannover Medical School, Germany
    J Renin Angiotensin Aldosterone Syst 7:122-5. 2006
  60. ncbi Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes
    Kenichi Matsushita
    Department of Medicine, Duke University Medical Center, Durham NC 27710, USA
    Hypertension 48:1095-102. 2006
    ..Elucidation of the molecular mechanism should provide important insight into the pathophysiology of the metabolic syndrome and the development of future therapeutics...
  61. ncbi [Effector peptides of the brain renin-angiotensin system in central mechanisms of learned and natural forms of drinking behavior in rats]
    R Ia Vlasenko
    Zh Vyssh Nerv Deiat Im I P Pavlova 56:102-10. 2006
    ..b>Angiotensins modulated specific forms of thirst-associated behavior such as exploring, grooming, and ingestive behavior...
  62. ncbi [Recent trends in studies of the etiology of hypertension: Renal mechanism of blood pressure regulation]
    S Ito
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Tohoku University School of Medicine
    Nippon Rinsho 59:872-7. 2001
    ....
  63. ncbi Renin-angiotensin-system blockade in the prevention of diabetes
    Jan Ostergren
    Department of Medicine, Karolinska University Hospital, Solna, 17176 Stockholm, Sweden
    Diabetes Res Clin Pract 76:S13-21. 2007
    ..Nevertheless, a treatment that can control hypertension and reduce the risk of onset of type 2 diabetes at the same time is certainly desirable...
  64. ncbi Mechanism of the cardioprotective effect of inhibition of the renin-angiotensin system on ischemia/reperfusion-induced myocardial injury
    L X Wang
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Hypertens Res 24:179-87. 2001
    ..837, p<0.001). These results suggest that both the accumulation of bradykinin and inhibition of AT2 receptor are cardioprotective against IR injury through the activation of ERK, but not JNK...
  65. ncbi Incretory renal functions--Tigerstedt, renin and its neglected antagonist medullipin
    B Folkow
    Department of Physiology, Institute of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
    Acta Physiol (Oxf) 190:99-102. 2007
  66. ncbi Corpuscles of Stannius secrete renin or an isorenin that regulates cardiovascular function in freshwater North American eels, Anguilla rostrata LeSueur
    D G Butler
    Department of Zoology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
    Gen Comp Endocrinol 124:199-217. 2001
    ..These findings support strongly the hypothesis that the corpuscles of Stannius secrete renin or isorenin and that the renin-angiotensin system regulates cardiovascular function in freshwater eels and other bony fishes that possess them...
  67. ncbi Circulating renin Angiotensin system in childhood chronic renal failure: marked increase of Angiotensin-(1-7) in end-stage renal disease
    Ana C Simoes e Silva
    Department of Pediatrics, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30130 100, Brazil
    Pediatr Res 60:734-9. 2006
    ..Our data showed different circulating RAS profiles between hypertensive and in normotensive CRF subjects. Marked changes in plasma Ang-(1-7) were associated with the presence of hypertension and progression of kidney dysfunction...
  68. ncbi Tissue renin angiotensin systems
    Richard N Re
    Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Med Clin North Am 88:19-38. 2004
    ..It is to be expected that with enhanced understanding of the biology of the multiple RASs, new suggestions for therapeutic interventions will be forthcoming...
  69. ncbi The benefits of renin-angiotensin blockade in hypertension are dependent on blood-pressure lowering
    Anil K Bidani
    Division of Nephrology and Hypertension at Loyola University Medical Center, Maywood, IL 60153, USA
    Nat Clin Pract Nephrol 2:542-3. 2006
  70. ncbi Differential sympathetic and angiotensinergic responses in rats submitted to low- or high-salt diet
    B A Carillo
    Department of Physiology, Federal University of Sao Paulo, School of Medicine, Sao Paulo, SP, Brazil
    Regul Pept 140:5-11. 2007
    ..These changes are probably in favor of the antinatriuretic response and the sodium homeostasis in the low-salt group...
