Genomes and Genes
Summary: Oligopeptides ranging in size from angiotensin precursors with 14 amino acids to the active vasoconstrictor angiotensin II with 8 amino acids, or their analogs or derivatives. The amino acid content varies with the species and changes in that content produce antagonistic or inactive compounds.
Publications229 found, 100 shown here
- Angiotensin system inhibitors and outcome of sunitinib treatment in patients with metastatic renal cell carcinoma: a retrospective examinationDaniel Keizman
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
Eur J Cancer 47:1955-61. 2011..Data suggests that they may inhibit tumourigenesis...
- A new look at the renin-angiotensin system--focusing on the vascular systemAurelie Nguyen Dinh Cat
Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
Peptides 32:2141-50. 2011..The present review highlights recent progress in the RAS field, focusing on the tissue system and particularly on the vascular RAS...
- Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heartPaul J Garabelli
The Hypertension and Vascular Disease Center, Winston Salem, NC, USA
Exp Physiol 93:613-21. 2008..We determined the metabolism of angiotensins in wild-type (WT), ACE (ACE(-/-)) and ACE2 null mice (ACE2(-/-))...
- Effect of extracellular and intracellular angiotensins on heart cell function; on the cardiac renin-angiotensin systemWalmor De Mello
Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, PO Box 365067, San Juan, PR 00936 5067, USA
Regul Pept 114:87-90. 2003In this manuscript, I presented up-to-date evidence that intracellular and extracellular angiotensins have an important regulatory effect on the processes of heart cell communication and inward calcium current and that aldosterone ..
- Blockade of pro-cognitive effects of angiotensin IV and physostigmine in mice by oxytocin antagonismPaul R Gard
School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton, BN2 4GJ, UK
Eur J Pharmacol 683:155-60. 2012....
- Adrenal, kidney, and heart angiotensins in female murine Ren-2 transfected hypertensive ratsP S Senanayake
Eye Institute, The Cleveland Clinic Foundation, OH 44195, USA
Peptides 19:1685-94. 1998..In SD and transgenic rats kidney and adrenal angiotensins increased primarily during estrus or proestrus...
- Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptorsM M van den Eijnden
Cardiovascular Research Institute COEUR, Department of Pharmacology, Erasmus University Rotterdam, Rotterdam, The Netherlands
Arterioscler Thromb Vasc Biol 21:911-6. 2001..Most likely, therefore, in the absence of angiotensinogen synthesis or endocytosis, M6P receptor-mediated prorenin internalization by endothelial cells represents prorenin clearance...
- Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis ratsKarl D Pendergrass
Hypertension and Vascular Disease Ctr, Wake Forest Univ Health Sciences, Winston Salem, NC 27157 1095, USA
Am J Physiol Heart Circ Physiol 295:H10-20. 2008..The enhanced activity of the RAAS in male congenics may contribute to the higher pressure and tissue injury evident in the strain...
- Modulation of reflex function by endogenous angiotensins in older transgenic rats with low glial angiotensinogenAmy C Arnold
Hypertension and Vascular Research Center and Physiology and Pharmacology Department, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
Hypertension 51:1326-31. 2008..These results suggest a novel mechanism for the preservation of baroreflex sensitivity during aging...
- Evidence for the role of angiotensin II biosynthesis in the rat internal anal sphincter toneMarcio A F de Godoy
Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Gastroenterology 127:127-38. 2004..The internal anal sphincter tone is important for anorectal continence. This study examined the role of angiotensin II as a neurohumoral signal for the myogenic tone in the internal anal sphincter...
- Brain renin-angiotensin--a new look at an old systemJohn W Wright
Department of Psychology, Washington State University, P O Box 644820, Pullman, WA 99164 4820, USA
Prog Neurobiol 95:49-67. 2011..of an independent local brain RAS composed of the necessary functional components (angiotensinogen, peptidases, angiotensins and specific receptor proteins) significantly expanded the possible physiological and pharmacological functions ..
- Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomyCarlos M Ferrario
The Hypertension and Vascular Research Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157, USA
Am J Physiol Heart Circ Physiol 296:H1184-92. 2009..Nephrectomy yielded divergent effects on circulating and cardiac angiotensins. Significant decreases in plasma ANG-(1-12), ANG I, and ANG II levels postnephrectomy accompanied increases in ..
- Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heartAaron J Trask
Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Am J Physiol Heart Circ Physiol 294:H2242-7. 2008..This finding further suggests that this angiotensinogen-derived product is a previously unrecognized important precursor peptide to the renin-angiotensin system cascade...
- Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin IIHossam A Shaltout
Department of Obstetrics and Gynecology, Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1095, USA
Am J Physiol Renal Physiol 292:F82-91. 2007..Therefore, we investigated the metabolism of the angiotensins in isolated proximal tubules, urine, and serum from sheep...
- Body mass index and angiotensin-dependent control of the renal circulation in healthy humansSofia B Ahmed
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Hypertension 46:1316-20. 2005..Weight loss should be considered in the overweight or obese patient for renal protection...
- New angiotensinsJasmina Varagic
The Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Mol Med (Berl) 86:663-71. 2008..This review focuses on angiotensin-(1-7) and its important contribution to cardiovascular function and growth, while introducing angiotensin-(1-12) as a potential novel angiotensin precursor...
- Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptorWendy W Batenburg
Erasmus MC, Rotterdam, The Netherlands
J Hypertens 25:2441-53. 2007..Here, we evaluated the kinetics of renin/prorenin binding to the recently discovered human (pro)renin receptor (h(P)RR), and the idea that such binding underlies tissue angiotensin generation...
- Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosisAdam Kretowski
Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Mail Stop A140, P O Box 6511, Aurora, CO 80045 6511, USA
Diabetes 56:863-71. 2007....
- The effect of angiotensin 1-7 on tyrosine kinases activity in rat anterior pituitaryElzbieta Rebas
Department of Molecular Neurochemistry, Medical University of Lodz, Poland
Biochem Biophys Res Commun 347:581-5. 2006..The presence of PD123319 together with Ang 1-7 caused stronger inhibition PTKs activity than Ang 1-7 alone. These observations suggest that Ang 1-7 binds to the novel, unknown, specific for this peptide receptor...
- The involvement of angiotensins in the control of prostatic epithelial cell proliferation in the ratM Pawlikowski
Department of Experimental Endocrinology and Hormone Diagnostics, Institute of Endocrinology, , Poland
Folia Histochem Cytobiol 39:341-3. 2001The effects of captopril (the inhibitor of the angiotensin-converting enzyme) and of angiotensins II and IV (3-8 fragment of angiotensin II) on cell proliferation of the prostatic epithelium was investigated in the rat...
- Renin, angiotensins, and angiotensin-converting enzyme in neuroblastoma cells: evidence for intracellular formation of angiotensinsT Okamura
Proc Natl Acad Sci U S A 78:6940-3. 1981..19), angiotensin-converting enzyme (dipeptidyl carboxypeptidase; peptidyldipeptide hydrolase, EC 188.8.131.52), and angiotensins I and II...
- Overexpression of the local bone marrow renin-angiotensin system in acute myeloid leukemiaYavuz Beyazit
Department of Internal Medicine, Hacettepe University Medical School, Ankara, Turkey
J Natl Med Assoc 99:57-63. 2007..The aim of this study is therefore to search those major RAS components simultaneously in the leukemic blast cells taken from the bone marrow of patients with acute myeloid leukemia (AML)...
- Angiotensins in Alzheimer's disease - friend or foe?Patrick G Kehoe
Dementia Research Group, Institute of Clinical Neurosciences, Department of Clinical Science at North Bristol, University of Bristol, Frenchay Hospital, Bristol BS16 1LE, UK
Trends Neurosci 32:619-28. 2009..This paper reviews molecular, genetic, experimental and clinical data as well as the therapeutic opportunities that relate to the involvement of the RAS in AD...
- Urinary vasodilator and vasoconstrictor angiotensins during menstrual cycle, pregnancy, and lactationG Valdes
Departamento de Nefrologia, Centro de Investigaciones Medicas, Pontificia Universidad Catolica, Santiago, Chile
Endocrine 16:117-22. 2001..49,p < 0.001). The progressive rise of Ang-(1-7) throughout gestation, probably modulated by estrogen and progesterone, suggests a physiologic counterregulation within the RAAS...
- Intrauterine growth restriction in rats is associated with hypertension and renal dysfunction in adulthoodMarie Claude Battista
Research Center, Hôpital Sainte Justine and Department of Obstetrics and Gynecology, Universite de Montreal, Montreal, Quebec, Canada H3T 1C5
Am J Physiol Endocrinol Metab 283:E124-31. 2002..Differences observed between male and female adults suggest the importance of gender in outcomes in adulthood after IUGR...
- Historical perspective of the renin-angiotensin systemJohn E Hall
Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
Mol Biotechnol 24:27-39. 2003....
- The renin-angiotensin and the kallikrein-kinin systemsDuncan J Campbell
St Vincent s Institute of Medical Research, Fitzroy, VIC 3065, Australia
Int J Biochem Cell Biol 35:784-91. 2003..Both angiotensin and kinin peptides are metabolised by many different peptidases that are important determinants of the activities of the RAS and KKS, and several of which participate in both systems...
- Tissue renin-angiotensin system and end-organ damageFriedrich C Luft
Franz Volhard Klinik, Humboldt University of Berlin, Wiltbergstrasse 50, 13125 Berlin Buch, Germany
J Mol Med (Berl) 80:325-6. 2002
- Effect of dietary sodium intake on central angiotensinergic pathwaysGerald F DiBona
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
Auton Neurosci 98:17-9. 2002..These observations support the view that physiologically regulated angiotensin peptides of the brain origin exert a local paracrine or autocrine action on sites that influence the renal sympathetic nerve activity...
- Mechanism of increased angiotensin II levels in glomerular mesangial cells cultured in high glucoseRekha Singh
Department of Medicine, Veterans Affairs Hospital, Hines, Illinois, and Loyola University Stritch School of Medicine, Maywood, Illinois 60141, USA
J Am Soc Nephrol 14:873-80. 2003..In addition, this study provides new information that Ang(1-9) is produced by mesangial cells, can be converted to AngII, and that this conversion is also stimulated under high-glucose conditions...
- Differentiation in the effects of the angiotensin II receptor blocker class on autonomic functionMurray Esler
Baker Medical Research Institute, Commercial Road, Prahran 3181, Melbourne, Australia
J Hypertens Suppl 20:S13-9. 2002..A reduction in noradrenaline spillover disproportionate to any possible fall in nerve firing would document the presence of presynaptic antagonism of noradrenaline release...
- Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 ratJennifer L Wilkinson-Berka
Department of Physiology, The University of Melbourne, Grattan Street, Parkville 3010, Victoria, Australia
Mol Cell Endocrinol 194:201-9. 2002..In conclusion, macrophages and epithelial cells are the source of active renin in the rat thymus. The thymic RAS may have actions systemically and may also influence local processes such as blood flow and cell growth...
- Renin-angiotensin gene polymorphism in children with uremia and essential hypertensionFerenc Papp
Department of Pediatrics, University of Szeged, Koranyi fasor 14 15, 6720 Szeged, Hungary
Pediatr Nephrol 18:150-4. 2003..Furthermore, there was a significant increase in MT genotype frequency of ANG M235T polymorphism in pediatric ESRD and JEHT. The role of AT1R gene polymorphism needs further investigation...
- Prorenin uptake in the heart: a prerequisite for local angiotensin generation?A H Jan Danser
Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
J Mol Cell Cardiol 34:1463-72. 2002..e., immediate binding of angiotensin II to its receptors with minimal loss into the extracellular space...
- Organisation and functional role of the brain angiotensin systemCatherine Llorens-Cortes
Institut National de la Sante et de la Recherche Medicale, Paris, France
J Renin Angiotensin Aldosterone Syst 3:S39-48. 2002
- Left ventricular isovolumic relaxation and renin-angiotensin system in the growth restricted fetusPavel B Tsyvian
Mother and Child Care Institute, Yekaterinburg, Russia
Eur J Obstet Gynecol Reprod Biol 140:33-7. 2008..To determine left ventricular isovolumic relaxation time (LV IRT) in normally developing and growth restricted fetuses (FGR) as an indicator of fetal cardiac afterload and neonatal systolic blood pressure...
- New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathyDaniel Batlle
Division of Nephrology and Hypertension, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Curr Opin Nephrol Hypertens 17:250-7. 2008....