  71. ncbi The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathology
    Genevieve Nguyen
    Institut National de la Sante et de la Recherche Medicale, College de France, Experimental Medicine Unit, Paris, France
    Curr Opin Nephrol Hypertens 16:129-33. 2007
    ..The present review summarizes the findings, suggesting that it may play pathological role in cardiac and renal fibrosis, and in hypertensive and diabetic nephropathy...
  72. ncbi Dissociation of blood pressure and sympathetic activation of renin release in sinoaortic-denervated rats
    Marta H Krieger
    Department of Physiology and Biophysics, Institute of Biology, State University of Campinas, Campinas, SP, Brazil
    Clin Exp Pharmacol Physiol 33:471-6. 2006
    ..86 +/- 0.77 ng AngI/mL per h; n = 5; P < 0.05). Renin mRNA levels in the kidneys were unchanged in all groups. 6. These results show that an elevation in BP appears to offset increased renal sympathetic discharge with no change in PRA...
  73. ncbi Temporary treatment of prepubescent rats with angiotensin inhibitors suppresses the development of hypertensive nephrosclerosis
    H Nakaya
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
    J Am Soc Nephrol 12:659-66. 2001
    ....
  74. ncbi Renal thrombotic microangiopathy in a genetic model of hypertension in mice
    Sanjeev Sethi
    Department of Pathology, Mayo Clinic, 200 1st Street S W, Rochester, MN 55905, USA
    Exp Biol Med (Maywood) 231:196-203. 2006
    ..In summary, these studies characterize vascular and glomerular lesions in R+/A+ mice fed high salt, L-NAME, or both high salt and L-NAME, and provide a murine model of malignant hypertension with renal thrombotic microangiopathy...
  75. ncbi Low birth weight in response to salt restriction during pregnancy is not due to alterations in uterine-placental blood flow or the placental and peripheral renin-angiotensin system
    Sandra Márcia Leandro
    Department of Internal Medicine, Laboratory of Experimental Hypertension, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
    Physiol Behav 95:145-51. 2008
    ..and plasma and tissue angiotensin-converting enzyme (ACE) activity, as well as plasma and placental levels of angiotensins I, II, and 1-7 were measured. Body weight and kidney mass were greater in HS than in NS and LS dams...
  76. ncbi Effects of ANG II and III and angiotensin receptor blockers on nasal salt gland secretion and arterial blood pressure in conscious Pekin ducks (Anas platyrhynchos)
    D G Butler
    Department of Zoology, University of Toronto, Ontario, Canada
    J Comp Physiol B 168:213-24. 1998
    ..We studied the effects of some angiotensins and mammalian ANG II receptor antagonists on nasal salt gland function and arterial blood pressure in conscious ..
  77. ncbi [Renal tissue angiotensins during converting enzyme inhibition of angiotensin I in spontaneously hypertensive rat]
    C Ingert
    , , , Strasbourg
    Arch Mal Coeur Vaiss 90:1135-41. 1997
    ....
  78. ncbi [Immunologic approach of the blockage of the renin angiotensin system in vivo]
    J B Michel
    INSERM U 36, Paris
    Arch Mal Coeur Vaiss 81:281-90. 1988
    To block the renin-angiotensin system by antibodies directed against renin or angiotensins is an old and recent goal...
  79. ncbi TTF-1, a homeodomain-containing transcription factor, participates in the control of body fluid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical organ
    Young June Son
    Department of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan 680 749, South Korea
    J Biol Chem 278:27043-52. 2003
    In recent years, it has become increasingly evident that angiotensins synthesized in the brain contribute to regulating body fluid homeostasis...
  80. ncbi Neuropeptide conversion to bioactive fragments--an important pathway in neuromodulation
    M Hallberg
    Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
    Curr Protein Pept Sci 4:31-44. 2003
    ..Focus will be directed to the tachykinins, the opioid peptides, angiotensins as well as to CGRP, bradykinin and nociceptin...
  81. ncbi [Effect of a non-antihypertensive dose of ramipril on the plasma and tissue renin-angiotensin system in 27 TGR (mRen2) rats.]