- Diabetes and retinal vascular disorders: role of the renin-angiotensin systemJennifer L Wilkinson-Berka
Department of Physiology, The University of Melbourne, Grattan St, Parkville, Victoria, Australia
Expert Rev Mol Med 6:1-18. 2004..This review examines the role of the RAS in diabetic retinopathy and retinopathy of prematurity, and the potential of RAS blockade as a treatment strategy for these vision-threatening diseases...
- Angiotensin-converting enzyme C-terminal catalytic domain is the main site of angiotensin I cleavage in vivoSebastien Fuchs
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
Hypertension 51:267-74. 2008..Although mice lacking C-domain activity have normal physiology under laboratory conditions, they respond less well to the stress of dehydration...
- [Renin-angiotensin system: molecular biology]J Zidzik
Ustav lekárskej biológie, Lekárska fakulta UPJS, Kosice
Cesk Fysiol 53:142-51. 2004..RAS may take part in formation and progression of these diseases. In this work we focus on molecular biology of RAS and polymorphisms of RAS genes...
- Molecular evidence of tissue renin-angiotensin systems: a focus on the brainKoji Sakai
Department of Internal Medicine and Physiology, 3181B Medical Education and Biomedical Research Facility, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Curr Hypertens Rep 7:135-40. 2005..In this chapter, we review data demonstrating the existence and function of intrinsic tissue RAS, with a primary focus on the brain...
- [Renin-angiotensin system]Sadayoshi Ito
Nihon Jinzo Gakkai Shi . 2007
- Early renal denervation prevents development of hypertension in growth-restricted offspringNorma B Ojeda
Department of Physiology, University of Mississippi Medical Center, Jackson, Mississippi, USA
Clin Exp Pharmacol Physiol 34:1212-6. 2007....
- [The renin-angiotensin system]Zuzana Husková
Institut klinické a experimentální medicíny Pracoviste experimentální medicíny, Praha
Cesk Fysiol 55:138-47. 2006....
- Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptorHideki Kato
Center for Tsukuba Advanced Research Alliance TARA, University of Tsukuba, Tsukuba, Ibaraki, Japan
FASEB J 19:2023-5. 2005..These results provide clear genetic evidence that activated RAS enhances erythropoiesis through the AT1a receptor of kidney cells and that this effect is mediated by the elevation of plasma erythropoietin levels in vivo...
- Intrarenal Renin-Angiotensin system is upregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesisMiguel Luis Graciano
Renal Pathophysiology Laboratory, Nephrology Division, University of Sao Paulo, Brazil
J Am Soc Nephrol 15:1805-15. 2004..This study demonstrates the upregulation of local RAS in the kidney in a model of chronic progressive nephropathy...
- Renin-angiotensin vaccine: old story, new project 'efficacy versus safety'Jean Baptiste Michel
INSERM Unit 460, CHU Xavier Bichat, 46 rue Henri Huchard, 75877 Paris Cedex 18, France
Clin Sci (Lond) 107:145-7. 2004..Moreover, Ang I-immunized animals continued to respond to the pharmacological inhibition of renin-angiotensin system. These data provide evidence of the inability of antibodies to target Ang I within tissues...
- Interactions between subtotal nephrectomy and salt: effects on blood pressure and renal function in pregnant and nonpregnant ewesKaren J Gibson
Department of Physiology and Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia
Am J Physiol Regul Integr Comp Physiol 294:R1227-33. 2008..As well, the increased production of vasorelaxants in pregnancy may selectively protect against the occurrence of salt-sensitive hypertension in pregnancy...
- Pleiotropic effects of angiotensin II receptor blocker in hypertensive patientsKwang Kon Koh
Department of Cardiology, Vascular Medicine and Atherosclerosis Unit, Gil Heart Center, Gachon Medical School, 1198 Kuwol dong, Namdong gu, Incheon, Korea 405 760
J Am Coll Cardiol 42:905-10. 2003..We investigated the vascular effects of candesartan in hypertensive patients...
- Heart rate variability in white-coat hypertensionLine B Madsen
Department of Medical Research, Holstebro Hospital and Aarhus University, Aarhus, Denmark
Blood Press Monit 13:65-71. 2008....
- Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertensionAtsuhiro Ichihara
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Hypertension 47:894-900. 2006....
- Tissue gene expression of renin-angiotensin system in human type 2 diabetic nephropathyTadashi Konoshita
Third Department of Internal Medicine, Fukui University School of Medicine, Matsuoka, Fukui 910 1193, Japan
Diabetes Care 29:848-52. 2006..The purpose of this study is to determine whether expression levels of RAS differ between nondiabetic and diabetic renal tissues with accurate quantitative method...
- Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed ratsRaphael R de A Freitas
Department of Physiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Am J Hypertens 20:692-8. 2007..In addition, angiotensin I, II, and 1-7 levels were determined in plasma, heart, kidney, and the epididymal adipose tissue...
- Angiotensin as a target for the treatment of Alzheimer's disease, anxiety and depressionPaul R Gard
University of Brighton, School of Pharmacy and Biomolecular Sciences, UK
Expert Opin Ther Targets 8:7-14. 2004..Such effects, if proven, could promote the use of such agents in the treatment of hypertension coexisting with depression or anxiety...
- Genetic predisposition to neurological symptoms in lacunar infarctionJun Hui Zhang
Department of Geriatric Medicine, Ehime University School of Medicine, Ehime, Japan
Cerebrovasc Dis 17:273-9. 2004..Lacunar infarction is a unique stroke entity with characteristic symptoms. However, it is often silent clinically. The possible genetic predisposition to symptoms of lacunar infarction was investigated...
- Randomized double-blind placebo-controlled study of an angiotensin immunotherapeutic vaccine (PMD3117) in hypertensive subjectsMorris J Brown
Clinical Pharmacology Unit, Addenbrooke s Centre for Clinical Investigation, Box 110, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
Clin Sci (Lond) 107:167-73. 2004..Biochemical measurements show evidence of blockade of the renin system, but higher titres will be required to achieve a decrease in blood pressure...
- Increased hypothalamic angiotensin-(1-7) levels in rats with aortic coarctation-induced hypertensionMariela M Gironacci
Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
Peptides 28:1580-5. 2007..The increased central levels of Ang-(1-7) in the CH rats suggest a potential mitigating role of this peptide in central control of the hypertensive process...