    M Grima
    Institut de Pharmacologie, , , Strasbourg
    Arch Mal Coeur Vaiss 94:805-12. 2001
    ..On each tissue samples and plasma, angiotensinogen (Aogen), the renin activity, angiotensins I (Ang I) and II (Ang II) were determined by radioimmuno assay and the activity of ACE was measured by ..
  82. ncbi Angiotensin I-to-II conversion in the human renal vascular bed
    A H Danser
    Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
    J Hypertens 16:2051-6. 1998
    ..to result in detectable renal venous 125I-angiotensin II levels, especially in view of the extensive degradation of angiotensins in the kidney. To overcome this problem, we now infused 125I-angiotensin I directly into the renal artery.
  83. ncbi Angiotensin IV enhances LTP in rat dentate gyrus in vivo
    M J Wayner
    Division of Life Sciences, The University of Texas at San Antonio, 6900 N Loop 1604 W, San Antonio, TX 78249 0662, USA
    Peptides 22:1403-14. 2001
    b>Angiotensins have been shown to play a significant role in a variety of physiological functions including learning and memory processes...
  84. ncbi Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humans
    J E Jalil
    Department of Cardiovascular Diseases, Medical School, P Catholic University of Chile, Marcoleta, Chile
    J Hum Hypertens 18:119-25. 2004
    Neutral endopeptidase (NEP) hydrolyses angiotensins (Ang) I and II and generates angiotensin-(1-7) [Ang-(1-7)]...
  85. ncbi Angiotensin II in the evolution of experimental heart failure
    A Luchner
    Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
    Hypertension 28:472-7. 1996
    ..Ang II was measured by radioimmunoassay with low cross-reactivity to other angiotensins. Control, early left ventricular dysfunction, and overt congestive heart failure dogs were studied...
  86. ncbi Posterior hypothalamus cholinergic stimulation-induced activation of anterior hypothalamic area neurons is enhanced in spontaneously hypertensive rats
    Takao Kubo
    Department of Pharmacology, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
    Brain Res 1061:36-41. 2005
    ..demonstrated that some neurons in the anterior hypothalamic area (AHA) are tonically activated by endogenous angiotensins in rats and that activities of these AHA neurons are enhanced in spontaneously hypertensive rats (SHR)...
  87. ncbi Central pressor actions of aminopeptidase-resistant angiotensin II analogs: challenging the angiotensin III hypothesis
    Ranjita J Kokje
    Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Hypertension 49:1328-35. 2007
    Intracerebroventricular administration of angiotensins causes pronounced pressor and dipsogenic responses...
  88. pmc Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia
    Hans Imboden
    Institute of Cell Biology, University of Bern, Bern, Switzerland
    Regul Pept 154:23-31. 2009
    ..In some neurons Substance P was found colocalized with Ang II. Angiotensins from rat trigeminal ganglia were quantitated by radioimmunoassay with and without prior separation by high ..
  89. ncbi Angiotensin modulates long-term memory expression but not long-term memory storage in the crab Chasmagnathus
    Lia Frenkel
    Laboratorio de Neurobiologia de la Memoria, Departamento de Fisiologia y Biologia Molecular, IFIBYNE CONICET, Pabellon II, FCEyN, Universidad de Buenos Aires, Ciudad Universitaria C1428EHA, Argentina
    Neurobiol Learn Mem 94:509-20. 2010
    ..A parsimonious hypothesis is that in Chasmagnathus angiotensins regulate LTM expression, but not LTM storage. Here, we tested three predictions of this hypothesis...
  90. ncbi Roles of brain angiotensins II and III in thirst and sodium appetite
    Wendy L Wilson
    Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
    Brain Res 1060:108-17. 2005
    ..However, these results do not resolve the primary question of whether conversion of AngII to AngIII is a prerequisite to dipsogenic and salt appetite responses in the brain...