- Early streptozotocin-diabetes mellitus downregulates rat kidney AT2 receptorsG J Wehbi
Department of Cellular and Molecular Medicine, Division of Nephrology, The Kidney Research Centre, Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Ontario, Canada
Am J Physiol Renal Physiol 280:F254-65. 2001..Our data suggest that alterations in the balance of kidney AT1 and AT2 receptor expression may contribute to ANG II-mediated glomerular injury in progressive diabetic nephropathy...
- Spotlight on renin: intrarenal renin-angiotensin system--important player of the local milieuHermann Haller
Department of Nephrology, Hannover Medical School, Germany
J Renin Angiotensin Aldosterone Syst 7:122-5. 2006
- Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytesKenichi Matsushita
Department of Medicine, Duke University Medical Center, Durham NC 27710, USA
Hypertension 48:1095-102. 2006..Elucidation of the molecular mechanism should provide important insight into the pathophysiology of the metabolic syndrome and the development of future therapeutics...
- [Effector peptides of the brain renin-angiotensin system in central mechanisms of learned and natural forms of drinking behavior in rats]R Ia Vlasenko
Zh Vyssh Nerv Deiat Im I P Pavlova 56:102-10. 2006..b>Angiotensins modulated specific forms of thirst-associated behavior such as exploring, grooming, and ingestive behavior...
- [Recent trends in studies of the etiology of hypertension: Renal mechanism of blood pressure regulation]S Ito
Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Tohoku University School of Medicine
Nippon Rinsho 59:872-7. 2001....
- Renin-angiotensin-system blockade in the prevention of diabetesJan Ostergren
Department of Medicine, Karolinska University Hospital, Solna, 17176 Stockholm, Sweden
Diabetes Res Clin Pract 76:S13-21. 2007..Nevertheless, a treatment that can control hypertension and reduce the risk of onset of type 2 diabetes at the same time is certainly desirable...
- Mechanism of the cardioprotective effect of inhibition of the renin-angiotensin system on ischemia/reperfusion-induced myocardial injuryL X Wang
Department of Internal Medicine, Fukuoka University School of Medicine, Japan
Hypertens Res 24:179-87. 2001..837, p<0.001). These results suggest that both the accumulation of bradykinin and inhibition of AT2 receptor are cardioprotective against IR injury through the activation of ERK, but not JNK...
- Incretory renal functions--Tigerstedt, renin and its neglected antagonist medullipinB Folkow
Department of Physiology, Institute of Neuroscience and Physiology, Goteborg University, Goteborg, Sweden
Acta Physiol (Oxf) 190:99-102. 2007
- Corpuscles of Stannius secrete renin or an isorenin that regulates cardiovascular function in freshwater North American eels, Anguilla rostrata LeSueurD G Butler
Department of Zoology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
Gen Comp Endocrinol 124:199-217. 2001..These findings support strongly the hypothesis that the corpuscles of Stannius secrete renin or isorenin and that the renin-angiotensin system regulates cardiovascular function in freshwater eels and other bony fishes that possess them...
- Circulating renin Angiotensin system in childhood chronic renal failure: marked increase of Angiotensin-(1-7) in end-stage renal diseaseAna C Simoes e Silva
Department of Pediatrics, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30130 100, Brazil
Pediatr Res 60:734-9. 2006..Our data showed different circulating RAS profiles between hypertensive and in normotensive CRF subjects. Marked changes in plasma Ang-(1-7) were associated with the presence of hypertension and progression of kidney dysfunction...
- Tissue renin angiotensin systemsRichard N Re
Research Division, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
Med Clin North Am 88:19-38. 2004..It is to be expected that with enhanced understanding of the biology of the multiple RASs, new suggestions for therapeutic interventions will be forthcoming...
- The benefits of renin-angiotensin blockade in hypertension are dependent on blood-pressure loweringAnil K Bidani
Division of Nephrology and Hypertension at Loyola University Medical Center, Maywood, IL 60153, USA
Nat Clin Pract Nephrol 2:542-3. 2006
- Differential sympathetic and angiotensinergic responses in rats submitted to low- or high-salt dietB A Carillo
Department of Physiology, Federal University of Sao Paulo, School of Medicine, Sao Paulo, SP, Brazil
Regul Pept 140:5-11. 2007..These changes are probably in favor of the antinatriuretic response and the sodium homeostasis in the low-salt group...
- The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathologyGenevieve Nguyen
Institut National de la Sante et de la Recherche Medicale, College de France, Experimental Medicine Unit, Paris, France
Curr Opin Nephrol Hypertens 16:129-33. 2007..The present review summarizes the findings, suggesting that it may play pathological role in cardiac and renal fibrosis, and in hypertensive and diabetic nephropathy...
- Dissociation of blood pressure and sympathetic activation of renin release in sinoaortic-denervated ratsMarta H Krieger
Department of Physiology and Biophysics, Institute of Biology, State University of Campinas, Campinas, SP, Brazil
Clin Exp Pharmacol Physiol 33:471-6. 2006..86 +/- 0.77 ng AngI/mL per h; n = 5; P < 0.05). Renin mRNA levels in the kidneys were unchanged in all groups. 6. These results show that an elevation in BP appears to offset increased renal sympathetic discharge with no change in PRA...
- Temporary treatment of prepubescent rats with angiotensin inhibitors suppresses the development of hypertensive nephrosclerosisH Nakaya
Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
J Am Soc Nephrol 12:659-66. 2001....
- Renal thrombotic microangiopathy in a genetic model of hypertension in miceSanjeev Sethi
Department of Pathology, Mayo Clinic, 200 1st Street S W, Rochester, MN 55905, USA
Exp Biol Med (Maywood) 231:196-203. 2006..In summary, these studies characterize vascular and glomerular lesions in R+/A+ mice fed high salt, L-NAME, or both high salt and L-NAME, and provide a murine model of malignant hypertension with renal thrombotic microangiopathy...
- Low birth weight in response to salt restriction during pregnancy is not due to alterations in uterine-placental blood flow or the placental and peripheral renin-angiotensin systemSandra Márcia Leandro
Department of Internal Medicine, Laboratory of Experimental Hypertension, University of Sao Paulo School of Medicine, Sao Paulo, Brazil
Physiol Behav 95:145-51. 2008..and plasma and tissue angiotensin-converting enzyme (ACE) activity, as well as plasma and placental levels of angiotensins I, II, and 1-7 were measured. Body weight and kidney mass were greater in HS than in NS and LS dams...
- Effects of ANG II and III and angiotensin receptor blockers on nasal salt gland secretion and arterial blood pressure in conscious Pekin ducks (Anas platyrhynchos)D G Butler
Department of Zoology, University of Toronto, Ontario, Canada
J Comp Physiol B 168:213-24. 1998..We studied the effects of some angiotensins and mammalian ANG II receptor antagonists on nasal salt gland function and arterial blood pressure in conscious ..
- [Renal tissue angiotensins during converting enzyme inhibition of angiotensin I in spontaneously hypertensive rat]C Ingert
, , , Strasbourg
Arch Mal Coeur Vaiss 90:1135-41. 1997....
- [Immunologic approach of the blockage of the renin angiotensin system in vivo]J B Michel
INSERM U 36, Paris
Arch Mal Coeur Vaiss 81:281-90. 1988To block the renin-angiotensin system by antibodies directed against renin or angiotensins is an old and recent goal...
- TTF-1, a homeodomain-containing transcription factor, participates in the control of body fluid homeostasis by regulating angiotensinogen gene transcription in the rat subfornical organYoung June Son
Department of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan 680 749, South Korea
J Biol Chem 278:27043-52. 2003In recent years, it has become increasingly evident that angiotensins synthesized in the brain contribute to regulating body fluid homeostasis...
- Neuropeptide conversion to bioactive fragments--an important pathway in neuromodulationM Hallberg
Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
Curr Protein Pept Sci 4:31-44. 2003..Focus will be directed to the tachykinins, the opioid peptides, angiotensins as well as to CGRP, bradykinin and nociceptin...
- [Effect of a non-antihypertensive dose of ramipril on the plasma and tissue renin-angiotensin system in 27 TGR (mRen2) rats.]M Grima
Institut de Pharmacologie, , , Strasbourg
Arch Mal Coeur Vaiss 94:805-12. 2001..On each tissue samples and plasma, angiotensinogen (Aogen), the renin activity, angiotensins I (Ang I) and II (Ang II) were determined by radioimmuno assay and the activity of ACE was measured by ..
- Angiotensin I-to-II conversion in the human renal vascular bedA H Danser
Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
J Hypertens 16:2051-6. 1998..to result in detectable renal venous 125I-angiotensin II levels, especially in view of the extensive degradation of angiotensins in the kidney. To overcome this problem, we now infused 125I-angiotensin I directly into the renal artery.
- Angiotensin IV enhances LTP in rat dentate gyrus in vivoM J Wayner
Division of Life Sciences, The University of Texas at San Antonio, 6900 N Loop 1604 W, San Antonio, TX 78249 0662, USA
Peptides 22:1403-14. 2001b>Angiotensins have been shown to play a significant role in a variety of physiological functions including learning and memory processes...
- Neutral endopeptidase and angiotensin I converting enzyme insertion/deletion gene polymorphism in humansJ E Jalil
Department of Cardiovascular Diseases, Medical School, P Catholic University of Chile, Marcoleta, Chile
J Hum Hypertens 18:119-25. 2004Neutral endopeptidase (NEP) hydrolyses angiotensins (Ang) I and II and generates angiotensin-(1-7) [Ang-(1-7)]...
- Angiotensin II in the evolution of experimental heart failureA Luchner
Cardiorenal Research Laboratory, Mayo Clinic and Foundation, Rochester, Minn 55905, USA
Hypertension 28:472-7. 1996..Ang II was measured by radioimmunoassay with low cross-reactivity to other angiotensins. Control, early left ventricular dysfunction, and overt congestive heart failure dogs were studied...
- Posterior hypothalamus cholinergic stimulation-induced activation of anterior hypothalamic area neurons is enhanced in spontaneously hypertensive ratsTakao Kubo
Department of Pharmacology, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
Brain Res 1061:36-41. 2005..demonstrated that some neurons in the anterior hypothalamic area (AHA) are tonically activated by endogenous angiotensins in rats and that activities of these AHA neurons are enhanced in spontaneously hypertensive rats (SHR)...
- Central pressor actions of aminopeptidase-resistant angiotensin II analogs: challenging the angiotensin III hypothesisRanjita J Kokje
Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Hypertension 49:1328-35. 2007Intracerebroventricular administration of angiotensins causes pronounced pressor and dipsogenic responses...
- Endogenous angiotensinergic system in neurons of rat and human trigeminal gangliaHans Imboden
Institute of Cell Biology, University of Bern, Bern, Switzerland
Regul Pept 154:23-31. 2009..In some neurons Substance P was found colocalized with Ang II. Angiotensins from rat trigeminal ganglia were quantitated by radioimmunoassay with and without prior separation by high ..
- Angiotensin modulates long-term memory expression but not long-term memory storage in the crab ChasmagnathusLia Frenkel
Laboratorio de Neurobiologia de la Memoria, Departamento de Fisiologia y Biologia Molecular, IFIBYNE CONICET, Pabellon II, FCEyN, Universidad de Buenos Aires, Ciudad Universitaria C1428EHA, Argentina
Neurobiol Learn Mem 94:509-20. 2010..A parsimonious hypothesis is that in Chasmagnathus angiotensins regulate LTM expression, but not LTM storage. Here, we tested three predictions of this hypothesis...
- Roles of brain angiotensins II and III in thirst and sodium appetiteWendy L Wilson
Department of Psychology, Washington State University, Pullman, WA 99164 4820, USA
Brain Res 1060:108-17. 2005..However, these results do not resolve the primary question of whether conversion of AngII to AngIII is a prerequisite to dipsogenic and salt appetite responses in the brain...
- Significance of vascular renin for local generation of angiotensinsK Higashimori
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tenn 37232
Hypertension 17:270-7. 1991..angiotensin converting enzyme inhibitors, indomethacin, and prostaglandin I2 analogue on the release of angiotensins from isolated and Krebs-Ringer-perfused rabbit mesenteric arteries were examined...