  91. ncbi Significance of vascular renin for local generation of angiotensins
    K Higashimori
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tenn 37232
    Hypertension 17:270-7. 1991
    ..angiotensin converting enzyme inhibitors, indomethacin, and prostaglandin I2 analogue on the release of angiotensins from isolated and Krebs-Ringer-perfused rabbit mesenteric arteries were examined...
  92. ncbi Activities of hypothalamic angiotensin II-sensitive neurons are greately enhanced even in prehypertensive spontaneously hypertensive rats
    Takao Kubo
    Department of Pharmacology, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
    Neurosci Lett 397:74-8. 2006
    ..that some neurons in the anterior hypothalamic area (AHA) of rats are tonically activated by endogenous angiotensins and that reactivities of these neurons to angiotensin II are enhanced in 15- to 16-week-old spontaneously ..
  93. ncbi Molecular interactions of vasoactive systems in cardiovascular damage
    M Bader
    Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
    J Cardiovasc Pharmacol 38:S7-9. 2001
    ..The two systems interact on many levels. Angiotensin-converting enzyme (ACE) activates angiotensins and inactivates kinins...
  94. ncbi Nonparallel effects of renin inhibitor treatment on plasma renin activity and angiotensins I and II in hypertensive subjects. An assay-related artifact
    F H Derkx
    Department of Internal Medicine I, University Hospital Dykzigt, Erasmus University, Rotterdam, The Netherlands
    Am J Hypertens 4:602-9. 1991
    Nonparallel effects of renin inhibitor treatment on plasma renin activity (PRA) and the plasma levels of angiotensins (ANG), as well as on blood pressure, have been observed in subjects with hypertension...
  95. ncbi Vasopressor and depressor effects of native angiotensins and inhibition of these effects in the Japanese quail
    Y Takei
    Department of Physiology, Kitasato University School of Medicine, Kanagawa, Japan
    Gen Comp Endocrinol 79:12-22. 1990
    ..These results indicate that vascular ANG II receptors and ANG I converting enzyme in the quail may be different from those in mammals...
  96. ncbi Effector peptides of the renin-angiotensin system in the central mechanisms of acquired and innate behavior in thirst in rats
    R Ya Vlasenko
    Department of Normal Physiology, Institute of Medical Education, Yaroslav Mudryi Novgorod State University, Velikii Novgorod
    Neurosci Behav Physiol 37:263-70. 2007
    ..central (intracerebroventricular) microinjection, [des-Asp1]-angiotensin I at doses equieffective to those of angiotensins II and III was found to be involved only in the performance of simple (taking water from the bowl) and linked ..
  97. ncbi Renin/prorenin receptors
    G Nguyen
    Institut National de la Sante et de la Recherche Medicale, INSERM Unit 36, College de France, Unit of Experimental Medicine, Paris, France
    Kidney Int 69:1503-6. 2006
    ..and the intracellular proteolysis of prorenin in mature renin did not provoke any generation of intracellular angiotensins. In contrast to the M6P-R, (pro)renin bound to the specific receptor was not degraded...
  98. ncbi Angiotensins differentially activate phospholipase D in vascular smooth muscle cells from spontaneously hypertensive and Wistar-Kyoto rats
    E J Freeman
    Calhoun Research Laboratory, Department of Internal Medicine, Akron Medical Center, OH 44307, USA
    Am J Hypertens 8:1105-11. 1995
    ..Moreover, activation of PLD by angiotensins in VMSC from the SHR is significantly more robust than that observed in VSMC from the normotensive WKY rat...
  99. ncbi Protein kinase C activation-induced increases of neural activity are enhanced in the hypothalamus of spontaneously hypertensive rats
    Takao Kubo
    Department of Pharmacology, Showa Pharmaceutical University, Higasi tamagawagakuen, Machida, Tokyo 194 8543, Japan
    Brain Res 1033:157-63. 2005
    ..reported that some neurons in the anterior hypothalamic area (AHA) are tonically activated by endogenous angiotensins in rats and that activities of these angiotensin II-sensitive neurons in the AHA are enhanced in spontaneously ..