- Activities of hypothalamic angiotensin II-sensitive neurons are greately enhanced even in prehypertensive spontaneously hypertensive ratsTakao Kubo
Department of Pharmacology, Showa Pharmaceutical University, Machida, Tokyo 194 8543, Japan
Neurosci Lett 397:74-8. 2006..that some neurons in the anterior hypothalamic area (AHA) of rats are tonically activated by endogenous angiotensins and that reactivities of these neurons to angiotensin II are enhanced in 15- to 16-week-old spontaneously ..
- Molecular interactions of vasoactive systems in cardiovascular damageM Bader
Max Delbruck Center for Molecular Medicine, Berlin Buch, Germany
J Cardiovasc Pharmacol 38:S7-9. 2001..The two systems interact on many levels. Angiotensin-converting enzyme (ACE) activates angiotensins and inactivates kinins...
- Nonparallel effects of renin inhibitor treatment on plasma renin activity and angiotensins I and II in hypertensive subjects. An assay-related artifactF H Derkx
Department of Internal Medicine I, University Hospital Dykzigt, Erasmus University, Rotterdam, The Netherlands
Am J Hypertens 4:602-9. 1991Nonparallel effects of renin inhibitor treatment on plasma renin activity (PRA) and the plasma levels of angiotensins (ANG), as well as on blood pressure, have been observed in subjects with hypertension...
- Vasopressor and depressor effects of native angiotensins and inhibition of these effects in the Japanese quailY Takei
Department of Physiology, Kitasato University School of Medicine, Kanagawa, Japan
Gen Comp Endocrinol 79:12-22. 1990..These results indicate that vascular ANG II receptors and ANG I converting enzyme in the quail may be different from those in mammals...
- Effector peptides of the renin-angiotensin system in the central mechanisms of acquired and innate behavior in thirst in ratsR Ya Vlasenko
Department of Normal Physiology, Institute of Medical Education, Yaroslav Mudryi Novgorod State University, Velikii Novgorod
Neurosci Behav Physiol 37:263-70. 2007..central (intracerebroventricular) microinjection, [des-Asp1]-angiotensin I at doses equieffective to those of angiotensins II and III was found to be involved only in the performance of simple (taking water from the bowl) and linked ..
- Renin/prorenin receptorsG Nguyen
Institut National de la Sante et de la Recherche Medicale, INSERM Unit 36, College de France, Unit of Experimental Medicine, Paris, France
Kidney Int 69:1503-6. 2006..and the intracellular proteolysis of prorenin in mature renin did not provoke any generation of intracellular angiotensins. In contrast to the M6P-R, (pro)renin bound to the specific receptor was not degraded...
- Angiotensins differentially activate phospholipase D in vascular smooth muscle cells from spontaneously hypertensive and Wistar-Kyoto ratsE J Freeman
Calhoun Research Laboratory, Department of Internal Medicine, Akron Medical Center, OH 44307, USA
Am J Hypertens 8:1105-11. 1995..Moreover, activation of PLD by angiotensins in VMSC from the SHR is significantly more robust than that observed in VSMC from the normotensive WKY rat...
- Protein kinase C activation-induced increases of neural activity are enhanced in the hypothalamus of spontaneously hypertensive ratsTakao Kubo
Department of Pharmacology, Showa Pharmaceutical University, Higasi tamagawagakuen, Machida, Tokyo 194 8543, Japan
Brain Res 1033:157-63. 2005..reported that some neurons in the anterior hypothalamic area (AHA) are tonically activated by endogenous angiotensins in rats and that activities of these angiotensin II-sensitive neurons in the AHA are enhanced in spontaneously ..
- D2 dopamine receptor blockade prevents cognitive effects of Ang IV and des-Phe6 Ang IVJ J Braszko
Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15 A, PL 15274 Bialystok, Poland
Physiol Behav 88:152-9. 2006b>Angiotensins, especially angiotensin IV (Ang IV), have recently been found to be potent cognitive enhancers in rodents. However, the precise mechanisms of their memory improving effects remain unknown...
- Differential regulation of renal angiotensin-converting enzyme (ACE) and ACE2 during ACE inhibition and dietary sodium restriction in healthy ratsI Hamming
Department of Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
Exp Physiol 93:631-8. 2008..treated with vehicle or lisinopril with either a control or a low-sodium diet, and renal ACE2, ACE and plasma angiotensins were studied...
- ANGIOTENSINS, PROSTAGLANDINS-ADRENERGIC INTERACTIONSKafait U Malik; Fiscal Year: 2013....
- Development of a radioligand for assay of angiotensin-converting enzyme-2(ACE-2)ROBERT CHARLES SPETH; Fiscal Year: 2013..b>Angiotensins II and III (Ang II &Ang III) act at the AT1 Ang II receptor subtype to cause pressor, fibrotic, mitogenic, ..
- Brain specific non-AT1, non-AT2 angiotensin binding siteROBERT CHARLES SPETH; Fiscal Year: 2010..of peptide fragments of angiotensin II some having their own receptors, it is now known that brain angiotensins have a multitude of functions extending well beyond regulation of the cardiovascular system...
- Vasoactive Peptides that Stimulate Smooth MusclesRANDAL A contact SKIDGEL; Fiscal Year: 2010..The Aims stem from our initial investigations of enzymes that metabolize peptides such as bradykinin (BK), angiotensins and others...
- PROXIMAL TUBULE ANGIOTENSINS--HEMOLYTIC UREMIC SYNDROMEJulie Ingelfinger; Fiscal Year: 2004..This application will focus on the unique role of the PTC tissue RAS, hypothesizing that local angiotensins amplify the effects of Stx in PTC, resulting in further injury...
- OCULAR FUNCTIONS & PEPTIDE HORMONE SYSTEMSJames Ryan; Fiscal Year: 1991..target enzymes is known or believed to degrade one or more of the enkephalins, endorphins, tachykinins, kinins, angiotensins and larger hormone, (e.g. insulin) systems...
- GASTROINTESTINAL KALLIKREIN AND RENIN SYSTEMSPatrick Ward; Fiscal Year: 1990In addition to angiotensins and kinins, peptides such as substance P, VIP, enkephalins, neurotensin, somatostatin, etc...
- BRAIN ENDOPEPTIDASES AND NEUROPEPTIDE METABOLISMSherwin Wilk; Fiscal Year: 2001..Its substrates can include angiotensins I and II, cholecystokinin-8, and neuropeptide K. The sole produce of the action of D-AP on ang II is and III...