  100. ncbi D2 dopamine receptor blockade prevents cognitive effects of Ang IV and des-Phe6 Ang IV
    J J Braszko
    Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15 A, PL 15274 Bialystok, Poland
    Physiol Behav 88:152-9. 2006
    b>Angiotensins, especially angiotensin IV (Ang IV), have recently been found to be potent cognitive enhancers in rodents. However, the precise mechanisms of their memory improving effects remain unknown...
  101. ncbi Differential regulation of renal angiotensin-converting enzyme (ACE) and ACE2 during ACE inhibition and dietary sodium restriction in healthy rats
    I Hamming
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Exp Physiol 93:631-8. 2008
    ..treated with vehicle or lisinopril with either a control or a low-sodium diet, and renal ACE2, ACE and plasma angiotensins were studied...

Research Grants62

  1. ANGIOTENSINS, PROSTAGLANDINS-ADRENERGIC INTERACTIONS
    Kafait U Malik; Fiscal Year: 2013
    ....
  2. Development of a radioligand for assay of angiotensin-converting enzyme-2(ACE-2)
    ROBERT CHARLES SPETH; Fiscal Year: 2013
    ..b>Angiotensins II and III (Ang II &Ang III) act at the AT1 Ang II receptor subtype to cause pressor, fibrotic, mitogenic, ..
  3. Brain specific non-AT1, non-AT2 angiotensin binding site
    ROBERT CHARLES SPETH; Fiscal Year: 2010
    ..of peptide fragments of angiotensin II some having their own receptors, it is now known that brain angiotensins have a multitude of functions extending well beyond regulation of the cardiovascular system...
  4. Vasoactive Peptides that Stimulate Smooth Muscles
    RANDAL A contact SKIDGEL; Fiscal Year: 2010
    ..The Aims stem from our initial investigations of enzymes that metabolize peptides such as bradykinin (BK), angiotensins and others...
  5. PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROME
    Julie Ingelfinger; Fiscal Year: 2004
    ..This application will focus on the unique role of the PTC tissue RAS, hypothesizing that local angiotensins amplify the effects of Stx in PTC, resulting in further injury...
  6. OCULAR FUNCTIONS & PEPTIDE HORMONE SYSTEMS
    James Ryan; Fiscal Year: 1991
    ..target enzymes is known or believed to degrade one or more of the enkephalins, endorphins, tachykinins, kinins, angiotensins and larger hormone, (e.g. insulin) systems...
  7. GASTROINTESTINAL KALLIKREIN AND RENIN SYSTEMS
    Patrick Ward; Fiscal Year: 1990
    In addition to angiotensins and kinins, peptides such as substance P, VIP, enkephalins, neurotensin, somatostatin, etc...
  8. BRAIN ENDOPEPTIDASES AND NEUROPEPTIDE METABOLISM
    Sherwin Wilk; Fiscal Year: 2001
    ..Its substrates can include angiotensins I and II, cholecystokinin-8, and neuropeptide K. The sole produce of the action of D-AP on ang II is and III...
  9. ANGIOTENSIN EFFECTS IN HYPOTHALAMUS AND ADRENAL MEDULLA
    Marc Schiavone; Fiscal Year: 1993
    ..Particular interest has focused on the neuronal effects of angiotensins, but interpretation of such experiments has proven difficult because of the relatively rapid metabolism and low ..
  10. ROLES OF THE PROXIMAL TUBULE RENIN ANGIOTENSIN SYSTEM
    Julie Ingelfinger; Fiscal Year: 2000
    ..It is hypothesized that Ang II and other angiotensins produced locally within PT influence salt and water reabsorption by modulating transporters via specific ..
  11. NOVEL INSTRUMENTAL ASSAY OF PEPTIDES AND CHARGED SPECIES
    Steven Graves; Fiscal Year: 2000
    ..In Phase I we will target two families of molecules, catecholamines and angiotensins, important in the evaluation of hypertension and apply this approach to achieve more specific or sensitive ..
  12. BRAIN ANGIOTENSIN RECEPTOR FUNCTION CONTROL AND ANATOMY
    Robert Speth; Fiscal Year: 1993
    ..g., dipsogenesis and blood pressure changes, to angiotensins directly administered into the rat brain...
  13. REGULATION OF CARDIAC HYPERTROPHY BY ANGIOTENSINS
    Kenneth Baker; Fiscal Year: 2002
    ..abstract_text> ..
  14. FUNCTION OF THE MAS ONCOGENE
    LESLIE BLAIR; Fiscal Year: 1992
    The mas oncogene has recently been shown to encode an angiotensin receptor which responds preferentially to angiotensins III and II over angiotensin I, and is found primarily in neural tissue...
  15. ANGIOTENSIN 1-7 IN THE SPONTANEOUSLY HYPERTENSIVE
    Carlos Ferrario; Fiscal Year: 2000
    ..Hemodynamic studies will be complemented with measurements of angiotensins in the blood, urine and tissues and correlate assays in urine of prostaglandins and cGMP...
  16. CELL BIOLOGY OF PULMONARY ENDOTHELIUM
    Una Ryan; Fiscal Year: 1993
    ..postulated to metabolize one or more of bradykinin, kallidin, substance P, enkephalins and higher homologs, and angiotensins I, II or III...
  17. ATHEROGENESIS AND THE BONE MARROW ANGIOTENSIN SYSTEM
    Carlos Ferrario; Fiscal Year: 2004
    ..The proposed research will uncover novel mechanisms of atherogenesis that may have significant impact in the development of new therapeutic modalities applicable to cardiovascular and blood vessel diseases. ..
  18. REGULATION OF RENAL HEMODYNAMICS
    LUIS NAVAR; Fiscal Year: 2006
    ..The results will provide an improved understanding of how these intrarenal paracrine factors interact to produce a coordinate regulation of renal microvascular hemodynamics. ..
  19. Prenatal and Perinatal Programming of Adult Hypertension
    VESA VEHASKARI; Fiscal Year: 2006
    ..The effect of short-term postnatal dietary and phamacological manipulations on the long-term blood pressure profile will be investigated. ..
  20. Cue dependency with intravenous nutrients and nicotine
    Neil Rowland; Fiscal Year: 2007
    ..These studies may help to develop ways in conditioned preferences can be manipulated to prevent or treat certain addictive disorders, including overeating. [unreadable] [unreadable] [unreadable]..
  21. Regulated gene and stem cell induced cardioprotection
    Michael Phillips; Fiscal Year: 2007
    ..We will engineer bone marrow-derived stem cells to express HO-1 via ex vivo rAAV infection and evaluate their capacity to survive in ischemic myocardium and to improve cardiac function. ..
  22. Impaired Sodium Regulation and BP in Obese Youth
    Gregory Harshfield; Fiscal Year: 2006
    ..Finally, measures of target organ change will include left ventricular mass, diastolic function, and glomerular hyperfiltration as estimated from creatinine clearance. ..
  23. Cardiovascular Effects of lyengar Yoga
    Raymond Townsend; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  24. Circumventricular Organs and Cardiovascular Regulation
    JOHN COLLISTER; Fiscal Year: 2007
    ..The results of these studies will greatly enhance our understanding of the central effects of Angll at two specific brain regions, and how these interactions play a role in the long-term control of arterial pressure. ..
  25. Training Program in Molecular Medicine
    KATHLEEN BROSNIHAN; Fiscal Year: 2008
    ..This training grant will allow continued growth and recruitment of the most competitive applicants and minorities into the Program. [unreadable] [unreadable]..
  26. Dissecting complex traits with diverse resources
    Charles Kooperberg; Fiscal Year: 2008
    ..Particularly we focus on the methods that can be easily adapted for high-dimensional SNP data by exploiting the computational techniques developed in the first aim. [unreadable] [unreadable] [unreadable] [unreadable]..