- ANGIOTENSIN EFFECTS IN HYPOTHALAMUS AND ADRENAL MEDULLAMarc Schiavone; Fiscal Year: 1993..Particular interest has focused on the neuronal effects of angiotensins, but interpretation of such experiments has proven difficult because of the relatively rapid metabolism and low ..
- ROLES OF THE PROXIMAL TUBULE RENIN ANGIOTENSIN SYSTEMJulie Ingelfinger; Fiscal Year: 2000..It is hypothesized that Ang II and other angiotensins produced locally within PT influence salt and water reabsorption by modulating transporters via specific ..
- NOVEL INSTRUMENTAL ASSAY OF PEPTIDES AND CHARGED SPECIESSteven Graves; Fiscal Year: 2000..In Phase I we will target two families of molecules, catecholamines and angiotensins, important in the evaluation of hypertension and apply this approach to achieve more specific or sensitive ..
- BRAIN ANGIOTENSIN RECEPTOR FUNCTION CONTROL AND ANATOMYRobert Speth; Fiscal Year: 1993..g., dipsogenesis and blood pressure changes, to angiotensins directly administered into the rat brain...
- REGULATION OF CARDIAC HYPERTROPHY BY ANGIOTENSINSKenneth Baker; Fiscal Year: 2002..abstract_text> ..
- FUNCTION OF THE MAS ONCOGENELESLIE BLAIR; Fiscal Year: 1992The mas oncogene has recently been shown to encode an angiotensin receptor which responds preferentially to angiotensins III and II over angiotensin I, and is found primarily in neural tissue...
- ANGIOTENSIN 1-7 IN THE SPONTANEOUSLY HYPERTENSIVECarlos Ferrario; Fiscal Year: 2000..Hemodynamic studies will be complemented with measurements of angiotensins in the blood, urine and tissues and correlate assays in urine of prostaglandins and cGMP...
- CELL BIOLOGY OF PULMONARY ENDOTHELIUMUna Ryan; Fiscal Year: 1993..postulated to metabolize one or more of bradykinin, kallidin, substance P, enkephalins and higher homologs, and angiotensins I, II or III...
- ATHEROGENESIS AND THE BONE MARROW ANGIOTENSIN SYSTEMCarlos Ferrario; Fiscal Year: 2004..The proposed research will uncover novel mechanisms of atherogenesis that may have significant impact in the development of new therapeutic modalities applicable to cardiovascular and blood vessel diseases. ..
- REGULATION OF RENAL HEMODYNAMICSLUIS NAVAR; Fiscal Year: 2006..The results will provide an improved understanding of how these intrarenal paracrine factors interact to produce a coordinate regulation of renal microvascular hemodynamics. ..
- Prenatal and Perinatal Programming of Adult HypertensionVESA VEHASKARI; Fiscal Year: 2006..The effect of short-term postnatal dietary and phamacological manipulations on the long-term blood pressure profile will be investigated. ..
- Cue dependency with intravenous nutrients and nicotineNeil Rowland; Fiscal Year: 2007..These studies may help to develop ways in conditioned preferences can be manipulated to prevent or treat certain addictive disorders, including overeating. [unreadable] [unreadable] [unreadable]..
- Regulated gene and stem cell induced cardioprotectionMichael Phillips; Fiscal Year: 2007..We will engineer bone marrow-derived stem cells to express HO-1 via ex vivo rAAV infection and evaluate their capacity to survive in ischemic myocardium and to improve cardiac function. ..
- Impaired Sodium Regulation and BP in Obese YouthGregory Harshfield; Fiscal Year: 2006..Finally, measures of target organ change will include left ventricular mass, diastolic function, and glomerular hyperfiltration as estimated from creatinine clearance. ..
- Cardiovascular Effects of lyengar YogaRaymond Townsend; Fiscal Year: 2006..unreadable] [unreadable]..
- Circumventricular Organs and Cardiovascular RegulationJOHN COLLISTER; Fiscal Year: 2007..The results of these studies will greatly enhance our understanding of the central effects of Angll at two specific brain regions, and how these interactions play a role in the long-term control of arterial pressure. ..
- Training Program in Molecular MedicineKATHLEEN BROSNIHAN; Fiscal Year: 2008..This training grant will allow continued growth and recruitment of the most competitive applicants and minorities into the Program. [unreadable] [unreadable]..
- Dissecting complex traits with diverse resourcesCharles Kooperberg; Fiscal Year: 2008..Particularly we focus on the methods that can be easily adapted for high-dimensional SNP data by exploiting the computational techniques developed in the first aim. [unreadable] [unreadable] [unreadable] [unreadable]..
- Physiology and genetics of food procurement in rodentsNeil Rowland; Fiscal Year: 2008..The proposed studies will be the first to address the issue of behavioral change induced by anorectics under such conditions of simulated economic costs. [unreadable] [unreadable] [unreadable]..
- Renal Function Derangements in HypertensionLUIS GABRIEL NAVAR; Fiscal Year: 2010..The results obtained will further enhance our understanding of the important role of the intrarenal/intratubular/ interstitial renin angiotensin system in the pathophysiology of Ang II dependent hypertension. ..
- TGF-beta superfamily in neonatal obstructive nephropathy and recoveryRobert L Chevalier; Fiscal Year: 2010..A new animal (mouse) model is proposed to study the major cellular mechanisms for injury to the newborn kidney, as well as to evaluate new therapies to enhance recovery. ..
- Androgens raise venous and arterial adrenergic tone.Douglas S Martin; Fiscal Year: 2010..A better understanding the factors that control arterial and venous tone in hypertension may lead to design antihypertensive drugs with fewer adverse effects ..
- Intrarenal Augmentation of Angiotensinogen by Ang IIHiroyuki Kobori; Fiscal Year: 2010..abstract_text> ..
- Prostaglandins: Kinins and Angiotensin InteractionsJOHN MC GIFF; Fiscal Year: 2009..3) Heme oxygenase activity and suppression of EET and 20-HETE synthesis. 4) Activation of peroxisome-proliferator-activated receptor alpha by Fibrates with stimulation of EET synthesis. ..