  27. Physiology and genetics of food procurement in rodents
    Neil Rowland; Fiscal Year: 2008
    ..The proposed studies will be the first to address the issue of behavioral change induced by anorectics under such conditions of simulated economic costs. [unreadable] [unreadable] [unreadable]..
  28. Renal Function Derangements in Hypertension
    LUIS GABRIEL NAVAR; Fiscal Year: 2010
    ..The results obtained will further enhance our understanding of the important role of the intrarenal/intratubular/ interstitial renin angiotensin system in the pathophysiology of Ang II dependent hypertension. ..
  29. TGF-beta superfamily in neonatal obstructive nephropathy and recovery
    Robert L Chevalier; Fiscal Year: 2010
    ..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
  30. Androgens raise venous and arterial adrenergic tone.
    Douglas S Martin; Fiscal Year: 2010
    ..A better understanding the factors that control arterial and venous tone in hypertension may lead to design antihypertensive drugs with fewer adverse effects ..
  31. Intrarenal Augmentation of Angiotensinogen by Ang II
    Hiroyuki Kobori; Fiscal Year: 2010
    ..abstract_text> ..
  32. Prostaglandins: Kinins and Angiotensin Interactions
    JOHN MC GIFF; Fiscal Year: 2009
    ..3) Heme oxygenase activity and suppression of EET and 20-HETE synthesis. 4) Activation of peroxisome-proliferator-activated receptor alpha by Fibrates with stimulation of EET synthesis. ..
  33. Mathematical Model of Vascular and Tubular Transport in the Rat Outer Medulla
    AURELIE EDWARDS; Fiscal Year: 2008
    ..We will simulate the effects of renal perfusion pressure-induced elevations in medullary CO concentrations on mTAL sodium reabsorption, so as to gain some insight into the mechanisms underlying pressure natriuresis. ..
  34. Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)
    Patricia Gallagher; Fiscal Year: 2009
    ..The regulation of ACE2 may be critical to maintaining the normal function of the renin-angiotensin system in the brain. ..
  35. Effects of intracellular angiotensin II
    Julia Cook; Fiscal Year: 2009
    ..abstract_text> ..
  36. Adaptive Function Estimation for Genomic Data
    Charles Kooperberg; Fiscal Year: 2006
    ..In addition, we plan to develop methods to improve inference for polynomial spline methodologies. ..
  37. BRADYKININ IN CARDIOVASCULAR DISEASE
    Haralambos Gavras; Fiscal Year: 2006
    ..Understanding the contribution of each bradykinin receptor to vascular responses may help devise means to enhance their tissue-protective properties. ..
  38. MICROARRAY EXPRESSION PROFILING OF RODENT MODELS OF HUMA
    Haralambos Gavras; Fiscal Year: 2003
    ..abstract_text> ..
  39. Role of Ang-(1-7) in normal and hypertensive pregnancy
    K Brosnihan; Fiscal Year: 2003
    ..The major goal of these studies is to understand the contribution of the vasodilator component of the RAAS to blood pressure regulation in normal pregnancy. ..
  40. GENETIC ANALYSIS OF CARDIAC TERMINAL DIFFERENTIATION
    W MacLellan; Fiscal Year: 2003
    ..This first RO1 proposes to further define the role of PRI-1 in cardiac myocyte differentiation and elucidate its biochemical properties. ..
  41. DIETARY SALT INTAKE AND THE METABOLIC EFFECTS OF INSULIN
    Raymond Townsend; Fiscal Year: 2003
    ..If increased salt intake improves insulin sensitivity this should prompt a re-evaluation of the benefits of recommending a lower sodium intake in normotensive people. ..
  42. WEIGHT CONTROL FOR BLACK WOMEN'S CARDIOVASCULAR HEALTH
    Shiriki Kumanyika; Fiscal Year: 2002
    ..Two chapters will be randomized to each arm and will each recruit and follow 25 women. Individual adherence and chapter-level implementation variables will be assessed. ..
  43. ANGII NEURAL INTERACTIONS IN CARDIOVASCULAR CONTROL
    JOHN COLLISTER; Fiscal Year: 2002
    ..Upon completion, Dr. Collister will have fully developed into an independent investigator. ..