- Mathematical Model of Vascular and Tubular Transport in the Rat Outer MedullaAURELIE EDWARDS; Fiscal Year: 2008..We will simulate the effects of renal perfusion pressure-induced elevations in medullary CO concentrations on mTAL sodium reabsorption, so as to gain some insight into the mechanisms underlying pressure natriuresis. ..
- Cellular Regulation of Angiotensin Converting Enzyme 2 (ACE2)Patricia Gallagher; Fiscal Year: 2009..The regulation of ACE2 may be critical to maintaining the normal function of the renin-angiotensin system in the brain. ..
- Effects of intracellular angiotensin IIJulia Cook; Fiscal Year: 2009..abstract_text> ..
- Adaptive Function Estimation for Genomic DataCharles Kooperberg; Fiscal Year: 2006..In addition, we plan to develop methods to improve inference for polynomial spline methodologies. ..
- BRADYKININ IN CARDIOVASCULAR DISEASEHaralambos Gavras; Fiscal Year: 2006..Understanding the contribution of each bradykinin receptor to vascular responses may help devise means to enhance their tissue-protective properties. ..
- MICROARRAY EXPRESSION PROFILING OF RODENT MODELS OF HUMAHaralambos Gavras; Fiscal Year: 2003..abstract_text> ..
- Role of Ang-(1-7) in normal and hypertensive pregnancyK Brosnihan; Fiscal Year: 2003..The major goal of these studies is to understand the contribution of the vasodilator component of the RAAS to blood pressure regulation in normal pregnancy. ..
- GENETIC ANALYSIS OF CARDIAC TERMINAL DIFFERENTIATIONW MacLellan; Fiscal Year: 2003..This first RO1 proposes to further define the role of PRI-1 in cardiac myocyte differentiation and elucidate its biochemical properties. ..
- DIETARY SALT INTAKE AND THE METABOLIC EFFECTS OF INSULINRaymond Townsend; Fiscal Year: 2003..If increased salt intake improves insulin sensitivity this should prompt a re-evaluation of the benefits of recommending a lower sodium intake in normotensive people. ..
- WEIGHT CONTROL FOR BLACK WOMEN'S CARDIOVASCULAR HEALTHShiriki Kumanyika; Fiscal Year: 2002..Two chapters will be randomized to each arm and will each recruit and follow 25 women. Individual adherence and chapter-level implementation variables will be assessed. ..
- ANGII NEURAL INTERACTIONS IN CARDIOVASCULAR CONTROLJOHN COLLISTER; Fiscal Year: 2002..Upon completion, Dr. Collister will have fully developed into an independent investigator. ..
- NATRIURETIC PEPTIDE INHIBITS VEGF SYNTHESIS AND ACTIONSELLIS LEVIN; Fiscal Year: 2002..These will be shown by protein synthesis and kinase activity studies, in cells transfected with dominant negative SEK-1 (JNK kinase) and JNK-1, or PD98059 (Mek inhibitor). ..
- CELL GROWTH, NA/H EXCHANGE, AND CYCLINS IN IDDM PATIENDaniel Batlle; Fiscal Year: 2002....
- BEHAVIORAL STRESS AND SODIUM REGULATION IN YOUTHSGregory Harshfield; Fiscal Year: 2001..It will also define the hemodynamic response pattern associated with these changes. Finally, this study will examine these questions in a younger cohort than has been studied previously, providing new information on this population. ..
- Hypertension and alpha 2 adrenergic receptorsHaralambos Gavras; Fiscal Year: 2004....
- EXTRAMULAR RESEARCH FACILITIES CONSTRUCTIONRobert Shade; Fiscal Year: 2003..Thus, the design of the proposed laboratory facility will provide efficient space currently needed by these programs while also improving the collaborative research environment for faculty and staff. ..
- C PROTEIN AND CROSS BRIDGE FUNCTION IN HEART MUSCLESaul Winegrad; Fiscal Year: 2004..Abnormalities in its structure and function are responsible for one of the more common forms of Familial Hypertrophic Cardiomyopathy. ..
- Weight Management Skills--African American OutpatientsShiriki Kumanyika; Fiscal Year: 2005..Group 0. Secondary analyses will compare the respective treatment and control groups on diet, physical activity, and clinical CVD risk factor changes and will assess predictors of outcomes and cost-effectiveness. ..
- Equipment Support for USD Laboratory Animal ServicesDouglas Martin; Fiscal Year: 2005..The long-term goal is to achieve AAALAC accreditation. It is expected that AAALAC review for accreditation will be requested within 18 months of completion and occupancy of the new LAS. ..
- Intercellular Signaling in Obstructive NephropathyROBERT CHEVALIER; Fiscal Year: 2005..This will lead to improved outcomes in adulthood. ..
- Angiotensin, Sodium and Genes in Primate HypertensionRobert Shade; Fiscal Year: 2005..Importantly, this work will also reveal whether the genetically determined phenotype of high SLC is important in predisposing an animal to sodium-dependent hypertension. ..
- Role of MMPs in AngII induced abdominal aortic aneurysmsAlan Daugherty; Fiscal Year: 2005..The significance of this research relates to delineation of mechanism for AA formation and maturation, with emphasis on potential development of pharmacological treatments of the disease. ..
- ANGIOTENSIN AND CENTRAL NEUROHUMORAL ACTIVATION IN CHFRobert Felder; Fiscal Year: 2005..This work will provide new information concerning the role of the central nervous system in the pathophysiology of CHF and will draw attention to the possibility of CNS directed drug therapy for heart failure. ..
- Racial Differences--Stress Induced Homeostatic ResponseGregory Harshfield; Fiscal Year: 2005..abstract_text> ..
- Enhancing Subject Protections through EducationMichael Phillips; Fiscal Year: 2003..Using state-of-the-art technology, USF will share its educational programs with UCF, UCH, and community-based institutions conducting human subject research within the Tampa Bay area. ..
- UNIVERSITY OF SOUTH FLORIDA MOUSE BARRIER FACILITYM Phillips; Fiscal Year: 2004..6 to 1. The net benefit of the movable equipment requested would accrue to nationally recognized life science research directed by scientists from eight neighboring institutions that will use this new regional resource. ..
- MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASEGeorge Kaysen; Fiscal Year: 2001..We will further establish the effect of KT/V, dialyzer permeability and reuse on changes in albumin, nutritional status and acute phase response. ..