  44. NATRIURETIC PEPTIDE INHIBITS VEGF SYNTHESIS AND ACTIONS
    ELLIS LEVIN; Fiscal Year: 2002
    ..These will be shown by protein synthesis and kinase activity studies, in cells transfected with dominant negative SEK-1 (JNK kinase) and JNK-1, or PD98059 (Mek inhibitor). ..
  45. CELL GROWTH, NA/H EXCHANGE, AND CYCLINS IN IDDM PATIEN
    Daniel Batlle; Fiscal Year: 2002
    ....
  46. BEHAVIORAL STRESS AND SODIUM REGULATION IN YOUTHS
    Gregory Harshfield; Fiscal Year: 2001
    ..It will also define the hemodynamic response pattern associated with these changes. Finally, this study will examine these questions in a younger cohort than has been studied previously, providing new information on this population. ..
  47. Hypertension and alpha 2 adrenergic receptors
    Haralambos Gavras; Fiscal Year: 2004
    ....
  48. EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION
    Robert Shade; Fiscal Year: 2003
    ..Thus, the design of the proposed laboratory facility will provide efficient space currently needed by these programs while also improving the collaborative research environment for faculty and staff. ..
  49. C PROTEIN AND CROSS BRIDGE FUNCTION IN HEART MUSCLE
    Saul Winegrad; Fiscal Year: 2004
    ..Abnormalities in its structure and function are responsible for one of the more common forms of Familial Hypertrophic Cardiomyopathy. ..
  50. Weight Management Skills--African American Outpatients
    Shiriki Kumanyika; Fiscal Year: 2005
    ..Group 0. Secondary analyses will compare the respective treatment and control groups on diet, physical activity, and clinical CVD risk factor changes and will assess predictors of outcomes and cost-effectiveness. ..
  51. Equipment Support for USD Laboratory Animal Services
    Douglas Martin; Fiscal Year: 2005
    ..The long-term goal is to achieve AAALAC accreditation. It is expected that AAALAC review for accreditation will be requested within 18 months of completion and occupancy of the new LAS. ..
  52. Intercellular Signaling in Obstructive Nephropathy
    ROBERT CHEVALIER; Fiscal Year: 2005
    ..This will lead to improved outcomes in adulthood. ..
  53. Angiotensin, Sodium and Genes in Primate Hypertension
    Robert Shade; Fiscal Year: 2005
    ..Importantly, this work will also reveal whether the genetically determined phenotype of high SLC is important in predisposing an animal to sodium-dependent hypertension. ..
  54. Role of MMPs in AngII induced abdominal aortic aneurysms
    Alan Daugherty; Fiscal Year: 2005
    ..The significance of this research relates to delineation of mechanism for AA formation and maturation, with emphasis on potential development of pharmacological treatments of the disease. ..
  55. ANGIOTENSIN AND CENTRAL NEUROHUMORAL ACTIVATION IN CHF
    Robert Felder; Fiscal Year: 2005
    ..This work will provide new information concerning the role of the central nervous system in the pathophysiology of CHF and will draw attention to the possibility of CNS directed drug therapy for heart failure. ..
  56. Racial Differences--Stress Induced Homeostatic Response
    Gregory Harshfield; Fiscal Year: 2005
    ..abstract_text> ..
  57. Enhancing Subject Protections through Education
    Michael Phillips; Fiscal Year: 2003
    ..Using state-of-the-art technology, USF will share its educational programs with UCF, UCH, and community-based institutions conducting human subject research within the Tampa Bay area. ..
  58. UNIVERSITY OF SOUTH FLORIDA MOUSE BARRIER FACILITY
    M Phillips; Fiscal Year: 2004
    ..6 to 1. The net benefit of the movable equipment requested would accrue to nationally recognized life science research directed by scientists from eight neighboring institutions that will use this new regional resource. ..
  59. MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
    George Kaysen; Fiscal Year: 2001
    ..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..